LiteFold/GO huggingface dataset:
NAD+-protein-lysine ADP-ribosyltransferase activity (GO:0140804)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide.
NAD+-protein-serine ADP-ribosyltransferase activity (GO:0140805)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].
NAD+-protein-aspartate ADP-ribosyltransferase activity (GO:0140806)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide.
NAD+-protein-glutamate ADP-ribosyltransferase activity (GO:0140807)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide.
NAD+-protein-tyrosine ADP-ribosyltransferase activity (GO:0140808)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein].
histone H1R54 arginine deiminase activity (GO:0140810)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone H1 L-arginyl (position 54)= histone H1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54.
Synonyms: H1-R54 citrullination; histone H1-R54 deiminase activity; histone-arginine deiminase activity (H1-R54 specific)
Comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
orotate:monoatomic anion antiporter activity (GO:0140812)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out).
Synonyms: orotate:anion antiporter activity; orotate:organic anion antiporter activity
urate:monoatomic anion antiporter activity (GO:0140813)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out).
Synonyms: urate:anion antiporter activity; urate:organic anion antiporter activity
glycine betaine:sodium:chloride symporter activity (GO:0140814)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in).
Synonyms: sodium/chloride-dependent glycine betaine transporter activity
NAD+-protein-histidine ADP-ribosyltransferase activity (GO:0140815)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide.
NAD+-histone H2BS6 serine ADP-ribosyltransferase activity (GO:0140816)
Namespace: molecular_function
Definition: Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B.
Synonyms: NAD+-histone H2B-S6 serine ADP-ribosyltransferase activity; NAD+-histone-serine ADP-ribosyltransferase activity (H2B-S6 specific)
Comment: Note that the residue position corresponds to the canonical human H2B histone (UniProtKB:P62807); the N-terminus of histone H2B is divergent across eukaryotes; make sure that the paper clearly references the human protein for the position of this modification to use this term. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
NAD+-histone H3S10 serine ADP-ribosyltransferase activity (GO:0140817)
Namespace: molecular_function
Definition: Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3.
Synonyms: NAD+-histone H3-S10 serine ADP-ribosyltransferase activity; NAD+-histone-serine ADP-ribosyltransferase activity (H3-S10 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
mRNA 5'-triphosphate monophosphatase activity (GO:0140818)
Namespace: molecular_function
Definition: A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate.
Synonyms: mRNA 5'-phosphatase activity
UDP-beta-L-arabinofuranose transporter activity (GO:0140819)
Namespace: molecular_function
Definition: Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other.
cytosol to Golgi apparatus transport (GO:0140820)
Namespace: biological_process
Definition: The directed movement of substances from the cytosol into the Golgi apparatus of a cell.
UDP-beta-L-arabinofuranose import into Golgi lumen (GO:0140821)
Namespace: biological_process
Definition: The directed movement of UDP-beta-L-arabinofuranose from the cytosol to the Golgi apparatus of a cell.
Synonyms: cytosol to Golgi apparatus UDP-beta-L-arabinofuranose transport
NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity (GO:0140822)
Namespace: molecular_function
Definition: Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue).
Synonyms: NAD+-histone H2B-E35 glutamate ADP-ribosyltransferase activity; NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E35 specific)
Comment: Note that the residue position corresponds to the canonical human H2B histone (UniProtKB:P62807); this residue is conserved across all eukaryotes, but seems to be missing from Dictyostelium. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2BS36 kinase activity (GO:0140823)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B.
Synonyms: histone H2B-S36 kinase activity; histone kinase activity (H2B-S36 specific)
Comment: Note that the residue position corresponds to the canonical human H2B histone (UniProtKB:P62807); this residue is conserved across all animals, and is replaced by a Thr in plants and fungi, but seems to be missing from Dictyostelium. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
thioredoxin-dependent peroxiredoxin activity (GO:0140824)
Namespace: molecular_function
Definition: Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O.
lactoperoxidase activity (GO:0140825)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O.
Synonyms: heme peroxidase activity; peroxidase activity
zinc:proton antiporter activity (GO:0140826)
Namespace: molecular_function
Definition: Enables the transfer of zinc from one side of a membrane to the other according to the reaction: H+(out) + Zn2+(in) = H+(in) + Zn2+(out).
Comment: Some transporters exchange 1 H+ for a Zn2+ while others are electroneutral and exchange 2 H+.
zinc chaperone activity (GO:0140827)
Namespace: molecular_function
Definition: Binding to and delivering zinc ions to a target protein.
Synonyms: zinc carrier activity
metal cation:monoatomic cation antiporter activity (GO:0140828)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out).
Synonyms: solute:metal cation antiporter activity
bicarbonate:monoatomic anion antiporter activity (GO:0140829)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in).
Synonyms: bicarbonate:anion antiporter activity; hydrogencarbonate:monoatomic anion antiporter activity
L-glutamine, sodium:proton antiporter activity (GO:0140830)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-glutamine(out) + Na+(out) = H+(out) + L-glutamine(in) + Na+(in).
L-asparagine, sodium:proton antiporter activity (GO:0140831)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in).
L-histidine, sodium:proton antiporter activity (GO:0140832)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-histidine(out) + Na+(out) = H+(out) + L-histidine(in) + Na+(in).
RNA polymerase II CTD heptapeptide repeat Y1 kinase activity (GO:0140833)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1).
Synonyms: RNA polymerase II C-terminal domain Y1 kinase activity
RNA polymerase II CTD heptapeptide repeat S2 kinase activity (GO:0140834)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2).
Synonyms: RNA polymerase II C-terminal domain S2 kinase activity
RNA polymerase II CTD heptapeptide repeat T4 kinase activity (GO:0140835)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4).
Synonyms: RNA polymerase II C-terminal domain T4 kinase activity
RNA polymerase II CTD heptapeptide repeat S5 kinase activity (GO:0140836)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5).
Synonyms: RNA polymerase II C-terminal domain S5 kinase activity
RNA polymerase II CTD heptapeptide repeat S7 kinase activity (GO:0140837)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7).
Synonyms: RNA polymerase II C-terminal domain S7 kinase activity
RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity (GO:0140838)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0).
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity (GO:0140839)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3).
Synonyms: RNA polymerase II C-terminal domain P3 isomerase activity
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity (GO:0140840)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6).
Synonyms: RNA polymerase II C-terminal domain P6 isomerase activity
RNA polymerase II C-terminal domain O-GlcNAc transferase activity (GO:0140841)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine.
RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity (GO:0140842)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5).
RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity (GO:0140843)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7).
NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity (GO:0140844)
Namespace: molecular_function
Definition: Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue).
Synonyms: NAD+-histone H2B-E2 glutamate ADP-ribosyltransferase activity; NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E2 specific)
Comment: Note that the residue position corresponds to the canonical human H2B histone (UniProtKB:P62807); the N-terminus of histone H2B is divergent across eukaryotes; make sure that the paper clearly references the human protein for the position of this modification to use this term. Corresponds to histone H2BE18  in Dictyostelium (PMID:28252050). Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
regulation of promoter clearance from RNA polymerase II promoter (GO:0140845)
Namespace: biological_process
Definition: A process that modulates the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II.
positive regulation of promoter clearance from RNA polymerase II promoter (GO:0140846)
Namespace: biological_process
Definition: A process that activates or increases the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II.
negative regulation of promoter clearance from RNA polymerase II promoter (GO:0140847)
Namespace: biological_process
Definition: A process that stops, prevents or reduces the transition from the initiation to the elongation phases of transcription by RNA polymerase II.
amino acid:monoatomic cation antiporter activity (GO:0140848)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc.
histone H2B C-terminal K residue ubiquitin ligase activity (GO:0140850)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals.
Synonyms: histone H2B conserved C-terminal lysine ubiquitin ligase activity; histone H2B-K120 ubiquitin ligase activity; histone H2BK120 ubiquitin ligase activity; histone ubiquitin ligase activity (H2B-K120 specific)
histone H3K14 ubiquitin ligase activity (GO:0140851)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue.
Synonyms: histone H3-K14 ubiquitin ligase activity; histone ubiquitin ligase activity (H3-K14 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone ubiquitin ligase activity (GO:0140852)
Namespace: molecular_function
Definition: Catalysis of the transfer of ubiquitin to a histone substrate.
cholesterol-protein transferase activity (GO:0140853)
Namespace: molecular_function
Definition: Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein].
Synonyms: cholesterol transferase activity
interleukin-19-mediated signaling pathway (GO:0140854)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-19 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL19-mediated signalling pathway
histone H3S57 kinase activity (GO:0140855)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3.
Synonyms: histone kinase activity (H3-S57 specific); histone serine kinase activity (H3-S57 specific); histone-serine kinase activity (H3-S57 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2AK13 ubiquitin ligase activity (GO:0140856)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue.
Synonyms: histone ubiquitin ligase activity (H2A-K13 specific)
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3T45 kinase activity (GO:0140857)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3.
Synonyms: histone kinase activity (H3-T45 specific); histone threonine kinase activity (H3-T45 specific); histone-threonine kinase activity (H3-T45 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2AK15 ubiquitin ligase activity (GO:0140858)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue.
Synonyms: histone ubiquitin ligase activity (H2A-K15 specific)
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
(3R)-2'-hydroxyisoflavanone reductase (NADP+) activity (GO:0140860)
Namespace: molecular_function
Definition: Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH.
Synonyms: vestitone reductase activity
DNA repair-dependent chromatin remodeling (GO:0140861)
Namespace: biological_process
Definition: A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions.
Synonyms: DNA damage-dependent chromatin remodelling
histone H2AK119 ubiquitin ligase activity (GO:0140862)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue.
Synonyms: histone H2A-K119 ubiquitin ligase activity; histone ubiquitin ligase activity (H2A-K119 specific)
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2AK127 ubiquitin ligase activity (GO:0140863)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-127 residue.
Synonyms: histone H2A-K127 ubiquitin ligase activity; histone ubiquitin ligase activity (H2A-K127 specific)
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is only present in vertebrates. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2AK129 ubiquitin ligase activity (GO:0140864)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue.
Synonyms: histone H2A-K129 ubiquitin ligase activity; histone ubiquitin ligase activity (H2A-K129 specific)
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is only present in vertebrates. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
interleukin-22-mediated signaling pathway (GO:0140865)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-22 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-22-mediated signaling pathway; interleukin-22-mediated signalling pathway
obsolete NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity (GO:0140867)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue).
Synonyms: NAD+-histone H2B-E18 glutamate ADP-ribosyltransferase activity; NAD+-histone-glutamate ADP-ribosyltransferase activity (H2B-E18 specific)
Comment: This term was obsoleted because it corresponds to the Dictyostelium position for NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity ; GO:0140844.