LiteFold/GO huggingface dataset:
methionine-tRNA ligase activity (GO:0004825)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
Synonyms: L-methionine:tRNAMet ligase (AMP-forming); methionine translase activity; methionyl-transfer ribonucleate synthetase activity; methionyl-transfer ribonucleic acid synthetase activity; methionyl-transfer RNA synthetase activity; methionyl-tRNA synthetase activity; MetRS activity
phenylalanine-tRNA ligase activity (GO:0004826)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
Synonyms: L-phenylalanine:tRNAPhe ligase (AMP-forming) activity; L-phenylalanyl-tRNA synthetase activity; phenylalanine translase activity; phenylalanine-tRNA synthetase activity; phenylalanyl-transfer ribonucleate synthetase activity; phenylalanyl-transfer RNA ligase activity; phenylalanyl-transfer RNA synthetase activity; phenylalanyl-tRNA ligase activity; phenylalanyl-tRNA synthetase activity
proline-tRNA ligase activity (GO:0004827)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
Synonyms: L-proline:tRNAPro ligase (AMP-forming); proline translase activity; prolinyl-tRNA ligase activity; prolyl-s-RNA synthetase activity; prolyl-transfer ribonucleate synthetase activity; prolyl-transfer ribonucleic acid synthetase activity; prolyl-transferRNA synthetase activity; prolyl-tRNA synthetase activity
serine-tRNA ligase activity (GO:0004828)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). Also catalyzes the formation of L-seryl-tRNA(Sec) from tRNA(Sec), the special tRNA for selenocysteine.
Synonyms: L-serine:tRNASer ligase (AMP-forming); serine translase activity; SerRS activity; seryl-transfer ribonucleate synthetase activity; seryl-transfer ribonucleic acid synthetase activity; seryl-transfer RNA synthetase activity; seryl-tRNA synthetase activity
threonine-tRNA ligase activity (GO:0004829)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
Synonyms: L-threonine:tRNAThr ligase (AMP-forming); threonine translase activity; threonine-transfer ribonucleate synthetase activity; threonyl ribonucleic synthetase activity; threonyl-transfer ribonucleate synthetase activity; threonyl-transfer ribonucleic acid synthetase activity; threonyl-transfer RNA synthetase activity; threonyl-tRNA synthetase activity; TRS
tryptophan-tRNA ligase activity (GO:0004830)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
Synonyms: L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity; L-tryptophan-tRNATrp ligase (AMP-forming); L-tryptophan:tRNATrp ligase (AMP-forming); TrpRS activity; tryptophan translase activity; tryptophanyl ribonucleic synthetase activity; tryptophanyl-transfer ribonucleate synthetase activity; tryptophanyl-transfer ribonucleic acid synthetase activity; tryptophanyl-transfer ribonucleic synthetase activity; tryptophanyl-transfer RNA synthetase activity; tryptophanyl-tRNA synthase activity; tryptophanyl-tRNA synthetase activity
tyrosine-tRNA ligase activity (GO:0004831)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+.
Synonyms: L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity; L-tyrosine-tRNATyr ligase (AMP-forming); L-tyrosine:tRNATyr ligase (AMP-forming); tyrosine translase activity; tyrosine tRNA synthetase activity; tyrosine-transfer ribonucleate synthetase activity; tyrosine-transfer RNA ligase activity; tyrosyl-transfer ribonucleate synthetase activity; tyrosyl-transfer ribonucleic acid synthetase activity; tyrosyl-transfer RNA synthetase activity; tyrosyl-tRNA ligase activity; tyrosyl-tRNA synthetase activity
valine-tRNA ligase activity (GO:0004832)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+.
Synonyms: L-valine:tRNAVal ligase (AMP-forming); valine transfer ribonucleate ligase activity; valine translase activity; valyl-transfer ribonucleate synthetase activity; valyl-transfer ribonucleic acid synthetase activity; valyl-transfer RNA synthetase activity; valyl-tRNA synthetase activity
L-tryptophan 2,3-dioxygenase activity (GO:0004833)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
Synonyms: indolamine 2,3-dioxygenase activity; indoleamine-pyrrole 2,3-dioxygenase activity; L-tryptophan pyrrolase activity; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing); TDO; tryptamin 2,3-dioxygenase activity; tryptamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity; tryptophan oxygenase activity; tryptophan peroxidase activity; tryptophan pyrrolase activity
tryptophan synthase activity (GO:0004834)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O.
Synonyms: indoleglycerol phosphate aldolase activity; L-serine hydro-lyase (adding indoleglycerol-phosphate); L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]; L-tryptophan synthetase activity; tryptophan desmolase activity; tryptophan synthetase activity
tubulin-tyrosine ligase activity (GO:0004835)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
Synonyms: alpha-tubulin:L-tyrosine ligase (ADP-forming); TTL activity; tubulinyl-tyrosine ligase activity
tyramine-beta hydroxylase activity (GO:0004836)
Namespace: molecular_function
Definition: Catalysis of the reaction: tyramine + L-ascorbate + O2 = (R)-octopamine + L-dehydroascorbate + H2O.
tyrosine decarboxylase activity (GO:0004837)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tyrosine = tyramine + CO2.
Synonyms: L-(-)-tyrosine apodecarboxylase activity; L-tyrosine carboxy-lyase (tyramine-forming); L-tyrosine carboxy-lyase activity; L-tyrosine decarboxylase activity
L-tyrosine:2-oxoglutarate transaminase activity (GO:0004838)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate.
Synonyms: glutamic phenylpyruvic aminotransferase activity; glutamic-hydroxyphenylpyruvic transaminase activity; L-phenylalanine 2-oxoglutarate aminotransferase activity; L-tyrosine aminotransferase activity; L-tyrosine transaminase activity; L-tyrosine-2-oxoglutarate transaminase activity; L-tyrosine:2-oxoglutarate aminotransferase activity; phenylalanine aminotransferase activity; phenylalanine transaminase activity; phenylalanine-alpha-ketoglutarate transaminase activity; phenylpyruvate transaminase activity; phenylpyruvic acid transaminase activity; TyrAT activity; tyrosine aminotransferase activity; tyrosine transaminase activity; tyrosine-2-ketoglutarate aminotransferase activity; tyrosine-alpha-ketoglutarate aminotransferase activity; tyrosine-alpha-ketoglutarate transaminase activity
ubiquitin activating enzyme activity (GO:0004839)
Namespace: molecular_function
Definition: Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
Synonyms: E1 ubiquitin-activating enzyme
Comment: The ubiquitin activating enzyme catalyzes a ligation reaction.
ubiquitin-protein transferase activity (GO:0004842)
Namespace: molecular_function
Definition: Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
Synonyms: E2; E3; ubiquitin conjugating enzyme activity; ubiquitin ligase activity; ubiquitin protein ligase activity; ubiquitin protein-ligase activity; ubiquitin-conjugating enzyme activity
cysteine-type deubiquitinase activity (GO:0004843)
Namespace: molecular_function
Definition: An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
Synonyms: deubiquitinase; deubiquitinase activity; deubiquitinating enzyme; deubiquitylase; thiol-dependent deubiquitinase; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; ubiquitin C-terminal hydrolase; ubiquitin hydrolase activity; ubiquitin-specific protease activity; ubiquitinyl hydrolase 1 activity; ubiquitinyl hydrolase activity; UBP; UCH2
uracil DNA N-glycosylase activity (GO:0004844)
Namespace: molecular_function
Definition: Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
Synonyms: uracil-DNA glycosylase activity
uracil phosphoribosyltransferase activity (GO:0004845)
Namespace: molecular_function
Definition: Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil.
Synonyms: UMP diphosphorylase activity; UMP pyrophosphorylase activity; UMP:diphosphate phospho-alpha-D-ribosyltransferase activity; UMP:pyrophosphate phosphoribosyltransferase activity; UPRTase activity; uridine 5'-phosphate pyrophosphorylase activity; uridine monophosphate pyrophosphorylase activity; uridylate pyrophosphorylase activity; uridylic pyrophosphorylase activity
urate oxidase activity (GO:0004846)
Namespace: molecular_function
Definition: Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2.
Synonyms: urate:oxygen oxidoreductase activity; uric acid oxidase activity; uricase activity; uricase II activity
urea carboxylase activity (GO:0004847)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate.
Synonyms: ATP--urea amidolyase activity; UALase activity; UCA activity; urea amidolyase activity; urea carboxylase (hydrolysing); urea carboxylase (hydrolyzing) activity; urea:carbon-dioxide ligase (ADP-forming); urease (ATP-hydrolysing); urease (ATP-hydrolyzing) activity
ureidoglycolate hydrolase activity (GO:0004848)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4.
Synonyms: ureidoglycolate amidohydrolase activity
Comment: Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.1.116, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.1.116) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.1.116 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
uridine kinase activity (GO:0004849)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + uridine = ADP + UMP.
Synonyms: uridine phosphokinase activity; uridine-cytidine kinase activity
uridine phosphorylase activity (GO:0004850)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
Synonyms: pyrimidine phosphorylase activity; UPase activity; UPH; UrdPase activity; uridine:phosphate alpha-D-ribosyltransferase activity
uroporphyrin-III C-methyltransferase activity (GO:0004851)
Namespace: molecular_function
Definition: Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+.
Synonyms: adenosylmethionine-uroporphyrinogen III methyltransferase activity; CobA; CysG; S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity; S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity; S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity; SirA; SUMT activity; urogen III methylase activity; uroporphyrinogen III methylase activity; uroporphyrinogen methyltransferase activity; uroporphyrinogen-III C-methyltransferase activity; uroporphyrinogen-III methylase activity; uroporphyrinogen-III methyltransferase activity
uroporphyrinogen-III synthase activity (GO:0004852)
Namespace: molecular_function
Definition: Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.
Synonyms: hydroxymethylbilane hydro-lyase (cyclizing) activity; hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming); porphobilinogenase activity; URO-synthase activity; uroporphyrinogen III cosynthase activity; uroporphyrinogen isomerase activity; uroporphyrinogen-III cosynthase activity; uroporphyrinogen-III cosynthetase activity
uroporphyrinogen decarboxylase activity (GO:0004853)
Namespace: molecular_function
Definition: Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.
Synonyms: porphyrinogen carboxy-lyase activity; porphyrinogen decarboxylase activity; uroporphyrinogen III decarboxylase activity; uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming); uroporphyrinogen-III carboxy-lyase activity
xanthine dehydrogenase activity (GO:0004854)
Namespace: molecular_function
Definition: Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
Synonyms: NAD-xanthine dehydrogenase activity; xanthine oxidoreductase activity; xanthine-NAD oxidoreductase activity; xanthine/NAD(+) oxidoreductase activity; xanthine/NAD+ oxidoreductase activity; xanthine:NAD+ oxidoreductase activity
xanthine oxidase activity (GO:0004855)
Namespace: molecular_function
Definition: Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2.
Synonyms: hypoxanthine-xanthine oxidase activity; schardinger enzyme; Schardinger enzyme activity; xanthine oxidoreductase activity; xanthine:O2 oxidoreductase activity; xanthine:oxygen oxidoreductase activity; xanthine:xanthine oxidase activity
D-xylulokinase activity (GO:0004856)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H+.
Synonyms: ATP:D-xylulose 5-phosphotransferase activity; xylulokinase (phosphorylating); xylulokinase activity; xylulose kinase activity
enzyme inhibitor activity (GO:0004857)
Namespace: molecular_function
Definition: A molecular function regulator that reduces a catalytic activity.
Synonyms: metalloenzyme inhibitor activity
Comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.
protein kinase inhibitor activity (GO:0004860)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a protein kinase.
cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.
Synonyms: CDK inhibitor; cyclin dependent kinase inhibitor; cyclin dependent protein kinase inhibitor activity; cyclin-dependent kinase inhibitor; cyclin-dependent protein kinase inhibitor activity
cAMP-dependent protein kinase inhibitor activity (GO:0004862)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
protein phosphatase inhibitor activity (GO:0004864)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a protein phosphatase.
Synonyms: phosphoprotein phosphatase inhibitor activity; protein phosphatase 2 inhibitor activity; protein phosphatase type 2A inhibitor activity
protein serine/threonine phosphatase inhibitor activity (GO:0004865)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.
endopeptidase inhibitor activity (GO:0004866)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of an endopeptidase.
Synonyms: alpha-2 macroglobulin; endoproteinase inhibitor; proteinase inhibitor
serine-type endopeptidase inhibitor activity (GO:0004867)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.
Synonyms: serine protease inhibitor activity; serine proteinase inhibitor activity; serpin activity
obsolete serpin (GO:0004868)
Namespace: molecular_function
Definition: OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin.
Synonyms: serpin
Comment: This term was made obsolete because it represents a class of gene products.
cysteine-type endopeptidase inhibitor activity (GO:0004869)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase.
Synonyms: cystatin; cysteine protease inhibitor activity; thiol protease inhibitor
obsolete signal transducer activity (GO:0004871)
Namespace: molecular_function
Definition: OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
Synonyms: hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity; quorum sensing response regulator activity; quorum sensing signal generator activity
Comment: This term was obsoleted because it was not clearly defined and is not a useful grouping term.
asialoglycoprotein receptor activity (GO:0004873)
Namespace: molecular_function
Definition: Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane.
obsolete aryl hydrocarbon receptor activity (GO:0004874)
Namespace: molecular_function
Definition: OBSOLETE. Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.
Comment: This term was obsoleted because it represents a gene product.
complement receptor activity (GO:0004875)
Namespace: molecular_function
Definition: Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: anaphylatoxin receptor activity
Comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
complement component C3a receptor activity (GO:0004876)
Namespace: molecular_function
Definition: Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: C3a anaphylatoxin receptor activity
complement component C3b receptor activity (GO:0004877)
Namespace: molecular_function
Definition: Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
complement component C5a receptor activity (GO:0004878)
Namespace: molecular_function
Definition: Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: C5a anaphylatoxin receptor activity
nuclear receptor activity (GO:0004879)
Namespace: molecular_function
Definition: A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.
Synonyms: 1,25-(OH)2D3 receptor activity; 9-cis retinoic acid receptor activity; androgen receptor activity; calcitriol receptor activity; ecdysteroid hormone receptor activity; estrogen nuclear receptor activity; glucocorticoid receptor activity; juvenile hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-dependent nuclear receptor activity; ligand-dependent transcription factor activity; nuclear hormone receptor; retinoic acid receptor activity; retinoid-X receptor activity; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding; RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding; RXR; thyroid hormone receptor activity; vitamin A receptor activity; vitamin D receptor activity; vitamin D3 receptor activity
Comment: Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
nuclear glucocorticoid receptor activity (GO:0004883)
Namespace: molecular_function
Definition: A nuclear receptor activity regulated by glucocorticoid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.
Synonyms: glucocorticoid receptor activity
transmembrane signaling receptor activity (GO:0004888)
Namespace: molecular_function
Definition: Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Synonyms: transmembrane receptor activity; transmembrane signalling receptor activity
Comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
GABA-A receptor activity (GO:0004890)
Namespace: molecular_function
Definition: Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
Synonyms: ionotropic GABA receptor activity
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.