LiteFold/GO huggingface dataset:
gamma-tubulin small complex (GO:0008275)
Namespace: cellular_component
Definition: A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.
Synonyms: gamma-tubulin small complex, centrosomal; gamma-tubulin small complex, mitotic spindle pole body; gamma-tubulin small complex, spindle pole body; gammaTuSC; Tub4 complex
protein methyltransferase activity (GO:0008276)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group (CH3-) to a protein.
Synonyms: protein methylase activity
regulation of G protein-coupled receptor signaling pathway (GO:0008277)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms: regulation of G protein coupled receptor protein signaling pathway; regulation of G protein coupled receptor protein signalling pathway; regulation of G-protein coupled receptor protein signaling pathway; regulation of G-protein coupled receptor protein signalling pathway; regulation of G-protein-coupled receptor protein signalling pathway; regulation of GPCR protein signaling pathway; regulation of GPCR protein signalling pathway
cohesin complex (GO:0008278)
Namespace: cellular_component
Definition: A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
Synonyms: 14S cohesin; 9S cohesin; cohesin core heterodimer; nuclear cohesin complex; SMC complex; SMC/kleisin ring complex; Smc1-Smc3 complex
sulfonylurea receptor activity (GO:0008281)
Namespace: molecular_function
Definition: Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: sulphonylurea receptor activity
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'.
inward rectifying potassium channel (GO:0008282)
Namespace: cellular_component
Definition: A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
Synonyms: ATP-sensitive potassium channel complex; inward rectifying K+ channel; KCNJ11-SUR complex; KCNJ11-SURx complex; KCNJ8-SUR complex; KCNJ8-SURx complex; Kir6-SUR complex; Kir6.1-SUR complex; Kir6.1-SURx complex; Kir6.2-SUR complex; Kir6.2-SURx complex; Kir6.x complex; Kir6.x-SURx complex
cell population proliferation (GO:0008283)
Namespace: biological_process
Definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
Synonyms: cell proliferation
Comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
positive regulation of cell population proliferation (GO:0008284)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of cell proliferation.
Synonyms: activation of cell proliferation; positive regulation of cell proliferation; stimulation of cell proliferation; up regulation of cell proliferation; up-regulation of cell proliferation; upregulation of cell proliferation
negative regulation of cell population proliferation (GO:0008285)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of cell proliferation.
Synonyms: down regulation of cell proliferation; down-regulation of cell proliferation; downregulation of cell proliferation; inhibition of cell proliferation; negative regulation of cell proliferation
insulin receptor signaling pathway (GO:0008286)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
Synonyms: daf-2 receptor signaling pathway; insulin receptor signalling pathway
protein serine/threonine phosphatase complex (GO:0008287)
Namespace: cellular_component
Definition: A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.
boss receptor activity (GO:0008288)
Namespace: molecular_function
Definition: Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
Synonyms: sevenless receptor activity
lipid binding (GO:0008289)
Namespace: molecular_function
Definition: Binding to a lipid.
F-actin capping protein complex (GO:0008290)
Namespace: cellular_component
Definition: A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.
acetylcholine metabolic process (GO:0008291)
Namespace: biological_process
Definition: The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.
Synonyms: acetylcholine metabolism
acetylcholine biosynthetic process (GO:0008292)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.
Synonyms: acetylcholine anabolism; acetylcholine biosynthesis; acetylcholine formation; acetylcholine synthesis
torso signaling pathway (GO:0008293)
Namespace: biological_process
Definition: The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: torso signalling pathway
calcium- and calmodulin-responsive adenylate cyclase activity (GO:0008294)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
Synonyms: calcium- and calmodulin-responsive adenylyl cyclase activity; calcium/calmodulin-responsive adenylate cyclase activity
spermidine biosynthetic process (GO:0008295)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
Synonyms: spermidine anabolism; spermidine biosynthesis; spermidine formation; spermidine synthesis
3'-5'-DNA exonuclease activity (GO:0008296)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.
Synonyms: 3'-5' exodeoxyribonuclease activity; 3'-5'-exodeoxyribonuclease activity
single-stranded DNA exodeoxyribonuclease activity (GO:0008297)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.
Synonyms: single-stranded DNA specific exodeoxyribonuclease activity; ssDNA-specific exodeoxyribonuclease activity
intracellular mRNA localization (GO:0008298)
Namespace: biological_process
Definition: Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
Synonyms: establishment and maintenance of intracellular RNA localization; intracellular mRNA localisation; intracellular mRNA positioning; mRNA localization, intracellular; mRNA positioning, intracellular
isoprenoid biosynthetic process (GO:0008299)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
Synonyms: isoprenoid anabolism; isoprenoid biosynthesis; isoprenoid formation; isoprenoid synthesis; polyisoprenoid anabolism; polyisoprenoid biosynthesis; polyisoprenoid biosynthetic process; polyisoprenoid formation; polyisoprenoid synthesis; polyterpene biosynthesis; polyterpene biosynthetic process
isoprenoid catabolic process (GO:0008300)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
Synonyms: isoprenoid breakdown; isoprenoid catabolism; isoprenoid degradation; polyisoprenoid breakdown; polyisoprenoid catabolic process; polyisoprenoid catabolism; polyisoprenoid degradation; polyterpene catabolic process; polyterpene catabolism
female germline ring canal formation, actin assembly (GO:0008302)
Namespace: biological_process
Definition: Recruitment and organization of actin filaments in female germline ring canals.
Synonyms: nurse cell ring canal formation, actin assembly; ovarian ring canal formation, actin assembly; ring canal formation, actin assembly
caspase complex (GO:0008303)
Namespace: cellular_component
Definition: A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes.
Synonyms: cysteine-type endopeptidase complex
Comment: Note that this term was reinstated from obsolete.
obsolete eukaryotic translation initiation factor 4 complex (GO:0008304)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: eIF-4; eukaryotic translation initiation factor 4 complex
Comment: This term was made obsolete because more specific terms were created.
integrin complex (GO:0008305)
Namespace: cellular_component
Definition: A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
Synonyms: laminin receptor protein
associative learning (GO:0008306)
Namespace: biological_process
Definition: Learning by associating a stimulus (the cause) with a particular outcome (the effect).
Synonyms: classical conditioning; conditional learning; conditional response; Pavlovian conditioning
double-stranded DNA exodeoxyribonuclease activity (GO:0008309)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule.
Synonyms: double-stranded DNA specific exodeoxyribonuclease activity
single-stranded DNA 3'-5' DNA exonuclease activity (GO:0008310)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.
Synonyms: exonuclease I activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; ssDNA-specific 3'-5' exodeoxyribonuclease activity
double-stranded DNA 3'-5' DNA exonuclease activity (GO:0008311)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule.
Synonyms: double-stranded DNA 3'-5' exodeoxyribonuclease activity; double-stranded DNA specific 3'-5' exodeoxyribonuclease activity; exonuclease III activity; exoribonuclease III activity
7S RNA binding (GO:0008312)
Namespace: molecular_function
Definition: Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
obsolete gurken-activated receptor activity (GO:0008313)
Namespace: molecular_function
Definition: OBSOLETE. Combining with the ligand Gurken to initiate a change in cell activity.
Synonyms: gurken receptor activity
Comment: This term was obsoleted because it represents a receptor by its ligand.
obsolete gurken signaling pathway (GO:0008314)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to a ligand Gurken.
Synonyms: gurken receptor signaling pathway; gurken receptor signalling pathway; gurken-activated signaling pathway; signaling by Gurken
Comment: The reason for obsoletion is that this term represents a gene product.
G2/MI transition of meiotic cell cycle (GO:0008315)
Namespace: biological_process
Definition: The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I.
Synonyms: meiotic cell cycle G2/MI phase transition; meiotic G2/MI phase transition; meiotic G2/MI transition
structural constituent of vitelline membrane (GO:0008316)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster.
obsolete gurken receptor binding (GO:0008317)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a gurken growth factor receptor.
Synonyms: gurken receptor ligand
Comment: The reason for obsoletion is that this term represents a gene product.
protein prenyltransferase activity (GO:0008318)
Namespace: molecular_function
Definition: Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein.
obsolete prenyl protein specific endopeptidase activity (GO:0008319)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: prenyl protein specific endopeptidase activity
Comment: This term was made obsolete because it represents a gene product.
transmembrane protein transporter activity (GO:0008320)
Namespace: molecular_function
Definition: Enables the transfer of a protein from one side of a membrane to the other.
Synonyms: protein channel activity; protein transmembrane transporter activity
obsolete Pro-X carboxypeptidase activity (GO:0008322)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid.
Synonyms: Pro-X carboxypeptidase activity
Comment: This term was made obsolete because it represents a gene product.
monoatomic cation transmembrane transporter activity (GO:0008324)
Namespace: molecular_function
Definition: Enables the transfer of cation from one side of a membrane to the other.
Synonyms: cation transmembrane transporter activity; transmembrane cation transporter activity
ionotropic glutamate receptor complex (GO:0008328)
Namespace: cellular_component
Definition: A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.
protein tyrosine/threonine phosphatase activity (GO:0008330)
Namespace: molecular_function
Definition: Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
high voltage-gated calcium channel activity (GO:0008331)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
Synonyms: high voltage gated calcium channel activity; high voltage-dependent calcium channel activity; L-type calcium channel; N-type calcium channel; P-type calcium channel; Q-type calcium channel
low voltage-gated calcium channel activity (GO:0008332)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.
Synonyms: low voltage gated calcium channel activity; low voltage-dependent calcium channel activity; T-type calcium channel
endosome to lysosome transport (GO:0008333)
Namespace: biological_process
Definition: The directed movement of substances from endosomes to lysosomes.
gamma-butyrobetaine dioxygenase activity (GO:0008336)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate.
Synonyms: 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating); alpha-butyrobetaine hydroxylase activity; butyrobetaine hydroxylase activity; g-butyrobetaine dioxygenase activity; gamma-BBH activity; gamma-butyrobetaine hydroxylase activity; gamma-butyrobetaine,2-oxoglutarate dioxygenase activity
obsolete selectin (GO:0008337)
Namespace: molecular_function
Definition: OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins.
Synonyms: selectin
Comment: This term was made obsolete because it describes a class of gene products.
determination of adult lifespan (GO:0008340)
Namespace: biological_process
Definition: The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
obsolete response to cocaine (sensu Insecta) (GO:0008341)
Namespace: biological_process
Definition: OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557).
Synonyms: response to cocaine (sensu Insecta)
Comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
obsolete larval feeding behavior (sensu Insecta) (GO:0008342)
Namespace: biological_process
Definition: OBSOLETE. Feeding behavior in an insect larva.
Synonyms: larval feeding behavior (sensu Insecta)
Comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
adult feeding behavior (GO:0008343)
Namespace: biological_process
Definition: Feeding behavior in a fully developed and mature organism.
Synonyms: adult feeding behaviour
Comment: See also the biological process term 'feeding behavior ; GO:0007631'.
adult locomotory behavior (GO:0008344)
Namespace: biological_process
Definition: Locomotory behavior in a fully developed and mature organism.
Synonyms: adult locomotory behaviour
Comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
larval locomotory behavior (GO:0008345)
Namespace: biological_process
Definition: Locomotory behavior in a larval (immature) organism.
Synonyms: larval locomotory behaviour
Comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
larval walking behavior (GO:0008346)
Namespace: biological_process
Definition: The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
Synonyms: larval walking behaviour
glial cell migration (GO:0008347)
Namespace: biological_process
Definition: The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
Synonyms: glia cell migration
negative regulation of antimicrobial humoral response (GO:0008348)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.
Synonyms: attenuation of antimicrobial humoral response; down regulation of antimicrobial humoral response; down-regulation of antimicrobial humoral response; downregulation of antimicrobial humoral response; inhibition of antimicrobial humoral response
MAP kinase kinase kinase kinase activity (GO:0008349)
Namespace: molecular_function
Definition: Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
Synonyms: MAP4K activity; MAPKKKK
obsolete kinetochore motor activity (GO:0008350)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: kinetochore motor activity
Comment: This term was made obsolete because it includes cellular component information.
obsolete microtubule severing activity (GO:0008351)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: microtubule severing activity
Comment: This term was made obsolete because it describes a biological process.
katanin complex (GO:0008352)
Namespace: cellular_component
Definition: A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).
Comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'.
RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.
Synonyms: [RNA-polymerase]-subunit kinase activity; CTD kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; RNA polymerase subunit kinase activity; RNA-polymerase-subunit kinase activity
germ cell migration (GO:0008354)
Namespace: biological_process
Definition: The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
Synonyms: germ-cell migration; pole cell migration; primordial germ cell migration
olfactory learning (GO:0008355)
Namespace: biological_process
Definition: Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
asymmetric cell division (GO:0008356)
Namespace: biological_process
Definition: The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
Synonyms: asymmetric cytokinesis; asymmetrical cell division; asymmetrical cytokinesis
maternal determination of anterior/posterior axis, embryo (GO:0008358)
Namespace: biological_process
Definition: The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.