LiteFold/GO huggingface dataset:
GAIT complex (GO:0097452)
Namespace: cellular_component
Definition: A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
Synonyms: gamma interferon-activated inhibitor of translation complex; IFN-gamma-activated inhibitor of translation complex
mesaxon (GO:0097453)
Namespace: cellular_component
Definition: Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide.
Synonyms: mesaxon of Schwann cell
spiny bracelet of Nageotte (GO:0097455)
Namespace: cellular_component
Definition: Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin.
terminal loop (GO:0097456)
Namespace: cellular_component
Definition: Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath.
Synonyms: terminal loop of Schwann cell
hippocampal mossy fiber (GO:0097457)
Namespace: cellular_component
Definition: An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal.
obsolete neuron part (GO:0097458)
Namespace: cellular_component
Definition: OBSOLETE. Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
Lewy neurite (GO:0097462)
Namespace: cellular_component
Definition: Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease.
gemmule (GO:0097463)
Namespace: cellular_component
Definition: Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex.
thorny excrescence (GO:0097464)
Namespace: cellular_component
Definition: Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads.
somatic spine (GO:0097465)
Namespace: cellular_component
Definition: Spine emanating from the cell soma of a neuron.
ubiquitin-dependent glycoprotein ERAD pathway (GO:0097466)
Namespace: biological_process
Definition: An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
Synonyms: ER-associated glycoprotein degradation; glycoprotein ERAD; gpERAD; misfolded or incompletely synthesized glycoprotein catabolic process
type III terminal bouton (GO:0097467)
Namespace: cellular_component
Definition: Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones.
Synonyms: type III terminal button
programmed cell death in response to reactive oxygen species (GO:0097468)
Namespace: biological_process
Definition: Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
Synonyms: PCD in response to oxidative stress; PCD in response to reactive oxygen species; programmed cell death in response to oxidative stress; reactive oxygen species-mediated PCD; reactive oxygen species-mediated programmed cell death
obsolete cyclin-dependent protein tyrosine kinase activity (GO:0097469)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. This reaction requires the binding of a regulatory cyclin subunit.
Synonyms: cyclin-dependent protein tyrosine kinase activity
Comment: This term was made obsolete because it was added in error; the specific activity it refers to has never been observed.
ribbon synapse (GO:0097470)
Namespace: cellular_component
Definition: Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.
Synonyms: synapsis fasciolaris
cyclin-dependent protein kinase activity (GO:0097472)
Namespace: molecular_function
Definition: Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
Comment: This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
retinal rod cell apoptotic process (GO:0097473)
Namespace: biological_process
Definition: Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.
Synonyms: rod photoreceptor apoptotic process
retinal cone cell apoptotic process (GO:0097474)
Namespace: biological_process
Definition: Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.
Synonyms: cone photoreceptor apoptotic process
motor neuron migration (GO:0097475)
Namespace: biological_process
Definition: The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
spinal cord motor neuron migration (GO:0097476)
Namespace: biological_process
Definition: The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.
lateral motor column neuron migration (GO:0097477)
Namespace: biological_process
Definition: The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme.
synaptic vesicle localization (GO:0097479)
Namespace: biological_process
Definition: Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location.
Synonyms: establishment and maintenance of synaptic vesicle localization; establishment and maintenance of synaptic vesicle position; synaptic vesicle localisation
establishment of synaptic vesicle localization (GO:0097480)
Namespace: biological_process
Definition: The directed movement of a synaptic vesicle or vesicles to a specific location.
Synonyms: establishment of synaptic vesicle localisation
muscle cell postsynaptic specialization (GO:0097482)
Namespace: cellular_component
Definition: A postsynaptic specialization that is part of a neuromuscular junction.
Synonyms: muscle cell postsynaptic density; muscle fiber postsynaptic density
dendrite extension (GO:0097484)
Namespace: biological_process
Definition: Long distance growth of a single dendrite involved in cellular development.
neuron projection guidance (GO:0097485)
Namespace: biological_process
Definition: The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
Synonyms: neurite guidance; neuron process guidance; neuron protrusion guidance; neuronal cell projection guidance
multivesicular body lumen (GO:0097486)
Namespace: cellular_component
Definition: The volume enclosed by the outermost membrane of a multivesicular body.
multivesicular body, internal vesicle (GO:0097487)
Namespace: cellular_component
Definition: A membrane-bounded vesicle wholly contained within a multivesicular body.
multivesicular body, internal vesicle membrane (GO:0097488)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a multivesicular body internal vesicle.
multivesicular body, internal vesicle lumen (GO:0097489)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of the multivesicular body internal vesicle.
sympathetic neuron projection extension (GO:0097490)
Namespace: biological_process
Definition: Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
Synonyms: sympathetic neurite extension; sympathetic neuron process extension; sympathetic neuron protrusion extension; sympathetic neuronal cell projection extension
sympathetic neuron projection guidance (GO:0097491)
Namespace: biological_process
Definition: The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
Synonyms: sympathetic neurite guidance; sympathetic neuron process guidance; sympathetic neuron protrusion guidance; sympathetic neuronal cell projection guidance
sympathetic neuron axon guidance (GO:0097492)
Namespace: biological_process
Definition: The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
Synonyms: sympathetic neuron axon chemotaxis; sympathetic neuron axon growth cone guidance; sympathetic neuron axon pathfinding
structural molecule activity conferring elasticity (GO:0097493)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.
regulation of vesicle size (GO:0097494)
Namespace: biological_process
Definition: Any process that modulates the size of a vesicle.
H-NS-Hha complex (GO:0097495)
Namespace: cellular_component
Definition: A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes.
blood vessel lumen ensheathment (GO:0097496)
Namespace: biological_process
Definition: A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel.
blood vessel endothelial cell delamination (GO:0097497)
Namespace: biological_process
Definition: The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet.
endothelial tube lumen extension (GO:0097498)
Namespace: biological_process
Definition: Any endothelial tube morphogenesis process by which the tube is increased in length.
protein localization to non-motile cilium (GO:0097499)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a location within a non-motile cilium.
Synonyms: protein localization to nonmotile primary cilium
receptor localization to non-motile cilium (GO:0097500)
Namespace: biological_process
Definition: A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium.
Synonyms: receptor localization to nonmotile primary cilium
stress response to metal ion (GO:0097501)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus.
Synonyms: response to excess metal ion; response to metal ion stress; response to metal ion toxicity; response to metal toxicity
obsolete mannosylation (GO:0097502)
Namespace: biological_process
Definition: OBSOLETE. The covalent attachment of a mannose residue to a substrate molecule.
Comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent and represents a molecular function.
sialylation (GO:0097503)
Namespace: biological_process
Definition: The covalent attachment of sialic acid to a substrate molecule.
Gemini of Cajal bodies (GO:0097504)
Namespace: cellular_component
Definition: Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA).
Synonyms: Gemini of coiled bodies; Gems
Rad6-Rad18 complex (GO:0097505)
Namespace: cellular_component
Definition: A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity.
deaminated base DNA N-glycosylase activity (GO:0097506)
Namespace: molecular_function
Definition: DNA N-glycosylase activity acting on deaminated bases.
Synonyms: deaminated base DNA glycosylase activity; DNA glycosylase activity acting on deaminated bases
hypoxanthine DNA N-glycosylase activity (GO:0097507)
Namespace: molecular_function
Definition: DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine).
Synonyms: hypoxanthine-DNA glycosylase activity
xanthine DNA N-glycosylase activity (GO:0097508)
Namespace: molecular_function
Definition: DNA N-glycosylase activity acting on deaminated guanine (xanthine).
Synonyms: xanthine-DNA glycosylase activity
oxanine DNA N-glycosylase activity (GO:0097509)
Namespace: molecular_function
Definition: DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination.
Synonyms: oxanine-DNA glycosylase activity
base-excision repair, AP site formation via deaminated base removal (GO:0097510)
Namespace: biological_process
Definition: A base-excision repair, AP site formation process occurring via excision of a deaminated base.
cardiac myofibril (GO:0097512)
Namespace: cellular_component
Definition: A cardiac myofibril is a myofibril specific to cardiac muscle cells.
myosin II filament (GO:0097513)
Namespace: cellular_component
Definition: A bipolar filament composed of myosin II molecules.
sexual spore wall (GO:0097514)
Namespace: cellular_component
Definition: A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis.
asexual spore wall (GO:0097515)
Namespace: cellular_component
Definition: A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species.
microvillar actin bundle (GO:0097516)
Namespace: cellular_component
Definition: A parallel bundle of actin filaments at the core of a microvillus.
contractile actin filament bundle (GO:0097517)
Namespace: cellular_component
Definition: An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.
parallel actin filament bundle (GO:0097518)
Namespace: cellular_component
Definition: An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.
DNA recombinase complex (GO:0097519)
Namespace: cellular_component
Definition: A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA.
protein-DNA ISRE complex (GO:0097522)
Namespace: cellular_component
Definition: A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA.
transcription ternary complex (GO:0097523)
Namespace: cellular_component
Definition: A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript.
Synonyms: transcription protein-DNA-RNA complex
sperm plasma membrane (GO:0097524)
Namespace: cellular_component
Definition: A plasma membrane that is part of a sperm cell.
spliceosomal snRNP complex (GO:0097525)
Namespace: cellular_component
Definition: A small ribonucleoprotein complex involved in formation of the spliceosome.
spliceosomal tri-snRNP complex (GO:0097526)
Namespace: cellular_component
Definition: A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP.
necroptotic signaling pathway (GO:0097527)
Namespace: biological_process
Definition: The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered.
Synonyms: necroptosis signaling; necroptosis signaling pathway; necroptotic signal transduction; necroptotic signalling pathway
Comment: Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality.
execution phase of necroptosis (GO:0097528)
Namespace: biological_process
Definition: A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died.
Synonyms: execution phase of necroptotic process; necroptosis; necroptotic execution phase
myeloid leukocyte migration (GO:0097529)
Namespace: biological_process
Definition: The movement of a myeloid leukocyte within or between different tissues and organs of the body.
granulocyte migration (GO:0097530)
Namespace: biological_process
Definition: The movement of a granulocyte within or between different tissues and organs of the body.
mast cell migration (GO:0097531)
Namespace: biological_process
Definition: The movement of a mast cell within or between different tissues and organs of the body.
stress response to acid chemical (GO:0097532)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
Synonyms: response to acid stress; stress response to acid
cellular stress response to acid chemical (GO:0097533)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
Synonyms: cellular response to acid stress; cellular stress response to acid
lymphoid lineage cell migration into thymus (GO:0097535)
Namespace: biological_process
Definition: The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process.
Synonyms: lymphoid lineage restricted progenitor cell migration into thymus
thymus epithelium morphogenesis (GO:0097536)
Namespace: biological_process
Definition: The process in which the thymus epithelium is generated and organized.
Synonyms: thymic epithelium morphogenesis
Y-shaped link (GO:0097537)
Namespace: cellular_component
Definition: A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium.
Synonyms: membrane-microtubule complex; Y-link; Y-link structure; Y-shaped assemblage; Y-shaped fiber; Y-shaped fibre; Y-shaped linker
ciliary necklace (GO:0097538)
Namespace: cellular_component
Definition: A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links.
Synonyms: cilial necklace; cilium necklace