LiteFold/GO huggingface dataset:
corticotrophin-releasing factor receptor activity (GO:0015056)
Namespace: molecular_function
Definition: Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.
thrombin-activated receptor activity (GO:0015057)
Namespace: molecular_function
Definition: A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
Synonyms: thrombin receptor activity; thrombin receptor activity, G-protein coupled
obsolete epidermal growth factor-like module containing hormone receptor activity (GO:0015058)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: EGF-like module containing hormone receptor activity; Egr1 hormone receptor; epidermal growth factor-like module containing hormone receptor activity
Comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
obsolete blue-sensitive opsin (GO:0015059)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: blue-sensitive opsin
Comment: This term was made obsolete because it refers to a class of proteins.
obsolete green-sensitive opsin (GO:0015060)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: green-sensitive opsin
Comment: This term was made obsolete because it refers to a class of proteins.
obsolete red-sensitive opsin (GO:0015061)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: red-sensitive opsin
Comment: This term was made obsolete because it refers to a class of proteins.
obsolete violet-sensitive opsin (GO:0015062)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: violet-sensitive opsin
Comment: This term was made obsolete because it refers to a class of proteins.
obsolete long-wave-sensitive opsin (GO:0015063)
Namespace: molecular_function
Definition: OBSOLETE. An opsin with maximal absorption above 500 nm.
Synonyms: long-wave-sensitive opsin
Comment: This term was made obsolete because it refers to a class of proteins.
obsolete UV-sensitive opsin (GO:0015064)
Namespace: molecular_function
Definition: OBSOLETE. An opsin with maximal absorption below 400 nm.
Synonyms: UV-sensitive opsin
Comment: This term was made obsolete because it refers to a class of proteins.
alpha-amylase inhibitor activity (GO:0015066)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of alpha-amylase.
glycine amidinotransferase activity (GO:0015068)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate.
Synonyms: arginine-glycine amidinotransferase activity; arginine-glycine transamidinase activity; glycine transamidinase activity; L-arginine:glycine amidinotransferase activity
obsolete toxin activity (GO:0015070)
Namespace: molecular_function
Definition: OBSOLETE. Acts as to cause injury to other living organisms.
Synonyms: toxin activity
Comment: This term was made obsolete because it represents a classification of molecules and not a molecular function.
obsolete phosphatidylinositol 3-kinase, class I, catalyst activity (GO:0015072)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
Synonyms: phosphatidylinositol 3-kinase, class I, catalyst activity
Comment: This term was made obsolete because it represents a class of gene products.
DNA integration (GO:0015074)
Namespace: biological_process
Definition: The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
monoatomic ion transmembrane transporter activity (GO:0015075)
Namespace: molecular_function
Definition: Enables the transfer of an ion from one side of a membrane to the other.
Synonyms: ion transmembrane transporter activity; ion transporter activity
obsolete heavy metal ion transporter activity (GO:0015076)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn.
Synonyms: heavy metal ion transporter activity
Comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
proton transmembrane transporter activity (GO:0015078)
Namespace: molecular_function
Definition: Enables the transfer of a proton from one side of a membrane to the other.
Synonyms: hydrogen ion transmembrane transporter activity; proton transporter activity
potassium ion transmembrane transporter activity (GO:0015079)
Namespace: molecular_function
Definition: Enables the transfer of potassium ions (K+) from one side of a membrane to the other.
Synonyms: potassium transporter activity; potassium uptake permease activity; potassium uptake transmembrane transporter activity
silver ion transmembrane transporter activity (GO:0015080)
Namespace: molecular_function
Definition: Enables the transfer of silver (Ag+) ions from one side of a membrane to the other.
Synonyms: silver transporter activity
sodium ion transmembrane transporter activity (GO:0015081)
Namespace: molecular_function
Definition: Enables the transfer of sodium ions (Na+) from one side of a membrane to the other.
Synonyms: sodium transporter activity
calcium ion transmembrane transporter activity (GO:0015085)
Namespace: molecular_function
Definition: Enables the transfer of calcium (Ca) ions from one side of a membrane to the other.
cadmium ion transmembrane transporter activity (GO:0015086)
Namespace: molecular_function
Definition: Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other.
Synonyms: zinc, cadmium uptake permease activity; zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
cobalt ion transmembrane transporter activity (GO:0015087)
Namespace: molecular_function
Definition: Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other.
Synonyms: cobalt, zinc uptake permease activity; zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
high-affinity copper ion transmembrane transporter activity (GO:0015089)
Namespace: molecular_function
Definition: Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity copper ion transmembrane transporter activity; high affinity copper transporter activity
low-affinity ferric iron ion transmembrane transporter activity (GO:0015090)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
Synonyms: low affinity iron ion transmembrane transporter activity; low affinity iron transporter activity
ferric iron transmembrane transporter activity (GO:0015091)
Namespace: molecular_function
Definition: Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
Comment: Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity.
high-affinity ferric iron transmembrane transporter activity (GO:0015092)
Namespace: molecular_function
Definition: Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity ferric uptake transmembrane transporter activity
ferrous iron transmembrane transporter activity (GO:0015093)
Namespace: molecular_function
Definition: Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
Synonyms: ferrous iron uptake transmembrane transporter activity
lead ion transmembrane transporter activity (GO:0015094)
Namespace: molecular_function
Definition: Enables the transfer of lead (Pb) ions from one side of a membrane to the other.
Synonyms: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
magnesium ion transmembrane transporter activity (GO:0015095)
Namespace: molecular_function
Definition: Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.
obsolete manganese resistance permease activity (GO:0015096)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: manganese resistance permease activity
Comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition.
mercury ion transmembrane transporter activity (GO:0015097)
Namespace: molecular_function
Definition: Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other.
molybdate ion transmembrane transporter activity (GO:0015098)
Namespace: molecular_function
Definition: Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid.
Synonyms: molybdate transporter activity
nickel cation transmembrane transporter activity (GO:0015099)
Namespace: molecular_function
Definition: Enables the transfer of nickel (Ni) cations from one side of a membrane to the other.
Synonyms: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
vanadium ion transmembrane transporter activity (GO:0015100)
Namespace: molecular_function
Definition: Enables the transfer of vanadium (V) ions from one side of a membrane to the other.
obsolete organic cation transmembrane transporter activity (GO:0015101)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.
Comment: The reason for obsoletion is that this term was an unnecessary and confusing grouping term.
antimonite transmembrane transporter activity (GO:0015104)
Namespace: molecular_function
Definition: Enables the transfer of antimonite from one side of a membrane to the other.
arsenite transmembrane transporter activity (GO:0015105)
Namespace: molecular_function
Definition: Enables the transfer of arsenite from one side of a membrane to the other.
chlorate transmembrane transporter activity (GO:0015107)
Namespace: molecular_function
Definition: Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other.
chloride transmembrane transporter activity (GO:0015108)
Namespace: molecular_function
Definition: Enables the transfer of chloride ions from one side of a membrane to the other.
Synonyms: ATP-dependent chloride transmembrane transporter activity; ATPase-coupled chloride transmembrane transporter activity; chloride ABC transporter; chloride ion transmembrane transporter activity; chloride transporting ATPase activity; chloride-transporting ATPase activity
chromate transmembrane transporter activity (GO:0015109)
Namespace: molecular_function
Definition: Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3.
cyanate transmembrane transporter activity (GO:0015110)
Namespace: molecular_function
Definition: Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other.
iodide transmembrane transporter activity (GO:0015111)
Namespace: molecular_function
Definition: Enables the transfer of iodide ions from one side of a membrane to the other.
nitrate transmembrane transporter activity (GO:0015112)
Namespace: molecular_function
Definition: Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other.
Synonyms: nitrite/nitrate porter activity
nitrite transmembrane transporter activity (GO:0015113)
Namespace: molecular_function
Definition: Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other.
Synonyms: nitrite/nitrate porter activity
silicate transmembrane transporter activity (GO:0015115)
Namespace: molecular_function
Definition: Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates.
sulfate transmembrane transporter activity (GO:0015116)
Namespace: molecular_function
Definition: Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.
Synonyms: sulfate permease activity; sulphate transporter activity
thiosulfate transmembrane transporter activity (GO:0015117)
Namespace: molecular_function
Definition: Enables the transfer of thiosulfate ions, HS2O3(1-), from one side of a membrane to the other.
Synonyms: thiosulfate permease activity; thiosulphate transporter activity
hexose phosphate transmembrane transporter activity (GO:0015119)
Namespace: molecular_function
Definition: Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule.
phosphoglycerate transmembrane transporter activity (GO:0015120)
Namespace: molecular_function
Definition: Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis.
phosphoenolpyruvate:phosphate antiporter activity (GO:0015121)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out).
Synonyms: phosphoenolpyruvate/phosphate translocator; PPT
acetate transmembrane transporter activity (GO:0015123)
Namespace: molecular_function
Definition: Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid.
allantoate transmembrane transporter activity (GO:0015124)
Namespace: molecular_function
Definition: Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen.
bile acid transmembrane transporter activity (GO:0015125)
Namespace: molecular_function
Definition: Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
bilirubin transmembrane transporter activity (GO:0015127)
Namespace: molecular_function
Definition: Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile.
lactate transmembrane transporter activity (GO:0015129)
Namespace: molecular_function
Definition: Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
Synonyms: monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
oxaloacetate transmembrane transporter activity (GO:0015131)
Namespace: molecular_function
Definition: Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other.
prostaglandin transmembrane transporter activity (GO:0015132)
Namespace: molecular_function
Definition: Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
Synonyms: prostaglandin/thromboxane transporter activity
uronic acid transmembrane transporter activity (GO:0015133)
Namespace: molecular_function
Definition: Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose.
hexuronate transmembrane transporter activity (GO:0015134)
Namespace: molecular_function
Definition: Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6.
Synonyms: hexuronide transmembrane transporter activity
sialic acid transmembrane transporter activity (GO:0015136)
Namespace: molecular_function
Definition: Enables the transfer of sialic acid from one side of a membrane to the other.
citrate transmembrane transporter activity (GO:0015137)
Namespace: molecular_function
Definition: Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboxylate, from one side of a membrane to the other.
Synonyms: tricarboxylate transport protein
fumarate transmembrane transporter activity (GO:0015138)
Namespace: molecular_function
Definition: Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
Synonyms: dicarboxylate (succinate/fumarate/malate) antiporter activity
alpha-ketoglutarate transmembrane transporter activity (GO:0015139)
Namespace: molecular_function
Definition: Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle.
Synonyms: 2-oxoglutarate transporter activity
malate transmembrane transporter activity (GO:0015140)
Namespace: molecular_function
Definition: Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
Synonyms: dicarboxylate (succinate/fumarate/malate) antiporter activity
succinate transmembrane transporter activity (GO:0015141)
Namespace: molecular_function
Definition: Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other.
Synonyms: dicarboxylate (succinate/fumarate/malate) antiporter activity
tricarboxylic acid transmembrane transporter activity (GO:0015142)
Namespace: molecular_function
Definition: Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups.
Synonyms: sodium:dicarboxylate/tricarboxylate symporter activity
urate transmembrane transporter activity (GO:0015143)
Namespace: molecular_function
Definition: Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.
Synonyms: uric acid transmembrane transporter activity
carbohydrate transmembrane transporter activity (GO:0015144)
Namespace: molecular_function
Definition: Enables the transfer of carbohydrate from one side of a membrane to the other.
Synonyms: carbohydrate transporter activity; sugar transporter
pentose transmembrane transporter activity (GO:0015146)
Namespace: molecular_function
Definition: Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms.
L-arabinose transmembrane transporter activity (GO:0015147)
Namespace: molecular_function
Definition: Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc.
Synonyms: L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity
D-xylose transmembrane transporter activity (GO:0015148)
Namespace: molecular_function
Definition: Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides.
hexose transmembrane transporter activity (GO:0015149)
Namespace: molecular_function
Definition: Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.
fucose transmembrane transporter activity (GO:0015150)
Namespace: molecular_function
Definition: Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose.
alpha-glucoside transmembrane transporter activity (GO:0015151)
Namespace: molecular_function
Definition: Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.
glucose-6-phosphate transmembrane transporter activity (GO:0015152)
Namespace: molecular_function
Definition: Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6.
rhamnose transmembrane transporter activity (GO:0015153)
Namespace: molecular_function
Definition: Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids.
Synonyms: ATP-dependent rhamnose transmembrane transporter activity; ATPase-coupled rhamnose transmembrane transporter activity; rhamnose-transporting ATPase activity
disaccharide transmembrane transporter activity (GO:0015154)
Namespace: molecular_function
Definition: Enables the transfer of disaccharide from one side of a membrane to the other.
lactose transmembrane transporter activity (GO:0015155)
Namespace: molecular_function
Definition: Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals.
Synonyms: lactose permease activity; lactose/glucose efflux transporter activity