LiteFold/GO huggingface dataset:
response to mitotic cell cycle spindle orientation checkpoint signaling (GO:0072482)
Namespace: biological_process
Definition: A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling.
Synonyms: mitotic cell cycle spindle orientation checkpoint effector process; response to signal involved in mitotic cell cycle spindle orientation checkpoint
obsolete detection of stimulus involved in spindle assembly checkpoint (GO:0072484)
Namespace: biological_process
Definition: OBSOLETE. The series of events in which information about spindle assembly is received and converted into a molecular signal, contributing to a spindle assembly checkpoint.
Synonyms: sensing involved in spindle assembly checkpoint; spindle assembly checkpoint sensor mechanism; spindle assembly checkpoint sensor process
Comment: This term was obsoleted because it corresponds to a molecular function.
response to spindle assembly checkpoint signaling (GO:0072485)
Namespace: biological_process
Definition: A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling.
Synonyms: response to signal involved in spindle assembly checkpoint; spindle assembly checkpoint effector process
MSL complex (GO:0072487)
Namespace: cellular_component
Definition: A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.
obsolete toluene-containing compound metabolic process (GO:0072490)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives.
Synonyms: toluene and derivative metabolic process; toluene-containing compound metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
toluene-containing compound catabolic process (GO:0072491)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives.
Synonyms: toluene and derivative catabolic process; toluene-containing compound breakdown; toluene-containing compound catabolism; toluene-containing compound degradation
host cell mitochondrial intermembrane space (GO:0072492)
Namespace: cellular_component
Definition: The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope.
host cell endosome lumen (GO:0072493)
Namespace: cellular_component
Definition: The volume enclosed by the membranes of the host cell endosome.
Synonyms: host endosome lumen
host multivesicular body (GO:0072494)
Namespace: cellular_component
Definition: A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm.
Synonyms: host cell multivesicular body
host cell Cajal body (GO:0072495)
Namespace: cellular_component
Definition: A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction.
Synonyms: coiled body of host; host cell coiled body
Pup transferase activity (GO:0072496)
Namespace: molecular_function
Definition: Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages.
Synonyms: Pup conjugating enzyme activity
mesenchymal stem cell differentiation (GO:0072497)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.
embryonic skeletal joint development (GO:0072498)
Namespace: biological_process
Definition: The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.
photoreceptor cell axon guidance (GO:0072499)
Namespace: biological_process
Definition: The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues.
Synonyms: photoreceptor cell axon pathfinding
obsolete negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor (GO:0072500)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Synonyms: negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
Comment: This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand.
obsolete cellular trivalent inorganic anion homeostasis (GO:0072502)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete divalent inorganic anion homeostasis (GO:0072505)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell.
Comment: This term was obsoleted because it represents an unnecessary grouping class.
obsolete trivalent inorganic anion homeostasis (GO:0072506)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete divalent inorganic cation homeostasis (GO:0072507)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete trivalent inorganic cation homeostasis (GO:0072508)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell.
Comment: This term was obsoleted because it is an unnecessary grouping class.
positive regulation of secondary heart field cardioblast proliferation (GO:0072513)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).
Synonyms: negative regulation of second heart field cardioblast proliferation
trehalose transport in response to water deprivation (GO:0072514)
Namespace: biological_process
Definition: The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water.
trehalose transport in response to desiccation (GO:0072515)
Namespace: biological_process
Definition: The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water.
host cell viral assembly compartment (GO:0072517)
Namespace: cellular_component
Definition: A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place.
Synonyms: host cell viral assembly site; host cell virion assembly compartment; viral assembly compartment; viral assembly site; virion assembly compartment
seminiferous tubule development (GO:0072520)
Namespace: biological_process
Definition: The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.
purine-containing compound metabolic process (GO:0072521)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.
Synonyms: purine and derivative metabolic process; purine-containing compound metabolism
purine-containing compound biosynthetic process (GO:0072522)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.
Synonyms: purine and derivative biosynthetic process; purine-containing compound anabolism; purine-containing compound biosynthesis; purine-containing compound formation; purine-containing compound synthesis
pyridine-containing compound metabolic process (GO:0072524)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.
Synonyms: pyridine and derivative metabolic process; pyridine-containing compound metabolism
pyridine-containing compound biosynthetic process (GO:0072525)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.
Synonyms: pyridine and derivative biosynthetic process; pyridine-containing compound anabolism; pyridine-containing compound biosynthesis; pyridine-containing compound formation; pyridine-containing compound synthesis
pyridine-containing compound catabolic process (GO:0072526)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.
Synonyms: pyridine and derivative catabolic process; pyridine-containing compound breakdown; pyridine-containing compound catabolism; pyridine-containing compound degradation
pyrimidine-containing compound biosynthetic process (GO:0072528)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.
Synonyms: pyrimidine and derivative biosynthetic process; pyrimidine-containing compound anabolism; pyrimidine-containing compound biosynthesis; pyrimidine-containing compound formation; pyrimidine-containing compound synthesis
pyrimidine-containing compound catabolic process (GO:0072529)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.
Synonyms: pyrimidine and derivative catabolic process; pyrimidine-containing compound breakdown; pyrimidine-containing compound catabolism; pyrimidine-containing compound degradation
purine-containing compound transmembrane transport (GO:0072530)
Namespace: biological_process
Definition: The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof.
Synonyms: purine-containing compound membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
pyrimidine-containing compound transmembrane transport (GO:0072531)
Namespace: biological_process
Definition: The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof.
Synonyms: pyrimidine-containing compound membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity (GO:0072532)
Namespace: molecular_function
Definition: Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives.
Comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-triferuloyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tri-(hydroxyferuloyl)-spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11262 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11262) and the KEGG reaction R08986 (http://www.genome.jp/dbget-bin/www_bget?rn:R08986).
tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity (GO:0072533)
Namespace: molecular_function
Definition: Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives.
Comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-tricoumaroyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tricaffeoyl spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11260 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11260).
perineuronal net (GO:0072534)
Namespace: cellular_component
Definition: A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.
Synonyms: PNN
tumor necrosis factor (ligand) superfamily member 11 production (GO:0072535)
Namespace: biological_process
Definition: The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: RANKL production; TNFSF11 production; tumor necrosis factor ligand superfamily member 11 production
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
interleukin-23 receptor complex (GO:0072536)
Namespace: cellular_component
Definition: A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.
Synonyms: IL-23 receptor complex
fibroblast activation (GO:0072537)
Namespace: biological_process
Definition: A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.
T-helper 17 cell differentiation (GO:0072539)
Namespace: biological_process
Definition: The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Synonyms: T-helper 17 cell development
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
T-helper 17 cell lineage commitment (GO:0072540)
Namespace: biological_process
Definition: The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Synonyms: T-helper 17 cell fate commitment; Th17 cell lineage commitment; Th17 fate commitment
peroxynitrite reductase activity (GO:0072541)
Namespace: molecular_function
Definition: Catalysis of the reaction: [protein]-dithiol + ONOO- = [protein]-disulfide + NO2- + H2O.
Synonyms: peroxynitritase activity
Comment: Note that this activity is usually associated in vivo with an NADPH-dependent disulfide reductase activity, so that catalysis of the reduction of peroxynitrite to nitrite involves the possible creation of oxygen or water, using NADPH as reduction equivalent.
L-DOPA binding (GO:0072544)
Namespace: molecular_function
Definition: Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid.
L-tyrosine binding (GO:0072545)
Namespace: molecular_function
Definition: Binding to L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
Synonyms: L-Tyr binding; tyrosine binding
EMC complex (GO:0072546)
Namespace: cellular_component
Definition: A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
Synonyms: endoplasmic reticulum membrane protein complex; ER membrane protein complex
Comment: Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect.
tricoumaroylspermidine meta-hydroxylase activity (GO:0072547)
Namespace: molecular_function
Definition: Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O.
Synonyms: tricoumaroyl spermidine meta-hydroxylase activity
dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity (GO:0072548)
Namespace: molecular_function
Definition: Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O.
monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity (GO:0072549)
Namespace: molecular_function
Definition: Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O.
diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity (GO:0072551)
Namespace: molecular_function
Definition: Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O.
monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity (GO:0072552)
Namespace: molecular_function
Definition: Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O.
terminal button organization (GO:0072553)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.
Synonyms: bouton organization; presynaptic bouton organization; synaptic bouton organization; terminal bouton organization; terminal button organisation
obsolete 17-beta-ketosteroid reductase (NADPH) activity (GO:0072555)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+.
Synonyms: 7beta-ketosteroid reductase activity
Comment: This term was obsoleted because it was an unnecessary grouping term.
IPAF inflammasome complex (GO:0072557)
Namespace: cellular_component
Definition: An inflammasome complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.
NLRP1 inflammasome complex (GO:0072558)
Namespace: cellular_component
Definition: An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.
Synonyms: NALP1 inflammasome complex
NLRP3 inflammasome complex (GO:0072559)
Namespace: cellular_component
Definition: An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
Synonyms: NALP3 inflammasome complex
type B pancreatic cell maturation (GO:0072560)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
Synonyms: pancreatic B cell maturation; pancreatic beta cell maturation
Comment: These processes continue to 60 DPA in Gossypium spp.
blood microparticle (GO:0072562)
Namespace: cellular_component
Definition: A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
Synonyms: cell membrane microparticle
endothelial microparticle (GO:0072563)
Namespace: cellular_component
Definition: A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell.
blood microparticle formation (GO:0072564)
Namespace: biological_process
Definition: The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell.
Synonyms: microparticle generation; microparticle release
endothelial microparticle formation (GO:0072565)
Namespace: biological_process
Definition: The cellular component organization process in which microparticles bud off from an endothelial cell.
Synonyms: endothelial microparticle generation; endothelial microparticle release
chemokine (C-X-C motif) ligand 1 production (GO:0072566)
Namespace: biological_process
Definition: The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CXCL1 production; KC production; keratinocyte derived chemokine production; SCYB1 production