LiteFold/GO huggingface dataset:
structural constituent of postsynaptic actin cytoskeleton (GO:0098973)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton.
postsynaptic actin cytoskeleton organization (GO:0098974)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
postsynapse of neuromuscular junction (GO:0098975)
Namespace: cellular_component
Definition: The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.
excitatory chemical synaptic transmission (GO:0098976)
Namespace: biological_process
Definition: Synaptic transmission that results in an excitatory postsynaptic potential.
inhibitory chemical synaptic transmission (GO:0098977)
Namespace: biological_process
Definition: Synaptic transmission that results in an inhibitory postsynaptic potential.
glutamatergic synapse (GO:0098978)
Namespace: cellular_component
Definition: A synapse that uses glutamate as a neurotransmitter.
polyadic synapse (GO:0098979)
Namespace: cellular_component
Definition: A synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems.
presynaptic density (GO:0098980)
Namespace: cellular_component
Definition: An electron dense specialization of the presynaptic active zone cytoskeleton.
cholinergic synapse (GO:0098981)
Namespace: cellular_component
Definition: A synapse that uses acetylcholine as a neurotransmitter.
GABA-ergic synapse (GO:0098982)
Namespace: cellular_component
Definition: A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
symmetric, GABA-ergic, inhibitory synapse (GO:0098983)
Namespace: cellular_component
Definition: A neuron to neuron synapse that lacks an electron dense postsynaptic specialization, uses GABA as a neurotransmitter and whose activity results in inhibitory postsynaptic potentials.
asymmetric, glutamatergic, excitatory synapse (GO:0098985)
Namespace: cellular_component
Definition: A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials.
T-bar (GO:0098986)
Namespace: cellular_component
Definition: A T-shaped presynpatic density. These are common in arhropod central nervous systems.
regulation of modification of synapse structure, modulating synaptic transmission (GO:0098987)
Namespace: biological_process
Definition: Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
G protein-coupled glutamate receptor activity (GO:0098988)
Namespace: molecular_function
Definition: Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity.
Synonyms: G-protein coupled glutamate receptor activity
NMDA selective glutamate receptor signaling pathway (GO:0098989)
Namespace: biological_process
Definition: The series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
AMPA selective glutamate receptor signaling pathway (GO:0098990)
Namespace: biological_process
Definition: The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
kainate selective glutamate receptor signaling pathway (GO:0098991)
Namespace: biological_process
Definition: The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription.
neuronal dense core vesicle (GO:0098992)
Namespace: cellular_component
Definition: A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.
obsolete anchored component of synaptic vesicle membrane (GO:0098993)
Namespace: cellular_component
Definition: OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
symbiont entry into host cell via disruption of host cell envelope (GO:0098994)
Namespace: biological_process
Definition: The disruption by a symbiont of host cell envelope components to allow entry into the host cell.
Synonyms: disruption of host cell envelope during viral entry
symbiont entry into host cell via disruption of host cell glycocalyx (GO:0098996)
Namespace: biological_process
Definition: The disruption by a symbiont of host cell capsule to allow entry into the host cell.
Synonyms: catabolism of host glycocalyx during viral entry; degradation of host capsule during virus entry; degradation of host glycocalyx during viral entry; disassembly of glycocalyx during viral entry; disruption of host cell glycocalyx during viral entry; symbiont entry into host cell by disruption of host cell capsule
fusion of virus membrane with host outer membrane (GO:0098997)
Namespace: biological_process
Definition: Fusion of a viral membrane with the host cell outer membrane during viral entry.
Synonyms: fusion of viral membrane with host outer membrane; viral envelope fusion; viral envelope fusion with host outer membrane; viral penetration via membrane fusion; viral-cell fusion molecule activity
extrinsic component of postsynaptic early endosome membrane (GO:0098998)
Namespace: cellular_component
Definition: The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of postsynaptic endosome membrane (GO:0098999)
Namespace: cellular_component
Definition: The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
symbiont genome ejection through host cell envelope, contractile tail mechanism (GO:0099000)
Namespace: biological_process
Definition: Entry of a symbiont's genome into the host cell through the host cell envelope via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. Occurs in non-enveloped prokaryotic viruses.
Synonyms: viral contractile tail ejection system; viral genome ejection through host cell envelope, contractile tail mechanism
symbiont genome ejection through host cell envelope, long flexible tail mechanism (GO:0099001)
Namespace: biological_process
Definition: Entry of a symbiont's genome into the host cell through the host cell envelope via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm. Occurs in non-enveloped prokaryotic viruses.
Synonyms: viral genome ejection through host cell envelope, long flexible tail mechanism; viral long flexible tail ejection system
symbiont genome ejection through host cell envelope, short tail mechanism (GO:0099002)
Namespace: biological_process
Definition: Entry of a symbiont's genome into the host cell through the host cell envelope via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties. Occurs in non-enveloped prokaryotic viruses.
Synonyms: viral genome ejection through host cell envelope, short tail mechanism; viral short tail ejection system
vesicle-mediated transport in synapse (GO:0099003)
Namespace: biological_process
Definition: Any vesicle-mediated transport that occurs in a synapse.
obsolete calmodulin dependent kinase signaling pathway (GO:0099004)
Namespace: biological_process
Definition: OBSOLETE. Any signal transduction pathway involving calmodulin dependent kinase activity.
Synonyms: CAMK signaling pathway
Comment: This term was obsoleted because it does not represent a defined siagnling pathway.
extrinsic component of postsynaptic recycling endosome membrane (GO:0099005)
Namespace: cellular_component
Definition: The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
symbiont entry into host cell via permeabilization of endosomal membrane (GO:0099006)
Namespace: biological_process
Definition: The entry of a symbiont into a host cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) of the symbiont. This process mediates the entry of some non-enveloped virus into eukaryotic cells. In some cases, viral membrane-penetration protein requires to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen.
Synonyms: viral entry via permeabilization of endosomal membrane
extrinsic component of presynaptic endosome membrane (GO:0099007)
Namespace: cellular_component
Definition: The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
symbiont entry into host cell via permeabilization of inner membrane (GO:0099008)
Namespace: biological_process
Definition: The entry of a symbiont into the cytoplasm of a host cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. This process mediates the entry of some non-enveloped viruses into prokaryotic cells. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization and permeabilization of the plasma membrane.
Synonyms: viral entry via permeabilization of inner membrane
viral genome circularization (GO:0099009)
Namespace: biological_process
Definition: The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities.
modification of postsynaptic structure (GO:0099010)
Namespace: biological_process
Definition: Any process that modifies the structure of a postsynapse.
Synonyms: synapse remodelling
Comment: This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones.
neuronal dense core vesicle exocytosis (GO:0099011)
Namespace: biological_process
Definition: The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels.
neuronal dense core vesicle membrane (GO:0099012)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a neuronal dense core vesicle.
neuronal dense core vesicle lumen (GO:0099013)
Namespace: cellular_component
Definition: The volume enclosed by a neuronal dense core vesicle membrane.
neuronal dense core vesicle organization (GO:0099014)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle.
degradation of host chromosome by virus (GO:0099015)
Namespace: biological_process
Definition: The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis.
symbiont-mediated evasion of DNA end degradation by host (GO:0099016)
Namespace: biological_process
Definition: A process by which a symbiont evades and ends degradation of its DNA when free DNA ends are exposed. DNA ends are exposed during the life cycle of some viruses and these are targeted by host cells to destroy the virus. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases.
Synonyms: DNA end degradation evasion by virus; evasion by virus of DNA end degradation; evasion of DNA end degradation by host
maintenance of protein localization at cell tip (GO:0099017)
Namespace: biological_process
Definition: Any process in which localization of a protein is maintained at the cell tip.
Synonyms: maintenance of protein location at cell tip
symbiont-mediated evasion of host restriction-modification system (GO:0099018)
Namespace: biological_process
Definition: A process by which a symbiont evades the DNA restriction modification system of its host. This process occurs in phages to protein themselves from bacterial restriction enzyme systems. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restriction enzymes while some use unusual bases in their genome to avoid restriction.
Synonyms: evasion by virus of host restriction-modification system; evasion of host restriction-modification system; restriction-modification system evasion by virus
maintenance of protein localization at growing cell tip (GO:0099019)
Namespace: biological_process
Definition: Any process in which localization of a protein is maintained at the growing cell tip.
Synonyms: maintenance of protein location at growing cell tip
perinuclear endoplasmic reticulum lumen (GO:0099020)
Namespace: cellular_component
Definition: The volume enclosed by the membranes of the perinuclear endoplasmic reticulum.
cortical endoplasmic reticulum lumen (GO:0099021)
Namespace: cellular_component
Definition: The volume enclosed by the membranes of the cortical endoplasmic reticulum.
vesicle tethering (GO:0099022)
Namespace: biological_process
Definition: The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.
vesicle tethering complex (GO:0099023)
Namespace: cellular_component
Definition: Any protein complex that plays a role in vesicle tethering.
plasma membrane invagination (GO:0099024)
Namespace: biological_process
Definition: An infolding of the plasma membrane.
obsolete anchored component of postsynaptic membrane (GO:0099025)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of presynaptic membrane (GO:0099026)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Synonyms: anchored component of presynaptic plasma membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of presynaptic endocytic zone membrane (GO:0099027)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of presynaptic active zone membrane (GO:0099029)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of postsynaptic specialization membrane (GO:0099030)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of postsynaptic density membrane (GO:0099031)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of postsynaptic early endosome membrane (GO:0099032)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of postsynaptic recycling endosome membrane (GO:0099033)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of spine apparatus membrane (GO:0099035)
Namespace: cellular_component
Definition: OBSOLETE. The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of neuronal dense core vesicle membrane (GO:0099036)
Namespace: cellular_component
Definition: OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of presynaptic endosome membrane (GO:0099037)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
ceramide floppase activity (GO:0099038)
Namespace: molecular_function
Definition: Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: ATP-dependent ceramide transporter activity; ATPase-coupled ceramide transporter activity; ceramide floppase activity (cytosolic to exoplasmic leaflet); ceramide-translocating ATPase activity
sphingolipid translocation (GO:0099039)
Namespace: biological_process
Definition: The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
obsolete nucleation of clathrin-coated pit (GO:0099042)
Namespace: biological_process
Definition: OBSOLETE. The first step in clathrin-dependent endocytosis: invagination of the plasma membrane to form a pit.
Comment: The reason for obsoletion is this term is describing a process similar to that of clathrin coat assembly.
obsolete cargo loading involved in clathrin-dependent endocytosis (GO:0099043)
Namespace: biological_process
Definition: OBSOLETE. Formation of a macromolecular complex during clathrin-dependent endocytosis that connects the assembling clathrin coat to the proteins and/or lipoproteins to be transported in an endocytic vesicle. This complex includes a receptor and an adaptor protein that links the receptor to the clathrin coat.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.