LiteFold/GO huggingface dataset:
obsolete positive regulation of cGMP catabolic process (GO:0030831)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP.
Synonyms: activation of cGMP catabolic process; positive regulation of cGMP breakdown; positive regulation of cGMP catabolism; positive regulation of cGMP degradation; stimulation of cGMP catabolic process; up regulation of cGMP catabolic process; up-regulation of cGMP catabolic process; upregulation of cGMP catabolic process
Comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism.
regulation of actin filament depolymerization (GO:0030834)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.
Synonyms: regulation of actin depolymerization
negative regulation of actin filament depolymerization (GO:0030835)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
Synonyms: actin filament stabilization; down regulation of actin filament depolymerization; down-regulation of actin filament depolymerization; downregulation of actin filament depolymerization; inhibition of actin filament depolymerization; negative regulation of actin depolymerization; negative regulation of actin polymerization and/or depolymerization
Comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837').
positive regulation of actin filament depolymerization (GO:0030836)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of actin depolymerization.
Synonyms: actin filament destabilization; activation of actin filament depolymerization; positive regulation of actin depolymerization; positive regulation of actin polymerization and/or depolymerization; stimulation of actin filament depolymerization; up regulation of actin filament depolymerization; up-regulation of actin filament depolymerization; upregulation of actin filament depolymerization
Comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838').
negative regulation of actin filament polymerization (GO:0030837)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
Synonyms: down regulation of actin filament polymerization; down-regulation of actin filament polymerization; downregulation of actin filament polymerization; inhibition of actin filament polymerization; negative regulation of actin polymerization; negative regulation of actin polymerization and/or depolymerization
Comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835').
positive regulation of actin filament polymerization (GO:0030838)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of actin polymerization.
Synonyms: activation of actin filament polymerization; positive regulation of actin polymerization; positive regulation of actin polymerization and/or depolymerization; stimulation of actin filament polymerization; up regulation of actin filament polymerization; up-regulation of actin filament polymerization; upregulation of actin filament polymerization
Comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836').
regulation of intermediate filament polymerization (GO:0030839)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament.
negative regulation of intermediate filament polymerization (GO:0030840)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization.
Synonyms: down regulation of intermediate filament polymerization; down-regulation of intermediate filament polymerization; downregulation of intermediate filament polymerization; inhibition of intermediate filament polymerization; negative regulation of intermediate filament polymerization and/or depolymerization
Comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843').
positive regulation of intermediate filament polymerization (GO:0030841)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization.
Synonyms: activation of intermediate filament polymerization; positive regulation of intermediate filament polymerization and/or depolymerization; stimulation of intermediate filament polymerization; up regulation of intermediate filament polymerization; up-regulation of intermediate filament polymerization; upregulation of intermediate filament polymerization
Comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844').
regulation of intermediate filament depolymerization (GO:0030842)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament.
positive regulation of intermediate filament depolymerization (GO:0030844)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization.
Synonyms: activation of intermediate filament depolymerization; positive regulation of intermediate filament polymerization and/or depolymerization; stimulation of intermediate filament depolymerization; up regulation of intermediate filament depolymerization; up-regulation of intermediate filament depolymerization; upregulation of intermediate filament depolymerization
Comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841').
phospholipase C-inhibiting G protein-coupled receptor signaling pathway (GO:0030845)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
Synonyms: G-protein-coupled inhibitory pathway of phospholipase C; GPCR signaling pathway coupled to inhibition of phospholipase C activity; GPCR signaling pathway via inhibition of PLC; inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway; phospholipase C inhibition; phospholipase C-inhibiting G-protein coupled receptor signaling pathway; PLC-inhibiting GPCR signaling pathway
Comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) inhibition.
termination of RNA polymerase II transcription, poly(A)-coupled (GO:0030846)
Namespace: biological_process
Definition: An RNA polymerase II transcription termination process in which cleavage and polyadenylylation of the mRNA 3' end are coupled to transcription termination.
Synonyms: termination of RNA polymerase II transcription, polyadenylation-coupled; transcription termination from Pol II promoter, poly(A) coupled; transcription termination from Pol II promoter, RNA polymerase(A) coupled
termination of RNA polymerase II transcription, exosome-dependent (GO:0030847)
Namespace: biological_process
Definition: The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end.
Synonyms: termination of RNA polymerase II transcription, poly(A)-independent; transcription termination from Pol II promoter, poly(A)-independent; transcription termination from Pol II promoter, RNA polymerase(A)-independent
threo-3-hydroxyaspartate ammonia-lyase activity (GO:0030848)
Namespace: molecular_function
Definition: Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate.
Synonyms: 3-hydroxyaspartate dehydratase activity; L-threo-3-hydroxyaspartate dehydratase activity; threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming); threo-3-hydroxy-L-aspartate ammonia-lyase activity; threo-3-hydroxyaspartate dehydratase activity
autosome (GO:0030849)
Namespace: cellular_component
Definition: Any chromosome other than a sex chromosome.
Comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism.
prostate gland development (GO:0030850)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
Synonyms: prostate development
granulocyte differentiation (GO:0030851)
Namespace: biological_process
Definition: The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
Synonyms: granulocyte cell differentiation
regulation of granulocyte differentiation (GO:0030852)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of granulocyte differentiation.
negative regulation of granulocyte differentiation (GO:0030853)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.
Synonyms: down regulation of granulocyte differentiation; down-regulation of granulocyte differentiation; downregulation of granulocyte differentiation; inhibition of granulocyte differentiation
positive regulation of granulocyte differentiation (GO:0030854)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
Synonyms: activation of granulocyte differentiation; stimulation of granulocyte differentiation; up regulation of granulocyte differentiation; up-regulation of granulocyte differentiation; upregulation of granulocyte differentiation
epithelial cell differentiation (GO:0030855)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
regulation of epithelial cell differentiation (GO:0030856)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of epithelial cell differentiation.
positive regulation of epithelial cell differentiation (GO:0030858)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.
Synonyms: activation of epithelial cell differentiation; stimulation of epithelial cell differentiation; up regulation of epithelial cell differentiation; up-regulation of epithelial cell differentiation; upregulation of epithelial cell differentiation
polarized epithelial cell differentiation (GO:0030859)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis.
regulation of polarized epithelial cell differentiation (GO:0030860)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation.
negative regulation of polarized epithelial cell differentiation (GO:0030861)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation.
Synonyms: down regulation of polarized epithelial cell differentiation; down-regulation of polarized epithelial cell differentiation; downregulation of polarized epithelial cell differentiation; inhibition of polarized epithelial cell differentiation
positive regulation of polarized epithelial cell differentiation (GO:0030862)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of polarized epithelial cell differentiation.
Synonyms: activation of polarized epithelial cell differentiation; stimulation of polarized epithelial cell differentiation; up regulation of polarized epithelial cell differentiation; up-regulation of polarized epithelial cell differentiation; upregulation of polarized epithelial cell differentiation
cortical cytoskeleton (GO:0030863)
Namespace: cellular_component
Definition: The portion of the cytoskeleton that lies just beneath the plasma membrane.
cortical actin cytoskeleton (GO:0030864)
Namespace: cellular_component
Definition: The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cortical cytoskeleton organization (GO:0030865)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
Synonyms: cortical cytoskeleton organisation; cortical cytoskeleton organization and biogenesis
cortical actin cytoskeleton organization (GO:0030866)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
Synonyms: actin cortex stabilization; cortical actin cytoskeleton organisation; cortical actin cytoskeleton organization and biogenesis; cortical actin cytoskeleton stabilization; cortical resistance
rough endoplasmic reticulum membrane (GO:0030867)
Namespace: cellular_component
Definition: The lipid bilayer surrounding the rough endoplasmic reticulum.
Synonyms: RER membrane; rough ER membrane
smooth endoplasmic reticulum membrane (GO:0030868)
Namespace: cellular_component
Definition: The lipid bilayer surrounding the smooth endoplasmic reticulum.
Synonyms: SER membrane; smooth ER membrane
RENT complex (GO:0030869)
Namespace: cellular_component
Definition: A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.
Mre11 complex (GO:0030870)
Namespace: cellular_component
Definition: Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
Synonyms: MRN complex; MRX complex; Rad50 complex; RAD50-MRE11-NBN complex; Rad50-Rad32-Nbs1 complex; RMX complex
nucleolar chromatin (GO:0030874)
Namespace: cellular_component
Definition: The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.
rDNA protrusion (GO:0030875)
Namespace: cellular_component
Definition: Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.
Synonyms: ribosomal DNA protrusion
Comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern.
interleukin-20 receptor complex (GO:0030876)
Namespace: cellular_component
Definition: A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits.
Synonyms: IL-20 receptor complex
beta-catenin destruction complex (GO:0030877)
Namespace: cellular_component
Definition: A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Synonyms: 23S APC complex; APC-Axin-1-beta-catenin complex; Axin-APC-beta-catenin-GSK3B complex; BDC; beta-catenin degradation complex
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
thyroid gland development (GO:0030878)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.
RNA polymerase complex (GO:0030880)
Namespace: cellular_component
Definition: Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.
Synonyms: multisubunit RNA polymerase
beta-2-microglobulin binding (GO:0030881)
Namespace: molecular_function
Definition: Binding to beta-2-microglobulin.
lipid antigen binding (GO:0030882)
Namespace: molecular_function
Definition: Binding to a lipid antigen.
endogenous lipid antigen binding (GO:0030883)
Namespace: molecular_function
Definition: Binding to an endogenous cellular lipid antigen.
exogenous lipid antigen binding (GO:0030884)
Namespace: molecular_function
Definition: Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).
regulation of myeloid dendritic cell activation (GO:0030885)
Namespace: biological_process
Definition: Any process that modulates the frequency or rate of myeloid dendritic cell activation.
negative regulation of myeloid dendritic cell activation (GO:0030886)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.
Synonyms: down regulation of myeloid dendritic cell activation; down-regulation of myeloid dendritic cell activation; downregulation of myeloid dendritic cell activation; inhibition of myeloid dendritic cell activation
positive regulation of myeloid dendritic cell activation (GO:0030887)
Namespace: biological_process
Definition: Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.
Synonyms: activation of myeloid dendritic cell activation; stimulation of myeloid dendritic cell activation; up regulation of myeloid dendritic cell activation; up-regulation of myeloid dendritic cell activation; upregulation of myeloid dendritic cell activation
regulation of B cell proliferation (GO:0030888)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of B cell proliferation.
Synonyms: regulation of B lymphocyte proliferation; regulation of B-cell proliferation; regulation of B-lymphocyte proliferation
negative regulation of B cell proliferation (GO:0030889)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
Synonyms: down regulation of B cell proliferation; down-regulation of B cell proliferation; downregulation of B cell proliferation; inhibition of B cell proliferation; negative regulation of B lymphocyte proliferation; negative regulation of B-cell proliferation; negative regulation of B-lymphocyte proliferation
positive regulation of B cell proliferation (GO:0030890)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of B cell proliferation.
Synonyms: activation of B cell proliferation; positive regulation of B lymphocyte proliferation; positive regulation of B-cell proliferation; positive regulation of B-lymphocyte proliferation; stimulation of B cell proliferation; up regulation of B cell proliferation; up-regulation of B cell proliferation; upregulation of B cell proliferation
VCB complex (GO:0030891)
Namespace: cellular_component
Definition: A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.
Synonyms: pVHL-elongin C-elongin B complex; VHL complex; von Hippel-Lindau tumor suppressor complex
mitotic cohesin complex (GO:0030892)
Namespace: cellular_component
Definition: A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.
Synonyms: nuclear mitotic cohesin complex
meiotic cohesin complex (GO:0030893)
Namespace: cellular_component
Definition: A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
Synonyms: nuclear meiotic cohesin complex
replisome (GO:0030894)
Namespace: cellular_component
Definition: A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
Synonyms: DNA synthesome complex; RC complex; replication-competent complex
apolipoprotein B mRNA editing enzyme complex (GO:0030895)
Namespace: cellular_component
Definition: Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).
Synonyms: apoB mRNA editing enzyme complex; APOBEC
Comment: ASP = APOBEC1 complementation factor 1, a1cf, acf; KSRP = Khsrp (KH-type splicing regulatory protein)
checkpoint clamp complex (GO:0030896)
Namespace: cellular_component
Definition: Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.
Synonyms: CCC; Rad9-Hus1-Rad1 (9-1-1) clamp complex
Comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p.
HOPS complex (GO:0030897)
Namespace: cellular_component
Definition: A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion.
calcium-dependent ATPase activity (GO:0030899)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).