LiteFold/GO huggingface dataset:
type III transforming growth factor beta receptor binding (GO:0034714)
Namespace: molecular_function
Definition: Binding to a type III transforming growth factor beta receptor.
Synonyms: betaglycan binding; TGF-beta type III binding; transforming growth factor beta ligand binding to type III receptor; transforming growth factor beta receptor type III binding; type IIII TGF-beta binding
pICln-Sm protein complex (GO:0034715)
Namespace: cellular_component
Definition: A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
Synonyms: 6S pICln complex
Gemin3-Gemin4-Gemin5 complex (GO:0034716)
Namespace: cellular_component
Definition: A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly.
SMN-Gemin2 complex (GO:0034718)
Namespace: cellular_component
Definition: A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex.
SMN-Sm protein complex (GO:0034719)
Namespace: cellular_component
Definition: A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.
Synonyms: SMN-containing protein complex
Comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797.
obsolete histone H3-K4 demethylation (GO:0034720)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
Synonyms: H3K4 demethylation (me1 me2 and me3)
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-K4 demethylation, trimethyl-H3-K4-specific (GO:0034721)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone.
Synonyms: H3K4 demethylation (me3); histone H3-K4 tridemethylation
Comment: This term was obsoleted because it represents a molecular function.
gamma-glutamyl-peptidase activity (GO:0034722)
Namespace: molecular_function
Definition: Catalysis of the cleavage of a gamma-linked glutamate bond.
Synonyms: gamma-glutamyl hydrolase activity
obsolete DNA replication-dependent nucleosome disassembly (GO:0034725)
Namespace: biological_process
Definition: OBSOLETE. The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation.
Synonyms: DNA replication-dependent chromatin disassembly
Comment: This term was obsoleted because it did not describe a different process from that described by its parent.
obsolete DNA replication-independent nucleosome disassembly (GO:0034726)
Namespace: biological_process
Definition: OBSOLETE. The controlled disassembly of chromatin outside the context of DNA replication.
Synonyms: DNA replication-independent chromatin disassembly
Comment: This term was obsoleted because it did not describe a different process from that described by its parent.
piecemeal microautophagy of the nucleus (GO:0034727)
Namespace: biological_process
Definition: Degradation of a cell nucleus by microautophagy.
Synonyms: micronucleophagy; PMN
SmD-containing SMN-Sm protein complex (GO:0034730)
Namespace: cellular_component
Definition: An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex.
Synonyms: SMN-containing protein complex
Lsm-containing SMN-Sm protein complex (GO:0034731)
Namespace: cellular_component
Definition: An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA.
Synonyms: SMN-containing protein complex
transcription factor TFIIIB-beta complex (GO:0034733)
Namespace: cellular_component
Definition: A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters.
Comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans.
transcription factor TFIIIC1 complex (GO:0034734)
Namespace: cellular_component
Definition: A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity.
transcription factor TFIIIC2 complex (GO:0034735)
Namespace: cellular_component
Definition: A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter.
cholesterol O-acyltransferase activity (GO:0034736)
Namespace: molecular_function
Definition: Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.
Synonyms: ACAT activity; acyl coenzyme A-cholesterol-O-acyltransferase activity; acyl-CoA:cholesterol acyltransferase activity; acyl-CoA:cholesterol O-acyltransferase activity; acylcoenzyme A:cholesterol O-acyltransferase activity; cholesterol acyltransferase activity; cholesterol ester synthetase activity; cholesteryl ester synthetase activity
ergosterol O-acyltransferase activity (GO:0034737)
Namespace: molecular_function
Definition: Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester.
lanosterol O-acyltransferase activity (GO:0034738)
Namespace: molecular_function
Definition: Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester.
histone H4K16 deacetylase activity, hydrolytic mechanism (GO:0034739)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
Synonyms: histone deacetylase activity (H4-K16 specific); histone H4-K16 deacetylase activity; histone H4K12 deacetylase activity
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
TFIIIC-TOP1-SUB1 complex (GO:0034740)
Namespace: cellular_component
Definition: A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III.
Synonyms: TFIIIC-Topoisomerase 1-PC4 complex
APC-tubulin-IQGAP1 complex (GO:0034741)
Namespace: cellular_component
Definition: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization.
Synonyms: 60S APC complex
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
APC-IQGAP complex (GO:0034743)
Namespace: cellular_component
Definition: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
APC-IQGAP1-Cdc42 complex (GO:0034744)
Namespace: cellular_component
Definition: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
APC-IQGAP1-Rac1 complex (GO:0034745)
Namespace: cellular_component
Definition: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration.
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
APC-IQGAP1-CLIP-170 complex (GO:0034746)
Namespace: cellular_component
Definition: A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration.
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Par3-APC-KIF3A complex (GO:0034748)
Namespace: cellular_component
Definition: A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity.
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Scrib-APC-beta-catenin complex (GO:0034750)
Namespace: cellular_component
Definition: A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.
Synonyms: hScrib-APC-beta-catenin complex
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
aryl hydrocarbon receptor complex (GO:0034751)
Namespace: cellular_component
Definition: A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.
Synonyms: AhR complex; AHRC
nuclear aryl hydrocarbon receptor complex (GO:0034753)
Namespace: cellular_component
Definition: An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT).
Synonyms: 6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex; nuclear AhR complex; nuclear AHRC
iron ion transmembrane transport (GO:0034755)
Namespace: biological_process
Definition: A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
Synonyms: ferrous ion transmembrane transport; ferrous iron transmembrane transport; high affinity ferrous ion transmembrane transport; high affinity iron ion transport; high-affinity ferrous ion transmembrane transport; high-affinity iron ion transmembrane transport; high-affinity iron ion transport; iron ion membrane transport; iron(2+) transmembrane transport; low affinity iron ion transport; low-affinity iron ion transmembrane transport; low-affinity iron ion transport; transmembrane iron transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
regulation of iron ion transport (GO:0034756)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: regulation of Fe transport; regulation of iron import; regulation of iron ion import; regulation of iron transport
negative regulation of iron ion transport (GO:0034757)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of iron ion transport; down-regulation of iron ion transport; downregulation of iron ion transport; inhibition of iron ion transport; negative regulation of iron transport
positive regulation of iron ion transport (GO:0034758)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of iron ion transport; positive regulation of iron transport; stimulation of iron ion transport; up regulation of iron ion transport; up-regulation of iron ion transport; upregulation of iron ion transport
regulation of iron ion transmembrane transport (GO:0034759)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore.
Synonyms: regulation of iron ion membrane transport; regulation of transmembrane Fe transport; regulation of transmembrane iron ion transport; regulation of transmembrane iron transport
positive regulation of iron ion transmembrane transport (GO:0034761)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore.
Synonyms: activation of transmembrane iron ion transport; positive regulation of iron ion membrane transport; positive regulation of transmembrane iron ion transport; positive regulation of transmembrane iron transport; stimulation of transmembrane iron ion transport; up regulation of transmembrane iron ion transport; up-regulation of transmembrane iron ion transport; upregulation of transmembrane iron ion transport
regulation of transmembrane transport (GO:0034762)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
Synonyms: regulation of membrane transport
negative regulation of transmembrane transport (GO:0034763)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
Synonyms: down regulation of transmembrane transport; down-regulation of transmembrane transport; downregulation of transmembrane transport; inhibition of transmembrane transport; negative regulation of membrane transport
positive regulation of transmembrane transport (GO:0034764)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
Synonyms: activation of transmembrane transport; positive regulation of membrane transport; stimulation of transmembrane transport; up regulation of transmembrane transport; up-regulation of transmembrane transport; upregulation of transmembrane transport
regulation of monoatomic ion transmembrane transport (GO:0034765)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
Synonyms: regulation of ion membrane transport; regulation of ion transmembrane transport; regulation of transmembrane ion transport
negative regulation of monoatomic ion transmembrane transport (GO:0034766)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
Synonyms: down regulation of transmembrane ion transport; down-regulation of transmembrane ion transport; downregulation of transmembrane ion transport; inhibition of transmembrane ion transport; negative regulation of ion membrane transport; negative regulation of ion transmembrane transport; negative regulation of transmembrane ion transport
positive regulation of monoatomic ion transmembrane transport (GO:0034767)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
Synonyms: activation of transmembrane ion transport; positive regulation of ion membrane transport; positive regulation of ion transmembrane transport; positive regulation of transmembrane ion transport; stimulation of transmembrane ion transport; up regulation of transmembrane ion transport; up-regulation of transmembrane ion transport; upregulation of transmembrane ion transport
(E)-beta-ocimene synthase activity (GO:0034768)
Namespace: molecular_function
Definition: Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate.
basement membrane disassembly (GO:0034769)
Namespace: biological_process
Definition: The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.
Synonyms: basal lamina disassembly
Comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer.
obsolete histone H4-K20 methylation (GO:0034770)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone.
Synonyms: histone H4 K20 methylation; histone H4K20me; histone lysine H4 K20 methylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H4-K20 monomethylation (GO:0034771)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone.
Synonyms: histone H4 K20 monomethylation; histone lysine H4 K20 monomethylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H4-K20 dimethylation (GO:0034772)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone.
Synonyms: histone H4 K20 dimethylation; histone lysine H4 K20 dimethylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H4-K20 trimethylation (GO:0034773)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone.
Synonyms: histone H4 K20 trimethylation; histone lysine H4 K20 trimethylation
Comment: This term was obsoleted because it represents a molecular function.
secretory granule lumen (GO:0034774)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of a secretory granule.
glutathione transmembrane transport (GO:0034775)
Namespace: biological_process
Definition: A process in which glutathione is transported across a membrane.
Synonyms: glutathione membrane transport; transmembrane glutathione transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
response to histamine (GO:0034776)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
Synonyms: response to histamine stimulus
recycling endosome lumen (GO:0034777)
Namespace: cellular_component
Definition: The volume enclosed by the membranes of a recycling endosome.
obsolete 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity (GO:0034778)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
obsolete 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity (GO:0034779)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
obsolete N-cyclohexylformamide amidohydrolase activity (GO:0034781)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
obsolete pivalate-CoA ligase activity (GO:0034783)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
pivalyl-CoA mutase activity (GO:0034784)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA.
Comment: Pivalyl-CoA is a synonym for 2,2-dimethylpropanoyl-CoA.
salicylate 5-hydroxylase (NADH) activity (GO:0034785)
Namespace: molecular_function
Definition: Catalysis of the reaction: salicylate + NADH + O2 + H+ = 2,5-dihydroxybenzoate + NAD+ + H2O.
obsolete 9-fluorenone-3,4-dioxygenase activity (GO:0034786)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
obsolete 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity (GO:0034787)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
obsolete 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity (GO:0034788)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
obsolete 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity (GO:0034789)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.
obsolete 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity (GO:0034790)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-.
Comment: This term was obsoleted because there is no evidence that this specific reaction exists.