LiteFold/GO huggingface dataset:
obsolete histone H3-K27 methylation (GO:0070734)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone.
Synonyms: histone H3 K27 methylation; histone H3K27me; histone lysine H3 K27 methylation
Comment: This term was obsoleted because it represents a molecular function.
protein-glycine ligase activity (GO:0070735)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate.
Synonyms: protein glycylase activity
protein-glycine ligase activity, initiating (GO:0070736)
Namespace: molecular_function
Definition: Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein.
Synonyms: protein glycylase activity, initiating
protein-glycine ligase activity, elongating (GO:0070737)
Namespace: molecular_function
Definition: Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain.
Synonyms: protein glycylase activity, elongating
tubulin-glycine ligase activity (GO:0070738)
Namespace: molecular_function
Definition: Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin.
Synonyms: tubulin glycylase activity
protein-glutamic acid ligase activity (GO:0070739)
Namespace: molecular_function
Definition: Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein.
Synonyms: protein glutamylase activity; protein-glutamate ligase activity
tubulin-glutamic acid ligase activity (GO:0070740)
Namespace: molecular_function
Definition: Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.
Synonyms: tubulin glutamylase activity; tubulin-glutamate ligase activity
response to interleukin-6 (GO:0070741)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
Synonyms: response to IL-6
C2H2 zinc finger domain binding (GO:0070742)
Namespace: molecular_function
Definition: Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.
interleukin-23 complex (GO:0070743)
Namespace: cellular_component
Definition: A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
Synonyms: IL-23 complex; IL12B; IL23A; p19; p40
Comment: Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.
interleukin-35 complex (GO:0070745)
Namespace: cellular_component
Definition: A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space.
Synonyms: EBI3; IL-35 complex; IL12A; p35
Comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene.
interleukin-35 binding (GO:0070746)
Namespace: molecular_function
Definition: Binding to interleukin-35.
Synonyms: IL-35 binding
interleukin-35 receptor activity (GO:0070747)
Namespace: molecular_function
Definition: Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-35 receptor activity; IL-35R
interleukin-35 receptor binding (GO:0070748)
Namespace: molecular_function
Definition: Binding to an interleukin-35 receptor.
Synonyms: IL-35; interleukin-35 receptor ligand
interleukin-35 production (GO:0070753)
Namespace: biological_process
Definition: The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: IL-35 production; interleukin-35 biosynthetic process; interleukin-35 secretion
regulation of interleukin-35 production (GO:0070754)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of interleukin-35 production.
Synonyms: regulation of IL-35 production; regulation of interleukin-35 biosynthetic process
negative regulation of interleukin-35 production (GO:0070755)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production.
Synonyms: down regulation of interleukin-35 production; down-regulation of interleukin-35 production; downregulation of interleukin-35 production; inhibition of interleukin-35 production; negative regulation of IL-35 production; negative regulation of interleukin-35 biosynthetic process
positive regulation of interleukin-35 production (GO:0070756)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, or extent of interleukin-35 production.
Synonyms: activation of interleukin-35 production; positive regulation of IL-35 production; positive regulation of interleukin-35 biosynthetic process; stimulation of interleukin-35 production; up regulation of interleukin-35 production; up-regulation of interleukin-35 production; upregulation of interleukin-35 production
interleukin-35-mediated signaling pathway (GO:0070757)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-35 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-35-mediated signaling pathway; interleukin-35-mediated signalling pathway
regulation of interleukin-35-mediated signaling pathway (GO:0070758)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of an interleukin-35-mediated signaling pathway.
Synonyms: regulation of IL-35-mediated signaling pathway; regulation of interleukin-35-mediated signalling pathway
negative regulation of interleukin-35-mediated signaling pathway (GO:0070759)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of an interleukin-35-mediated signaling pathway.
Synonyms: negative regulation of IL-35-mediated signaling pathway; negative regulation of interleukin-35-mediated signalling pathway
positive regulation of interleukin-35-mediated signaling pathway (GO:0070760)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of an interleukin-35-mediated signaling pathway.
Synonyms: positive regulation of IL-35-mediated signaling pathway; positive regulation of interleukin-35-mediated signalling pathway
pre-snoRNP complex (GO:0070761)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.
Synonyms: pre-small nucleolar ribonucleoprotein complex
nuclear pore transmembrane ring (GO:0070762)
Namespace: cellular_component
Definition: A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.
Synonyms: NDC1 complex; NDC1 subcomplex
Delta1 complex (GO:0070763)
Namespace: cellular_component
Definition: A protein complex that consists of homodimer of the Notch ligand Delta1.
Synonyms: Delta1 homodimer complex
gamma-secretase-Delta1 complex (GO:0070764)
Namespace: cellular_component
Definition: A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.
gamma-secretase complex (GO:0070765)
Namespace: cellular_component
Definition: A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
Synonyms: CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant); gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant); gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN); gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN); gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN); presenilin complex; PS1 complex; PS2 complex
endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex (GO:0070766)
Namespace: cellular_component
Definition: A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof).
Synonyms: SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2); Stx4-Napa-Vamp3-Nsf-Vamp2 complex
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex (GO:0070768)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof).
Synonyms: Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex; SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)
alphaIIb-beta3 integrin-CIB complex (GO:0070769)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.
Synonyms: ITGA2B-ITGB3-CIB1 complex
alphaIIb-beta3 integrin-CD47-FAK complex (GO:0070770)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.
Synonyms: ITGA2b-ITGB3-CD47-FAK complex
alphaIIb-beta3 integrin-CD47-Src complex (GO:0070771)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.
Synonyms: ITGA2b-ITGB3-CD47-SRC complex
PAS complex (GO:0070772)
Namespace: cellular_component
Definition: A phosphatidylinositol kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKFYVE in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Synonyms: autophagy-specific phosphatidylinositol 3-kinase complex
protein-N-terminal glutamine amidohydrolase activity (GO:0070773)
Namespace: molecular_function
Definition: Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal glutamine residue of a protein.
Synonyms: NtQ-amidase activity
obsolete phytoceramidase activity (GO:0070774)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine.
Comment: The reason for obsoletion is that this term represents a specific substrate of GO:0017040 N-acylsphingosine amidohydrolase activity.
H3 histone acetyltransferase complex (GO:0070775)
Namespace: cellular_component
Definition: A multisubunit complex that catalyzes the acetylation of histone H3.
Synonyms: H3 HAT complex
MOZ/MORF histone acetyltransferase complex (GO:0070776)
Namespace: cellular_component
Definition: A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
D-aspartate transmembrane transport (GO:0070777)
Namespace: biological_process
Definition: The process in which D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid  is transported across a lipid bilayer, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
L-aspartate transmembrane transport (GO:0070778)
Namespace: biological_process
Definition: The directed movement of L-aspartate across a membrane by means of some agent such as a transporter or a pore.
Synonyms: L-aspartate transport
D-aspartate import across plasma membrane (GO:0070779)
Namespace: biological_process
Definition: The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
Synonyms: D-aspartate import; D-aspartate import into cell; D-aspartate uptake
response to biotin (GO:0070781)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus.
Synonyms: response to Bios IIB; response to coenzyme R; response to vitamin B7; response to vitamin H
phosphatidylserine exposure on apoptotic cell surface (GO:0070782)
Namespace: biological_process
Definition: A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
Synonyms: externalization of phosphatidylserine
Comment: In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure.
growth of unicellular organism as a thread of attached cells (GO:0070783)
Namespace: biological_process
Definition: A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions.
regulation of growth of unicellular organism as a thread of attached cells (GO:0070784)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.
negative regulation of growth of unicellular organism as a thread of attached cells (GO:0070785)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.
positive regulation of growth of unicellular organism as a thread of attached cells (GO:0070786)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.
conidiophore development (GO:0070787)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.
conidiophore stalk development (GO:0070788)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.
metula development (GO:0070789)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.
Synonyms: development of primary sterigmata
phialide development (GO:0070790)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips.
Synonyms: development of secondary sterigmata
Hulle cell development (GO:0070792)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.
Synonyms: Huelle cell development; Hulle cell formation
regulation of conidiophore development (GO:0070793)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.
negative regulation of conidiophore development (GO:0070794)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.
positive regulation of conidiophore development (GO:0070795)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.
negative regulation of cleistothecium development (GO:0070797)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.
positive regulation of cleistothecium development (GO:0070798)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.
regulation of conidiophore stalk development (GO:0070799)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.
negative regulation of conidiophore stalk development (GO:0070800)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.
positive regulation of conidiophore stalk development (GO:0070801)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.
regulation of metula development (GO:0070802)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.
negative regulation of metula development (GO:0070803)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.
positive regulation of metula development (GO:0070804)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.
regulation of phialide development (GO:0070805)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.