LiteFold/GO huggingface dataset:
myofibril assembly (GO:0030239)
Namespace: biological_process
Definition: Formation of myofibrils, the repeating units of striated muscle.
skeletal muscle thin filament assembly (GO:0030240)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.
skeletal muscle myosin thick filament assembly (GO:0030241)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.
autophagy of peroxisome (GO:0030242)
Namespace: biological_process
Definition: The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions.
Synonyms: peroxisome degradation; peroxisome disassembly; pexophagy
cellulose metabolic process (GO:0030243)
Namespace: biological_process
Definition: The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
Synonyms: cellulose metabolism
cellulose biosynthetic process (GO:0030244)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
Synonyms: cellulose anabolism; cellulose biosynthesis; cellulose formation; cellulose synthesis
cellulose catabolic process (GO:0030245)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
Synonyms: cellulose breakdown; cellulose catabolism; cellulose degradation
carbohydrate binding (GO:0030246)
Namespace: molecular_function
Definition: Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
Synonyms: selectin; sugar binding
polysaccharide binding (GO:0030247)
Namespace: molecular_function
Definition: Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
Synonyms: polysaccharide assembly with MHC class II protein complex
cellulose binding (GO:0030248)
Namespace: molecular_function
Definition: Binding to cellulose.
guanylate cyclase activator activity (GO:0030250)
Namespace: molecular_function
Definition: Binds to and increases the activity of guanylate cyclase.
Synonyms: guanylin
guanylate cyclase inhibitor activity (GO:0030251)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of guanylate cyclase.
growth hormone secretion (GO:0030252)
Namespace: biological_process
Definition: The regulated release of growth hormone from secretory granules into the blood.
Synonyms: somatotropin secretion
protein secretion by the type I secretion system (GO:0030253)
Namespace: biological_process
Definition: The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
Synonyms: protein secretion by the TOSS; protein secretion by the type I protein secretion system; type I protein secretion system
Comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'.
protein secretion by the type III secretion system (GO:0030254)
Namespace: biological_process
Definition: The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
Synonyms: protein secretion by the T3S; protein secretion by the T3SS; protein secretion by the TTSS; protein secretion by the type III protein secretion system; type III protein secretion system
Comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted.
protein secretion by the type IV secretion system (GO:0030255)
Namespace: biological_process
Definition: The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system.
Synonyms: protein secretion by the T4SS; protein secretion by the type IV protein secretion system; type IV protein secretion system
Comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'.
type I protein secretion system complex (GO:0030256)
Namespace: cellular_component
Definition: A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space.
Synonyms: ABC translocator complex
type III protein secretion system complex (GO:0030257)
Namespace: cellular_component
Definition: A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.
Synonyms: T3SS complex; TTSS complex
lipid modification (GO:0030258)
Namespace: biological_process
Definition: The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.
obsolete lipid glycosylation (GO:0030259)
Namespace: biological_process
Definition: OBSOLETE. Covalent attachment of a glycosyl residue to a lipid molecule.
Comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
chromosome condensation (GO:0030261)
Namespace: biological_process
Definition: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
Synonyms: DNA condensation; eukaryotic chromosome condensation; nuclear chromosome condensation
apoptotic nuclear changes (GO:0030262)
Namespace: biological_process
Definition: Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
Synonyms: apoptotic nuclear change
apoptotic chromosome condensation (GO:0030263)
Namespace: biological_process
Definition: The compaction of chromatin during apoptosis.
Synonyms: pyknosis
nuclear fragmentation involved in apoptotic nuclear change (GO:0030264)
Namespace: biological_process
Definition: The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.
Synonyms: apoptotic nuclear fragmentation; nuclear fragmentation during apoptosis; nucleus fragmentation
phospholipase C-activating opsin-mediated signaling pathway (GO:0030265)
Namespace: biological_process
Definition: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and transmitting the signal through the Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). The second messengers, including cGMP, activate channels that result in transmission of the light signal  through the synapses. Typical examples are rhabdomeric photoreceptors in the eyes of protostomes.
Synonyms: phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway; phospholipase C-activating rhodopsin mediated signaling pathway; PLC-activating rhodopsin mediated signaling pathway; rhodopsin mediated G protein signaling, coupled to IP3 second messenger; rhodopsin mediated G protein signalling, coupled to IP3 second messenger; rhodopsin mediated G-protein signaling, coupled to IP3 second messenger; rhodopsin mediated G-protein signalling, coupled to IP3 second messenger
quinate 3-dehydrogenase (NAD+) activity (GO:0030266)
Namespace: molecular_function
Definition: Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+.
Synonyms: quinate:NAD 3-oxidoreductase activity; quinate:NAD 5-oxidoreductase activity; quinate:NAD(+) 3-oxidoreductase activity; quinate:NAD(+) 5-oxidoreductase activity; quinic dehydrogenase activity
glyoxylate reductase (NADPH) activity (GO:0030267)
Namespace: molecular_function
Definition: Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.
Synonyms: glycolate:NADP+ oxidoreductase activity; glyoxylate reductase (NADP+); NADPH-glyoxylate reductase activity
methylenetetrahydromethanopterin dehydrogenase activity (GO:0030268)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H+ = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420.
Synonyms: 5,10-methylenetetrahydromethanopterin dehydrogenase activity; 5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity; N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity
tetrahydromethanopterin S-methyltransferase activity (GO:0030269)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na+(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na+(out). 2-(methylthio)ethanesulfonate is also known as methyl-CoM.
Synonyms: 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity; N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity; N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity; tetrahydromethanopterin methyltransferase activity
formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity (GO:0030270)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran.
Synonyms: formylmethanofuran-tetrahydromethanopterin formyltransferase activity; formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity; formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity; formylmethanofuran:tetrahydromethanopterin formyltransferase activity; FTR; N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity
obsolete chymase activity (GO:0030271)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa.
Synonyms: chymase activity; mast cell protease I activity; mast cell serine proteinase; SK protease activity; skeletal muscle (SK) protease activity; skeletal muscle protease; skin chymotryptic proteinase
Comment: This term was made obsolete because it represents a gene product.
5-formyltetrahydrofolate cyclo-ligase activity (GO:0030272)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate.
Synonyms: 5,10-methenyltetrahydrofolate synthetase activity; 5-formyltetrahydrofolate cyclo-ligase (ADP-forming); 5-formyltetrahydrofolate cyclodehydrase; 5-Formyltetrahydrofolate cyclodehydrase activity; formyltetrahydrofolic cyclodehydrase activity; methenyl-THF synthetase activity
LIM domain binding (GO:0030274)
Namespace: molecular_function
Definition: Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
LRR domain binding (GO:0030275)
Namespace: molecular_function
Definition: Binding to a LRR domain (leucine rich repeats) of a protein.
clathrin binding (GO:0030276)
Namespace: molecular_function
Definition: Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
maintenance of gastrointestinal epithelium (GO:0030277)
Namespace: biological_process
Definition: Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.
regulation of ossification (GO:0030278)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms: regulation of bone biosynthesis; regulation of bone formation
structural constituent of skin epidermis (GO:0030280)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure.
Synonyms: structural constituent of epidermis
structural constituent of cutaneous appendage (GO:0030281)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers.
bone mineralization (GO:0030282)
Namespace: biological_process
Definition: The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
Synonyms: bone calcification
obsolete testosterone dehydrogenase [NAD(P)+] activity (GO:0030283)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.
Comment: This term was obsoleted because it is an unnecessary grouing class.
nuclear estrogen receptor activity (GO:0030284)
Namespace: molecular_function
Definition: A nuclear receptor activity regulated by estrogen binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.
Synonyms: estrogen receptor activity
obsolete integral component of synaptic vesicle membrane (GO:0030285)
Namespace: cellular_component
Definition: OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral to synaptic vesicle membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
dynein complex (GO:0030286)
Namespace: cellular_component
Definition: Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
cell wall-bounded periplasmic space (GO:0030287)
Namespace: cellular_component
Definition: The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria.
Synonyms: cell wall bounded periplasmic space; cell wall-enclosed periplasmic space; inner wall zone; IWZ
outer membrane-bounded periplasmic space (GO:0030288)
Namespace: cellular_component
Definition: The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
Synonyms: outer membrane bounded periplasmic space; outer membrane-enclosed periplasmic space
protein phosphatase 4 complex (GO:0030289)
Namespace: cellular_component
Definition: A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.
sphingolipid activator protein activity (GO:0030290)
Namespace: molecular_function
Definition: Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.
Synonyms: saposin
protein serine/threonine kinase inhibitor activity (GO:0030291)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.
protein tyrosine kinase inhibitor activity (GO:0030292)
Namespace: molecular_function
Definition: Stops, prevents or reduces the activity of a protein tyrosine kinase.
transmembrane receptor protein tyrosine kinase inhibitor activity (GO:0030293)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase.
receptor signaling protein tyrosine kinase inhibitor activity (GO:0030294)
Namespace: molecular_function
Definition: Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.
Synonyms: receptor signalling protein tyrosine kinase inhibitor activity
protein kinase activator activity (GO:0030295)
Namespace: molecular_function
Definition: Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein tyrosine kinase activator activity (GO:0030296)
Namespace: molecular_function
Definition: Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
transmembrane receptor protein tyrosine kinase activator activity (GO:0030297)
Namespace: molecular_function
Definition: Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
receptor signaling protein tyrosine kinase activator activity (GO:0030298)
Namespace: molecular_function
Definition: Binds to and increases the activity of a receptor signaling protein tyrosine kinase.
Synonyms: receptor signalling protein tyrosine kinase activator activity
intestinal cholesterol absorption (GO:0030299)
Namespace: biological_process
Definition: Uptake of cholesterol into the blood by absorption from the small intestine.
regulation of intestinal cholesterol absorption (GO:0030300)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.
cholesterol transport (GO:0030301)
Namespace: biological_process
Definition: The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
deoxynucleotide transport (GO:0030302)
Namespace: biological_process
Definition: The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell.
obsolete stromelysin 2 activity (GO:0030303)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak.
Synonyms: matrix metalloproteinase 10 activity; MMP-10; proteoglycanase 2; stromelysin 2 activity; transin 2 activity
Comment: This term was made obsolete because it represents a gene product.
obsolete trypsin inhibitor activity (GO:0030304)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin.
Synonyms: trypsin inhibitor activity
Comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
heparanase activity (GO:0030305)
Namespace: molecular_function
Definition: Catalysis of the endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.
poly-N-acetyllactosamine metabolic process (GO:0030309)
Namespace: biological_process
Definition: The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.
Synonyms: poly-N-acetyllactosamine metabolism
poly-N-acetyllactosamine catabolic process (GO:0030310)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.
Synonyms: poly-N-acetyllactosamine breakdown; poly-N-acetyllactosamine catabolism; poly-N-acetyllactosamine degradation
poly-N-acetyllactosamine biosynthetic process (GO:0030311)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.
Synonyms: poly-N-acetyllactosamine anabolism; poly-N-acetyllactosamine biosynthesis; poly-N-acetyllactosamine formation; poly-N-acetyllactosamine synthesis
external encapsulating structure (GO:0030312)
Namespace: cellular_component
Definition: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
Comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.
cell envelope (GO:0030313)
Namespace: cellular_component
Definition: An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
junctional membrane complex (GO:0030314)
Namespace: cellular_component
Definition: Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).
Synonyms: triad junction
T-tubule (GO:0030315)
Namespace: cellular_component
Definition: Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
Synonyms: transverse tubule; triad
osteoclast differentiation (GO:0030316)
Namespace: biological_process
Definition: The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
Synonyms: osteoclast cell differentiation
flagellated sperm motility (GO:0030317)
Namespace: biological_process
Definition: The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
Synonyms: flagellated sperm movement; sperm flagellum movement; sperm flagellum movement involved in flagellated sperm motility; sperm flagellum movement involved in flagellated sperm movement; sperm motility; sperm movement
melanocyte differentiation (GO:0030318)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
Synonyms: melanocyte cell differentiation; melanophore differentiation