LiteFold/GO huggingface dataset:
obsolete milk protein (GO:0005189)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: milk protein
Comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
obsolete seminal fluid protein (GO:0005190)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: seminal fluid protein
Comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
obsolete urinary protein (GO:0005192)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: urinary protein
Comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
obsolete major urinary protein (GO:0005193)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: major urinary protein
Comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
obsolete cell adhesion molecule activity (GO:0005194)
Namespace: molecular_function
Definition: OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix.
Synonyms: cell adhesion molecule activity
Comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion.
structural constituent of cell wall (GO:0005199)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a cell wall.
structural constituent of cytoskeleton (GO:0005200)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
extracellular matrix structural constituent (GO:0005201)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of the extracellular matrix.
Synonyms: core extracellular matrix; core matrisome; extracellular matrix glycoprotein
Comment: Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019
obsolete collagen (GO:0005202)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: collagen
Comment: This term was made obsolete because it does not represent a molecular function.
obsolete proteoglycan (GO:0005203)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: proteoglycan
Comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
obsolete chondroitin sulfate proteoglycan (GO:0005204)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: chondroitin sulfate proteoglycan; chondroitin sulphate proteoglycan
Comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
obsolete chondroitin sulfate/dermatan sulfate proteoglycan (GO:0005205)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: chondroitin sulfate/dermatan sulfate proteoglycan; chondroitin sulphate/dermatan sulphate proteoglycan
Comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
obsolete heparin sulfate proteoglycan (GO:0005206)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: heparin sulfate proteoglycan; heparin sulphate proteoglycan
Comment: This term was made obsolete because it represents a gene product.
obsolete extracellular matrix glycoprotein (GO:0005207)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: extracellular matrix glycoprotein
Comment: This term was made obsolete because it describes localization and modification rather than activity.
obsolete amyloid protein (GO:0005208)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: amyloid protein
Comment: This term was made obsolete because it represents a gene product.
obsolete plasma protein (GO:0005209)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: plasma protein
Comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
obsolete plasma glycoprotein (GO:0005211)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: plasma glycoprotein
Comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
structural constituent of eye lens (GO:0005212)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of the lens of an eye.
structural constituent of egg chorion (GO:0005213)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster.
Synonyms: structural constituent of chorion; structural protein of chorion
structural constituent of chitin-based cuticle (GO:0005214)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster.
transporter activity (GO:0005215)
Namespace: molecular_function
Definition: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
Synonyms: carrier
Comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.
monoatomic ion channel activity (GO:0005216)
Namespace: molecular_function
Definition: Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
Synonyms: ion channel activity
intracellularly ligand-gated monoatomic ion channel activity (GO:0005217)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
Synonyms: intracellular ligand-gated ion channel activity; intracellular ligand-gated monoatomic ion channel activity
ryanodine-sensitive calcium-release channel activity (GO:0005219)
Namespace: molecular_function
Definition: Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine.
Synonyms: caffeine-sensitive calcium-release channel; ryanodine receptor
inositol 1,4,5-trisphosphate-gated calcium channel activity (GO:0005220)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.
Synonyms: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; inositol-1,4,5-trisphosphate receptor activity; InsP3 receptor; IP3 receptor activity
intracellularly cyclic nucleotide-activated monoatomic cation channel activity (GO:0005221)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.
Synonyms: intracellular cyclic nucleotide activated cation channel activity; intracellular cyclic nucleotide activated monoatomic cation channel activity; intracellular cyclic nucleotide-activated monoatomic cation channel activity
intracellularly cAMP-activated cation channel activity (GO:0005222)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.
Synonyms: HCN channel activity; hyperpolarization-activated cyclic nucleotide-gated channel activity; intracellular 3',5' cAMP activated cation channel activity; intracellular 3',5'-cAMP activated cation channel activity; intracellular adenosine 3',5'-cyclophosphate activated cation channel activity; intracellular cAMP activated cation channel activity; intracellular cAMP-activated cation channel activity; intracellular cyclic AMP activated cation channel activity
intracellularly cGMP-activated cation channel activity (GO:0005223)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.
Synonyms: intracellular cGMP activated cation channel activity; intracellular cGMP-activated cation channel activity
volume-sensitive anion channel activity (GO:0005225)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.
Synonyms: volume-regulated channel
calcium-activated cation channel activity (GO:0005227)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an inorganic cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts.
Synonyms: calcium activated cation channel activity; intracellular calcium-activated potassium channel; polycystin
intracellular sodium-activated potassium channel activity (GO:0005228)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification.
Synonyms: intracellular sodium activated potassium channel activity
intracellularly calcium-gated chloride channel activity (GO:0005229)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
Synonyms: intracellular calcium activated chloride channel activity
extracellular ligand-gated monoatomic ion channel activity (GO:0005230)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
Synonyms: extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated monoatomic ion channel activity (GO:0005231)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
extracellularly glutamate-gated ion channel activity (GO:0005234)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms: extracellular-glutamate-gated ion channel activity
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
inhibitory extracellular ligand-gated monoatomic ion channel activity (GO:0005237)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.
Synonyms: inhibitory extracellular ligand-gated ion channel activity
obsolete glycine receptor-associated protein (GO:0005240)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: glycine receptor-associated protein
Comment: This term was made obsolete because it does not describe a molecular function.
obsolete inward rectifier channel (GO:0005241)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: inward rectifier channel
Comment: This term was made obsolete because more specific terms were created.
inward rectifier potassium channel activity (GO:0005242)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
Synonyms: Kir channel activity
gap junction channel activity (GO:0005243)
Namespace: molecular_function
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms: connexin; innexin; innexin channel activity; intercellular channel
voltage-gated monoatomic ion channel activity (GO:0005244)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage gated ion channel activity; voltage-dependent ion channel activity; voltage-gated ion channel activity
voltage-gated calcium channel activity (GO:0005245)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: depolarization-activated calcium channel; depolarization-activated voltage gated calcium channel activity; depolarization-activated voltage-gated calcium channel; depolarization-activated voltage-gated calcium channel activity; dihydropyridine-sensitive calcium channel activity; voltage gated calcium channel activity; voltage-dependent calcium channel activity; voltage-gated calcium ion channel activity; voltage-sensitive calcium channel
voltage-gated chloride channel activity (GO:0005247)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage gated chloride channel activity; voltage-dependent chloride channel activity
voltage-gated sodium channel activity (GO:0005248)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage gated sodium channel activity; voltage-dependent sodium channel activity; voltage-gated sodium ion channel activity; voltage-sensitive sodium channel
voltage-gated potassium channel activity (GO:0005249)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage gated potassium channel activity; voltage-dependent potassium channel activity; voltage-gated potassium ion channel activity; voltage-sensitive potassium channel
A-type (transient outward) potassium channel activity (GO:0005250)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.
delayed rectifier potassium channel activity (GO:0005251)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
open rectifier potassium channel activity (GO:0005252)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration.
monoatomic anion channel activity (GO:0005253)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel.
Synonyms: anion channel activity; non-selective anion channel activity
intracellularly ATP-gated chloride channel activity (GO:0005260)
Namespace: molecular_function
Definition: Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
Synonyms: CFTR; channel-conductance-controlling ATPase activity; cystic fibrosis transmembrane conductance regulator
Comment: This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
calcium channel activity (GO:0005262)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel.
potassium channel activity (GO:0005267)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel.
sodium channel activity (GO:0005272)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel.
allantoin:proton symporter activity (GO:0005274)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport.
Synonyms: allantoin permease activity; allantoin uptake transmembrane transporter activity; allantoin/allantoate transporter
amine transmembrane transporter activity (GO:0005275)
Namespace: molecular_function
Definition: Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.
Synonyms: amine/amide/polyamine channel activity; amine/polyamine transmembrane transporter activity; amino acid-polyamine transmembrane transporter activity
obsolete vesicular amino acid:proton antiporter activity (GO:0005276)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in).
Synonyms: hydrogen:vesicular amine antiporter activity; vesicular hydrogen:amino acid antiporter activity
Comment: The reason for obsoletion is that the cellular component does not belong is the MF according to the documentation: http://wiki.geneontology.org/index.php/Transporter_terms_standard_definitions
acetylcholine transmembrane transporter activity (GO:0005277)
Namespace: molecular_function
Definition: Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.
acetylcholine:proton antiporter activity (GO:0005278)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out).
Synonyms: acetylcholine:hydrogen antiporter activity
amino acid:proton symporter activity (GO:0005280)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in).
Synonyms: cation/amino acid symporter; hydrogen:amino acid symporter activity
obsolete general amino acid permease activity (GO:0005281)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: general amino acid permease activity; general amino acid transporter
Comment: This term was made obsolete because it represents a gene product.
amino acid:sodium symporter activity (GO:0005283)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
Synonyms: glutamate/aspartate:sodium symporter activity; insulin-activated sodium/amino acid transporter activity; insulin-activated sodium:amino acid symporter activity; insulin-activated sodium:amino acid transporter activity; isoleucine/valine:sodium symporter activity; sodium/amino acid transporter activity; sodium/excitatory amino acid cotransporter activity; sodium/excitatory amino acid symporter activity; sodium:amino acid symporter activity; sodium:amino acid transporter activity; threonine/serine:sodium symporter activity