LiteFold/GO huggingface dataset:
vascular associated smooth muscle cell fate specification (GO:0097082)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
Synonyms: vascular smooth muscle cell fate specification
vascular associated smooth muscle cell fate determination (GO:0097083)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
Synonyms: vascular smooth muscle cell fate determination
interferon regulatory factor 3-interferon regulatory factor 5 complex (GO:0097085)
Namespace: cellular_component
Definition: An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5.
Synonyms: IRF3:IRF5 complex
amniotic stem cell differentiation (GO:0097086)
Namespace: biological_process
Definition: The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone.
interleukin-17A production (GO:0097087)
Namespace: biological_process
Definition: The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: IL-17A production; interleukin-17A biosynthetic process
interleukin-17F production (GO:0097088)
Namespace: biological_process
Definition: The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: IL-17F production
methyl-branched fatty acid metabolic process (GO:0097089)
Namespace: biological_process
Definition: The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain.
Synonyms: methyl-branched fatty acid metabolism
presynaptic membrane organization (GO:0097090)
Namespace: biological_process
Definition: A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
Synonyms: pre-synaptic membrane organization; presynaptic membrane organisation
Comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
synaptic vesicle clustering (GO:0097091)
Namespace: biological_process
Definition: The process that results in grouping synaptic vesicles in presynaptic structures.
polyacyltrehalose biosynthetic process (GO:0097093)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid.
Synonyms: polyacyltrehalose anabolism; polyacyltrehalose biosynthesis; polyacyltrehalose formation; polyacyltrehalose synthesis
frontonasal suture morphogenesis (GO:0097095)
Namespace: biological_process
Definition: The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized.
Synonyms: nasofrontal suture morphogenesis
facial suture morphogenesis (GO:0097096)
Namespace: biological_process
Definition: The process in which any suture between facial bones is generated and organized.
nasal suture morphogenesis (GO:0097097)
Namespace: biological_process
Definition: The process in which the nasal suture is generated and organized.
Synonyms: internasal suture morphogenesis
DNA/RNA hybrid annealing activity (GO:0097098)
Namespace: molecular_function
Definition: An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops.
structural constituent of albumen (GO:0097099)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo.
Synonyms: structural constituent of egg white
supercoiled DNA binding (GO:0097100)
Namespace: molecular_function
Definition: Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.
blood vessel endothelial cell fate specification (GO:0097101)
Namespace: biological_process
Definition: The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.
endothelial tip cell fate specification (GO:0097102)
Namespace: biological_process
Definition: The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels.
Synonyms: angiogenic tip cell fate specification
endothelial stalk cell fate specification (GO:0097103)
Namespace: biological_process
Definition: The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout.
Synonyms: angiogenic stalk cell fate specification
presynaptic membrane assembly (GO:0097105)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
Synonyms: pre-synaptic membrane assembly
Comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
postsynaptic density organization (GO:0097106)
Namespace: biological_process
Definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
Synonyms: post synaptic density organization; post-synaptic density organization; postsynaptic density organisation; PSD organization
hedgehog family protein binding (GO:0097108)
Namespace: molecular_function
Definition: Binding to a member of the hedgehog protein family, signaling proteins involved in development.
neuroligin family protein binding (GO:0097109)
Namespace: molecular_function
Definition: Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.
scaffold protein binding (GO:0097110)
Namespace: molecular_function
Definition: Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
endoplasmic reticulum-Golgi intermediate compartment organization (GO:0097111)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment.
Synonyms: endoplasmic reticulum-Golgi intermediate compartment organisation; endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis; ER-Golgi intermediate compartment organization; ERGIC organization
gamma-aminobutyric acid receptor clustering (GO:0097112)
Namespace: biological_process
Definition: The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane.
Synonyms: GABA receptor clustering
AMPA glutamate receptor clustering (GO:0097113)
Namespace: biological_process
Definition: The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.
Synonyms: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering; AMPA receptor clustering
NMDA glutamate receptor clustering (GO:0097114)
Namespace: biological_process
Definition: The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane.
Synonyms: N-methyl-D-aspartate receptor clustering; NMDA receptor clustering
neurexin clustering involved in presynaptic membrane assembly (GO:0097115)
Namespace: biological_process
Definition: The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals.
Synonyms: neurexin clustering; Nrxn clustering; presynaptic neurexin clustering
gephyrin clustering involved in postsynaptic density assembly (GO:0097116)
Namespace: biological_process
Definition: The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses.
Synonyms: Geph clustering
guanylate kinase-associated protein clustering (GO:0097117)
Namespace: biological_process
Definition: The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons.
Synonyms: GKAP clustering
neuroligin clustering involved in postsynaptic membrane assembly (GO:0097118)
Namespace: biological_process
Definition: The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons.
Synonyms: neuroligin clustering; Nlgn clustering; postsynaptic neuroligin clustering
postsynaptic density protein 95 clustering (GO:0097119)
Namespace: biological_process
Definition: The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins.
Synonyms: Dlg4 clustering; post-synaptic density protein 95 clustering; PSD-95 clustering
receptor localization to synapse (GO:0097120)
Namespace: biological_process
Definition: Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
Synonyms: receptor localisation to synapse
cyclin A1-CDK1 complex (GO:0097121)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin A2-CDK1 complex (GO:0097122)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin A1-CDK2 complex (GO:0097123)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin A2-CDK2 complex (GO:0097124)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin B1-CDK1 complex (GO:0097125)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin B2-CDK1 complex (GO:0097126)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin B3-CDK2 complex (GO:0097127)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin D1-CDK4 complex (GO:0097128)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin D2-CDK4 complex (GO:0097129)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin D3-CDK4 complex (GO:0097130)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin D1-CDK6 complex (GO:0097131)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin D2-CDK6 complex (GO:0097132)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin D3-CDK6 complex (GO:0097133)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin E1-CDK2 complex (GO:0097134)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin E2-CDK2 complex (GO:0097135)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
Bcl-2 family protein complex (GO:0097136)
Namespace: cellular_component
Definition: A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.
BAD-BCL-xl complex (GO:0097137)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
BAD-BCL-2 complex (GO:0097138)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
BID-BCL-2 complex (GO:0097139)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
BIM-BCL-xl complex (GO:0097140)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
PUMA-BCL-xl complex (GO:0097143)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
BAX complex (GO:0097144)
Namespace: cellular_component
Definition: An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators.
BAK complex (GO:0097145)
Namespace: cellular_component
Definition: An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators.
NOXA-BCL-xl complex (GO:0097146)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
NOXA-BCL-2 complex (GO:0097147)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
BCL-2 complex (GO:0097148)
Namespace: cellular_component
Definition: A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators.
centralspindlin complex (GO:0097149)
Namespace: cellular_component
Definition: A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).
neuronal stem cell population maintenance (GO:0097150)
Namespace: biological_process
Definition: Any process in by an organism or tissue maintains a population of neuronal stem cells.
mesenchymal cell apoptotic process (GO:0097152)
Namespace: biological_process
Definition: Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
Synonyms: mesenchymal cell apoptosis
obsolete cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.
Synonyms: caspase activity; metacaspase activity
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
GABAergic neuron differentiation (GO:0097154)
Namespace: biological_process
Definition: The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron.
fasciculation of sensory neuron axon (GO:0097155)
Namespace: biological_process
Definition: The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
fasciculation of motor neuron axon (GO:0097156)
Namespace: biological_process
Definition: The collection of motor neuron axons into a bundle of rods, known as a fascicle.
pre-mRNA intronic binding (GO:0097157)
Namespace: molecular_function
Definition: Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA).
Synonyms: pre-messenger RNA intronic binding; pre-mRNA intron binding
pre-mRNA intronic pyrimidine-rich binding (GO:0097158)
Namespace: molecular_function
Definition: Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA).
Synonyms: pre-messenger RNA intronic pyrimidine-rich binding
obsolete organic cyclic compound binding (GO:0097159)
Namespace: molecular_function
Definition: OBSOLETE. Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
polychlorinated biphenyl binding (GO:0097160)
Namespace: molecular_function
Definition: Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings.
Synonyms: PCB binding; polychlorobiphenyl binding