LiteFold/GO huggingface dataset:
obsolete cellular di-, tri-valent inorganic anion homeostasis (GO:0030319)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell.
Synonyms: cellular di-, tri-valent inorganic anion homeostasis
Comment: This term was made obsolete because it has been split.
obsolete cellular monovalent inorganic anion homeostasis (GO:0030320)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell.
Comment: This term was obsoleted because it is an unnecessary grouping class.
transepithelial chloride transport (GO:0030321)
Namespace: biological_process
Definition: The directed movement of chloride ions from one side of an epithelium to the other.
stabilization of membrane potential (GO:0030322)
Namespace: biological_process
Definition: The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
respiratory tube development (GO:0030323)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.
lung development (GO:0030324)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
adrenal gland development (GO:0030325)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
Synonyms: interrenal gland
prenylated protein catabolic process (GO:0030327)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of prenylated proteins.
Synonyms: prenylated protein breakdown; prenylated protein catabolism; prenylated protein degradation
prenylcysteine catabolic process (GO:0030328)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.
Synonyms: prenylcysteine breakdown; prenylcysteine catabolism; prenylcysteine degradation
obsolete prenylcysteine metabolic process (GO:0030329)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.
Synonyms: prenylcysteine metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
DNA damage response, signal transduction by p53 class mediator (GO:0030330)
Namespace: biological_process
Definition: A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms: DNA damage response, activation of p53; p53 signaling pathway; p53-mediated DNA damage response; TP53 signaling pathway
nuclear estrogen receptor binding (GO:0030331)
Namespace: molecular_function
Definition: Binding to a nuclear estrogen receptor.
Synonyms: estrogen receptor binding
cyclin binding (GO:0030332)
Namespace: molecular_function
Definition: Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
regulation of cell migration (GO:0030334)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of cell migration.
positive regulation of cell migration (GO:0030335)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cell migration.
Synonyms: activation of cell migration; stimulation of cell migration; up regulation of cell migration; up-regulation of cell migration; upregulation of cell migration
negative regulation of cell migration (GO:0030336)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
Synonyms: down regulation of cell migration; down-regulation of cell migration; downregulation of cell migration; inhibition of cell migration
DNA polymerase processivity factor activity (GO:0030337)
Namespace: molecular_function
Definition: An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.
Synonyms: processivity clamp; sliding clamp
CMP-N-acetylneuraminate monooxygenase activity (GO:0030338)
Namespace: molecular_function
Definition: Catalysis of the reaction: CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O.
Synonyms: CMP-N-acetylneuraminate hydroxylase activity; CMP-N-acetylneuraminic acid hydroxylase activity; CMP-Neu5Ac hydroxylase activity; cytidine monophosphoacetylneuraminate monooxygenase activity
Comment: Note that this was EC:1.14.13.45.
fatty-acyl-ethyl-ester synthase activity (GO:0030339)
Namespace: molecular_function
Definition: Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol.
Synonyms: FAEE synthase activity; FAEES activity; fatty-acyl ethyl ester synthase; long-chain-fatty-acyl-ethyl-ester acylhydrolase activity
hyaluronate lyase activity (GO:0030340)
Namespace: molecular_function
Definition: Catalysis of the reaction: hyaluronate(n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O.
Synonyms: glucuronoglycosaminoglycan lyase activity; hyaluronidase activity; mucinase activity; spreading factor activity
chondroitin AC lyase activity (GO:0030341)
Namespace: molecular_function
Definition: Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.
Synonyms: ChnAC; chondroitin AC eliminase activity; chondroitin lyase activity; chondroitin sulfate lyase activity; chondroitinase AC; chondroitinase activity
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity (GO:0030342)
Namespace: molecular_function
Definition: Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol).
Synonyms: 1,25-(OH)2D3 24-hydroxylase activity; calcitriol 24-hydroxylase activity
vitamin D3 25-hydroxylase activity (GO:0030343)
Namespace: molecular_function
Definition: Catalysis of the reaction: calciol (vitamin D3) + reduced [NADPH--hemoprotein reductase] + O2 = calcidiol + oxidized [NADPH--hemoprotein reductase] + H2O + H+.
Synonyms: cholecalciferol 25-hydroxylase activity
structural constituent of tooth enamel (GO:0030345)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of tooth enamel.
protein phosphatase 2B binding (GO:0030346)
Namespace: molecular_function
Definition: Binding to a protein phosphatase 2B.
Synonyms: calcineurin binding; protein phosphatase 3 binding
syntaxin-3 binding (GO:0030348)
Namespace: molecular_function
Definition: Binding to a syntaxin-3 SNAP receptor.
iron-responsive element binding (GO:0030350)
Namespace: molecular_function
Definition: Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins.
Synonyms: IRE binding
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity (GO:0030351)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate.
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity (GO:0030352)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate.
fibroblast growth factor receptor antagonist activity (GO:0030353)
Namespace: molecular_function
Definition: Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.
Synonyms: FGF receptor antagonist activity; FGFR antagonist activity
melanin-concentrating hormone activity (GO:0030354)
Namespace: molecular_function
Definition: The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.
obsolete small nucleolar ribonucleoprotein (GO:0030355)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: small nucleolar ribonucleoprotein; snoRNP
Comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
obsolete small cytoplasmic ribonucleoprotein (GO:0030356)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: scRNP; small cytoplasmic ribonucleoprotein
Comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
obsolete pre-mRNA cleavage factor activity (GO:0030363)
Namespace: molecular_function
Definition: OBSOLETE. Any activity required for the process of mRNA cleavage.
Synonyms: pre-mRNA cleavage factor activity
Comment: This term was made obsolete because it describes a biological process.
obsolete cleavage and polyadenylylation specificity factor activity (GO:0030364)
Namespace: molecular_function
Definition: OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions.
Synonyms: cleavage and polyadenylation specificity factor activity; cleavage and polyadenylylation specificity factor activity; cleavage/polyadenylation specificity factor activity; CPSF
Comment: This term was made obsolete because it describes a cellular component.
molybdopterin synthase activity (GO:0030366)
Namespace: molecular_function
Definition: Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.
interleukin-17 receptor activity (GO:0030368)
Namespace: molecular_function
Definition: Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-17 receptor activity; IL-17R
ICAM-3 receptor activity (GO:0030369)
Namespace: molecular_function
Definition: Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
intercellular adhesion molecule-3 receptor binding (GO:0030370)
Namespace: molecular_function
Definition: Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1.
Synonyms: ICAM-3 receptor binding; ICAM-3 receptor ligand; intercellular adhesion molecule-3 receptor ligand
translation repressor activity (GO:0030371)
Namespace: molecular_function
Definition: Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
high molecular weight B cell growth factor receptor binding (GO:0030372)
Namespace: molecular_function
Definition: Binding to a high molecular weight B cell growth factor receptor.
Synonyms: high molecular weight B cell growth factor receptor ligand; high molecular weight B lymphocyte growth factor receptor binding; high molecular weight B-cell growth factor receptor binding; high molecular weight B-lymphocyte growth factor receptor binding
high molecular weight B cell growth factor receptor activity (GO:0030373)
Namespace: molecular_function
Definition: Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity.
Synonyms: high molecular weight B lymphocyte growth factor receptor activity; high molecular weight B-cell growth factor receptor activity; high molecular weight B-lymphocyte growth factor receptor activity; HMW-BCGF receptor
obsolete nuclear receptor coactivator activity (GO:0030374)
Namespace: molecular_function
Definition: OBSOLETE. A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
Synonyms: ligand-activated RNA polymerase II transcription factor binding transcription factor activity; ligand-dependent nuclear receptor transcription co-activator activity; ligand-dependent nuclear receptor transcription coactivator activity; nuclear receptor transcription coactivator activity; transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
Comment: The reason for obsoletion is that these activities are not necessarily specific for nuclear receptors subclass of dbTFs, so that distinction leads to misannotations.
obsolete thyroid hormone receptor coactivator activity (GO:0030375)
Namespace: molecular_function
Definition: OBSOLETE. The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
Synonyms: thyroid hormone receptor activator activity; thyroid hormone receptor co-activator activity
Comment: This term was obsoleted because it represented a gene product.
serine racemase activity (GO:0030378)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-serine = D-serine.
neurotensin receptor activity, non-G protein-coupled (GO:0030379)
Namespace: molecular_function
Definition: Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins.
Synonyms: neurotensin receptor activity, non G protein coupled; neurotensin receptor activity, non-G-protein coupled; non G protein coupled neurotensin receptor activity; non-G-protein coupled neurotensin receptor activity; non-G-protein-coupled neurotensin receptor activity
interleukin-17E receptor binding (GO:0030380)
Namespace: molecular_function
Definition: Binding to an interleukin-17E receptor.
Synonyms: IL-17E; interleukin-17E receptor ligand
chorion-containing eggshell pattern formation (GO:0030381)
Namespace: biological_process
Definition: The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects.
sperm mitochondrion organization (GO:0030382)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm.
Synonyms: sperm mitochondria organisation; sperm mitochondria organization and biogenesis; sperm mitochondrion organization and biogenesis
obsolete host-pathogen interaction (GO:0030383)
Namespace: biological_process
Definition: OBSOLETE. Any interaction between a pathogen and its host organism.
Synonyms: host-pathogen interaction
Comment: This term was made obsolete because more appropriate terms were created.
ferredoxin-thioredoxin reductase complex (GO:0030386)
Namespace: cellular_component
Definition: A protein complex that possesses ferredoxin-thioredoxin reductase activity.
Synonyms: ferredoxin:thioredoxin reductase complex
Comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin-thioredoxin reductase activity ; GO:0103012'.
fructose 1,6-bisphosphate metabolic process (GO:0030388)
Namespace: biological_process
Definition: The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.
Synonyms: fructose 1,6-bisphosphate metabolism
fructosamine metabolic process (GO:0030389)
Namespace: biological_process
Definition: The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.
Synonyms: fructosamine metabolism
fructosamine biosynthetic process (GO:0030391)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.
Synonyms: fructosamine anabolism; fructosamine biosynthesis; fructosamine formation; fructosamine synthesis
fructosamine catabolic process (GO:0030392)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.
Synonyms: fructosamine breakdown; fructosamine catabolism; fructosamine degradation
fructoselysine metabolic process (GO:0030393)
Namespace: biological_process
Definition: The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group.
Synonyms: fructoselysine metabolism
obsolete fructoseglycine metabolic process (GO:0030394)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group.
Synonyms: fructoseglycine metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
lactose binding (GO:0030395)
Namespace: molecular_function
Definition: Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.
membrane disassembly (GO:0030397)
Namespace: biological_process
Definition: The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.
Synonyms: membrane breakdown; membrane catabolism; membrane degradation
obsolete peroxisomal membrane disassembly (GO:0030398)
Namespace: biological_process
Definition: OBSOLETE. The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation.
Synonyms: peroxisomal membrane breakdown; peroxisomal membrane catabolism; peroxisomal membrane degradation
Comment: This trerm was added in error
autophagosome membrane disassembly (GO:0030399)
Namespace: biological_process
Definition: The controlled breakdown of the membranes of autophagosomes.
Synonyms: autophagic membrane breakdown; autophagic membrane catabolism; autophagic membrane degradation; autophagic vacuole membrane disassembly
obsolete protease substrate recruitment factor activity (GO:0030400)
Namespace: molecular_function
Definition: OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity.
Synonyms: protease substrate recruitment factor activity
Comment: This term was made obsolete because it represents a gene product.
obsolete transcription antiterminator activity (GO:0030401)
Namespace: molecular_function
Definition: OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed.
Synonyms: transcription antiterminator activity; transcriptional antiterminator activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
obsolete matrilysin-2 activity (GO:0030402)
Namespace: molecular_function
Definition: OBSOLETE. Was not defined before being made obsolete.
Synonyms: matrilysin-2 activity; matrix metalloproteinase 26; MMP-26
Comment: This term was made obsolete because it represents a gene product.