LiteFold/GO huggingface dataset:
RNA transport (GO:0050658)
Namespace: biological_process
Definition: The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity (GO:0050659)
Namespace: molecular_function
Definition: Catalysis of the reactions: n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H+, and n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H+.
Synonyms: 3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity; GalNAc4S-6ST; N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity
flavin adenine dinucleotide binding (GO:0050660)
Namespace: molecular_function
Definition: Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
Synonyms: FAD or FADH2 binding; flavine-adenine dinucleotide binding
NADP binding (GO:0050661)
Namespace: molecular_function
Definition: Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
Synonyms: NADP or NADPH binding; NADP+ or NADPH binding; nicotinamide adenine dinucleotide phosphate binding
obsolete coenzyme binding (GO:0050662)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
Comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a coenzyme.
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor (GO:0050664)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule.
Synonyms: oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
hydrogen peroxide biosynthetic process (GO:0050665)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms: H2O2 biosynthetic process; hydrogen peroxide anabolism; hydrogen peroxide biosynthesis; hydrogen peroxide formation; hydrogen peroxide generation; hydrogen peroxide synthesis
obsolete regulation of homocysteine metabolic process (GO:0050666)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.
Synonyms: regulation of Hcy metabolic process; regulation of Hcy metabolism; regulation of homocysteine metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
homocysteine metabolic process (GO:0050667)
Namespace: biological_process
Definition: The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
Synonyms: Hcy metabolic process; Hcy metabolism; homocysteine metabolism
obsolete positive regulation of homocysteine metabolic process (GO:0050668)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.
Synonyms: activation of homocysteine metabolic process; positive regulation of Hcy metabolic process; positive regulation of Hcy metabolism; positive regulation of homocysteine metabolism; stimulation of homocysteine metabolic process; up regulation of homocysteine metabolic process; up-regulation of homocysteine metabolic process; upregulation of homocysteine metabolic process
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete negative regulation of homocysteine metabolic process (GO:0050669)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.
Synonyms: down regulation of homocysteine metabolic process; down-regulation of homocysteine metabolic process; downregulation of homocysteine metabolic process; inhibition of homocysteine metabolic process; negative regulation of Hcy metabolic process; negative regulation of Hcy metabolism; negative regulation of homocysteine metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
regulation of lymphocyte proliferation (GO:0050670)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of lymphocyte proliferation.
positive regulation of lymphocyte proliferation (GO:0050671)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of lymphocyte proliferation.
Synonyms: activation of lymphocyte proliferation; stimulation of lymphocyte proliferation; up regulation of lymphocyte proliferation; up-regulation of lymphocyte proliferation; upregulation of lymphocyte proliferation
negative regulation of lymphocyte proliferation (GO:0050672)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.
Synonyms: down regulation of lymphocyte proliferation; down-regulation of lymphocyte proliferation; downregulation of lymphocyte proliferation; inhibition of lymphocyte proliferation
epithelial cell proliferation (GO:0050673)
Namespace: biological_process
Definition: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
urothelial cell proliferation (GO:0050674)
Namespace: biological_process
Definition: The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria.
regulation of urothelial cell proliferation (GO:0050675)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of urothelial cell proliferation.
negative regulation of urothelial cell proliferation (GO:0050676)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation.
Synonyms: down regulation of urothelial cell proliferation; down-regulation of urothelial cell proliferation; downregulation of urothelial cell proliferation; inhibition of urothelial cell proliferation
positive regulation of urothelial cell proliferation (GO:0050677)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of urothelial cell proliferation.
Synonyms: activation of urothelial cell proliferation; stimulation of urothelial cell proliferation; up regulation of urothelial cell proliferation; up-regulation of urothelial cell proliferation; upregulation of urothelial cell proliferation
regulation of epithelial cell proliferation (GO:0050678)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
positive regulation of epithelial cell proliferation (GO:0050679)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of epithelial cell proliferation.
Synonyms: activation of epithelial cell proliferation; stimulation of epithelial cell proliferation; up regulation of epithelial cell proliferation; up-regulation of epithelial cell proliferation; upregulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation (GO:0050680)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
Synonyms: down regulation of epithelial cell proliferation; down-regulation of epithelial cell proliferation; downregulation of epithelial cell proliferation; inhibition of epithelial cell proliferation
nuclear androgen receptor binding (GO:0050681)
Namespace: molecular_function
Definition: Binding to a nuclear androgen receptor.
Synonyms: androgen receptor binding; AR binding
AF-2 domain binding (GO:0050682)
Namespace: molecular_function
Definition: Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.
AF-1 domain binding (GO:0050683)
Namespace: molecular_function
Definition: Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.
regulation of mRNA processing (GO:0050684)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
positive regulation of mRNA processing (GO:0050685)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mRNA processing.
Synonyms: activation of mRNA processing; stimulation of mRNA processing; up regulation of mRNA processing; up-regulation of mRNA processing; upregulation of mRNA processing
negative regulation of mRNA processing (GO:0050686)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing.
Synonyms: down regulation of mRNA processing; down-regulation of mRNA processing; downregulation of mRNA processing; inhibition of mRNA processing
negative regulation of defense response to virus (GO:0050687)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.
Synonyms: down regulation of antiviral response; down-regulation of antiviral response; downregulation of antiviral response; inhibition of antiviral response; negative regulation of antiviral response
regulation of defense response to virus (GO:0050688)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
Synonyms: regulation of antiviral response
regulation of defense response to virus by host (GO:0050691)
Namespace: biological_process
Definition: Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.
Synonyms: host regulation of antiviral response; regulation by host of antiviral response; regulation of antiviral response by host
DNA binding domain binding (GO:0050692)
Namespace: molecular_function
Definition: Binding to a protein's DNA binding domain (DBD).
Synonyms: DBD binding
galactose 3-O-sulfotransferase activity (GO:0050694)
Namespace: molecular_function
Definition: Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc.
Synonyms: Gal-3-O-sulfotransferase activity; galactose 3-O-sulphotransferase activity
benzoylformate decarboxylase activity (GO:0050695)
Namespace: molecular_function
Definition: Catalysis of the reaction: benzoylformate = benzaldehyde + CO2.
Synonyms: benzoylformate carboxy-lyase (benzaldehyde-forming); benzoylformate carboxy-lyase activity; phenylglyoxylate decarboxylase activity
trichloroethylene catabolic process (GO:0050696)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent.
Synonyms: trichloroethene catabolic process; trichloroethene catabolism; trichloroethylene breakdown; trichloroethylene catabolism; trichloroethylene degradation
trichloroethene reductive dehalogenase activity (GO:0050697)
Namespace: molecular_function
Definition: Catalysis of the reaction: AH2 + trichloroethene = (Z)-1,2-dichloroethene + A + chloride + H+.
Synonyms: 1,1,2-trichloroethene reductive dehalogenase activity; 1,1,2-trichloroethylene reductive dehalogenase activity; TCE-reductive dehalogenase activity
proteoglycan sulfotransferase activity (GO:0050698)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans.
Synonyms: proteoglycan sulfate transfer; proteoglycan sulphotransferase activity
WW domain binding (GO:0050699)
Namespace: molecular_function
Definition: Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
CARD domain binding (GO:0050700)
Namespace: molecular_function
Definition: Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
regulation of protein secretion (GO:0050708)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
negative regulation of protein secretion (GO:0050709)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
Synonyms: down regulation of protein secretion; down-regulation of protein secretion; downregulation of protein secretion; inhibition of protein secretion
positive regulation of protein secretion (GO:0050714)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
Synonyms: activation of protein secretion; stimulation of protein secretion; up regulation of protein secretion; up-regulation of protein secretion; upregulation of protein secretion
regulation of inflammatory response (GO:0050727)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
negative regulation of inflammatory response (GO:0050728)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
Synonyms: anti-inflammatory response; down regulation of inflammatory response; down-regulation of inflammatory response; downregulation of inflammatory response; inhibition of inflammatory response
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
Synonyms: activation of peptidyl-tyrosine phosphorylation; stimulation of peptidyl-tyrosine phosphorylation; up regulation of peptidyl-tyrosine phosphorylation; up-regulation of peptidyl-tyrosine phosphorylation; upregulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
Synonyms: down regulation of peptidyl-tyrosine phosphorylation; down-regulation of peptidyl-tyrosine phosphorylation; downregulation of peptidyl-tyrosine phosphorylation; inhibition of peptidyl-tyrosine phosphorylation
RS domain binding (GO:0050733)
Namespace: molecular_function
Definition: Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.
N-malonyltransferase activity (GO:0050735)
Namespace: molecular_function
Definition: Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule.
O-malonyltransferase activity (GO:0050736)
Namespace: molecular_function
Definition: Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule.
O-hydroxycinnamoyltransferase activity (GO:0050737)
Namespace: molecular_function
Definition: Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule.
fructosyltransferase activity (GO:0050738)
Namespace: molecular_function
Definition: Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
obsolete peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium (GO:0050739)
Namespace: biological_process
Definition: OBSOLETE. The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium.
Comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
obsolete protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine (GO:0050740)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine.
Comment: This is a molecular function.
obsolete protein-FMN linkage via O3-riboflavin phosphoryl-L-serine (GO:0050741)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine.
Comment: This is a molecular function.
obsolete protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine (GO:0050743)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine.
Comment: This is a molecular function.
obsolete protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine (GO:0050744)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine.
Comment: This is a molecular function.
regulation of lipoprotein metabolic process (GO:0050746)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.
Synonyms: regulation of lipoprotein metabolism
positive regulation of lipoprotein metabolic process (GO:0050747)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.
Synonyms: activation of lipoprotein metabolic process; positive regulation of lipoprotein metabolism; stimulation of lipoprotein metabolic process; up regulation of lipoprotein metabolic process; up-regulation of lipoprotein metabolic process; upregulation of lipoprotein metabolic process
negative regulation of lipoprotein metabolic process (GO:0050748)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.
Synonyms: down regulation of lipoprotein metabolic process; down-regulation of lipoprotein metabolic process; downregulation of lipoprotein metabolic process; inhibition of lipoprotein metabolic process; negative regulation of lipoprotein metabolism
obsolete apolipoprotein E receptor binding (GO:0050749)
Namespace: molecular_function
Definition: OBSOLETE. Interacting selectively with an apolipoprotein E receptor.
Synonyms: apolipoprotein E receptor binding
Comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
low-density lipoprotein particle receptor binding (GO:0050750)
Namespace: molecular_function
Definition: Binding to a low-density lipoprotein receptor.
Synonyms: LDL receptor binding; low-density lipoprotein receptor binding
obsolete thymidylate synthase biosynthetic process (GO:0050757)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Synonyms: thymidylate synthase anabolism; thymidylate synthase biosynthesis; thymidylate synthase formation; thymidylate synthase synthesis
Comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'regulation of gene expression', 'regulation of transcription' or some signaling term.
obsolete regulation of thymidylate synthase biosynthetic process (GO:0050758)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase.
Synonyms: regulation of thymidylate synthase anabolism; regulation of thymidylate synthase biosynthesis; regulation of thymidylate synthase formation; regulation of thymidylate synthase synthesis
Comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'regulation of gene expression', 'regulation of transcription' or some signaling term.