LiteFold/GO huggingface dataset:
positive regulation of lipoprotein transport (GO:0140077)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of lipoprotein transport.
class I DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140078)
Namespace: molecular_function
Definition: Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
Synonyms: AP endonuclease class I activity; AP lyase activity; AP site-DNA 5'-phosphomonoester-lyase activity; class I AP endonuclease activity; class I DNA-(apurinic or apyrimidinic site) lyase activity; DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity; DNA-(apurinic or apyrimidinic site) lyase activity
obsolete class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140080)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH.
Synonyms: endonuclease III; endonuclease IV
Comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.\nThe reason for obsoletion is that there is no longer credible evidence that this function exists.
glycosylated region protein binding (GO:0140081)
Namespace: molecular_function
Definition: Binding to a glycosylated region of a protein.
SUMO-ubiquitin ligase activity (GO:0140082)
Namespace: molecular_function
Definition: Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ATP-dependent protein-DNA unloader activity (GO:0140083)
Namespace: molecular_function
Definition: Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction.
Synonyms: ATP-dependent protein-DNA unloading activity; protein-DNA unloading ATPase activity
sexual macrocyst formation (GO:0140084)
Namespace: biological_process
Definition: The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum.
Synonyms: macrocyst formation; sexual fusion
L-amino-acid N-acetyltransferase activity (GO:0140085)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + a L-amino acid = CoA + an N-acetyl-L-amino-acid. In some cases other acetyl containing molecules can be used as donor.
acetaldehyde dehydrogenase (NAD+) activity (GO:0140087)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetaldehyde + NAD+ + H2O = acetate + NADH + 2 H+.
acetaldehyde dehydrogenase (NADP+) activity (GO:0140088)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetaldehyde + NADP+ + H2O = acetate + NADPH + 2 H+.
membrane curvature sensor activity (GO:0140090)
Namespace: molecular_function
Definition: Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.
mBAF complex (GO:0140091)
Namespace: cellular_component
Definition: A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof.
Synonyms: muscle-specific BAF complex; muscle-specific SWI/SNF complex; muscle-type BAF complex; muscle-type SWI/SNF complex
bBAF complex (GO:0140092)
Namespace: cellular_component
Definition: A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180.
Synonyms: brain-specific BAF complex; brain-specific SWI/SNF complex
esBAF complex (GO:0140093)
Namespace: cellular_component
Definition: An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C.
Synonyms: embryonic stem cell-specific BAF complex; embryonic stem cell-specific SWI/SNF complex
cytoplasmic lattice (GO:0140095)
Namespace: cellular_component
Definition: Fibrous structures of the mammalian ooplasm that store ribosomes and maternal proteins in insoluble form to prevent their degradation, activation and nuclear transfer.
catalytic activity, acting on a protein (GO:0140096)
Namespace: molecular_function
Definition: Catalytic activity that acts to modify a protein.
catalytic activity, acting on RNA (GO:0140098)
Namespace: molecular_function
Definition: Catalytic activity that acts to modify RNA.
venom-mediated suppression of fibrinolysis (GO:0140099)
Namespace: biological_process
Definition: A process in which an organism inhibits or disrupts fibrinolysis in another organism via the action of a venom. Fibrinolysis is the solubilization of fibrin in the bloodstream. Anti-fibrinolytic proteins reduce bleeding at the bite or sting site of the prey.
Synonyms: envenomation suppressing fibrinolysis in another organism
catalytic activity, acting on a tRNA (GO:0140101)
Namespace: molecular_function
Definition: Catalytic activity that acts to modify a tRNA.
Comment: Note that this term excludes activities for which a charged tRNA acts as an amino acid donor.
catalytic activity, acting on a rRNA (GO:0140102)
Namespace: molecular_function
Definition: Catalytic activity that acts to modify a ribosomal RNA.
catalytic activity, acting on a glycoprotein (GO:0140103)
Namespace: molecular_function
Definition: Catalysis of a biochemical reaction in which one of the substrates is a glycoprotein.
molecular carrier activity (GO:0140104)
Namespace: molecular_function
Definition: Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.
Comment: Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization.
interleukin-10-mediated signaling pathway (GO:0140105)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-10-mediated signaling pathway; interleukin-10-mediated signalling pathway
hematophagy (GO:0140106)
Namespace: biological_process
Definition: A feeding behavior that involves the ingestion of blood. Hematophagous animals have mouth parts and chemical agents for penetrating vascular structures in the skin of hosts. To overcome natural hemostasis, vasoconstriction, inflammation, and pain sensation in the host, hematophagous animals pre-inject chemical substances with anesthetic and/or anticoagulant properties.
Synonyms: feeding on blood of other organism; injection of substance into other organism during feeding on blood of other organism; taking of blood meal
high-affinity potassium ion transmembrane transporter activity (GO:0140107)
Namespace: molecular_function
Definition: Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high-affinity D-glucose transmembrane transporter activity (GO:0140108)
Namespace: molecular_function
Definition: Enables the transfer of D-glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high-affinity glucose transmembrane transporter activity
histone H3K4me1 reader activity (GO:0140109)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 monomethylated at lysine 4.
Synonyms: H3-K4me1 modified histone binding; H3K4me1 modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
transcription regulator activity (GO:0140110)
Namespace: molecular_function
Definition: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
[choline trimethylamine-lyase]-activating enzyme activity (GO:0140111)
Namespace: molecular_function
Definition: Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM).
extracellular vesicle biogenesis (GO:0140112)
Namespace: biological_process
Definition: The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.
Synonyms: extracellular vesicle assembly
extracellular microvesicle biogenesis (GO:0140113)
Namespace: biological_process
Definition: The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding.
Synonyms: extracellular microvesicle assembly
cellular detoxification of fluoride (GO:0140114)
Namespace: biological_process
Definition: Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
export across plasma membrane (GO:0140115)
Namespace: biological_process
Definition: The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
Synonyms: efflux
fluoride export across plasma membrane (GO:0140116)
Namespace: biological_process
Definition: The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region.
histone H4K20me1 reader activity (GO:0140117)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H4 monomethylated at lysine 20.
Synonyms: H4K20me1 modified histone binding
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H3K23ac reader activity (GO:0140118)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 acetylated at lysine 23.
Synonyms: histone H3K23ac modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K27ac reader activity (GO:0140119)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 acetylated at lysine 27.
Synonyms: histone H3K27ac modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2AK15ub reader activity (GO:0140120)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H2A ubiquitinated at lysine 15.
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
Lewy body formation (GO:0140121)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a Lewy body.
regulation of Lewy body formation (GO:0140122)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of Lewy body formation.
negative regulation of Lewy body formation (GO:0140123)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation.
positive regulation of Lewy body formation (GO:0140124)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of Lewy body formation.
thiamine import across plasma membrane (GO:0140125)
Namespace: biological_process
Definition: The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol.
histone H2AK15ac reader activity (GO:0140126)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H2A acetylated at lysine 15.
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3R8me2 reader activity (GO:0140127)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 dimethylate at arginine 8. The methylation can be symmetrical or asymmetrical.
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H1 reader activity (GO:0140128)
Namespace: molecular_function
Definition: A histone reader that specifically binds either to an unmodified histone H1 or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.
histone H3K56ac reader activity (GO:0140129)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 acetylated at lysine 56.
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2AK5ac reader activity (GO:0140130)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H2A acetylated at lysine 5.
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Corresponds to H2AK4 in yeast and in flies. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
positive regulation of lymphocyte chemotaxis (GO:0140131)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.
obsolete symbiont-mediated suppression of host cytokine production (GO:0140133)
Namespace: biological_process
Definition: OBSOLETE. A process by which a symbiont inhibits or disrupts cytokine production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: negative regulation by symbiont of host cytokine production; suppression by symbiont of host cytokine production; suppression by symbiont of host cytokine secretion
Comment: This term was obsoleted because it represents a readout.
venom-mediated perturbation of blood circulation (GO:0140134)
Namespace: biological_process
Definition: A process in which an organism alters or subverts the circulation of blood in another organism via the action of a venom.
Synonyms: venom-mediated perturbation of cardiovascular system; venom-mediated perturbation of circulatory system process
mechanosensitive monoatomic cation channel activity (GO:0140135)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress.
Synonyms: mechanically-gated cation channel activity; mechanosensitive cation channel activity
venom-mediated perturbation of muscle system process (GO:0140137)
Namespace: biological_process
Definition: A process in which an organism alters or subverts a muscular process in another organism via the action of a venom.
venom-mediated disruption of anatomical structure in another organism (GO:0140138)
Namespace: biological_process
Definition: A process by which an organism effects a change that impairs the structure or function of an anatomical structure in another organism via the action of a venom. Venoms are injected into the prey by a bite or a sting.
solid phase of basement membrane (GO:0140139)
Namespace: cellular_component
Definition: The solid compartment of the basement membrane ECM, including a specific subset of basement membrane collagens and basement membrane glycoproteins like laminins or nidogens.
mitochondrial guanine nucleotide transmembrane transport (GO:0140140)
Namespace: biological_process
Definition: The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial potassium ion transmembrane transport (GO:0140141)
Namespace: biological_process
Definition: The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
nucleocytoplasmic carrier activity (GO:0140142)
Namespace: molecular_function
Definition: Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein.
Synonyms: miRNA transporter activity; nucleocytoplasmic importin/exportin activity; pre-miRNA transporter activity
collagenous component of basement membrane (GO:0140143)
Namespace: cellular_component
Definition: Collagenous component of basement membrane ECMs, including collagen IV and other types of collagen specifically expressed in basement membrane.
non-collagenous component of basement membrane (GO:0140144)
Namespace: cellular_component
Definition: The non-collagenous compartment of the solid phase in basement membrane ECM, including glycoproteins like laminins or nidogens.
copper ion export from vacuole (GO:0140145)
Namespace: biological_process
Definition: The directed movement of copper ions out of the vacuole across the vacuolar membrane.
calcium ion import into vacuole (GO:0140146)
Namespace: biological_process
Definition: The directed movement of calcium cations into the vacuole across the vacuolar membrane.
zinc ion export from vacuole (GO:0140147)
Namespace: biological_process
Definition: The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol.
non-collagenous component of interstitial matrix (GO:0140149)
Namespace: cellular_component
Definition: The non-collagenous component of interstitial extracellular matrices, including glycoprotein like fibronectin and elastin.
gel phase of interstitial matrix (GO:0140150)
Namespace: cellular_component
Definition: Hydrogel filling the interstitial extracellular matrix space. Composed of proteoglycans such as hyaluronan and lectin-binding proteoglycans, SPOCK proteoglycans and small leucin-rich proteoglycan (SLRP).
solid phase of interstitial matrix (GO:0140151)
Namespace: cellular_component
Definition: The solid compartment of the interstitial matrix, including interstitial collagens such as fibrillar and fibril-associated collagens and non-collagenous glycoproteins like fibronectin and elastin.
collagenous component of interstitial matrix (GO:0140152)
Namespace: cellular_component
Definition: Main components of the interstitial matrix solid phase, including fibrillar and fibril-associated collagens.
FACIT collagen complex (GO:0140153)
Namespace: cellular_component
Definition: A supramolecular complex formed by fibril-associated collagens with interrupted triple helices (FACIT) that associate with collagen fibrils and forms a link on large, banded fibrils.
chicken-wire-like collagen network (GO:0140154)
Namespace: cellular_component
Definition: Network-forming collagens can either form a chicken-wire-like network or a hexagonal network. Collagen type IV forms a chicken-wire-like structure and is found in the basement membrane.
obsolete hexagonal collagen network of basement membrane (GO:0140155)
Namespace: cellular_component
Definition: OBSOLETE. Supramolecular structure formed by trimers of collagen VIII and found in the basement membrane.
Comment: This term was obsoleted because it is an uncessary grouping term. There is not sufficient evidence to show that collagen VIII is only located in the basement membrane in all organs and species.
multiplexin collagen trimer (GO:0140156)
Namespace: cellular_component
Definition: Collagen that contains multiple triple-helix domains with interruptions.
ammonium import across plasma membrane (GO:0140157)
Namespace: biological_process
Definition: The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol.