LiteFold/GO huggingface dataset:
positive regulation of thrombin-activated receptor signaling pathway (GO:0070496)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
Synonyms: positive regulation of thrombin receptor signaling pathway; positive regulation of thrombin receptor signalling pathway
6-carboxytetrahydropterin synthase activity (GO:0070497)
Namespace: molecular_function
Definition: Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+.
Synonyms: 6-carboxy-5,6,7,8-tetrahydropterin synthase activity
interleukin-1-mediated signaling pathway (GO:0070498)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-1 alpha-mediated signaling pathway; IL-1 beta-mediated signaling pathway; IL-1-mediated signaling pathway; interleukin-1 alpha-mediated signaling pathway; interleukin-1 beta-mediated signaling pathway; interleukin-1-mediated signalling pathway
exosporium assembly (GO:0070499)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore.
Synonyms: exosporium formation
obsolete poly-gamma-glutamate metabolic process (GO:0070500)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds.
Synonyms: poly-gamma-glutamate metabolism
Comment: This term was obsoleted because it represents a molecular function.
poly-gamma-glutamate biosynthetic process (GO:0070501)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds.
Synonyms: poly-gamma-glutamate anabolism; poly-gamma-glutamate biosynthesis; poly-gamma-glutamate formation; poly-gamma-glutamate synthesis
capsule poly-gamma-glutamate biosynthetic process (GO:0070502)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule.
Synonyms: capsular poly-gamma-glutamate biosynthetic process; capsule poly-gamma-glutamate anabolism; capsule poly-gamma-glutamate biosynthesis; capsule poly-gamma-glutamate formation; capsule poly-gamma-glutamate synthesis
obsolete selenium-containing prosthetic group metabolic process (GO:0070503)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments.
Synonyms: selenium-containing prosthetic group metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
pollen coat (GO:0070505)
Namespace: cellular_component
Definition: A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma.
Synonyms: pollenkitt; tryphine
high-density lipoprotein particle receptor activity (GO:0070506)
Namespace: molecular_function
Definition: Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis.
Synonyms: HDL receptor; high-density lipoprotein receptor activity
regulation of microtubule cytoskeleton organization (GO:0070507)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
Synonyms: regulation of microtubule cytoskeleton organisation; regulation of microtubule dynamics
calcium ion import (GO:0070509)
Namespace: biological_process
Definition: The directed movement of calcium ions into a cell or organelle.
Synonyms: calcium ion uptake; transmembrane calcium influx
obsolete regulation of histone H4-K20 methylation (GO:0070510)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4.
Comment: This term was obsoleted because it represents regulation of a molecular function.
death domain binding (GO:0070513)
Namespace: molecular_function
Definition: Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.
Comment: For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'.
SRF-myogenin-E12 complex (GO:0070514)
Namespace: cellular_component
Definition: A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.
alphaIIb-beta3 integrin-talin complex (GO:0070515)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin.
Synonyms: ITGA2b-ITGB3-TLN1 complex
CAK-ERCC2 complex (GO:0070516)
Namespace: cellular_component
Definition: A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.
Synonyms: cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex
DNA replication factor C core complex (GO:0070517)
Namespace: cellular_component
Definition: A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.
Synonyms: RFC core complex
alpha4-beta1 integrin-CD53 complex (GO:0070518)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.
Synonyms: ITGA4-ITGB1-CD53 complex
alpha4-beta1 integrin-CD63 complex (GO:0070519)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
Synonyms: ITGA4-ITGB1-CD63 complex
alpha4-beta1 integrin-CD81 complex (GO:0070520)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family.
Synonyms: ITGA4-ITGB1-CD81 complex
alpha4-beta1 integrin-CD82 complex (GO:0070521)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family.
ERCC4-ERCC1 complex (GO:0070522)
Namespace: cellular_component
Definition: A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae.
Synonyms: Rad1-Rad10 complex; XPF-ERCC1 complex
Comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
11-beta-hydroxysteroid dehydrogenase (NAD+) activity (GO:0070523)
Namespace: molecular_function
Definition: Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+.
11-beta-hydroxysteroid dehydrogenase (NADP+) activity (GO:0070524)
Namespace: molecular_function
Definition: Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+.
Synonyms: beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase activity
tRNA threonylcarbamoyladenosine metabolic process (GO:0070525)
Namespace: biological_process
Definition: The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.
Synonyms: t6A metabolic process; t6A metabolism; threonylcarbamoyladenosine metabolism
platelet aggregation (GO:0070527)
Namespace: biological_process
Definition: The adhesion of one platelet to one or more other platelets via adhesion molecules.
Synonyms: blood platelet aggregation; thrombocyte aggregation
protein kinase C signaling (GO:0070528)
Namespace: biological_process
Definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
Synonyms: PKC signal transduction; PKC signaling cascade; protein kinase C signal transduction; protein kinase C signaling cascade; protein kinase C signalling cascade
obsolete L-tryptophan transaminase activity (GO:0070529)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid.
Synonyms: L-tryptophan aminotransferase activity
Comment: This term was obsoleted because it is an unnecessary grouping term.
K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)
Namespace: molecular_function
Definition: Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.
BRCA1-A complex (GO:0070531)
Namespace: cellular_component
Definition: A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
BRCA1-B complex (GO:0070532)
Namespace: cellular_component
Definition: A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.
BRCA1-C complex (GO:0070533)
Namespace: cellular_component
Definition: A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.
obsolete histone H2A K63-linked ubiquitination (GO:0070535)
Namespace: biological_process
Definition: OBSOLETE. A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX.
Comment: This term was obsoleted because it represents a molecular function.
protein K63-linked deubiquitination (GO:0070536)
Namespace: biological_process
Definition: A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.
obsolete histone H2A K63-linked deubiquitination (GO:0070537)
Namespace: biological_process
Definition: OBSOLETE. A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX.
Comment: This term was obsoleted because it represents a molecular function.
oleic acid binding (GO:0070538)
Namespace: molecular_function
Definition: Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.
linoleic acid binding (GO:0070539)
Namespace: molecular_function
Definition: Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.
stearic acid binding (GO:0070540)
Namespace: molecular_function
Definition: Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid.
response to platinum ion (GO:0070541)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus.
Synonyms: response to platinum
response to fatty acid (GO:0070542)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
response to linoleic acid (GO:0070543)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.
Synonyms: response to linoleate
obsolete histone H3-K36 demethylation (GO:0070544)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.
Synonyms: H3K36 demethylation
Comment: This term was obsoleted because it represents a molecular function.
PeBoW complex (GO:0070545)
Namespace: cellular_component
Definition: A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.
obsolete L-phenylalanine transaminase activity (GO:0070546)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid.
Synonyms: L-phenylalanine aminotransferase activity
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete L-tyrosine aminotransferase activity (GO:0070547)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete L-glutamine transaminase activity (GO:0070548)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid.
Synonyms: L-glutamine aminotransferase activity
Comment: This term was obsoleted because it is too general. Consider other glutamine transaminase activity terms.
siRNA-mediated gene silencing by inhibition of translation (GO:0070549)
Namespace: biological_process
Definition: An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs.
Synonyms: down regulation of translation involved in RNA interference; down-regulation of translation involved in RNA interference; downregulation of translation involved in RNA interference; inhibition of translation involved in RNA interference; negative regulation of translation involved in RNA interference; RNA interference, negative regulation of translation
rDNA chromatin condensation (GO:0070550)
Namespace: biological_process
Definition: The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase.
Synonyms: rDNA condensation; rDNA packaging
endoribonuclease activity, cleaving siRNA-paired mRNA (GO:0070551)
Namespace: molecular_function
Definition: Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.
Synonyms: argonaute endoribonuclease activity
BRISC complex (GO:0070552)
Namespace: cellular_component
Definition: A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.
nicotinic acid receptor activity (GO:0070553)
Namespace: molecular_function
Definition: Combining with nicotinic acid to initiate a change in cell activity.
Synonyms: niacin receptor activity
synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex (GO:0070554)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof).
Synonyms: SNARE complex (Stx3, Snap25, Vamp2, Cplx1); Stx3-Snap25-Vamp2-Cplx1 complex
response to interleukin-1 (GO:0070555)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
Synonyms: response to IL-1
TAF4B-containing transcription factor TFIID complex (GO:0070556)
Namespace: cellular_component
Definition: A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.
Synonyms: TFIID complex, B-cell specific
PCNA-p21 complex (GO:0070557)
Namespace: cellular_component
Definition: A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.
alphaM-beta2 integrin-CD63 complex (GO:0070558)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
Synonyms: ITGAM-ITGB2-CD63 complex
protein secretion by platelet (GO:0070560)
Namespace: biological_process
Definition: The regulated release of proteins by a platelet or group of platelets.
vitamin D receptor signaling pathway (GO:0070561)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by vitamin D binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: calcitriol signaling pathway; intracellular vitamin D receptor signaling pathway; nuclear receptor-mediated vitamin D signaling pathway; VDR signaling pathway; vitamin D receptor signalling pathway
regulation of vitamin D receptor signaling pathway (GO:0070562)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity.
Synonyms: regulation of VDR signaling pathway; regulation of vitamin D receptor signalling pathway
negative regulation of vitamin D receptor signaling pathway (GO:0070563)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity.
Synonyms: down regulation of vitamin D receptor signaling pathway; down-regulation of vitamin D receptor signaling pathway; downregulation of vitamin D receptor signaling pathway; inhibition of vitamin D receptor signaling pathway; negative regulation of VDR signaling pathway; negative regulation of VDR signalling pathway; negative regulation vitamin D receptor signalling pathway
positive regulation of vitamin D receptor signaling pathway (GO:0070564)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity.
Synonyms: activation of vitamin D receptor signaling pathway; positive regulation of VDR signaling pathway; positive regulation of vitamin D receptor signalling pathway; stimulation of vitamin D receptor signaling pathway; up regulation of vitamin D receptor signaling pathway; up-regulation of vitamin D receptor signaling pathway; upregulation of vitamin D receptor signaling pathway
telomere-telomerase complex (GO:0070565)
Namespace: cellular_component
Definition: A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome.
Comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
adenylyltransferase activity (GO:0070566)
Namespace: molecular_function
Definition: Catalysis of the transfer of an adenylyl group to an acceptor.
cytidylyltransferase activity (GO:0070567)
Namespace: molecular_function
Definition: Catalysis of the transfer of a cytidylyl group to an acceptor.
uridylyltransferase activity (GO:0070569)
Namespace: molecular_function
Definition: Catalysis of the transfer of an uridylyl group to an acceptor.
Synonyms: uridyl transferase activity; uridyltransferase activity
regulation of neuron projection regeneration (GO:0070570)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.
negative regulation of neuron projection regeneration (GO:0070571)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.
Synonyms: growth cone collapse
positive regulation of neuron projection regeneration (GO:0070572)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.
metallodipeptidase activity (GO:0070573)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms: metallo-exo-dipeptidase activity; metalloexodipeptidase activity
cadmium ion transmembrane transport (GO:0070574)
Namespace: biological_process
Definition: A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
Synonyms: cadmium ion membrane transport; transmembrane cadmium transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
vitamin D 24-hydroxylase activity (GO:0070576)
Namespace: molecular_function
Definition: Catalysis of the hydroxylation of C-24 of any form of vitamin D.
Synonyms: calciferol 24-hydroxylase activity; cholecalciferol 24-hydroxylase activity; ergocalciferol 24-hydroxylase activity; vitamin D2 24-hydroxylase activity; vitamin D3 24-hydroxylase activity