LiteFold/GO huggingface dataset:
melatonin receptor activity (GO:0008502)
Namespace: molecular_function
Definition: Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.
benzodiazepine receptor activity (GO:0008503)
Namespace: molecular_function
Definition: Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
monoamine transmembrane transporter activity (GO:0008504)
Namespace: molecular_function
Definition: Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other.
sucrose:proton symporter activity (GO:0008506)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in).
Synonyms: hydrogen/sucrose transporter activity; sucrose:hydrogen symporter activity
sodium:iodide symporter activity (GO:0008507)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).
Synonyms: sodium/iodide symporter activity
bile acid:sodium symporter activity (GO:0008508)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).
Synonyms: sodium/bile acid symporter activity
sodium:bicarbonate symporter activity (GO:0008510)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
Synonyms: sodium/bicarbonate cotransporter activity; sodium:bicarbonate cotransporter activity; sodium:hydrogencarbonate symporter activity
sodium:potassium:chloride symporter activity (GO:0008511)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).
Synonyms: sodium/potassium/chloride symporter activity
sulfate:proton symporter activity (GO:0008512)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in).
Synonyms: sulfate/hydrogen symporter activity; sulfate:hydrogen symporter activity; sulphate:hydrogen symporter activity
obsolete secondary active organic cation transmembrane transporter activity (GO:0008513)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
Synonyms: organic cation porter activity; polyspecific organic cation transmembrane transporter activity
Comment: The reason for obsoletion is that this term was an unnecessary and confusing grouping term.
obsolete organic anion transmembrane transporter activity (GO:0008514)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
Comment: he reason for obsoletion is that this term was an unnecessary and confusing grouping term.
sucrose transmembrane transporter activity (GO:0008515)
Namespace: molecular_function
Definition: Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane.
Synonyms: sucrose permease (PTS) activity; sucrose permease activity
folic acid transmembrane transporter activity (GO:0008517)
Namespace: molecular_function
Definition: Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
Synonyms: folate transmembrane transporter activity; folate transporter activity; folic acid transporter activity; vitamin B9 transporter activity; vitamin M transporter activity
folate:monoatomic anion antiporter activity (GO:0008518)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF.
Synonyms: folate:anion antiporter activity; reduced folate carrier activity; reduced folate transmembrane transporter activity; reduced folate transporter
ammonium channel activity (GO:0008519)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel.
Synonyms: ammonia transmembrane transporter activity; ammonium transmembrane transporter activity
L-ascorbate:sodium symporter activity (GO:0008520)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in).
Synonyms: sodium-dependent L-ascorbate transmembrane transporter activity; sodium-dependent L-ascorbic acid transporter
acetyl-CoA transmembrane transporter activity (GO:0008521)
Namespace: molecular_function
Definition: Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms: acetyl-CoA transporter activity
phosphatidylcholine intramembrane carrier activity (GO:0008525)
Namespace: molecular_function
Definition: Enables the transport of phosphatidylcholine from a region of a membrane to a different region on the same membrane.
Synonyms: phosphatidylcholine intramembrane transporter activity; phosphatidylcholine transmembrane transporter activity; phosphatidylcholine transporter activity
phosphatidylinositol transfer activity (GO:0008526)
Namespace: molecular_function
Definition: Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
Synonyms: intermembrane phosphatidylinositol transfer activity; intermembrane phosphotidylinositol transfer activity; phosphatidylinositol carrier activity; phosphatidylinositol transporter activity
taste receptor activity (GO:0008527)
Namespace: molecular_function
Definition: Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
Synonyms: gustatory receptor
G protein-coupled peptide receptor activity (GO:0008528)
Namespace: molecular_function
Definition: Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G protein coupled peptide receptor activity; G-protein coupled peptide receptor activity; peptide receptor activity, G protein coupled; peptide receptor activity, G-protein coupled
obsolete exogenous peptide receptor activity (GO:0008530)
Namespace: molecular_function
Definition: OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity.
Synonyms: exogenous peptide receptor activity
Comment: This term was made obsolete because it contains both component and function information.
riboflavin kinase activity (GO:0008531)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.
Synonyms: ATP:riboflavin 5'-phosphotransferase activity; FK; flavokinase activity; riboflavin kinase (phosphorylating); riboflavine kinase activity
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity (GO:0008532)
Namespace: molecular_function
Definition: Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H+ + UDP.
Synonyms: galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity; GnTE activity; N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity; poly-N-acetyllactosamine extension enzyme activity; UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity; UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity; UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity; uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase; uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase
obsolete astacin activity (GO:0008533)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.
Synonyms: astacin activity; Astacus proteinase activity; astacus proteinase activity; crayfish small-molecule proteinase activity
Comment: This term was made obsolete because it represents a gene product.
respiratory chain complex IV assembly (GO:0008535)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.
Synonyms: cytochrome c oxidase biogenesis; cytochrome c oxidase complex assembly
proteasome activator complex (GO:0008537)
Namespace: cellular_component
Definition: A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.
Synonyms: PA28
obsolete proteasome activator activity (GO:0008538)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis.
Synonyms: PA28; proteasome activator activity
Comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
obsolete proteasome inhibitor activity (GO:0008539)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis.
Synonyms: PI-31; proteasome inhibitor activity
Comment: The term was made obsolete because 'proteasome' is not a valid molecular function term.
proteasome regulatory particle, base subcomplex (GO:0008540)
Namespace: cellular_component
Definition: The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
visual learning (GO:0008542)
Namespace: biological_process
Definition: Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
Synonyms: spatial learning
fibroblast growth factor receptor signaling pathway (GO:0008543)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
Synonyms: FGF receptor signaling pathway; FGF receptor signalling pathway; FGFR signaling pathway; fibroblast growth factor receptor signalling pathway
epidermis development (GO:0008544)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
Synonyms: hypodermis development
JUN kinase kinase activity (GO:0008545)
Namespace: molecular_function
Definition: Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.
Synonyms: JNKK
obsolete microtubule/chromatin interaction (GO:0008546)
Namespace: biological_process
Definition: OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins.
Synonyms: microtubule/chromatin interaction
Comment: This term was made obsolete because it represents a molecular function.
obsolete protein-synthesizing GTPase activity (GO:0008547)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.
Synonyms: protein-synthesizing GTPase activity
Comment: This term was made obsolete because it represents a gene product.
obsolete signal-recognition-particle GTPase activity (GO:0008548)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis.
Synonyms: signal-recognition-particle GTPase activity
Comment: This term was made obsolete because it represents a gene product.
obsolete dynamin GTPase activity (GO:0008549)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
Synonyms: dynamin GTPase activity; dynamine GTPase activity
Comment: This term was made obsolete because it represents a gene product.
obsolete tubulin GTPase activity (GO:0008550)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.
Synonyms: tubulin GTPase activity
Comment: This term was made obsolete because it represents a gene product.
P-type cadmium transporter activity (GO:0008551)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out).
Synonyms: cadmium exporting ATPase activity; cadmium transmembrane transporter activity, phosphorylative mechanism; cadmium-exporting ATPase activity; cadmium-translocating P-type ATPase activity; Cd(2+)-exporting ATPase activity; Cd2+-exporting ATPase activity
obsolete zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity (GO:0008552)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+.
Synonyms: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
Comment: This term was made obsolete because it represents more than one molecular function.
P-type proton-exporting transporter activity (GO:0008553)
Namespace: molecular_function
Definition: Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
Synonyms: H+-exporting ATPase activity; H+-transporting ATPase; H+-transporting ATPase activity; hydrogen exporting ATPase activity, phosphorylative mechanism; hydrogen-/sodium-translocating ATPase activity; hydrogen-exporting ATPase activity; hydrogen-exporting ATPase activity, phosphorylative mechanism; P-type H+-exporting ATPase activity; proton transport ATPase activity; proton-exporting ATPase activity; proton-exporting ATPase activity, phosphorylative mechanism; proton-translocating ATPase activity; proton-transporting ATPase activity
P-type sodium transporter activity (GO:0008554)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism.
Synonyms: Na(+)-exporting ATPase activity; Na(+)-transporting ATPase activity; Na+-exporting ATPase activity; Na+-transporting ATPase activity; sodium exporting ATPase activity, phosphorylative mechanism; sodium transmembrane transporter activity, phosphorylative mechanism; sodium transport ATPase activity; sodium-exporting ATPase activity; sodium-exporting ATPase activity, phosphorylative mechanism; sodium-translocating P-type ATPase activity
Comment: Note that RHEA:14633 represents both the ABC and the P-type sodium transporters.
P-type potassium transmembrane transporter activity (GO:0008556)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).
Synonyms: ATP phosphohydrolase (K+-importing); ATP-dependent potassium transmembrane transporter activity; ATPase-coupled potassium transmembrane transporter activity; K(+)-importing ATPase activity; K(+)-transporting ATPase activity; K+-importing ATPase activity; K+-transporting ATPase activity; potassium ABC transporter; potassium transmembrane transporter activity, phosphorylative mechanism; potassium transporting ATPase activity; potassium-importing ATPase activity; potassium-transporting ATPase activity; potassium-uptake-ATPase activity
ABC-type guanine transporter activity (GO:0008558)
Namespace: molecular_function
Definition: Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in).
Synonyms: ATP-dependent guanine transmembrane transporter activity; ATPase-coupled guanine transmembrane transporter activity; guanine ABC transporter; guanine-transporting ATPase activity
ABC-type xenobiotic transporter activity (GO:0008559)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
Synonyms: ATP phosphohydrolase (xenobiotic-exporting); ATP-dependent xenobiotic transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; MDR protein; multidrug resistance exporter; multidrug-resistance protein; P-glycoprotein; PDR protein; pleiotropic-drug-resistance protein; xenobiotic ABC transporter; xenobiotic transmembrane transporting ATPase activity
obsolete alpha-factor sex pheromone exporter (GO:0008563)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process.
Synonyms: alpha-factor sex pheromone exporter; alpha-factor-transporting ATPase
Comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported.
protein-exporting ATPase activity (GO:0008564)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) = ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.
Synonyms: ATPase-coupled protein transporter activity
Comment: Represents ATP- hydrolyzing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eukaryotes, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex.
obsolete protein transporter activity (GO:0008565)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of proteins into, out of or within a cell, or between cells.
Synonyms: enzyme transporter activity; holin; protein transport chaperone; secretin
Comment: This term was obsoleted because is has been inconsistently used.
mitochondrial protein-transporting ATPase activity (GO:0008566)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.
Synonyms: ATPase-coupled mitochondrial protein transporter activity
Comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'.
microtubule severing ATPase activity (GO:0008568)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.
Synonyms: ATP phosphohydrolase (tubulin-dimerizing); katanin activity; microtubule-severing ATPase activity
Comment: See also the cellular component term 'katanin complex ; GO:0008352'.