LiteFold/GO huggingface dataset:
pre-B cell differentiation (GO:0002329)
Namespace: biological_process
Definition: The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
Synonyms: pre-B cell development; pre-B lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
pre-B cell receptor expression (GO:0002330)
Namespace: biological_process
Definition: The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell.
pre-B cell allelic exclusion (GO:0002331)
Namespace: biological_process
Definition: Expression of a single heavy chain allele during pre-B cell differentiation.
Synonyms: pre-B lymphocyte allelic exclusion
transitional stage B cell differentiation (GO:0002332)
Namespace: biological_process
Definition: The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.
Synonyms: transitional stage B cell development; transitional stage B lymphocyte differentiation; transitional stage B-cell differentiation; transitional stage B-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
transitional one stage B cell differentiation (GO:0002333)
Namespace: biological_process
Definition: The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.
Synonyms: T1 stage B cell differentiation; transitional one stage B cell development; transitional one stage B lymphocyte differentiation; transitional one stage B-cell differentiation; transitional one stage B-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
transitional two stage B cell differentiation (GO:0002334)
Namespace: biological_process
Definition: The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.
Synonyms: T2 stage B cell differentiation; transitional two stage B cell development; transitional two stage B lymphocyte differentiation; transitional two stage B-cell differentiation; transitional two stage B-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
mature B cell differentiation (GO:0002335)
Namespace: biological_process
Definition: The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
Synonyms: mature B lymphocyte differentiation; mature B-cell differentiation; mature B-lymphocyte differentiation; mature cell development
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
B-1 B cell lineage commitment (GO:0002336)
Namespace: biological_process
Definition: The process in which an immature B cell becomes committed to become a B-1 B cell.
Synonyms: B-1 B lymphocyte lineage commitment; B-1 B-cell lineage commitment; B-1 B-lymphocyte lineage commitment
B-1a B cell differentiation (GO:0002337)
Namespace: biological_process
Definition: The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
Synonyms: B-1a B cell development; B-1a B lymphocyte differentiation; B-1a B-cell differentiation; B-1a B-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
B-1b B cell differentiation (GO:0002338)
Namespace: biological_process
Definition: The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.
Synonyms: B-1b B cell development; B-1b B lymphocyte differentiation; B-1b B-cell differentiation; B-1b B-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
B cell selection (GO:0002339)
Namespace: biological_process
Definition: The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.
Synonyms: B lymphocyte selection; B-cell selection; B-lymphocyte selection
central B cell selection (GO:0002340)
Namespace: biological_process
Definition: Any B cell selection process that occurs in the bone marrow.
Synonyms: central B lymphocyte selection; central B-cell selection; central B-lymphocyte selection
central B cell deletion (GO:0002342)
Namespace: biological_process
Definition: The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.
Synonyms: central B lymphocyte deletion; central B-cell deletion; central B-lymphocyte deletion
peripheral B cell selection (GO:0002343)
Namespace: biological_process
Definition: Any B cell selection process that occurs in the periphery.
Synonyms: peripheral B lymphocyte selection; peripheral B-cell selection; peripheral B-lymphocyte selection
B cell affinity maturation (GO:0002344)
Namespace: biological_process
Definition: The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms: B lymphocyte affinity maturation; B-cell affinity maturation; B-lymphocyte affinity maturation
peripheral B cell receptor editing (GO:0002345)
Namespace: biological_process
Definition: The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.
Synonyms: peripheral B lymphocyte receptor editing; peripheral B-cell receptor editing; peripheral B-lymphocyte receptor editing
histamine production involved in inflammatory response (GO:0002349)
Namespace: biological_process
Definition: The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
Synonyms: histamine production involved in acute inflammatory response
peripheral B cell positive selection (GO:0002350)
Namespace: biological_process
Definition: Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
Synonyms: peripheral B lymphocyte positive selection; peripheral B-cell positive selection; peripheral B-lymphocyte positive selection
serotonin production involved in inflammatory response (GO:0002351)
Namespace: biological_process
Definition: The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
Synonyms: serotonin production involved in acute inflammatory response
B cell negative selection (GO:0002352)
Namespace: biological_process
Definition: Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.
Synonyms: B lymphocyte negative selection; B-cell negative selection; B-lymphocyte negative selection
plasma kallikrein-kinin cascade (GO:0002353)
Namespace: biological_process
Definition: A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
central B cell negative selection (GO:0002354)
Namespace: biological_process
Definition: Any process leading to negative selection of B cells in the bone marrow.
Synonyms: central B lymphocyte negative selection; central B-cell negative selection; central B-lymphocyte negative selection
detection of tumor cell (GO:0002355)
Namespace: biological_process
Definition: The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.
peripheral B cell negative selection (GO:0002356)
Namespace: biological_process
Definition: Any process leading to negative selection of B cells in the periphery.
Synonyms: peripheral B lymphocyte negative selection; peripheral B-cell negative selection; peripheral B-lymphocyte negative selection
defense response to tumor cell (GO:0002357)
Namespace: biological_process
Definition: Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
T cell lineage commitment (GO:0002360)
Namespace: biological_process
Definition: The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
Synonyms: T lymphocyte lineage commitment; T-cell lineage commitment; T-lymphocyte lineage commitment
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (GO:0002361)
Namespace: biological_process
Definition: The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
Synonyms: CD4-positive, CD25-positive, alpha-beta regulatory T cell development; CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation; CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation; CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment (GO:0002362)
Namespace: biological_process
Definition: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
Synonyms: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment; CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment; CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment
alpha-beta T cell lineage commitment (GO:0002363)
Namespace: biological_process
Definition: The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.
Synonyms: alpha-beta T lymphocyte lineage commitment; alpha-beta T-cell lineage commitment; alpha-beta T-lymphocyte lineage commitment
NK T cell lineage commitment (GO:0002364)
Namespace: biological_process
Definition: The process in which a pro-T cell becomes committed to becoming an NK T cell.
Synonyms: natural killer T lymphocyte lineage commitment; natural killer T-cell lineage commitment; natural killer T-lymphocyte lineage commitment; NK T lymphocyte lineage commitment; NK T-cell lineage commitment; NK T-lymphocyte lineage commitment
gamma-delta T cell lineage commitment (GO:0002365)
Namespace: biological_process
Definition: The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell.
Synonyms: gamma-delta T lymphocyte lineage commitment; gamma-delta T-cell lineage commitment; gamma-delta T-lymphocyte lineage commitment
cytokine production involved in immune response (GO:0002367)
Namespace: biological_process
Definition: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
Synonyms: cytokine biosynthetic process involved in immune response; cytokine production during immune response; cytokine secretion during immune response; cytokine secretion involved in immune response
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
B cell cytokine production (GO:0002368)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a B cell.
Synonyms: B lymphocyte cytokine production; B-cell cytokine production; B-lymphocyte cytokine production
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
T cell cytokine production (GO:0002369)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a T cell.
Synonyms: T lymphocyte cytokine production; T-cell cytokine production; T-lymphocyte cytokine production
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
natural killer cell cytokine production (GO:0002370)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a natural killer cell.
Synonyms: NK cell cytokine production
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
myeloid dendritic cell cytokine production (GO:0002372)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a myeloid dendritic cell.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
plasmacytoid dendritic cell cytokine production (GO:0002373)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a plasmacytoid dendritic cell.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
immune system process (GO:0002376)
Namespace: biological_process
Definition: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
Comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
immunoglobulin production (GO:0002377)
Namespace: biological_process
Definition: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: antibody production; immunoglobulin biosynthetic process; immunoglobulin secretion
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
immunoglobulin production involved in immunoglobulin-mediated immune response (GO:0002381)
Namespace: biological_process
Definition: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
Synonyms: antibody production during immune response; antibody secretion during immune response; immunoglobulin biosynthetic process involved in immune response; immunoglobulin production during immune response; immunoglobulin production involved in immune response; immunoglobulin production involved in immunoglobulin mediated immune response; immunoglobulin secretion involved in immune response
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
regulation of tissue kallikrein-kinin cascade (GO:0002382)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
Synonyms: regulation of glandular kallikrein-kinin cascade
immune response in brain or nervous system (GO:0002383)
Namespace: biological_process
Definition: An immune response taking place in the brain or nervous system.
hepatic immune response (GO:0002384)
Namespace: biological_process
Definition: An immune response taking place in the liver.
mucosal immune response (GO:0002385)
Namespace: biological_process
Definition: An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
Synonyms: immune response in MALT; immune response in mucosal-associated lymphoid tissue; immune response in urogenital tract
immune response in gut-associated lymphoid tissue (GO:0002387)
Namespace: biological_process
Definition: Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules.
Synonyms: immune response in GALT
immune response in Peyer's patch (GO:0002388)
Namespace: biological_process
Definition: Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine.
tolerance induction in Peyer's patch (GO:0002389)
Namespace: biological_process
Definition: Tolerance induction taking place in the Peyer's patches.
obsolete platelet activating factor production involved in inflammatory response (GO:0002391)
Namespace: biological_process
Definition: OBSOLETE. The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
Synonyms: platelet activating factor production; platelet activating factor production involved in acute inflammatory response; platelet activating factor secretion; platelet activating factor secretion involved in acute inflammatory response; platelet activating factor secretion involved in inflammatory response
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete lysosomal enzyme production involved in inflammatory response (GO:0002393)
Namespace: biological_process
Definition: OBSOLETE. The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels.
Synonyms: lysosomal enzyme production involved in acute inflammatory response; production of lysosomal enzymes involved in acute inflammatory response; production of lysosomal enzymes involved in inflammatory response
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
tolerance induction in gut-associated lymphoid tissue (GO:0002394)
Namespace: biological_process
Definition: Tolerance induction taking place in the gut-associated lymphoid tissue (GALT).
Synonyms: oral tolerance; tolerance induction in GALT
immune response in nasopharyngeal-associated lymphoid tissue (GO:0002395)
Namespace: biological_process
Definition: An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.
Synonyms: immune response in NALT
MHC protein complex assembly (GO:0002396)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.
MHC class I protein complex assembly (GO:0002397)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules.
MHC class Ib protein complex assembly (GO:0002398)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules.
MHC class II protein complex assembly (GO:0002399)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.
tolerance induction in nasopharyngeal-associated lymphoid tissue (GO:0002400)
Namespace: biological_process
Definition: Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).
Synonyms: nasal tolerance; tolerance induction in NALT
tolerance induction in mucosal-associated lymphoid tissue (GO:0002401)
Namespace: biological_process
Definition: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT).
Synonyms: tolerance induction in MALT
B cell tolerance induction in mucosal-associated lymphoid tissue (GO:0002402)
Namespace: biological_process
Definition: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.
Synonyms: B cell tolerance induction in MALT
T cell tolerance induction in mucosal-associated lymphoid tissue (GO:0002403)
Namespace: biological_process
Definition: Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.
Synonyms: T cell tolerance induction in MALT
antigen sampling in mucosal-associated lymphoid tissue (GO:0002404)
Namespace: biological_process
Definition: The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue.
Synonyms: antigen sampling in MALT; antigen transport in MALT; antigen transport in mucosal-associated lymphoid tissue
antigen sampling by dendritic cells in mucosal-associated lymphoid tissue (GO:0002405)
Namespace: biological_process
Definition: The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.
Synonyms: antigen sampling by dendritic cells in MALT
antigen sampling by M cells in mucosal-associated lymphoid tissue (GO:0002406)
Namespace: biological_process
Definition: The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue.
Synonyms: antigen sampling by M cells in MALT
dendritic cell chemotaxis (GO:0002407)
Namespace: biological_process
Definition: The movement of a dendritic cell in response to an external stimulus.
myeloid dendritic cell chemotaxis (GO:0002408)
Namespace: biological_process
Definition: The movement of a myeloid dendritic cell in response to an external stimulus.
Langerhans cell chemotaxis (GO:0002409)
Namespace: biological_process
Definition: The movement of a Langerhans cell in response to an external stimulus.
plasmacytoid dendritic cell chemotaxis (GO:0002410)
Namespace: biological_process
Definition: The movement of a plasmacytoid dendritic cell in response to an external stimulus.