LiteFold/GO huggingface dataset:
obsolete fibroblast growth factor receptor signaling pathway involved in heart induction (GO:0003135)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction.
Synonyms: fibroblast growth factor receptor signalling pathway involved in heart induction
Comment: This term has been obsoleted because it represents a GO-CAM model.
obsolete negative regulation of heart induction by canonical Wnt signaling pathway (GO:0003136)
Namespace: biological_process
Definition: OBSOLETE. Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction.
Synonyms: negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway; negative regulation of heart induction by canonical Wnt receptor signaling pathway; negative regulation of heart induction by canonical Wnt receptor signalling pathway; negative regulation of heart induction by canonical Wnt-activated signaling pathway
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete Notch signaling pathway involved in heart induction (GO:0003137)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.
Synonyms: Notch signalling pathway involved in heart induction
Comment: This term was obsoleted because it represents a GO-CAM model.
primary heart field specification (GO:0003138)
Namespace: biological_process
Definition: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
Synonyms: FHS specification; first heart field specification
secondary heart field specification (GO:0003139)
Namespace: biological_process
Definition: The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
Synonyms: anterior heart field specification; second heart field specification; SHF specification
determination of left/right asymmetry in lateral mesoderm (GO:0003140)
Namespace: biological_process
Definition: The establishment of the lateral mesoderm with respect to the left and right halves.
obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry (GO:0003141)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination.
Synonyms: TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry; TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry; TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry; TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry; transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry; transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination; transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry
Comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm.
cardiogenic plate morphogenesis (GO:0003142)
Namespace: biological_process
Definition: The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.
Synonyms: cardiac crescent morphogenesis
embryonic heart tube morphogenesis (GO:0003143)
Namespace: biological_process
Definition: The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
embryonic heart tube formation (GO:0003144)
Namespace: biological_process
Definition: The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
outflow tract septum morphogenesis (GO:0003148)
Namespace: biological_process
Definition: The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
membranous septum morphogenesis (GO:0003149)
Namespace: biological_process
Definition: The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
muscular septum morphogenesis (GO:0003150)
Namespace: biological_process
Definition: The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
outflow tract morphogenesis (GO:0003151)
Namespace: biological_process
Definition: The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
obsolete morphogenesis of an epithelial fold involved in embryonic heart tube formation (GO:0003152)
Namespace: biological_process
Definition: OBSOLETE. The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
closure of embryonic heart tube (GO:0003153)
Namespace: biological_process
Definition: Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold.
obsolete BMP signaling pathway involved in determination of left/right symmetry (GO:0003154)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.
Synonyms: BMP signaling pathway involved in determination of left/right asymmetry; BMP signalling pathway involved in determination of left/right symmetry
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry (GO:0003155)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry.
Synonyms: BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination; BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry
Comment: This term was obsoleted because it represents a GO-CAM model.
regulation of animal organ formation (GO:0003156)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.
endocardium development (GO:0003157)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
endothelium development (GO:0003158)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
morphogenesis of an endothelium (GO:0003159)
Namespace: biological_process
Definition: The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.
endocardium morphogenesis (GO:0003160)
Namespace: biological_process
Definition: The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
cardiac conduction system development (GO:0003161)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
Synonyms: cardiac impulse conducting system development; heart conduction system development
atrioventricular node development (GO:0003162)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.
Synonyms: AV node development
sinoatrial node development (GO:0003163)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.
Synonyms: SA node development; SAN development; sinus node development
His-Purkinje system development (GO:0003164)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.
Purkinje myocyte development (GO:0003165)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.
Synonyms: cardiac Purkinje fiber development
bundle of His development (GO:0003166)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.
Synonyms: atrioventricular bundle development
atrioventricular bundle cell differentiation (GO:0003167)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.
Synonyms: AV bundle cell differentiation
Purkinje myocyte differentiation (GO:0003168)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.
Synonyms: cardiac Purkinje fiber cell differentiation
coronary vein morphogenesis (GO:0003169)
Namespace: biological_process
Definition: The process in which the anatomical structures of veins of the heart are generated and organized.
heart valve development (GO:0003170)
Namespace: biological_process
Definition: The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.
Synonyms: cardiac valve development
atrioventricular valve development (GO:0003171)
Namespace: biological_process
Definition: The progression of the atrioventricular valve over time, from its formation to the mature structure.
Synonyms: AV valve development
sinoatrial valve development (GO:0003172)
Namespace: biological_process
Definition: The progression of the sinoatrial valve over time, from its formation to the mature structure.
Synonyms: SA valve development
ventriculo bulbo valve development (GO:0003173)
Namespace: biological_process
Definition: The progression of the ventriculo bulbo valve over time, from its formation to the mature structure.
mitral valve development (GO:0003174)
Namespace: biological_process
Definition: The progression of the mitral valve over time, from its formation to the mature structure.
tricuspid valve development (GO:0003175)
Namespace: biological_process
Definition: The progression of the tricuspid valve over time, from its formation to the mature structure.
aortic valve development (GO:0003176)
Namespace: biological_process
Definition: The progression of the aortic valve over time, from its formation to the mature structure.
pulmonary valve development (GO:0003177)
Namespace: biological_process
Definition: The progression of the pulmonary valve over time, from its formation to the mature structure.
coronary sinus valve development (GO:0003178)
Namespace: biological_process
Definition: The progression of the valve of the coronary sinus over time, from its formation to the mature structure.
heart valve morphogenesis (GO:0003179)
Namespace: biological_process
Definition: The process in which the structure of a heart valve is generated and organized.
Synonyms: heart valve remodeling; heart valve remodelling
aortic valve morphogenesis (GO:0003180)
Namespace: biological_process
Definition: The process in which the structure of the aortic valve is generated and organized.
atrioventricular valve morphogenesis (GO:0003181)
Namespace: biological_process
Definition: The process in which the structure of the atrioventricular valve is generated and organized.
Synonyms: AV valve morphogenesis
coronary sinus valve morphogenesis (GO:0003182)
Namespace: biological_process
Definition: The process in which the structure of the coronary sinus valve is generated and organized.
mitral valve morphogenesis (GO:0003183)
Namespace: biological_process
Definition: The process in which the structure of the mitral valve is generated and organized.
pulmonary valve morphogenesis (GO:0003184)
Namespace: biological_process
Definition: The process in which the structure of the pulmonary valve is generated and organized.
sinoatrial valve morphogenesis (GO:0003185)
Namespace: biological_process
Definition: The process in which the structure of the sinoatrial valve is generated and organized.
Synonyms: SA valve morphogenesis
tricuspid valve morphogenesis (GO:0003186)
Namespace: biological_process
Definition: The process in which the structure of the tricuspid valve is generated and organized.
ventriculo bulbo valve morphogenesis (GO:0003187)
Namespace: biological_process
Definition: The process in which the structure of the ventriculo bulbo valve is generated and organized.
heart valve formation (GO:0003188)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
aortic valve formation (GO:0003189)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
atrioventricular valve formation (GO:0003190)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
Synonyms: AV valve formation
coronary sinus valve formation (GO:0003191)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
mitral valve formation (GO:0003192)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
pulmonary valve formation (GO:0003193)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
sinoatrial valve formation (GO:0003194)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
Synonyms: SA valve formation
tricuspid valve formation (GO:0003195)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
ventriculo bulbo valve formation (GO:0003196)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
endocardial cushion development (GO:0003197)
Namespace: biological_process
Definition: The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)
Namespace: biological_process
Definition: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.
endocardial cushion to mesenchymal transition involved in heart valve formation (GO:0003199)
Namespace: biological_process
Definition: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
Synonyms: endocardial cushion to mesenchymal transition involved in valve formation
obsolete endocardial cushion to mesenchymal transition involved in heart chamber septation (GO:0003200)
Namespace: biological_process
Definition: OBSOLETE. A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
epithelial to mesenchymal transition involved in coronary vasculature morphogenesis (GO:0003201)
Namespace: biological_process
Definition: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature.
obsolete endocardial cushion to mesenchymal transition involved in cardiac skeleton development (GO:0003202)
Namespace: biological_process
Definition: OBSOLETE. A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
endocardial cushion morphogenesis (GO:0003203)
Namespace: biological_process
Definition: The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
cardiac skeleton development (GO:0003204)
Namespace: biological_process
Definition: The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.
Synonyms: heart fibrous skeleton development
cardiac chamber morphogenesis (GO:0003206)
Namespace: biological_process
Definition: The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
Synonyms: heart chamber morphogenesis
cardiac chamber formation (GO:0003207)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
Synonyms: heart chamber formation