LiteFold/GO huggingface dataset:
GCN2-mediated signaling (GO:0140469)
Namespace: biological_process
Definition: A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation.
Synonyms: EIF2AK4-mediated signaling; regulation of eIF2 alpha phosphorylation by amino acid starvation
positive regulation of transepithelial migration of symbiont in host (GO:0140471)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host.
Synonyms: positive regulation of symbiont-mediated migration across host transepithelium; positive regulation of symbiont-mediated migration through host transepithelium; positive regulation of transmigration of symbiont in host
cell cortex of non-growing cell tip (GO:0140472)
Namespace: cellular_component
Definition: The region directly beneath the plasma membrane at the cell tip at which no growth takes place.
mitochondrion-endoplasmic reticulum membrane tether activity (GO:0140474)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.
Synonyms: endoplasmic reticulum-mitochondrion membrane adaptor activity; endoplasmic reticulum-mitochondrion membrane tether activity; ER-mitochondrion membrane adaptor activity; ER-mitochondrion membrane tether activity; mitochondrion-endoplasmic reticulum membrane adaptor activity; mitochondrion-ER membrane adaptor activity; mitochondrion-ER membrane tether activity
spindle pole body anchor activity (GO:0140475)
Namespace: molecular_function
Definition: The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way.
ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase (GO:0140479)
Namespace: biological_process
Definition: A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide.
mitotic spindle pole body insertion into the nuclear envelope (GO:0140480)
Namespace: biological_process
Definition: A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane.
Synonyms: establishment of spindle pole body localisation in nuclear envelope; establishment of spindle pole body localization in nuclear envelope; establishment of spindle pole body localization to nuclear envelope
ABC-type iron-sulfur cluster transporter activity (GO:0140481)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out).
Synonyms: ATPase-coupled Fe-S cluster transmembrane transporter activity; ATPase-coupled iron-sulfur cluster transmembrane transporter activity
iron sensor activity (GO:0140482)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron.
kinetochore adaptor activity (GO:0140483)
Namespace: molecular_function
Definition: The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way.
Synonyms: inner kinetochore adaptor activity; outer kinetochore adaptor activity
5-aminolevulinic acid import across plasma membrane (GO:0140484)
Namespace: biological_process
Definition: The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol.
5-aminolevulinic acid transmembrane transporter activity (GO:0140485)
Namespace: molecular_function
Definition: Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other.
zinc ion sequestering activity (GO:0140486)
Namespace: molecular_function
Definition: Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
metal ion sequestering activity (GO:0140487)
Namespace: molecular_function
Definition: Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
heme receptor activity (GO:0140488)
Namespace: molecular_function
Definition: Binding specifically to heme to deliver it to a transport vesicle.
molecular template activity (GO:0140489)
Namespace: molecular_function
Definition: The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence.
microtubule nucleator activity (GO:0140490)
Namespace: molecular_function
Definition: The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly.
Synonyms: microtubule nucleation template activity
metal-dependent deubiquitinase activity (GO:0140492)
Namespace: molecular_function
Definition: An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
Synonyms: metal-dependent ubiquitin-like hydrolase activity; metal-dependent ubiquitinyl-like hydrolase activity
very long-chain fatty acid beta-oxidation (GO:0140493)
Namespace: biological_process
Definition: A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
migrasome (GO:0140494)
Namespace: cellular_component
Definition: A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration.
migracytosis (GO:0140495)
Namespace: biological_process
Definition: A cell migration-dependent mechanism for releasing cellular contents.
gamma-tubulin complex binding (GO:0140496)
Namespace: molecular_function
Definition: Binding to a gamma-tubulin complex.
mannan polymerase II complex (GO:0140497)
Namespace: cellular_component
Definition: A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p.
negative regulation of mitotic spindle assembly checkpoint signaling (GO:0140499)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling.
regulation of reticulophagy (GO:0140500)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of reticulophagy.
Synonyms: regulation of autophagy of the endoplasmic reticulum; regulation of autophagy of the ER; regulation of endoplasmic reticulum autophagy; regulation of endoplasmic reticulum degradation; regulation of ER autophagy; regulation of ER degradation; regulation of ER-phagy
positive regulation of reticulophagy (GO:0140501)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of reticulophagy.
Synonyms: positive regulation of autophagy of the endoplasmic reticulum; positive regulation of autophagy of the ER; positive regulation of endoplasmic reticulum autophagy; positive regulation of endoplasmic reticulum degradation; positive regulation of ER autophagy; positive regulation of ER degradation; positive regulation of ER-phagy
effector-mediated suppression of host salicylic acid-mediated innate immune signaling (GO:0140502)
Namespace: biological_process
Definition: A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signaling.
Synonyms: effector-mediated disruption of host salicylic acid-mediated innate immune signalling; effector-mediated suppression of host salicylic acid-mediated innate immune signalling
microlipophagy (GO:0140504)
Namespace: biological_process
Definition: Degradation of a lipid droplet by microautophagy.
Synonyms: lipid droplet autophagy
regulation of microlipophagy (GO:0140505)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion.
endoplasmic reticulum-autophagosome adaptor activity (GO:0140506)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy.
Synonyms: autophagosome-endoplasmic reticulum anchor; autophagosome-ER anchor; ER- autophagosome anchor
granzyme-mediated programmed cell death signaling pathway (GO:0140507)
Namespace: biological_process
Definition: The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
Synonyms: granzyme-mediated cell death signaling pathway
epithelium-like organization (GO:0140509)
Namespace: biological_process
Definition: The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins.
mitotic nuclear bridge (GO:0140510)
Namespace: cellular_component
Definition: A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei.
Synonyms: nuclear bridge
mitotic nuclear bridge stalk (GO:0140511)
Namespace: cellular_component
Definition: Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes.
mitotic nuclear bridge organization (GO:0140515)
Namespace: biological_process
Definition: A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis.
mitotic nuclear pore complex disassembly (GO:0140516)
Namespace: biological_process
Definition: The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis.
Synonyms: nuclear pore complex disassembly during mitosis
fusogenic activity (GO:0140522)
Namespace: molecular_function
Definition: The activity of joining two lipid bilayers to form a single membrane.
GTPase-dependent fusogenic activity (GO:0140523)
Namespace: molecular_function
Definition: A GTPase activity that mediates the joining of two lipid bilayers to form a single membrane.
Synonyms: membrane fusion GTPase activity
double membrane vesicle viral factory assembly (GO:0140526)
Namespace: biological_process
Definition: A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle.
reciprocal homologous recombination (GO:0140527)
Namespace: biological_process
Definition: A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules.
bilobe structure assembly (GO:0140528)
Namespace: biological_process
Definition: The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone).
Synonyms: bilobe structure biogenesis; bilobe structure formation; kinetoplastid flagellar hook complex assembly
MCM complex loading (GO:0140530)
Namespace: biological_process
Definition: The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly.
Synonyms: MCM complex loading at replication origin; MCM double hexamer formation at replication origin
obsolete regulation of osmosensory signaling MAPK cascade (GO:0140531)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of osmosensory signaling MAPK cascade.
Comment: This term was obsoleted because it represents the same process as regulation of p38MAPK cascade ; GO:1900744.
obsolete negative regulation of osmosensory signaling MAPK cascade (GO:0140532)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling MAPK cascade.
Comment: This term was obsoleted because it represents the same process as negative regulation of p38MAPK cascade ; GO:1903753.
symbiont-mediated suppression of host RNAi-mediated antiviral immune response (GO:0140533)
Namespace: biological_process
Definition: A process by which a symbiont inhibits or disrupts the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: suppression of host RNAi-mediated antiviral immune response; suppression of host RNAi-mediated antiviral immunity; suppression of host RNAi-mediated gene silencing
endoplasmic reticulum protein-containing complex (GO:0140534)
Namespace: cellular_component
Definition: A protein complex that is part of an endoplasmic reticulum.
obsolete nuclear receptor corepressor activity (GO:0140536)
Namespace: molecular_function
Definition: OBSOLETE. A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
Synonyms: nuclear corepressor activity
Comment: The reason for obsoletion is that these activities are not necessarily specific for nuclear receptors subclass of dbTFs, so that distinction leads to misannotations.
transcription regulator activator activity (GO:0140537)
Namespace: molecular_function
Definition: A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification.
Comment: Usage guidance: transcription regulator activators bind to a transcription regulator to allow it to reach the chromatin or to contact other transcriptional regulators. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001216 ; DNA-binding transcription activator activity or GO:0003713; transcription coactivator activity; those activities respectively bind DNA themselves or positively regulate a transcription regulator when it is located at the chromatin.
negative regulation of conjugation with zygote (GO:0140538)
Namespace: biological_process
Definition: A process that prevents a zygote from fusing an additional cell.
regulation of melanotic encapsulation of foreign target (GO:0140539)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of melanotic encapsulation of foreign target.
negative regulation melanotic encapsulation of foreign target (GO:0140540)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of melanotic encapsulation of foreign target.
piRNA transcription (GO:0140541)
Namespace: biological_process
Definition: The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
Synonyms: Piwi-associated RNA transcription; PIWI-interacting RNA transcription
regulation of piRNA transcription (GO:0140542)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the synthesis of a piRNA.
positive regulation of piRNA transcription (GO:0140543)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the synthesis of piRNA.
septin collar organization (GO:0140544)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar.
Synonyms: cellular bud neck septin hourglass organization
ATP-dependent protein disaggregase activity (GO:0140545)
Namespace: molecular_function
Definition: An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates.
Synonyms: protein disaggregase activity; protein unfoldase activity
defense response to symbiont (GO:0140546)
Namespace: biological_process
Definition: Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host.
acquisition of seed longevity (GO:0140547)
Namespace: biological_process
Definition: The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes.
obsolete venom-mediated platelet agglutination (GO:0140548)
Namespace: biological_process
Definition: OBSOLETE. A process in which an organism initiates, promotes, or enhances platelet agglutination in another organism via the action of a venom. This may takes place is via specific proteins binding to cell-surface carbohydrates on the platelet's cell membrane, resulting in calcium-dependent agglutination.
Synonyms: envenomation resulting in blood agglutination in another organism; envenomation resulting in blood agglutination in other organism; venom-mediated blood agglutination
Comment: This term was obsoleted because it represents the same process as venom-mediated platelet aggregation ; GO:0044478.
spore inner membrane (GO:0140549)
Namespace: cellular_component
Definition: The membrane surrounding the spore core (endospore core) that separates it from its external environment.
Synonyms: spore membrane
phosphatidylinositol-4,5-bisphosphate sensor activity (GO:0140550)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate.
Synonyms: phosphatidylinositol-4,5-bisphosphate sensing activity
TEAD-YAP complex (GO:0140552)
Namespace: cellular_component
Definition: A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP.
Synonyms: TEAD-1-YAP complex; TEAD-2 multiprotein complex; TEAD-2-YAP complex; TEAD-3-YAP complex; TEAD-4-YAP complex
xylosyl alpha-1,3-xylosyltransferase activity (GO:0140560)
Namespace: molecular_function
Definition: Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains.
EGF-domain serine glucosyltransferase activity (GO:0140561)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine.
EGF-domain serine xylosyltransferase activity (GO:0140562)
Namespace: molecular_function
Definition: Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine.
UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity (GO:0140563)
Namespace: molecular_function
Definition: Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine.
histone reader activity (GO:0140566)
Namespace: molecular_function
Definition: A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery.
Synonyms: epigenetic reader; histone reader
membrane protein dislocase activity (GO:0140567)
Namespace: molecular_function
Definition: The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis.
Synonyms: transmembrane helix dislocase; transmembrane protein dislocase activity
extraction of mislocalized protein from membrane (GO:0140568)
Namespace: biological_process
Definition: The removal of a mislocalized protein from a cellular membrane.
extraction of mislocalized protein from ER membrane (GO:0140569)
Namespace: biological_process
Definition: The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane.
transmembrane ascorbate ferrireductase activity (GO:0140571)
Namespace: molecular_function
Definition: Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction.
Synonyms: ascorbate-cytochrome b5 reductase activity; L-ascorbate-cytochrome-b5 reductase activity; L-ascorbate:ferricytochrome-b5 oxidoreductase activity
vacuole fission (GO:0140572)
Namespace: biological_process
Definition: The division of a vacuole within a cell to form two or more separate vacuoles.