LiteFold/GO huggingface dataset:
B cell receptor complex (GO:0019815)
Namespace: cellular_component
Definition: An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
Synonyms: antibody; B cell receptor accessory molecule complex; B lymphocyte receptor complex; B-cell receptor complex; B-lymphocyte receptor complex; BCR complex; immunoglobulin complex, membrane bound
Comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
obsolete B cell receptor accessory molecule complex (GO:0019816)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: B cell receptor accessory molecule complex
Comment: This term was made obsolete because it represents a molecule and not a location or complex.
vesicle fusion with peroxisome (GO:0019817)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome.
P1 peroxisome (GO:0019819)
Namespace: cellular_component
Definition: A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms.
Synonyms: peroxisome vesicle
Comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
P2 peroxisome (GO:0019820)
Namespace: cellular_component
Definition: A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed.
Synonyms: peroxisome vesicle
Comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
P4 peroxisome (GO:0019822)
Namespace: cellular_component
Definition: A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content.
Synonyms: peroxisome vesicle
Comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
P5 peroxisome (GO:0019823)
Namespace: cellular_component
Definition: A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content.
Synonyms: peroxisome vesicle
Comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'.
P6 peroxisome (GO:0019824)
Namespace: cellular_component
Definition: A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes.
Synonyms: peroxisome vesicle
Comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'.
oxygen binding (GO:0019825)
Namespace: molecular_function
Definition: Binding to oxygen (O2).
Synonyms: cytochrome P450; cytochrome P450 activity
oxygen sensor activity (GO:0019826)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).
stem cell population maintenance (GO:0019827)
Namespace: biological_process
Definition: The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
Synonyms: maintenance of pluripotency
aspartic-type endopeptidase inhibitor activity (GO:0019828)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases.
Synonyms: aspartic protease inhibitor activity
ATPase-coupled monoatomic cation transmembrane transporter activity (GO:0019829)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
Synonyms: ATP-dependent cation transmembrane transporter activity; ATPase-coupled cation transmembrane transporter activity; cation ABC transporter; cation-transporting ATPase activity; plasma membrane cation-transporting ATPase
obsolete cadmium sensitivity/resistance (GO:0019830)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: cadmium sensitivity/resistance
Comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
obsolete mercuric sensitivity/resistance (GO:0019832)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: mercuric sensitivity/resistance
Comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
phospholipase A2 inhibitor activity (GO:0019834)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of phospholipase A2.
cytolysis (GO:0019835)
Namespace: biological_process
Definition: The rupture of cell membranes and the loss of cytoplasm.
Synonyms: autolysin activity; bacteriocin activity; bacteriolytic toxin activity; holin; lysin activity; lysis; necrosis
obsolete herbicide susceptibility/resistance (GO:0019837)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: herbicide susceptibility/resistance
Comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
growth factor binding (GO:0019838)
Namespace: molecular_function
Definition: Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
Synonyms: neurotrophin TRK receptor activity
isoprenoid binding (GO:0019840)
Namespace: molecular_function
Definition: Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
retinol binding (GO:0019841)
Namespace: molecular_function
Definition: Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.
Synonyms: vitamin A1 alcohol binding; vitamin A1 binding
vitamin binding (GO:0019842)
Namespace: molecular_function
Definition: Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
rRNA binding (GO:0019843)
Namespace: molecular_function
Definition: Binding to a ribosomal RNA.
Synonyms: base pairing with rRNA
obsolete endotoxin activity (GO:0019844)
Namespace: molecular_function
Definition: OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell.
Synonyms: endotoxin activity
Comment: This term was made obsolete because it represents a class of gene products.
obsolete exotoxin activity (GO:0019845)
Namespace: molecular_function
Definition: OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium.
Synonyms: exotoxin activity
Comment: This term was made obsolete because it represents a class of gene products.
obsolete enterotoxin activity (GO:0019846)
Namespace: molecular_function
Definition: OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms.
Synonyms: enterotoxin activity
Comment: This term was made obsolete because it represents a class of gene products.
obsolete neurotoxin activity (GO:0019847)
Namespace: molecular_function
Definition: OBSOLETE. Acts to inhibit neural function in another living organism.
Synonyms: neurotoxin activity
Comment: This term was made obsolete because it represents a class of gene products.
L-ascorbic acid metabolic process (GO:0019852)
Namespace: biological_process
Definition: The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
Synonyms: ascorbate metabolic process; ascorbate metabolism; L-ascorbic acid metabolism; vitamin C metabolic process; vitamin C metabolism
L-ascorbic acid catabolic process (GO:0019854)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
Synonyms: ascorbate catabolic process; ascorbate catabolism; L-ascorbic acid breakdown; L-ascorbic acid catabolism; L-ascorbic acid degradation; vitamin C catabolic process; vitamin C catabolism
calcium channel inhibitor activity (GO:0019855)
Namespace: molecular_function
Definition: Binds to and stops, prevents, or reduces the activity of a calcium channel.
pyrimidine nucleobase biosynthetic process (GO:0019856)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
Synonyms: pyrimidine base anabolism; pyrimidine base biosynthesis; pyrimidine base biosynthetic process; pyrimidine base formation; pyrimidine base synthesis
obsolete 5-methylcytosine metabolic process (GO:0019857)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA.
Synonyms: 5-methylcytosine metabolism
Comment: This term was obsoleted because it was redundant with DNA methylation-dependent heterochromatin formation ; GO:0006346, chromosomal 5-methylcytosine DNA demethylation pathway ; GO:0141166, or their children.
cytosine metabolic process (GO:0019858)
Namespace: biological_process
Definition: The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.
Synonyms: cytosine metabolism
thymine metabolic process (GO:0019859)
Namespace: biological_process
Definition: The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
Synonyms: thymine metabolism
uracil metabolic process (GO:0019860)
Namespace: biological_process
Definition: The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
Synonyms: uracil metabolism
IgA binding (GO:0019862)
Namespace: molecular_function
Definition: Binding to an immunoglobulin of an IgA isotype.
IgE binding (GO:0019863)
Namespace: molecular_function
Definition: Binding to an immunoglobulin of the IgE isotype.
IgG binding (GO:0019864)
Namespace: molecular_function
Definition: Binding to an immunoglobulin of an IgG isotype.
immunoglobulin binding (GO:0019865)
Namespace: molecular_function
Definition: Binding to an immunoglobulin.
organelle inner membrane (GO:0019866)
Namespace: cellular_component
Definition: The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.
Comment: See also the cellular component term 'outer membrane ; GO:0019867'.
outer membrane (GO:0019867)
Namespace: cellular_component
Definition: The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
sodium channel inhibitor activity (GO:0019871)
Namespace: molecular_function
Definition: Binds to and stops, prevents, or reduces the activity of a sodium channel.
streptomycin biosynthetic process (GO:0019872)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.
Synonyms: streptomycin anabolism; streptomycin biosynthesis; streptomycin formation; streptomycin synthesis
obsolete tellurium sensitivity/resistance (GO:0019873)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: tellurium sensitivity/resistance
Comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
6-aminohexanoate-dimer hydrolase activity (GO:0019875)
Namespace: molecular_function
Definition: Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate.
Synonyms: 6-aminohexanoic acid oligomer hydrolase activity; N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity
nylon catabolic process (GO:0019876)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids.
Synonyms: nylon breakdown; nylon catabolism; nylon degradation
obsolete L-lysine biosynthetic process via aminoadipic acid (GO:0019878)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of L-lysine by the aminoadipic pathway.
Synonyms: lysine anabolism via aminoadipic acid; lysine biosynthesis, aminoadipic acid pathway; lysine biosynthesis, aminoadipic pathway; lysine biosynthetic process, aminoadipic acid pathway; lysine biosynthetic process, aminoadipic pathway; lysine formation via aminoadipic acid; lysine synthesis via aminoadipic acid
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
obsolete peptidyl-thyronine biosynthetic process from peptidyl-tyrosine (GO:0019879)
Namespace: biological_process
Definition: OBSOLETE. The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine.
Synonyms: peptidyl-thyronine anabolism from peptidyl-tyrosine; peptidyl-thyronine formation from peptidyl-tyrosine; peptidyl-thyronine synthesis from peptidyl-tyrosine
Comment: This term was obsoleted because it represents a molecular function.
obsolete streptomycin susceptibility/resistance (GO:0019881)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: streptomycin susceptibility/resistance
Comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
antigen processing and presentation (GO:0019882)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
Synonyms: antigen presentation; antigen processing
antigen processing and presentation of endogenous antigen (GO:0019883)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.
Synonyms: antigen presentation, endogenous antigen
antigen processing and presentation of exogenous antigen (GO:0019884)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.
Synonyms: antigen presentation, exogenous antigen
antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
Synonyms: antigen presentation, endogenous peptide antigen; antigen processing, endogenous antigen via major histocompatibility complex class I; antigen processing, endogenous antigen via MHC class I; endogenous peptide antigen processing and presentation via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
Synonyms: antigen presentation, exogenous antigen via MHC class II; antigen presentation, exogenous peptide antigen; antigen processing, exogenous antigen via major histocompatibility complex class II; exogenous peptide antigen processing and presentation via MHC class II
protein kinase regulator activity (GO:0019887)
Namespace: molecular_function
Definition: Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein phosphatase regulator activity (GO:0019888)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a protein phosphatase.
Synonyms: calcineurin regulator activity; calcineurin, intrinsic regulator activity; protein phosphatase 2 regulator activity; protein phosphatase 2, intrinsic regulator activity; protein phosphatase 3 regulator activity; protein phosphatase 3, intrinsic regulator activity; protein phosphatase type 1 regulator activity; protein phosphatase type 1, intrinsic regulator activity; protein phosphatase type 2A regulator activity; protein phosphatase type 2A, intrinsic regulator activity; protein phosphatase type 2B regulator activity; protein phosphatase type 2B, intrinsic regulator activity; protein phosphatase type 4 regulator activity; protein phosphatase type 4, intrinsic regulator activity
pteridine metabolic process (GO:0019889)
Namespace: biological_process
Definition: The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.
Synonyms: pteridine metabolism
obsolete DNA replication inhibitor (GO:0019893)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: DNA replication inhibitor
Comment: This term was made obsolete because it does not represent a true molecular function.
kinesin binding (GO:0019894)
Namespace: molecular_function
Definition: Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
obsolete kinesin-associated mitochondrial adaptor activity (GO:0019895)
Namespace: molecular_function
Definition: OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria.
Comment: This term was obsoleted because it represents the function of a specific protein.
axonal transport of mitochondrion (GO:0019896)
Namespace: biological_process
Definition: The directed movement of mitochondria along microtubules in nerve cell axons.
Synonyms: axon transport of mitochondria
extrinsic component of plasma membrane (GO:0019897)
Namespace: cellular_component
Definition: The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
Synonyms: extrinsic to plasma membrane; juxtamembrane; peripheral plasma membrane protein
extrinsic component of membrane (GO:0019898)
Namespace: cellular_component
Definition: The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
Synonyms: extrinsic to membrane; peripheral membrane protein
Comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
enzyme binding (GO:0019899)
Namespace: molecular_function
Definition: Binding to an enzyme, a protein with catalytic activity.
kinase binding (GO:0019900)
Namespace: molecular_function
Definition: Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
phosphatase binding (GO:0019902)
Namespace: molecular_function
Definition: Binding to a phosphatase.
protein domain specific binding (GO:0019904)
Namespace: molecular_function
Definition: Binding to a specific domain of a protein.
Synonyms: protein domain-specific binding
syntaxin binding (GO:0019905)
Namespace: molecular_function
Definition: Binding to a syntaxin, a SNAP receptor involved in the docking of vesicles.
obsolete cyclin-dependent protein kinase activating kinase holoenzyme complex (GO:0019907)
Namespace: cellular_component
Definition: OBSOLETE. A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.