LiteFold/GO huggingface dataset:
glucan endo-1,3-beta-D-glucosidase activity (GO:0042973)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.
Synonyms: (1->3)-beta-glucan 3-glucanohydrolase activity; (1->3)-beta-glucan endohydrolase activity; 1,3-beta-D-glucan 3-glucanohydrolase activity; 1,3-beta-D-glucan glucanohydrolase activity; beta-1,3-glucanase; callase activity; endo-(1,3)-beta-D-glucanase activity; endo-(1->3)-beta-D-glucanase activity; endo-1,3-beta-D-glucanase; endo-1,3-beta-glucanase activity; endo-1,3-beta-glucosidase activity; kitalase activity; laminaranase activity; laminarinase activity; oligo-1,3-glucosidase activity
nuclear retinoic acid receptor binding (GO:0042974)
Namespace: molecular_function
Definition: Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
Synonyms: RAR binding; retinoic acid receptor binding
peroxisome proliferator activated receptor binding (GO:0042975)
Namespace: molecular_function
Definition: Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma.
Synonyms: PPAR binding
activation of Janus kinase activity (GO:0042976)
Namespace: biological_process
Definition: The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
Synonyms: activation of JAK protein; activation of JAK protein by tyrosine phosphorylation; activation of JAK1 kinase activity; activation of JAK1 protein; activation of JAK2 kinase activity; activation of JAK2 protein; positive regulation of JAK protein activity by tyrosine phosphorylation; tyrosine phosphorylation of JAK protein; tyrosine phosphorylation of JAK1 protein; tyrosine phosphorylation of JAK2 protein
ornithine decarboxylase activator activity (GO:0042978)
Namespace: molecular_function
Definition: Binds to and increases ornithine decarboxylase activity.
Synonyms: L-ornithine carboxy-lyase activator activity
obsolete cystic fibrosis transmembrane conductance regulator binding (GO:0042980)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein.
Synonyms: CFTR binding; cystic fibrosis transmembrane conductance regulator binding
Comment: This term was made obsolete because it represents binding to an individual protein.
regulation of apoptotic process (GO:0042981)
Namespace: biological_process
Definition: Any process that modulates the occurrence or rate of cell death by apoptotic process.
Synonyms: apoptosis regulator activity; regulation of apoptosis
Comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
amyloid precursor protein metabolic process (GO:0042982)
Namespace: biological_process
Definition: The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms: amyloid precursor protein metabolism; APP metabolic process; APP metabolism
amyloid precursor protein biosynthetic process (GO:0042983)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms: amyloid precursor protein anabolism; amyloid precursor protein biosynthesis; amyloid precursor protein formation; amyloid precursor protein synthesis; APP biosynthesis; APP biosynthetic process
regulation of amyloid precursor protein biosynthetic process (GO:0042984)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
Synonyms: regulation of amyloid precursor protein anabolism; regulation of amyloid precursor protein biosynthesis; regulation of amyloid precursor protein formation; regulation of amyloid precursor protein synthesis; regulation of APP biosynthesis; regulation of APP biosynthetic process
negative regulation of amyloid precursor protein biosynthetic process (GO:0042985)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
Synonyms: down regulation of amyloid precursor protein biosynthetic process; down-regulation of amyloid precursor protein biosynthetic process; downregulation of amyloid precursor protein biosynthetic process; inhibition of amyloid precursor protein biosynthetic process; negative regulation of amyloid precursor protein anabolism; negative regulation of amyloid precursor protein biosynthesis; negative regulation of amyloid precursor protein formation; negative regulation of amyloid precursor protein synthesis; negative regulation of APP biosynthesis; negative regulation of APP biosynthetic process
positive regulation of amyloid precursor protein biosynthetic process (GO:0042986)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
Synonyms: activation of amyloid precursor protein biosynthetic process; positive regulation of amyloid precursor protein anabolism; positive regulation of amyloid precursor protein biosynthesis; positive regulation of amyloid precursor protein formation; positive regulation of amyloid precursor protein synthesis; positive regulation of APP biosynthesis; positive regulation of APP biosynthetic process; stimulation of amyloid precursor protein biosynthetic process; up regulation of amyloid precursor protein biosynthetic process; up-regulation of amyloid precursor protein biosynthetic process; upregulation of amyloid precursor protein biosynthetic process
X11-like protein binding (GO:0042988)
Namespace: molecular_function
Definition: Binding to X11-like protein, a neuron-specific adaptor protein.
Synonyms: X11L binding
obsolete transcription factor import into nucleus (GO:0042991)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a transcription factor from the cytoplasm to the nucleus.
Synonyms: transcription factor import into cell nucleus; transcription factor transport from cytoplasm to nucleus; transcription factor-nucleus import
Comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
obsolete negative regulation of transcription factor import into nucleus (GO:0042992)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
Synonyms: down regulation of transcription factor import into nucleus; down-regulation of transcription factor import into nucleus; downregulation of transcription factor import into nucleus; inhibition of transcription factor import into nucleus; negative regulation of transcription factor import into cell nucleus; negative regulation of transcription factor transport from cytoplasm to nucleus; negative regulation of transcription factor-nucleus import
Comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
obsolete positive regulation of transcription factor import into nucleus (GO:0042993)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
Synonyms: activation of transcription factor import into nucleus; positive regulation of transcription factor import into cell nucleus; positive regulation of transcription factor transport from cytoplasm to nucleus; positive regulation of transcription factor-nucleus import; stimulation of transcription factor import into nucleus; up regulation of transcription factor import into nucleus; up-regulation of transcription factor import into nucleus; upregulation of transcription factor import into nucleus
Comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
obsolete cytoplasmic sequestering of transcription factor (GO:0042994)
Namespace: biological_process
Definition: OBSOLETE. The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
Synonyms: cytoplasmic retention of transcription factor; cytoplasmic sequestration of transcription factor; cytoplasmic storage of transcription factor; maintenance of transcription factor protein location in cytoplasm; retention of transcription factor in cytoplasm; sequestering of transcription factor in cytoplasm; sequestration of transcription factor in cytoplasm; storage of transcription factor in cytoplasm; transcription factor binding, cytoplasmic sequestering
Comment: The reason for obsoletion is that this term represents a molecular function, not biological process.
cell projection (GO:0042995)
Namespace: cellular_component
Definition: A prolongation or process extending from a cell, e.g. a flagellum or axon.
Synonyms: cell process; cellular process; cellular projection
regulation of Golgi to plasma membrane protein transport (GO:0042996)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
negative regulation of Golgi to plasma membrane protein transport (GO:0042997)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
Synonyms: down regulation of Golgi to plasma membrane protein transport; down-regulation of Golgi to plasma membrane protein transport; downregulation of Golgi to plasma membrane protein transport; inhibition of Golgi to plasma membrane protein transport
positive regulation of Golgi to plasma membrane protein transport (GO:0042998)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
Synonyms: activation of Golgi to plasma membrane protein transport; stimulation of Golgi to plasma membrane protein transport; up regulation of Golgi to plasma membrane protein transport; up-regulation of Golgi to plasma membrane protein transport; upregulation of Golgi to plasma membrane protein transport
obsolete regulation of Golgi to plasma membrane CFTR protein transport (GO:0042999)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.
Comment: This term was made obsolete because it involved a specific gene product.
obsolete Golgi to plasma membrane CFTR protein transport (GO:0043000)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.
Synonyms: Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport
Comment: This term was made obsolete because it involved a specific gene product.
Golgi to plasma membrane protein transport (GO:0043001)
Namespace: biological_process
Definition: The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. Golgi to plasma membrane transport precedes exocytosis.
obsolete negative regulation of Golgi to plasma membrane CFTR protein transport (GO:0043002)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.
Synonyms: down regulation of Golgi to plasma membrane CFTR protein transport; down-regulation of Golgi to plasma membrane CFTR protein transport; downregulation of Golgi to plasma membrane CFTR protein transport; inhibition of Golgi to plasma membrane CFTR protein transport
Comment: This term was made obsolete because it involved a specific gene product.
obsolete positive regulation of Golgi to plasma membrane CFTR protein transport (GO:0043003)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.
Synonyms: activation of Golgi to plasma membrane CFTR protein transport; stimulation of Golgi to plasma membrane CFTR protein transport; up regulation of Golgi to plasma membrane CFTR protein transport; up-regulation of Golgi to plasma membrane CFTR protein transport; upregulation of Golgi to plasma membrane CFTR protein transport
Comment: This term was made obsolete because it involved a specific gene product.
obsolete cytoplasmic sequestering of CFTR protein (GO:0043004)
Namespace: biological_process
Definition: OBSOLETE. The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane.
Synonyms: cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein; cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein; cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein); cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein; maintenance of CFTR protein location in cytoplasm; retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm; sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm; sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm; storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm
Comment: This term was made obsolete because it involved a specific gene product.
neuron projection (GO:0043005)
Namespace: cellular_component
Definition: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
Synonyms: nerve fiber; neurite; neuron process; neuron protrusion; neuronal cell projection
obsolete activation of phospholipase A2 activity by calcium-mediated signaling (GO:0043006)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal.
Synonyms: activation of phospholipase A2 activity by calcium-mediated signalling; calcium-dependent activation of phospholipase A2; calcium-dependent phospholipase A2 activation
Comment: This term was obsoleted because it represents a molecular function.
maintenance of rDNA (GO:0043007)
Namespace: biological_process
Definition: Any process involved in sustaining the fidelity and copy number of rDNA repeats.
Synonyms: rDNA maintenance; ribosomal DNA maintenance
ATP-dependent protein binding (GO:0043008)
Namespace: molecular_function
Definition: Binding to a protein or protein complex using energy from ATP hydrolysis.
chordate embryonic development (GO:0043009)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
camera-type eye development (GO:0043010)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
myeloid dendritic cell differentiation (GO:0043011)
Namespace: biological_process
Definition: The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
regulation of fusion of sperm to egg plasma membrane (GO:0043012)
Namespace: biological_process
Definition: Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane.
Synonyms: regulation of sperm-oocyte fusion
negative regulation of fusion of sperm to egg plasma membrane (GO:0043013)
Namespace: biological_process
Definition: Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane.
Synonyms: down regulation of fusion of sperm to egg plasma membrane; down-regulation of fusion of sperm to egg plasma membrane; downregulation of fusion of sperm to egg plasma membrane; inhibition of fusion of sperm to egg plasma membrane; inhibition of sperm-oocyte fusion; negative regulation of sperm-oocyte fusion
alpha-tubulin binding (GO:0043014)
Namespace: molecular_function
Definition: Binding to the microtubule constituent protein alpha-tubulin.
Synonyms: alpha tubulin binding
gamma-tubulin binding (GO:0043015)
Namespace: molecular_function
Definition: Binding to the microtubule constituent protein gamma-tubulin.
Synonyms: gamma tubulin binding
NADPH oxidase complex (GO:0043020)
Namespace: cellular_component
Definition: A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.
Synonyms: flavocytochrome b558; respiratory-burst oxidase
ribonucleoprotein complex binding (GO:0043021)
Namespace: molecular_function
Definition: Binding to a complex of RNA and protein.
Synonyms: protein-RNA complex binding; ribonucleoprotein binding; RNP binding
ribosome binding (GO:0043022)
Namespace: molecular_function
Definition: Binding to a ribosome.
Synonyms: ribosome receptor activity
ribosomal large subunit binding (GO:0043023)
Namespace: molecular_function
Definition: Binding to a large ribosomal subunit.
ribosomal small subunit binding (GO:0043024)
Namespace: molecular_function
Definition: Binding to a small ribosomal subunit.
neuronal cell body (GO:0043025)
Namespace: cellular_component
Definition: The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
Synonyms: neuron cell body; neuronal cell soma
Comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
cysteine-type endopeptidase inhibitor activity involved in apoptotic process (GO:0043027)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
Synonyms: caspase inhibitor activity
cysteine-type endopeptidase regulator activity involved in apoptotic process (GO:0043028)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.
Synonyms: caspase regulator activity
T cell homeostasis (GO:0043029)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Synonyms: T lymphocyte homeostasis; T-cell homeostasis; T-lymphocyte homeostasis
Comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.
regulation of macrophage activation (GO:0043030)
Namespace: biological_process
Definition: Any process that modulates the frequency or rate of macrophage activation.
Synonyms: regulation of macrophage polarization
negative regulation of macrophage activation (GO:0043031)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.
Synonyms: down regulation of macrophage activation; down-regulation of macrophage activation; downregulation of macrophage activation; inhibition of macrophage activation; negative regulation of macrophage polarization
positive regulation of macrophage activation (GO:0043032)
Namespace: biological_process
Definition: Any process that stimulates, induces or increases the rate of macrophage activation.
Synonyms: activation of macrophage activation; positive regulation of macrophage polarization; stimulation of macrophage activation; up regulation of macrophage activation; up-regulation of macrophage activation; upregulation of macrophage activation
isoamylase complex (GO:0043033)
Namespace: cellular_component
Definition: A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages.
Synonyms: debranching enzyme complex
amino acid activation (GO:0043038)
Namespace: biological_process
Definition: The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.
tRNA aminoacylation (GO:0043039)
Namespace: biological_process
Definition: The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.
Synonyms: amino acid activation; aminoacyl-tRNA biosynthesis; aminoacyl-tRNA biosynthetic process; tRNA charging
tRNA aminoacylation for nonribosomal peptide biosynthetic process (GO:0043040)
Namespace: biological_process
Definition: The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis.
Synonyms: tRNA aminoacylation for nonribosomal peptide anabolism; tRNA aminoacylation for nonribosomal peptide biosynthesis; tRNA aminoacylation for nonribosomal peptide formation; tRNA aminoacylation for nonribosomal peptide synthesis
amino acid activation for nonribosomal peptide biosynthetic process (GO:0043041)
Namespace: biological_process
Definition: Activation of an amino acid for incorporation into a peptide by a nonribosomal process.
Synonyms: nonribosomal amino acid activation
amino acid adenylylation by nonribosomal peptide synthase (GO:0043042)
Namespace: biological_process
Definition: Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor.
Synonyms: amino acid adenylation by nonribosomal peptide synthase; amino acid adenylation by NRPS