LiteFold/GO huggingface dataset:
obsolete peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine (GO:0018234)
Namespace: biological_process
Definition: OBSOLETE. The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase.
Comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
obsolete peptidyl-lysine carboxylation (GO:0018235)
Namespace: biological_process
Definition: OBSOLETE. The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine.
Comment: This term was obsoleted because it represents a molecular function.
urease activator activity (GO:0018237)
Namespace: molecular_function
Definition: Increases the activity of urease by promoting the incorporation of nickel into the active site.
Synonyms: urease activase activity
obsolete peptidyl-lysine carboxyethylation (GO:0018238)
Namespace: biological_process
Definition: OBSOLETE. The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine.
Synonyms: protein amino acid carboxyethylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein S-linked glycosylation via cysteine (GO:0018240)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine.
Synonyms: protein amino acid S-linked glycosylation via cysteine
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete protein O-linked glycosylation via hydroxylysine (GO:0018241)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine.
Synonyms: protein amino acid O-linked glycosylation via hydroxylysine
Comment: for obsoletion is that this term represents a molecular function.
obsolete protein O-linked glycosylation via serine (GO:0018242)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine.
Synonyms: protein amino acid O-linked glycosylation via serine
Comment: This term was obsoleted because it did not represent a specific process. It may correspond to protein O-linked galactosylation; GO:0180062, protein O-linked xylosylation ; GO:0180064, protein O-linked glucosylation ; GO:0180059, and protein O-linked GFucNAcylation, all of which may be linked to a serine in a protein.
obsolete protein O-linked glycosylation via threonine (GO:0018243)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine.
Synonyms: protein amino acid O-linked glycosylation via threonine
Comment: This term was obsoleted because it did not represent a specific process. It may correspond to protein O-linked GalNAcylation ; GO:0016266, protein O-linked glucosylation ; GO:0180059, protein O-linked galactosylation; GO:0180062, or protein O-linked mannosylation ; GO:0035269, all of which may be linked to a threonine in a protein.
obsolete protein N-linked glycosylation via tryptophan (GO:0018244)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue.
Comment: This term was obsoleted because it represents a molecular function.
protein-coenzyme A linkage (GO:0018246)
Namespace: biological_process
Definition: The formation of a linkage between a protein amino acid and coenzyme A.
protein-phosphoribosyl dephospho-coenzyme A linkage (GO:0018247)
Namespace: biological_process
Definition: The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position.
obsolete enzyme active site formation via peptidyl cysteine sulfation (GO:0018248)
Namespace: biological_process
Definition: OBSOLETE. The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine.
Synonyms: enzyme active site formation via S-sulpho-L-cysteine
Comment: This term was obsoleted because it was created by error: cysteine sulfation is a post-translational modification, see PMID:12876326.
protein dehydration (GO:0018249)
Namespace: biological_process
Definition: The removal of a water group from a protein amino acid.
Synonyms: protein amino acid dehydration
peptidyl-tyrosine dehydrogenation (GO:0018251)
Namespace: biological_process
Definition: The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues.
Comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'.
obsolete peptide cross-linking via 5-imidazolinone glycine (GO:0018253)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde.
Synonyms: biosynthesis of protein-protein cross-link via 5-imidazolinone glycine; biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine
Comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
obsolete peptidyl-tyrosine adenylylation (GO:0018254)
Namespace: biological_process
Definition: OBSOLETE. The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine.
Synonyms: peptidyl-tyrosine adenylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete peptide cross-linking via S-glycyl-L-cysteine (GO:0018255)
Namespace: biological_process
Definition: OBSOLETE. The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins.
Comment: This term was obsoleted because it represents a molecular function.
protein formylation (GO:0018256)
Namespace: biological_process
Definition: The addition of a formyl group to a protein amino acid.
Synonyms: protein amino acid formylation
obsolete peptidyl-lysine formylation (GO:0018257)
Namespace: biological_process
Definition: OBSOLETE. The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein O-linked glycosylation via hydroxyproline (GO:0018258)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline.
Synonyms: protein amino acid O-linked glycosylation via hydroxyproline
Comment: This term was obsoleted because it did not represent a specific process. It may correspond to protein O-linked GalNAcylation; GO:0016266, protein O-linked galactosylation; GO:0180062, or protein O-linked arabinosylation; GO:0180063, all of which may be linked to a hydroxyproline in a protein.
RNA-protein covalent cross-linking via peptidyl-serine (GO:0018259)
Namespace: biological_process
Definition: The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine.
protein guanylylation (GO:0018260)
Namespace: biological_process
Definition: The addition of phospho-guanosine to a protein amino acid.
Synonyms: protein amino acid guanylylation
obsolete peptidyl-lysine guanylylation (GO:0018261)
Namespace: biological_process
Definition: OBSOLETE. The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine.
Comment: This term was obsoleted because it represents a molecular function.
isopeptide cross-linking (GO:0018262)
Namespace: biological_process
Definition: The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon.
obsolete isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine (GO:0018263)
Namespace: biological_process
Definition: OBSOLETE. The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete isopeptide cross-linking via N-(L-isoaspartyl)-glycine (GO:0018264)
Namespace: biological_process
Definition: OBSOLETE. The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine (GO:0018265)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine (GO:0018266)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine (GO:0018267)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine (GO:0018268)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine (GO:0018269)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein.
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete biotin-protein ligase activity (GO:0018271)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein.
Synonyms: biotin-apoprotein ligase activity
Comment: The reason for obsoletion is this term is an unnecessary grouping term.
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine (GO:0018272)
Namespace: biological_process
Definition: The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine.
obsolete protein-chromophore linkage via peptidyl-N6-retinal-L-lysine (GO:0018273)
Namespace: biological_process
Definition: OBSOLETE. The modification of peptidyl-lysine to form N6-retinal-L-lysine.
Comment: Term describes modified products or self-catalyzed processes.
obsolete peptide cross-linking via L-lysinoalanine (GO:0018274)
Namespace: biological_process
Definition: OBSOLETE. The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link.
Comment: This term was obsoleted because it represents a molecular function; however the enzyme responsible for this reaction has not been defined.
obsolete N-terminal peptidyl-cysteine acetylation (GO:0018275)
Namespace: biological_process
Definition: OBSOLETE. The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine.
Synonyms: peptidyl-cysteine N-acetylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete isopeptide cross-linking via N6-glycyl-L-lysine (GO:0018276)
Namespace: biological_process
Definition: OBSOLETE. The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination.
Comment: This term was obsoleted because it represents a molecular function.
protein deamination (GO:0018277)
Namespace: biological_process
Definition: The removal of an amino group from a protein amino acid.
Synonyms: protein amino acid deamination
obsolete N-terminal peptidyl-threonine deamination (GO:0018278)
Namespace: biological_process
Definition: OBSOLETE. The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid.
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein N-linked glycosylation via asparagine (GO:0018279)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.
Synonyms: protein amino acid N-linked glycosylation via asparagine
Comment: The reason for obsoletion is that this term is equivalent to protein N-linked glycosylation.
obsolete GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine (GO:0018281)
Namespace: biological_process
Definition: OBSOLETE. The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein.
Synonyms: GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine; GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine; GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine
Comment: This term was obsoleted because it represents a molecular function.
metal incorporation into metallo-sulfur cluster (GO:0018282)
Namespace: biological_process
Definition: The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide.
Synonyms: metal incorporation into metallo-sulphur cluster
iron incorporation into metallo-sulfur cluster (GO:0018283)
Namespace: biological_process
Definition: The incorporation of iron into a metallo-sulfur cluster.
Synonyms: iron incorporation into metallo-sulphur cluster
obsolete iron incorporation into protein via tetrakis-L-cysteinyl iron (GO:0018284)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein).
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide (GO:0018285)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide.
Synonyms: iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide (GO:0018287)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide.
Synonyms: iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide (GO:0018288)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide.
Synonyms: iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide
Comment: This term was obsoleted because it represents a molecular function.
molybdenum incorporation into metallo-sulfur cluster (GO:0018289)
Namespace: biological_process
Definition: The incorporation of molybdenum into a metallo-sulfur cluster.
Synonyms: molybdenum incorporation into metallo-sulphur cluster
obsolete iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide (GO:0018290)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase.
Synonyms: iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide
Comment: This term was obsoleted because it represents a molecular function.
molybdenum incorporation into iron-sulfur cluster (GO:0018291)
Namespace: biological_process
Definition: The incorporation of molybdenum into an iron-sulfur cluster.
Synonyms: molybdenum incorporation into iron-sulphur cluster
protein-FAD linkage (GO:0018293)
Namespace: biological_process
Definition: The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD).
obsolete protein-FAD linkage via S-(8alpha-FAD)-L-cysteine (GO:0018294)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine (GO:0018295)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine (GO:0018296)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine (GO:0018297)
Namespace: biological_process
Definition: OBSOLETE. The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete protein-chromophore linkage (GO:0018298)
Namespace: biological_process
Definition: OBSOLETE. The covalent or noncovalent attachment of a chromophore to a protein.
Comment: Term describes modified products or self-catalyzed processes.
obsolete iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide (GO:0018299)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide.
Synonyms: iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide (GO:0018300)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide.
Synonyms: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide; iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide
Comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist.
obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon (GO:0018301)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon.
Synonyms: iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide (GO:0018302)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide.
Synonyms: iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide (GO:0018303)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide.
Synonyms: iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide (GO:0018305)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide.
Synonyms: iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide
Comment: This term was obsoleted because it represents a molecular function.
obsolete enzyme active site formation (GO:0018307)
Namespace: biological_process
Definition: OBSOLETE. The modification of part of an enzyme to form the active site.
Comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see https://en.wikipedia.org/wiki/Active_site#Mechanisms_involved_in_Catalytic_process.