LiteFold/GO huggingface dataset:
obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation (GO:0039558)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity.
Synonyms: promotion of IRF-7 SUMOylation; suppression by virus of host interferon regulatory factor-7 activity by positive regulation of IRF7 sumoylation
Comment: The reason for obsoleting is that the term is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process (GO:0039559)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome.
Synonyms: promotion by virus of proteosome-dependent IRF7 degradation
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity (GO:0039560)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. For example, viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes.
Synonyms: disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity; inhibition of host interferon regulatory factor-9 by virus; inhibition of host IRF9 by virus; suppression by virus of host interferon regulatory factor 9 activity; suppression by virus of host IRF9 activity; suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity
Comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
obsolete suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus (GO:0039561)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism.
Synonyms: suppression by virus of host IRF9 activity by nuclear localization of IRF9; suppression of interferon signaling by nuclear accumulation of IRF9
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity (GO:0039562)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
Synonyms: disruption by virus of host JAK-STAT cascade via inhibition of STAT activity; inhibition by virus of host STAT activity; suppression by virus of host JAK-STAT cascade via inhibition of STAT activity; suppression by virus of host signal transducer and activator of transcription activity; suppression by virus of host STAT activity
Comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity (GO:0039563)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1).
Synonyms: disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity; inhibition by virus of host STAT1 activity; inhibition of host STAT1 by virus; suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; suppression by virus of host STAT1 activity
Comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity (GO:0039564)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).
Synonyms: disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity; inhibition by virus of host STAT2 activity; inhibition of host STAT2 by virus; suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; suppression by virus of host STAT2 activity
Comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
obsolete suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus (GO:0039567)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes.
Synonyms: cytoplasmic sequestration of STAT1; suppression by virus of host STAT1 activity by cytoplasmic sequestering of STAT1
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process (GO:0039569)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome.
Synonyms: promotion by virus of proteosome-dependent STAT2 degradation; suppression by virus of host STAT2 activity by positive promotion of STAT2 proteasome-mediated degradation; targeting STAT2 for proteasome-mediated degradation
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus (GO:0039570)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes.
Synonyms: cytoplasmic sequestering of STAT2; cytoplasmic sequestration of STAT2
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation (GO:0039571)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation.
Synonyms: inhibition by virus of tyrosine phosphorylation of STAT1
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation (GO:0039572)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation.
Synonyms: inhibition by virus of tyrosine phosphorylation of STAT2
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host complement activation (GO:0039573)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase.
Synonyms: inhibition of host complement activation by virus; inhibition of host complement cascade by virus
Comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host complement activation ; GO:0042784.
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity (GO:0039574)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits.
Synonyms: disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity; suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity; suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity; suppression by virus of host TYK2 activity
Comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
obsolete suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation (GO:0039575)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2.
Synonyms: inhibition by virus of host TYK2 activation; inhibition by virus of host TYK2 phosphorylation
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity (GO:0039576)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host JAK1 (Janus Kinase 1).
Synonyms: disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity; inhibition of host JAK activity by virus; negative regulation by virus of host JAK; negative regulation by virus of tyrosine phosphorylation of host STAT protein; suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity; suppression by virus of host JAK1 activity; suppression by virus of tyrosine phosphorylation of host STAT protein; viral inhibition of tyrosine phosphorylation of host STAT protein
Comment: This term is for annotation of symbiont proteins that counteract the host innate immune response.
obsolete suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation (GO:0039577)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1.
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host JAK1 activity via JAK1 binding (GO:0039578)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive.
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
symbiont-mediated suppression of host ISG15-protein conjugation (GO:0039579)
Namespace: biological_process
Definition: Any process in which a symbiont inhibits or disrupts a host ubiquitin-like protein ISG15 conjugation to a substrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. For example, some viruses escape the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15, while the papain-like protease from the coronavirus cleaves ISG15 derivatives.
Synonyms: suppression by virus of host ISG15 activity; suppression by virus of host ISG15-protein conjugation
symbiont-mediated suppression of host PKR/eIFalpha signaling (GO:0039580)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts host PKR (Protein Kinase regulated by RNA) signaling. PKR phosphorylates host targets such as the translation initiation factor eIF2alpha that inhibits protein synthesis as an antimicrobial response. Inhibition of host PKR signaling maintains the host ability to translate mRNA. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: suppression by virus of host EIF2AK2 activity; suppression by virus of host PKR activity; suppression by virus of host PKR signaling
obsolete suppression by virus of host PKR activity via double-stranded RNA binding (GO:0039581)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by binding to double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding.
Synonyms: suppression by virus of host PKR activity by binding to dsRNA
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host PKR activity by positive regulation of PKR nuclear localization (GO:0039582)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha).
Synonyms: suppression by virus of host PKR activity by nuclear sequestration of PKR; suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus; suppression by virus of host PKR activity by sequestering of PKR in nucleus
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host PKR activity by positive regulation of PKR catabolic process (GO:0039583)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes.
Synonyms: downregulation of PKR by degradation through proteosome; promotion by virus of proteosome-dependent PKR degradation
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host protein kinase activity (GO:0039584)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity.
Comment: This term was obsoleted because it is a molecular function represented as a biological process.
PKR/eIFalpha signaling (GO:0039585)
Namespace: biological_process
Definition: An intracellular signaling cassette that starts with activation and autophosphorylation of PKR (also known as EIF2AK2), which phosphorylates proteins including the translation initiation factor eIF2 to inhibit translation. PKR is activated by stress signals and during the antiviral response, activated by binding to viral double-stranded RNA (dsRNA) leading to inhibition of protein synthesis during viral infection.
Synonyms: EIF2AK2 signal transduction; EIF2AK2/PRK signaling; PKR signal transduction; PKR signaling pathway; signaling through PKR
obsolete modulation by virus of host PP1 activity (GO:0039586)
Namespace: biological_process
Definition: OBSOLETE. The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response.
Synonyms: modulation of host PP1 activity by virus; regulation by virus of host PP1 activity
Comment: This term was obsoleted because it is a molecular function represented as a biological process.
symbiont-mediated-mediated suppression of host tetherin activity (GO:0039587)
Namespace: biological_process
Definition: Any process in which a symbiont stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.
Synonyms: evasion of suppression of viral release by host via inhibition of host tetherin activity; inhibition of host BST2/Tetherin by virus; suppression by virus of host tetherin activity
symbiont-mediated suppression of host antigen processing and presentation (GO:0039588)
Namespace: biological_process
Definition: A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC protein complex.
Synonyms: suppression by virus of host antigen processing and presentation
obsolete suppression by virus of host TAP complex (GO:0039589)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response.
Synonyms: inhibition of host TAP by virus
Comment: This term was obsoleted because this type of process is now represented by the actual function inhibited.
symbiont-mediated arrest of host cell cycle during G2/M transition (GO:0039592)
Namespace: biological_process
Definition: A process in which a symbiont interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase. The arrest in G2/M allows some viruses to replicate their genome before cells enter mitosis. Alternatively, it can inhibit the antiviral immune response by preventing the clonal expansion of infected lymphocytes.
Synonyms: host G2/M cell cycle arrest by virus; perturbation by virus of G2/M transition of host mitotic cell cycle; suppression by virus of G2/M transition of host mitotic cell cycle
symbiont-mediated perturbation of host exit from mitosis (GO:0039593)
Namespace: biological_process
Definition: A process in which a virus interferes with the host cell completing the M phase of the cell cycle.
Synonyms: inhibition of host mitotic exit by virus; perturbation by virus of host exit from mitosis; suppression by virus of host exit from mitosis
obsolete endoribonuclease activity involved in viral induction of host mRNA catabolic process (GO:0039594)
Namespace: molecular_function
Definition: OBSOLETE. Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA.
Comment: This term was obsoleted because it represents the same process as symbiont-mediated degradation of host mRNA ; GO:0039595.
symbiont-mediated degradation of host mRNA (GO:0039595)
Namespace: biological_process
Definition: The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA).
Synonyms: induction by virus of catabolism of host mRNA; induction by virus of host mRNA catabolic process; induction of host mRNA decay; promotion of host mRNA degradation; viral induction of host mRNA decay; virus-mediated mRNA decay
obsolete modulation by virus of host protein dephosphorylation (GO:0039596)
Namespace: biological_process
Definition: OBSOLETE. Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein.
Comment: This term was obsoleted because it is a molecular function represented as a biological process.
obsolete induction by virus of host endoribonuclease activity (GO:0039597)
Namespace: biological_process
Definition: OBSOLETE. Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity.
Synonyms: viral induction of host RNAse activity
Comment: This term was obsoleted because it represents a molecular function.