LiteFold/GO huggingface dataset:
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Namespace: molecular_function
Definition: Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
Synonyms: ATP:cyclin phosphotransferase activity; cdc2 kinase activity; CDK; CDK activity; CDK, catalytic subunit activity; cdk-activating kinase activity; Cdk-activating protein kinase activity; cyclin D-cdk6 kinase activity; cyclin D-dependent kinase activity; cyclin E kinase activity; cyclin-A associated kinase activity; cyclin-dependent kinase 6 activity; cyclin-dependent kinase activity; cyclin-dependent kinase-2 activity; cyclin-dependent kinase-4 activity; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase, intrinsic catalyst activity; D-type cyclin kinase activity; neuronal cdc2-like kinase activity
Comment: This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
eukaryotic translation initiation factor 2alpha kinase activity (GO:0004694)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.
diacylglycerol-dependent serine/threonine kinase activity (GO:0004697)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
Synonyms: ATP:protein phosphotransferase (diacylglycerol-dependent) activity; cPKC; cPKCalpha; cPKCbeta; cPKCgamma; diacylglycerol-activated phospholipid-dependent PKC activity; diacylglycerol-activated phospholipid-dependent protein kinase C activity; nPKC; nPKCdelta; nPKCepsilon; nPKCeta; nPKCtheta; PKC; PKC activity; Pkc1p; PKCalpha; PKCbeta; PKCdelta; PKCepsilon; PKCgamma; protein kinase Cepsilon activity; STK24
calcium,diacylglycerol-dependent serine/threonine kinase activity (GO:0004698)
Namespace: molecular_function
Definition: Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction is activated in the presence of diacylglycerol and calcium.
Synonyms: calcium-dependent PKC activity; conventional protein kinase C activity
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (GO:0004699)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction is activated by diacylglycerol but not by calcium.
Synonyms: atypical protein kinase C activity; calcium-independent PKC activity; novel protein kinase C activity
obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity (GO:0004702)
Namespace: molecular_function
Definition: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
Synonyms: receptor signaling protein serine/threonine kinase activity; receptor signalling protein serine/threonine kinase activity
Comment: This term was obsoleted because it was not clearly defined.
G protein-coupled receptor kinase activity (GO:0004703)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.
Synonyms: ATP:G-protein-coupled receptor phosphotransferase activity; G protein coupled receptor phosphorylating protein kinase activity; G-protein coupled receptor kinase activity; G-protein-coupled receptor phosphorylating protein kinase activity; GPCR kinase activity; GPCR phosphorylating protein kinase activity; GPCRK; GRK4; GRK5; GRK6; STK16
obsolete NF-kappaB-inducing kinase activity (GO:0004704)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK).
Synonyms: NIK
Comment: This terms was obsoleted because it represents a specific gene product and it was instantiated as an enzyme regulator, but it is actually a protein kinase)This
JUN kinase activity (GO:0004705)
Namespace: molecular_function
Definition: Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.
Synonyms: c-Jun N-terminal kinase activity; JNK; JNK3alpha1; SAPK1
JUN kinase kinase kinase activity (GO:0004706)
Namespace: molecular_function
Definition: Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
Synonyms: JNK kinase kinase activity; JNKKK
MAP kinase activity (GO:0004707)
Namespace: molecular_function
Definition: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
Synonyms: ATP:protein phosphotransferase (MAPKK-activated) activity; ERK; ERK1; ERK2; extracellular signal-regulated kinase activity; MAP kinase 1 activity; MAP kinase 2 activity; MAPK; MBP kinase I activity; MBP kinase II activity; mitogen activated kinase activity; mitogen-activated protein kinase activity; myelin basic protein kinase activity; SAP kinase activity; SAPK; stress-activated kinase activity; stress-activated protein kinase activity
MAP kinase kinase activity (GO:0004708)
Namespace: molecular_function
Definition: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a T-X-Y motif in the activation loop of a MAP kinase (MAPK) substrate.
Synonyms: ATP:protein phosphotransferase (MAPKKK-activated) activity; ERK activator kinase activity; MAP kinase kinase 4 activity; MAP kinase kinase 7 activity; MAP kinase or ERK kinase activity; MAP2K; MAPK activator activity; MAPKK; MAPKK activity; MAPKK1; MEK activity; MEK1; MEK2; mitogen-activated protein kinase kinase activity; MKK; MKK2; MKK4; MKK6; MKK7; STK27
MAP kinase kinase kinase activity (GO:0004709)
Namespace: molecular_function
Definition: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
Synonyms: ATP:protein phosphotransferase (MAPKKKK-activated) activity; cMos; cRaf; MAP3K; MAPK/ERK kinase kinase activity; MAPKKK activity; MEK kinase activity; MEKK; MEKK activity; MEKK1; MEKK2; MEKK3; Mil/Raf; mitogen-activated protein kinase kinase kinase activity; MLK-like mitogen-activated protein triple kinase activity; MLTK; MLTKa; MLTKb; REKS; STK28
ribosomal protein S6 kinase activity (GO:0004711)
Namespace: molecular_function
Definition: Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
protein serine/threonine/tyrosine kinase activity (GO:0004712)
Namespace: molecular_function
Definition: Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Synonyms: dual-specificity kinase activity; dual-specificity protein kinase; protein threonine/tyrosine kinase activity
protein tyrosine kinase activity (GO:0004713)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Synonyms: protein-tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Namespace: molecular_function
Definition: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
Synonyms: receptor protein tyrosine kinase activity; receptor protein-tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity (GO:0004715)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
Synonyms: ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity; ATP:protein-tyrosine O-phosphotransferase activity; Bruton's tyrosine kinase activity; cytoplasmic protein tyrosine kinase activity; focal adhesion kinase activity; janus kinase 1 activity; janus kinase 2 activity; janus kinase 3 activity; non-specific protein-tyrosine kinase activity; p60c-src protein tyrosine kinase activity
obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity (GO:0004716)
Namespace: molecular_function
Definition: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
Synonyms: receptor signaling protein tyrosine kinase activity; receptor signalling protein tyrosine kinase activity
Comment: This term was obsoleted because it was not clearly defined.
obsolete focal adhesion kinase activity (GO:0004717)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: FAK; focal adhesion kinase activity
Comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function.
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity (GO:0004719)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.
Synonyms: D-aspartyl/L-isoaspartyl methyltransferase activity; L-aspartyl/L-isoaspartyl protein methyltransferase activity; L-isoaspartyl protein carboxyl methyltransferase activity; L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity; protein (D-aspartate) methyltransferase activity; protein beta-aspartate O-methyltransferase activity; protein D-aspartate methyltransferase activity; protein L-isoaspartate methyltransferase activity; protein L-isoaspartyl methyltransferase activity; protein O-methyltransferase (L-isoaspartate); protein-beta-aspartate O-methyltransferase activity; protein-L-isoaspartate O-methyltransferase activity; protein-L-isoaspartate(D-aspartate) O-methyltransferase activity; S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity
protein-lysine 6-oxidase activity (GO:0004720)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4+.
Synonyms: lysyl oxidase activity; protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
phosphoprotein phosphatase activity (GO:0004721)
Namespace: molecular_function
Definition: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
Synonyms: phosphoprotein phosphohydrolase activity; protein phosphatase activity; protein phosphatase-1 activity; protein phosphatase-2A activity; protein phosphatase-2B activity; protein phosphatase-2C activity
protein serine/threonine phosphatase activity (GO:0004722)
Namespace: molecular_function
Definition: Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
Synonyms: magnesium-dependent protein serine/threonine phosphatase activity; phosphatase I; phosphatase II; phosphatase III; protein phosphatase type 1 activity; protein phosphatase type 2A activity; protein phosphatase type 2B activity; protein phosphatase type 2C activity; protein phosphatase-1; protein phosphatase-2A; protein phosphatase-2B; protein phosphatase-2C; protein serine phosphatase activity; protein threonine phosphatase activity; serine/threonine specific protein phosphatase activity
calcium-dependent protein serine/threonine phosphatase activity (GO:0004723)
Namespace: molecular_function
Definition: Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
Synonyms: calcineurin; calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity
non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)
Namespace: molecular_function
Definition: Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
obsolete prenylated protein tyrosine phosphatase activity (GO:0004727)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate.
Comment: This term was obsoleted because it represents a specific substrate of protein tyrosine phosphatase activity ; GO:0004725.
obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity (GO:0004728)
Namespace: molecular_function
Definition: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Synonyms: receptor signaling protein tyrosine phosphatase activity; receptor signalling protein tyrosine phosphatase activity
Comment: This term was obsoleted because it was not clearly defined.
oxygen-dependent protoporphyrinogen oxidase activity (GO:0004729)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX.
Synonyms: protoporphyrinogen-IX:oxygen oxidoreductase activity
purine-nucleoside phosphorylase activity (GO:0004731)
Namespace: molecular_function
Definition: Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
Synonyms: inosine phosphorylase activity; inosine-guanosine phosphorylase activity; PNPase activity; PUNPI; PUNPII; purine deoxynucleoside phosphorylase activity; purine deoxyribonucleoside phosphorylase activity; purine nucleoside phosphorylase activity; purine ribonucleoside phosphorylase activity; purine-nucleoside:phosphate ribosyltransferase activity
pyridoxal oxidase activity (GO:0004732)
Namespace: molecular_function
Definition: Catalysis of the reaction:  pyridoxal + H2O + O2 = 4-pyridoxate + H+ + H2O2.
Synonyms: pyridoxal:oxygen 4-oxidoreductase activity
pyrimidodiazepine synthase activity (GO:0004734)
Namespace: molecular_function
Definition: Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione.
Synonyms: PDA synthase activity; pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
pyrroline-5-carboxylate reductase activity (GO:0004735)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
Synonyms: 1-pyrroline-5-carboxylate reductase activity; L-proline oxidase activity; L-proline-NAD(P)+ 5-oxidoreductase activity; L-proline:NAD(P)+ 5-oxidoreductase activity; NADPH-L-delta1-pyrroline carboxylic acid reductase activity; P5CR activity
pyruvate carboxylase activity (GO:0004736)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate.
Synonyms: pyruvate:carbon-dioxide ligase (ADP-forming); pyruvic carboxylase activity
pyruvate decarboxylase activity (GO:0004737)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.
Synonyms: 2-oxo-acid carboxy-lyase (aldehyde-forming); 2-oxo-acid carboxy-lyase activity; alpha-carboxylase activity; alpha-ketoacid carboxylase activity; pyruvic decarboxylase activity
obsolete pyruvate dehydrogenase activity (GO:0004738)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the oxidative decarboxylation of pyruvate.
Comment: This term was obsoleted because it is an unnecessary grouping term.
pyruvate dehydrogenase (acetyl-transferring) activity (GO:0004739)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.
Synonyms: MtPDC (mitochondrial pyruvate dehydogenase complex) activity; PDH; pyruvate dehydrogenase (lipoamide) activity; pyruvate dehydrogenase complex activity; pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating); pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity (GO:0004741)
Namespace: molecular_function
Definition: Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.
Synonyms: [pyruvate dehydrogenase (lipoamide)] phosphatase activity; [pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity; pyruvate dehydrogenase (lipoamide) phosphatase activity
dihydrolipoyllysine-residue acetyltransferase activity (GO:0004742)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA.
Synonyms: acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity; acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity; acetyl-CoA:dihydrolipoamide S-acetyltransferase activity; dihydrolipoamide S-acetyltransferase activity; dihydrolipoamide S-acyltransferase activity; dihydrolipoate acetyltransferase activity; dihydrolipoic transacetylase activity; dihydrolipoyl acetyltransferase activity; enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity; lipoate acetyltransferase activity; lipoate transacetylase activity; lipoic acetyltransferase activity; lipoic acid acetyltransferase activity; lipoic transacetylase activity; lipoylacetyltransferase activity; thioltransacetylase A activity; transacetylase X activity
Comment: The only observed direction catalyzed by this activity is that where the acetyl group is passed to coenzyme A - that is, the right-to-left direction of that shown in the definition.
pyruvate kinase activity (GO:0004743)
Namespace: molecular_function
Definition: Catalysis of the reaction: ADP + H+ + phosphoenolpyruvate = ATP + pyruvate.
Synonyms: ATP:pyruvate 2-O-phosphotransferase activity; phosphoenol transphosphorylase activity; phosphoenolpyruvate kinase activity
obsolete retinal isomerase activity (GO:0004744)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: all-trans-retinal = 11-cis-retinal.
Synonyms: all-trans-retinal 11-cis-trans-isomerase activity; retinene isomerase activity; retinoid isomerase activity
Comment: The Enzyme Commission has deleted the EC correspondingj to this term because it is now known to be catalysed by a pathway involving multiple enzymes.
all-trans-retinol dehydrogenase (NAD+) activity (GO:0004745)
Namespace: molecular_function
Definition: Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
Synonyms: all-trans retinol dehydrogenase activity; retinal reductase activity; retinene reductase activity; retinol (vitamin A1) dehydrogenase activity; retinol dehydrogenase activity
ribokinase activity (GO:0004747)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.
Synonyms: ATP:D-ribose 5-phosphotransferase activity; D-ribokinase activity; deoxyribokinase activity; ribokinase (phosphorylating)
ribose phosphate diphosphokinase activity (GO:0004749)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+.
Synonyms: 5-phosphoribose pyrophosphorylase activity; 5-phosphoribosyl-1-pyrophosphate synthetase activity; 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity; ATP:D-ribose-5-phosphate diphosphotransferase activity; phosphoribosyl diphosphate synthetase activity; phosphoribosyl pyrophosphate synthetase activity; phosphoribosyl-diphosphate synthetase activity; phosphoribosylpyrophosphate synthase activity; phosphoribosylpyrophosphate synthetase activity; PP-ribose P synthetase activity; PPRibP synthetase activity; PRPP synthetase activity; pyrophosphoribosylphosphate synthetase activity; ribophosphate pyrophosphokinase activity; ribose-5-phosphate pyrophosphokinase activity; ribose-phosphate diphosphokinase activity; ribose-phosphate pyrophosphokinase activity
D-ribulose-phosphate 3-epimerase activity (GO:0004750)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate.
Synonyms: D-ribulose 5-phosphate epimerase activity; D-ribulose phosphate-3-epimerase activity; D-ribulose-5-P 3-epimerase activity; D-ribulose-5-phosphate 3-epimerase activity; D-ribulose-5-phosphate epimerase activity; D-xylulose-5-phosphate 3-epimerase activity; erythrose-4-phosphate epimerase activity; erythrose-4-phosphate isomerase activity; pentose phosphate epimerase (PPE); pentose-5-phosphate 3-epimerase activity; phosphoketopentose 3-epimerase activity; phosphoketopentose epimerase activity; phosphoribulose epimerase activity; ribulose 5-phosphate 3-epimerase activity; ribulose-phosphate 3-epimerase activity; xylulose phosphate 3-epimerase activity
ribose-5-phosphate isomerase activity (GO:0004751)
Namespace: molecular_function
Definition: Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate.
Synonyms: 5-phosphoribose isomerase activity; D-ribose 5-phosphate isomerase activity; D-ribose-5-phosphate aldose-ketose-isomerase activity; D-ribose-5-phosphate ketol-isomerase activity; pentose phosphate isomerase (PPI); phosphopentoseisomerase activity; phosphopentosisomerase activity; phosphoriboisomerase activity; ribose 5-phosphate epimerase activity; ribose phosphate isomerase activity
saccharopine dehydrogenase activity (GO:0004753)
Namespace: molecular_function
Definition: Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.
Synonyms: lysine-2-oxoglutarate reductase activity; lysine-ketoglutarate reductase activity
saccharopine dehydrogenase (NAD+, L-lysine-forming) activity (GO:0004754)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH.
Synonyms: 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming); dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming); epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming); N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming); N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)