LiteFold/GO huggingface dataset:
obsolete TNFSF11 receptor activity (GO:0038058)
Namespace: molecular_function
Definition: OBSOLETE. Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function.
Synonyms: RANKL receptor activity; tumor necrosis factor ligand superfamily member 11 receptor activity
Comment: This term aws obsoleted because it represents a gene product.
IKKalpha-IKKalpha complex (GO:0038059)
Namespace: cellular_component
Definition: A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits.
Synonyms: IkappaB kinase alpha homodimer; IkappaB kinase-alpha homodimer; IKKalpha homodimer; IKKalpha homodimeric complex; IKKalpha-IKKalpha protein complex
nitric oxide-cGMP-mediated signaling (GO:0038060)
Namespace: biological_process
Definition: An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.
Synonyms: canonical nitric oxide signaling; classical nitric oxide signaling; nitric oxide-cGMP-mediated signal transduction; nitric oxide-cGMP-mediated signaling pathway; nitric oxide-cGMP-mediated signalling pathway; NO-cGMP signaling pathway
protein tyrosine kinase collagen receptor activity (GO:0038062)
Namespace: molecular_function
Definition: Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
Synonyms: collagen RTK activity; discoidin domain receptor
collagen-activated tyrosine kinase receptor signaling pathway (GO:0038063)
Namespace: biological_process
Definition: The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: collagen-activated RTK signaling pathway; collagen-activated tyrosine kinase receptor signalling pathway; DDR signaling pathway; discoidin domain receptor signaling pathway
collagen receptor activity (GO:0038064)
Namespace: molecular_function
Definition: Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: transmembrane collagen receptor activity
p38MAPK cascade (GO:0038066)
Namespace: biological_process
Definition: A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Synonyms: MAPK14 cascade; osmosensory signaling MAPK cascade; p38 cascade; p38 MAPK cascade
obsolete MAP kinase activity involved in cell wall organization or biogenesis (GO:0038067)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis.
Synonyms: MAP kinase activity involved in cell wall biogenesis; MAP kinase activity involved in cell wall integrity; MAPK activity involved in cell wall biogenesis
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase kinase activity involved in cell wall organization or biogenesis (GO:0038068)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis.
Synonyms: MAP kinase kinase activity involved in cell wall biogenesis; MAP2K activity involved in cell wall integrity; MAPKK activity involved in cell wall integrity
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase phosphatase activity involved in regulation of cell wall biogenesis (GO:0038069)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis.
Synonyms: Mpk1 phosphatase activity; Slt2 phosphatase activity
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase kinase kinase activity involved in cell wall organization or biogenesis (GO:0038070)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis.
Synonyms: MAP kinase kinase kinase activity involved in cell wall biogenesis; MAP3K activity involved in cell wall integrity; MAPKKK activity involved in cell wall integrity
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase activity involved in conjugation with cellular fusion (GO:0038071)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion.
Synonyms: MAPK activity involved in conjugation with cellular fusion
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase kinase activity involved in conjugation with cellular fusion (GO:0038072)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion.
Synonyms: MAP2K activity involved in conjugation with cellular fusion; MAPKK activity involved in conjugation with cellular fusion
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase kinase kinase activity involved in conjugation with cellular fusion (GO:0038073)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis.
Synonyms: MAP3K activity involved in conjugation with cellular fusion; MAPKKK activity involved in conjugation with cellular fusion
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion (GO:0038074)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion.
Synonyms: MAPK phosphatase activity involved in regulation of conjugation with cellular fusion
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase activity involved in innate immune response (GO:0038075)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response.
Synonyms: MAPK activity involved in innate immune response
Comment: This term was obsoleted because it should be represented as a GO-CAM model.
obsolete MAP kinase kinase activity involved in innate immune response (GO:0038076)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response.
Synonyms: MAP2K activity involved in innate immune response; MAPKK activity involved in innate immune response
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase kinase kinase activity involved in innate immune response (GO:0038077)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response.
Synonyms: MAP3K activity involved in innate immune response; MAPKKK activity involved in innate immune response
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase activity involved in osmosensory signaling pathway (GO:0038079)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.
Synonyms: MAP kinase activity involved in osmosensory signalling pathway; MAPK activity involved in osmosensory signaling pathway
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase kinase activity involved in osmosensory signaling pathway (GO:0038080)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.
Synonyms: MAP kinase kinase activity involved in osmosensory signalling pathway; MAP2K activity involved in osmosensory signaling pathway; MAPKK activity involved in osmosensory signaling pathway
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase kinase kinase activity involved in osmosensory signaling pathway (GO:0038081)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.
Synonyms: MAP kinase kinase kinase activity involved in osmosensory signalling pathway; MAP3K activity involved in osmosensory signaling pathway; MAPKKK activity involved in osmosensory signaling pathway
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
obsolete MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway (GO:0038082)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.
Synonyms: Hog1 phosphatase activity; MAP kinase phosphatase activity involved in regulation of osmosensory signalling pathway; MAPK phosphatase activity involved in regulation of osmosensory signaling pathway
Comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term.
peptidyl-tyrosine autophosphorylation (GO:0038083)
Namespace: biological_process
Definition: The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.
Synonyms: receptor tyrosine kinase autophosphorylation; RTK autophosphorylation; tyrosine autophosphorylation
vascular endothelial growth factor signaling pathway (GO:0038084)
Namespace: biological_process
Definition: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: vascular endothelial growth factor signalling pathway; VEGF signaling; VEGF-activated signaling pathway
Comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
VEGF-activated platelet-derived growth factor receptor signaling pathway (GO:0038086)
Namespace: biological_process
Definition: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway; VEGF-A/PDGFR signaling; VEGF-activated PDGFR signalling pathway; VEGF-activated platelet-derived growth factor receptor signalling pathway; VEGF/PDGFR signaling pathway
VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway (GO:0038087)
Namespace: biological_process
Definition: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway; VEGF-A/PDGFRalpha signaling; VEGF-activated PDGFRalpha signalling pathway; VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway; VEGF/PDGFRalpha signaling pathway
positive regulation of cell migration by vascular endothelial growth factor signaling pathway (GO:0038089)
Namespace: biological_process
Definition: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.
Synonyms: positive regulation of cell migration by vascular endothelial growth factor signalling pathway; positive regulation of cell migration by VEGF signaling pathway; VEGF-A-induced cell migration; VEGF-induced cell migration
positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway (GO:0038090)
Namespace: biological_process
Definition: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.
Synonyms: positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway; positive regulation of cell migration by VEGF/PDGFR signaling pathway; VEGF/PDGFR-induced cell migration
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway (GO:0038091)
Namespace: biological_process
Definition: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.
Synonyms: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway; positive regulation of cell proliferation by VEGF/PDGFR signaling pathway; VEGF-A-induced cell proliferation
Fc receptor signaling pathway (GO:0038093)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Synonyms: Fc receptor signalling pathway
Fc-gamma receptor signaling pathway (GO:0038094)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Synonyms: Fc-gamma receptor signalling pathway
Fc-epsilon receptor signaling pathway (GO:0038095)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Synonyms: Fc-epsilon receptor signalling pathway
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway (GO:0038097)
Namespace: biological_process
Definition: An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.
Synonyms: Fc epsilon RI-dependent mast cell activation; Fc epsilon RI-mediated mast cell activation; positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway
obsolete sequestering of BMP from receptor via BMP binding (GO:0038098)
Namespace: biological_process
Definition: OBSOLETE. Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.
Synonyms: extracellular sequestering of BMP; extracellular sequestering of bone morphogenetic protein
Comment: The reason for obsoletion is that this term represents a molecular function and not a real GO process.
nodal receptor complex assembly (GO:0038099)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals).
Synonyms: ActRIIB.ALK4.EGF-CFC complex formation; nodal receptor complex formation
obsolete sequestering of nodal from receptor via nodal binding (GO:0038101)
Namespace: biological_process
Definition: OBSOLETE. Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor.
Synonyms: binding to and sequestering nodal; extracellular regulation of nodal; nodal antagonist activity
Comment: The reason for obsoletion is that this term represents a molecular function and not a real GO process.
activin receptor antagonist activity (GO:0038102)
Namespace: molecular_function
Definition: Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.
Comment: This term refers to inhibition of a member of the activin receptor family; activin receptors bind to multiple ligands including activin and nodal.
obsolete activin receptor antagonist activity involved in negative regulation of nodal signaling pathway (GO:0038103)
Namespace: molecular_function
Definition: OBSOLETE. Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.
Synonyms: activin receptor antagonist activity involved in negative regulation of nodal signalling pathway; nodal antagonist activity
Comment: This term was obsoleted because it represents a GO-CAM model.
choriogonadotropin hormone binding (GO:0038106)
Namespace: molecular_function
Definition: Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit.
Synonyms: chorionic gonadotrophin binding; chorionic gonadotropin binding
obsolete nodal signaling pathway involved in determination of left/right asymmetry (GO:0038107)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by a nodal protein binding of to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves.
Synonyms: nodal signalling pathway involved in determination of left/right asymmetry; regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry
Comment: This term was obsoleted because it represents a GO-CAM model.
negative regulation of appetite by leptin-mediated signaling pathway (GO:0038108)
Namespace: biological_process
Definition: The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.
Synonyms: inhibition of appetite by leptin signaling; negative regulation of appetite by leptin-mediated signalling pathway; reduction of appetite by leptin-mediated signaling; suppression of appetite by leptin-mediated signaling pathway
interleukin-2-mediated signaling pathway (GO:0038110)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-2-mediated signaling pathway; interleukin-2-mediated signalling pathway
interleukin-7-mediated signaling pathway (GO:0038111)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-7-mediated signaling pathway; interleukin-7-mediated signalling pathway
interleukin-8-mediated signaling pathway (GO:0038112)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-8 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-8-mediated signaling pathway; interleukin-8-mediated signalling pathway