LiteFold/GO huggingface dataset:
phospholipase activator activity (GO:0016004)
Namespace: molecular_function
Definition: Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.
phospholipase A2 activator activity (GO:0016005)
Namespace: molecular_function
Definition: Binds to and increases the activity of the enzyme phospholipase A2.
Nebenkern (GO:0016006)
Namespace: cellular_component
Definition: A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme.
mitochondrial derivative (GO:0016007)
Namespace: cellular_component
Definition: The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation.
major mitochondrial derivative (GO:0016008)
Namespace: cellular_component
Definition: The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative.
minor mitochondrial derivative (GO:0016009)
Namespace: cellular_component
Definition: The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation.
dystrophin-associated glycoprotein complex (GO:0016010)
Namespace: cellular_component
Definition: A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
Synonyms: DGC; dystrophin glycoprotein complex
dystroglycan complex (GO:0016011)
Namespace: cellular_component
Definition: A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
sarcoglycan complex (GO:0016012)
Namespace: cellular_component
Definition: A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.
Synonyms: sarcoglycan-sarcospan complex
syntrophin complex (GO:0016013)
Namespace: cellular_component
Definition: A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.
Synonyms: nitric oxide synthase-dystrophin complex, skeletal muscle
dystrobrevin complex (GO:0016014)
Namespace: cellular_component
Definition: A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex.
morphogen activity (GO:0016015)
Namespace: molecular_function
Definition: Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.
obsolete short-wave-sensitive opsin (GO:0016016)
Namespace: molecular_function
Definition: OBSOLETE. An opsin with maximal absorption between 400 and 500 nm.
Synonyms: short-wave-sensitive opsin
Comment: This term was made obsolete because it refers to a class of proteins.
cyclosporin A binding (GO:0016018)
Namespace: molecular_function
Definition: Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
Synonyms: cyclophilin
peptidoglycan immune receptor activity (GO:0016019)
Namespace: molecular_function
Definition: Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response.
Synonyms: peptidoglycan receptor activity; peptidoglycan recognition activity
Comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead.
membrane (GO:0016020)
Namespace: cellular_component
Definition: A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
Synonyms: integral component of membrane; integral to membrane; membrane region; region of membrane; transmembrane; whole membrane
CDP-diacylglycerol biosynthetic process (GO:0016024)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
Synonyms: CDP-diacylglycerol anabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol formation; CDP-diacylglycerol synthesis
obsolete proteasome endopeptidase regulator (GO:0016025)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: proteasome endopeptidase regulator
Comment: This term was made obsolete because it does not represent a molecular function.
obsolete proteasome endopeptidase core (GO:0016026)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: proteasome endopeptidase core
Comment: This term was made obsolete because it does not represent a molecular function.
inaD signaling complex (GO:0016027)
Namespace: cellular_component
Definition: A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
Synonyms: inaD signalling complex
rhabdomere (GO:0016028)
Namespace: cellular_component
Definition: The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
subrhabdomeral cisterna (GO:0016029)
Namespace: cellular_component
Definition: A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase.
Synonyms: SMC; submicrovillar cisterna
tRNA import into mitochondrion (GO:0016031)
Namespace: biological_process
Definition: The process in which a tRNA is transported from the cytosol into the mitochondrial matrix.
Synonyms: cytoplasmic tRNA import into mitochondria; cytoplasmic tRNA import into mitochondrion; cytoplasmic tRNA transport into mitochondrion; cytoplasmic tRNA, mitochondrial import; mitochondrial import of cytoplasmic tRNA; nuclear-encoded tRNA import into mitochondrion
viral process (GO:0016032)
Namespace: biological_process
Definition: A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
Synonyms: viral infection; virulence; virus process
Comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'.
maleylacetoacetate isomerase activity (GO:0016034)
Namespace: molecular_function
Definition: Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate.
Synonyms: 4-maleylacetoacetate cis-trans-isomerase activity; maleylacetoacetic isomerase activity; maleylacetone cis-trans-isomerase activity; maleylacetone isomerase activity
zeta DNA polymerase complex (GO:0016035)
Namespace: cellular_component
Definition: A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.
cellular response to phosphate starvation (GO:0016036)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
light absorption (GO:0016037)
Namespace: biological_process
Definition: The reception of a photon by a cell.
Synonyms: absorption of light
absorption of visible light (GO:0016038)
Namespace: biological_process
Definition: The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.
absorption of UV light (GO:0016039)
Namespace: biological_process
Definition: The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm.
glutamate synthase (NADH) activity (GO:0016040)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH.
Synonyms: glutamate (reduced nicotinamide adenine dinucleotide) synthase; GOGAT activity; L-glutamate synthase (NADH); L-glutamate synthase activity; L-glutamate synthetase activity; L-glutamate:NAD+ oxidoreductase (transaminating); NADH-dependent glutamate synthase activity; NADH-glutamate synthase activity; NADH: GOGAT
glutamate synthase (ferredoxin) activity (GO:0016041)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH4+ = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH4+ + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.
Synonyms: ferredoxin-dependent glutamate synthase activity; ferredoxin-glutamate synthase activity; glutamate synthase (ferredoxin-dependent); L-glutamate:ferredoxin oxidoreductase (transaminating)
lipid catabolic process (GO:0016042)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
Synonyms: lipid breakdown; lipid catabolism; lipid degradation; lipolysis; multicellular organism lipid catabolic process; multicellular organismal lipid catabolic process
cellular component organization (GO:0016043)
Namespace: biological_process
Definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
Synonyms: cell organisation; cell organization and biogenesis; cellular component organisation at cellular level; cellular component organisation in other organism; cellular component organization at cellular level; cellular component organization in other organism
detection of bacterium (GO:0016045)
Namespace: biological_process
Definition: The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
Synonyms: detection of bacteria; perception of bacteria; perception of bacterium
detection of fungus (GO:0016046)
Namespace: biological_process
Definition: The series of events in which a stimulus from a fungus is received and converted into a molecular signal.
Synonyms: detection of fungi; detection of parasitic fungi; detection of parasitic fungus; perception of fungi; perception of fungus; perception of parasitic fungi; perception of parasitic fungus
detection of temperature stimulus (GO:0016048)
Namespace: biological_process
Definition: The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal.
Synonyms: detection of temperature; detection of thermal stimulus; perception of temperature
cell growth (GO:0016049)
Namespace: biological_process
Definition: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
Synonyms: cell expansion; cellular growth; growth of cell; metabolic process resulting in cell growth; metabolism resulting in cell growth; non-developmental cell growth; non-developmental growth of a unicellular organism
vesicle organization (GO:0016050)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
Synonyms: vesicle organisation; vesicle organization and biogenesis
carbohydrate biosynthetic process (GO:0016051)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
Synonyms: anabolic carbohydrate metabolic process; anabolic carbohydrate metabolism; carbohydrate anabolism; carbohydrate biosynthesis; carbohydrate formation; carbohydrate synthesis
carbohydrate catabolic process (GO:0016052)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
Synonyms: carbohydrate breakdown; carbohydrate catabolism; carbohydrate degradation; catabolic carbohydrate metabolic process; catabolic carbohydrate metabolism; multicellular organismal carbohydrate catabolic process; single-organism carbohydrate catabolic process
organic acid biosynthetic process (GO:0016053)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
Synonyms: organic acid anabolism; organic acid biosynthesis; organic acid formation; organic acid synthesis
organic acid catabolic process (GO:0016054)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
Synonyms: organic acid breakdown; organic acid catabolism; organic acid degradation
Wnt signaling pathway (GO:0016055)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state.
Synonyms: frizzled signaling pathway; frizzled signalling pathway; Wg signaling pathway; Wg signalling pathway; Wingless signaling pathway; Wingless signalling pathway; Wnt receptor signaling pathway; Wnt receptor signalling pathway; Wnt-activated signaling pathway
G protein-coupled opsin signaling pathway (GO:0016056)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and ending with the light signal being trasmitted through the synapses. The signal can be transmitted via different Galpha subunits types: Go, Gs, Gq, and Gt.
Synonyms: G protein-mediated opsin signaling pathway; rhodopsin mediated phototransduction; rhodopsin mediated signaling pathway; rhodopsin mediated signalling pathway; rhodopsin signaling
regulation of membrane potential in photoreceptor cell (GO:0016057)
Namespace: biological_process
Definition: Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.
Synonyms: changes in polarization state of photoreceptor cell membrane
negative regulation of opsin-mediated signaling pathway (GO:0016059)
Namespace: biological_process
Definition: The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
Synonyms: deactivation of opsin mediated signaling; deactivation of rhodopsin mediated signalling; negative regulation of rhodopsin-mediated signaling pathway; rod response recovery
negative regulation of phospholipase C-activating phototransduction signaling pathway (GO:0016060)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating phototransduction signaling pathway. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it.
Synonyms: metarhodopsin inactivation
obsolete regulation of light-activated channel activity (GO:0016061)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of light-activated channel activity.
Comment: This term was obsoleted because it represents a molecular function.
rhodopsin biosynthetic process (GO:0016063)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas.
Synonyms: rhodopsin anabolism; rhodopsin biosynthesis; rhodopsin formation; rhodopsin synthesis
immunoglobulin mediated immune response (GO:0016064)
Namespace: biological_process
Definition: An immune response mediated by immunoglobulins, whether cell-bound or in solution.
Synonyms: antibody-mediated immune response
type I hypersensitivity (GO:0016068)
Namespace: biological_process
Definition: An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
Synonyms: immediate hypersensitivity response
Comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.
RNA metabolic process (GO:0016070)
Namespace: biological_process
Definition: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
Synonyms: RNA metabolism
mRNA metabolic process (GO:0016071)
Namespace: biological_process
Definition: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
Synonyms: mRNA metabolism
snRNA metabolic process (GO:0016073)
Namespace: biological_process
Definition: The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.
Synonyms: snRNA metabolism
rRNA catabolic process (GO:0016075)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes.
Synonyms: rRNA breakdown; rRNA catabolism; rRNA degradation
snRNA catabolic process (GO:0016076)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.
Synonyms: snRNA breakdown; snRNA catabolism; snRNA degradation
sno(s)RNA catabolic process (GO:0016077)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins.
Synonyms: sno(s)RNA breakdown; sno(s)RNA catabolism; sno(s)RNA degradation; snoRNA catabolic process; sRNA catabolic process
tRNA decay (GO:0016078)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis.
Synonyms: tRNA breakdown; tRNA catabolic process; tRNA catabolism; tRNA degradation
synaptic vesicle exocytosis (GO:0016079)
Namespace: biological_process
Definition: Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
synaptic vesicle targeting (GO:0016080)
Namespace: biological_process
Definition: The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.
synaptic vesicle docking (GO:0016081)
Namespace: biological_process
Definition: The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
Synonyms: synaptic vesicle docking during exocytosis; synaptic vesicle docking involved in exocytosis
Comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015).
synaptic vesicle priming (GO:0016082)
Namespace: biological_process
Definition: A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
Comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)
obsolete synaptic vesicle fusion (GO:0016083)
Namespace: biological_process
Definition: OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane.
Synonyms: synaptic vesicle fusion
Comment: This term was made obsolete because it was wrongly defined.
myoinhibitory hormone activity (GO:0016085)
Namespace: molecular_function
Definition: The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction.
obsolete allatostatin (GO:0016086)
Namespace: molecular_function
Definition: OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone.
Synonyms: allatostatin
Comment: This term was made obsolete because it refers to a gene product.
ecdysiostatic hormone activity (GO:0016087)
Namespace: molecular_function
Definition: The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion.
obsolete insulin (GO:0016088)
Namespace: molecular_function
Definition: OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids.
Synonyms: insulin
Comment: This term was made obsolete because it represents a gene product.
obsolete prenol metabolic process (GO:0016090)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail.
Synonyms: prenol metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.