LiteFold/GO huggingface dataset:
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (GO:0071879)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the adenylate cyclase-activating adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.
Synonyms: positive regulation of adrenergic receptor signaling pathway; positive regulation of adrenergic receptor signalling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway (GO:0071880)
Namespace: biological_process
Definition: An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
Synonyms: activation of adenylate cyclase activity by adrenergic receptor signaling pathway; activation of adenylate cyclase activity by adrenergic receptor signalling pathway; adrenergic receptor, adenylate cyclase activating pathway; adrenergic receptor, adenylyl cyclase activating pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway (GO:0071881)
Namespace: biological_process
Definition: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor, and ending with the regulation of a downstream cellular process.
Synonyms: adrenergic receptor, adenylate cyclase inhibiting pathway; adrenergic receptor, adenylyl cyclase inhibiting pathway; inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway; inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway
phospholipase C-activating adrenergic receptor signaling pathway (GO:0071882)
Namespace: biological_process
Definition: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: activation of phospholipase C activity by adrenergic receptor signaling pathway; activation of phospholipase C activity by adrenergic receptor signalling pathway; adrenergic receptor, phospholipase C activating pathway
MAPK-activating adrenergic receptor signaling pathway (GO:0071883)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade.
Synonyms: activation of MAP kinase activity by adrenergic receptor signaling pathway; activation of MAP kinase activity by adrenergic receptor signalling pathway; activation of MAPK activity by adrenergic receptor signaling pathway; activation of MAPK activity by adrenergic receptor signalling pathway
N-terminal protein N-methyltransferase activity (GO:0071885)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
Synonyms: X-Pro-Lys N-terminal methyltransferase
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding (GO:0071886)
Namespace: molecular_function
Definition: Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug.
Synonyms: (+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding; 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding; 4-iodo-2,5-dimethoxyphenylisopropylamine binding
macrophage apoptotic process (GO:0071888)
Namespace: biological_process
Definition: Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues.
Synonyms: activation-induced cell death; AICD; macrophage apoptosis
Comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
14-3-3 protein binding (GO:0071889)
Namespace: molecular_function
Definition: Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
bicarbonate binding (GO:0071890)
Namespace: molecular_function
Definition: Binding to bicarbonate ions (CHO3-).
Synonyms: CHO3- ion binding binding; hydrogencarbonate binding
obsolete N-terminal peptidyl-proline dimethylation involved in translation (GO:0071891)
Namespace: biological_process
Definition: OBSOLETE. An N-terminal peptidyl-proline dimethylation process that contributes to translation.
Comment: This term was obsoleted because it represents a molecular function.
thrombocyte activation (GO:0071892)
Namespace: biological_process
Definition: A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals.
Synonyms: blood coagulation, thrombocyte activation
obsolete BMP signaling pathway involved in nephric duct formation (GO:0071893)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to its receptor on the surface of a target cell, which contributes to nephric duct formation.
Synonyms: BMP signalling pathway involved in nephric duct formation
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete histone H2B conserved C-terminal lysine ubiquitination (GO:0071894)
Namespace: biological_process
Definition: OBSOLETE. A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals.
Synonyms: budding yeast H2B K123 ubiquitination; fission yeast H2B K119 ubiquitination; mammalian H2B K120 ubiquitination
Comment: This term was obsoleted because it represents a molecular function.
protein localization to adherens junction (GO:0071896)
Namespace: biological_process
Definition: Any process in which a protein is transported to, and/or maintained at the adherens junction.
Synonyms: protein localisation in adherens junction; protein localisation in cell-cell adherens junction; protein localisation to adherens junction; protein localisation to cell-cell adherens junction; protein localization in adherens junction; protein localization in cell-cell adherens junction; protein localization to cell-cell adherens junction
DNA biosynthetic process (GO:0071897)
Namespace: biological_process
Definition: The biosynthetic process resulting in the formation of DNA.
Synonyms: DNA anabolism; DNA biosynthesis; DNA formation; DNA synthesis
obsolete regulation of estrogen receptor binding (GO:0071898)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of estrogen receptor binding, interacting selectively with a an estrogen receptor.
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of estrogen receptor binding (GO:0071899)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor.
Comment: This term was obsoleted because it represents a molecular function.
regulation of protein serine/threonine kinase activity (GO:0071900)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity.
negative regulation of protein serine/threonine kinase activity (GO:0071901)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
positive regulation of protein serine/threonine kinase activity (GO:0071902)
Namespace: biological_process
Definition: Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
obsolete protein N-linked N-acetylglucosaminylation via asparagine (GO:0071903)
Namespace: biological_process
Definition: OBSOLETE. A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue.
Synonyms: protein amino acid N-linked N-acetylglucosaminylation via asparagine
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein N-linked N-acetylgalactosaminylation via asparagine (GO:0071904)
Namespace: biological_process
Definition: OBSOLETE. A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue.
Synonyms: protein amino acid N-linked N-acetylgalactosaminylation via asparagine
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein N-linked glucosylation via asparagine (GO:0071905)
Namespace: biological_process
Definition: OBSOLETE. A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue.
Synonyms: protein amino acid N-linked glucosylation via asparagine
Comment: This term was obsoleted because it represents a molecular function.
CRD domain binding (GO:0071906)
Namespace: molecular_function
Definition: Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins.
Synonyms: context dependent regulatory domain binding
determination of digestive tract left/right asymmetry (GO:0071907)
Namespace: biological_process
Definition: Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed.
Synonyms: determination of gut left/right asymmetry; determination of left/right asymmetry of the digestive tract
determination of intestine left/right asymmetry (GO:0071908)
Namespace: biological_process
Definition: Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism.
determination of stomach left/right asymmetry (GO:0071909)
Namespace: biological_process
Definition: Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism.
determination of liver left/right asymmetry (GO:0071910)
Namespace: biological_process
Definition: Determination of the asymmetric location of the liver with respect to the left and right halves of the organism.
synchronous neurotransmitter secretion (GO:0071911)
Namespace: biological_process
Definition: Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion.
asynchronous neurotransmitter secretion (GO:0071912)
Namespace: biological_process
Definition: Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion.
citrate secondary active transmembrane transporter activity (GO:0071913)
Namespace: molecular_function
Definition: Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: citrate carrier activity
obsolete protein-lysine lysylation (GO:0071915)
Namespace: biological_process
Definition: OBSOLETE. The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P).
Synonyms: protein amino acid lysylation
Comment: This term was obsoleted because it represents a molecular function.
dipeptide transmembrane transporter activity (GO:0071916)
Namespace: molecular_function
Definition: Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.
Synonyms: dipeptide transporter activity
triose-phosphate transmembrane transporter activity (GO:0071917)
Namespace: molecular_function
Definition: Enables the transfer of a triose phosphate from one side of a membrane to the other.
G-quadruplex DNA formation (GO:0071919)
Namespace: biological_process
Definition: A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature.
Synonyms: G quadruplex DNA formation; G quartet DNA formation; G-quartet DNA formation
obsolete cohesin loading (GO:0071921)
Namespace: biological_process
Definition: OBSOLETE. The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA.
Synonyms: cohesin association with chromatin; cohesin localisation to chromatin; cohesin localization to chromatin
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete regulation of cohesin loading (GO:0071922)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
Synonyms: regulation of cohesin association with chromatin; regulation of cohesin localisation to chromatin; regulation of cohesin localization to chromatin
Comment: The reason for obsoletion is that this term represents the regulation of a molecular function.
chemokine (C-C motif) ligand 22 production (GO:0071924)
Namespace: biological_process
Definition: The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: C-C motif chemokine 22 production; CCL-22 production; CCL22 production
thymic stromal lymphopoietin production (GO:0071925)
Namespace: biological_process
Definition: The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: TSLP production
endocannabinoid signaling pathway (GO:0071926)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol.
Synonyms: endocannabinoid signalling pathway
octopamine signaling pathway (GO:0071927)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor.
Synonyms: octopamine signalling pathway
alpha-tubulin acetylation (GO:0071929)
Namespace: biological_process
Definition: The addition of an acetyl group to the lysine 40 residue of alpha-tubulin.
obsolete negative regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0071930)
Namespace: biological_process
Definition: OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle.
Synonyms: negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete positive regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0071931)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle.
Synonyms: positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle
Comment: This term was obsoleted because it represents a GO-CAM model.
replication fork reversal (GO:0071932)
Namespace: biological_process
Definition: Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved.
Arp2/3 complex binding (GO:0071933)
Namespace: molecular_function
Definition: Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
thiamine transmembrane transport (GO:0071934)
Namespace: biological_process
Definition: The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.
Synonyms: thiamin transmembrane transport; thiamine membrane transport; vitamin B1 transmembrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
obsolete coreceptor activity involved in Wnt signaling pathway (GO:0071936)
Namespace: molecular_function
Definition: OBSOLETE. In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway.
Synonyms: coreceptor activity involved in Wnt receptor signaling pathway; coreceptor activity involved in Wnt receptor signalling pathway; coreceptor activity involved in Wnt-activated signaling pathway; Wnt co-receptor activity
Comment: Precomposed term that should be captured as GO-CAMs or extension.
vitamin A transport (GO:0071938)
Namespace: biological_process
Definition: The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.
Synonyms: vitamin A uptake and transport
vitamin A import into cell (GO:0071939)
Namespace: biological_process
Definition: The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.
Synonyms: vitamin A import; vitamin A uptake
fungal-type cell wall assembly (GO:0071940)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall.
Synonyms: fungal-type cell wall formation
nitrogen cycle metabolic process (GO:0071941)
Namespace: biological_process
Definition: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
XPC complex (GO:0071942)
Namespace: cellular_component
Definition: A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2.
Myc-Max complex (GO:0071943)
Namespace: cellular_component
Definition: A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max.
regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed (GO:0071945)
Namespace: biological_process
Definition: A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein.
Synonyms: regulation of bacterial-type flagellar cell motility by regulation of motor speed; regulation of bacterial-type flagellum cell motility by regulation of motor speed; regulation of flagellar cell motility by regulation of motor speed
cis-acting DNA replication termination (GO:0071946)
Namespace: biological_process
Definition: A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing.
Synonyms: cis acting DNA replication termination
protein deubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0071947)
Namespace: biological_process
Definition: The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism.
activation-induced B cell apoptotic process (GO:0071948)
Namespace: biological_process
Definition: B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death.
Synonyms: activated B cell apoptosis; activation-induced B cell apoptosis; activation-induced B-cell apoptosis; activation-induced cell death of B cells; activation-induced cell death of B lymphocytes; activation-induced cell death of B-cells; activation-induced cell death of B-lymphocytes; AICD; antigen-driven apoptosis
FAD binding (GO:0071949)
Namespace: molecular_function
Definition: Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
Synonyms: oxidized flavin adenine dinucleotide binding; oxidized flavine-adenine dinucleotide binding
FADH2 binding (GO:0071950)
Namespace: molecular_function
Definition: Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
Synonyms: reduced flavin adenine dinucleotide binding; reduced flavine-adenine dinucleotide binding