LiteFold/GO huggingface dataset:
T cell tolerance induction to tumor cell (GO:0002411)
Namespace: biological_process
Definition: A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor.
antigen transcytosis by M cells in mucosal-associated lymphoid tissue (GO:0002412)
Namespace: biological_process
Definition: The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.
Synonyms: antigen transcytosis by M cells in MALT; antigen transport by M cells in MALT; antigen transport by M cells in mucosal-associated lymphoid tissue
tolerance induction to tumor cell (GO:0002413)
Namespace: biological_process
Definition: A process of tolerance induction which leads to immunological tolerance of a tumor.
immunoglobulin transcytosis in epithelial cells (GO:0002414)
Namespace: biological_process
Definition: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor (GO:0002415)
Namespace: biological_process
Definition: The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
Synonyms: antibody transcytosis mediated by pIgR; immunoglobulin transcytosis mediated by pIgR
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor (GO:0002416)
Namespace: biological_process
Definition: The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.
Synonyms: IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor; IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor
B cell antigen processing and presentation mediated by B cell receptor uptake of antigen (GO:0002417)
Namespace: biological_process
Definition: B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor.
Synonyms: B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen; B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen; B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen
T cell mediated cytotoxicity directed against tumor cell target (GO:0002419)
Namespace: biological_process
Definition: The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Synonyms: T lymphocyte mediated cytotoxicity directed against tumor cell target; T-cell mediated cytotoxicity directed against tumor cell target; T-lymphocyte mediated cytotoxicity directed against tumor cell target
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002420)
Namespace: biological_process
Definition: The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Synonyms: NK cell mediated cytotoxicity directed against tumor cell target
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
B cell antigen processing and presentation following pinocytosis (GO:0002421)
Namespace: biological_process
Definition: B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.
Synonyms: B lymphocyte antigen processing and presentation following pinocytosis; B-cell antigen processing and presentation following pinocytosis; B-lymphocyte antigen processing and presentation following pinocytosis
natural killer cell mediated immune response to tumor cell (GO:0002423)
Namespace: biological_process
Definition: An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell.
T cell mediated immune response to tumor cell (GO:0002424)
Namespace: biological_process
Definition: An immune response mediated by a T cell triggered in response to the presence of a tumor cell.
Comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells.
tolerance induction in urogenital tract (GO:0002425)
Namespace: biological_process
Definition: Tolerance induction taking place in the urogenital tract.
immunoglobulin production in mucosal tissue (GO:0002426)
Namespace: biological_process
Definition: The synthesis and release of immunoglobulin in the mucosal tissue.
Synonyms: antibody production in mucosal tissue
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
mucosal tolerance induction (GO:0002427)
Namespace: biological_process
Definition: Tolerance induction taking place in the mucosal tissues.
antigen processing and presentation of peptide antigen via MHC class Ib (GO:0002428)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family.
Synonyms: peptide antigen processing and presentation via MHC class Ib
immune response-activating cell surface receptor signaling pathway (GO:0002429)
Namespace: biological_process
Definition: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of a cell, leading to the activation or perpetuation of an immune response.
Synonyms: activation of immune response by cell surface receptor signaling pathway; immune response-activating cell surface receptor signalling pathway
complement receptor mediated signaling pathway (GO:0002430)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.
Synonyms: complement receptor mediated signalling pathway; immune response-regulating cell surface receptor signalling pathway
granuloma formation (GO:0002432)
Namespace: biological_process
Definition: The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.
obsolete immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:0002433)
Namespace: biological_process
Definition: OBSOLETE. An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
Synonyms: immune response-regulating cell surface receptor signalling pathway involved in phagocytosis; phagocytosis triggered by activation of immune response cell surface activating receptor
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
immune complex clearance (GO:0002434)
Namespace: biological_process
Definition: A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.
immune complex clearance by erythrocytes (GO:0002435)
Namespace: biological_process
Definition: The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation.
Synonyms: immune complex clearance by RBCs; immune complex clearance by red blood cells
immune complex clearance by monocytes and macrophages (GO:0002436)
Namespace: biological_process
Definition: The process of immune complex clearance by monocytes or macrophages.
inflammatory response to antigenic stimulus (GO:0002437)
Namespace: biological_process
Definition: An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.
acute inflammatory response to antigenic stimulus (GO:0002438)
Namespace: biological_process
Definition: An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
chronic inflammatory response to antigenic stimulus (GO:0002439)
Namespace: biological_process
Definition: A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.
production of molecular mediator of immune response (GO:0002440)
Namespace: biological_process
Definition: The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.
Synonyms: production of cellular mediator of immune response
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
serotonin secretion involved in inflammatory response (GO:0002442)
Namespace: biological_process
Definition: The regulated release of serotonin by a cell as part of an inflammatory response.
Synonyms: serotonin release involved in inflammatory response; serotonin secretion involved in acute inflammatory response
leukocyte mediated immunity (GO:0002443)
Namespace: biological_process
Definition: Any process involved in the carrying out of an immune response by a leukocyte.
Synonyms: cell-mediated immune response; cellular immune response; immune cell effector process; immune cell mediated immunity; leucocyte immune effector process; leucocyte mediated immunity; leukocyte immune effector process
myeloid leukocyte mediated immunity (GO:0002444)
Namespace: biological_process
Definition: Any process involved in the carrying out of an immune response by a myeloid leukocyte.
Synonyms: myeloid leucocyte immune effector process; myeloid leucocyte mediated immunity; myeloid leukocyte immune effector process
type II hypersensitivity (GO:0002445)
Namespace: biological_process
Definition: An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
neutrophil mediated immunity (GO:0002446)
Namespace: biological_process
Definition: Any process involved in the carrying out of an immune response by a neutrophil.
eosinophil mediated immunity (GO:0002447)
Namespace: biological_process
Definition: Any process involved in the carrying out of an immune response by an eosinophil.
mast cell mediated immunity (GO:0002448)
Namespace: biological_process
Definition: Any process involved in the carrying out of an immune response by a mast cell.
lymphocyte mediated immunity (GO:0002449)
Namespace: biological_process
Definition: Any process involved in the carrying out of an immune response by a lymphocyte.
Synonyms: cell-mediated immunity; cellular immune response
B cell antigen processing and presentation (GO:0002450)
Namespace: biological_process
Definition: The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
Synonyms: B lymphocyte antigen processing and presentation; B-cell antigen processing and presentation; B-lymphocyte antigen processing and presentation
peripheral B cell tolerance induction (GO:0002451)
Namespace: biological_process
Definition: Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.
Synonyms: peripheral B lymphocyte tolerance induction; peripheral B-cell tolerance induction; peripheral B-lymphocyte tolerance induction
B cell receptor editing (GO:0002452)
Namespace: biological_process
Definition: The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor.
Synonyms: B lymphocyte receptor editing; B-cell receptor editing; B-lymphocyte receptor editing
peripheral B cell anergy (GO:0002453)
Namespace: biological_process
Definition: Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells.
Synonyms: peripheral B lymphocyte anergy; peripheral B-cell anergy; peripheral B-lymphocyte anergy
peripheral B cell deletion (GO:0002454)
Namespace: biological_process
Definition: The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection.
Synonyms: peripheral B lymphocyte deletion; peripheral B-cell deletion; peripheral B-lymphocyte deletion
humoral immune response mediated by circulating immunoglobulin (GO:0002455)
Namespace: biological_process
Definition: An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
Synonyms: circulating antibody mediated immune response; circulating immunoglobulin mediated immune response; humoral defence mechanism; humoral immune response mediated by circulating antibody
T cell mediated immunity (GO:0002456)
Namespace: biological_process
Definition: Any process involved in the carrying out of an immune response by a T cell.
Synonyms: cell-mediated immunity; cellular immune response; T lymphocyte mediated immunity; T-cell mediated immunity; T-lymphocyte mediated immunity
T cell antigen processing and presentation (GO:0002457)
Namespace: biological_process
Definition: The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
Synonyms: T lymphocyte antigen processing and presentation; T-cell antigen processing and presentation; T-lymphocyte antigen processing and presentation
peripheral T cell tolerance induction (GO:0002458)
Namespace: biological_process
Definition: Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus.
Synonyms: peripheral T lymphocyte tolerance induction; peripheral T-cell tolerance induction; peripheral T-lymphocyte tolerance induction
adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains (GO:0002459)
Namespace: biological_process
Definition: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae).
Synonyms: adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains; adaptive immune response based on somatic recombination of VLR built from LRR domains; adaptive immune response in jawless fish
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460)
Namespace: biological_process
Definition: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
tolerance induction dependent upon immune response (GO:0002461)
Namespace: biological_process
Definition: Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.
Synonyms: immune response-dependent tolerance induction
tolerance induction to nonself antigen (GO:0002462)
Namespace: biological_process
Definition: Tolerance induction in response to nonself antigens.
central tolerance induction to nonself antigen (GO:0002463)
Namespace: biological_process
Definition: Tolerance induction to nonself antigens in the central lymphoid organs.
peripheral tolerance induction to nonself antigen (GO:0002464)
Namespace: biological_process
Definition: Tolerance induction to nonself antigens in the periphery.
peripheral tolerance induction (GO:0002465)
Namespace: biological_process
Definition: Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
peripheral tolerance induction to self antigen (GO:0002466)
Namespace: biological_process
Definition: Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
dendritic cell antigen processing and presentation (GO:0002468)
Namespace: biological_process
Definition: The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
myeloid dendritic cell antigen processing and presentation (GO:0002469)
Namespace: biological_process
Definition: The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
plasmacytoid dendritic cell antigen processing and presentation (GO:0002470)
Namespace: biological_process
Definition: The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
monocyte antigen processing and presentation (GO:0002471)
Namespace: biological_process
Definition: The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
macrophage antigen processing and presentation (GO:0002472)
Namespace: biological_process
Definition: The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
non-professional antigen presenting cell antigen processing and presentation (GO:0002473)
Namespace: biological_process
Definition: The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils.
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
Synonyms: peptide antigen processing and presentation via MHC class I
antigen processing and presentation via MHC class Ib (GO:0002475)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.
antigen processing and presentation of endogenous peptide antigen via MHC class Ib (GO:0002476)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
Synonyms: endogenous peptide antigen processing and presentation via MHC class Ib
antigen processing and presentation of exogenous peptide antigen via MHC class Ib (GO:0002477)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
Synonyms: exogenous peptide antigen processing and presentation via MHC class Ib
antigen processing and presentation of exogenous peptide antigen (GO:0002478)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.
Synonyms: exogenous peptide antigen processing and presentation