LiteFold/GO huggingface dataset:
ATP-dependent DNA/DNA annealing activity (GO:0036310)
Namespace: molecular_function
Definition: An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule.
Synonyms: annealing helicase activity; ATP-dependent DNA annealing activity; DNA rewinding activity; nucleoside-triphosphatase activity involved in DNA annealing
chitin disaccharide deacetylase activity (GO:0036311)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine.
Synonyms: chitin oligosaccharide amidohydrolase activity; chitin oligosaccharide deacetylase activity; chitobiose amidohydrolase activity
Comment: In contrast to EC:3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide.
phosphatidylinositol 3-kinase catalytic subunit binding (GO:0036313)
Namespace: molecular_function
Definition: Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
Synonyms: p110 binding; PI3K catalytic subunit binding
response to sterol (GO:0036314)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus.
SREBP-SCAP complex retention in endoplasmic reticulum (GO:0036316)
Namespace: biological_process
Definition: Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER.
Comment: Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937.
tyrosyl-RNA phosphodiesterase activity (GO:0036317)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.
Synonyms: unlinkase activity; uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity; VPg unlinkase activity; Y-pUpN PDE activity
peptide pheromone receptor activity (GO:0036318)
Namespace: molecular_function
Definition: Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity.
mating-type M-factor pheromone receptor activity (GO:0036319)
Namespace: molecular_function
Definition: Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus.
Synonyms: M-factor mating pheromone receptor activity; M-factor receptor activity
mating-type P-factor pheromone receptor activity (GO:0036320)
Namespace: molecular_function
Definition: Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus.
Synonyms: P-factor mating pheromone receptor activity; P-factor receptor activity
ghrelin secretion (GO:0036321)
Namespace: biological_process
Definition: The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone.
Synonyms: pancreatic ghrelin secretion
vascular endothelial growth factor receptor-1 signaling pathway (GO:0036323)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: FLT1 signaling pathway; VEGFR-1 signaling pathway; VEGFR1 signaling pathway
vascular endothelial growth factor receptor-2 signaling pathway (GO:0036324)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: FLK-1 signaling pathway; KDR signaling pathway; VEGFR-2 signaling pathway; VEGFR2 signaling pathway
vascular endothelial growth factor receptor-3 signaling pathway (GO:0036325)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-3 (VEGFR-3) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: FLT4 signaling pathway; VEGFR-3 signaling pathway; VEGFR3 signaling pathway
avascular cornea development in camera-type eye (GO:0036331)
Namespace: biological_process
Definition: The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees.
Synonyms: avascular cornea development
placental growth factor receptor activity (GO:0036332)
Namespace: molecular_function
Definition: Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: placental growth factor-activated receptor activity; PlGF receptor activity; PlGF-activated receptor activity
hepatocyte homeostasis (GO:0036333)
Namespace: biological_process
Definition: Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.
epidermal stem cell homeostasis (GO:0036334)
Namespace: biological_process
Definition: Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.
intestinal stem cell homeostasis (GO:0036335)
Namespace: biological_process
Definition: Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.
Synonyms: intestinal crypt stem cell homeostasis
dendritic cell migration (GO:0036336)
Namespace: biological_process
Definition: The movement of a dendritic cell within or between different tissues and organs of the body.
Fas signaling pathway (GO:0036337)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.
Synonyms: Apo-1 signaling pathway; CD95 signaling pathway; FAS ligand-Fas signaling pathway; Fas receptor signaling pathway; Fas-FasL signaling pathway; FasL signaling pathway; FasR signaling pathway
viral membrane (GO:0036338)
Namespace: cellular_component
Definition: The lipid bilayer of a virion, a complete fully infectious extracellular virus particle.
lymphocyte adhesion to endothelial cell of high endothelial venule (GO:0036339)
Namespace: biological_process
Definition: The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream.
Synonyms: lymphocyte adhesion to HEV cell; lymphocyte adhesion to high endothelial venule
Comment: For the transition of leukocytes from rolling to adhered, consider instead annotating to 'leukocyte adhesive activation ; GO:0050902'.
chitin-based cuticle sclerotization by biomineralization (GO:0036340)
Namespace: biological_process
Definition: The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate.
Synonyms: chitin-based cuticle hardening by biomineralisation
chitin-based cuticle sclerotization by protein cross-linking (GO:0036341)
Namespace: biological_process
Definition: The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle.
Synonyms: chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning
post-anal tail morphogenesis (GO:0036342)
Namespace: biological_process
Definition: The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
psychomotor behavior (GO:0036343)
Namespace: biological_process
Definition: The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument.
platelet morphogenesis (GO:0036344)
Namespace: biological_process
Definition: Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
platelet maturation (GO:0036345)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
cellular response to L-cysteine (GO:0036346)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration.
hydantoin racemase activity (GO:0036348)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin.
galactose-specific flocculation (GO:0036349)
Namespace: biological_process
Definition: The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other.
Synonyms: cell-cell adhesion involved in galactose-specific flocculation
mannose-specific flocculation (GO:0036350)
Namespace: biological_process
Definition: The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other.
Synonyms: cell-cell adhesion involved in mannose-specific flocculation
obsolete histone H2A-K13 ubiquitination (GO:0036351)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin.
Synonyms: histone H2A ubiquitination (H2A-K13)
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H2A-K15 ubiquitination (GO:0036352)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin.
Synonyms: histone H2A ubiquitination (H2A-K15)
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H2A-K119 monoubiquitination (GO:0036353)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
Synonyms: histone H2A monoubiquitination (H2A-K119)
Comment: This term was obsoleted because it represents a molecular function.
2-iminoacetate synthase activity (GO:0036355)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+.
cyclic 2,3-diphosphoglycerate synthetase activity (GO:0036356)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate.
Synonyms: cDPGS activity; CPGS activity
Comment: This reaction is the intramolecular cyclization of 2,3-diphosphoglycerate to cyclic 2,3-diphosphoglycerate and is the second step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG).
obsolete 2-phosphoglycerate kinase activity (GO:0036357)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP.
Synonyms: 2PGK activity
Comment: This term was obsoleted because there is no evidence that this specific activity exists.
lipoteichoic acid D-alanylation (GO:0036358)
Namespace: biological_process
Definition: The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA).
Synonyms: D-alanyl lipoteichoic acid formation; D-alanyl LTA formation; LTA D-alanylation
renal potassium excretion (GO:0036359)
Namespace: biological_process
Definition: The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.
Synonyms: renal K(+) excretion; renal K+ elimination; renal potassium ion excretion
sorocarp stalk morphogenesis (GO:0036360)
Namespace: biological_process
Definition: The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.
Synonyms: fruiting body stalk morphogenesis
obsolete transforming growth factor beta activation (GO:0036363)
Namespace: biological_process
Definition: OBSOLETE. The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.
Synonyms: L-TGF-beta activation; latent TGF-beta activation; TGF-B activation; TGF-beta activation; TGFB activation; TGFbeta activation
Comment: The reason for obsoletion is that this represents a molecular function.
obsolete transforming growth factor beta1 activation (GO:0036364)
Namespace: biological_process
Definition: OBSOLETE. The release of transforming growth factor beta1 (TGF-beta1) from its latent state.
Synonyms: L-TGF-beta 1 activation; latent-TGF-beta1 activation; TGF-beta 1 activation; TGFB1 activation; TGFbeta 1 activation; transforming growth factor-beta1 activation
Comment: The reason for obsoletion is that this represents a molecular function.
obsolete transforming growth factor beta3 activation (GO:0036366)
Namespace: biological_process
Definition: OBSOLETE. The release of transforming growth factor beta 3 (TGF-beta3) from its latent state.
Synonyms: TGF-beta 3 activation; TGFB3 activation; TGFbeta 3 activation
Comment: The reason for obsoletion is that these represent molecular functions.
light adaption (GO:0036367)
Namespace: biological_process
Definition: The ability of a photoreceptor to adjust to varying levels of light.
Comment: Light adaptation is usually a combination of cell desensitization and response acceleration.
cone photoresponse recovery (GO:0036368)
Namespace: biological_process
Definition: The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.
Synonyms: cone phototransduction termination; cone response recovery
obsolete transcription factor catabolic process (GO:0036369)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Synonyms: proteasome-mediated transcription factor catabolism; sequence-specific DNA binding transcription factor catabolic process; transcription factor breakdown; transcription factor catabolism; transcription factor degradation
Comment: The reason for obsoletion is that this does not represent a specific pathway but a class of substrates.
D-alanyl carrier activity (GO:0036370)
Namespace: molecular_function
Definition: Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG).
Synonyms: D-alanyl carrier protein
protein localization to T-tubule (GO:0036371)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.
Synonyms: protein localisation to T-tubule; protein localization to T tubule; protein localization to transverse tubule
opsin transport (GO:0036372)
Namespace: biological_process
Definition: The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
Synonyms: ciliary transport of opsin
L-fucose mutarotase activity (GO:0036373)
Namespace: molecular_function
Definition: Catalysis of the reaction: alpha-L-fucose = beta-L-fucose.
Synonyms: alpha-L-fucose 1-epimerase activity; fucose 1-epimerase activity; type-2 mutarotase activity
glutathione gamma-glutamate hydrolase (GO:0036374)
Namespace: molecular_function
Definition: Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate.
Synonyms: gamma-glutamyltranspeptidase activity; glutathionase activity; glutathione hydrolase activity
Kibra-Ex-Mer complex (GO:0036375)
Namespace: cellular_component
Definition: An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2.
Synonyms: Kbr, Ex and Mer complex; KEM complex
sodium ion export across plasma membrane (GO:0036376)
Namespace: biological_process
Definition: The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
Synonyms: sodium export; sodium ion export; sodium ion export from cell
arbuscular mycorrhizal association (GO:0036377)
Namespace: biological_process
Definition: A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil.
Synonyms: arbuscular mycorrhizae formation; arbuscular mycorrhizal symbiosis; arbuscular mycorrhizas formation
calcitriol biosynthetic process from calciol (GO:0036378)
Namespace: biological_process
Definition: Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms: 1alpha,25(OH)2D3 biosynthesis; 1alpha,25-dihydroxycholecalciferol biosynthesis; 1alpha,25-dihydroxyvitamin D3 biosynthesis; calcitriol biosynthesis from calciol; vitamin D3 activation
myofilament (GO:0036379)
Namespace: cellular_component
Definition: Any of the smallest contractile units of a myofibril (striated muscle fiber).
Synonyms: striated muscle filament
UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity (GO:0036380)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol.
Synonyms: GlcNAc-P-P-Und synthase activity; UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity; UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity; UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity; UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity
pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity (GO:0036381)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH4+, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4+ = pyridoxal 5'-phosphate + 4 H2O + phosphate.
Synonyms: PdxST activity; pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity
flavin reductase (NADH) activity (GO:0036382)
Namespace: molecular_function
Definition: Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH.
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity (GO:0036383)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O.
bacterial nucleoid DNA packaging (GO:0036386)
Namespace: biological_process
Definition: A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling.
Synonyms: chromosomal compaction; nucleoid compaction; prokaryotic DNA condensation