LiteFold/GO huggingface dataset:
nematode larval development (GO:0002119)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
obsolete predatory behavior (GO:0002120)
Namespace: biological_process
Definition: OBSOLETE. Aggressive behavior involving attack on prey by a predator.
Synonyms: predatory aggression; predatory aggressive behavior
Comment: This term was obsoleted because it is outside the scope of GO.
inter-male aggressive behavior (GO:0002121)
Namespace: biological_process
Definition: Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.
Synonyms: inter-male aggression
fear-induced aggressive behavior (GO:0002122)
Namespace: biological_process
Definition: Aggressive behavior associated with attempts to flee from a threat.
Synonyms: fear-induced aggression
irritable aggressive behavior (GO:0002123)
Namespace: biological_process
Definition: Aggressive behavior induced by frustration and directed against an available target.
Synonyms: irritable aggression
territorial aggressive behavior (GO:0002124)
Namespace: biological_process
Definition: Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.
Synonyms: territorial aggression
maternal aggressive behavior (GO:0002125)
Namespace: biological_process
Definition: Aggressive behavior of a female to protect her offspring from a threat.
Synonyms: maternal aggression
Comment: Paternal aggression also exists. Serves to protect the offspring from intruders.
instrumental aggressive behavior (GO:0002126)
Namespace: biological_process
Definition: Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation.
Synonyms: instrumental aggression
tRNA wobble base cytosine methylation (GO:0002127)
Namespace: biological_process
Definition: The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.
Synonyms: wobble position m5C biosynthesis
tRNA nucleoside ribose methylation (GO:0002128)
Namespace: biological_process
Definition: The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position.
wobble position guanine ribose methylation (GO:0002129)
Namespace: biological_process
Definition: The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
wobble position ribose methylation (GO:0002130)
Namespace: biological_process
Definition: The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position.
wobble position cytosine ribose methylation (GO:0002131)
Namespace: biological_process
Definition: The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
wobble position uridine ribose methylation (GO:0002132)
Namespace: biological_process
Definition: The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.
polycystin complex (GO:0002133)
Namespace: cellular_component
Definition: A stable heterodimeric complex composed of polycystin-1 and polycystin-2.
Comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant).
UTP binding (GO:0002134)
Namespace: molecular_function
Definition: Binding to UTP, uridine 5'-triphosphate.
CTP binding (GO:0002135)
Namespace: molecular_function
Definition: Binding to CTP, cytidine 5'-triphosphate.
tRNA wobble base lysidine biosynthesis (GO:0002136)
Namespace: biological_process
Definition: The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine.
Comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP.
retinoic acid biosynthetic process (GO:0002138)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms: retinoic acid anabolic process; retinoic acid biosynthesis
stereocilia coupling link (GO:0002139)
Namespace: cellular_component
Definition: A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.
stereocilia ankle link (GO:0002141)
Namespace: cellular_component
Definition: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.
stereocilia ankle link complex (GO:0002142)
Namespace: cellular_component
Definition: A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.
tRNA wobble position uridine thiolation (GO:0002143)
Namespace: biological_process
Definition: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
Synonyms: tRNA wobble uridine thiolation; wobble position s2U biosynthesis
Comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
cytosolic tRNA wobble base thiouridylase complex (GO:0002144)
Namespace: cellular_component
Definition: A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets.
Synonyms: Ctu1-Ctu2 complex; tRNA thiouridylase
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity (GO:0002145)
Namespace: molecular_function
Definition: Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+.
Synonyms: HMP-PP diphosphatase; HMP-PP pyrophosphatase
obsolete steroid hormone receptor import into nucleus (GO:0002146)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus.
Synonyms: steroid hormone receptor nuclear translocation
Comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
obsolete glucocorticoid receptor import into nucleus (GO:0002147)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus.
Synonyms: glucocorticoid receptor nuclear translocation
Comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
obsolete hypochlorous acid metabolic process (GO:0002148)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving hypochlorous acid.
Synonyms: HClO metabolic process; HOCl metabolic process; hypochlorite metabolic process; hypochlorous acid metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
hypochlorous acid biosynthetic process (GO:0002149)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of hypochlorous acid.
Synonyms: HClO biosynthetic process; HOCl biosynthetic process; hypochlorite biosynthetic process; hypochlorous acid biosynthesis
Comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils.
hypochlorous acid catabolic process (GO:0002150)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of hypochlorous acid.
Synonyms: HClO catabolic process; HOCl catabolic process; hypochlorite catabolic process; hypochlorous acid catabolism
G-quadruplex RNA binding (GO:0002151)
Namespace: molecular_function
Definition: Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
Synonyms: G quadruplex binding; G quartet binding; G quartet RNA binding; G-quartet binding
Comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure.
bile acid conjugation (GO:0002152)
Namespace: biological_process
Definition: The process in which bile acids are covalently linked to taurine or glycine.
Comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine).
steroid receptor RNA activator RNA binding (GO:0002153)
Namespace: molecular_function
Definition: Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
Synonyms: SRA binding
Comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken).
thyroid hormone receptor signaling pathway (GO:0002154)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by a thyroid hormone  binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: thyroid hormone mediated signalling pathway
negative regulation of thyroid hormone receptor signaling pathway (GO:0002156)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway.
Synonyms: negative regulation of thyroid hormone mediated signaling pathway; negative regulation of thyroid hormone mediated signalling pathway
osteoclast proliferation (GO:0002158)
Namespace: biological_process
Definition: The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.
desmosome maintenance (GO:0002160)
Namespace: biological_process
Definition: The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
Comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
aminoacyl-tRNA deacylase activity (GO:0002161)
Namespace: molecular_function
Definition: The hydrolysis of an incorrectly aminoacylated tRNA.
Synonyms: amino acid proofreading activity; aminoacyl-tRNA editing activity; aminoacyl-tRNA hydrolysis activity
dystroglycan binding (GO:0002162)
Namespace: molecular_function
Definition: Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).
Synonyms: alpha-dystroglycan binding; beta-dystroglycan binding
larval development (GO:0002164)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.
instar larval or pupal development (GO:0002165)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.
VRK3/VHR/ERK complex (GO:0002167)
Namespace: cellular_component
Definition: A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.
instar larval development (GO:0002168)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.
obsolete 3-methylcrotonyl-CoA carboxylase complex, mitochondrial (GO:0002169)
Namespace: cellular_component
Definition: OBSOLETE. A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.
Synonyms: mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme; mitochondrial MCCC complex; mitochondrial methylcrotonoyl-CoA carboxylase complex
Comment: The reason for obsoletion is that this term is equivalent to GO:1905202 methylcrotonoyl-CoA carboxylase complex.
high-affinity IgA receptor activity (GO:0002170)
Namespace: molecular_function
Definition: Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: high affinity IgA receptor activity
low-affinity IgA receptor activity (GO:0002171)
Namespace: molecular_function
Definition: Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: low affinity IgA receptor activity
high-affinity IgM receptor activity (GO:0002172)
Namespace: molecular_function
Definition: Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: high affinity IgM receptor activity
low-affinity IgM receptor activity (GO:0002173)
Namespace: molecular_function
Definition: Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: low affinity IgM receptor activity
mammary stem cell proliferation (GO:0002174)
Namespace: biological_process
Definition: The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ.
protein localization to paranode region of axon (GO:0002175)
Namespace: biological_process
Definition: A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.
Synonyms: protein localisation to paranode region of axon
manchette (GO:0002177)
Namespace: cellular_component
Definition: A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
palmitoyltransferase complex (GO:0002178)
Namespace: cellular_component
Definition: A protein complex with palmitoyltransferase activity.
homodimeric serine palmitoyltransferase complex (GO:0002179)
Namespace: cellular_component
Definition: A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.
Comment: This complex occurs primarily in bacteria.
5-lipoxygenase complex (GO:0002180)
Namespace: cellular_component
Definition: An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.
cytoplasmic translation (GO:0002181)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
Comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.
cytoplasmic translational initiation (GO:0002183)
Namespace: biological_process
Definition: The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
cytoplasmic translational termination (GO:0002184)
Namespace: biological_process
Definition: The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
creatine kinase complex (GO:0002185)
Namespace: cellular_component
Definition: A protein complex having creatine kinase activity.
cytosolic creatine kinase complex (GO:0002186)
Namespace: cellular_component
Definition: A dimeric protein complex having creatine kinase activity.
mitochondrial creatine kinase complex (GO:0002187)
Namespace: cellular_component
Definition: An octomeric protein complex having creatine kinase activity.
translation reinitiation (GO:0002188)
Namespace: biological_process
Definition: A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.
ribose phosphate diphosphokinase complex (GO:0002189)
Namespace: cellular_component
Definition: A protein complex having ribose phosphate diphosphokinase activity.
Synonyms: phosphoribosylpyrophosphate synthetase complex; PRPP synthetase complex
Comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits.
cap-independent translational initiation (GO:0002190)
Namespace: biological_process
Definition: The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation.
cap-dependent translational initiation (GO:0002191)
Namespace: biological_process
Definition: The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.
IRES-dependent translational initiation of linear mRNA (GO:0002192)
Namespace: biological_process
Definition: The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation.
MAML1-RBP-Jkappa- ICN1 complex (GO:0002193)
Namespace: cellular_component
Definition: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms: MAML1-CSL-ICN1; MAML1-CSL-Notch1 complex; MAML1-RBP-Jkappa-Notch1 complex
hepatocyte cell migration (GO:0002194)
Namespace: biological_process
Definition: The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.
Ser-tRNA(Ala) deacylase activity (GO:0002196)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala).
xanthine dehydrogenase complex (GO:0002197)
Namespace: cellular_component
Definition: A homodimeric protein complex having xanthine dehydrogenase activity.
obsolete S/G2 transition of mitotic cell cycle (GO:0002198)
Namespace: biological_process
Definition: OBSOLETE. The transition from a cell in the S phase to the G2 phase.
Synonyms: S/G2 transition of mitotic cell cycle
Comment: This term was made obsolete because it does not refer to a real biological process.
zona pellucida receptor complex (GO:0002199)
Namespace: cellular_component
Definition: A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
Synonyms: sperm protein complex I
somatic diversification of DSCAM-based immune receptors (GO:0002201)
Namespace: biological_process
Definition: The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects.
Comment: Note that this type of immune receptor may not be limited to insects.
somatic diversification of variable lymphocyte receptors of jawless fish (GO:0002202)
Namespace: biological_process
Definition: The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish.
Comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762).
proteolysis by cytosolic proteases associated with antigen processing and presentation (GO:0002203)
Namespace: biological_process
Definition: The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation.
Comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497).