LiteFold/GO huggingface dataset:
peptidyl-arginine deglycation (GO:0036527)
Namespace: biological_process
Definition: The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein.
Synonyms: deglycation of N-acetylarginine
peptidyl-lysine deglycation (GO:0036528)
Namespace: biological_process
Definition: The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein.
Synonyms: deglycation of N-acetyllysine
protein deglycation, glyoxal removal (GO:0036529)
Namespace: biological_process
Definition: The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein.
Synonyms: protein deglycation of glyoxal-glycated protein
protein deglycation, methylglyoxal removal (GO:0036530)
Namespace: biological_process
Definition: The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein.
Synonyms: protein deglycation of methylglyoxal-glycated protein
obsolete glutathione deglycation (GO:0036531)
Namespace: biological_process
Definition: OBSOLETE. The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine.
Comment: The reason for obsoletion is that this term represents a molecular function.
paracrine signaling (GO:0038001)
Namespace: biological_process
Definition: The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.
Synonyms: paracrine signalling
Comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from endocrine signaling.
endocrine signaling (GO:0038002)
Namespace: biological_process
Definition: The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other.
Synonyms: endocrine signalling
Comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from paracrine signaling.
G protein-coupled opioid receptor signaling pathway (GO:0038003)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: opioid receptor signaling pathway; opioid receptor signalling pathway
epidermal growth factor receptor ligand maturation (GO:0038004)
Namespace: biological_process
Definition: Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.
Synonyms: EGFR ligand maturation; EGFR ligand maturation by peptide bond cleavage; EGFR ligand processing; epidermal growth factor receptor ligand processing; peptide bond cleavage involved in EGFR ligand maturation; peptide bond cleavage involved in epidermal growth factor receptor ligand maturation
netrin receptor activity involved in chemoattraction (GO:0038006)
Namespace: molecular_function
Definition: Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin.
Synonyms: attractive netrin receptor activity; netrin receptor activity involved in positive chemotaxis
netrin-activated signaling pathway (GO:0038007)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
Synonyms: netrin signaling pathway; netrin-activated signal transduction pathway; netrin-activated signalling pathway; netrin-mediated signaling pathway
obsolete TRAF-mediated signal transduction (GO:0038008)
Namespace: biological_process
Definition: OBSOLETE. The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components.
Synonyms: TRAF signaling; TRAF-mediated intracellular signaling; TRAF-mediated signaling; TRAF-mediated signalling; tumor necrosis factor receptor-associated factor signal transduction; tumor necrosis factor receptor-associated factor signaling
Comment: This term was obsoleted because it represents an activity present in multiple different pathways.
regulation of signal transduction by receptor internalization (GO:0038009)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.
Synonyms: regulation of signaling pathway by receptor endocytosis
positive regulation of signal transduction by receptor internalization (GO:0038010)
Namespace: biological_process
Definition: Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms.
Synonyms: positive regulation of signaling pathway by receptor endocytosis
negative regulation of signal transduction by receptor internalization (GO:0038011)
Namespace: biological_process
Definition: Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands.
Synonyms: negative regulation of signaling pathway by receptor endocytosis
obsolete negative regulation of Wnt signaling pathway by Wnt receptor internalization (GO:0038012)
Namespace: biological_process
Definition: OBSOLETE. Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction.
Synonyms: ligand-dependent internalization of Frizzled; negative regulation of Wnt receptor signaling pathway by Wnt receptor endocytosis; negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization; negative regulation of Wnt receptor signalling pathway by Wnt receptor internalization; negative regulation of Wnt-activated signaling pathway by Wnt receptor internalization
Comment: This term was obsoleted because it represents a GO-CAM model.
negative regulation of insulin receptor signaling pathway by insulin receptor internalization (GO:0038014)
Namespace: biological_process
Definition: Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation.
Synonyms: agonist-stimulated insulin receptor internalization; negative regulation of insulin receptor signalling pathway by insulin receptor internalization
positive regulation of insulin receptor signaling pathway by insulin receptor internalization (GO:0038015)
Namespace: biological_process
Definition: Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane.
Synonyms: positive regulation of insulin receptor signalling pathway by insulin receptor internalization
insulin receptor internalization (GO:0038016)
Namespace: biological_process
Definition: A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell.
Synonyms: insulin receptor endocytosis
Wnt receptor internalization (GO:0038017)
Namespace: biological_process
Definition: A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell.
Synonyms: Wnt receptor endocytosis
Wnt receptor catabolic process (GO:0038018)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.
Synonyms: Frizzled degradation; negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation; Wnt receptor breakdown; Wnt receptor catabolism; Wnt receptor degradation
Wnt receptor recycling (GO:0038019)
Namespace: biological_process
Definition: The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.
Synonyms: Frizzled recycling
insulin receptor recycling (GO:0038020)
Namespace: biological_process
Definition: The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.
leptin receptor activity (GO:0038021)
Namespace: molecular_function
Definition: Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
G protein-coupled olfactory receptor activity (GO:0038022)
Namespace: molecular_function
Definition: Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G-protein coupled odorant receptor activity; G-protein coupled olfactory receptor activity; odorant receptor activity, G-protein coupled; olfactory receptor activity, G-protein coupled
signaling receptor activity (GO:0038023)
Namespace: molecular_function
Definition: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
Synonyms: receptor activity; receptor activity involved in signal transduction; signalling receptor activity
cargo receptor activity (GO:0038024)
Namespace: molecular_function
Definition: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.
Synonyms: endocytic receptor activity; receptor activity; receptor activity involved in receptor-mediated endocytosis; transport receptor activity
Comment: Notes: (1) For receptors binding a molecule but coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857'.
reelin-mediated signaling pathway (GO:0038026)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: reeler-mediated signaling pathway; reelin-mediated signal transduction pathway; reelin-mediated signalling pathway
apolipoprotein A-I-mediated signaling pathway (GO:0038027)
Namespace: biological_process
Definition: The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: apolipoprotein A-I-mediated signalling pathway
obsolete insulin receptor signaling pathway via phosphatidylinositol 3-kinase (GO:0038028)
Namespace: biological_process
Definition: OBSOLETE. An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade.
Synonyms: insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; insulin receptor signaling pathway via PI3K cascade; insulin receptor signaling via PI3K; insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade
Comment: The reason for obsoletion is that insulin signaling activates the PI3K/PKB pathway (see Fig 3 in PMID:34274528), so this term is redundant with GO:0008286 insulin receptor signaling pathway.
obsolete epidermal growth factor receptor signaling pathway via MAPK cascade (GO:0038029)
Namespace: biological_process
Definition: OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal is transmitted via the MAPKKK cascade.
Synonyms: EGFR signaling pathway via MAPKKK cascade; EGFR signaling via MAPKKK cascade; EGFR/MAPK signaling; epidermal growth factor receptor signaling pathway via MAPKKK cascade; epidermal growth factor receptor signalling pathway via MAPKKK cascade
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete non-canonical Wnt signaling pathway via JNK cascade (GO:0038031)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade.
Synonyms: non-canonical Wnt receptor signaling pathway via JNK cascade; non-canonical Wnt receptor signalling pathway via JNK cascade; non-canonical Wnt-activated signaling pathway via JNK cascade
Comment: This term was obsoleted because it represents a GO-CAM model.
termination of G protein-coupled receptor signaling pathway (GO:0038032)
Namespace: biological_process
Definition: The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal.
Synonyms: termination of G-protein coupled receptor signaling pathway; termination of G-protein coupled receptor signalling pathway; termination of GPCR signaling pathway
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway (GO:0038033)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
Synonyms: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway; positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway; vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis; VEGF-mediated chemotactic endothelial cell migration; VEGF-VEGFR-induced endothelial cell chemotaxis
signal transduction in absence of ligand (GO:0038034)
Namespace: biological_process
Definition: The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.
Synonyms: addiction receptor signaling pathway; basal signaling; dependence receptor signaling pathway; negative signal transduction; non-classical signal transduction; signal transduction in absence of agonist
ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0038035)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway in which the receptor constitutively activates adenylate cyclase, without binding to an agonist.
Synonyms: basal G-protein coupled receptor signaling; G protein-coupled receptor signaling in absence of ligand; G-protein coupled receptor signaling in absence of agonist; G-protein coupled receptor signaling in absence of ligand; G-protein coupled receptor signalling in absence of ligand
sphingosine-1-phosphate receptor activity (GO:0038036)
Namespace: molecular_function
Definition: Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein.
Synonyms: S1P receptor activity
G protein-coupled receptor dimeric complex (GO:0038037)
Namespace: cellular_component
Definition: A protein complex that contains two G protein-coupled receptors.
Synonyms: G-protein coupled receptor dimer; G-protein coupled receptor dimeric complex; GPCR dimer
G protein-coupled receptor homodimeric complex (GO:0038038)
Namespace: cellular_component
Definition: A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.
Synonyms: G-protein coupled receptor homodimer; G-protein coupled receptor homodimeric complex; GPCR homodimer
obsolete cross-receptor activation within G-protein coupled receptor heterodimer (GO:0038040)
Namespace: biological_process
Definition: OBSOLETE. Activation of one protomer of a consequence of a G protein-coupled (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter.
Comment: This term was obsoleted because it should be captured as a GO-CAM model.
cross-receptor inhibition within G protein-coupled receptor heterodimer (GO:0038041)
Namespace: biological_process
Definition: Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit.
Synonyms: cross-receptor inhibition within G-protein coupled receptor heterodimer
interleukin-5-mediated signaling pathway (GO:0038043)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-5-mediated signaling pathway; interleukin-5-mediated signalling pathway
large latent transforming growth factor-beta complex (GO:0038045)
Namespace: cellular_component
Definition: A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.
Synonyms: large latent complex; LLC
G protein-coupled enkephalin receptor activity (GO:0038046)
Namespace: molecular_function
Definition: Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.
Synonyms: delta-opioid receptor activity; enkephalin receptor activity
morphine receptor activity (GO:0038047)
Namespace: molecular_function
Definition: Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.
Synonyms: mu-opioid receptor activity
dynorphin receptor activity (GO:0038048)
Namespace: molecular_function
Definition: Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin.
Synonyms: kappa-opioid receptor activity
obsolete transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding (GO:0038053)
Namespace: molecular_function
Definition: OBSOLETE. Combining with estrogen and transmitting the signal to the transcriptional machinery by binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements.
Synonyms: estrogen nuclear receptor activity; estrogen-activated RNA polymerase II transcription factor binding transcription factor activity
Comment: This term was obsoleted because it represents a GO-CAM model.
G protein-coupled estrogen receptor activity (GO:0038054)
Namespace: molecular_function
Definition: Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: estrogen receptor activity; G-protein coupled estrogen receptor activity
BMP secretion (GO:0038055)
Namespace: biological_process
Definition: The controlled release of a member of the BMP family of proteins from a cell.
Synonyms: BMP protein secretion; bone morphogenetic protein secretion
obsolete negative regulation of BMP signaling pathway by negative regulation of BMP secretion (GO:0038056)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell.
Synonyms: negative regulation of BMP signaling pathway by negative regulation of bone morphogenetic protein secretion; negative regulation of BMP signalling pathway by negative regulation of BMP secretion
Comment: This term was obsoleted because it represents a GO-CAM model.
TNFSF11 binding (GO:0038057)
Namespace: molecular_function
Definition: Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family.
Synonyms: CD254 binding; ODF binding; OPGL binding; osteoclast differentiation factor binding; osteoprotegerin ligand binding; RANKL binding; receptor activator of nuclear factor kappa-B ligand binding; TNF-related activation-induced cytokine binding; TRANCE binding; tumor necrosis factor (ligand) superfamily member 11 binding; tumor necrosis factor ligand superfamily member 11 binding; tumor necrosis factor superfamily member 11 binding