LiteFold/GO huggingface dataset:
membrane depolarization during cardiac muscle cell action potential (GO:0086012)
Namespace: biological_process
Definition: The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
membrane repolarization during cardiac muscle cell action potential (GO:0086013)
Namespace: biological_process
Definition: The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
atrial cardiac muscle cell action potential (GO:0086014)
Namespace: biological_process
Definition: An action potential that occurs in an atrial cardiac muscle cell.
SA node cell action potential (GO:0086015)
Namespace: biological_process
Definition: An action potential that occurs in a sinoatrial node cardiac muscle cell.
Synonyms: SA node cardiac muscle cell action potential; SAN cardiac muscle cell action potential; sinoatrial node cardiac muscle cell action potential; sinus node cardiac muscle cell action potential
AV node cell action potential (GO:0086016)
Namespace: biological_process
Definition: An action potential that occurs in an atrioventricular node cardiac muscle cell.
Synonyms: atrioventricular node cardiac muscle cell action potential; AV node cardiac muscle cell action potential
Purkinje myocyte action potential (GO:0086017)
Namespace: biological_process
Definition: An action potential that occurs in a Purkinje myocyte.
SA node cell to atrial cardiac muscle cell signaling (GO:0086018)
Namespace: biological_process
Definition: Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.
Synonyms: SA node cardiac muscle cell to atrial cardiac muscle cell signalling; SA node cardiomyocyte to atrial cardiomyocyte signalling; SAN cardiomyocyte to atrial cardiomyocyte signalling; sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling; sinus node cardiomyocyte to atrial cardiomyocyte signalling
obsolete cell-cell signaling involved in cardiac conduction (GO:0086019)
Namespace: biological_process
Definition: OBSOLETE. Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.
Synonyms: cell-cell signalling involved in cardiac conduction
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling (GO:0086020)
Namespace: molecular_function
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
Synonyms: gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling; gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling; gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling; gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling
SA node cell to atrial cardiac muscle cell communication by electrical coupling (GO:0086021)
Namespace: biological_process
Definition: The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.
Synonyms: SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling; SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling; SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling; sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling; sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling
obsolete SA node cell-atrial cardiac muscle cell adhesion involved in cell communication (GO:0086022)
Namespace: biological_process
Definition: OBSOLETE. The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
Synonyms: SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication; SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication; SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication; sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication; sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate (GO:0086024)
Namespace: biological_process
Definition: OBSOLETE. An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate.
Synonyms: activation of funny current by beta-adrenergic receptor signaling pathway; adenylate cyclase-activating cardiac adrenergic receptor signaling pathway; adrenergic receptor signaling pathway involved in positive regulation of heart rate; adrenergic receptor signalling pathway involved in positive regulation of heart rate; beta adrenergic receptor signaling pathway involved in positive regulation of heart rate; Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate; If activation by beta-adrenergic receptor signaling pathway
Comment: This term was obsoleted because it represents a GO-CAM pathway.
atrial cardiac muscle cell to AV node cell signaling (GO:0086026)
Namespace: biological_process
Definition: Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell.
Synonyms: atrial cardiomyocyte to atrioventricular node cell signaling; atrial cardiomyocyte to AV node cell signaling; atrial cardiomyocyte to AV node cell signalling
AV node cell to bundle of His cell signaling (GO:0086027)
Namespace: biological_process
Definition: Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.
Synonyms: atrioventricular node to bundle of His cell signaling; AV node cell to bundle of His cell signalling
bundle of His cell to Purkinje myocyte signaling (GO:0086028)
Namespace: biological_process
Definition: Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte.
Synonyms: bundle of His cardiac muscle cell to Purkinje myocyte signaling; bundle of His cardiac muscle cell to Purkinje myocyte signalling
Purkinje myocyte to ventricular cardiac muscle cell signaling (GO:0086029)
Namespace: biological_process
Definition: Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.
Synonyms: Purkinje myocyte to ventricular cardiac muscle cell signalling
obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation (GO:0086030)
Namespace: biological_process
Definition: OBSOLETE. An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.
Synonyms: adrenergic receptor signaling pathway involved in cardiac muscle relaxation; adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC; adrenergic receptor-induced cardiac relaxation; Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)
Namespace: biological_process
Definition: OBSOLETE. A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate.
Synonyms: G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate; M2 receptor signalling pathway involved in negative regulation of heart rate; muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate; muscarinic receptor signalling pathway involved in negative regulation of heart rate
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
regulation of cardiac muscle cell membrane potential (GO:0086036)
Namespace: biological_process
Definition: Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential (GO:0086038)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell.
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential (GO:0086039)
Namespace: molecular_function
Definition: A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential.
Synonyms: calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
obsolete sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential (GO:0086040)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential.
Synonyms: sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
voltage-gated potassium channel activity involved in SA node cell action potential depolarization (GO:0086041)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated potassium channel activity involved in SAN cell action potential depolarization; voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization; voltage-gated potassium channel activity involved in sinus node cell action potential depolarization
cardiac muscle cell-cardiac muscle cell adhesion (GO:0086042)
Namespace: biological_process
Definition: The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.
Synonyms: cardiomyocyte-cardiomyocyte adhesion
bundle of His cell action potential (GO:0086043)
Namespace: biological_process
Definition: An action potential that occurs in a bundle of His cell.
Synonyms: bundle of His cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell communication by electrical coupling (GO:0086044)
Namespace: biological_process
Definition: The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.
Synonyms: atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling; atrial cardiomyocyte to AV node cell communication by electrical coupling
membrane depolarization during AV node cell action potential (GO:0086045)
Namespace: biological_process
Definition: The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
Synonyms: membrane depolarization during atrioventricular node cardiac muscle cell action potential; membrane depolarization during AV node cardiac muscle cell action potential
membrane depolarization during SA node cell action potential (GO:0086046)
Namespace: biological_process
Definition: The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
Synonyms: membrane depolarization involved in regulation of SA node cardiac muscle cell action potential; membrane depolarization involved in regulation of SAN cardiac muscle cell action potential; membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential; membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential (GO:0086047)
Namespace: biological_process
Definition: The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
membrane depolarization during bundle of His cell action potential (GO:0086048)
Namespace: biological_process
Definition: The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
Synonyms: membrane depolarization during bundle of His cardiac muscle cell action potential
membrane repolarization during bundle of His cell action potential (GO:0086050)
Namespace: biological_process
Definition: The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
Synonyms: membrane repolarization during bundle of His cardiac muscle cell action potential
membrane repolarization during Purkinje myocyte action potential (GO:0086051)
Namespace: biological_process
Definition: The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
membrane repolarization during SA node cell action potential (GO:0086052)
Namespace: biological_process
Definition: The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
Synonyms: membrane repolarization involved in regulation of SA node cardiac muscle cell action potential; membrane repolarization involved in regulation of SAN cardiac muscle cell action potential; membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential; membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential
AV node cell to bundle of His cell communication by electrical coupling (GO:0086053)
Namespace: biological_process
Definition: The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.
Synonyms: atrioventricular node cell to bundle of His cell communication by electrical coupling
Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling (GO:0086055)
Namespace: biological_process
Definition: The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.
voltage-gated calcium channel activity involved in AV node cell action potential (GO:0086056)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential; voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential
obsolete voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential (GO:0086058)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
voltage-gated calcium channel activity involved SA node cell action potential (GO:0086059)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential; voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential; voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential; voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential
voltage-gated sodium channel activity involved in AV node cell action potential (GO:0086060)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential; voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential
voltage-gated sodium channel activity involved in bundle of His cell action potential (GO:0086061)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential (GO:0086062)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated sodium channel activity involved in SA node cell action potential (GO:0086063)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential; voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential; voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential; voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential
cell communication involved in cardiac conduction (GO:0086065)
Namespace: biological_process
Definition: Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
atrial cardiac muscle cell to AV node cell communication (GO:0086066)
Namespace: biological_process
Definition: The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Synonyms: atrial cardiomyocyte to atrioventricular node cell communication; atrial cardiomyocyte to AV node cell communication