LiteFold/GO huggingface dataset:
spiracle morphogenesis, open tracheal system (GO:0035277)
Namespace: biological_process
Definition: The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.
Synonyms: spiracle morphogenesis
miRNA-mediated gene silencing by inhibition of translation (GO:0035278)
Namespace: biological_process
Definition: An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.
Synonyms: down regulation of translation involved in gene silencing by miRNA; down-regulation of translation involved in gene silencing by miRNA; downregulation of translation involved in gene silencing by miRNA; gene silencing by miRNA, negative regulation of translation; inhibition of translation involved in gene silencing by miRNA; miRNA mediated inhibition of translation; miRNA-mediated gene silencing, negative regulation of translation; negative regulation of translation involved in gene silencing by microRNA
miRNA-mediated gene silencing by mRNA destabilization (GO:0035279)
Namespace: biological_process
Definition: An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.
Synonyms: deadenylation involved in gene silencing by miRNA; gene silencing by miRNA, mRNA cleavage; gene silencing by mRNA cleavage; miRNA-mediated gene silencing by mRNA deadenylation; miRNA-mediated gene silencing, mRNA cleavage; mRNA cleavage involved in gene silencing by microRNA; mRNA cleavage involved in gene silencing by miRNA; mRNA deadenylation-mediated gene silencing by miRNA; mRNA destabilization-mediated gene silencing by miRNA
segmentation (GO:0035282)
Namespace: biological_process
Definition: The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.
central nervous system segmentation (GO:0035283)
Namespace: biological_process
Definition: Division of the central nervous system into a series of semi-repetitive parts or segments.
brain segmentation (GO:0035284)
Namespace: biological_process
Definition: Division of the brain into a series of semi-repetitive parts or segments.
appendage segmentation (GO:0035285)
Namespace: biological_process
Definition: Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented.
obsolete leg segmentation (GO:0035286)
Namespace: biological_process
Definition: OBSOLETE. Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint.
Synonyms: leg segmentation
Comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying.
anterior head segmentation (GO:0035288)
Namespace: biological_process
Definition: Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments.
Synonyms: procephalic segmentation
Comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children.
posterior head segmentation (GO:0035289)
Namespace: biological_process
Definition: Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains.
Synonyms: gnathal segmentation
Comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children.
trunk segmentation (GO:0035290)
Namespace: biological_process
Definition: Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.
specification of segmental identity, intercalary segment (GO:0035291)
Namespace: biological_process
Definition: The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
Comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'.
specification of segmental identity, trunk (GO:0035292)
Namespace: biological_process
Definition: The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
chitin-based larval cuticle pattern formation (GO:0035293)
Namespace: biological_process
Definition: The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster.
determination of wing disc primordium (GO:0035294)
Namespace: biological_process
Definition: Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc.
tube development (GO:0035295)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
regulation of tube diameter (GO:0035296)
Namespace: biological_process
Definition: Any process that modulates the diameter of a tube.
regulation of Malpighian tubule diameter (GO:0035297)
Namespace: biological_process
Definition: Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producing tubes with a cirumference of two cells.
regulation of Malpighian tubule size (GO:0035298)
Namespace: biological_process
Definition: Ensuring that a Malpighian tubule is the correct length and diameter.
inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity (GO:0035299)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H+.
Synonyms: inositol hexakisphosphate synthase; inositol pentakisphosphate 2-kinase activity; inositol polyphosphate kinase activity; inositol-pentakisphosphate 2-kinase activity; Ins(1,3,4,5,6)P5 2-kinase activity; IP5 2-kinase activity
obsolete inositol-1,3,4-trisphosphate 5/6-kinase activity (GO:0035300)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.
Synonyms: inositol 1,3,4-trisphosphate 5-kinase activity; inositol 1,3,4-trisphosphate 6-kinase activity; inositol-1,3,4-trisphosphate 5/6-kinase activity
Comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
Hedgehog signaling complex (GO:0035301)
Namespace: cellular_component
Definition: A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila).
Synonyms: Hedgehog signalling complex; HSC
ecdysteroid 25-hydroxylase activity (GO:0035302)
Namespace: molecular_function
Definition: Catalysis of the hydroxylation of an ecdysteroid at carbon position 25.
Comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol).
regulation of dephosphorylation (GO:0035303)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule.
obsolete regulation of protein dephosphorylation (GO:0035304)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein.
Synonyms: regulation of protein amino acid dephosphorylation
Comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
negative regulation of dephosphorylation (GO:0035305)
Namespace: biological_process
Definition: Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.
Synonyms: down regulation of dephosphorylation; down-regulation of dephosphorylation; downregulation of dephosphorylation; inhibition of dephosphorylation
positive regulation of dephosphorylation (GO:0035306)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule.
Synonyms: activation of dephosphorylation; stimulation of dephosphorylation; up regulation of dephosphorylation; up-regulation of dephosphorylation; upregulation of dephosphorylation
obsolete positive regulation of protein dephosphorylation (GO:0035307)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.
Synonyms: activation of protein amino acid dephosphorylation; positive regulation of protein amino acid dephosphorylation; stimulation of protein amino acid dephosphorylation; up regulation of protein amino acid dephosphorylation; up-regulation of protein amino acid dephosphorylation; upregulation of protein amino acid dephosphorylation
Comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
obsolete negative regulation of protein dephosphorylation (GO:0035308)
Namespace: biological_process
Definition: OBSOLETE. Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.
Synonyms: down regulation of protein amino acid dephosphorylation; down-regulation of protein amino acid dephosphorylation; downregulation of protein amino acid dephosphorylation; inhibition of protein amino acid dephosphorylation; negative regulation of protein amino acid dephosphorylation
Comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
wing and notum subfield formation (GO:0035309)
Namespace: biological_process
Definition: The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures.
notum cell fate specification (GO:0035310)
Namespace: biological_process
Definition: The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment.
5'-3' DNA exonuclease activity (GO:0035312)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.
Synonyms: 5'-3' exodeoxyribonuclease activity
wound healing, spreading of epidermal cells (GO:0035313)
Namespace: biological_process
Definition: The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.
scab formation (GO:0035314)
Namespace: biological_process
Definition: Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection.
hair cell differentiation (GO:0035315)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a hair cell.
non-sensory hair organization (GO:0035316)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis.
Synonyms: non-sensory hair organization and biogenesis; trichome organisation; trichome organization and biogenesis
Comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'.
imaginal disc-derived wing hair organization (GO:0035317)
Namespace: biological_process
Definition: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
Synonyms: imaginal disc-derived wing hair organization and biogenesis; wing hair organisation; wing hair organization and biogenesis; wing trichome organization and biogenesis
Comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'.
imaginal disc-derived wing hair elongation (GO:0035319)
Namespace: biological_process
Definition: Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles.
Synonyms: wing hair elongation; wing prehair extension
imaginal disc-derived wing hair site selection (GO:0035320)
Namespace: biological_process
Definition: Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally.
Synonyms: prehair localization; wing hair site selection
maintenance of imaginal disc-derived wing hair orientation (GO:0035321)
Namespace: biological_process
Definition: Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity.
Synonyms: maintenance of wing hair orientation
obsolete mesenchymal cell migration involved in limb bud formation (GO:0035322)
Namespace: biological_process
Definition: OBSOLETE. The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
male germline ring canal (GO:0035323)
Namespace: cellular_component
Definition: An intercellular bridge that connects the germline cells of a male cyst.
Synonyms: spermatocyte ring canal; testicular ring canal
female germline ring canal (GO:0035324)
Namespace: cellular_component
Definition: An intercellular bridge that connects the germline cells of a female cyst.
Synonyms: nurse cell ring canal; ovarian ring canal
Toll-like receptor binding (GO:0035325)
Namespace: molecular_function
Definition: Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms: TLR binding
hippo signaling (GO:0035329)
Namespace: biological_process
Definition: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
Synonyms: hippo signal transduction; hippo signaling cascade; hippo signaling pathway; hippo signalling cascade; Salvador-Warts-Hippo signaling pathway; SWH pathway
regulation of hippo signaling (GO:0035330)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of hippo signaling.
Synonyms: regulation of hippo signaling cascade; regulation of hippo signaling pathway; regulation of hippo signalling cascade
negative regulation of hippo signaling (GO:0035331)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
Synonyms: negative regulation of hippo signaling cascade; negative regulation of hippo signaling pathway; negative regulation of hippo signalling cascade
positive regulation of hippo signaling (GO:0035332)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of hippo signaling.
Synonyms: positive regulation of hippo signaling cascade; positive regulation of hippo signaling pathway; positive regulation of hippo signalling cascade
Notch receptor processing, ligand-dependent (GO:0035333)
Namespace: biological_process
Definition: The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
Synonyms: Notch S2 cleavage; Notch S3 cleavage
Notch receptor processing, ligand-independent (GO:0035334)
Namespace: biological_process
Definition: The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.
Synonyms: Notch S1 cleavage
peptidyl-tyrosine dephosphorylation (GO:0035335)
Namespace: biological_process
Definition: The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
long-chain fatty-acyl-CoA metabolic process (GO:0035336)
Namespace: biological_process
Definition: The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Synonyms: long-chain fatty acyl CoA metabolic process; long-chain fatty acyl-CoA metabolism
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
fatty-acyl-CoA metabolic process (GO:0035337)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.
Synonyms: fatty acyl CoA metabolic process; fatty-acyl-CoA metabolism
obsolete SPOTS complex (GO:0035339)
Namespace: cellular_component
Definition: OBSOLETE. A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
Synonyms: serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex
Comment: The reason for obsoletion is that this term is equivalent to serine C-palmitoyltransferase complex.
inosine transport (GO:0035340)
Namespace: biological_process
Definition: The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: hypoxanthine riboside transport
regulation of inosine transport (GO:0035341)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: regulation of hypoxanthine riboside transport
positive regulation of inosine transport (GO:0035342)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: positive regulation of hypoxanthine riboside transport
hypoxanthine transport (GO:0035344)
Namespace: biological_process
Definition: The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: 6-hydroxypurine transport; hypoxanthine transmembrane transport
regulation of hypoxanthine transport (GO:0035345)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: regulation of 6-hydroxypurine transport
positive regulation of hypoxanthine transport (GO:0035346)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: positive regulation of 6-hydroxypurine transport
negative regulation of hypoxanthine transport (GO:0035347)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: negative regulation of 6-hydroxypurine transport
acetyl-CoA transmembrane transport (GO:0035348)
Namespace: biological_process
Definition: The process in which acetyl-CoA is transported across a membrane. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms: acetyl-CoA membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.