LiteFold/GO huggingface dataset:
primary miRNA binding (GO:0070878)
Namespace: molecular_function
Definition: Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
Synonyms: pri-miRNA binding; primary microRNA binding
regulation of proline transport (GO:0070881)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of proline transport.
pre-miRNA binding (GO:0070883)
Namespace: molecular_function
Definition: Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.
Synonyms: pre-microRNA binding; precursor microRNA binding
regulation of calcineurin-NFAT signaling cascade (GO:0070884)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
Synonyms: NFAT protein import into nucleus; regulation of calcineurin-NFAT signaling pathway; regulation of calcineurin-NFAT signalling cascade; regulation of NFAT protein import into nucleus
negative regulation of calcineurin-NFAT signaling cascade (GO:0070885)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.
Synonyms: down regulation of calcineurin-NFAT signaling cascade; down-regulation of calcineurin-NFAT signaling cascade; downregulation of calcineurin-NFAT signaling cascade; inhibition of calcineurin-NFAT signaling cascade; inhibition of NFAT protein import into nucleus; negative regulation of calcineurin-NFAT signaling pathway; negative regulation of calcineurin-NFAT signalling cascade; negative regulation of NFAT protein import into nucleus; termination of calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade (GO:0070886)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
Synonyms: activation of calcineurin-NFAT signaling cascade; positive regulation of calcineurin-NFAT signaling pathway; positive regulation of calcineurin-NFAT signalling cascade; positive regulation of NFAT protein import into nucleus; stimulation of calcineurin-NFAT signaling cascade; up regulation of calcineurin-NFAT signaling cascade; up-regulation of calcineurin-NFAT signaling cascade; upregulation of calcineurin-NFAT signaling cascade
cellular response to chemical stimulus (GO:0070887)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
E-box binding (GO:0070888)
Namespace: molecular_function
Definition: Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
Synonyms: E-box promoter binding
platelet alpha granule organization (GO:0070889)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets.
Synonyms: platelet alpha granule organisation; platelet alpha granule organization and biogenesis; platelet alpha-granule organization
lipoteichoic acid binding (GO:0070891)
Namespace: molecular_function
Definition: Binding to lipoteichoic acid.
lipoteichoic acid immune receptor activity (GO:0070892)
Namespace: molecular_function
Definition: Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response.
Synonyms: lipoteichoic acid receptor activity
obsolete transposon integration (GO:0070893)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome.
Comment: This term was obsoleted because it represents a readout.
obsolete regulation of transposon integration (GO:0070894)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.
Comment: This term was obsoleted because it represents a readout.
obsolete negative regulation of transposon integration (GO:0070895)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.
Synonyms: down regulation of transposon integration; down-regulation of transposon integration; downregulation of transposon integration; inhibition of transposon integration
Comment: This term was obsoleted because it represents a readout.
obsolete positive regulation of transposon integration (GO:0070896)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.
Synonyms: activation of transposon integration; stimulation of transposon integration; up regulation of transposon integration; up-regulation of transposon integration; upregulation of transposon integration
Comment: This term was obsoleted because it represents a readout.
transcription preinitiation complex assembly (GO:0070897)
Namespace: biological_process
Definition: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides.
Synonyms: bacterial-type RNA polymerase preinitiation complex assembly; bacterial-type RNA polymerase transcription PIC formation; bacterial-type RNA polymerase transcriptional preinitiation complex formation; DNA-dependent transcriptional preinitiation complex assembly; DNA-templated transcriptional preinitiation complex assembly; transcription PIC biosynthesis; transcription PIC formation; transcriptional preinitiation complex formation
RNA polymerase III preinitiation complex assembly (GO:0070898)
Namespace: biological_process
Definition: The formation of a large multiprotein-DNA complex that self-assembles on a tRNA gene through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC), (which includes BDP1, BRF1, TBP, TFIIIC in human). The PIC engages RNA polymerase III on its DNA template strand and sparks polymerization of the first few RNA nucleotides.
Synonyms: RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly; RNA polymerase III transcription PIC biosynthesis; RNA polymerase III transcription PIC formation; RNA polymerase III transcriptional preinitiation complex assembly; RNA polymerase III transcriptional preinitiation complex formation; RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly; RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly; RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
mitochondrial tRNA wobble uridine modification (GO:0070899)
Namespace: biological_process
Definition: The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified.
mitochondrial tRNA modification (GO:0070900)
Namespace: biological_process
Definition: The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically.
mitochondrial tRNA methylation (GO:0070901)
Namespace: biological_process
Definition: The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.
mitochondrial tRNA thio-modification (GO:0070903)
Namespace: biological_process
Definition: The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule.
obsolete transepithelial L-ascorbic acid transport (GO:0070904)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of L-ascorbic acid from one side of an epithelium to the other.
Synonyms: transepithelial L-ascorbate transport; transepithelial vitamin C transport
Comment: This term was obsoleted because it represents a combination of a process and an anatomical entity.
serine binding (GO:0070905)
Namespace: molecular_function
Definition: Binding to 2-amino-3-hydroxypropanoic acid.
Synonyms: Ser binding
aspartate:alanine antiporter activity (GO:0070906)
Namespace: molecular_function
Definition: Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out).
Synonyms: aspartate-alanine antiporter activity; aspartate/alanine antiporter activity
tyrosine:tyramine antiporter activity (GO:0070908)
Namespace: molecular_function
Definition: Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out).
Synonyms: tyrosine-tyramine antiporter activity; tyrosine/tyramine antiporter activity
glutamate:gamma-aminobutyric acid antiporter activity (GO:0070909)
Namespace: molecular_function
Definition: Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out).
Synonyms: glutamate-gamma-aminobutyric acid antiporter activity; glutamate/gamma-aminobutyric acid antiporter activity; glutamate: GABA antiporter activity
obsolete cell wall macromolecule catabolic process involved in cell wall disassembly (GO:0070910)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
global genome nucleotide-excision repair (GO:0070911)
Namespace: biological_process
Definition: The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome.
Synonyms: GG-NER; GGR; global genome NER; global genomic nucleotide-excision repair; global genomic repair
Ddb1-Ckn1 complex (GO:0070912)
Namespace: cellular_component
Definition: A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.
Ddb1-Wdr21 complex (GO:0070913)
Namespace: cellular_component
Definition: A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.
lysophosphatidic acid receptor activity (GO:0070915)
Namespace: molecular_function
Definition: Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein.
Synonyms: LPA receptor activity
inositol phosphoceramide synthase complex (GO:0070916)
Namespace: cellular_component
Definition: A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces).
Synonyms: IPC synthase complex
inositol phosphoceramide synthase regulator activity (GO:0070917)
Namespace: molecular_function
Definition: Binds to and modulates the activity of inositol phosphoceramide synthase.
Synonyms: IPC synthase regulator activity
Comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
regulatory ncRNA processing (GO:0070918)
Namespace: biological_process
Definition: A process leading to the generation of a functional regulatory non-coding RNA.
Synonyms: gene silencing by RNA, production of guide RNA; gene silencing by RNA, production of small RNA; primary sncRNA processing; production of small RNA involved in gene silencing by RNA; small regulatory ncRNA maturation; small regulatory ncRNA processing; sncRNA processing; sncRNA production
regulation of regulatory ncRNA processing (GO:0070920)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing.
Synonyms: regulation of gene silencing by RNA, production of guide RNA; regulation of gene silencing by RNA, production of small RNA; regulation of production of small RNA involved in gene silencing by RNA
regulation of siRNA processing (GO:0070921)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of siRNA processing.
Synonyms: regulation of chromatin silencing by small RNA, production of siRNA; regulation of production of siRNA involved in chromatin silencing by small RNA; regulation of production of siRNA involved in gene silencing by small RNA; regulation of production of siRNA involved in post-transcriptional gene silencing by RNA; regulation of production of siRNA involved in PTGS; regulation of production of siRNA involved in RNA interference; regulation of RNA interference, production of siRNA; regulation of siRNA production
RISC complex assembly (GO:0070922)
Namespace: biological_process
Definition: The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing complement complex that mediates gene silencing by small RNA.
Synonyms: gene silencing by RNA, small RNA loading onto RISC; miRISC assembly; miRNA loading onto RISC; RISC assembly; siRNA loading onto RISC involved in gene silencing by small RNA; siRNA loading onto RISC involved in RNA interference; small RNA loading onto RISC
organelle assembly (GO:0070925)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
obsolete regulation of ATP:ADP antiporter activity (GO:0070926)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activity of an ATP:ADP antiporter.
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of ATP:ADP antiporter activity (GO:0070927)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops or reduces the activity of an ATP:ADP antiporter.
Synonyms: down regulation of ATP:ADP antiporter activity; down-regulation of ATP:ADP antiporter activity; downregulation of ATP:ADP antiporter activity; inhibition of ATP:ADP antiporter activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete regulation of mRNA stability, ncRNA-mediated (GO:0070928)
Namespace: biological_process
Definition: OBSOLETE. Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
Synonyms: ncRNA-mediated regulation of mRNA stability; regulation of mRNA stability, non-coding RNA-mediated
Comment: This term was obsoleted because it represents the same process as regulatory ncRNA-mediated post-transcriptional gene silencing ; GO:0035194.
trans-translation (GO:0070929)
Namespace: biological_process
Definition: A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes.
trans-translation-dependent protein tagging (GO:0070930)
Namespace: biological_process
Definition: A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation.
Synonyms: co-translational protein tagging; cotranslational protein tagging; protein modification by trans-translation
Comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus.
Golgi-associated vesicle lumen (GO:0070931)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of a Golgi-associated vesicle.
obsolete histone H3 deacetylation (GO:0070932)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the removal of one or more acetyl groups.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H4 deacetylation (GO:0070933)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by the removal of one or more acetyl groups.
Comment: This term was obsoleted because it represents a molecular function.
CRD-mediated mRNA stabilization (GO:0070934)
Namespace: biological_process
Definition: An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD).
Synonyms: coding region determinant-mediated mRNA stabilization
3'-UTR-mediated mRNA stabilization (GO:0070935)
Namespace: biological_process
Definition: An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
Synonyms: 3'-untranslated region-mediated mRNA stabilization
protein K48-linked ubiquitination (GO:0070936)
Namespace: biological_process
Definition: A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
Synonyms: protein K48-linked polyubiquitination
CRD-mediated mRNA stability complex (GO:0070937)
Namespace: cellular_component
Definition: A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9.
Synonyms: coding-region determinant of instability-mediated mRNA stability complex; coding-region instability determinant -mediated mRNA stability complex
Comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
contractile ring (GO:0070938)
Namespace: cellular_component
Definition: A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles.
Synonyms: constriction ring; cytokinetic ring
eisosome assembly (GO:0070941)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane.
neutrophil mediated cytotoxicity (GO:0070942)
Namespace: biological_process
Definition: The directed killing of a target cell by a neutrophil.
Synonyms: neutrophil mediated cell killing
neutrophil-mediated killing of symbiont cell (GO:0070943)
Namespace: biological_process
Definition: The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
Synonyms: neutrophil mediated killing of symbiont cell
neutrophil-mediated killing of bacterium (GO:0070944)
Namespace: biological_process
Definition: The directed killing of a bacterium by a neutrophil.
Synonyms: neutrophil mediated killing of bacterium
neutrophil-mediated killing of gram-negative bacterium (GO:0070945)
Namespace: biological_process
Definition: The directed killing of a gram-negative bacterium by a neutrophil.
Synonyms: neutrophil mediated killing of gram-negative bacterium
neutrophil-mediated killing of gram-positive bacterium (GO:0070946)
Namespace: biological_process
Definition: The directed killing of a gram-positive bacterium by a neutrophil.
Synonyms: neutrophil mediated killing of gram-positive bacterium
neutrophil-mediated killing of fungus (GO:0070947)
Namespace: biological_process
Definition: The directed killing of a fungal cell by a neutrophil.
Synonyms: neutrophil mediated killing of fungus
regulation of neutrophil mediated cytotoxicity (GO:0070948)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil.
Synonyms: regulation of neutrophil mediated cell killing
regulation of neutrophil mediated killing of symbiont cell (GO:0070949)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil.
regulation of neutrophil mediated killing of gram-negative bacterium (GO:0070951)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil.
regulation of neutrophil mediated killing of gram-positive bacterium (GO:0070952)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil.
negative regulation of neutrophil mediated cytotoxicity (GO:0070954)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil.
Synonyms: down regulation of neutrophil mediated cytotoxicity; down-regulation of neutrophil mediated cytotoxicity; downregulation of neutrophil mediated cytotoxicity; inhibition of neutrophil mediated cytotoxicity; negative regulation of neutrophil mediated cell killing
negative regulation of neutrophil mediated killing of symbiont cell (GO:0070955)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil.
Synonyms: down regulation of neutrophil mediated killing of symbiont cell; down-regulation of neutrophil mediated killing of symbiont cell; downregulation of neutrophil mediated killing of symbiont cell; inhibition of neutrophil mediated killing of symbiont cell