LiteFold/GO huggingface dataset:
response to reverse transcriptase inhibitor (GO:0061479)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus.
response to asparaginase (GO:0061480)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus.
response to TNF agonist (GO:0061481)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus.
response to irinotecan (GO:0061482)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus.
obsolete sulfinylpropanyl adenylate synthase activity (GO:0061483)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate.
Synonyms: SPA synthase activity
Comment: This term was obsoleted because it is not known to be catalyzed by any gene product or it represents a specific substrate.
memory T cell proliferation (GO:0061485)
Namespace: biological_process
Definition: The expansion of a memory T cell population by cell division.
high-affinity fructose transmembrane transporter activity (GO:0061486)
Namespace: molecular_function
Definition: Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity fructose transmembrane transporter activity
obsolete DNA replication initiation from late origin (GO:0061487)
Namespace: biological_process
Definition: OBSOLETE. The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase.
Synonyms: late replication origin firing
Comment: The reason for obsoletion is that there is no evidence that this is a different process from its parent term (DNA replication initiation, GO:0006270), but only that regulation of initiation at late origins differs from regulation of initiation at early origins.
obsolete asymmetric protein localization to old or new spindle pole body (GO:0061492)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically.
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
central plaque of mitotic spindle pole body (GO:0061493)
Namespace: cellular_component
Definition: One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body.
half bridge of mitotic spindle pole body (GO:0061496)
Namespace: cellular_component
Definition: Structure adjacent to the plaques of the mitotic spindle pole body.
inner plaque of mitotic spindle pole body (GO:0061497)
Namespace: cellular_component
Definition: One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus.
intermediate layer of mitotic spindle pole body (GO:0061498)
Namespace: cellular_component
Definition: Structure between the central and outer plaques of the mitotic spindle pole body.
outer plaque of mitotic spindle pole body (GO:0061499)
Namespace: cellular_component
Definition: One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm.
2',3'-cyclic GMP-AMP synthase activity (GO:0061501)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP).
Synonyms: 2',3' cyclic GMP-AMP synthase activity; 2',3' cyclic-GMP-AMP synthase activity; cyclic 2',3' GAMP synthase activity; cyclic-GMP-AMP synthase activity
obsolete early endosome to recycling endosome transport (GO:0061502)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.
Comment: This term is described by another GO term
tRNA threonylcarbamoyladenosine dehydratase activity (GO:0061503)
Namespace: molecular_function
Definition: Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A.
cyclic threonylcarbamoyladenosine biosynthetic process (GO:0061504)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.
obsolete DNA topoisomerase type II (ATP-independent) activity (GO:0061506)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Comment: This term was made obsolete because there is no evidence that this function exists. There are no known type II topoisomerase enzymes that are ATP-independent; as far as we know, ALL type II topoisomerase enzymes utilize hydrolysis of ATP.
2',3'-cyclic GMP-AMP binding (GO:0061507)
Namespace: molecular_function
Definition: Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages.
Synonyms: 2',3' cGAMP binding; 2',3' cyclic GAMP binding; 2',3'-cGAMP binding; 2',3'-cyclic GAMP binding; 2',5-3',5'-cyclic GMP-AMP binding; c[G(2',5')pA(3',5')p] binding; cyclic-GMP-AMP binding
obsolete CDP phosphorylation (GO:0061508)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing a phosphate group into CDP to produce a CTP.
Comment: The reason for obsoletion is that this term represents a single step MF.
obsolete asymmetric protein localization to old mitotic spindle pole body (GO:0061509)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically.
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
obsolete asymmetric protein localization to new mitotic spindle pole body (GO:0061510)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically.
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
centriole elongation (GO:0061511)
Namespace: biological_process
Definition: The centrosome organization process by which a centriole increases in length as part of the process of replication.
protein localization to cilium (GO:0061512)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a location within a cilium.
glucose 6-phosphate:phosphate antiporter activity (GO:0061513)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out).
Synonyms: glucose 6-phosphate:inorganic phosphate antiporter activity
interleukin-34-mediated signaling pathway (GO:0061514)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-34 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
myeloid cell development (GO:0061515)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.
monocyte proliferation (GO:0061516)
Namespace: biological_process
Definition: The expansion of a monocyte population by cell division.
macrophage proliferation (GO:0061517)
Namespace: biological_process
Definition: The expansion of a macrophage population by cell division.
microglial cell proliferation (GO:0061518)
Namespace: biological_process
Definition: The expansion of a microglial cell population by cell division.
macrophage homeostasis (GO:0061519)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Langerhans cell differentiation (GO:0061520)
Namespace: biological_process
Definition: The process in which a precursor cell type acquires the specialized features of a Langerhans cell.
hepatic stellate cell differentiation (GO:0061521)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell.
1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity (GO:0061522)
Namespace: molecular_function
Definition: Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+.
cilium disassembly (GO:0061523)
Namespace: biological_process
Definition: A cellular process that results in the breakdown of a cilium.
Synonyms: cilium resorption
Comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
central canal development (GO:0061524)
Namespace: biological_process
Definition: The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord.
hindgut development (GO:0061525)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.
acetylcholine secretion (GO:0061526)
Namespace: biological_process
Definition: The regulated release of acetylcholine by a cell.
dopamine secretion, neurotransmission (GO:0061527)
Namespace: biological_process
Definition: The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter.
aspartate secretion (GO:0061528)
Namespace: biological_process
Definition: The regulated release of aspartate by a cell.
epinephrine secretion, neurotransmission (GO:0061529)
Namespace: biological_process
Definition: The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter.
Synonyms: adrenaline secretion, neurotransmission
aspartate secretion, neurotransmission (GO:0061530)
Namespace: biological_process
Definition: The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter.
primary amine secretion (GO:0061531)
Namespace: biological_process
Definition: The regulated release of a primary amine by a cell.
primary amine secretion, neurotransmission (GO:0061532)
Namespace: biological_process
Definition: The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter.
gamma-aminobutyric acid secretion, neurotransmission (GO:0061534)
Namespace: biological_process
Definition: The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter.
glycine secretion (GO:0061536)
Namespace: biological_process
Definition: The controlled release of glycine by a cell.
glycine secretion, neurotransmission (GO:0061537)
Namespace: biological_process
Definition: The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter.
octopamine secretion (GO:0061539)
Namespace: biological_process
Definition: The controlled release of octopamine by a cell.
octopamine secretion, neurotransmission (GO:0061540)
Namespace: biological_process
Definition: The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter.
rhabdomere morphogenesis (GO:0061541)
Namespace: biological_process
Definition: The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
3-demethylubiquinol 3-O-methyltransferase activity (GO:0061542)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H+.
Synonyms: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase; 3-demethylubiquinol-n 3-O-methyltransferase activity; 5-demethylubiquinone-10 methyltransferase; 5-demethylubiquinone-9 methyltransferase; OMHMB-methyltransferase; S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase
Comment: Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
obsolete 3-demethylubiquinol-6 3-O-methyltransferase activity (GO:0061543)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6.
Comment: This term was obsoleted because it represents a specific substrate of 3-demethylubiquinol-n 3-O-methyltransferase activity ; GO:0061542.
peptide secretion, neurotransmission (GO:0061544)
Namespace: biological_process
Definition: The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter.
tyramine secretion, neurotransmission (GO:0061546)
Namespace: biological_process
Definition: The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter.
sympathetic ganglion development (GO:0061549)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
Synonyms: sympathetic ganglia development
cranial ganglion development (GO:0061550)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.
Synonyms: cranial ganglia development
trigeminal ganglion development (GO:0061551)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.
Synonyms: trigeminal ganglia development
ganglion morphogenesis (GO:0061552)
Namespace: biological_process
Definition: The process in which the anatomical structures of ganglion are generated and organized.
Synonyms: ganglia morphogenesis
ganglion maturation (GO:0061553)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.
Synonyms: ganglia maturation
ganglion formation (GO:0061554)
Namespace: biological_process
Definition: The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.
Synonyms: ganglia formation
ganglion structural organization (GO:0061555)
Namespace: biological_process
Definition: The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure.
Synonyms: ganglia structural organization
trigeminal ganglion morphogenesis (GO:0061556)
Namespace: biological_process
Definition: The process in which the anatomical structure of a trigeminal ganglion is generated and organized.
Synonyms: trigeminal ganglia morphogenesis
trigeminal ganglion maturation (GO:0061557)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state.
Synonyms: trigeminal ganglia maturation
cranial ganglion maturation (GO:0061558)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.
Synonyms: cranial ganglia maturation
cranial ganglion morphogenesis (GO:0061559)
Namespace: biological_process
Definition: The process in which the anatomical structure of a cranial ganglion is generated and organized.
Synonyms: cranial ganglia morphogenesis
cranial ganglion formation (GO:0061560)
Namespace: biological_process
Definition: The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.
Synonyms: cranial ganglia formation
trigeminal ganglion formation (GO:0061561)
Namespace: biological_process
Definition: The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts.
Synonyms: trigeminal ganglia formation
cranial ganglion structural organization (GO:0061562)
Namespace: biological_process
Definition: The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure.
Synonyms: cranial ganglia structural organization
trigeminal ganglion structural organization (GO:0061563)
Namespace: biological_process
Definition: The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure.
Synonyms: trigeminal ganglia organization
axon development (GO:0061564)
Namespace: biological_process
Definition: The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).
dAMP phosphorylation (GO:0061565)
Namespace: biological_process
Definition: The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP.
dCMP phosphorylation (GO:0061567)
Namespace: biological_process
Definition: The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP.
obsolete GDP phosphorylation (GO:0061568)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP.
Comment: The reason for obsoletion is that this term represents a single step MF.
obsolete UDP phosphorylation (GO:0061569)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP.
Comment: The reason for obsoletion is that this term represents a single step MF.
obsolete dCDP phosphorylation (GO:0061570)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing a phosphate group into dCDP to produce a dCTP.
Comment: The reason for obsoletion is that this term represents a single step MF.
obsolete TDP phosphorylation (GO:0061571)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing a phosphate group into TDP to produce a TTP.
Comment: The reason for obsoletion is that this term represents a single step MF.
actin filament bundle organization (GO:0061572)
Namespace: biological_process
Definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.
Synonyms: actin filament cable organization
actin filament bundle retrograde transport (GO:0061573)
Namespace: biological_process
Definition: A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell.
Synonyms: actin filament cable retrograde transport
ASAP complex (GO:0061574)
Namespace: cellular_component
Definition: A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
cyclin-dependent protein serine/threonine kinase activator activity (GO:0061575)
Namespace: molecular_function
Definition: Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.
Synonyms: cyclin-dependent protein kinase 5 activator activity
acyl-CoA ceramide synthase complex (GO:0061576)
Namespace: cellular_component
Definition: A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1.
calcium ion transmembrane transport via high voltage-gated calcium channel (GO:0061577)
Namespace: biological_process
Definition: A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel.
Synonyms: generation of L-type calcium current
K63-linked deubiquitinase activity (GO:0061578)
Namespace: molecular_function
Definition: Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin.
Synonyms: K63-specific deubiquitinase activity; Lys63-specific deubiquitinase activity
N-acyl homoserine lactone synthase activity (GO:0061579)
Namespace: molecular_function
Definition: Catalysis of the reaction: a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H+.
Synonyms: autoinducer-1 synthase
colon epithelial cell migration (GO:0061580)
Namespace: biological_process
Definition: The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.
corneal epithelial cell migration (GO:0061581)
Namespace: biological_process
Definition: The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism.
intestinal epithelial cell migration (GO:0061582)
Namespace: biological_process
Definition: The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.
colon epithelial cell chemotaxis (GO:0061583)
Namespace: biological_process
Definition: The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
orexin secretion (GO:0061584)
Namespace: biological_process
Definition: The controlled release of orexin from a cell or a tissue.
Synonyms: hypocretin secretion
orexin secretion, neurotransmission (GO:0061585)
Namespace: biological_process
Definition: The controlled release of orexin from a cell in which orexin acts as a neurotransmitter.
Synonyms: hypocretin secretion, neurotransmission