LiteFold/GO huggingface dataset:
establishment of B cell polarity (GO:0001769)
Namespace: biological_process
Definition: The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell.
Synonyms: B cell polarization; B lymphocyte polarization; B-cell polarization; establishment of B lymphocyte polarity; establishment of B-cell polarity; establishment of B-lymphocyte polarity
Comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells.
establishment of natural killer cell polarity (GO:0001770)
Namespace: biological_process
Definition: The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.
Synonyms: establishment of NK cell polarity; natural killer cell polarization; NK cell polarization
immunological synapse formation (GO:0001771)
Namespace: biological_process
Definition: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms: formation of immunological synapse
microglial cell activation (GO:0001774)
Namespace: biological_process
Definition: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
leukocyte homeostasis (GO:0001776)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Synonyms: immune cell homeostasis; leucocyte homeostasis
Comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
T cell homeostatic proliferation (GO:0001777)
Namespace: biological_process
Definition: The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.
Synonyms: resting T cell proliferation; resting T-cell proliferation; T lymphocyte homeostatic proliferation; T-cell homeostatic proliferation; T-lymphocyte homeostatic proliferation
natural killer cell differentiation (GO:0001779)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Synonyms: natural killer cell development; NK cell differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
neutrophil homeostasis (GO:0001780)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.
neutrophil apoptotic process (GO:0001781)
Namespace: biological_process
Definition: Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Synonyms: apoptosis of neutrophils; neutrophil apoptosis; neutrophil programmed cell death by apoptosis; programmed cell death of neutrophils by apoptosis; programmed cell death, neutrophils
B cell homeostasis (GO:0001782)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Synonyms: B lymphocyte homeostasis; B-cell homeostasis; B-lymphocyte homeostasis
Comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
B cell apoptotic process (GO:0001783)
Namespace: biological_process
Definition: Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
Synonyms: apoptosis of B cells; apoptosis of B lymphocytes; apoptosis of B-cells; apoptosis of B-lymphocytes; B cell apoptosis; B cell programmed cell death by apoptosis; B lymphocyte apoptosis; B lymphocyte programmed cell death by apoptosis; B-cell apoptosis; B-cell programmed cell death by apoptosis; B-lymphocyte apoptosis; B-lymphocyte programmed cell death by apoptosis; programmed cell death of B cells by apoptosis; programmed cell death of B lymphocytes by apoptosis; programmed cell death of B-cells by apoptosis; programmed cell death of B-lymphocytes by apoptosis; programmed cell death, B cells; programmed cell death, B lymphocytes; programmed cell death, B-cells; programmed cell death, B-lymphocytes
phosphotyrosine residue binding (GO:0001784)
Namespace: molecular_function
Definition: Binding to a phosphorylated tyrosine residue within a protein.
Synonyms: phosphotyrosine binding
prostaglandin J receptor activity (GO:0001785)
Namespace: molecular_function
Definition: Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.
Synonyms: PGJ receptor activity; PGJ(2) receptor activity
phosphatidylserine binding (GO:0001786)
Namespace: molecular_function
Definition: Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
natural killer cell proliferation (GO:0001787)
Namespace: biological_process
Definition: The expansion of a natural killer cell population by cell division.
Synonyms: NK cell proliferation
antibody-dependent cellular cytotoxicity (GO:0001788)
Namespace: biological_process
Definition: Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
Synonyms: ADCC; antibody dependent cell death; antibody dependent cell killing; antibody-dependent cell death; antibody-dependent cell killing; type VI hypersensitivity
polymeric immunoglobulin binding (GO:0001790)
Namespace: molecular_function
Definition: Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.
IgM binding (GO:0001791)
Namespace: molecular_function
Definition: Binding to an immunoglobulin of the IgM isotype.
polymeric immunoglobulin receptor activity (GO:0001792)
Namespace: molecular_function
Definition: Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
IgM receptor activity (GO:0001793)
Namespace: molecular_function
Definition: Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
type IIa hypersensitivity (GO:0001794)
Namespace: biological_process
Definition: An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell.
Comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity.
type IIb hypersensitivity (GO:0001795)
Namespace: biological_process
Definition: An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.
Synonyms: type V hypersensitivity
Comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity.
negative regulation of type IIa hypersensitivity (GO:0001797)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.
Synonyms: down regulation of type IIa hypersensitivity; down-regulation of type IIa hypersensitivity; downregulation of type IIa hypersensitivity; inhibition of type IIa hypersensitivity
positive regulation of type IIa hypersensitivity (GO:0001798)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.
Synonyms: activation of type IIa hypersensitivity; stimulation of type IIa hypersensitivity; up regulation of type IIa hypersensitivity; up-regulation of type IIa hypersensitivity; upregulation of type IIa hypersensitivity
regulation of type IIb hypersensitivity (GO:0001799)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.
negative regulation of type IIb hypersensitivity (GO:0001800)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.
Synonyms: down regulation of type IIb hypersensitivity; down-regulation of type IIb hypersensitivity; downregulation of type IIb hypersensitivity; inhibition of type IIb hypersensitivity
positive regulation of type IIb hypersensitivity (GO:0001801)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.
Synonyms: activation of type IIb hypersensitivity; stimulation of type IIb hypersensitivity; up regulation of type IIb hypersensitivity; up-regulation of type IIb hypersensitivity; upregulation of type IIb hypersensitivity
type III hypersensitivity (GO:0001802)
Namespace: biological_process
Definition: An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue.
Comment: Note that the Arthus reaction is an example of type III hypersensitivity.
regulation of type III hypersensitivity (GO:0001803)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.
negative regulation of type III hypersensitivity (GO:0001804)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.
Synonyms: down regulation of type III hypersensitivity; down-regulation of type III hypersensitivity; downregulation of type III hypersensitivity; inhibition of type III hypersensitivity
positive regulation of type III hypersensitivity (GO:0001805)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.
Synonyms: activation of type III hypersensitivity; stimulation of type III hypersensitivity; up regulation of type III hypersensitivity; up-regulation of type III hypersensitivity; upregulation of type III hypersensitivity
type IV hypersensitivity (GO:0001806)
Namespace: biological_process
Definition: An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
Synonyms: delayed hypersensitivity response; delayed-type hypersensitivity
regulation of type IV hypersensitivity (GO:0001807)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.
negative regulation of type IV hypersensitivity (GO:0001808)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.
Synonyms: down regulation of type IV hypersensitivity; down-regulation of type IV hypersensitivity; downregulation of type IV hypersensitivity; inhibition of type IV hypersensitivity
positive regulation of type IV hypersensitivity (GO:0001809)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.
Synonyms: activation of type IV hypersensitivity; stimulation of type IV hypersensitivity; up regulation of type IV hypersensitivity; up-regulation of type IV hypersensitivity; upregulation of type IV hypersensitivity
regulation of type I hypersensitivity (GO:0001810)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.
positive regulation of type I hypersensitivity (GO:0001812)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.
Synonyms: activation of type I hypersensitivity; stimulation of type I hypersensitivity; up regulation of type I hypersensitivity; up-regulation of type I hypersensitivity; upregulation of type I hypersensitivity
regulation of antibody-dependent cellular cytotoxicity (GO:0001813)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.
Synonyms: regulation of antibody dependent cell death; regulation of antibody dependent cell killing; regulation of antibody-dependent cell death; regulation of antibody-dependent cell killing
negative regulation of antibody-dependent cellular cytotoxicity (GO:0001814)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.
Synonyms: down regulation of antibody-dependent cellular cytotoxicity; down-regulation of antibody-dependent cellular cytotoxicity; downregulation of antibody-dependent cellular cytotoxicity; inhibition of antibody-dependent cellular cytotoxicity; negative regulation of antibody dependent cell death; negative regulation of antibody dependent cell killing; negative regulation of antibody-dependent cell death; negative regulation of antibody-dependent cell killing
positive regulation of antibody-dependent cellular cytotoxicity (GO:0001815)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.
Synonyms: activation of antibody-dependent cellular cytotoxicity; positive regulation of antibody dependent cell death; positive regulation of antibody dependent cell killing; positive regulation of antibody-dependent cell death; positive regulation of antibody-dependent cell killing; stimulation of antibody-dependent cellular cytotoxicity; up regulation of antibody-dependent cellular cytotoxicity; up-regulation of antibody-dependent cellular cytotoxicity; upregulation of antibody-dependent cellular cytotoxicity
regulation of cytokine production (GO:0001817)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of production of a cytokine.
Synonyms: regulation of cytokine anabolism; regulation of cytokine biosynthesis; regulation of cytokine biosynthetic process; regulation of cytokine formation; regulation of cytokine secretion; regulation of cytokine synthesis
positive regulation of cytokine production (GO:0001819)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of production of a cytokine.
Synonyms: activation of cytokine production; positive regulation of cytokine biosynthetic process; positive regulation of cytokine secretion; stimulation of cytokine production; up regulation of cytokine production; up-regulation of cytokine production; upregulation of cytokine production
serotonin secretion (GO:0001820)
Namespace: biological_process
Definition: The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
Synonyms: 5-HT secretion; 5-hydroxytryptamine secretion; serotonin release
histamine secretion (GO:0001821)
Namespace: biological_process
Definition: The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.
kidney development (GO:0001822)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
Synonyms: nephrogenesis
mesonephros development (GO:0001823)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
Synonyms: Wolffian body development
blastocyst development (GO:0001824)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence.
Synonyms: blastula development
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
blastocyst formation (GO:0001825)
Namespace: biological_process
Definition: The initial formation of a blastocyst from a solid ball of cells known as a morula.
Synonyms: blastula formation
Comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
inner cell mass cell differentiation (GO:0001826)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
inner cell mass cell fate commitment (GO:0001827)
Namespace: biological_process
Definition: The cell fate commitment of precursor cells that will become inner cell mass cells.
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'.
inner cell mass cellular morphogenesis (GO:0001828)
Namespace: biological_process
Definition: The morphogenesis of cells in the inner cell mass.
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
trophectodermal cell differentiation (GO:0001829)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
Synonyms: trophectoderm cell differentiation
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
trophectodermal cell fate commitment (GO:0001830)
Namespace: biological_process
Definition: The cell fate commitment of precursor cells that will become trophectoderm cells.
Synonyms: trophectoderm cell fate commitment
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
trophectodermal cellular morphogenesis (GO:0001831)
Namespace: biological_process
Definition: The morphogenesis of trophectoderm cells.
Synonyms: trophectoderm cellular morphogenesis
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
blastocyst growth (GO:0001832)
Namespace: biological_process
Definition: An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
Synonyms: blastula growth
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
inner cell mass cell proliferation (GO:0001833)
Namespace: biological_process
Definition: The proliferation of cells in the inner cell mass.
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
trophectodermal cell proliferation (GO:0001834)
Namespace: biological_process
Definition: The proliferation of cells in the trophectoderm.
Synonyms: trophectoderm cell proliferation
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
blastocyst hatching (GO:0001835)
Namespace: biological_process
Definition: The hatching of the cellular blastocyst from the zona pellucida.
Synonyms: blastula hatching
Comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'.
release of cytochrome c from mitochondria (GO:0001836)
Namespace: biological_process
Definition: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
Comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.