LiteFold/GO huggingface dataset:
ABC-type polyamine transporter activity (GO:0015417)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in).
Synonyms: ATP-dependent polyamine transmembrane transporter activity; ATPase-coupled polyamine transmembrane transporter activity; ATPase-coupled spermidine transmembrane transporter activity; polyamine ABC transporter; polyamine porter activity; polyamine-importing ATPase activity; polyamine-transporting ATPase activity; spermidine porter activity; spermidine-importing ATPase activity
ABC-type quaternary ammonium compound transporting activity (GO:0015418)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in).
Synonyms: ATP-dependent quaternary-ammonium compound transmembrane transporting activity; ATPase-coupled quaternary ammonium compound transmembrane transporting activity; glycine betaine/proline porter activity; quarternary amine transporter activity; quaternary amine uptake transporter activity; quaternary-amine-transporting ATPase activity; quaternary-ammonium-compound ABC transporter; quaternary-ammonium-compound-transporting ATPase activity
ABC-type sulfate transporter activity (GO:0015419)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in).
Synonyms: ATPase-coupled sulfate transmembrane transporter activity; sulfate ABC transporter; sulfate transmembrane-transporting ATPase activity; sulfate-transporting ATPase activity; sulfate/thiosulfate porter activity; sulphate transporting ATPase activity
ABC-type vitamin B12 transporter activity (GO:0015420)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin.
Synonyms: ATP-dependent cobalamin transmembrane transporter activity; ATP-dependent vitamin B12 transmembrane transporter activity; ATPase-coupled cobalamin transmembrane transporter activity; ATPase-coupled vitamin B12 transmembrane transporter activity; cobalamin ABC transporter; cobalamin porter activity; cobalamin transporter activity; cobalamin-transporting ATPase activity; vitamin B12 ABC transporter activity; vitamin B12 porter activity; vitamin B12 transporter activity; vitamin B12-transporting ATPase activity
ABC-type oligopeptide transporter activity (GO:0015421)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in).
Synonyms: ABC-type oligopeptide transporter; ATP-dependent oligopeptide transmembrane transporter activity; ATPase-coupled oligopeptide transmembrane transporter activity; oligopeptide ABC transporter; oligopeptide permease activity; oligopeptide-transporting ATPase activity
ABC-type oligosaccharide transporter activity (GO:0015422)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in).
Synonyms: ABC-type oligosaccharide transporter; ATP-dependent oligosaccharide transmembrane transporter activity; ATPase-coupled oligosaccharide transmembrane transporter activity; oligosaccharide ABC transporter; oligosaccharide-transporting ATPase activity
ABC-type maltose transporter activity (GO:0015423)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in).
Synonyms: ABC-type maltose transporter; ATP-dependent maltose transmembrane transporter activity; ATPase-coupled maltose transmembrane transporter activity; maltooligosaccharide-importing ATPase activity; maltose ABC transporter; maltose-transporting ATPase activity
ABC-type amino acid transporter activity (GO:0015424)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out).
Synonyms: amino acid ABC transporter; amino acid-exporting ATPase activity; amino acid-importing ATPase activity; amino acid-transporting ATPase activity; ATP-dependent amino acid transmembrane transporter activity; ATPase-coupled amino acid transmembrane transporter activity
ATPase-coupled nonpolar-amino acid transporter activity (GO:0015425)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in).
Synonyms: ATP-dependent nonpolar-amino acid transporter activity; leucine/isoleucine/valine porter activity; nonpolar amino acid-transporting ATPase activity; nonpolar-amino acid ABC transporter; nonpolar-amino acid-transporting ATPase activity; nonpolar-amino-acid-transporting ATPase activity
ATPase-coupled polar amino acid-transporter activity (GO:0015426)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in).
Synonyms: ATP-dependent polar amino acid-transporter activity; cystine/diaminopimelate porter activity; glutamate/aspartate porter activity; histidine permease activity; histidine/arginine/lysine/ornithine porter activity; polar amino acid uptake transporter activity; polar amino acid-importing ATPase activity; polar-amino acid ABC transporter; polar-amino acid-importing ATPase activity; polar-amino acid-transporting ATPase activity; polar-amino-acid-transporting ATPase activity
obsolete type I protein secretor activity (GO:0015428)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: type I protein secretor activity
Comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
obsolete peroxisomal fatty acyl transporter (GO:0015429)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: peroxisomal fatty acyl transporter
Comment: This term was made obsolete because it describes a gene product and it contains both component and function information.
ABC-type glycerol-3-phosphate transporter activity (GO:0015430)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in).
Synonyms: ABC-type glycerol 3-phosphate transporter; ATP-dependent glycerol-2-phosphate transmembrane transporter activity; ATPase-coupled glycerol-2-phosphate transmembrane transporter activity; ATPase-coupled glycerol-3-phosphate transmembrane transporter activity; glycerol phosphate-importing ATPase activity; glycerol-2-phosphate-transporting ATPase activity; glycerol-3-phosphate ABC transporter; glycerol-3-phosphate-transporting ATPase; glycerol-phosphate porter activity
ABC-type bile acid transporter activity (GO:0015432)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cholate(in) + ATP + H2O = cholate(out) + ADP + phosphate + H+.
Synonyms: ATP-dependent bile acid transmembrane transporter activity; ATPase-coupled bile acid transmembrane transporter activity; bile acid porter activity; bile acid-exporting ATPase activity
obsolete ABC-type efflux permease activity (GO:0015435)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: ABC-type efflux permease activity
Comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
ABC-type capsular-polysaccharide transporter activity (GO:0015436)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out).
Synonyms: ATP phosphohydrolase (capsular-polysaccharide-exporting); ATP-dependent capsular-polysaccharide transporter activity; ATPase-coupled capsular-polysaccharide transporter activity; capsular-polysaccharide ABC transporter; capsular-polysaccharide-transporting ATPase activity
lipopolysaccharide floppase activity (GO:0015437)
Namespace: molecular_function
Definition: Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: ATP-dependent intramembrane lipopolysaccharide transporter activity; ATPase-coupled intramembrane lipopolysaccharide transporter activity; lipopolysaccharide floppase activity (cytosolic to exoplasmic leaflet); lipopolysaccharide-transporting ATPase activity; LPS-transporting ATPase activity
ABC-type teichoic acid transporter activity (GO:0015438)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out).
Synonyms: ABC-type teichoic-acid transporter; ATP-dependent teichoic acid transmembrane transporter activity; ATPase-coupled teichoic acid transmembrane transporter activity; teichoic acid transmembrane transporter activity; teichoic-acid ABC transporter; teichoic-acid-transporting ATPase activity
ABC-type heme transporter activity (GO:0015439)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out).
Synonyms: ATP-dependent heme transmembrane transporter activity; ATPase-coupled heme transmembrane transporter activity; ATPase-coupled heme transporter activity; haem-transporting ATPase activity; heme ABC transporter; heme-transporting ATPase activity; protoheme IX ABC transporter activity
ABC-type peptide transporter activity (GO:0015440)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.
Synonyms: ATP-dependent peptide transmembrane transporter activity; ATPase-coupled peptide transmembrane transporter activity; peptide ABC transporter; peptide-transporting ATPase activity
ABC-type beta-glucan transporter activity (GO:0015441)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out).
Synonyms: ABC-type beta-glucan transporter; ATP-dependent beta-glucan transporter activity; ATPase-coupled beta-glucan transporter activity; beta-glucan ABC transporter; beta-glucan-transporting ATPase activity
obsolete hydrogen-/sodium-translocating ATPase activity (GO:0015442)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out).
Synonyms: hydrogen-/sodium-translocating ATPase activity; proton-/sodium-translocating ATPase activity
Comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification.
obsolete sodium-transporting two-sector ATPase activity (GO:0015443)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out).
Synonyms: sodium-transporting two-sector ATPase activity
Comment: This term was made obsolete because it refers to a bifunctional gene product.
P-type magnesium transporter activity (GO:0015444)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in).
Synonyms: ATP phosphohydrolase (Mg2+-importing); magnesium importing ATPase activity; magnesium transmembrane transporter activity, phosphorylative mechanism; magnesium-translocating P-type ATPase activity; Mg(2+)-importing ATPase activity; Mg2+-importing ATPase activity
ATPase-coupled arsenite transmembrane transporter activity (GO:0015446)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out).
Synonyms: arsenical pump-driving ATPase activity; arsenical resistance ATPase activity; arsenical resistance efflux pump; arsenite ABC transporter; arsenite transporting ATPase activity; arsenite-translocating ATPase activity; arsenite-transmembrane transporting ATPase activity; arsenite-transporting ATPase activity
Comment: EC:7.3.2.7 states that this bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. Like ABC transporters, it contains two nucleotide binding sites (PMID:10970874).
obsolete type II protein secretor activity (GO:0015447)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: type II protein secretor activity
Comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
obsolete type III protein (virulence-related) secretor activity (GO:0015448)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: type III protein (virulence-related) secretor activity
Comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
obsolete type IV protein (DNA-protein) secretor activity (GO:0015449)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: type IV protein (DNA-protein) secretor activity
Comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
protein-transporting ATPase activity (GO:0015450)
Namespace: molecular_function
Definition: Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.
Synonyms: P-P-bond-hydrolysis-driven protein transmembrane transporter activity; protein translocase activity
decarboxylation-driven active transmembrane transporter activity (GO:0015451)
Namespace: molecular_function
Definition: Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
Synonyms: decarboxylation-driven transporter
methyl transfer-driven active transmembrane transporter activity (GO:0015452)
Namespace: molecular_function
Definition: Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
Synonyms: Methyltransfer-driven transporters
oxidoreduction-driven active transmembrane transporter activity (GO:0015453)
Namespace: molecular_function
Definition: Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
Synonyms: oxidoreduction-driven transporter
light-driven active monoatomic ion transmembrane transporter activity (GO:0015454)
Namespace: molecular_function
Definition: Active transport of an ion across a membrane, driven by light.
Synonyms: light absorption-driven transporter; light-driven active ion transmembrane transporter activity; light-driven active transmembrane transporter activity; light-driven pumps
potassium channel regulator activity (GO:0015459)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a potassium channel.
Synonyms: potassium channel gating activity
obsolete endosomal oligosaccharide transporter (GO:0015461)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: endosomal oligosaccharide transporter
Comment: This term was made obsolete because it contains both component and function information.
ABC-type protein transporter activity (GO:0015462)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in).
Synonyms: ABC-type protein transmembrane transporter activity; ATPase-coupled protein transmembrane transporter activity; pilin/fimbrilin exporter activity; protein ABC transporter; protein-transmembrane transporting ATPase activity; protein-transporting ATPase activity
Comment: Enzymes with this activity include bacterial enzymes dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families, for example alpha-hemolysin, cyclolysin, colicin V, siderophores, bacteriocin, subtilin, competence factor and pediocin (from EC:7.4.2.5).
acetylcholine receptor activity (GO:0015464)
Namespace: molecular_function
Definition: Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'.
obsolete lysin activity (GO:0015465)
Namespace: molecular_function
Definition: OBSOLETE. An agent that can lyse cells.
Synonyms: lysin activity
Comment: This term was made obsolete because it represents a class of gene products.
G-protein activated inward rectifier potassium channel activity (GO:0015467)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
Synonyms: G protein activated inward rectifier potassium channel activity; G protein enhanced inward rectifier potassium channel activity; G-protein enhanced inward rectifier potassium channel activity; G-protein-activated inward rectifier potassium channel activity; G-protein-enhanced inward rectifier potassium channel activity
obsolete colicin (GO:0015468)
Namespace: molecular_function
Definition: OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it.
Synonyms: colicin
Comment: This term was made obsolete because it represents a class of gene products.
obsolete channel-forming toxin activity (GO:0015469)
Namespace: molecular_function
Definition: OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell.
Synonyms: channel-forming toxin activity
Comment: This term was made obsolete because it represents a class of gene products.
obsolete bacteriocin activity (GO:0015470)
Namespace: molecular_function
Definition: OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor.
Synonyms: bacteriocin activity
Comment: This term was made obsolete because it represents a gene product.
nucleoside-specific channel forming porin activity (GO:0015471)
Namespace: molecular_function
Definition: Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
obsolete fimbrium-specific chaperone activity (GO:0015472)
Namespace: molecular_function
Definition: OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function.
Synonyms: fimbrium-specific chaperone activity
Comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function.
fimbrial usher porin activity (GO:0015473)
Namespace: molecular_function
Definition: A porin that acts in the assembly of fimbria together with fimbrial chaperone.
autotransporter activity (GO:0015474)
Namespace: molecular_function
Definition: Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively.
obsolete adhesin autotransporter activity (GO:0015475)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively.
Comment: The reason for obsoletion is that this term represents a specific substrate of the parent GO:0015474 autotransporter activity.
obsolete receptor porin activity (GO:0015477)
Namespace: molecular_function
Definition: OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane.
Synonyms: receptor porin activity
Comment: This term was made obsolete because it combines two functions that are not linked.
oligosaccharide transporting porin activity (GO:0015478)
Namespace: molecular_function
Definition: Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
Synonyms: raffinose porin