LiteFold/GO huggingface dataset:
short-chain fatty acyl-CoA dehydrogenase activity (GO:0016937)
Namespace: molecular_function
Definition: Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.
Synonyms: butanoyl-CoA dehydrogenase; butyryl dehydrogenase; short-chain acyl CoA dehydrogenase; short-chain-acyl-CoA dehydrogenase activity; unsaturated acyl-CoA reductase
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
kinesin I complex (GO:0016938)
Namespace: cellular_component
Definition: A complex of two kinesin heavy chains and two kinesin light chains.
kinesin II complex (GO:0016939)
Namespace: cellular_component
Definition: A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes.
natriuretic peptide receptor activity (GO:0016941)
Namespace: molecular_function
Definition: Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
insulin-like growth factor binding protein complex (GO:0016942)
Namespace: cellular_component
Definition: A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development.
Synonyms: IGF binding protein complex
obsolete RNA polymerase I transcription elongation factor activity (GO:0016943)
Namespace: molecular_function
Definition: OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation.
Synonyms: Pol I transcription elongation factor activity; RNA polymerase I transcription elongation factor activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
obsolete RNA polymerase II transcription elongation factor activity (GO:0016944)
Namespace: molecular_function
Definition: OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation.
Synonyms: Pol II transcription elongation factor activity; RNA polymerase II transcription elongation factor activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
obsolete alpha-2 macroglobulin receptor-associated protein activity (GO:0016963)
Namespace: molecular_function
Definition: OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains.
Synonyms: alpha-2 macroglobulin receptor-associated protein activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
nitric oxide reductase activity (GO:0016966)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide.
Synonyms: CYP55; cytochrome bc nitric oxide reductase activity; nitric-oxide reductase activity; nitrogen oxide reductase activity; nitrous-oxide:(acceptor) oxidoreductase (NO-forming); nitrous-oxide:acceptor oxidoreductase (NO-forming); P450 nitric oxide reductase activity; P450nor
obsolete hemerythrin (GO:0016969)
Namespace: molecular_function
Definition: OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans.
Synonyms: hemerythrin
Comment: This term was made obsolete because it represents a gene product.
obsolete hemocyanin (GO:0016970)
Namespace: molecular_function
Definition: OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods.
Synonyms: hemocyanin
Comment: This term was made obsolete because it represents a gene product.
flavin-dependent sulfhydryl oxidase activity (GO:0016971)
Namespace: molecular_function
Definition: Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins.
Synonyms: flavin-linked sulfhydryl oxidase activity
thiol oxidase activity (GO:0016972)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2.
Synonyms: sulfhydryl oxidase activity; thiol:oxygen oxidoreductase activity
poly(A)+ mRNA export from nucleus (GO:0016973)
Namespace: biological_process
Definition: The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
Synonyms: poly(A) mRNA export from nucleus; poly(A)+ mRNA export from cell nucleus; poly(A)+ mRNA export out of nucleus; poly(A)+ mRNA transport from nucleus to cytoplasm; poly(A)+ mRNA-nucleus export; polyadenylated mRNA export from nucleus
chitosanase activity (GO:0016977)
Namespace: molecular_function
Definition: Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan.
Synonyms: chitosan N-acetylglucosaminohydrolase activity
creatinase activity (GO:0016980)
Namespace: molecular_function
Definition: Catalysis of the reaction: creatine + H2O = sarcosine + urea.
Synonyms: creatine amidinohydrolase activity
ribulose-bisphosphate carboxylase activity (GO:0016984)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O.
Synonyms: carboxydismutase activity; D-ribulose 1,5-diphosphate carboxylase activity; D-ribulose-1,5-bisphosphate carboxylase activity; diphosphoribulose carboxylase activity; ribulose 1,5-bisphosphate carboxylase activity; ribulose 1,5-bisphosphate carboxylase/oxygenase activity; ribulose 1,5-diphosphate carboxylase activity; ribulose 1,5-diphosphate carboxylase/oxygenase activity; ribulose bisphosphate carboxylase/oxygenase activity; ribulose diphosphate carboxylase activity; ribulose diphosphate carboxylase/oxygenase activity; RuBisCO activity; RuBP carboxylase activity
mannan endo-1,4-beta-mannosidase activity (GO:0016985)
Namespace: molecular_function
Definition: Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans.
Synonyms: 1,4-beta-D-mannan mannanohydrolase activity; beta-1,4-mannan 4-mannanohydrolase activity; beta-D-mannanase activity; beta-mannanase activity; beta-mannanase B; endo-1,4-beta-mannanase activity; endo-1,4-mannanase activity; endo-beta-1,4-mannase activity; endo-beta-mannanase activity
obsolete transcription initiation factor activity (GO:0016986)
Namespace: molecular_function
Definition: OBSOLETE. Plays a role in regulating transcription initiation.
Synonyms: transcription initiation factor activity; transcriptional initiation factor activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
sigma factor activity (GO:0016987)
Namespace: molecular_function
Definition: Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
Synonyms: bacterial sigma factor activity; core DNA-dependent RNA polymerase binding promoter specificity activity; DNA-dependent RNA polymerase promoter selection factor; plastid sigma factor activity; promoter selection factor activity; sigma transcription factor
obsolete transcription initiation factor antagonist activity (GO:0016988)
Namespace: molecular_function
Definition: OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity.
Synonyms: transcription initiation factor antagonist activity; transcriptional initiation factor antagonist activity
Comment: This term was obsoleted because its definition was vague and apparently broader in scope than the name of the term suggested it was intended to be.
sigma factor antagonist activity (GO:0016989)
Namespace: molecular_function
Definition: The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
Synonyms: anti-sigma factor activity
arginine deiminase activity (GO:0016990)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH4+.
Synonyms: arginine dihydrolase activity; citrulline iminase activity; L-arginine deiminase activity; L-arginine iminohydrolase activity
lipoate synthase activity (GO:0016992)
Namespace: molecular_function
Definition: Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin].
Synonyms: LipA; lipoic acid synthase; lipoyl synthase activity; LS; protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity; protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity
precorrin-8X methylmutase activity (GO:0016993)
Namespace: molecular_function
Definition: Catalysis of the reaction: precorrin-8X = hydrogenobyrinate.
Synonyms: HBA synthase activity; hydrogenobyrinic acid-binding protein activity; precorrin isomerase activity; precorrin-8X 11,12-methylmutase activity
precorrin-6A reductase activity (GO:0016994)
Namespace: molecular_function
Definition: Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+.
Synonyms: precorrin-6B:NADP+ oxidoreductase activity; precorrin-6X reductase activity; precorrin-6Y:NADP(+) oxidoreductase activity; precorrin-6Y:NADP+ oxidoreductase activity
cholesterol oxidase activity (GO:0016995)
Namespace: molecular_function
Definition: Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2.
Synonyms: 3beta-hydroxy steroid oxidoreductase activity; 3beta-hydroxysteroid:oxygen oxidoreductase activity; cholesterol- O2 oxidoreductase activity; cholesterol-O2 oxidoreductase activity; cholesterol:oxygen oxidoreductase activity
endo-alpha-(2,8)-sialidase activity (GO:0016996)
Namespace: molecular_function
Definition: Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids.
Synonyms: alpha-2,8-sialosylhydrolase activity; endo-N-acetylneuraminidase activity; endo-N-acylneuraminidase activity; endoneuraminidase activity; endosialidase activity; poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity; poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity; polysialoside (2->8)-alpha-sialosylhydrolase activity
alpha-sialidase activity (GO:0016997)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids.
cell wall macromolecule catabolic process (GO:0016998)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.
Synonyms: cell wall breakdown; cell wall catabolism; cell wall degradation; cellular cell wall macromolecule breakdown; cellular cell wall macromolecule catabolic process; cellular cell wall macromolecule catabolism; cellular cell wall macromolecule degradation
antibiotic metabolic process (GO:0016999)
Namespace: biological_process
Definition: The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
Synonyms: antibiotic metabolism
antibiotic catabolic process (GO:0017001)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
Synonyms: antibiotic breakdown; antibiotic catabolism; antibiotic degradation
activin receptor activity (GO:0017002)
Namespace: molecular_function
Definition: Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
Synonyms: activin-activated receptor activity
Comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand activin. For binding to other extracellular ligands, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
protein-heme linkage (GO:0017003)
Namespace: biological_process
Definition: The covalent linkage of heme and a protein.
Synonyms: protein-haem linkage
cytochrome complex assembly (GO:0017004)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
Synonyms: cytochrome biogenesis
3'-tyrosyl-DNA phosphodiesterase activity (GO:0017005)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA.
Comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
protein-tetrapyrrole linkage (GO:0017006)
Namespace: biological_process
Definition: The covalent linking of a tetrapyrrole to a protein.
protein-bilin linkage (GO:0017007)
Namespace: biological_process
Definition: The covalent linkage of bilin and a protein.
protein-phycobiliviolin linkage (GO:0017008)
Namespace: biological_process
Definition: The linkage of the chromophore phycobiliviolin to phycoerythrocyanin.
protein-phycocyanobilin linkage (GO:0017009)
Namespace: biological_process
Definition: The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin.
protein-phycourobilin linkage (GO:0017010)
Namespace: biological_process
Definition: The linkage of the chromophore phycourobilin to phycoerythrins.
protein-phycoerythrobilin linkage (GO:0017011)
Namespace: biological_process
Definition: The linkage of the chromophore phycoerythrobilin to phycoerythrins.
protein-phytochromobilin linkage (GO:0017012)
Namespace: biological_process
Definition: The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin.
protein flavinylation (GO:0017013)
Namespace: biological_process
Definition: The addition of a flavin group to a protein amino acid.
Synonyms: protein amino acid flavinylation
protein nitrosylation (GO:0017014)
Namespace: biological_process
Definition: The covalent addition of a nitric oxide group to an amino acid within a protein.
Synonyms: protein amino acid nitrosylation
MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017)
Namespace: molecular_function
Definition: Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.
Synonyms: dual-specificity MAP kinase phosphatase activity
myosin phosphatase activity (GO:0017018)
Namespace: molecular_function
Definition: Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
Synonyms: myosin phosphatase myosin binding; myosin phosphatase, intrinsic catalyst activity
myosin phosphatase regulator activity (GO:0017020)
Namespace: molecular_function
Definition: Binds to and modulates of the activity of myosin phosphatase.
Synonyms: myosin phosphatase, intrinsic regulator activity
obsolete myosin phosphatase myosin binding (GO:0017021)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: myosin phosphatase myosin binding
Comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function.
myosin binding (GO:0017022)
Namespace: molecular_function
Definition: Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
Synonyms: myosin phosphatase myosin binding
myosin phosphatase complex (GO:0017023)
Namespace: cellular_component
Definition: An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A).
myosin I binding (GO:0017024)
Namespace: molecular_function
Definition: Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.
TBP-class protein binding (GO:0017025)
Namespace: molecular_function
Definition: Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
Synonyms: TATA-binding protein binding; TBP binding; TBP-related factor (TRF) protein binding
obsolete procollagen C-endopeptidase activity (GO:0017026)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III.
Synonyms: BMP1; carboxyprocollagen peptidase activity; procollagen C-endopeptidase activity; procollagen C-proteinase activity; procollagen C-terminal peptidase activity; procollagen C-terminal proteinase activity; procollagen carboxy-terminal proteinase activity; procollagen carboxypeptidase activity; procollagen peptidase activity
Comment: This term was made obsolete because it represents a gene product.
obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity (GO:0017027)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: transmembrane receptor protein serine/threonine kinase receptor-associated protein activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
obsolete protein stabilization activity (GO:0017028)
Namespace: molecular_function
Definition: OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds.
Synonyms: protein stabilization activity
Comment: This term was made obsolete because it represents a biological process.
obsolete lysosomal protein stabilization (GO:0017029)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: lysosomal protein stabilization
Comment: This term was made obsolete because it contains both component and function information.
obsolete beta-galactosidase stabilization activity (GO:0017030)
Namespace: molecular_function
Definition: OBSOLETE. Stabilization of the structure of beta-galactosidase.
Synonyms: beta-galactosidase stabilization activity
Comment: This term was made obsolete because it represents a biological process.
amino acid:potassium symporter activity (GO:0017032)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in).
Synonyms: potassium:amino acid symporter activity
protein import (GO:0017038)
Namespace: biological_process
Definition: The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
Synonyms: protein uptake