LiteFold/GO huggingface dataset:
Knl1/Spc105 complex (GO:0180019)
Namespace: cellular_component
Definition: A kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It is involved in kinetochore-microtubule binding, recruiting microtubule binding outer kinetochore subunits. It is essential for kinetochore binding by components of the spindle assembly checkpoint. In humans, budding and fission yeast, it consists of KNL1/ZWINT, Spc105p/Kre28p and Spc7/Sos1, members of the Panther PTHR28260 and PTHR37329 families, respectively.
Synonyms: KNL-1 complex; KNL1 complex; Spc105 complex; Spc105p/Kre28p complex
membrane bending activity (GO:0180020)
Namespace: molecular_function
Definition: The activity of bending or deforming a membrane. This activity can occur by multiple mechanisms including the insertion amphipathic domains into one or both leaflets.
Synonyms: membrane curving
U6 snRNA 2'-O-ribose methyltransferase activity (GO:0180021)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + U6 snRNA = S-adenosyl-L-homocysteine + U6 containing a 3'-terminal 2'-O-methylnucleotide + H+.
RQC-trigger complex (GO:0180022)
Namespace: cellular_component
Definition: A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B.
Synonyms: activating signal cointegrator 1 complex; ASC-1 complex; RQT complex
cytosolic large ribosomal subunit assembly (GO:0180023)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a cytosolic large ribosomal subunit.
membrane grommet activity (GO:0180024)
Namespace: molecular_function
Definition: An activity in which a protein, or group of proteins, acts to restrict the size of a fenestration in a membrane or membrane system (i.e. restrict the diameter of a hole in a membrane). An example of this is the molecular function is performed by ESCRT-III proteins at the nuclear envelope of fission yeast during anaphase B.
cytosolic small ribosomal subunit assembly (GO:0180025)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a cytosolic small ribosomal subunit.
mitochondrial small ribosomal subunit assembly (GO:0180026)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial small ribosomal subunit.
mitotic spindle pole body attachment site (GO:0180028)
Namespace: cellular_component
Definition: A region of the nuclear envelope to which a spindle pole body (SPB) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope.
phosphate ion export across plasma membrane (GO:0180029)
Namespace: biological_process
Definition: The directed movement of phosphate ions (Pi) from inside of a cell, across the plasma membrane and into the extracellular region.
inositol phosphate kinase activity (GO:0180030)
Namespace: molecular_function
Definition: Catalysis of the reaction: inositol phosphate + ATP = inositol phosphate + ADP.
snoRNA 2,2,7-trimethylguanosine (TMG) capping (GO:0180031)
Namespace: biological_process
Definition: The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5' end of an snoRNA. The snoRNA capping includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed snoRNAs are also TMG capped.
Synonyms: snoRNA 2,2,7-trimethylguanosine (TMG) cap formation; snoRNA capping
histone H4K5 deacetylase activity, hydrolytic mechanism (GO:0180032)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 5) + H2O = histone H4 L-lysine (position 5) + acetate. This reaction represents the removal of an acetyl group from lysine at position 5 of the histone H4 protein.
Synonyms: histone H4K5 deacetylase activity
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H4K8 deacetylase activity, hydrolytic mechanism (GO:0180033)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 8) + H2O = histone H4 L-lysine (position 8) + acetate. This reaction represents the removal of an acetyl group from lysine at position 8 of the histone H4 protein.
Synonyms: histone H4K48 deacetylase activity
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway (GO:0180034)
Namespace: biological_process
Definition: Any process involved in transcription termination-coupled 3' processing of RNA polymerase II lncRNA transcripts by the 3' end cleavage and addition of a poly(A) tail.
Synonyms: lncRNA 3' end processing; lncRNA 3'-end processing
lncRNA processing (GO:0180035)
Namespace: biological_process
Definition: Any process involved in the conversion of one or more primary lncRNA transcripts into one or more mature lncRNA molecules.
nuclear lncRNA surveillance (GO:0180036)
Namespace: biological_process
Definition: A process that identifies and degrades defective or aberrant lncRNAs within the nucleus.
rapid tRNA decay (GO:0180037)
Namespace: biological_process
Definition: A cytoplasmic tRNA surveillance pathway that targets mature hypomodified tRNAs, catalyzed by 5'-3' exonucleases Xrn1 (S. cerevisiae/human) and Rat1 (S. cerevisiae) XRN2 human, and regulated by adenosine 3',5' bisphosphate (pAp).
cyclin L-CDK11 complex (GO:0180038)
Namespace: cellular_component
Definition: A protein complex consisting of cyclin L and cyclin-dependent kinase 11 (CDK11). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
Synonyms: Cdk11-Cyclin L complex
regulation of pheromone response MAPK cascade (GO:0180039)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of a pheromone response MAPK cascade.
negative regulation of pheromone response MAPK cascade (GO:0180040)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of a pheromone response MAPK cascade.
dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity (GO:0180041)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H+.
Synonyms: glycolipid 1,4-alpha-mannosyltransferase activity; glycosylphosphatidylinositol-mannosyltransferase I activity; GPI-MT-I activity
polyphosphate import into vacuole (GO:0180042)
Namespace: biological_process
Definition: The directed movement of polyphosphate into the vacuole across the vacuolar membrane.
inositol pyrophosphate sensor activity (GO:0180043)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of an inositol pyrophosphate.
borate channel activity (GO:0180044)
Namespace: molecular_function
Definition: Enables the facilitated diffusion of borate (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
type 1 mitophagy (GO:0180045)
Namespace: biological_process
Definition: The selective autophagy process in which a functional mitochondrion is degraded by macroautophagy to provide metabolic precursors during nutrient deprivation or to remove mitochondria in excess of metabolic needs.
GPI anchored protein biosynthesis (GO:0180046)
Namespace: biological_process
Definition: Any process leading to the post-translational modification of a protein with a GPI anchor to achieve full functional capacity of the protein.
dolichol phosphate mannose biosynthetic process (GO:0180047)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of dolichol phosphate mannose.
Synonyms: Dol-P-Man biosynthesis; dolichol phosphate mannose biosynthesis; dolichol-P-mannose biosynthesis
phosphatidylinositol 4-phosphate biosynthetic process (GO:0180048)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of phosphatidylinositol 4-phosphate.
Synonyms: 1-phosphatidyl-1D-myo-inositol 4-phosphate biosynthesis; 1-phosphatidyl-1D-myo-inositol biosynthetic process; phosphatidylinositol (PI)-4- phosphate biosynthetic process; phosphatidylinositol-4-phosphate synthesis; PI4P biosynthesis
Mrh5C translation activator complex (GO:0180049)
Namespace: cellular_component
Definition: A protein complex capable of translation activator activity, and is involved in the activation of cox1 mRNA for translation. In fission yeast this complex consists of a scaffold (Sls1), a helicase (Mrh5), and PPR repeat proteins Prr4 and Mtf2.
Synonyms: Mrh5C complex
protein-mitochondrial outer membrane tethering activity (GO:0180050)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a protein or protein complex and a mitochondrial outer membrane lipid or membrane-associated protein, in order to maintain the localization of the protein, or protein complex at a specific mitochondrial outer membrane location.
translation factor activity (GO:0180051)
Namespace: molecular_function
Definition: A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation.
mitochondrial translation initiation complex (GO:0180052)
Namespace: cellular_component
Definition: A ribonucleoprotein complex comprising the mRNA bound fully assembled 55S mitoribosome with the tRNA-met positioned in the P-site of the mitochondrial small subunit to recognize the mRNA start codon.
Synonyms: mitochondrial initiation complex; mtIC
mitochondrial translation preinitiation complex (GO:0180053)
Namespace: cellular_component
Definition: A ribonucleoprotein complex comprising of the 28S small mitoribosomal subunit (mt-SSU) and mitochondrial initiation factors (e.g. mtIF3 and mtIF2-GTP) and the initiator tRNA-Met and an mRNA binding. The early steps of translation initiation, including the association of the 28S mitochondrial small subunit (mt-SSU) with initiation factors (mtIF3 and mtIF2), prevention of premature large subunit (39S) joining occur during the assembly of the mitochondrial pre-initiation complex (mtPIC).
Synonyms: mitochondrial translation pre-initiation complex
ribosome translocase activity (GO:0180054)
Namespace: molecular_function
Definition: A motor activity that generates movement of a ribosome one codon forward along the mRNA, driven by GTP hydrolysis.
citrate:2-oxoglutarate antiporter activity (GO:0180056)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + 2-oxogluarate(in) = citrate(in) + 2-oxogluarat(out).
protein post-translational transfer of dolichol-linked oligosaccharide (GO:0180057)
Namespace: biological_process
Definition: A N-linked protein glycosylation process in which the preassembled dolichol-linked oligosaccharide precursor is transfered co-translationally to an asparagine residue within the motif Asn-X-Ser/Thr of the target protein. This is mediated by the OSTB complex.
Synonyms: protein N-linked glycosylation via asparagine, post-translational; protein N-linked glycosylation via asparagine, posttranslational; protein posttranslational transfer of dolichol-linked oligosaccharide
protein co-translational transfer of dolichol-linked oligosaccharide (GO:0180058)
Namespace: biological_process
Definition: A N-linked protein glycosylation process in which the preassembled dolichol-linked oligosaccharide precursor is transfered post-translationally to an asparagine residue within the motif Asn-X-Ser/Thr of the target protein. This is mediated by the OSTA complex.
Synonyms: protein cotranslational transfer of dolichol-linked oligosaccharide; protein N-linked glycosylation via asparagine, co-translational; protein N-linked glycosylation via asparagine, cotranslational
protein O-linked glycosylation via glucose (GO:0180059)
Namespace: biological_process
Definition: A glycoprotein biosynthetic process starting with the covalent linkage of a glucose via a beta-glycosidic bond to the oxygen atom of a serine, threonine or tyrosine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan.
Synonyms: protein O-linked glucosylation
siderophore-dependent iron import pathway (GO:0180060)
Namespace: biological_process
Definition: A process in which iron siderophores (low-molecular-weight, high-affinity iron-chelating compounds) are exported to scavenge iron and the iron-loaded siderophores imported back into the cell by transmembrane transport or endocytosis.
native siderophore export across plasma membrane (GO:0180061)
Namespace: biological_process
Definition: The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from inside of a cell, across the plasma membrane and into the extracellular region.
protein O-linked glycosylation via arabinose (GO:0180063)
Namespace: biological_process
Definition: A glycoprotein biosynthetic process starting with the covalent linkage of an arabinose via a beta-glycosidic bond to the oxygen atom of the hydroxyl group of a hydroxyproline in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan.
Synonyms: protein O-linked arabinosylation
protein O-linked glycosylation via xylose (GO:0180064)
Namespace: biological_process
Definition: A glycoprotein biosynthetic process starting with the covalent linkage of a xylose via a beta-glycosidic bond to the oxygen atom of a serine or a threonine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan.
Synonyms: protein O-linked xylosylation
mitochondrial RNA polymerase general transcription initiation factor activity (GO:0180066)
Namespace: molecular_function
Definition: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation by the mitochondrial RNA polymerase.
terreate biosynthetic process (GO:0180067)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of terreate, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities.
Synonyms: terreic acid biosynthetic process
negative regulation of carbohydrate utilization (GO:0180068)
Namespace: biological_process
Definition: Any process that  that stops, prevents, or reduces the frequency, rate or extent of carbohydrate utilization.
positive regulation of terreate biosynthetic process (GO:0180069)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of terreate.
regulation of anthocyanin catabolic process (GO:1900000)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of anthocyanin catabolic process.
Synonyms: regulation of anthocyanin breakdown; regulation of anthocyanin catabolism; regulation of anthocyanin degradation
negative regulation of anthocyanin catabolic process (GO:1900001)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process.
Synonyms: down regulation of anthocyanin breakdown; down regulation of anthocyanin catabolic process; down regulation of anthocyanin catabolism; down regulation of anthocyanin degradation; negative regulation of anthocyanin breakdown; negative regulation of anthocyanin catabolism; negative regulation of anthocyanin degradation
positive regulation of anthocyanin catabolic process (GO:1900002)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process.
Synonyms: positive regulation of anthocyanin breakdown; positive regulation of anthocyanin catabolism; positive regulation of anthocyanin degradation; up regulation of anthocyanin breakdown; up regulation of anthocyanin catabolic process; up regulation of anthocyanin catabolism; up regulation of anthocyanin degradation
regulation of serine-type endopeptidase activity (GO:1900003)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity.
Synonyms: regulation of blood coagulation factor activity
negative regulation of serine-type endopeptidase activity (GO:1900004)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
Synonyms: down regulation of blood coagulation factor activity; down regulation of serine-type endopeptidase activity; negative regulation of blood coagulation factor activity
positive regulation of serine-type endopeptidase activity (GO:1900005)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity.
Synonyms: positive regulation of blood coagulation factor activity; up regulation of blood coagulation factor activity; up regulation of serine-type endopeptidase activity
positive regulation of dendrite development (GO:1900006)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of dendrite development.
Synonyms: up regulation of dendrite development
obsolete regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging (GO:1900007)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging.
Synonyms: regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing; regulation of extrachromosomal rDNA circle accumulation during replicative cell aging; regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging
Comment: This term was obsoleted because it represents an assay, not a true biological process.
obsolete negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging (GO:1900008)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging.
Synonyms: down regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing; down regulation of extrachromosomal rDNA circle accumulation during replicative cell aging; down regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging; down regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging; negative regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing; negative regulation of extrachromosomal rDNA circle accumulation during replicative cell aging; negative regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging
Comment: This term was obsoleted because it represents an assay, not a true biological process.
obsolete positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging (GO:1900009)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging.
Synonyms: positive regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing; positive regulation of extrachromosomal rDNA circle accumulation during replicative cell aging; positive regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging; up regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing; up regulation of extrachromosomal rDNA circle accumulation during replicative cell aging; up regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging; up regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging
Comment: This term was obsoleted because it represents an assay, not a true biological process.
obsolete regulation of corticotropin-releasing hormone receptor activity (GO:1900010)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone receptor activity.
Synonyms: regulation of adrenocorticotropin-releasing hormone receptor activity; regulation of corticotropin-releasing factor receptor activity; regulation of CRF receptor activity; regulation of CRH receptor activity
Comment: This term was obsoleted because it represents a molecular function.
negative regulation of corticotropin-releasing hormone receptor activity (GO:1900011)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity.
Synonyms: down regulation of adrenocorticotropin-releasing hormone receptor activity; down regulation of corticotropin-releasing factor receptor activity; down regulation of corticotropin-releasing hormone receptor activity; down regulation of CRF receptor activity; down regulation of CRH receptor activity; negative regulation of adrenocorticotropin-releasing hormone receptor activity; negative regulation of corticotropin-releasing factor receptor activity; negative regulation of CRF receptor activity; negative regulation of CRH receptor activity
obsolete positive regulation of corticotropin-releasing hormone receptor activity (GO:1900012)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity.
Synonyms: positive regulation of adrenocorticotropin-releasing hormone receptor activity; positive regulation of corticotropin-releasing factor receptor activity; positive regulation of CRF receptor activity; positive regulation of CRH receptor activity; up regulation of adrenocorticotropin-releasing hormone receptor activity; up regulation of corticotropin-releasing factor receptor activity; up regulation of corticotropin-releasing hormone receptor activity; up regulation of CRF receptor activity; up regulation of CRH receptor activity
Comment: This term was obsoleted because it represents a molecular function.