LiteFold/GO huggingface dataset:
negative regulation of sterol transport (GO:0032372)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of sterol transport; down-regulation of sterol transport; downregulation of sterol transport; inhibition of sterol transport
positive regulation of sterol transport (GO:0032373)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of sterol transport; stimulation of sterol transport; up regulation of sterol transport; up-regulation of sterol transport; upregulation of sterol transport
regulation of cholesterol transport (GO:0032374)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of cholesterol transport (GO:0032375)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of cholesterol transport; down-regulation of cholesterol transport; downregulation of cholesterol transport; inhibition of cholesterol transport
positive regulation of cholesterol transport (GO:0032376)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of cholesterol transport; stimulation of cholesterol transport; up regulation of cholesterol transport; up-regulation of cholesterol transport; upregulation of cholesterol transport
negative regulation of intracellular lipid transport (GO:0032378)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.
Synonyms: down regulation of intracellular lipid transport; down-regulation of intracellular lipid transport; downregulation of intracellular lipid transport; inhibition of intracellular lipid transport
positive regulation of intracellular lipid transport (GO:0032379)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.
Synonyms: activation of intracellular lipid transport; stimulation of intracellular lipid transport; up regulation of intracellular lipid transport; up-regulation of intracellular lipid transport; upregulation of intracellular lipid transport
regulation of intracellular sterol transport (GO:0032380)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells.
negative regulation of intracellular sterol transport (GO:0032381)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells.
Synonyms: down regulation of intracellular sterol transport; down-regulation of intracellular sterol transport; downregulation of intracellular sterol transport; inhibition of intracellular sterol transport
regulation of intracellular cholesterol transport (GO:0032383)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells.
positive regulation of intracellular cholesterol transport (GO:0032385)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells.
Synonyms: activation of intracellular cholesterol transport; stimulation of intracellular cholesterol transport; up regulation of intracellular cholesterol transport; up-regulation of intracellular cholesterol transport; upregulation of intracellular cholesterol transport
regulation of intracellular transport (GO:0032386)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
negative regulation of intracellular transport (GO:0032387)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
Synonyms: down regulation of intracellular transport; down-regulation of intracellular transport; downregulation of intracellular transport; inhibition of intracellular transport
positive regulation of intracellular transport (GO:0032388)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
Synonyms: activation of intracellular transport; stimulation of intracellular transport; up regulation of intracellular transport; up-regulation of intracellular transport; upregulation of intracellular transport
MutLalpha complex (GO:0032389)
Namespace: cellular_component
Definition: A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
Synonyms: MLH1/PMS2 complex; MMR complex; MutL-alpha complex
MutLbeta complex (GO:0032390)
Namespace: cellular_component
Definition: A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.
Synonyms: MLH1/PMS1 complex; MMR complex
DNA geometric change (GO:0032392)
Namespace: biological_process
Definition: The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.
Comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo.
MHC class I receptor activity (GO:0032393)
Namespace: molecular_function
Definition: Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.
Synonyms: alpha-beta T cell receptor activity; gamma-delta T cell receptor activity; T cell receptor activity
Comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves.
MHC class Ib receptor activity (GO:0032394)
Namespace: molecular_function
Definition: Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.
Synonyms: alpha-beta T cell receptor activity; gamma-delta T cell receptor activity; T cell receptor activity
Comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves.
MHC class II receptor activity (GO:0032395)
Namespace: molecular_function
Definition: Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: alpha-beta T cell receptor activity; gamma-delta T cell receptor activity; T cell receptor activity
Comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves.
inhibitory MHC class I receptor activity (GO:0032396)
Namespace: molecular_function
Definition: Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte.
activating MHC class I receptor activity (GO:0032397)
Namespace: molecular_function
Definition: Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte.
HECT domain binding (GO:0032399)
Namespace: molecular_function
Definition: Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein.
melanosome transport (GO:0032402)
Namespace: biological_process
Definition: The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
mismatch repair complex binding (GO:0032404)
Namespace: molecular_function
Definition: Binding to a mismatch repair complex.
MutLalpha complex binding (GO:0032405)
Namespace: molecular_function
Definition: Binding to a MutLalpha mismatch repair complex.
MutLbeta complex binding (GO:0032406)
Namespace: molecular_function
Definition: Binding to a MutLbeta mismatch repair complex.
MutSalpha complex binding (GO:0032407)
Namespace: molecular_function
Definition: Binding to a MutSalpha mismatch repair complex.
MutSbeta complex binding (GO:0032408)
Namespace: molecular_function
Definition: Binding to a MutSbeta mismatch repair complex.
obsolete regulation of transporter activity (GO:0032409)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activity of a transporter.
Comment: This term was obsoleted because it represents a molecular function. Consider molecular function regulator activity ; GO:0098772 or a child.
negative regulation of transporter activity (GO:0032410)
Namespace: biological_process
Definition: Any process that stops or reduces the activity of a transporter.
Synonyms: down regulation of transporter activity; down-regulation of transporter activity; downregulation of transporter activity; inhibition of transporter activity
positive regulation of transporter activity (GO:0032411)
Namespace: biological_process
Definition: Any process that activates or increases the activity of a transporter.
Synonyms: activation of transporter activity; stimulation of transporter activity; up regulation of transporter activity; up-regulation of transporter activity; upregulation of transporter activity
obsolete regulation of monoatomic ion transmembrane transporter activity (GO:0032412)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activity of an ion transporter.
Synonyms: regulation of ion transmembrane transporter activity; regulation of ion transporter activity
Comment: This term was obsoleted because it represents a molecular function. Consider molecular function regulator activity ; GO:0098772 or a child.
negative regulation of ion transmembrane transporter activity (GO:0032413)
Namespace: biological_process
Definition: Any process that stops or reduces the activity of an ion transporter.
Synonyms: down regulation of ion transporter activity; down-regulation of ion transporter activity; downregulation of ion transporter activity; inhibition of ion transporter activity; negative regulation of ion transporter activity
positive regulation of ion transmembrane transporter activity (GO:0032414)
Namespace: biological_process
Definition: Any process that activates or increases the activity of an ion transporter.
Synonyms: activation of ion transporter activity; positive regulation of ion transporter activity; stimulation of ion transporter activity; up regulation of ion transporter activity; up-regulation of ion transporter activity; upregulation of ion transporter activity
obsolete regulation of sodium:proton antiporter activity (GO:0032415)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Synonyms: regulation of sodium:hydrogen antiporter activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of sodium:proton antiporter activity (GO:0032416)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Synonyms: down regulation of sodium:hydrogen antiporter activity; down-regulation of sodium:hydrogen antiporter activity; downregulation of sodium:hydrogen antiporter activity; inhibition of sodium:hydrogen antiporter activity; negative regulation of sodium:hydrogen antiporter activity
Comment: This term was obsoleted because it represents a molecular function. Consider molecular function regulator activity ; GO:0098772 or a child.
lysosome localization (GO:0032418)
Namespace: biological_process
Definition: Any process in which a lysosome is transported to, and/or maintained in, a specific location.
Synonyms: lysosome localisation
obsolete extrinsic component of lysosome membrane (GO:0032419)
Namespace: cellular_component
Definition: OBSOLETE. The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
Synonyms: extrinsic to lysosomal membrane; extrinsic to lysosome membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
stereocilium (GO:0032420)
Namespace: cellular_component
Definition: An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
stereocilium bundle (GO:0032421)
Namespace: cellular_component
Definition: A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.
Synonyms: stereocilia bundle
purine-rich negative regulatory element binding (GO:0032422)
Namespace: molecular_function
Definition: Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.
Synonyms: PNR element binding
regulation of mismatch repair (GO:0032423)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mismatch repair.
positive regulation of mismatch repair (GO:0032425)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mismatch repair.
Synonyms: activation of mismatch repair; stimulation of mismatch repair; up regulation of mismatch repair; up-regulation of mismatch repair; upregulation of mismatch repair
stereocilium tip (GO:0032426)
Namespace: cellular_component
Definition: A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.
GBD domain binding (GO:0032427)
Namespace: molecular_function
Definition: Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.
Synonyms: Cdc42/Rac interactive binding motif binding; CRIB motif binding; P21-Rho-binding domain binding; PMD binding
beta-N-acetylgalactosaminidase activity (GO:0032428)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides.
obsolete regulation of phospholipase A2 activity (GO:0032429)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activity of the enzyme phospholipase A2.
Comment: This term was obsoleted because it represents a molecular function.
obsolete positive regulation of phospholipase A2 activity (GO:0032430)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the activity of the enzyme phospholipase A2.
Synonyms: activation of phospholipase A2 activity; stimulation of phospholipase A2 activity; up regulation of phospholipase A2 activity; up-regulation of phospholipase A2 activity; upregulation of phospholipase A2 activity
Comment: This term was obsoleted because it represents a molecular function. Consider molecular function regulator activity ; GO:0098772 or a child.
actin filament bundle (GO:0032432)
Namespace: cellular_component
Definition: An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
Synonyms: actin cable
filopodium tip (GO:0032433)
Namespace: cellular_component
Definition: The end of a filopodium distal to the body of the cell.
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Synonyms: down regulation of proteasomal ubiquitin-dependent protein catabolic process; down-regulation of proteasomal ubiquitin-dependent protein catabolic process; downregulation of proteasomal ubiquitin-dependent protein catabolic process; inhibition of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Synonyms: activation of proteasomal ubiquitin-dependent protein catabolic process; stimulation of proteasomal ubiquitin-dependent protein catabolic process; up regulation of proteasomal ubiquitin-dependent protein catabolic process; up-regulation of proteasomal ubiquitin-dependent protein catabolic process; upregulation of proteasomal ubiquitin-dependent protein catabolic process
cuticular plate (GO:0032437)
Namespace: cellular_component
Definition: A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.
2-alkenal reductase [NAD(P)H] activity (GO:0032440)
Namespace: molecular_function
Definition: Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+.
Synonyms: 2-alkenal reductase [NAD(P)+] activity; n-alkanal:NAD(P)+ 2-oxidoreductase activity; NAD(P)H-dependent alkenal/one oxidoreductase activity
pheophorbide a oxygenase activity (GO:0032441)
Namespace: molecular_function
Definition: Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O.
phenylcoumaran benzylic ether reductase activity (GO:0032442)
Namespace: molecular_function
Definition: Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+.
Synonyms: PCBER activity
regulation of ergosterol biosynthetic process (GO:0032443)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.
activin responsive factor complex (GO:0032444)
Namespace: cellular_component
Definition: A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.
Synonyms: ARF complex
Comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor).
protein modification by small protein conjugation (GO:0032446)
Namespace: biological_process
Definition: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.
CBM complex (GO:0032449)
Namespace: cellular_component
Definition: A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation.
Synonyms: CARMA1-BCL10-Malt1 complex
obsolete maltose alpha-glucosidase activity (GO:0032450)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose.
Synonyms: maltase activity
Comment: This term was obsoleted because it represents a specific substrate of alpha-1,4-glucosidase activity ; GO:0004558.
demethylase activity (GO:0032451)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from a substrate.
histone demethylase activity (GO:0032452)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from a histone.
histone H3K4 demethylase activity (GO:0032453)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein.
Synonyms: histone demethylase activity (H3-K4 specific); histone demethylase activity (H3K4-specific); histone H3-K4 demethylase activity; histone H3-methyl-lysine-4 demethylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K9 demethylase activity (GO:0032454)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein.
Synonyms: histone demethylase activity (H3-K9 specific); histone H3-K49 demethylase activity; histone H3-methyl-lysine-9 demethylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.