LiteFold/GO huggingface dataset:
mitotic G1 DNA damage checkpoint signaling (GO:0031571)
Namespace: biological_process
Definition: A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.
Synonyms: G1 DNA damage checkpoint; G1/S DNA damage checkpoint; intracellular signal transduction involved in G1 DNA damage checkpoint; intracellular signal transduction involved in G1/S DNA damage checkpoint; intracellular signal transduction pathway involved in G1 DNA damage checkpoint; intracellular signal transduction pathway involved in G1/S DNA damage checkpoint; intracellular signaling cascade involved in G1 DNA damage checkpoint; intracellular signaling cascade involved in G1/S DNA damage checkpoint; intracellular signaling chain involved in G1 DNA damage checkpoint; intracellular signaling chain involved in G1/S DNA damage checkpoint; intracellular signaling pathway involved in G1 DNA damage checkpoint; intracellular signaling pathway involved in G1/S DNA damage checkpoint; mitotic cell cycle G1/S transition DNA damage checkpoint; mitotic G1 DNA damage checkpoint; signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint; signal transduction involved in mitotic G1 DNA damage checkpoint; signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint; signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint; signal transmission via intracellular cascade involved in G1 DNA damage checkpoint
mitotic intra-S DNA damage checkpoint signaling (GO:0031573)
Namespace: biological_process
Definition: A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
Synonyms: intra-S DNA damage checkpoint; mitotic intra-S DNA damage checkpoint; S-phase checkpoint; signal transduction involved in intra-S DNA damage checkpoint
spindle checkpoint signaling (GO:0031577)
Namespace: biological_process
Definition: A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.
Synonyms: signal transduction involved in spindle checkpoint; spindle checkpoint
Comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term.
mitotic spindle orientation checkpoint signaling (GO:0031578)
Namespace: biological_process
Definition: A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.
Synonyms: mitotic cell cycle spindle orientation checkpoint; mitotic spindle orientation checkpoint; signal transduction involved in mitotic cell cycle spindle orientation checkpoint; SOC; spindle position checkpoint; SPOC
membrane raft organization (GO:0031579)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.
Synonyms: lipid raft organization; membrane raft organisation; membrane raft organization and biogenesis
membrane raft distribution (GO:0031580)
Namespace: biological_process
Definition: The process that establishes the spatial arrangement of membrane rafts within a cellular membrane.
Synonyms: lipid raft distribution
hemidesmosome assembly (GO:0031581)
Namespace: biological_process
Definition: Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.
replication fork arrest at rDNA repeats (GO:0031582)
Namespace: biological_process
Definition: A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer.
Synonyms: replication fork arrest at ribosomal DNA repeats; replication fork blocking at rDNA repeats
phospholipase D-activating G protein-coupled receptor signaling pathway (GO:0031583)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase D (PLD) and a subsequent increase in the intracellular concentration of phosphatidic acid (PA).
Synonyms: activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway; G-protein signalling, phospholipase D activating pathway; phospholipase D-activating G-protein coupled receptor signaling pathway
Comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation.
obsolete activation of phospholipase D activity (GO:0031584)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of inactive phospholipase D.
Comment: This term was obsoleted because it represents a molecular function. Consider molecular function regulator activity ; GO:0098772 or a child.
obsolete regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity (GO:0031585)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms: regulation of inositol-1,4,5-triphosphate receptor activity; regulation of IP3 receptor activity
Comment: This term was obsoleted because it represents a molecular function. Consider molecular function regulator activity ; GO:0098772 or a child.
obsolete positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity (GO:0031587)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.
Synonyms: activation of IP3 receptor activity; positive regulation of inositol-1,4,5-trisphosphate receptor activity; positive regulation of IP3 receptor activity; stimulation of IP3 receptor activity; up regulation of IP3 receptor activity; up-regulation of IP3 receptor activity; upregulation of IP3 receptor activity
Comment: This term was obsoleted because it represents a molecular function.
nucleotide-activated protein kinase complex (GO:0031588)
Namespace: cellular_component
Definition: A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
Synonyms: 5'-AMP-activated protein kinase complex; ADP-activated protein kinase complex; AMP-activated protein kinase complex; AMPK complex; Snf1 kinase complex; Snf1 serine/threonine protein kinase complex; SNF1/AMPK protein kinase complex
cell-substrate adhesion (GO:0031589)
Namespace: biological_process
Definition: The attachment of a cell to the underlying substrate via adhesion molecules.
wybutosine biosynthetic process (GO:0031591)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.
Synonyms: yW biosynthesis; yW biosynthetic process
Comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
centrosomal corona (GO:0031592)
Namespace: cellular_component
Definition: An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin.
Comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material.
polyubiquitin modification-dependent protein binding (GO:0031593)
Namespace: molecular_function
Definition: Binding to a protein upon poly-ubiquitination of the target protein.
neuromuscular junction (GO:0031594)
Namespace: cellular_component
Definition: The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
Synonyms: motor endplate; NMJ
Comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
nuclear proteasome complex (GO:0031595)
Namespace: cellular_component
Definition: A proteasome found in the nucleus of a cell.
obsolete ER proteasome complex (GO:0031596)
Namespace: cellular_component
Definition: OBSOLETE. A proteasome found in the endoplasmic reticulum of a cell.
Comment: This term was made obsolete because there is no evidence in the literature of its existence.
nuclear proteasome regulatory particle (GO:0031598)
Namespace: cellular_component
Definition: The regulatory subcomplex of a proteasome located in the nucleus of a cell.
obsolete ER proteasome regulatory particle (GO:0031599)
Namespace: cellular_component
Definition: OBSOLETE. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell.
Comment: This term was made obsolete because there is no evidence in the literature of its existence.
cytosolic proteasome regulatory particle (GO:0031600)
Namespace: cellular_component
Definition: A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex.
nuclear proteasome core complex (GO:0031601)
Namespace: cellular_component
Definition: The core complex of a proteasome located in the nucleus of a cell.
obsolete ER proteasome core complex (GO:0031602)
Namespace: cellular_component
Definition: OBSOLETE. The core complex of a proteasome located in the endoplasmic reticulum of a cell.
Comment: This term was made obsolete because there is no evidence in the literature of its existence.
cytosolic proteasome core complex (GO:0031603)
Namespace: cellular_component
Definition: The core complex of a proteasome located in the cytosol of a cell.
nuclear proteasome core complex, alpha-subunit complex (GO:0031604)
Namespace: cellular_component
Definition: The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell.
obsolete ER proteasome core complex, alpha-subunit complex (GO:0031605)
Namespace: cellular_component
Definition: OBSOLETE. The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell.
Comment: This term was made obsolete because there is no evidence in the literature of its existence.
cytosolic proteasome core complex, alpha-subunit complex (GO:0031606)
Namespace: cellular_component
Definition: The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex.
obsolete ER proteasome core complex, beta-subunit complex (GO:0031608)
Namespace: cellular_component
Definition: OBSOLETE. The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell.
Comment: This term was made obsolete because there is no evidence in the literature of its existence.
cytosolic proteasome core complex, beta-subunit complex (GO:0031609)
Namespace: cellular_component
Definition: The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex.
nuclear proteasome regulatory particle, base subcomplex (GO:0031610)
Namespace: cellular_component
Definition: The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell.
obsolete ER proteasome regulatory particle, base subcomplex (GO:0031611)
Namespace: cellular_component
Definition: OBSOLETE. The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell.
Comment: This term was made obsolete because there is no evidence in the literature of its existence.
cytosolic proteasome regulatory particle, base subcomplex (GO:0031612)
Namespace: cellular_component
Definition: The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell.
nuclear proteasome regulatory particle, lid subcomplex (GO:0031613)
Namespace: cellular_component
Definition: The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell.
obsolete ER proteasome regulatory particle, lid subcomplex (GO:0031614)
Namespace: cellular_component
Definition: OBSOLETE. The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell.
Comment: This term was made obsolete because there is no evidence in the literature of its existence.
cytosolic proteasome regulatory particle, lid subcomplex (GO:0031615)
Namespace: cellular_component
Definition: The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.
spindle pole centrosome (GO:0031616)
Namespace: cellular_component
Definition: A centrosome from which one pole of a mitotic or meiotic spindle is organized.
homologous chromosome orientation in meiotic metaphase I (GO:0031619)
Namespace: biological_process
Definition: The cell cycle process in which the sister centromeres and kinetochores of one chromosome are fused and orientated so the chromosomes attach to microtubules that emanate from the same spindle pole. This process ensures that homologous l chromosomes are segregated at anaphase of meiosis I.
Synonyms: homologous chromosome orientation during meiosis; homologous chromosome orientation during meiosis I
regulation of fever generation (GO:0031620)
Namespace: biological_process
Definition: Any process that modulates the rate or extent of fever generation.
Synonyms: regulation of pyrexia
negative regulation of fever generation (GO:0031621)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate or extent of fever generation.
Synonyms: down regulation of fever; down-regulation of fever; downregulation of fever; inhibition of fever; negative regulation of pyrexia
positive regulation of fever generation (GO:0031622)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, or extent of fever generation.
Synonyms: activation of fever; positive regulation of pyrexia; stimulation of fever; up regulation of fever; up-regulation of fever; upregulation of fever
receptor internalization (GO:0031623)
Namespace: biological_process
Definition: A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
ubiquitin conjugating enzyme binding (GO:0031624)
Namespace: molecular_function
Definition: Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.
ubiquitin protein ligase binding (GO:0031625)
Namespace: molecular_function
Definition: Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
Synonyms: ubiquitin ligase binding
beta-endorphin binding (GO:0031626)
Namespace: molecular_function
Definition: Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin.
telomeric loop formation (GO:0031627)
Namespace: biological_process
Definition: The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region.
Synonyms: T loop biosynthesis; T loop formation; t-loop biosynthesis; t-loop formation
synaptic vesicle fusion to presynaptic active zone membrane (GO:0031629)
Namespace: biological_process
Definition: Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
Synonyms: synaptic vesicle fusion; synaptic vesicle fusion to pre-synaptic membrane; synaptic vesicle fusion to presynaptic membrane
regulation of synaptic vesicle fusion to presynaptic active zone membrane (GO:0031630)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
Synonyms: regulation of synaptic vesicle fusion to pre-synaptic membrane; regulation of synaptic vesicle fusion to presynaptic membrane
negative regulation of synaptic vesicle fusion to presynaptic active zone membrane (GO:0031631)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
Synonyms: down regulation of synaptic vesicle fusion to presynaptic active zone membrane; down regulation of synaptic vesicle fusion to presynaptic membrane; down-regulation of synaptic vesicle fusion to presynaptic active zone membrane; down-regulation of synaptic vesicle fusion to presynaptic membrane; downregulation of synaptic vesicle fusion to presynaptic active zone membrane; downregulation of synaptic vesicle fusion to presynaptic membrane; inhibition of synaptic vesicle fusion to presynaptic membrane; negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane; negative regulation of synaptic vesicle fusion to pre-synaptic membrane; negative regulation of synaptic vesicle fusion to presynaptic membrane
positive regulation of synaptic vesicle fusion to presynaptic active zone membrane (GO:0031632)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
Synonyms: activation of synaptic vesicle fusion to presynaptic membrane; negative regulation of synaptic vesicle fusion to presynaptic membrane; positive regulation of synaptic vesicle fusion to pre-synaptic membrane; stimulation of synaptic vesicle fusion to presynaptic membrane; up regulation of synaptic vesicle fusion to presynaptic active zone membrane; up regulation of synaptic vesicle fusion to presynaptic membrane; up-regulation of synaptic vesicle fusion to presynaptic active zone membrane; up-regulation of synaptic vesicle fusion to presynaptic membrane; upregulation of synaptic vesicle fusion to presynaptic membrane
xanthophore (GO:0031633)
Namespace: cellular_component
Definition: A chromatophore containing yellow pigment.
Comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells.
replication fork barrier binding (GO:0031634)
Namespace: molecular_function
Definition: Binding to replication fork barriers, sites that inhibit the progress of replication forks.
adenylate cyclase-inhibiting opioid receptor signaling pathway (GO:0031635)
Namespace: biological_process
Definition: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: inhibition of adenylate cyclase activity by opioid receptor signaling pathway; inhibition of adenylate cyclase activity by opioid receptor signalling pathway; opioid receptor, adenylate cyclase inhibiting pathway
regulation of neuronal synaptic plasticity in response to neurotrophin (GO:0031637)
Namespace: biological_process
Definition: The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
Synonyms: neurotrophin-induced neuronal synaptic plasticity
zymogen activation (GO:0031638)
Namespace: biological_process
Definition: The proteolytic processing of an inactive enzyme to an active form.
Synonyms: zymogen activation by proteolytic cleavage
plasminogen activation (GO:0031639)
Namespace: biological_process
Definition: The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
Synonyms: cleavage of plasminogen to plasmin
killing of cells of another organism (GO:0031640)
Namespace: biological_process
Definition: Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
Synonyms: killing of cells of other organism
regulation of myelination (GO:0031641)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
negative regulation of myelination (GO:0031642)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
Synonyms: down regulation of myelination; down-regulation of myelination; downregulation of myelination; inhibition of myelination
positive regulation of myelination (GO:0031643)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
Synonyms: activation of myelination; stimulation of myelination; up regulation of myelination; up-regulation of myelination; upregulation of myelination
regulation of nervous system process (GO:0031644)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
Synonyms: regulation of neurological process; regulation of neurological system process; regulation of neurophysiological process
negative regulation of nervous system process (GO:0031645)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.
Synonyms: down regulation of neurological process; down-regulation of neurological process; downregulation of neurological process; inhibition of neurological process; negative regulation of neurological process; negative regulation of neurological system process; negative regulation of neurophysiological process