LiteFold/GO huggingface dataset:
epithelial to mesenchymal transition (GO:0001837)
Namespace: biological_process
Definition: A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
Synonyms: EMT; epithelial-mesenchymal transition; mesenchymal cell differentiation from epithelial cell
embryonic epithelial tube formation (GO:0001838)
Namespace: biological_process
Definition: The morphogenesis of an embryonic epithelium into a tube-shaped structure.
neural plate morphogenesis (GO:0001839)
Namespace: biological_process
Definition: The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
neural plate development (GO:0001840)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
neural tube formation (GO:0001841)
Namespace: biological_process
Definition: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
Synonyms: neural tube morphogenesis; neurulation
neural fold formation (GO:0001842)
Namespace: biological_process
Definition: The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.
Synonyms: neural groove formation
neural tube closure (GO:0001843)
Namespace: biological_process
Definition: The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
obsolete protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:0001844)
Namespace: biological_process
Definition: OBSOLETE. The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.
Synonyms: insertion of proteins into mitochondrial membranes during the induction of apoptosis; protein insertion into mitochondrial membrane during induction of apoptosis; protein insertion into mitochondrial membrane involved in induction of apoptosis; protein insertion into mitochondrion membrane during induction of apoptosis
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
phagolysosome assembly (GO:0001845)
Namespace: biological_process
Definition: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.
Synonyms: late phagosome biosynthesis; late phagosome formation; phagolysosome formation
opsonin receptor activity (GO:0001847)
Namespace: molecular_function
Definition: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
complement binding (GO:0001848)
Namespace: molecular_function
Definition: Binding to a component or product of the complement cascade.
Comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
complement component C3a binding (GO:0001850)
Namespace: molecular_function
Definition: Binding to a C3a product of the complement cascade.
complement component C3b binding (GO:0001851)
Namespace: molecular_function
Definition: Binding to a C3b product of the complement cascade.
complement component iC3b binding (GO:0001852)
Namespace: molecular_function
Definition: Binding to a iC3b product of the complement cascade.
complement component C3dg binding (GO:0001853)
Namespace: molecular_function
Definition: Binding to a C3dg product of the complement cascade.
complement component C3d binding (GO:0001854)
Namespace: molecular_function
Definition: Binding to a C3d product of the complement cascade.
complement component C4b binding (GO:0001855)
Namespace: molecular_function
Definition: Binding to a C4b product of the classical complement cascade.
complement component C5a binding (GO:0001856)
Namespace: molecular_function
Definition: Binding to a C5a product of the complement cascade.
complement component C1q receptor activity (GO:0001857)
Namespace: molecular_function
Definition: Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
complement component iC3b receptor activity (GO:0001858)
Namespace: molecular_function
Definition: Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
complement component C3dg receptor activity (GO:0001859)
Namespace: molecular_function
Definition: Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
complement component C3d receptor activity (GO:0001860)
Namespace: molecular_function
Definition: Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
complement component C4b receptor activity (GO:0001861)
Namespace: molecular_function
Definition: Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
collectin binding (GO:0001862)
Namespace: molecular_function
Definition: Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.
Comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D).
pentraxin binding (GO:0001864)
Namespace: molecular_function
Definition: Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.
Comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
NK T cell differentiation (GO:0001865)
Namespace: biological_process
Definition: The process in which a precursor cell type acquires the specialized features of a NK T cell.
Synonyms: natural killer T cell differentiation; natural T cell differentiation; NK T cell development; NK T lymphocyte differentiation; NK T-cell differentiation; NK T-lymphocyte differentiation; NKT cell differentiation; NT cell differentiation
Comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
NK T cell proliferation (GO:0001866)
Namespace: biological_process
Definition: The expansion of a NK T cell population by cell division.
Synonyms: natural killer T cell proliferation; natural T cell proliferation; NK T lymphocyte proliferation; NK T-cell proliferation; NK T-lymphocyte proliferation; NKT cell proliferation; NT cell proliferation
Comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
regulation of complement activation, lectin pathway (GO:0001868)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.
Synonyms: regulation of complement cascade, lectin pathway
negative regulation of complement activation, lectin pathway (GO:0001869)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.
Synonyms: down regulation of complement activation, lectin pathway; down-regulation of complement activation, lectin pathway; downregulation of complement activation, lectin pathway; inhibition of complement activation, lectin pathway; negative regulation of complement cascade, lectin pathway
positive regulation of complement activation, lectin pathway (GO:0001870)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway.
Synonyms: activation of complement activation, lectin pathway; positive regulation of complement cascade, lectin pathway; stimulation of complement activation, lectin pathway; up regulation of complement activation, lectin pathway; up-regulation of complement activation, lectin pathway; upregulation of complement activation, lectin pathway
obsolete pattern binding (GO:0001871)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a repeating or polymeric structure, such as a polysaccharide or peptidoglycan.
Synonyms: pattern recognition activity
Comment: This term was obsoleted because it was an unnecessary grouping term.
(1->3)-beta-D-glucan binding (GO:0001872)
Namespace: molecular_function
Definition: Binding to a (1->3)-beta-D-glucan.
Synonyms: 1,3-beta-D-glucan binding; callose binding; zymosan binding
(1->3)-beta-D-glucan immune receptor activity (GO:0001874)
Namespace: molecular_function
Definition: Combining with (1->3)-beta-D-glucans to initiate an innate immune response.
Synonyms: (1,3)-beta-D-glucan receptor activity; (1->3)-beta-D-glucan receptor activity; 1,3-beta-D-glucan receptor activity; beta-1,3-D-glucan receptor activity; zymosan receptor activity
lipopolysaccharide immune receptor activity (GO:0001875)
Namespace: molecular_function
Definition: Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
Synonyms: endotoxin receptor activity; lipopolysaccharide receptor activity; LPS receptor activity
lipoarabinomannan binding (GO:0001876)
Namespace: molecular_function
Definition: Binding to lipoarabinomannan.
Synonyms: LAM binding
lipoarabinomannan immune receptor activity (GO:0001877)
Namespace: molecular_function
Definition: Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response.
Synonyms: LAM receptor activity; lipoarabinomannan receptor activity
response to yeast (GO:0001878)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
Comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast.
detection of yeast (GO:0001879)
Namespace: biological_process
Definition: The series of events in which a stimulus from a yeast is received and converted into a molecular signal.
receptor recycling (GO:0001881)
Namespace: biological_process
Definition: The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
nucleoside binding (GO:0001882)
Namespace: molecular_function
Definition: Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
purine nucleoside binding (GO:0001883)
Namespace: molecular_function
Definition: Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.
endothelial cell development (GO:0001885)
Namespace: biological_process
Definition: The progression of an endothelial cell over time, from its formation to the mature structure.
endothelial cell morphogenesis (GO:0001886)
Namespace: biological_process
Definition: The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
selenium compound metabolic process (GO:0001887)
Namespace: biological_process
Definition: The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
Synonyms: selenium compound metabolism; selenium metabolic process; selenium metabolism
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (GO:0001888)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H+ + UDP.
Synonyms: alpha-1,4-N-acetylglucosaminyltransferase activity; alpha-N-acetylglucosaminyltransferase I activity; alpha1,4-N-acetylglucosaminyltransferase activity; glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity; UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity
liver development (GO:0001889)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
placenta development (GO:0001890)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
Synonyms: placental development; placentation
phagocytic cup (GO:0001891)
Namespace: cellular_component
Definition: An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
embryonic placenta development (GO:0001892)
Namespace: biological_process
Definition: The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
Synonyms: fetal placenta development
maternal placenta development (GO:0001893)
Namespace: biological_process
Definition: Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
Synonyms: decidua development
tissue homeostasis (GO:0001894)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
Synonyms: tissue maintenance
retina homeostasis (GO:0001895)
Namespace: biological_process
Definition: A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.
autolysis (GO:0001896)
Namespace: biological_process
Definition: A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation.
symbiont-mediated cytolysis of host cell (GO:0001897)
Namespace: biological_process
Definition: A process mediated by a symbiont that results in the death of a host cell by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: cytolysis by organism of host cells; cytolysis by symbiont of host cells; pathogenesis
obsolete regulation of cytolysis by symbiont of host cells (GO:0001898)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: regulation by symbiont of cytolysis of host cells
Comment: This term was obsoleted because it has been used inconsistently.
obsolete positive regulation of cytolysis by symbiont of host cells (GO:0001900)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: activation by symbiont of cytolysis of host cells; positive regulation by symbiont of cytolysis of host cells; stimulation by symbiont of cytolysis of host cells; up regulation by symbiont of cytolysis of host cells; up-regulation by symbiont of cytolysis of host cells; upregulation by symbiont of cytolysis of host cells
Comment: This term was obsoleted because it has been used inconsistently.
activation of membrane attack complex (GO:0001905)
Namespace: biological_process
Definition: The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms: activation of MAC; activation of TCC; activation of terminal complement complex; activation of the terminal complement cascade; MAC assembly; MAC formation; membrane attack complex assembly; membrane attack complex formation
cell killing (GO:0001906)
Namespace: biological_process
Definition: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
Synonyms: necrosis
symbiont-mediated killing of host cell (GO:0001907)
Namespace: biological_process
Definition: A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: killing by symbiont of host cells; pathogenesis
leukocyte mediated cytotoxicity (GO:0001909)
Namespace: biological_process
Definition: The directed killing of a target cell by a leukocyte.
Synonyms: immune cell mediated cell death; immune cell mediated cell killing; immune cell mediated cytotoxicity; leucocyte mediated cytotoxicity
Comment: Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
regulation of leukocyte mediated cytotoxicity (GO:0001910)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
Synonyms: regulation of immune cell mediated cell death; regulation of immune cell mediated cell killing; regulation of immune cell mediated cytotoxicity; regulation of leucocyte mediated cytotoxicity
negative regulation of leukocyte mediated cytotoxicity (GO:0001911)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
Synonyms: down regulation of leukocyte mediated cytotoxicity; down-regulation of leukocyte mediated cytotoxicity; downregulation of leukocyte mediated cytotoxicity; inhibition of leukocyte mediated cytotoxicity; negative regulation of immune cell mediated cytotoxicity; negative regulation of leucocyte mediated cytotoxicity
positive regulation of leukocyte mediated cytotoxicity (GO:0001912)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.
Synonyms: activation of leukocyte mediated cytotoxicity; positive regulation of immune cell mediated cytotoxicity; positive regulation of leucocyte mediated cytotoxicity; stimulation of leukocyte mediated cytotoxicity; up regulation of leukocyte mediated cytotoxicity; up-regulation of leukocyte mediated cytotoxicity; upregulation of leukocyte mediated cytotoxicity
T cell mediated cytotoxicity (GO:0001913)
Namespace: biological_process
Definition: The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Synonyms: T cell mediated apoptosis; T cell mediated cell death; T cell mediated cell killing; T cell mediated cytolysis; T lymphocyte mediated cytotoxicity; T-cell mediated apoptosis; T-cell mediated cell death; T-cell mediated cell killing; T-cell mediated cytotoxicity; T-lymphocyte mediated cytotoxicity
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
regulation of T cell mediated cytotoxicity (GO:0001914)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
Synonyms: regulation of T cell mediated apoptosis; regulation of T cell mediated cell death; regulation of T cell mediated cell killing; regulation of T cell mediated cytolysis; regulation of T lymphocyte mediated cytotoxicity; regulation of T-cell mediated apoptosis; regulation of T-cell mediated cell death; regulation of T-cell mediated cell killing; regulation of T-cell mediated cytolysis; regulation of T-cell mediated cytotoxicity; regulation of T-lymphocyte mediated cytotoxicity