LiteFold/GO huggingface dataset:
interleukin-33-mediated signaling pathway (GO:0038172)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-33-mediated signaling pathway; IL33 signaling pathway; interleukin-33 signaling pathway; interleukin-33-mediated signalling pathway
interleukin-17A-mediated signaling pathway (GO:0038173)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-17A-mediated signaling pathway; IL17A signaling pathway; interleukin-17A signaling pathway; interleukin-17A-mediated signalling pathway
interleukin-17A receptor activity (GO:0038174)
Namespace: molecular_function
Definition: Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
negative regulation of SREBP signaling pathway in response to increased oxygen levels (GO:0038175)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels.
Synonyms: negative regulation of SREBP-mediated signaling pathway in presence of oxygen; negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels
positive regulation of SREBP signaling pathway in response to decreased oxygen levels (GO:0038176)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels.
Synonyms: positive regulation of SREBP-mediated signaling pathway in absence of oxygen; positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels
death receptor agonist activity (GO:0038177)
Namespace: molecular_function
Definition: Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.
Synonyms: death receptor activator activity
complement component C5a signaling pathway (GO:0038178)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.
Synonyms: complement component C5a-induced signaling pathway
neurotrophin signaling pathway (GO:0038179)
Namespace: biological_process
Definition: The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Synonyms: neurotrophin receptor signaling pathway
Comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
nerve growth factor signaling pathway (GO:0038180)
Namespace: biological_process
Definition: The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: nerve growth factor signalling pathway; NGF signaling pathway
Comment: Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase.
obsolete bile acid receptor activity (GO:0038181)
Namespace: molecular_function
Definition: OBSOLETE. Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile.
Comment: This term was obsoleted because it is an unnecessary grouping term.
G protein-coupled bile acid receptor activity (GO:0038182)
Namespace: molecular_function
Definition: Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: cell surface bile acid receptor; G-protein coupled bile acid receptor activity; lithocholic acid receptor activity; membrane bile acid receptor activity
bile acid signaling pathway (GO:0038183)
Namespace: biological_process
Definition: The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Comment: This term is not for direct annotation. Please use a more specific child: 'cell surface bile acid receptor signaling pathway' for GPCRs and 'intracellular bile acid receptor signaling pathway' for nuclear receptors.
adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway (GO:0038184)
Namespace: biological_process
Definition: An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to a bile acid receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
Synonyms: cell surface bile acid receptor signaling pathway; membrane bile acid receptor signaling pathway
nuclear receptor-mediated bile acid signaling pathway (GO:0038185)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by a bile acid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: BAR signaling pathway; farnesoid X receptor signaling pathway; FXR signaling pathway; intracellular bile acid receptor signaling pathway; nuclear bile acid receptor signaling pathway
bile acid nuclear receptor activity (GO:0038186)
Namespace: molecular_function
Definition: A nuclear receptor activity regulated by a bile acid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.
Synonyms: farnesoid X nuclear receptor activity; farnesoid X receptor activity; lithocholic acid receptor activity
pattern recognition receptor activity (GO:0038187)
Namespace: molecular_function
Definition: Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.
Synonyms: macrophage receptor activity; MAMP receptor activity; microbe-associated molecular pattern receptor activity; PAMP receptor activity; pathogen associated molecular pattern receptor activity; PRR; PRR activity; signaling pattern recognition receptor activity
neuropilin signaling pathway (GO:0038189)
Namespace: biological_process
Definition: The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: Npn signaling
VEGF-activated neuropilin signaling pathway (GO:0038190)
Namespace: biological_process
Definition: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: vascular endothelial growth factor-activated neuropilin signaling pathway; VEGF-Npn-1 signaling
neuropilin binding (GO:0038191)
Namespace: molecular_function
Definition: Binding to a member of the neuropilin family.
Synonyms: neuropilin-binding; Nrp binding; Nrp ligand
gastric inhibitory peptide signaling pathway (GO:0038192)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: gastric inhibitory polypeptide receptor signaling pathway; GIP signaling; glucose-dependent insulinotropic polypeptide signaling
thromboxane A2 signaling pathway (GO:0038193)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by thromboxane A2 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: TXA(2) receptor signaling; TXA2 signaling
thyroid-stimulating hormone signaling pathway (GO:0038194)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: thyrotropin signaling pathway; TSH signaling pathway
urokinase plasminogen activator signaling pathway (GO:0038195)
Namespace: biological_process
Definition: The series of molecular signals initiated by urokinase plasminogen activator binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: uPA signaling pathway
type III interferon-mediated signaling pathway (GO:0038196)
Namespace: biological_process
Definition: The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far.
Synonyms: interferon lambda signaling pathway; type III interferon signaling pathway; type III interferon-activated signaling pathway
type I interferon receptor complex (GO:0038197)
Namespace: cellular_component
Definition: A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).
Synonyms: interferon-alpha/beta receptor complex
auxin receptor activity (GO:0038198)
Namespace: molecular_function
Definition: Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone).
ethylene receptor activity (GO:0038199)
Namespace: molecular_function
Definition: Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity.
Synonyms: C2H4 receptor activity; ethylene response sensor
ethylene receptor histidine kinase activity (GO:0038200)
Namespace: molecular_function
Definition: Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.
TORC2 signaling (GO:0038203)
Namespace: biological_process
Definition: A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
Synonyms: TORC2 signal transduction
pronephric field specification (GO:0039003)
Namespace: biological_process
Definition: The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop.
Synonyms: pronephric kidney field specification
specification of pronephric proximal tubule identity (GO:0039004)
Namespace: biological_process
Definition: The process in which the proximal tubule of the pronephric nephron acquires its identity.
specification of pronephric tubule identity (GO:0039005)
Namespace: biological_process
Definition: The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity.
pronephric nephron tubule formation (GO:0039006)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros.
Synonyms: pronephric tubule formation; pronephros tubule formation
pronephric nephron morphogenesis (GO:0039007)
Namespace: biological_process
Definition: The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros.
pronephric nephron tubule morphogenesis (GO:0039008)
Namespace: biological_process
Definition: The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron.
rectal diverticulum development (GO:0039009)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior.
Synonyms: pronephric rectal diverticulum development
specification of pronephric distal tubule identity (GO:0039010)
Namespace: biological_process
Definition: The process in which the distal tubule of the pronephric nephron acquires its identity.
pronephric proximal tubule morphogenesis (GO:0039011)
Namespace: biological_process
Definition: The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.
Synonyms: pronephros proximal tubule morphogenesis
pronephric sinus development (GO:0039012)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules.
pronephric distal tubule morphogenesis (GO:0039013)
Namespace: biological_process
Definition: The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.
obsolete cell differentiation involved in pronephros development (GO:0039014)
Namespace: biological_process
Definition: OBSOLETE. The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state.
Synonyms: cell differentiation involved in pronephric kidney development
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
cell proliferation involved in pronephros development (GO:0039015)
Namespace: biological_process
Definition: The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros.
Synonyms: cell proliferation involved in pronephric kidney development
obsolete cell-cell signaling involved in pronephros development (GO:0039016)
Namespace: biological_process
Definition: OBSOLETE. Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ.
Synonyms: cell-cell signaling involved in pronephric kidney development; cell-cell signalling involved in pronephros development
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete pattern specification involved in pronephros development (GO:0039017)
Namespace: biological_process
Definition: OBSOLETE. Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate.
Synonyms: pattern specification involved in pronephric kidney development
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
pronephric nephron development (GO:0039019)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros.
pronephric nephron tubule development (GO:0039020)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct.
pronephric glomerulus development (GO:0039021)
Namespace: biological_process
Definition: The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
Comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus.
pronephric duct development (GO:0039022)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.
pronephric duct morphogenesis (GO:0039023)
Namespace: biological_process
Definition: The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.
obsolete suppression by virus of host type I interferon production (GO:0039501)
Namespace: biological_process
Definition: OBSOLETE. Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms: negative regulation by virus of host type I interferon production; suppression by virus of host interferon type I production; suppression by virus of host type I IFN production
Comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host type I interferon-mediated signaling pathway ; GO:0039502.
symbiont-mediated suppression of host type I interferon-mediated signaling pathway (GO:0039502)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms: inhibition of host interferon signaling pathway by virus; negative regulation by virus of host type I interferon-mediated signaling pathway; suppression by virus of host type I IFN-mediated signaling pathway; suppression by virus of host type I interferon-mediated signaling pathway; suppression by virus of host type I interferon-mediated signalling pathway
obsolete suppression by virus of host innate immune response (GO:0039503)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense.
Synonyms: inhibition of host innate immune response by virus; negative regulation by virus of host innate immune response; negative regulation by virus of host innate immunity; suppression by virus of host innate immunity
Comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host innate immune response ; GO:0052170.
symbiont-mediated suppression of host adaptive immune response (GO:0039504)
Namespace: biological_process
Definition: A process by which a symbiont inhibits or disrupts the normal execution of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
Synonyms: inhibition of host adaptive immune response by virus; negative regulation of host adaptive immune response; negative regulation of host adaptive immunity; suppression by virus of host adaptive immune response; suppression of host acquired immune response
symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II (GO:0039505)
Namespace: biological_process
Definition: A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class II protein complex.
Synonyms: inhibition of host MHC class II molecule presentation by virus; suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II
obsolete modulation by virus of host molecular function (GO:0039506)
Namespace: biological_process
Definition: OBSOLETE. The process in which a virus effects a change in the function of a host protein via a direct interaction.
Synonyms: modification by virus of host protein function
Comment: This term was obsoleted because it represents a molecular function.
obsolete suppression by virus of host molecular function (GO:0039507)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein.
Synonyms: down regulation by virus of host protein function; down-regulation by virus of host protein function; inhibition by virus of host protein function; inhibition of host protein function; negative regulation by virus of host molecular function; negative regulation by virus of host protein function
Comment: This term was obsoleted because it represents a molecular function.
obsolete suppression by virus of host receptor activity (GO:0039508)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor.
Synonyms: down-regulation by virus of host receptor activity; downregulation by virus of host receptor activity; inhibition by virus of host receptor activity; negative regulation by virus of host receptor activity; suppression by virus of host receptor function; viral inhibition of host receptor
Comment: This term was obsoleted because it represents a molecular function.
obsolete suppression by virus of host ATP-dependent RNA helicase activity (GO:0039510)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity.
Synonyms: down-regulation by virus of host ATP-dependent RNA helicase activity; downregulation by virus of host ATP-dependent RNA helicase activity; inhibition by virus of host ATP-dependent RNA helicase activity; negative regulation by virus of host ATP-dependent RNA helicase activity
Comment: This term was obsoleted because it represents a molecular function.