LiteFold/GO huggingface dataset:
L-tryptophan decarboxylase activity (GO:0036469)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine.
tyrosine 3-monooxygenase activator activity (GO:0036470)
Namespace: molecular_function
Definition: Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase).
Synonyms: TH activator activity; tyrosine hydroxylase activator activity
cellular response to glyoxal (GO:0036471)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus.
obsolete cell death in response to oxidative stress (GO:0036473)
Namespace: biological_process
Definition: OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus.
Comment: The reason for obsoletion is that this term represent an assay or a phenotype.
obsolete cell death in response to hydrogen peroxide (GO:0036474)
Namespace: biological_process
Definition: OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2).
Synonyms: cell death in response to H2O2; hydrogen peroxide-mediated cell death
Comment: The reason for obsoletion is that this term represent an assay or a phenotype.
obsolete neuron death in response to oxidative stress (GO:0036475)
Namespace: biological_process
Definition: OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus.
Synonyms: neuronal cell death in response to oxidative stress; oxidative stress-induced neuron death
Comment: The reason for obsoletion is that this term often represents an assay, or a phenotype and not a GO process.
somatodendritic compartment (GO:0036477)
Namespace: cellular_component
Definition: The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
L-dopa decarboxylase activator activity (GO:0036478)
Namespace: molecular_function
Definition: Interacts with and increases L-dopa decarboxylase activity.
Synonyms: DDC activator activity
Comment: GO:0036478 is reserved for cases when the activator directly interacts with L-dopa decarboxylase. When activation of L-dopa decarboxylase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'positive regulation of L-dopa decarboxylase activity ; GO:1903200'.
peroxidase inhibitor activity (GO:0036479)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of peroxidase.
Comment: GO:0036479 is reserved for cases when the inhibitor directly interacts with the peroxidase. When inhibition of peroxidase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'negative regulation of peroxidase activity ; GO:2000469'.
neuron intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0036480)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
Synonyms: neuron apoptosis in response to oxidative stress; oxidative stress-induced neuron apoptosis; oxidative stress-induced neuronal apoptosis
intrinsic apoptotic signaling pathway in response to hydrogen peroxide (GO:0036481)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).
Synonyms: H2O2-induced intrinsic apoptotic signaling pathway; hydrogen peroxide-induced apoptosis; hydrogen peroxide-induced intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to H2O2
neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide (GO:0036482)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide.
Synonyms: H2O2-induced neuron intrinsic apoptotic signaling pathway; hydrogen peroxide-induced neuron apoptosis; hydrogen peroxide-induced neuronal apoptosis; neuron apoptosis in response to hydrogen peroxide; neuron intrinsic apoptotic signaling pathway in response to H2O2
neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0036483)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Synonyms: endoplasmic reticulum stress-induced neuron apoptosis; endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; ER stress-induced neuron apoptosis; ER stress-induced neuron intrinsic apoptotic signaling pathway
trunk neural crest cell migration (GO:0036484)
Namespace: biological_process
Definition: The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.
Synonyms: trunk NCC migration
dorsolateral trunk neural crest cell migration (GO:0036485)
Namespace: biological_process
Definition: The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells.
Synonyms: dorsolateral trunk NCC migration
ventral trunk neural crest cell migration (GO:0036486)
Namespace: biological_process
Definition: The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.
Synonyms: trunk NCC migration through anterior sclerotome; trunk NCC migration within somite; ventral trunk NCC migration
nitric-oxide synthase inhibitor activity (GO:0036487)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of nitric oxide synthase.
Synonyms: nitric oxide synthase inhibitor activity; NOS inhibitor activity
neuromelanin biosynthetic process (GO:0036489)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers.
Synonyms: neuromelanin anabolism; neuromelanin biosynthesis; neuromelanin formation; neuromelanin synthesis
regulation of translation in response to endoplasmic reticulum stress (GO:0036490)
Namespace: biological_process
Definition: Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.
Synonyms: regulation of translation in response to ER stress
regulation of translation initiation in response to endoplasmic reticulum stress (GO:0036491)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress.
Synonyms: regulation of translation initiation in response to ER stress
eiF2alpha phosphorylation in response to endoplasmic reticulum stress (GO:0036492)
Namespace: biological_process
Definition: The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.
Synonyms: eiF2alpha phosphorylation in response to ER stress; regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress
positive regulation of translation in response to endoplasmic reticulum stress (GO:0036493)
Namespace: biological_process
Definition: Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.
Synonyms: positive regulation of translation in response to ER stress
positive regulation of translation initiation in response to endoplasmic reticulum stress (GO:0036494)
Namespace: biological_process
Definition: Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.
Synonyms: positive regulation of translation initiation in response to ER stress
negative regulation of translation initiation in response to endoplasmic reticulum stress (GO:0036495)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.
Synonyms: negative regulation of translation initiation in response to ER stress
regulation of translational initiation by eIF2 alpha dephosphorylation (GO:0036496)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha.
eIF2alpha dephosphorylation in response to endoplasmic reticulum stress (GO:0036497)
Namespace: biological_process
Definition: The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.
Synonyms: eIF2alpha dephosphorylation in response to ER stress; regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
IRE1-mediated unfolded protein response (GO:0036498)
Namespace: biological_process
Definition: The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Synonyms: endoplasmic reticulum unfolded protein response; IRE1 signaling; ERN1-mediated unfolded protein response; inositol-requiring enzyme 1-mediated unfolded protein response; inositol-requiring transmembrane kinase/endonuclease signal transduction; IRE1 branch of UPR; IRE1 signal transduction pathway; IRE1 signaling in response to endoplasmic reticulum stress; IRE1alpha unfolded protein response; IRE1p unfolded protein response; UPR signaling by IRE1 stress sensor
Comment: Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
PERK-mediated unfolded protein response (GO:0036499)
Namespace: biological_process
Definition: The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
Synonyms: EIF2AK3-mediated unfolded protein response; endoplasmic reticulum unfolded protein response; PERK signaling; eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response; PERK branch of UPR; PERK signal transduction pathway; PERK signaling in response to endoplasmic reticulum stress; PKR-like ER kinase signal transduction; UPR signaling by PERK stress sensor
ATF6-mediated unfolded protein response (GO:0036500)
Namespace: biological_process
Definition: The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
Synonyms: activating transcription factor 6 signaling in unfolded protein response; ATF6 branch of UPR; ATF6 signal transduction pathway; ATF6 signaling in response to endoplasmic reticulum stress; ATF6-alpha UPR branch; ATF6-beta UPR branch; endoplasmic reticulum unfolded protein response; ATF6 signaling; UPR signaling by ATF6 stress sensor
UFD1-NPL4 complex (GO:0036501)
Namespace: cellular_component
Definition: A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p.
Synonyms: Npl4p-Ufd1p complex; Ufd1-Npl4 binary complex; Ufd1-Npl4 cofactor complex; Ufd1/Npl4 complex; UFD1L-NPLOC4 complex
Derlin-1-VIMP complex (GO:0036502)
Namespace: cellular_component
Definition: A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome.
Synonyms: Derlin-1/VIMP complex
ERAD pathway (GO:0036503)
Namespace: biological_process
Definition: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Synonyms: endoplasmic reticulum-associated degradation; endoplasmic reticulum-associated protein degradation pathway; ER-associated degradation pathway; protein degradation by ERAD
Comment: ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
Golgi membrane fusion (GO:0036504)
Namespace: biological_process
Definition: The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.
Synonyms: Golgi apparatus membrane fusion; membrane fusion involved in Golgi reassembly; post-mitotic fusion of Golgi membranes
prosaposin receptor activity (GO:0036505)
Namespace: molecular_function
Definition: Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D).
Synonyms: prosaposin-activated receptor activity
maintenance of unfolded protein (GO:0036506)
Namespace: biological_process
Definition: Maintaining a protein in an unfolded, soluble state.
protein alpha-1,2-demannosylation (GO:0036508)
Namespace: biological_process
Definition: The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein.
Synonyms: glycoprotein mannose trimming; mannose trimming
Comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'.
obsolete trimming of terminal mannose on B branch (GO:0036509)
Namespace: biological_process
Definition: OBSOLETE. The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
Synonyms: conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2; conversion of M9 to M8B; glycoprotein mannose trimming on B branch
Comment: This term was obsoleted because it represents a molecular function.
obsolete trimming of first mannose on A branch (GO:0036511)
Namespace: biological_process
Definition: OBSOLETE. The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
Synonyms: conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2; conversion of M9 to M8A; glycoprotein mannose trimming on A branch
Comment: This term was obsoleted because it represents a molecular function.
obsolete trimming of second mannose on A branch (GO:0036512)
Namespace: biological_process
Definition: OBSOLETE. The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.
Synonyms: conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2; conversion of M8A to M7AA; glycoprotein mannose trimming on A branch
Comment: This term was obsoleted because it represents a molecular function.
Derlin-1 retrotranslocation complex (GO:0036513)
Namespace: cellular_component
Definition: A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.
Synonyms: Derlin-1 complex; Derlin-1 protein dislocation complex; Derlin-1 retro-translocation complex; Derlin-1 retrotranslocon; ERAD protein dislocation complex
Comment: The Derlin-1 retrotranslocation complex is likely to assemble in steps, thereby containing different components at different stages of the retrotranslocation process.
dopaminergic neuron axon guidance (GO:0036514)
Namespace: biological_process
Definition: The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues.
Synonyms: DA axon guidance; dopaminergic axon guidance; mdDA axon guidance
serotonergic neuron axon guidance (GO:0036515)
Namespace: biological_process
Definition: The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues.
Synonyms: 5-HT axon guidance; serotonergic axon guidance
chemoattraction of dopaminergic neuron axon (GO:0036516)
Namespace: biological_process
Definition: The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.
Synonyms: chemoattraction of DA axon; chemoattraction of dopaminergic axon
chemoattraction of serotonergic neuron axon (GO:0036517)
Namespace: biological_process
Definition: The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.
Synonyms: chemoattraction of 5-HT axon; chemoattraction of serotonergic axon
chemorepulsion of dopaminergic neuron axon (GO:0036518)
Namespace: biological_process
Definition: The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
Synonyms: chemorepulsion of DA axon; chemorepulsion of dopaminergic axon
chemorepulsion of serotonergic neuron axon (GO:0036519)
Namespace: biological_process
Definition: The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.
Synonyms: chemorepulsion of 5-HT axon; chemorepulsion of serotonergic axon
astrocyte-dopaminergic neuron signaling (GO:0036520)
Namespace: biological_process
Definition: Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron.
Synonyms: astrocyte-dopaminergic neuron cell signaling; dopaminergic neuron-astrocyte crosstalk; mesencephalic dopaminergic neuron-astrocyte crosstalk; midbrain dopaminergic neuron-astrocyte crosstalk
obsolete modulation by symbiont of host protein localization to phagocytic vesicle (GO:0036521)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: modulation by symbiont of host protein localisation to phagosome
Comment: This term was obsoleted because it represents an unnecessary grouping class.
symbiont-mediated suppression of host protein localization to phagocytic vesicle (GO:0036522)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the normal localization of a protein to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption of host protein localisation to phagosome; inhibition of host protein localisation to phagosome; negative regulation by symbiont of host protein localization to phagocytic vesicle; suppression of host protein localisation to phagosome
obsolete induction by symbiont of host cytokine production (GO:0036523)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: 'induction by symbiont of host cytokine secretion'; induction by symbiont of host cytokine secretion; positive regulation by symbiont of host cytokine secretion
Comment: This term was obsoleted because it does not represent a real process.
protein deglycase activity (GO:0036524)
Namespace: molecular_function
Definition: Catalysis of the removal of a sugar or dicarbonyl from a glycated L-arginine, L-lysine or L-cysteine residue within proteins that have been attacked and modified by glyoxal or 2-oxopropanal.
Synonyms: glyoxylase III; protein deglycating enzyme
protein deglycation (GO:0036525)
Namespace: biological_process
Definition: The removal of a sugar or dicarbonyl from a glycated protein.
Synonyms: glycated protein repair
Comment: Glycation is a non enzymatic covalent addition of a sugar or dicarbonyl (methylglyoxal, glyoxal) to a protein. Deglycation repairs the glycated amino acids.
peptidyl-cysteine deglycation (GO:0036526)
Namespace: biological_process
Definition: The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein.
Synonyms: deglycation of N-acetylcysteine