LiteFold/GO huggingface dataset:
proton channel activity (GO:0015252)
Namespace: molecular_function
Definition: Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Synonyms: hydrogen ion channel activity
obsolete sugar/polyol channel activity (GO:0015253)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: sugar/polyol channel activity
Comment: This term was made obsolete because it represents two molecular functions.
glycerol channel activity (GO:0015254)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of glycerol through a transmembrane aqueous pore or channel.
obsolete propanediol channel activity (GO:0015255)
Namespace: molecular_function
Definition: OBSOLETE. Enables the energy-independent facilitated diffusion of propanediol through a transmembrane aqueous pore or channel.
Comment: The reason for obsoletion is that there is no evidence that this function exists.
obsolete monocarboxylate channel activity (GO:0015256)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: monocarboxylate channel activity
Comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
obsolete organic anion channel activity (GO:0015257)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: organic anion channel activity
Comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
obsolete gluconate channel activity (GO:0015258)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: gluconate channel activity
Comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
obsolete glutamate channel activity (GO:0015259)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: glutamate channel activity
Comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
obsolete isethionate channel activity (GO:0015260)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: isethionate channel activity
Comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
obsolete lactate channel activity (GO:0015261)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: lactate channel activity
Comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
obsolete taurine channel activity (GO:0015262)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: taurine channel activity
Comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
obsolete amine/amide/polyamine channel activity (GO:0015263)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: amine/amide/polyamine channel activity
Comment: This term was made obsolete because it represents three molecular functions.
methylammonium channel activity (GO:0015264)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of methylammonium through a transmembrane aqueous pore or channel. Methylammonium is CH3NH2.
urea channel activity (GO:0015265)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of urea through a transmembrane aqueous pore or channel.
channel activity (GO:0015267)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
Synonyms: alpha-type channel activity; channel-forming toxin activity; channel/pore class transporter activity; nonselective channel activity; pore activity; pore class transporter activity; substrate-specific channel activity
outward rectifier potassium channel activity (GO:0015271)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.
ATP-activated inward rectifier potassium channel activity (GO:0015272)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
organellar voltage-gated chloride channel activity (GO:0015274)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane.
Synonyms: organellar voltage gated chloride channel activity; organellar voltage-dependent chloride channel activity
stretch-activated, monoatomic cation-selective, calcium channel activity (GO:0015275)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching.
Synonyms: stretch-activated, cation-selective, calcium channel activity
ligand-gated monoatomic ion channel activity (GO:0015276)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
Synonyms: ionotropic receptor activity; ligand-gated ion channel activity
kainate selective glutamate receptor activity (GO:0015277)
Namespace: molecular_function
Definition: An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist.
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
intracellularly gated calcium channel activity (GO:0015278)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
Synonyms: calcium-release channel activity; intracellular ligand-gated calcium channel activity
store-operated calcium channel activity (GO:0015279)
Namespace: molecular_function
Definition: A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
ligand-gated sodium channel activity (GO:0015280)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
Synonyms: acid-sensing ion channel activity; epithelial sodium channel
obsolete NADPH oxidase-associated cytochrome b558 hydrogen channel activity (GO:0015282)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: NADPH oxidase-associated cytochrome b558 hydrogen channel activity; NADPH oxidase-associated cytochrome b558 proton channel
Comment: This term was made obsolete because it describes a gene product rather than a function.
obsolete apoptogenic cytochrome c release channel activity (GO:0015283)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: apoptogenic cytochrome c release channel activity; Bcl-2
Comment: This term was made obsolete because it represents a gene product.
fructose uniporter activity (GO:0015284)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in).
porin activity (GO:0015288)
Namespace: molecular_function
Definition: Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
Synonyms: outer membrane exporter porin; porin
obsolete pore-forming toxin activity (GO:0015289)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell.
Synonyms: pore-forming toxin activity
Comment: This term was made obsolete because it represents a class of gene products.
secondary active transmembrane transporter activity (GO:0015291)
Namespace: molecular_function
Definition: Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters.
Synonyms: active transporter; coupled carrier; electrochemical potential-driven transporter activity; energizer of outer membrane receptor-mediated transport activity; galactose/glucose (methylgalactoside) porter activity; heavy metal ion porter activity; ion-gradient-driven energizer activity; multidrug endosomal transmembrane transporter activity; nitrite/nitrate porter activity; porter activity; porters; secondary carrier-type facilitators
symporter activity (GO:0015293)
Namespace: molecular_function
Definition: Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
Synonyms: cotransporter activity; porter activity; symport
solute:monoatomic cation symporter activity (GO:0015294)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).
Synonyms: solute:cation symporter activity
solute:proton symporter activity (GO:0015295)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).
Synonyms: heavy metal ion:hydrogen symporter activity; high affinity metal ion uptake transporter activity; L-idonate/D-gluconate:hydrogen symporter activity; low affinity metal ion uptake transporter activity; proline/glycine/betaine:hydrogen/sodium symporter activity; solute:hydrogen symporter activity
monoatomic anion:monoatomic cation symporter activity (GO:0015296)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).
Synonyms: anion:cation symporter activity
antiporter activity (GO:0015297)
Namespace: molecular_function
Definition: Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
Synonyms: antiport; countertransporter activity; exchange transporter activity; exchanger; ion antiporter activity; porter; solute:solute antiporter activity; solute:solute exchange
obsolete solute:monoatomic cation antiporter activity (GO:0015298)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out).
Synonyms: solute:cation antiporter activity
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete solute:proton antiporter activity (GO:0015299)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
Synonyms: L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity; solute:hydrogen antiporter activity
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete anion:anion antiporter activity (GO:0015301)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
Synonyms: anion exchanger activity; bicarbonate:chloride antiporter
Comment: This term was obsoleted because it was too general for a grouping class.
obsolete galactose, glucose uniporter activity (GO:0015303)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in).
Synonyms: galactose, glucose uniporter activity
Comment: This term was made obsolete because it represents two molecular functions.
D-glucose uniporter activity (GO:0015304)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) = D-glucose(in).
Synonyms: galactose, glucose uniporter activity; glucose uniporter activity
obsolete lactose, galactose:proton symporter activity (GO:0015305)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in).
Synonyms: lactose, galactose:hydrogen symporter activity; lactose, galactose:proton symporter activity; lactose,galactose:proton symporter activity
Comment: This term was made obsolete because it represents two molecular functions.
sialate:monoatomic cation symporter activity (GO:0015306)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in).
Synonyms: cation/sialate symporter activity; cation:sialate symporter activity; sialate transporter activity; sialate/cation symporter activity; sialate:cation symporter activity
obsolete drug:proton antiporter activity (GO:0015307)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out).
Synonyms: carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity; drug:hydrogen antiporter activity
Comment: This term was obsoleted because it is not possible to state that every case of transmembrane transport for a specific chemical constitutes a drug transport.
obsolete amiloride:proton antiporter activity (GO:0015308)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out).
Synonyms: amiloride:hydrogen antiporter activity
Comment: The reason for obsoletion is that these terms are beyond the scope of GO.
cycloheximide:proton antiporter activity (GO:0015309)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out).
Synonyms: cycloheximide:hydrogen antiporter activity
benomyl:proton antiporter activity (GO:0015310)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out).
Synonyms: benomyl:hydrogen antiporter activity
monoamine:proton antiporter activity (GO:0015311)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out).
Synonyms: monoamine:hydrogen antiporter activity
fluconazole:proton antiporter activity (GO:0015313)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out).
Synonyms: fluconazole:hydrogen antiporter activity
organophosphate:phosphate antiporter activity (GO:0015315)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + phosphate(in) = organophosphate(in) +  phosphate(out).
Synonyms: organophosphate:inorganic phosphate antiporter activity
obsolete nitrite/nitrate porter activity (GO:0015316)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: nitrite/nitrate porter activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
phosphate:proton symporter activity (GO:0015317)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in).
Synonyms: phosphate ion carrier activity; phosphate:hydrogen symporter activity
obsolete sodium:inorganic phosphate symporter activity (GO:0015319)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).
Synonyms: sodium:phosphate symporter activity
Comment: This term was obsoleted because it represents the same activity as sodium:phosphate symporter activity ; GO:0005436.
obsolete secondary active oligopeptide transmembrane transporter activity (GO:0015322)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
Synonyms: oligopeptide porter activity
Comment: This term was obsoleted because it does not define a specific transport mechanism.
obsolete type V protein secretor activity (GO:0015323)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: type V protein secretor activity
Comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
obsolete peptide-acetyl-CoA secondary active transmembrane transporter activity (GO:0015324)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: peptide-acetyl-CoA transporter activity
Comment: This term was obsoleted because it does not define a specific transport mechanism.
acetyl-CoA:CoA antiporter activity (GO:0015325)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out).
cystine:glutamate antiporter activity (GO:0015327)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out).
obsolete cystine secondary active transmembrane transporter activity (GO:0015328)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: cystine porter activity; cystinosin; lysosomal cystine transporter
Comment: This term was obsoleted because it does not define a specific transport mechanism.
high-affinity glutamine transmembrane transporter activity (GO:0015330)
Namespace: molecular_function
Definition: Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity glutamine permease activity; high affinity glutamine transmembrane transporter activity
obsolete asparagine/glutamine permease activity (GO:0015331)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane.
Synonyms: asparagine/glutamine permease activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
obsolete leucine/valine/isoleucine permease activity (GO:0015332)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: leucine/valine/isoleucine permease activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
high-affinity oligopeptide transmembrane transporter activity (GO:0015334)
Namespace: molecular_function
Definition: Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
Synonyms: high affinity oligopeptide transporter activity; high-affinity oligopeptide transporter activity
obsolete heavy metal ion:hydrogen symporter activity (GO:0015335)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+.
Synonyms: heavy metal ion:hydrogen symporter activity; heavy metal ion:proton symporter activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.