LiteFold/GO huggingface dataset:
HLA-B specific inhibitory MHC class I receptor activity (GO:0030109)
Namespace: molecular_function
Definition: Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.
HLA-C specific inhibitory MHC class I receptor activity (GO:0030110)
Namespace: molecular_function
Definition: Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte.
glycocalyx (GO:0030112)
Namespace: cellular_component
Definition: A carbohydrate rich layer at the outermost periphery of a cell.
slime layer (GO:0030114)
Namespace: cellular_component
Definition: A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids.
S-layer (GO:0030115)
Namespace: cellular_component
Definition: A crystalline protein layer surrounding some bacteria.
glial cell-derived neurotrophic factor receptor binding (GO:0030116)
Namespace: molecular_function
Definition: A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.
Synonyms: glial cell line-derived neurotrophic factor receptor binding; glial cell line-derived neurotrophic factor receptor ligand
membrane coat (GO:0030117)
Namespace: cellular_component
Definition: Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.
AP-type membrane coat adaptor complex (GO:0030119)
Namespace: cellular_component
Definition: Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa).
Synonyms: clathrin adaptor
vesicle coat (GO:0030120)
Namespace: cellular_component
Definition: A membrane coat found on a coated vesicle.
AP-1 adaptor complex (GO:0030121)
Namespace: cellular_component
Definition: A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
Synonyms: AP-1 related adapter complex; HA1; HA1 clathrin adaptor
AP-2 adaptor complex (GO:0030122)
Namespace: cellular_component
Definition: A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
Synonyms: HA2; HA2 clathrin adaptor
AP-3 adaptor complex (GO:0030123)
Namespace: cellular_component
Definition: A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).
AP-4 adaptor complex (GO:0030124)
Namespace: cellular_component
Definition: An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.
clathrin vesicle coat (GO:0030125)
Namespace: cellular_component
Definition: A clathrin coat found on a vesicle.
COPI vesicle coat (GO:0030126)
Namespace: cellular_component
Definition: One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
Synonyms: coatomer
COPII vesicle coat (GO:0030127)
Namespace: cellular_component
Definition: One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
clathrin coat of endocytic vesicle (GO:0030128)
Namespace: cellular_component
Definition: A clathrin coat found on an endocytic vesicle.
Synonyms: clathrin coat of endocytotic vesicle
clathrin coat of synaptic vesicle (GO:0030129)
Namespace: cellular_component
Definition: A clathrin coat found on a synaptic vesicle.
clathrin coat of trans-Golgi network vesicle (GO:0030130)
Namespace: cellular_component
Definition: A clathrin coat found on a vesicle of the trans-Golgi network.
Synonyms: clathrin coat of TGN vesicle
clathrin adaptor complex (GO:0030131)
Namespace: cellular_component
Definition: A membrane coat adaptor complex that links clathrin to a membrane.
clathrin coat of coated pit (GO:0030132)
Namespace: cellular_component
Definition: The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.
transport vesicle (GO:0030133)
Namespace: cellular_component
Definition: Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
Synonyms: constitutive secretory pathway transport vesicle; Golgi to vacuole transport vesicle; Golgi-vacuole transport vesicle; secretory vesicle
Comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
COPII-coated ER to Golgi transport vesicle (GO:0030134)
Namespace: cellular_component
Definition: A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
Synonyms: COPII vesicle; COPII-associated ER to Golgi transport vesicle; COPII-associated vesicle; COPII-coated vesicle; endoplasmic reticulum to Golgi transport vesicle; endoplasmic reticulum-Golgi transport vesicle; ER to Golgi constitutive secretory pathway transport vesicle; ER to Golgi transport vesicle; ER-Golgi transport vesicle
coated vesicle (GO:0030135)
Namespace: cellular_component
Definition: Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
clathrin-coated vesicle (GO:0030136)
Namespace: cellular_component
Definition: A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
COPI-coated vesicle (GO:0030137)
Namespace: cellular_component
Definition: A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
Synonyms: coatomer
endocytic vesicle (GO:0030139)
Namespace: cellular_component
Definition: A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
Synonyms: endocytotic transport vesicle; endocytotic vesicle
trans-Golgi network transport vesicle (GO:0030140)
Namespace: cellular_component
Definition: A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.
Synonyms: TGN transport vesicle; trans-Golgi network constitutive secretory pathway transport vesicle
secretory granule (GO:0030141)
Namespace: cellular_component
Definition: A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
Synonyms: secretory vesicle
Comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
COPI-coated Golgi to ER transport vesicle (GO:0030142)
Namespace: cellular_component
Definition: A vesicle that mediates transport from the Golgi to the endoplasmic reticulum.
Synonyms: Golgi to endoplasmic reticulum transport vesicle; Golgi to ER constitutive secretory pathway transport vesicle; Golgi-endoplasmic reticulum transport vesicle; Golgi-ER transport vesicle; retrograde transport vesicle
COPI-coated inter-Golgi transport vesicle (GO:0030143)
Namespace: cellular_component
Definition: A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack).
Synonyms: inter-Golgi transport constitutive secretory pathway transport vesicle
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity (GO:0030144)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.
Synonyms: alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity; GnTV activity; N-acetylglucosaminyltransferase V activity; UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity; UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity; UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity; uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity; uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity
manganese ion binding (GO:0030145)
Namespace: molecular_function
Definition: Binding to a manganese ion (Mn).
Synonyms: manganese binding; Mn binding
obsolete diuresis (GO:0030146)
Namespace: biological_process
Definition: OBSOLETE. The process of renal water excretion.
Synonyms: diuresis; positive regulation of renal water excretion; renal water excretion
Comment: This term was made obsolete because its definition was inaccurate.
obsolete natriuresis (GO:0030147)
Namespace: biological_process
Definition: OBSOLETE. The process of renal sodium excretion.
Synonyms: natriuresis
Comment: This term was made obsolete because its definition was inaccurate.
sphingolipid biosynthetic process (GO:0030148)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms: sphingolipid anabolism; sphingolipid biosynthesis; sphingolipid formation; sphingolipid synthesis
sphingolipid catabolic process (GO:0030149)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms: sphingolipid breakdown; sphingolipid catabolism; sphingolipid degradation
protein import into mitochondrial matrix (GO:0030150)
Namespace: biological_process
Definition: The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
Synonyms: mitochondrial matrix protein import; mitochondrial translocation; protein transport into mitochondrial matrix
molybdenum ion binding (GO:0030151)
Namespace: molecular_function
Definition: Binding to a molybdenum ion (Mo).
Synonyms: Mo ion binding; molybdenum binding
bacteriocin biosynthetic process (GO:0030152)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.
Synonyms: bacteriocin anabolism; bacteriocin biosynthesis; bacteriocin formation; bacteriocin synthesis
cell differentiation (GO:0030154)
Namespace: biological_process
Definition: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
regulation of cell adhesion (GO:0030155)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
Synonyms: cell adhesion receptor regulator activity
benzodiazepine receptor binding (GO:0030156)
Namespace: molecular_function
Definition: Binding to a peripheral benzodiazepine receptor (PBR).
Synonyms: benzodiazepine receptor ligand; diazepam binding inhibitor activity
pancreatic juice secretion (GO:0030157)
Namespace: biological_process
Definition: The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.
protein xylosyltransferase activity (GO:0030158)
Namespace: molecular_function
Definition: Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.
Synonyms: peptide O-xylosyltransferase activity; UDP-D-xylose:core protein beta-D-xylosyltransferase activity; UDP-D-xylose:core protein xylosyltransferase activity; UDP-D-xylose:protein beta-D-xylosyltransferase activity; UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity; UDP-xylose-core protein beta-D-xylosyltransferase activity; uridine diphosphoxylose-core protein beta-xylosyltransferase activity; uridine diphosphoxylose-protein xylosyltransferase activity
signaling receptor complex adaptor activity (GO:0030159)
Namespace: molecular_function
Definition: The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex.
Synonyms: receptor signaling complex adaptor activity; receptor signaling complex scaffold activity; receptor signaling complex scaffold protein activity; receptor signalling complex adaptor activity; receptor signalling complex scaffold activity
synaptic receptor adaptor activity (GO:0030160)
Namespace: molecular_function
Definition: The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule.
Synonyms: GKAP/Homer scaffold activity; GKAP/Homer scaffold protein; postsynaptic density scaffold protein
obsolete calpain inhibitor activity (GO:0030161)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue.
Synonyms: calpain inhibitor activity
Comment: This term was made obsolete because it represents a regulator of a non-existent molecular function.
regulation of proteolysis (GO:0030162)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
Synonyms: regulation of peptidolysis
protein catabolic process (GO:0030163)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
Synonyms: cellular protein breakdown; cellular protein catabolic process; cellular protein catabolism; cellular protein degradation; multicellular organismal protein catabolic process; pheromone catabolic process; pheromone catabolism; protein breakdown; protein catabolism; protein degradation
Comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
protein denaturation (GO:0030164)
Namespace: biological_process
Definition: Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds.
PDZ domain binding (GO:0030165)
Namespace: molecular_function
Definition: Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
Synonyms: DHR-domain binding; GLGF-domain binding
proteoglycan biosynthetic process (GO:0030166)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
Synonyms: proteoglycan anabolism; proteoglycan biosynthesis; proteoglycan formation; proteoglycan synthesis
proteoglycan catabolic process (GO:0030167)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
Synonyms: proteoglycan breakdown; proteoglycan catabolism; proteoglycan degradation
platelet activation (GO:0030168)
Namespace: biological_process
Definition: A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Synonyms: blood coagulation, platelet activation
low-density lipoprotein particle binding (GO:0030169)
Namespace: molecular_function
Definition: Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
Synonyms: LDL binding
pyridoxal phosphate binding (GO:0030170)
Namespace: molecular_function
Definition: Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
troponin C binding (GO:0030172)
Namespace: molecular_function
Definition: Binding to troponin C, the calcium-binding subunit of the troponin complex.
obsolete integral component of Golgi membrane (GO:0030173)
Namespace: cellular_component
Definition: OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: Golgi integral membrane protein; integral to Golgi membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
regulation of DNA-templated DNA replication initiation (GO:0030174)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
Synonyms: DNA replication licencing; DNA replication licensing; regulation of DNA replication initiation; regulation of DNA-dependent DNA replication initiation
filopodium (GO:0030175)
Namespace: cellular_component
Definition: Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
Comment: A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473.
obsolete integral component of endoplasmic reticulum membrane (GO:0030176)
Namespace: cellular_component
Definition: OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: ER integral membrane protein; integral to endoplasmic reticulum membrane; integral to ER membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
positive regulation of Wnt signaling pathway (GO:0030177)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
Synonyms: activation of frizzled signaling pathway; activation of Wnt receptor signaling pathway; positive regulation of frizzled signaling pathway; positive regulation of frizzled signalling pathway; positive regulation of Wnt receptor signaling pathway; positive regulation of Wnt receptor signalling pathway; positive regulation of Wnt-activated signaling pathway; stimulation of frizzled signaling pathway; stimulation of Wnt receptor signaling pathway; up regulation of frizzled signaling pathway; up regulation of Wnt receptor signaling pathway; up-regulation of frizzled signaling pathway; up-regulation of Wnt receptor signaling pathway; upregulation of frizzled signaling pathway; upregulation of Wnt receptor signaling pathway