LiteFold/GO huggingface dataset:
positive regulation of leukotriene production involved in inflammatory response (GO:0035491)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.
obsolete negative regulation of leukotriene production involved in inflammatory response (GO:0035492)
Namespace: biological_process
Definition: OBSOLETE. Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
SNARE complex assembly (GO:0035493)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
SNARE complex disassembly (GO:0035494)
Namespace: biological_process
Definition: The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
regulation of SNARE complex disassembly (GO:0035495)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
lipopolysaccharide-1,5-galactosyltransferase activity (GO:0035496)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide.
Synonyms: LPS-1,5-galactosyltransferase activity; UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase
cAMP response element binding (GO:0035497)
Namespace: molecular_function
Definition: Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
Synonyms: cAMP-responsive element binding; CRE binding; cyclic AMP response element binding; cyclic-AMP response element binding; cyclic-AMP-responsive element binding
carnosine metabolic process (GO:0035498)
Namespace: biological_process
Definition: The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine).
Synonyms: carnosine metabolism
carnosine biosynthetic process (GO:0035499)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).
Synonyms: carnosine anabolism; carnosine biosynthesis; carnosine formation; carnosine synthesis
MH2 domain binding (GO:0035500)
Namespace: molecular_function
Definition: Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.
Synonyms: MAD homology 2 domain binding
MH1 domain binding (GO:0035501)
Namespace: molecular_function
Definition: Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.
Synonyms: MAD homology 1 domain binding
metanephric part of ureteric bud development (GO:0035502)
Namespace: biological_process
Definition: The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros.
ureter part of ureteric bud development (GO:0035503)
Namespace: biological_process
Definition: The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter.
obsolete regulation of myosin light chain kinase activity (GO:0035504)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of myosin light chain kinase activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete positive regulation of myosin light chain kinase activity (GO:0035505)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of myosin light chain kinase activity (GO:0035506)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete regulation of myosin-light-chain-phosphatase activity (GO:0035507)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity.
Comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
obsolete positive regulation of myosin-light-chain-phosphatase activity (GO:0035508)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.
Comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
obsolete negative regulation of myosin-light-chain-phosphatase activity (GO:0035509)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.
Comment: The reason for obsoletion is that this term represents a single-step process (regulation of MF).
obsolete oxidative DNA demethylation (GO:0035511)
Namespace: biological_process
Definition: OBSOLETE. Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
Comment: This term was obsoleted because it represents a molecular function.
obsolete hydrolytic DNA demethylation (GO:0035512)
Namespace: biological_process
Definition: OBSOLETE. The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule.
Comment: This term was obsoleted because it represents a molecular function.
oxidative RNA demethylation (GO:0035513)
Namespace: biological_process
Definition: The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms.
DNA demethylase activity (GO:0035514)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule.
oxidative RNA demethylase activity (GO:0035515)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
Synonyms: 2-oxoglutarate-dependent RNA demethylase
broad specificity oxidative DNA demethylase activity (GO:0035516)
Namespace: molecular_function
Definition: Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
Synonyms: 1-ethyladenine demethylase activity; 2-oxoglutarate-dependent DNA demethylase; 5-formylcytosine dioxygenase activity; 5-hydroxymethylcytosine dioxygenase activity; 5fC dioxygenase; 5hmC dioxygenase; N1-methyladenine demethylase activity; N3-methylcytosine demethylase activity; oxidative DNA demethylase activity
Comment: This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system.
PR-DUB complex (GO:0035517)
Namespace: cellular_component
Definition: A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.
Synonyms: Polycomb repressive deubiquitinase complex
obsolete histone H2A monoubiquitination (GO:0035518)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group.
Comment: This term was obsoleted because it represents a molecular function.
protein K29-linked ubiquitination (GO:0035519)
Namespace: biological_process
Definition: A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation.
Synonyms: protein K29-linked polyubiquitination
monoubiquitinated protein deubiquitination (GO:0035520)
Namespace: biological_process
Definition: The removal of the ubiquitin group from a monoubiquitinated protein.
Synonyms: monoubiquitinated protein deubiquitinylation; monoubiquitinated protein deubiquitylation
obsolete monoubiquitinated histone H2A deubiquitination (GO:0035522)
Namespace: biological_process
Definition: OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
Synonyms: monoubiquitinated histone H2A deubiquitinylation; monoubiquitinated histone H2A deubiquitylation
Comment: This term was obsoleted because it represents a molecular function.
proline transmembrane transport (GO:0035524)
Namespace: biological_process
Definition: The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore.
Synonyms: proline membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
NF-kappaB p50/p65 complex (GO:0035525)
Namespace: cellular_component
Definition: A heterodimer of NF-kappa B p50 and p65 subunits.
Synonyms: NF-kappa B1/p65 complex; NF-kappa B1/RelA complex; NF-kappa p105/p65 complex; NF-kappa p105/RelA complex; NF-kappa p50/RelA complex
Comment: Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.
retrograde transport, plasma membrane to Golgi (GO:0035526)
Namespace: biological_process
Definition: The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.
3-hydroxypropionate dehydrogenase (NADP+) activity (GO:0035527)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.
Synonyms: 3-hydroxypropanoate dehydrogenase (NADP+) activity; 3-hydroxypropanoate:NADP+ oxidoreductase; 3-hydroxypropionate:NADP+ oxidoreductase
obsolete UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis (GO:0035528)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin.
Synonyms: UDP-GlcNAc biosynthesis involved in chitin biosynthesis; UDP-GlcNAc biosynthetic process involved in chitin biosynthesis; UDP-GlcNAc biosynthetic process involved in chitin biosynthetic process; UDP-N-acetylglucosamine anabolism involved in chitin biosynthesis; UDP-N-acetylglucosamine biosynthetic process involved in chitin biosynthetic process; UDP-N-acetylglucosamine formation involved in chitin biosynthesis; UDP-N-acetylglucosamine synthesis involved in chitin biosynthesis
Comment: This term was obsoleted because it does not represent a specific pathway.
NADH pyrophosphatase activity (GO:0035529)
Namespace: molecular_function
Definition: Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.
Synonyms: NADH diphosphatase activity; NADH pyrophosphohydrolase activity
chemokine (C-C motif) ligand 6 production (GO:0035530)
Namespace: biological_process
Definition: The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CCL6 production
negative regulation of chemokine (C-C motif) ligand 6 production (GO:0035532)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).
Synonyms: negative regulation of CCL6 production; negative regulation of chemokine (C-C motif) ligand 6 secretion
positive regulation of chemokine (C-C motif) ligand 6 production (GO:0035533)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).
Synonyms: positive regulation of CCL6 production; positive regulation of chemokine (C-C motif) ligand 6 secretion
carbohydrate response element binding (GO:0035538)
Namespace: molecular_function
Definition: Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes.
Synonyms: ChoRE binding
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity (GO:0035539)
Namespace: molecular_function
Definition: Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
Synonyms: 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity; 8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity; 8-oxo-dGTP pyrophosphohydrolase activity; 8-oxo-dGTPase activity
regulation of SNARE complex assembly (GO:0035542)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
positive regulation of SNARE complex assembly (GO:0035543)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
negative regulation of SNARE complex assembly (GO:0035544)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
determination of left/right asymmetry in nervous system (GO:0035545)
Namespace: biological_process
Definition: The establishment of the nervous system with respect to the left and right halves.
urease complex (GO:0035550)
Namespace: cellular_component
Definition: A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).
Comment: Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes.
obsolete protein initiator methionine removal involved in protein maturation (GO:0035551)
Namespace: biological_process
Definition: OBSOLETE. Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein.
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete oxidative single-stranded DNA demethylation (GO:0035552)
Namespace: biological_process
Definition: OBSOLETE. Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
Synonyms: oxidative ssDNA demethylation
Comment: This term was obsoleted because it represents a molecular function.
termination of Roundabout signal transduction (GO:0035554)
Namespace: biological_process
Definition: The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated.
obsolete initiation of Roundabout signal transduction (GO:0035555)
Namespace: biological_process
Definition: OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO).
Synonyms: initiation of Roundabout signal transduction
Comment: This term was made obsolete because the meaning of the term is ambiguous.
intracellular signal transduction (GO:0035556)
Namespace: biological_process
Definition: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms: intracellular signal transduction pathway; intracellular signaling cascade; intracellular signaling pathway; signal transmission via intracellular cascade
obsolete phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling (GO:0035558)
Namespace: biological_process
Definition: OBSOLETE. The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms: phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling; phosphatidylinositol 3-kinase cascade involved in insulin receptor signalling; phosphoinositide 3-kinase cascade involved in insulin receptor signaling; phosphoinositide 3-kinase cascade involved in insulin receptor signalling; PI3K cascade involved in signaling from the insulin receptor
Comment: This term was made obsolete because the syntax of the term is incorrect.
obsolete MAPKKK cascade involved in epidermal growth factor receptor signaling (GO:0035559)
Namespace: biological_process
Definition: OBSOLETE. The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms: MAPKKK cascade involved in epidermal growth factor receptor signaling; MAPKKK cascade involved in epidermal growth factor receptor signalling; MAPKKK cascade involved in signaling from the EGFR
Comment: This term was made obsolete because the syntax of the term is incorrect.
pheophorbidase activity (GO:0035560)
Namespace: molecular_function
Definition: Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a.
Synonyms: phedase activity; pheophoridase activity; PPD activity
obsolete regulation of chromatin binding (GO:0035561)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
Comment: This term was obsoleted because it represents a molecular function.
negative regulation of chromatin binding (GO:0035562)
Namespace: biological_process
Definition: Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
positive regulation of chromatin binding (GO:0035563)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
regulation of kidney size (GO:0035564)
Namespace: biological_process
Definition: Any process that modulates the size of a kidney.
regulation of pronephros size (GO:0035565)
Namespace: biological_process
Definition: Any process that modulates the size of a pronephric kidney.
Synonyms: regulation of pronephric kidney size
regulation of metanephros size (GO:0035566)
Namespace: biological_process
Definition: Any process that modulates the size of a metanephric kidney.
Synonyms: regulation of metanephric kidney size
non-canonical Wnt signaling pathway (GO:0035567)
Namespace: biological_process
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin.
Synonyms: beta-catenin-independent Wnt receptor signaling pathway; non-canonical Wnt receptor signaling pathway; non-canonical Wnt receptor signalling pathway; non-canonical Wnt-activated signaling pathway
Comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term.
N-terminal peptidyl-proline methylation (GO:0035568)
Namespace: biological_process
Definition: The methylation of the N-terminal proline of proteins.
obsolete N-terminal peptidyl-proline trimethylation (GO:0035569)
Namespace: biological_process
Definition: OBSOLETE. The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline.
Synonyms: N-terminal peptidyl-proline trimethylation
Comment: This term was made obsolete because N-terminal proline residues cannot be trimethylated.
N-terminal peptidyl-serine methylation (GO:0035570)
Namespace: biological_process
Definition: The methylation of the N-terminal serine of proteins.