LiteFold/GO huggingface dataset:
RES complex (GO:0070274)
Namespace: cellular_component
Definition: A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p.
Synonyms: pre-mRNA retention and splicing complex
aerobic ammonia oxidation to nitrite via pyruvic oxime (GO:0070275)
Namespace: biological_process
Definition: The metabolic process in which ammonia (NH4+) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite.
halogen metabolic process (GO:0070276)
Namespace: biological_process
Definition: The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds.
Synonyms: halogen metabolism
vitamin B6 binding (GO:0070279)
Namespace: molecular_function
Definition: Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate.
pyridoxal binding (GO:0070280)
Namespace: molecular_function
Definition: Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6.
pyridoxamine binding (GO:0070281)
Namespace: molecular_function
Definition: Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6.
pyridoxine binding (GO:0070282)
Namespace: molecular_function
Definition: Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6.
phosphomethylpyrimidine synthase activity (GO:0070284)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + CO + 5'-deoxyadenosine + formate + L-methionine + 3 H+.
Synonyms: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity; HMP-P synthase activity; ThiC
pigment cell development (GO:0070285)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.
axonemal dynein complex assembly (GO:0070286)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
Synonyms: dynein arm assembly
ferritin receptor activity (GO:0070287)
Namespace: molecular_function
Definition: Combining with ferritin, and delivering ferritin into the cell via endocytosis.
Synonyms: ferritin complex receptor activity
obsolete extracellular ferritin complex (GO:0070289)
Namespace: cellular_component
Definition: OBSOLETE. A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains.
Synonyms: serum ferritin complex
Comment: The reason for obsoletion is that this term represents a cellular component and its location.
N-acylphosphatidylethanolamine-specific phospholipase D activity (GO:0070290)
Namespace: molecular_function
Definition: Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
Synonyms: N-acyl-phosphatidylethanolamine-specific phospholipase D activity; NAPE-specific phospholipase D activity
N-acylphosphatidylethanolamine metabolic process (GO:0070292)
Namespace: biological_process
Definition: The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
Synonyms: N-acylphosphatidylethanolamine metabolism; NAPE metabolic process; NAPE metabolism
renal absorption (GO:0070293)
Namespace: biological_process
Definition: A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).
Synonyms: nephron absorption; renal reabsorption
renal sodium ion absorption (GO:0070294)
Namespace: biological_process
Definition: A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
Synonyms: nephron sodium ion absorption; renal sodium ion reabsorption
renal water absorption (GO:0070295)
Namespace: biological_process
Definition: A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
Synonyms: nephron water absorption; renal water reabsorption
sarcoplasmic reticulum calcium ion transport (GO:0070296)
Namespace: biological_process
Definition: The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.
regulation of phosphorelay signal transduction system (GO:0070297)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.
Synonyms: regulation of histidyl-aspartyl phosphorelay; regulation of two-component signal transduction system; regulation of two-component signal transduction system (phosphorelay)
negative regulation of phosphorelay signal transduction system (GO:0070298)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.
Synonyms: down regulation of two-component signal transduction; down-regulation of two-component signal transduction; downregulation of two-component signal transduction; inhibition of two-component signal transduction; negative regulation of histidyl-aspartyl phosphorelay; negative regulation of two-component signal transduction system (phosphorelay)
positive regulation of phosphorelay signal transduction system (GO:0070299)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.
Synonyms: activation of two-component signal transduction; positive regulation of histidyl-aspartyl phosphorelay; positive regulation of two-component signal transduction system (phosphorelay); stimulation of two-component signal transduction; up regulation of two-component signal transduction; up-regulation of two-component signal transduction; upregulation of two-component signal transduction
phosphatidic acid binding (GO:0070300)
Namespace: molecular_function
Definition: Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
Synonyms: phosphatidate binding
cellular response to hydrogen peroxide (GO:0070301)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
regulation of stress-activated protein kinase signaling cascade (GO:0070302)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade.
Synonyms: regulation of SAPK signaling pathway; regulation of stress-activated protein kinase signaling pathway; regulation of stress-activated protein kinase signalling pathway
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms: activation of stress-activated protein kinase signaling pathway; positive regulation of SAPK signaling pathway; positive regulation of stress-activated protein kinase signaling pathway; positive regulation of stress-activated protein kinase signalling pathway; stimulation of stress-activated protein kinase signaling pathway; up regulation of stress-activated protein kinase signaling pathway; up-regulation of stress-activated protein kinase signaling pathway; upregulation of stress-activated protein kinase signaling pathway
response to cGMP (GO:0070305)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.
Synonyms: response to 3',5' cGMP; response to 3',5'-cGMP; response to cyclic GMP; response to guanosine 3',5'-cyclophosphate
lens fiber cell development (GO:0070307)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
Synonyms: lens fibre cell development
lens fiber cell fate commitment (GO:0070308)
Namespace: biological_process
Definition: The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
Synonyms: lens fibre cell fate commitment
lens fiber cell morphogenesis (GO:0070309)
Namespace: biological_process
Definition: The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
Synonyms: elongation of lens fiber cell; lens fiber cell morphogenesis during differentiation; lens fibre cell morphogenesis
ATR-ATRIP complex (GO:0070310)
Namespace: cellular_component
Definition: A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.
Synonyms: Mec1-Lcd1 complex; Rad3-Rad26 complex
nucleosomal methylation activator complex (GO:0070311)
Namespace: cellular_component
Definition: A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription.
Synonyms: NUMAC
RAD52-ERCC4-ERCC1 complex (GO:0070312)
Namespace: cellular_component
Definition: A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.
Comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
RGS6-DNMT1-DMAP1 complex (GO:0070313)
Namespace: cellular_component
Definition: A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.
G1 to G0 transition (GO:0070314)
Namespace: biological_process
Definition: A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence.
Synonyms: cell cycle quiescence; establishment of cell quiescence; G1/G0 transition; stationary phase
G1 to G0 transition involved in cell differentiation (GO:0070315)
Namespace: biological_process
Definition: A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation.
Synonyms: G1/G0 transition involved in cell differentiation
regulation of G0 to G1 transition (GO:0070316)
Namespace: biological_process
Definition: A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase.
negative regulation of G0 to G1 transition (GO:0070317)
Namespace: biological_process
Definition: A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
Synonyms: maintenance of cell cycle quiescence; maintenance of cell quiescence; maintenance of G0 arrest; maintenance of G0 phase
positive regulation of G0 to G1 transition (GO:0070318)
Namespace: biological_process
Definition: A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase.
Golgi to plasma membrane transport vesicle (GO:0070319)
Namespace: cellular_component
Definition: A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
Synonyms: Golgi to plasma membrane constitutive secretory pathway transport vesicle; Golgi-plasma membrane transport vesicle
inward rectifier potassium channel inhibitor activity (GO:0070320)
Namespace: molecular_function
Definition: Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.
obsolete regulation of translation in response to nitrogen starvation (GO:0070321)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen.
Comment: This term was obsoleted because it was redundant with GO:1903832 ; regulation of cellular response to amino acid starvation.
obsolete negative regulation of translation in response to nitrogen starvation (GO:0070322)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen.
Synonyms: down regulation of translation in response to nitrogen starvation; down-regulation of translation in response to nitrogen starvation; downregulation of translation in response to nitrogen starvation; inhibition of translation in response to nitrogen starvation
Comment: This term was obsoleted because it was redundant with GO:1903574 ; negative regulation of cellular response to amino acid starvation.
obsolete positive regulation of translation in response to nitrogen starvation (GO:0070323)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen.
Synonyms: activation of translation in response to nitrogen starvation; stimulation of translation in response to nitrogen starvation; up regulation of translation in response to nitrogen starvation; up-regulation of translation in response to nitrogen starvation; upregulation of translation in response to nitrogen starvation
Comment: This term was obsoleted because it was redundant with GO:1903833 ; positive regulation of cellular response to amino acid starvation.
thyroid hormone binding (GO:0070324)
Namespace: molecular_function
Definition: Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
Synonyms: thyroxine binding; triiodothyronine binding
lipoprotein particle receptor binding (GO:0070325)
Namespace: molecular_function
Definition: Binding to a lipoprotein particle receptor.
very-low-density lipoprotein particle receptor binding (GO:0070326)
Namespace: molecular_function
Definition: Binding to a very-low-density lipoprotein receptor.
Synonyms: apolipoprotein E receptor binding; very-low-density lipoprotein receptor binding; VLDL receptor binding; VLDLR binding
thyroid hormone transport (GO:0070327)
Namespace: biological_process
Definition: The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: thyroxine transport; triiodothyronine transport
triglyceride homeostasis (GO:0070328)
Namespace: biological_process
Definition: Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
Synonyms: triacylglycerol homeostasis
tRNA seleno-modification (GO:0070329)
Namespace: biological_process
Definition: The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule.
Synonyms: tRNA base modification to selenouridine
aromatase activity (GO:0070330)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone.
Synonyms: estrogen synthetase activity
CD20-Lck-Fyn complex (GO:0070331)
Namespace: cellular_component
Definition: A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn.
CD20-Lck-Lyn-Fyn complex (GO:0070332)
Namespace: cellular_component
Definition: A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn.
alpha6-beta4 integrin-Shc-Grb2 complex (GO:0070333)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2.
Synonyms: ITGA6-ITGB4-SHC-GRB2 complex
alpha6-beta4 integrin-laminin 5 complex (GO:0070334)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5.
Synonyms: alpha6-beta4 integrin-laminin-332 complex; ITGA6-ITGB4-LAMA5 complex
aspartate binding (GO:0070335)
Namespace: molecular_function
Definition: Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4.
Synonyms: aspartic acid binding
flap-structured DNA binding (GO:0070336)
Namespace: molecular_function
Definition: Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule.
3'-flap-structured DNA binding (GO:0070337)
Namespace: molecular_function
Definition: Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule.
5'-flap-structured DNA binding (GO:0070338)
Namespace: molecular_function
Definition: Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers.
response to bacterial lipopeptide (GO:0070339)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus.
detection of bacterial lipopeptide (GO:0070340)
Namespace: biological_process
Definition: The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal.
fat cell proliferation (GO:0070341)
Namespace: biological_process
Definition: The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.
Synonyms: adipocyte proliferation; adipose cell proliferation
brown fat cell proliferation (GO:0070342)
Namespace: biological_process
Definition: The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species.
Synonyms: brown adipocyte proliferation; brown adipose cell proliferation
white fat cell proliferation (GO:0070343)
Namespace: biological_process
Definition: The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population.
Synonyms: white adipocyte proliferation; white adipose cell proliferation
regulation of fat cell proliferation (GO:0070344)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of fat cell proliferation.
Synonyms: regulation of adipocyte proliferation; regulation of adipose cell proliferation
negative regulation of fat cell proliferation (GO:0070345)
Namespace: biological_process
Definition: Any process that stops or decreases the rate or extent of fat cell proliferation.
Synonyms: down regulation of fat cell proliferation; down-regulation of fat cell proliferation; downregulation of fat cell proliferation; inhibition of fat cell proliferation; negative regulation of adipocyte proliferation; negative regulation of adipose cell proliferation
negative regulation of brown fat cell proliferation (GO:0070348)
Namespace: biological_process
Definition: Any process that stops or decreases the rate or extent of brown fat cell proliferation.
Synonyms: down regulation of brown fat cell proliferation; down-regulation of brown fat cell proliferation; downregulation of brown fat cell proliferation; inhibition of brown fat cell proliferation; negative regulation of brown adipocyte proliferation; negative regulation of brown adipose cell proliferation
positive regulation of brown fat cell proliferation (GO:0070349)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of brown fat cell proliferation.
Synonyms: activation of brown fat cell proliferation; positive regulation of brown adipocyte proliferation; positive regulation of brown adipose cell proliferation; stimulation of brown fat cell proliferation; up regulation of brown fat cell proliferation; up-regulation of brown fat cell proliferation; upregulation of brown fat cell proliferation
positive regulation of white fat cell proliferation (GO:0070352)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of white fat cell proliferation.
Synonyms: activation of white fat cell proliferation; positive regulation of white adipocyte proliferation; positive regulation of white adipose cell proliferation; stimulation of white fat cell proliferation; up regulation of white fat cell proliferation; up-regulation of white fat cell proliferation; upregulation of white fat cell proliferation
GATA1-TAL1-TCF3-Lmo2 complex (GO:0070353)
Namespace: cellular_component
Definition: A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
GATA2-TAL1-TCF3-Lmo2 complex (GO:0070354)
Namespace: cellular_component
Definition: A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.