LiteFold/GO huggingface dataset:
activin A complex (GO:0043509)
Namespace: cellular_component
Definition: A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).
Comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'.
activin B complex (GO:0043510)
Namespace: cellular_component
Definition: A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B).
Comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
inhibin complex (GO:0043511)
Namespace: cellular_component
Definition: Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B.
Comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
inhibin A complex (GO:0043512)
Namespace: cellular_component
Definition: Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit.
Comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
inhibin B complex (GO:0043513)
Namespace: cellular_component
Definition: Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit.
Comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
interleukin-12 complex (GO:0043514)
Namespace: cellular_component
Definition: A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
Synonyms: IL-12 complex; IL12A; IL12B; p35; p40
Comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
kinetochore binding (GO:0043515)
Namespace: molecular_function
Definition: Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.
regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms: regulation of p53 induced by DNA damage response
positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)
Namespace: biological_process
Definition: Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms: activation of DNA damage response, signal transduction by p53 class mediator; positive regulation of p53 induced by DNA damage response; stimulation of DNA damage response, signal transduction by p53 class mediator; up regulation of DNA damage response, signal transduction by p53 class mediator; up-regulation of DNA damage response, signal transduction by p53 class mediator; upregulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms: down regulation of DNA damage response, signal transduction by p53 class mediator; down-regulation of DNA damage response, signal transduction by p53 class mediator; downregulation of DNA damage response, signal transduction by p53 class mediator; inhibition of DNA damage response, signal transduction by p53 class mediator; negative regulation of p53 induced by DNA damage response
regulation of myosin II filament organization (GO:0043519)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.
Synonyms: regulation of myosin II filament assembly or disassembly; regulation of myosin II filament organisation
regulation of myosin II filament assembly (GO:0043520)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules.
regulation of myosin II filament disassembly (GO:0043521)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules.
leucine zipper domain binding (GO:0043522)
Namespace: molecular_function
Definition: Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
Synonyms: leucine zipper binding
regulation of neuron apoptotic process (GO:0043523)
Namespace: biological_process
Definition: Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
Synonyms: regulation of apoptosis of neuronal cells; regulation of apoptosis of neurons; regulation of neuron apoptosis; regulation of neuron programmed cell death; regulation of neuronal cell programmed cell death; regulation of programmed cell death of neuronal cells; regulation of programmed cell death, neurons
negative regulation of neuron apoptotic process (GO:0043524)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
Synonyms: down regulation of neuron apoptosis; down-regulation of neuron apoptosis; downregulation of neuron apoptosis; inhibition of neuron apoptosis; negative regulation of neuron apoptosis; negative regulation of programmed cell death, neurons; neuron survival
positive regulation of neuron apoptotic process (GO:0043525)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
Synonyms: activation of neuron apoptosis; positive regulation of neuron apoptosis; positive regulation of programmed cell death, neurons; stimulation of neuron apoptosis; up regulation of neuron apoptosis; up-regulation of neuron apoptosis; upregulation of neuron apoptosis
obsolete neuroprotection (GO:0043526)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss.
Synonyms: neuroprotection
Comment: This term was made obsolete because it refers to assays rather than processes. If neuron death by apoptosis is assessed, consider using GO:0043523 regulation of neuron apoptotic process. If neuron death is assessed but the cell death modality isn't defined, refer to GO:0070997 neuron death. Where non-neuronal cells are involved, and/or processes other than cell death are described, please use other terms for annotation.
tRNA methyltransferase complex (GO:0043527)
Namespace: cellular_component
Definition: A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.
tRNA (m2G10) methyltransferase complex (GO:0043528)
Namespace: cellular_component
Definition: A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p.
adenosine 5'-monophosphoramidase activity (GO:0043530)
Namespace: molecular_function
Definition: Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester.
Synonyms: adenosine 5' monophosphoramidase activity; adenosine 5'-monophosphoramidate hydrolase activity
ADP binding (GO:0043531)
Namespace: molecular_function
Definition: Binding to ADP, adenosine 5'-diphosphate.
Synonyms: adenosine 5'-diphosphate binding; adenosine diphosphate binding
angiostatin binding (GO:0043532)
Namespace: molecular_function
Definition: Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis.
inositol 1,3,4,5 tetrakisphosphate binding (GO:0043533)
Namespace: molecular_function
Definition: Binding to inositol 1,3,4,5 tetrakisphosphate.
Synonyms: InsP4 binding; IP4 binding
blood vessel endothelial cell migration (GO:0043534)
Namespace: biological_process
Definition: The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.
regulation of blood vessel endothelial cell migration (GO:0043535)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
positive regulation of blood vessel endothelial cell migration (GO:0043536)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
Synonyms: activation of blood vessel endothelial cell migration; stimulation of blood vessel endothelial cell migration; up regulation of blood vessel endothelial cell migration; up-regulation of blood vessel endothelial cell migration; upregulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration (GO:0043537)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
Synonyms: down regulation of blood vessel endothelial cell migration; down-regulation of blood vessel endothelial cell migration; downregulation of blood vessel endothelial cell migration; inhibition of blood vessel endothelial cell migration
obsolete regulation of actin phosphorylation (GO:0043538)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.
Comment: This term was obsoleted because it represents a molecular function.
protein serine/threonine kinase activator activity (GO:0043539)
Namespace: molecular_function
Definition: Binds to and increases the activity of a protein serine/threonine kinase.
Synonyms: protein ser/thr kinase activator activity
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex (GO:0043540)
Namespace: cellular_component
Definition: A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
Synonyms: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex
Comment: Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future.
UDP-N-acetylglucosamine transferase complex (GO:0043541)
Namespace: cellular_component
Definition: A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.
endothelial cell migration (GO:0043542)
Namespace: biological_process
Definition: The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
protein acylation (GO:0043543)
Namespace: biological_process
Definition: The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid.
Synonyms: protein amino acid acylation
lipoamide binding (GO:0043544)
Namespace: molecular_function
Definition: Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.
molybdopterin cofactor metabolic process (GO:0043545)
Namespace: biological_process
Definition: The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
Synonyms: Moco metabolic process; Moco metabolism; molybdopterin cofactor metabolism
molybdopterin cofactor binding (GO:0043546)
Namespace: molecular_function
Definition: Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
Synonyms: Moco binding
positive regulation of GTPase activity (GO:0043547)
Namespace: biological_process
Definition: Any process that activates or increases the activity of a GTPase.
Synonyms: activation of GTPase activity; positive regulation of ARF GTPase activity; positive regulation of Cdc42 GTPase activity; positive regulation of Rab GTPase activity; positive regulation of Rac GTPase activity; positive regulation of Ral GTPase activity; positive regulation of Ran GTPase activity; positive regulation of Rap GTPase activity; positive regulation of Ras GTPase activity; positive regulation of Rho GTPase activity; stimulation of ARF GTPase activity; stimulation of Cdc42 GTPase activity; stimulation of GTPase activity; stimulation of Rab GTPase activity; stimulation of Rac GTPase activity; stimulation of Ral GTPase activity; stimulation of Ran GTPase activity; stimulation of Rap GTPase activity; stimulation of Ras GTPase activity; stimulation of Rho GTPase activity; up regulation of ARF GTPase activity; up regulation of Cdc42 GTPase activity; up regulation of GTPase activity; up regulation of Rab GTPase activity; up regulation of Rac GTPase activity; up regulation of Ral GTPase activity; up regulation of Ran GTPase activity; up regulation of Rap GTPase activity; up regulation of Ras GTPase activity; up regulation of Rho GTPase activity; up-regulation of ARF GTPase activity; up-regulation of Cdc42 GTPase activity; up-regulation of GTPase activity; up-regulation of Rab GTPase activity; up-regulation of Rac GTPase activity; up-regulation of Ral GTPase activity; up-regulation of Ran GTPase activity; up-regulation of Rap GTPase activity; up-regulation of Ras GTPase activity; up-regulation of Rho GTPase activity; upregulation of ARF GTPase activity; upregulation of Cdc42 GTPase activity; upregulation of GTPase activity; upregulation of Rab GTPase activity; upregulation of Rac GTPase activity; upregulation of Ral GTPase activity; upregulation of Ran GTPase activity; upregulation of Rap GTPase activity; upregulation of Ras GTPase activity; upregulation of Rho GTPase activity
phosphatidylinositol 3-kinase binding (GO:0043548)
Namespace: molecular_function
Definition: Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
Synonyms: phosphoinositide 3-kinase binding; PI3K binding
regulation of kinase activity (GO:0043549)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
regulation of lipid kinase activity (GO:0043550)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.
obsolete regulation of phosphatidylinositol 3-kinase activity (GO:0043551)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.
Synonyms: regulation of phosphoinositide 3-kinase activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
Synonyms: activation of phosphatidylinositol 3-kinase activity; positive regulation of phosphoinositide 3-kinase activity; stimulation of phosphatidylinositol 3-kinase activity; up regulation of phosphatidylinositol 3-kinase activity; up-regulation of phosphatidylinositol 3-kinase activity; upregulation of phosphatidylinositol 3-kinase activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of phosphatidylinositol 3-kinase activity (GO:0043553)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
Synonyms: down regulation of phosphatidylinositol 3-kinase activity; down-regulation of phosphatidylinositol 3-kinase activity; downregulation of phosphatidylinositol 3-kinase activity; inhibition of phosphatidylinositol 3-kinase activity; negative regulation of phosphoinositide 3-kinase activity; negative regulation of PI3K activity
Comment: This term was obsoleted because it represents a molecular function.
aerobic respiration, using arsenite as electron donor (GO:0043554)
Namespace: biological_process
Definition: The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems.
regulation of translation in response to stress (GO:0043555)
Namespace: biological_process
Definition: Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
Synonyms: translational stress response
regulation of translation in response to oxidative stress (GO:0043556)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
regulation of translation in response to osmotic stress (GO:0043557)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
regulation of translational initiation in response to stress (GO:0043558)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress.
Synonyms: regulation of translation initiation in response to stress
insulin binding (GO:0043559)
Namespace: molecular_function
Definition: Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
insulin receptor substrate binding (GO:0043560)
Namespace: molecular_function
Definition: Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
Synonyms: insulin receptor substrate [protein] binding; IRS [protein] binding; IRS binding
regulation of translational initiation in response to osmotic stress (GO:0043561)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
obsolete odorant transporter activity (GO:0043563)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells.
Ku70:Ku80 complex (GO:0043564)
Namespace: cellular_component
Definition: Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.
Synonyms: Ku70:Ku80 heterodimer
sequence-specific DNA binding (GO:0043565)
Namespace: molecular_function
Definition: Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
Synonyms: sequence specific DNA binding
regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
Synonyms: regulation of IGF receptor signaling pathway; regulation of IGF receptor signalling pathway; regulation of insulin-like growth factor receptor signalling pathway