LiteFold/GO huggingface dataset:
negative regulation of phialide development (GO:0070806)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.
positive regulation of phialide development (GO:0070807)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.
regulation of Hulle cell development (GO:0070808)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.
negative regulation of Hulle cell development (GO:0070809)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.
positive regulation of Hulle cell development (GO:0070810)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.
glycerol-2-phosphate transmembrane transport (GO:0070811)
Namespace: biological_process
Definition: The process in which glycerol-2-phosphate is transported across a membrane. Glycerol-2-phosphate is a phosphoric monoester of glycerol.
Synonyms: glycerol-2-phosphate transport
hydrogen sulfide metabolic process (GO:0070813)
Namespace: biological_process
Definition: The chemical reactions and pathways involving hydrogen sulfide, H2S.
Synonyms: hydrogen sulfide metabolism; hydrogen sulphide metabolic process; hydrogen sulphide metabolism
hydrogen sulfide biosynthetic process (GO:0070814)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.
Synonyms: hydrogen sulfide anabolism; hydrogen sulfide biosynthesis; hydrogen sulfide formation; hydrogen sulfide synthesis; hydrogen sulphide biosynthesis; hydrogen sulphide biosynthetic process
peptidyl-lysine 5-dioxygenase activity (GO:0070815)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl-[protein] + 2-oxoglutarate + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + succinate + CO2.
Synonyms: lysine hydroxylase activity; lysine,2-oxoglutarate 5-dioxygenase activity; lysine-2-oxoglutarate dioxygenase activity; lysyl hydroxylase activity; peptide-lysine 5-dioxygenase activity; peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity; peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity; protein lysine hydroxylase activity
obsolete phosphorylation of RNA polymerase II C-terminal domain (GO:0070816)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
Synonyms: CTD domain phosphorylation of RNA polymerase II; generation of hyperphosphorylated CTD of RNA polymerase II; generation of II(0) form of RNA polymerase II; hyperphosphorylation of RNA polymerase II C-terminal domain
Comment: This term was obsoleted because it represents a molecular function.
P-TEFb-cap methyltransferase complex localization (GO:0070817)
Namespace: biological_process
Definition: Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location.
Synonyms: establishment and maintenance of P-TEFb-cap methyltransferase complex localization; P-TEFb-cap methyltransferase complex localisation
protoporphyrinogen oxidase activity (GO:0070818)
Namespace: molecular_function
Definition: Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor.
Synonyms: protoporphyrinogen IX oxidase activity; protoporphyrinogen-IX oxidase activity; protoporphyrinogenase activity
menaquinone-dependent protoporphyrinogen oxidase activity (GO:0070819)
Namespace: molecular_function
Definition: Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone.
Synonyms: protoporphyrinogen-IX:menaquinone oxidoreductase activity
tertiary granule (GO:0070820)
Namespace: cellular_component
Definition: A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.
Synonyms: gelatinase granule
Sin3-type complex (GO:0070822)
Namespace: cellular_component
Definition: Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.
HDA1 complex (GO:0070823)
Namespace: cellular_component
Definition: A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.
SHREC complex (GO:0070824)
Namespace: cellular_component
Definition: A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures.
Synonyms: Snf2/HDAC containing repressor complex; Snf2/Hdac repressive complex
chrorion micropyle (GO:0070825)
Namespace: cellular_component
Definition: A single cone-shaped specialization that forms an opening in the egg chorion that allows sperm entry into the egg prior to fertilization.
paraferritin complex (GO:0070826)
Namespace: cellular_component
Definition: A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme.
heterochromatin organization (GO:0070828)
Namespace: biological_process
Definition: Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.
Synonyms: heterochromatin organisation
obsolete heterochromatin maintenance (GO:0070829)
Namespace: biological_process
Definition: OBSOLETE. The chromatin organization process that preserves heterochromatin in a stable functional or structural state.
Synonyms: heterochromatin maintenance involved in chromatin silencing; maintenance of chromatin silencing; maintenance of heterochromatic silencing
Comment: This term was obsoleted because it is redundant with heterochromatin organization and assembly terms.
bicellular tight junction assembly (GO:0070830)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
Synonyms: tight junction formation
basement membrane assembly (GO:0070831)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.
Comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer.
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline (GO:0070832)
Namespace: biological_process
Definition: The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine (GO:0070833)
Namespace: biological_process
Definition: The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine (GO:0070834)
Namespace: biological_process
Definition: The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.
chromium ion transmembrane transporter activity (GO:0070835)
Namespace: molecular_function
Definition: Enables the transfer of chromium (Cr) ions from one side of a membrane to the other.
caveola assembly (GO:0070836)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane.
Synonyms: caveola formation; caveolar biogenesis
dehydroascorbic acid transport (GO:0070837)
Namespace: biological_process
Definition: The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.
Synonyms: dehydroascorbate transport
dynein complex binding (GO:0070840)
Namespace: molecular_function
Definition: Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
Synonyms: dynein binding
inclusion body assembly (GO:0070841)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an inclusion body.
misfolded protein transport (GO:0070843)
Namespace: biological_process
Definition: The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.
polyubiquitinated protein transport (GO:0070844)
Namespace: biological_process
Definition: The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.
Synonyms: polyubiquitylated protein transport
polyubiquitinated misfolded protein transport (GO:0070845)
Namespace: biological_process
Definition: The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.
Synonyms: misfolded polyubiquitinated protein transport; polyubiquitylated misfolded protein transport
Hsp90 deacetylation (GO:0070846)
Namespace: biological_process
Definition: The modification of an Hsp90 protein by removal of acetyl groups.
core mediator complex (GO:0070847)
Namespace: cellular_component
Definition: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Synonyms: C mediator complex; S mediator complex
response to growth factor (GO:0070848)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
Synonyms: response to growth factor stimulus
response to epidermal growth factor (GO:0070849)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
Synonyms: response to EGF stimulus; response to epidermal growth factor stimulus
TACC/TOG complex (GO:0070850)
Namespace: cellular_component
Definition: A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase.
growth factor receptor binding (GO:0070851)
Namespace: molecular_function
Definition: Binding to a growth factor receptor.
cell body fiber (GO:0070852)
Namespace: cellular_component
Definition: A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
Synonyms: cell body fibre; primary neurite
myosin VI binding (GO:0070853)
Namespace: molecular_function
Definition: Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.
myosin VI heavy chain binding (GO:0070854)
Namespace: molecular_function
Definition: Binding to a heavy chain of a myosin VI complex.
myosin VI head/neck binding (GO:0070855)
Namespace: molecular_function
Definition: Binding to the head/neck region of a myosin VI heavy chain.
myosin VI light chain binding (GO:0070856)
Namespace: molecular_function
Definition: Binding to a light chain of a myosin VI complex.
regulation of bile acid biosynthetic process (GO:0070857)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
Synonyms: regulation of bile acid anabolism; regulation of bile acid biosynthesis; regulation of bile acid formation; regulation of bile acid synthesis
negative regulation of bile acid biosynthetic process (GO:0070858)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
Synonyms: down regulation of bile acid biosynthetic process; down-regulation of bile acid biosynthetic process; downregulation of bile acid biosynthetic process; inhibition of bile acid biosynthetic process; negative regulation of bile acid anabolism; negative regulation of bile acid biosynthesis; negative regulation of bile acid formation; negative regulation of bile acid synthesis
positive regulation of bile acid biosynthetic process (GO:0070859)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
Synonyms: activation of bile acid biosynthetic process; positive regulation of bile acid anabolism; positive regulation of bile acid biosynthesis; positive regulation of bile acid formation; positive regulation of bile acid synthesis; stimulation of bile acid biosynthetic process; up regulation of bile acid biosynthetic process; up-regulation of bile acid biosynthetic process; upregulation of bile acid biosynthetic process
RNA polymerase I core factor complex (GO:0070860)
Namespace: cellular_component
Definition: A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
Comment: Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does.
regulation of protein exit from endoplasmic reticulum (GO:0070861)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum.
Synonyms: regulation of protein exit from ER; regulation of protein export from endoplasmic reticulum; regulation of protein export from ER
negative regulation of protein exit from endoplasmic reticulum (GO:0070862)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum.
Synonyms: down regulation of protein exit from endoplasmic reticulum; down-regulation of protein exit from endoplasmic reticulum; downregulation of protein exit from endoplasmic reticulum; inhibition of protein exit from endoplasmic reticulum; negative regulation of protein exit from ER; negative regulation of protein export from endoplasmic reticulum; negative regulation of protein export from ER
positive regulation of protein exit from endoplasmic reticulum (GO:0070863)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum.
Synonyms: activation of protein exit from endoplasmic reticulum; positive regulation of protein exit from ER; positive regulation of protein export from endoplasmic reticulum; positive regulation of protein export from ER; stimulation of protein exit from endoplasmic reticulum; up regulation of protein exit from endoplasmic reticulum; up-regulation of protein exit from endoplasmic reticulum; upregulation of protein exit from endoplasmic reticulum
sperm individualization complex (GO:0070864)
Namespace: cellular_component
Definition: A cellular structure that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst.
investment cone (GO:0070865)
Namespace: cellular_component
Definition: A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization.
Synonyms: F-actin cone
mating projection tip membrane (GO:0070867)
Namespace: cellular_component
Definition: The portion of the plasma membrane surrounding a mating projection tip.
Synonyms: mating projection membrane fusion domain; shmoo tip membrane
obsolete heterochromatin organization involved in chromatin silencing (GO:0070868)
Namespace: biological_process
Definition: OBSOLETE. Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.
Synonyms: heterochromatin organisation involved in chromatin silencing
Comment: This term was obsoleted because it was not clearly defined, and used incorrectly.
obsolete cell wall organization involved in conjugation with cellular fusion (GO:0070871)
Namespace: biological_process
Definition: OBSOLETE. A process of cell wall organization that contributes to conjugation with cellular fusion.
Synonyms: cell wall organisation involved in conjugation with cellular fusion
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
regulation of glycogen metabolic process (GO:0070873)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.
Synonyms: regulation of glycogen metabolism
positive regulation of glycogen metabolic process (GO:0070875)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen.
Synonyms: positive regulation of glycogen metabolism
SOSS complex (GO:0070876)
Namespace: cellular_component
Definition: A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80.
microprocessor complex (GO:0070877)
Namespace: cellular_component
Definition: A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.