LiteFold/GO huggingface dataset:
L-glutamate dehydrogenase (NAD+) activity (GO:0004352)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-glutamate + NAD+ + H2O = 2-oxoglutarate + NH4+ + NADH + H+.
Synonyms: glutamate dehydrogenase (NAD); glutamate dehydrogenase (NAD+) activity; glutamate oxidoreductase activity; glutamic acid dehydrogenase; glutamic dehydrogenase activity; L-glutamate dehydrogenase; L-glutamate:NAD+ oxidoreductase (deaminating); NAD-dependent glutamate dehydrogenase activity; NAD-dependent glutamic dehydrogenase activity; NAD-glutamate dehydrogenase activity; NAD-linked glutamate dehydrogenase activity; NAD-linked glutamic dehydrogenase activity; NAD-specific glutamate dehydrogenase activity; NAD-specific glutamic dehydrogenase activity; NAD:glutamate oxidoreductase activity; NADH-linked glutamate dehydrogenase activity
L-glutamate dehydrogenase [NAD(P)+] activity (GO:0004353)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-glutamate + NAD(P)+ + H2O = 2-oxoglutarate + NH4+ + NAD(P)H + H+.
Synonyms: glutamate dehydrogenase (NAD+) activity; glutamic dehydrogenase activity; L-glutamate:NAD(P)+ oxidoreductase (deaminating)
L-glutamate dehydrogenase (NADP+) activity (GO:0004354)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-glutamate + NADP+ + H2O = 2-oxoglutarate + NH4+ + NADPH + H+.
Synonyms: dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)); glutamic acid dehydrogenase; glutamic dehydrogenase activity; L-glutamate dehydrogenase; L-glutamate:NADP+ oxidoreductase (deaminating); L-glutamic acid dehydrogenase activity; NAD(P)-glutamate dehydrogenase activity; NAD(P)H-dependent glutamate dehydrogenase activity
glutamate synthase (NADPH) activity (GO:0004355)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH4+ = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH4+ + 2-oxoglutarate + NADPH + H+.
Synonyms: glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity; glutamate synthetase (NADP) activity; glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity; glutamine-ketoglutaric aminotransferase activity; GOGAT activity; L-glutamate synthase activity; L-glutamate synthetase activity; L-glutamate:NADP+ oxidoreductase (transaminating); L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity; NADPH GOGAT; NADPH-dependent glutamate synthase activity; NADPH-glutamate synthase activity; NADPH-linked glutamate synthase
glutamine synthetase activity (GO:0004356)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate.
Synonyms: glutamate-ammonia ligase activity; L-glutamine synthetase activity
glutamate-cysteine ligase activity (GO:0004357)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.
Synonyms: gamma-glutamyl-L-cysteine synthetase activity; gamma-glutamylcysteine synthetase activity; gamma-glutamylcysteinyl synthetase activity; L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor (GO:0004358)
Namespace: molecular_function
Definition: Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.
Synonyms: 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity; acetyl-L-glutamate:acetyl-L-ornithine transacetylase activity; acetylglutamate synthetase activity; acetylglutamate-acetylornithine transacetylase activity; acetylglutamic synthetase activity; acetylglutamic-acetylornithine transacetylase activity; acetylornithinase activity; acetylornithine glutamate acetyltransferase activity; alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity; glutamate acetyltransferase activity; glutamate N-acetyltransferase activity; L-glutamate N-acetyltransferase activity; N-acetyl-L-glutamate synthetase activity; N-acetylglutamate synthase activity; N-acetylglutamate synthetase activity; N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity; ornithine acetyltransferase activity; ornithine transacetylase activity
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity (GO:0004360)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.
Synonyms: D-fructose-6-phosphate amidotransferase activity; GlcN6P synthase activity; glucosamine 6-phosphate synthase activity; glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity; glucosamine-6-phosphate isomerase (glutamine-forming) activity; glucosamine-6-phosphate synthase activity; glucosaminephosphate isomerase; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; hexosephosphate aminotransferase activity; L-glutamine-D-fructose-6-phosphate amidotransferase activity; L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
glutaryl-CoA dehydrogenase activity (GO:0004361)
Namespace: molecular_function
Definition: Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein].
Synonyms: glutaryl coenzyme A dehydrogenase activity
glutathione-disulfide reductase (NADPH) activity (GO:0004362)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
Synonyms: glutathione reductase activity; glutathione S-reductase activity; glutathione-disulfide reductase (NADP) activity; glutathione-disulfide reductase activity; glutathione-disulphide reductase activity; glutathione:NADP+ oxidoreductase activity; GSH reductase activity; GSSG reductase activity; NADPH-glutathione reductase activity; NADPH-GSSG reductase activity; NADPH:oxidized-glutathione oxidoreductase activity; oxidized glutathione reduction
glutathione synthase activity (GO:0004363)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.
Synonyms: gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming); glutathione synthetase activity; GSH synthetase activity
glutathione transferase activity (GO:0004364)
Namespace: molecular_function
Definition: Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
Synonyms: glutathione conjugation reaction; glutathione S-alkyl transferase activity; glutathione S-alkyltransferase activity; glutathione S-aralkyltransferase activity; glutathione S-aryltransferase activity; glutathione S-transferase activity; RX:glutathione R-transferase activity; S-(hydroxyalkyl)glutathione lyase activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity (GO:0004365)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.
Synonyms: 3-phosphoglyceraldehyde dehydrogenase activity; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating); dehydrogenase, glyceraldehyde phosphate; GAPDH activity; glyceraldehyde phosphate dehydrogenase (NAD); glyceraldehyde-3-P-dehydrogenase activity; NAD-dependent glyceraldehyde phosphate dehydrogenase activity; NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity; NADH-glyceraldehyde phosphate dehydrogenase activity; phosphoglyceraldehyde dehydrogenase activity; triosephosphate dehydrogenase activity
glycerol-3-phosphate O-acyltransferase activity (GO:0004366)
Namespace: molecular_function
Definition: Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA.
Synonyms: 3-glycerophosphate acyltransferase activity; ACP:sn-glycerol-3-phosphate acyltransferase activity; acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity; alpha-glycerophosphate acyltransferase activity; glycerol 3-phosphate acyltransferase activity; glycerol phosphate acyltransferase activity; glycerol phosphate transacylase activity; glycerophosphate acyltransferase activity; glycerophosphate transacylase activity; sn-glycerol 3-phosphate acyltransferase activity; sn-glycerol-3-phosphate acyltransferase activity
glycerol-3-phosphate dehydrogenase (quinone) activity (GO:0004368)
Namespace: molecular_function
Definition: Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Synonyms: FAD-dependent glycerol-3-phosphate dehydrogenase; flavin-linked glycerol-3-phosphate dehydrogenase; glycerol-3-phosphate CoQ reductase; glycerophosphate dehydrogenase activity; L-glycerophosphate dehydrogenase activity; sn-glycerol-3-phosphate dehydrogenase activity
glycerol-3-phosphate oxidase activity (GO:0004369)
Namespace: molecular_function
Definition: Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2.
Synonyms: alpha-glycerophosphate oxidase activity; glycerol phosphate oxidase activity; glycerol-1-phosphate oxidase activity; L-alpha-glycerol-3-phosphate oxidase activity; L-alpha-glycerophosphate oxidase activity; sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity
glycerol kinase activity (GO:0004370)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+.
Synonyms: ATP:glycerol 3-phosphotransferase activity; ATP:glycerol-3-phosphotransferase activity; GK; glyceric kinase activity; glycerokinase activity; glycerol kinase (phosphorylating)
glycerone kinase activity (GO:0004371)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.
Synonyms: acetol kinase (phosphorylating); acetol kinase activity; ATP:glycerone phosphotransferase activity; dihydroxyacetone kinase activity
glycine hydroxymethyltransferase activity (GO:0004372)
Namespace: molecular_function
Definition: Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine.
Synonyms: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity; allothreonine aldolase activity; L-serine hydroxymethyltransferase activity; serine aldolase activity; serine hydroxymethylase activity; serine hydroxymethyltransferase activity; serine transhydroxymethylase activity
alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity (GO:0004373)
Namespace: molecular_function
Definition: Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H+ + UDP.
Synonyms: glycogen (starch) synthetase activity; glyucogen (starch) synthase activity; UDP-glucose-glycogen glucosyltransferase activity; UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity; UDP-glycogen synthase activity; UDPG-glycogen synthetase activity; UDPG-glycogen transglucosylase activity; UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity; uridine diphosphoglucose-glycogen glucosyltransferase activity
obsolete glycine cleavage system (GO:0004374)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating).
Synonyms: glycine cleavage system; glycine synthase
Comment: This term was made obsolete because it represents a process rather than a function.
GPI mannosyltransferase activity (GO:0004376)
Namespace: molecular_function
Definition: Catalysis of the transfer of an alpha-D-mannosyl residue from dolichol-P-mannose to GlcN-acyl-PI bearing 0-3 mannoses during formation of the GPI precursor.
Synonyms: glycolipid mannosyl transferase activity; glycolipid mannosyltransferase activity
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity (GO:0004377)
Namespace: molecular_function
Definition: Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H+.
Synonyms: GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity; GDP-mannose-oligosaccharide-lipid mannosyltransferase activity; GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity; glycolipid 2-alpha-mannosyltransferase activity; guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity; oligosaccharide-lipid mannosyltransferase activity
GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity (GO:0004378)
Namespace: molecular_function
Definition: Catalysis of the reaction: a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+.
Synonyms: GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity; GDP-mannose-oligosaccharide-lipid mannosyltransferase II; GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity; glycolipid 3-alpha-mannosyltransferase activity; guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity; mannosyltransferase II activity
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity (GO:0004380)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
Synonyms: A transferase activity; A-transferase activity; alpha-3-N-acetylgalactosaminyltransferase activity; blood-group substance A-dependent acetylgalactosaminyltransferase activity; blood-group substance alpha-acetyltransferase activity; fucosylgalactose acetylgalactosaminyltransferase activity; fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity; histo-blood group A acetylgalactosaminyltransferase activity; histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase); histo-blood group A transferase activity; UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity; UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity; UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity
fucosylgalactoside 3-alpha-galactosyltransferase activity (GO:0004381)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
Synonyms: [blood group substance] alpha-galactosyltransferase activity; B transferase activity; blood-group substance B-dependent galactosyltransferase activity; blood-group substance beta-dependent galactosyltransferase activity; fucosylglycoprotein 3-alpha-galactosyltransferase activity; glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity; histo-blood group B transferase activity; histo-blood substance B-dependent galactosyltransferase activity; histo-blood substance beta-dependent galactosyltransferase activity; UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity; UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity; UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity; UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity; UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity; UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity; UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity
GDP phosphatase activity (GO:0004382)
Namespace: molecular_function
Definition: Catalysis of the reaction: GDP + H2O = GMP + phosphate.
Synonyms: GDP diphosphatase activity; GDP phosphohydrolase activity; GDPase activity; guanosine 5'-diphosphatase activity; guanosine diphosphatase activity; guanosine-diphosphatase activity
guanylate cyclase activity (GO:0004383)
Namespace: molecular_function
Definition: Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
Synonyms: GTP diphosphate-lyase (cyclizing) activity; GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity; guanyl cyclase activity; guanylyl cyclase activity; receptor guanylate cyclase activity
obsolete membrane-associated guanylate kinase (GO:0004384)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane.
Synonyms: MAGUK; membrane-associated guanylate kinase
Comment: This term was made obsolete because it represents a gene product and not a function.
GMP kinase activity (GO:0004385)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + GMP = ADP + GDP.
Synonyms: 5'-GMP kinase activity; ATP:(d)GMP phosphotransferase activity; ATP:GMP phosphotransferase activity; deoxyguanylate kinase activity; guanosine monophosphate kinase activity; guanylate kinase activity; membrane-associated guanylate kinase
helicase activity (GO:0004386)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
Synonyms: ATP-dependent helicase activity
Comment: Note that most helicases catalyze processive duplex unwinding.
heparan sulfate 2-sulfotransferase activity (GO:0004394)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.
Synonyms: heparan sulfate 2-O-sulfotransferase activity; heparan-sulfate 2-O-sulphotransferase activity; heparin 2-sulfotransferase activity; heparin-sulphate 2-sulphotransferase activity
obsolete hexaprenyldihydroxybenzoate methyltransferase activity (GO:0004395)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate.
Comment: This term was obsoleted because it represents a specific substrate of 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity ; GO:0010420
hexokinase activity (GO:0004396)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
Synonyms: ATP-dependent hexokinase activity; ATP:D-hexose 6-phosphotransferase activity; glucose ATP phosphotransferase activity; hexokinase (phosphorylating); hexokinase D; hexokinase type I activity; hexokinase type II activity; hexokinase type III activity; hexokinase type IV; hexokinase type IV (glucokinase) activity; hexokinase type IV glucokinase activity
histidine decarboxylase activity (GO:0004398)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-histidine = histamine + CO2.
Synonyms: L-histidine carboxy-lyase (histamine-forming); L-histidine carboxy-lyase activity; L-histidine decarboxylase activity
L-histidinol-phosphate:2-oxoglutarate transaminase activity (GO:0004400)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
Synonyms: glutamic-imidazoleacetol phosphate transaminase activity; histidine:imidazoleacetol phosphate transaminase activity; histidinol phosphate aminotransferase activity; histidinol-phosphate aminotransferase activity; histidinol-phosphate transaminase activity; IAP transaminase activity; imidazole acetol-phosphate transaminase activity; imidazoleacetol phosphate transaminase activity; imidazolylacetolphosphate aminotransferase activity; imidazolylacetolphosphate transaminase activity; L-histidinol phosphate aminotransferase activity; L-histidinol-phosphate:2-oxoglutarate aminotransferase activity
histone acetyltransferase activity (GO:0004402)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl-[histone] + acetyl-CoA = N6-acetyl-L-lysyl-[histone] + CoA + H+.
Synonyms: acetyl-CoA:histone acetyltransferase activity; H2A/H2B histone acetyltransferase activity; H3/H4 histone acetyltransferase activity; H4/H2 histone acetyltransferase activity; H4/H2A acetyltransferase activity; histone acetokinase activity; histone acetylase activity; histone lysine acetyltransferase activity; histone transacetylase activity; nucleosome-histone acetyltransferase activity
histone deacetylase activity (GO:0004407)
Namespace: molecular_function
Definition: Removal of an acetyl group from a lysine residue in a histone.
Synonyms: histone deacetylase activity (NAD-independent)
Comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
holocytochrome-c synthase activity (GO:0004408)
Namespace: molecular_function
Definition: Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.
Synonyms: cytochrome c heme-lyase activity; cytochrome c synthase activity; holocytochrome c synthetase activity; holocytochrome-c apocytochrome-c-lyase (heme-forming); holocytochrome-c apocytochrome-c-lyase activity
homoaconitate hydratase activity (GO:0004409)
Namespace: molecular_function
Definition: Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O.
Synonyms: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]; 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity; cis-homoaconitase activity; HACN activity; homoaconitase activity; Lys4; LysF
homocitrate synthase activity (GO:0004410)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate.
Synonyms: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity; 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating); acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming); acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity; homocitrate synthetase activity
homoserine dehydrogenase activity (GO:0004412)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.
homoserine kinase activity (GO:0004413)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.
Synonyms: ATP:L-homoserine O-phosphotransferase activity; homoserine kinase (phosphorylating); HSK