LiteFold/GO huggingface dataset:
positive regulation of neurotrophin TRK receptor signaling pathway (GO:0051388)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.
Synonyms: activation of nerve growth factor receptor signaling pathway; positive regulation of nerve growth factor receptor signaling pathway; positive regulation of nerve growth factor receptor signalling pathway; positive regulation of NGF receptor signaling pathway; positive regulation of NGF receptor signalling pathway; stimulation of nerve growth factor receptor signaling pathway; up regulation of nerve growth factor receptor signaling pathway; up-regulation of nerve growth factor receptor signaling pathway; upregulation of nerve growth factor receptor signaling pathway
obsolete inactivation of MAPKK activity (GO:0051389)
Namespace: biological_process
Definition: OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK).
Synonyms: inactivation of MAP kinase kinase activity; termination of MAP kinase kinase activity; termination of MAPKK activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete inactivation of MAPKKK activity (GO:0051390)
Namespace: biological_process
Definition: OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase kinase (MAPKKK).
Synonyms: inactivation of MAP kinase kinase kinase activity; termination of MAP kinase kinase kinase activity; termination of MAPKKK activity
Comment: This term was obsoleted because it represents a molecular function.
tRNA acetylation (GO:0051391)
Namespace: biological_process
Definition: The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.
tRNA cytidine N4-acetyltransferase activity (GO:0051392)
Namespace: molecular_function
Definition: Catalysis of the reaction: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N4-acetylcytidine in tRNA + CoA + H+ + phosphate.
Synonyms: tRNA N4-acetyltransferase activity
alpha-actinin binding (GO:0051393)
Namespace: molecular_function
Definition: Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
Synonyms: alpha-actinin 1 binding; alpha-actinin 4 binding; nonmuscle alpha-actinin binding
regulation of nerve growth factor receptor activity (GO:0051394)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.
Synonyms: regulation of NGF receptor activity
obsolete negative regulation of nerve growth factor receptor activity (GO:0051395)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.
Synonyms: down regulation of nerve growth factor receptor activity; down-regulation of nerve growth factor receptor activity; downregulation of nerve growth factor receptor activity; inhibition of nerve growth factor receptor activity; negative regulation of NGF receptor activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete positive regulation of nerve growth factor receptor activity (GO:0051396)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.
Synonyms: activation of nerve growth factor receptor activity; positive regulation of NGF receptor activity; stimulation of nerve growth factor receptor activity; up regulation of nerve growth factor receptor activity; up-regulation of nerve growth factor receptor activity; upregulation of nerve growth factor receptor activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete N-terminal basic amino acid aminopeptidase activity (GO:0051397)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain.
Synonyms: N-terminal basic amino acid aminopeptidase activity
Comment: This term was made obsolete because it represents a gene product.
obsolete N-terminal lysine aminopeptidase activity (GO:0051398)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain.
Synonyms: lysine aminopeptidase activity; lysyl aminopeptidase activity; N-terminal lysine aminopeptidase activity
Comment: This term was made obsolete because it represents a gene product.
BH domain binding (GO:0051400)
Namespace: molecular_function
Definition: Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.
Synonyms: Bcl-2 homology domain binding
neuron apoptotic process (GO:0051402)
Namespace: biological_process
Definition: Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
Synonyms: apoptosis of neuronal cells; apoptosis of neurons; neuron apoptosis; neuron programmed cell death by apoptosis; neuronal cell apoptosis; neuronal cell programmed cell death by apoptosis; programmed cell death of neuronal cells by apoptosis; programmed cell death of neurons by apoptosis; programmed cell death, neuronal cells; programmed cell death, neurons
stress-activated MAPK cascade (GO:0051403)
Namespace: biological_process
Definition: A MAPK cascade that starts with the activation of a stress-activated MAP kinase cascade.
Synonyms: MAPK11 cascade; MAPK12 cascade; MAPK13 cascade; MAPK14 cascade; SAPK cascade; stress-activated MAPK signaling pathway; stress-activated MAPK signalling pathway; stress-activated MAPKKK cascade; stress-activated MAPKKK signaling pathway; stress-activated MAPKKK signalling pathway
obsolete clostripain activity (GO:0051404)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds.
Synonyms: alpha-clostridipain; clostridiopeptidase B activity; Clostridium histolyticum proteinase B; clostripain activity
Comment: This term was made obsolete because it represents a gene product.
obsolete microbial collagenase activity (GO:0051405)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds.
Synonyms: Achromobacter iophagus collagenase; aspergillopeptidase C; azocollase activity; clostridiopeptidase A activity; clostridiopeptidase I; clostridiopeptidase II; Clostridium histolyticum collagenase activity; Clostridium histolyticum proteinase A; collagen peptidase activity; collagen protease activity; collagenase 1 activity; collagenase A activity; collagenase I activity; collagenase MMP-1; kollaza; matrix metalloproteinase-1; matrix metalloproteinase-18; matrix metalloproteinase-8; metallocollagenase activity; metalloproteinase-1; microbial collagenase activity; nucleolysin; soycollagestin
Comment: This term was made obsolete because it represents a gene product.
glycerone phosphate:phosphate antiporter activity (GO:0051407)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out).
Synonyms: dihydroxyacetone-phosphate:inorganic phosphate antiporter activity; glycerone phosphate:inorganic phosphate antiporter activity
glyceraldehyde 3-phosphate:phosphate antiporter activity (GO:0051408)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out).
Synonyms: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity
response to nitrosative stress (GO:0051409)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
detoxification of nitrogen compound (GO:0051410)
Namespace: biological_process
Definition: Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
Synonyms: detoxification of nitrogenous compound; nitric oxide (NO) detoxification
obsolete ALP binding (GO:0051411)
Namespace: molecular_function
Definition: OBSOLETE. Interacting selectively and non-covalently with ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band.
Synonyms: actinin-associated LIM protein binding; ALP binding
Comment: This term was made obsolete because it represents binding to an individual protein.
response to corticosterone (GO:0051412)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
Synonyms: response to corticosterone stimulus
response to cortisone (GO:0051413)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues.
Synonyms: response to cortisone stimulus
response to cortisol (GO:0051414)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
Synonyms: response to cortisol stimulus; response to hydrocortisone stimulus
obsolete myotilin binding (GO:0051416)
Namespace: molecular_function
Definition: OBSOLETE. Binding to myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C.
Synonyms: myotilin binding
Comment: This term was made obsolete because it represents binding to an individual protein.
microtubule nucleation by spindle pole body (GO:0051417)
Namespace: biological_process
Definition: The 'de novo' formation of a microtubule, mediated by the spindle pole body.
Synonyms: microtubule nucleation by SPB; SPB-mediated microtubule nucleation; spindle pole body-mediated microtubule nucleation
microtubule nucleation by microtubule organizing center (GO:0051418)
Namespace: biological_process
Definition: The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.
Synonyms: microtubule nucleation by microtubule organising centre; microtubule nucleation by MTOC; microtubule organizing center-mediated microtubule nucleation; MTOC-mediated microtubule nucleation
obsolete nebulin binding (GO:0051419)
Namespace: molecular_function
Definition: OBSOLETE. Binding to nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone.
Synonyms: nebulin binding
Comment: This term was made obsolete because it represents binding to an individual protein.
obsolete nebulette binding (GO:0051420)
Namespace: molecular_function
Definition: OBSOLETE. Binding to nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin.
Synonyms: nebulette binding
Comment: This term was made obsolete because it represents binding to an individual protein.
obsolete regulation of endo-1,4-beta-xylanase activity (GO:0051421)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
Synonyms: endo-1,4-beta-xylanase regulator; xylanase regulator
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of endo-1,4-beta-xylanase activity (GO:0051422)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops or reduces the rate of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
Synonyms: down regulation of endo-1,4-beta-xylanase activity; down-regulation of endo-1,4-beta-xylanase activity; downregulation of endo-1,4-beta-xylanase activity; endo-1,4-beta-xylanase inhibitor; inhibition of endo-1,4-beta-xylanase activity; xylanase inhibitor
Comment: This term was obsoleted because it represents a molecular function.
obsolete positive regulation of endo-1,4-beta-xylanase activity (GO:0051423)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
Synonyms: activation of endo-1,4-beta-xylanase activity; endo-1,4-beta-xylanase activator; stimulation of endo-1,4-beta-xylanase activity; up regulation of endo-1,4-beta-xylanase activity; up-regulation of endo-1,4-beta-xylanase activity; upregulation of endo-1,4-beta-xylanase activity; xylanase activator
Comment: This term was obsoleted because it represents a molecular function.
corticotropin-releasing hormone binding (GO:0051424)
Namespace: molecular_function
Definition: Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.
Synonyms: corticoliberin binding; corticotropin-releasing factor binding; CRF binding; CRH binding
PTB domain binding (GO:0051425)
Namespace: molecular_function
Definition: Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain.
Synonyms: phosphotyrosine-interacting domain binding; PID binding
hormone receptor binding (GO:0051427)
Namespace: molecular_function
Definition: Binding to a receptor for a hormone.
peptide hormone receptor binding (GO:0051428)
Namespace: molecular_function
Definition: Binding to a receptor for a peptide hormone.
Synonyms: polypeptide hormone receptor binding
corticotropin-releasing hormone receptor binding (GO:0051429)
Namespace: molecular_function
Definition: Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.
Synonyms: corticotropin releasing factor receptor binding; corticotropin releasing factor receptor ligand; corticotropin-releasing factor receptor binding; CRF receptor binding; CRH receptor binding; CRHR binding
corticotropin-releasing hormone receptor 1 binding (GO:0051430)
Namespace: molecular_function
Definition: Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
Synonyms: CRHR1 binding; type 1 corticotropin releasing factor receptor binding; type 1 corticotropin releasing factor receptor ligand; type 1 corticotropin-releasing factor receptor binding
corticotropin-releasing hormone receptor 2 binding (GO:0051431)
Namespace: molecular_function
Definition: Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery.
Synonyms: CRHR2 binding; type 2 corticotropin releasing factor receptor binding; type 2 corticotropin releasing factor receptor ligand; type 2 corticotropin-releasing factor receptor binding
BH1 domain binding (GO:0051432)
Namespace: molecular_function
Definition: Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.
BH2 domain binding (GO:0051433)
Namespace: molecular_function
Definition: Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.
BH3 domain binding (GO:0051434)
Namespace: molecular_function
Definition: Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.
BH4 domain binding (GO:0051435)
Namespace: molecular_function
Definition: Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.
obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle.
Synonyms: anaphase promoting complex inhibition during mitotic cell cycle; anaphase-promoting complex inhibition during mitotic cell cycle; APC inhibition during mitotic cell cycle; down regulation of ubiquitin ligase activity during mitotic cell cycle; down-regulation of ubiquitin ligase activity during mitotic cell cycle; downregulation of ubiquitin ligase activity during mitotic cell cycle; inhibition of ubiquitin ligase activity during mitotic cell cycle; mitotic anaphase promoting complex inhibition; mitotic anaphase promoting complex inhibitor; mitotic anaphase-promoting complex inhibition; mitotic anaphase-promoting complex inhibitor; mitotic APC inhibition; mitotic APC inhibitor; mitotic SCF complex inhibitor; mitotic ubiquitin ligase inhibitor; negative regulation of ubiquitin ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Comment: This term was obsoleted because it should be captured as a GO-CAM model.
obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition (GO:0051437)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition.
Synonyms: activation of ubiquitin ligase activity during mitotic cell cycle; mitotic SCF complex activator; mitotic ubiquitin ligase activator; positive regulation of ubiquitin ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; stimulation of ubiquitin ligase activity during mitotic cell cycle; up regulation of ubiquitin ligase activity during mitotic cell cycle; up-regulation of ubiquitin ligase activity during mitotic cell cycle; upregulation of ubiquitin ligase activity during mitotic cell cycle
Comment: This term was obsoleted because it should be captured as a GO-CAM model.
regulation of ubiquitin-protein transferase activity (GO:0051438)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of ubiquitin transferase activity.
Synonyms: anaphase-promoting complex regulator; APC regulator; regulation of ubiquitin transferase activity; SCF complex regulator; ubiquitin transferase regulator; ubiquitin-protein transferase regulator
obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)
Namespace: biological_process
Definition: OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle.
Synonyms: mitotic anaphase-promoting complex regulator; mitotic APC regulator; mitotic SCF complex regulator; mitotic ubiquitin ligase regulator; mitotic ubiquitin-protein ligase regulator; regulation of ubiquitin ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Comment: false
obsolete regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle (GO:0051440)
Namespace: biological_process
Definition: OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle.
Synonyms: meiotic anaphase-promoting complex regulator; meiotic APC regulator; meiotic SCF complex regulator; meiotic ubiquitin ligase regulator; meiotic ubiquitin-protein ligase regulator; regulation of ubiquitin ligase activity during meiotic cell cycle; regulation of ubiquitin-protein ligase activity during meiotic cell cycle
Comment: This term was obsoleted because it should be captured as a GO-CAM model.