LiteFold/GO huggingface dataset:
nuclear SCF ubiquitin ligase complex (GO:0043224)
Namespace: cellular_component
Definition: A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms: nuclear cullin complex; nuclear SCF complex; nuclear Skp1/Cul1/F-box protein complex
obsolete ATPase-coupled inorganic anion transmembrane transporter activity (GO:0043225)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in).
Synonyms: anion ABC transporter; anion transmembrane-transporting ATPase activity; anion-transporting ATPase activity; ATP-dependent anion transmembrane transporter activity; ATPase-coupled anion transmembrane transporter activity
Comment: The reason for obsoletion is that this term was an unnecessary and confusing grouping term.
organelle (GO:0043226)
Namespace: cellular_component
Definition: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle (GO:0043227)
Namespace: cellular_component
Definition: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
Synonyms: membrane-enclosed organelle
membraneless organelle (GO:0043228)
Namespace: cellular_component
Definition: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
Synonyms: biological condensate; membrane-less organelle; non-membrane-bounded organelle; non-membrane-enclosed organelle
intracellular organelle (GO:0043229)
Namespace: cellular_component
Definition: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
extracellular organelle (GO:0043230)
Namespace: cellular_component
Definition: Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.
intracellular membrane-bounded organelle (GO:0043231)
Namespace: cellular_component
Definition: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
Synonyms: intracellular membrane-enclosed organelle
intracellular membraneless organelle (GO:0043232)
Namespace: cellular_component
Definition: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
Synonyms: intracellular non-membrane-bounded organelle; intracellular non-membrane-enclosed organelle
organelle lumen (GO:0043233)
Namespace: cellular_component
Definition: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
signaling receptor complex (GO:0043235)
Namespace: cellular_component
Definition: Any protein complex that binds a signaling molecule such as a hormone, neurotransmitter, molecular pattern recognition receptor (PAMPs and DAMPS), or an intracellular messenger to initiate a change in cell function.
Synonyms: receptor complex
laminin binding (GO:0043236)
Namespace: molecular_function
Definition: Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells.
Synonyms: laminin-2 binding; laminin-4 binding
laminin-1 binding (GO:0043237)
Namespace: molecular_function
Definition: Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.
Synonyms: laminin-111 binding
Fanconi anaemia nuclear complex (GO:0043240)
Namespace: cellular_component
Definition: A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.
Synonyms: FA complex; FA core complex; FA nuclear complex; Fanconi anaemia complex
negative regulation of protein-containing complex disassembly (GO:0043242)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
Synonyms: down regulation of protein complex disassembly; down-regulation of protein complex disassembly; downregulation of protein complex disassembly; inhibition of protein complex disassembly; negative regulation of protein complex disassembly
positive regulation of protein-containing complex disassembly (GO:0043243)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
Synonyms: activation of protein complex disassembly; positive regulation of protein complex disassembly; stimulation of protein complex disassembly; up regulation of protein complex disassembly; up-regulation of protein complex disassembly; upregulation of protein complex disassembly
regulation of protein-containing complex disassembly (GO:0043244)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
Synonyms: regulation of protein complex disassembly
extraorganismal space (GO:0043245)
Namespace: cellular_component
Definition: The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms.
telomere maintenance in response to DNA damage (GO:0043247)
Namespace: biological_process
Definition: Any process that occur in response to the presence of critically short or damaged telomeres.
Synonyms: DNA damage response, telomere maintenance
proteasome assembly (GO:0043248)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a mature, active proteasome complex.
Synonyms: 26S proteasome assembly; proteasome complex assembly; proteasome maturation
erythrocyte maturation (GO:0043249)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
Synonyms: RBC maturation; red blood cell maturation
obsolete sodium-dependent organic anion transmembrane transporter activity (GO:0043250)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner.
Comment: The reason for obsoletion is that this term was an unnecessary and confusing grouping term.
sodium-dependent organic anion transport (GO:0043251)
Namespace: biological_process
Definition: The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
sodium-independent organic anion transport (GO:0043252)
Namespace: biological_process
Definition: The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
chloroplast ribosome (GO:0043253)
Namespace: cellular_component
Definition: A ribosome contained within a chloroplast.
regulation of protein-containing complex assembly (GO:0043254)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of protein complex assembly.
Synonyms: regulation of protein complex assembly
regulation of carbohydrate biosynthetic process (GO:0043255)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.
Synonyms: regulation of carbohydrate anabolism; regulation of carbohydrate biosynthesis; regulation of carbohydrate formation; regulation of carbohydrate synthesis
laminin trimer (GO:0043256)
Namespace: cellular_component
Definition: A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.
Synonyms: laminin complex
laminin-411 trimer (GO:0043257)
Namespace: cellular_component
Definition: A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.
Synonyms: laminin-411 complex; laminin-8 complex
laminin-421 trimer (GO:0043258)
Namespace: cellular_component
Definition: A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains.
Synonyms: laminin-421 complex; laminin-9 complex
laminin-511 trimer (GO:0043259)
Namespace: cellular_component
Definition: A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.
Synonyms: laminin-10 complex; laminin-511 complex
laminin-521 trimer (GO:0043260)
Namespace: cellular_component
Definition: A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains.
Synonyms: laminin-11 complex; laminin-521 complex
laminin-213 trimer (GO:0043261)
Namespace: cellular_component
Definition: A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains.
Synonyms: laminin-12 complex; laminin-213 complex
ADP phosphatase activity (GO:0043262)
Namespace: molecular_function
Definition: Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+.
Synonyms: adenosine diphosphatase activity; adenosine-diphosphatase activity; ADP diphosphatase activity; ADPase; ADPase activity; ATP diphosphohydrolase activity; ATP-diphosphatase activity
cellulosome (GO:0043263)
Namespace: cellular_component
Definition: An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose.
Synonyms: scaffoldin complex
obsolete ectoplasm (GO:0043265)
Namespace: cellular_component
Definition: OBSOLETE. Granule free cytoplasm, lying immediately below the plasma membrane.
Comment: The reason for obsoletion is that this term was added in error.
regulation of potassium ion transport (GO:0043266)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: regulation of K+ conductance; regulation of K+ transport; regulation of potassium conductance; regulation of potassium ion conductance; regulation of potassium transport
negative regulation of potassium ion transport (GO:0043267)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of potassium ion transport; down-regulation of potassium ion transport; downregulation of potassium ion transport; inhibition of potassium ion transport; negative regulation of K+ transport; negative regulation of potassium ion conductance; negative regulation of potassium transport; regulation of K+ conductance; regulation of potassium conductance; transmembrane conductance regulator activity
positive regulation of potassium ion transport (GO:0043268)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of potassium ion transport; positive regulation of K+ conductance; positive regulation of K+ transport; positive regulation of potassium conductance; positive regulation of potassium ion conductance; positive regulation of potassium transport; stimulation of potassium ion transport; up regulation of potassium ion transport; up-regulation of potassium ion transport; upregulation of potassium ion transport
regulation of monoatomic ion transport (GO:0043269)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: regulation of ion transport
positive regulation of monoatomic ion transport (GO:0043270)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of ion transport; stimulation of ion transport; up regulation of ion transport; up-regulation of ion transport; upregulation of ion transport
negative regulation of monoatomic ion transport (GO:0043271)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of ion transport; down-regulation of ion transport; downregulation of ion transport; inhibition of ion transport; negative regulation of ion transport
obsolete ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance (GO:0043272)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance.
Synonyms: ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance; ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance; ethylene formation during jasmonic acid and ethylene-dependent systemic resistance; ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM.
CTPase activity (GO:0043273)
Namespace: molecular_function
Definition: Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction.
Synonyms: CTPase activity, coupled; cytidine triphosphatase activity; single-stranded DNA-dependent CTPase activity
phospholipase binding (GO:0043274)
Namespace: molecular_function
Definition: Binding to a phospholipase.
obsolete glutamate carboxypeptidase II activity (GO:0043275)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu.
Synonyms: acetylaspartylglutamate dipeptidase activity; folate hydrolase activity; folylpolyglutamate hydrolase activity; glutamate carboxypeptidase II activity; membrane glutamate carboxypeptidase; mGCP; microsomal gamma-glutamyl carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase activity; N-acetylated-alpha-linked-amino dipeptidase activity; N-acetylated-gamma-linked-acidic dipeptidase (NAALADase); N-acetylated-gamma-linked-acidic dipeptidase activity; NAALA dipeptidase activity; NAALADase activity; prostate-specific membrane antigen; prostrate-specific membrane antigen; PSM antigen; PSMA; pteroylpoly-gamma-glutamate carboxypeptidase activity; pteroylpoly-gamma-glutamate hydrolase activity; pteroylpolygammaglutamyl hydrolase activity; pteroylpolyglutamate hydrolase activity; pteroylpolyglutamic acid hydrolase activity; rat NAAG peptidase
Comment: This term was made obsolete because it represents a gene product.
anoikis (GO:0043276)
Namespace: biological_process
Definition: Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
Synonyms: detachment induced cell death; suspension induced apoptosis
apoptotic cell clearance (GO:0043277)
Namespace: biological_process
Definition: The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
Synonyms: apoptotic cell removal; efferocytosis; programmed cell clearance
Comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells.
response to morphine (GO:0043278)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
response to alkaloid (GO:0043279)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
obsolete positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
Synonyms: activation of caspase activity; positive regulation of caspase activity; stimulation of caspase activity; up regulation of caspase activity; up-regulation of caspase activity; upregulation of caspase activity
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
obsolete regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.
Synonyms: regulation of caspase activation; regulation of caspase activity
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
chordate pharyngeal muscle development (GO:0043282)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx.
poly(3-hydroxyalkanoate) binding (GO:0043287)
Namespace: molecular_function
Definition: Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.
Synonyms: PHA binding
obsolete apocarotenoid metabolic process (GO:0043288)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid.
Synonyms: apo carotenoid metabolic process; apocarotenoid metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
apocarotenoid biosynthetic process (GO:0043289)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid.
Synonyms: apo carotenoid biosynthetic process; apocarotenoid anabolism; apocarotenoid biosynthesis; apocarotenoid formation; apocarotenoid synthesis
apocarotenoid catabolic process (GO:0043290)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid.
Synonyms: apo carotenoid catabolic process; apocarotenoid breakdown; apocarotenoid catabolism; apocarotenoid degradation
RAVE complex (GO:0043291)
Namespace: cellular_component
Definition: A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.
Synonyms: regulator of the (H+)-ATPase of the vacuolar and endosomal membranes
contractile muscle fiber (GO:0043292)
Namespace: cellular_component
Definition: Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
Synonyms: contractile fibre
apoptosome (GO:0043293)
Namespace: cellular_component
Definition: A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.
mitochondrial glutamate synthase complex (NADH) (GO:0043294)
Namespace: cellular_component
Definition: A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.
glutathione binding (GO:0043295)
Namespace: molecular_function
Definition: Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
apical junction complex (GO:0043296)
Namespace: cellular_component
Definition: A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
Synonyms: apical cell junction complex; apical junction
apical junction assembly (GO:0043297)
Namespace: biological_process
Definition: The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.
Synonyms: apical junction complex assembly
leukocyte degranulation (GO:0043299)
Namespace: biological_process
Definition: The regulated exocytosis of secretory granules by a leukocyte.
Synonyms: immune cell degranulation; immune cell granule exocytosis; leucocyte degranulation; leukocyte granule exocytosis