LiteFold/GO huggingface dataset:
magnesium:sodium antiporter activity (GO:0061768)
Namespace: molecular_function
Definition: Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in).
nicotinate riboside kinase activity (GO:0061769)
Namespace: molecular_function
Definition: Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide.
Synonyms: nicotinic acid riboside kinase activity; ribosylnicotinate kinase activity; ribosylnicotinic acid kinase activity
translation elongation factor binding (GO:0061770)
Namespace: molecular_function
Definition: Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.
response to caloric restriction (GO:0061771)
Namespace: biological_process
Definition: A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake.
xenobiotic transport across blood-nerve barrier (GO:0061772)
Namespace: biological_process
Definition: The directed movement of a xenobiotic through the blood-nerve barrier.
Synonyms: drug transport across blood-nerve barrier; drug transport across perineurial barrier
eNoSc complex (GO:0061773)
Namespace: cellular_component
Definition: A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation.
Synonyms: energy dependent nucleolar silencing complex
obsolete cohesin unloading (GO:0061774)
Namespace: biological_process
Definition: OBSOLETE. Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA.
Synonyms: DNA exit from the cohesin ring
Comment: The reason for obsoletion is that this term represents a molecular function.
cohesin loader activity (GO:0061775)
Namespace: molecular_function
Definition: Facilitating a conformational change to load a cohesin complex around sister chromatids.
Synonyms: cohesin loading activity
ATP-dependent topological DNA co-entrapment activity (GO:0061776)
Namespace: molecular_function
Definition: A DNA binding activity in which a protein complex interacts with at least one DNA duplex to encircle the DNA molecules with a loose fitting ring.
Synonyms: ATP-dependent ring closure activity; topological DNA entrapment activity
obsolete DNA clamp activity (GO:0061777)
Namespace: molecular_function
Definition: OBSOLETE. A DNA binding activity in which a protein complex interacts selectively and non-covalently with single DNA duplex to tightly encircle the DNA.
Comment: The reason for obsoletion is that the term captures the structure of a complex, not a specific function.
Tapasin-ERp57 complex (GO:0061779)
Namespace: cellular_component
Definition: Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role.
obsolete mitotic cohesin loading (GO:0061780)
Namespace: biological_process
Definition: OBSOLETE. The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle.
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete mitotic cohesin unloading (GO:0061781)
Namespace: biological_process
Definition: OBSOLETE. Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA as part of the mitotic cell cycle.
Comment: The reason for obsoletion is that this term represents a molecular function.
vesicle fusion with vesicle (GO:0061782)
Namespace: biological_process
Definition: Fusion of the membrane of a transport vesicle with a target membrane on another vesicle.
Synonyms: vesicle to vesicle fusion; vesicle-vesicle fusion
peptidoglycan muralytic activity (GO:0061783)
Namespace: molecular_function
Definition: A catalytic activity that contributes to the degradation of peptidoglycan.
peptidoglycan N-acetylglucosaminidase activity (GO:0061784)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan.
peptidoglycan endopeptidase activity (GO:0061785)
Namespace: molecular_function
Definition: An endopeptidase activity that uses peptidoglycan as a substrate.
peptidoglycan stem peptide endopeptidase activity (GO:0061786)
Namespace: molecular_function
Definition: A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan.
peptidoglycan cross-bridge peptide endopeptidase activity (GO:0061787)
Namespace: molecular_function
Definition: A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge.
Synonyms: lysostaphin activity
EGF repeat binding (GO:0061788)
Namespace: molecular_function
Definition: Binding to Epidermal Growth Factor (EGF) repeats.
Synonyms: Epidermal growth factor domain binding; Epidermal Growth Factor repeat binding
dense core granule priming (GO:0061789)
Namespace: biological_process
Definition: A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking.
Synonyms: dense core vesicle priming; large dense-core vesicle priming; LDCV priming
dense core granule docking (GO:0061790)
Namespace: biological_process
Definition: The initial attachment of a dense core granule membrane to the plasma membrane.
GTPase motor activity (GO:0061791)
Namespace: molecular_function
Definition: A motor activity driven by GTP hydrolysis.
secretory granule maturation (GO:0061792)
Namespace: biological_process
Definition: Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling.
chromatin lock complex (GO:0061793)
Namespace: cellular_component
Definition: A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping.
Synonyms: nucleosome bridging complex
conidium development (GO:0061794)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of conidium over time, from its formation to the mature structure. Conidia are non-motile spores produced via mitotic asexual reproduction in higher fungi; they are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.
Golgi lumen acidification (GO:0061795)
Namespace: biological_process
Definition: Any process that reduces the pH of the Golgi lumen, corresponding to an increase in hydrogen ion concentration.
Synonyms: Golgi apparatus lumen acidification
membrane addition at site of mitotic cytokinesis (GO:0061796)
Namespace: biological_process
Definition: A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.
pH-gated chloride channel activity (GO:0061797)
Namespace: molecular_function
Definition: A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH.
GTP 3',8'-cyclase activity (GO:0061798)
Namespace: molecular_function
Definition: Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
cyclic pyranopterin monophosphate synthase activity (GO:0061799)
Namespace: molecular_function
Definition: Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.
fibronectin fibril (GO:0061800)
Namespace: cellular_component
Definition: A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks.
anterior cell cortex (GO:0061802)
Namespace: cellular_component
Definition: The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis.
posterior cell cortex (GO:0061803)
Namespace: cellular_component
Definition: The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis.
mitotic spindle elongation (spindle phase three) (GO:0061805)
Namespace: biological_process
Definition: The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B.
Synonyms: mitotic anaphase spindle elongation; mitotic spindle elongation during anaphase; mitotic spindle elongation during mitotic anaphase
regulation of DNA recombination at centromere (GO:0061806)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA.
Synonyms: regulation of centromeric recombination
negative regulation of DNA recombination at centromere (GO:0061808)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere.
Synonyms: negative regulation of centromeric recombination
NAD+ nucleosidase activity, cyclic ADP-ribose generating (GO:0061809)
Namespace: molecular_function
Definition: Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+, in a two step reaction: first an ADP-ribosyl cyclase reaction to synthesise cyclic ADP-ribose, followed by a cyclic ADP-ribose hydrolase reaction to generate (linear) ADP-ribose.
Synonyms: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; NAD hydrolase; NAD(+) nucleosidase; NADase; nicotinamide adenine dinucleotide nucleosidase
obsolete NAD glycohydrolase activity (GO:0061810)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate.
Comment: This term was obsoleted because it represents the same activity as NAD(P)+ nucleosidase activity ; GO:0050135.
obsolete ADP-ribosyl cyclase activity (GO:0061811)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide.
Comment: This term was obsoleted because it represents a step in a multi-step reaction.
obsolete cyclic ADP-ribose hydrolase (GO:0061812)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR).
Comment: This term was obsoleted because it represents a step in a multi-step reaction.
obsolete ARID domain binding (GO:0061813)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a ARID domain. The AT-rich interaction domain (ARID) is an ~100-amino acid DNA-binding module found in a large number of eukaryotic transcription factors.
Met1-linked polyubiquitin deubiquitinase activity (GO:0061815)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains.
Synonyms: cysteine-type deubiquitinase activity, acting on linear ubiquitin; deubiquitinase, acting on linear ubiquitin; linear ubiquitin specific deubiquitinase activity; Met1 linkage specific DUB; ubiquitinyl hydrolase activity, acting on linear ubiquitin
proteaphagy (GO:0061816)
Namespace: biological_process
Definition: The selective degradation of proteasomes by macroautophagy.
endoplasmic reticulum-plasma membrane tethering (GO:0061817)
Namespace: biological_process
Definition: The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.
Synonyms: ER-plasma membrane tethering
tRNA folding (GO:0061818)
Namespace: biological_process
Definition: The process of assisting in the folding of tRNAs into the correct tertiary structure.
telomeric DNA-containing double minutes formation (GO:0061819)
Namespace: biological_process
Definition: A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase.
Synonyms: TDMs formation
telomeric D-loop binding (GO:0061821)
Namespace: molecular_function
Definition: Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.
Synonyms: telomeric Displacement-loop binding
ciliary cap (GO:0061822)
Namespace: cellular_component
Definition: An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole.
Synonyms: spermatid ciliary cap
ring centriole (GO:0061823)
Namespace: cellular_component
Definition: A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum.
cytosolic ciliogenesis (GO:0061824)
Namespace: biological_process
Definition: The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.
Synonyms: intracellular ciliogenesis
podosome core (GO:0061825)
Namespace: cellular_component
Definition: The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell.
podosome ring (GO:0061826)
Namespace: cellular_component
Definition: The ring structure surrounding the podosome core, containing proteins such as vinculin and talin.
sperm head (GO:0061827)
Namespace: cellular_component
Definition: The part of the late spermatid or spermatozoon that contains the nucleus and acrosome.
apical tubulobulbar complex (GO:0061828)
Namespace: cellular_component
Definition: Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell.
Synonyms: apical TBC
basal tubulobulbar complex (GO:0061829)
Namespace: cellular_component
Definition: Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell.
Synonyms: basal TBC
concave side of sperm head (GO:0061830)
Namespace: cellular_component
Definition: The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species.
apical ectoplasmic specialization (GO:0061831)
Namespace: cellular_component
Definition: Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell.
Synonyms: apical ES
basal ectoplasmic specialization (GO:0061832)
Namespace: cellular_component
Definition: Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell.
Synonyms: basal ES
protein localization to tricellular tight junction (GO:0061833)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction.
actin filament branch point (GO:0061834)
Namespace: cellular_component
Definition: The part of an actin filament where the structure forks.
Synonyms: microfilament branch point
intranuclear rod (GO:0061836)
Namespace: cellular_component
Definition: A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions.
Synonyms: intranuclear actin rod
neuropeptide processing (GO:0061837)
Namespace: biological_process
Definition: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide.
CENP-T-W-S-X complex (GO:0061838)
Namespace: cellular_component
Definition: A histone-variant containing protein complex which forms a centromere specific nucleosome-like structure, involved in centromeric chromatin organization.
high-affinity ferrous iron transmembrane transporter activity (GO:0061840)
Namespace: molecular_function
Definition: Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity ferrous uptake transmembrane transporter activity; high-affinity ferrous iron uptake transmembrane transporter activity
high-affinity iron exporter complex (GO:0061841)
Namespace: cellular_component
Definition: A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment.
Synonyms: FET5-FTH1 high affinity iron exporter complex; FET5-FTH1 high-affinity iron exporter complex; high affinity iron exporter complex
Comment: An example of this is FET5 in Saccharomyces cerevisiae (P43561) in PMID:9413439.
microtubule organizing center localization (GO:0061842)
Namespace: biological_process
Definition: Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell.
Synonyms: microtubule organizing center polarity; MTOC localization; MTOC polarity
Sertoli cell barrier remodeling (GO:0061843)
Namespace: biological_process
Definition: The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle.
Synonyms: blood testis barrier restructuring; restructuring of blood-testis barrier; restructuring of BTB; restructuring of SCB; SCB remodeling; Sertoli cell barrier remodelling; Sertoli cell barrier restructuring
antimicrobial humoral immune response mediated by antimicrobial peptide (GO:0061844)
Namespace: biological_process
Definition: An immune response against microbes mediated by anti-microbial peptides in body fluid.
Synonyms: antimicrobial peptide-mediated antimicrobial humoral response; peptide-mediated antimicrobial humoral response
dendritic spine cytoplasm (GO:0061846)
Namespace: cellular_component
Definition: The region of the neuronal cytoplasm located in dendritic spines.
response to cholecystokinin (GO:0061847)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus.
cellular response to cholecystokinin (GO:0061848)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus.
telomeric G-quadruplex DNA binding (GO:0061849)
Namespace: molecular_function
Definition: Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres.
growth cone leading edge (GO:0061850)
Namespace: cellular_component
Definition: That part of the growth cone which represents the distal part of the structure.
leading edge of lamellipodium (GO:0061851)
Namespace: cellular_component
Definition: That part of the lamellipodium which represents the distal part of the structure.
retrograde transporter complex, Golgi to ER (GO:0061852)
Namespace: cellular_component
Definition: Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.
Synonyms: ERV41-ERV46 retrograde receptor complex; retrograde receptor complex, Golgi to endoplasmic reticulum; retrograde receptor complex, Golgi to ER; retrograde transporter complex, Golgi to endoplasmic reticulum
Comment: An example of this is ERV41 in Saccharomyces cerevisiae (Q04651) in PMID:16093310 (inferred from direct assay).
regulation of neuroblast migration (GO:0061853)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of neuroblast migration.
positive regulation of neuroblast migration (GO:0061854)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of neuroblast migration.
negative regulation of neuroblast migration (GO:0061855)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.
Golgi calcium ion transmembrane transport (GO:0061856)
Namespace: biological_process
Definition: A process in which a calcium ion is transported from one side of a Golgi membrane to the other by means of some agent such as a transporter or pore.
endoplasmic reticulum stress-induced pre-emptive quality control (GO:0061857)
Namespace: biological_process
Definition: The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.
Synonyms: ER pQC; ER stress-indiced pre-emptive quality control
DNA clamp unloader activity (GO:0061860)
Namespace: molecular_function
Definition: Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis.
Synonyms: DNA clamp unloading activity
cellular response to differentiation-inducing factor 2 (GO:0061862)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus.
Synonyms: cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one; cellular response to DIF-2; cellular response to DIF2
microtubule plus end polymerase activity (GO:0061863)
Namespace: molecular_function
Definition: Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversible depending on the availability of dimers.
basement membrane constituent secretion (GO:0061864)
Namespace: biological_process
Definition: The controlled release of molecules that form the basement membrane, including carbohydrates and glycoproteins by a cell.