LiteFold/GO huggingface dataset:
proton-transporting two-sector ATPase complex (GO:0016469)
Namespace: cellular_component
Definition: A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
Synonyms: hydrogen-transporting two-sector ATPase complex; vacuolar hydrogen-transporting ATPase
vacuolar proton-transporting V-type ATPase complex (GO:0016471)
Namespace: cellular_component
Definition: A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
Synonyms: vacuolar hydrogen-translocating V-type ATPase complex
Comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'.
sodium ion-transporting F-type ATPase complex (GO:0016473)
Namespace: cellular_component
Definition: A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism.
Synonyms: sodium-translocating F-type ATPase complex
detection of nuclear:cytoplasmic ratio (GO:0016475)
Namespace: biological_process
Definition: The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell.
Synonyms: interpretation of nuclear:cytoplasmic ratio; sensing of nuclear:cytoplasmic ratio
regulation of embryonic cell shape (GO:0016476)
Namespace: biological_process
Definition: Any process that modulates the surface configuration of an embryonic cell.
Synonyms: shape changes of embryonic cells
negative regulation of transcription by RNA polymerase I (GO:0016479)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I.
Synonyms: down regulation of transcription from RNA polymerase I promoter; down-regulation of transcription from RNA polymerase I promoter; downregulation of transcription from RNA polymerase I promoter; inhibition of transcription from RNA polymerase I promoter; negative regulation of transcription from Pol I promoter; negative regulation of transcription from RNA polymerase I promoter
negative regulation of transcription by RNA polymerase III (GO:0016480)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.
Synonyms: down regulation of transcription from RNA polymerase III promoter; down-regulation of transcription from RNA polymerase III promoter; downregulation of transcription from RNA polymerase III promoter; inhibition of transcription from RNA polymerase III promoter; negative regulation of transcription from Pol III promoter; negative regulation of transcription from RNA polymerase III promoter
cytosolic transport (GO:0016482)
Namespace: biological_process
Definition: The directed movement of substances or organelles within the cytosol.
tryptophan hydroxylase activator activity (GO:0016483)
Namespace: molecular_function
Definition: Increases the activity of the enzyme tryptophase hydroxylase.
obsolete proprotein convertase 2 activator activity (GO:0016484)
Namespace: molecular_function
Definition: OBSOLETE. Required for the maturation and activation of proprotein convertase 2.
Synonyms: proprotein convertase 2 activator activity
Comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
protein processing (GO:0016485)
Namespace: biological_process
Definition: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
Synonyms: peptidolysis during protein maturation; protein maturation by peptide bond cleavage; protein maturation by peptide bond hydrolysis; protein maturation by proteolysis
peptide hormone processing (GO:0016486)
Namespace: biological_process
Definition: The generation of a mature peptide hormone by posttranslational processing of a prohormone.
farnesol metabolic process (GO:0016487)
Namespace: biological_process
Definition: The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.
Synonyms: farnesol metabolism
farnesol catabolic process (GO:0016488)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.
Synonyms: farnesol breakdown; farnesol catabolism; farnesol degradation
structural constituent of peritrophic membrane (GO:0016490)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster.
Synonyms: structural constituent of peritrophic matrix
oxidoreductase activity (GO:0016491)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Synonyms: oxidoreductase activity, acting on other substrates; redox activity
G protein-coupled neurotensin receptor activity (GO:0016492)
Namespace: molecular_function
Definition: Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
Synonyms: G protein coupled neurotensin receptor activity; G-protein coupled neurotensin receptor activity; neurotensin receptor activity, G protein coupled; neurotensin receptor activity, G-protein coupled
C-C chemokine receptor activity (GO:0016493)
Namespace: molecular_function
Definition: Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
C-X3-C chemokine receptor activity (GO:0016495)
Namespace: molecular_function
Definition: Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
substance P receptor activity (GO:0016496)
Namespace: molecular_function
Definition: Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity.
substance K receptor activity (GO:0016497)
Namespace: molecular_function
Definition: Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity.
Synonyms: neurokinin A receptor activity; neuromedin L receptor activity
neuromedin K receptor activity (GO:0016498)
Namespace: molecular_function
Definition: Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity.
Synonyms: neurokinin B receptor activity
orexin receptor activity (GO:0016499)
Namespace: molecular_function
Definition: Combining with orexin to initiate a change in cell activity.
prostacyclin receptor activity (GO:0016501)
Namespace: molecular_function
Definition: Combining with prostacyclin (PGI(2)) to initiate a change in cell activity.
Synonyms: PGI receptor activity; PGI(2) receptor activity; prostaglandin I receptor activity
nucleotide receptor activity (GO:0016502)
Namespace: molecular_function
Definition: Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
pheromone receptor activity (GO:0016503)
Namespace: molecular_function
Definition: Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior.
peptidase activator activity (GO:0016504)
Namespace: molecular_function
Definition: Binds to and increases the activity of a peptidase.
Synonyms: protease activator activity
peptidase activator activity involved in apoptotic process (GO:0016505)
Namespace: molecular_function
Definition: Binds to and increases the activity of a peptidase that is involved in the apoptotic process.
Synonyms: apoptotic protease activator activity
mitochondrial fatty acid beta-oxidation multienzyme complex (GO:0016507)
Namespace: cellular_component
Definition: A multienzyme complex possessing three activities in two subunits (alpha and beta) that catalyzes three steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. The alpha subunit comprises the enoyl-CoA hydratase (ECH) and 3-hydroxyacyl-CoA dehydrogenase (HACD) activities, and the beta subunit contains the acetyl-CoA C-acyltransferase (KACT)/thiolase activity.
Synonyms: fatty acid beta-oxidation multienzyme complex; trifunctional enzyme
obsolete long-chain-enoyl-CoA hydratase activity (GO:0016508)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms.
Comment: This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812.
long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity (GO:0016509)
Namespace: molecular_function
Definition: Catalysis of the reaction: a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD+ = a long-chain 3-oxo-fatty acyl-CoA + H+ + NADH. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Synonyms: beta-hydroxyacyl-CoA dehydrogenase activity; LCHAD; long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity; long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity; long-chain-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
obsolete endothelin-converting enzyme 1 activity (GO:0016512)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor.
Synonyms: ECE-1 activity; endothelin-converting enzyme 1 activity
Comment: This term was made obsolete because it represents a gene product.
core-binding factor complex (GO:0016513)
Namespace: cellular_component
Definition: A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.
Synonyms: AML1 complex; CBF complex; PEPB2 complex
SWI/SNF complex (GO:0016514)
Namespace: cellular_component
Definition: A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.
Synonyms: SWI-SNF complex
interleukin-13 receptor activity (GO:0016515)
Namespace: molecular_function
Definition: Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-13 receptor activity; IL-13R
interleukin-4 receptor complex (GO:0016516)
Namespace: cellular_component
Definition: A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor.
Synonyms: IL-4 receptor complex
interleukin-12 receptor activity (GO:0016517)
Namespace: molecular_function
Definition: Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-12 receptor activity; IL-12R
obsolete interleukin-14 receptor activity (GO:0016518)
Namespace: molecular_function
Definition: OBSOLETE. Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-14 receptor activity; IL-14R
Comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
gastric inhibitory peptide receptor activity (GO:0016519)
Namespace: molecular_function
Definition: Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein.
Synonyms: GIP receptor activity; glucose-dependent insulinotropic polypeptide receptor activity
growth hormone-releasing hormone receptor activity (GO:0016520)
Namespace: molecular_function
Definition: Combining with growth hormone-releasing hormone to initiate a change in cell activity.
pituitary adenylate cyclase activating polypeptide activity (GO:0016521)
Namespace: molecular_function
Definition: The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.
Synonyms: pituitary adenylyl cyclase activating polypeptide activity
latrotoxin receptor activity (GO:0016524)
Namespace: molecular_function
Definition: Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: latrophilin
negative regulation of angiogenesis (GO:0016525)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
Synonyms: down regulation of angiogenesis; down-regulation of angiogenesis; downregulation of angiogenesis; inhibition of angiogenesis
obsolete brain-specific angiogenesis inhibitor activity (GO:0016527)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: brain-specific angiogenesis inhibitor activity
Comment: This term was made obsolete because it is based on anatomical information, and describes at least one gene product. It has also never been defined.
sarcoplasm (GO:0016528)
Namespace: cellular_component
Definition: The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
metallochaperone activity (GO:0016530)
Namespace: molecular_function
Definition: Binding to and delivering metal ions to a target protein.
copper chaperone activity (GO:0016531)
Namespace: molecular_function
Definition: Directly binding to and delivering copper ions to a target protein.
Synonyms: copper carrier activity
superoxide dismutase copper chaperone activity (GO:0016532)
Namespace: molecular_function
Definition: A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity.
Synonyms: superoxide dismutase copper carrier activity
Comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'.
protein kinase 5 complex (GO:0016533)
Namespace: cellular_component
Definition: A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent.
Synonyms: cyclin-dependent protein kinase 5 holoenzyme complex
obsolete cyclin-dependent protein kinase 5 activator regulator activity (GO:0016536)
Namespace: molecular_function
Definition: OBSOLETE. Modulation of the activity of cyclin-dependent protein kinase 5 activator.
Synonyms: cyclin-dependent protein kinase 5 activator regulator activity; cyclin-dependent protein kinase 5 activator, intrinsic regulator activity
Comment: This term was made obsolete because it refers to a specific gene product.
cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)
Namespace: molecular_function
Definition: Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
Synonyms: cyclin; cyclin-dependent protein kinase regulator activity; cyclin-dependent protein kinase, intrinsic regulator activity; G1/S-specific cyclin; G2/M-specific cyclin
intein-mediated protein splicing (GO:0016539)
Namespace: biological_process
Definition: The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.
Synonyms: intein
protein autoprocessing (GO:0016540)
Namespace: biological_process
Definition: Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
obsolete intein (GO:0016541)
Namespace: molecular_function
Definition: OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity.
Synonyms: intein
Comment: This term was made obsolete because it refers to a protein sequence feature.
male courtship behavior, orientation prior to leg tapping and wing vibration (GO:0016543)
Namespace: biological_process
Definition: The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster.
Synonyms: male courtship behavior, orientation; male courtship behaviour, orientation; male courtship behaviour, orientation prior to leg tapping and wing vibration
male courtship behavior, tapping to detect pheromone (GO:0016544)
Namespace: biological_process
Definition: The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster.
Synonyms: male courtship behavior, tapping; male courtship behaviour, tapping; male courtship behaviour, tapping to detect pheromone
male courtship behavior, veined wing vibration (GO:0016545)
Namespace: biological_process
Definition: The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster.
Synonyms: male courtship behavior, wing vibration; male courtship behaviour, veined wing vibration; male courtship behaviour, wing vibration
male courtship behavior, proboscis-mediated licking (GO:0016546)
Namespace: biological_process
Definition: The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster.
Synonyms: male courtship behavior, licking; male courtship behaviour, licking; male courtship behaviour, proboscis-mediated licking
obsolete insertion or deletion editing (GO:0016550)
Namespace: biological_process
Definition: OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription.
Synonyms: insertion or deletion editing; insertion/deletion editing
Comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
obsolete posttranscriptional insertion or deletion editing (GO:0016551)
Namespace: biological_process
Definition: OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription.
Synonyms: posttranscriptional insertion or deletion editing; posttranscriptional insertion/deletion editing
Comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
obsolete cotranscriptional insertion or deletion editing (GO:0016552)
Namespace: biological_process
Definition: OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription.
Synonyms: cotranscriptional insertion or deletion editing; cotranscriptional insertion/deletion editing
Comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
base conversion or substitution editing (GO:0016553)
Namespace: biological_process
Definition: Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).
Synonyms: base conversion/substitution editing
cytidine to uridine editing (GO:0016554)
Namespace: biological_process
Definition: The conversion of a cytosine residue to uridine in an RNA molecule by deamination.
uridine to cytidine editing (GO:0016555)
Namespace: biological_process
Definition: The conversion of a uridine residue to cytosine in an RNA molecule by amination.
mRNA modification (GO:0016556)
Namespace: biological_process
Definition: The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.
Synonyms: mRNA editing
Comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
peroxisome membrane biogenesis (GO:0016557)
Namespace: biological_process
Definition: The process in which a peroxisome membrane is synthesized, aggregates, and bonds together.
peroxisome fission (GO:0016559)
Namespace: biological_process
Definition: The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.
Synonyms: peroxisome division; peroxisome proliferation