LiteFold/GO huggingface dataset:
negative regulation of neutrophil mediated killing of gram-negative bacterium (GO:0070957)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil.
Synonyms: down regulation of neutrophil mediated killing of gram-negative bacterium; down-regulation of neutrophil mediated killing of gram-negative bacterium; downregulation of neutrophil mediated killing of gram-negative bacterium; inhibition of neutrophil mediated killing of gram-negative bacterium
negative regulation of neutrophil mediated killing of gram-positive bacterium (GO:0070958)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil.
Synonyms: down regulation of neutrophil mediated killing of gram-positive bacterium; down-regulation of neutrophil mediated killing of gram-positive bacterium; downregulation of neutrophil mediated killing of gram-positive bacterium; inhibition of neutrophil mediated killing of gram-positive bacterium
negative regulation of neutrophil mediated killing of fungus (GO:0070959)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil.
Synonyms: down regulation of neutrophil mediated killing of fungus; down-regulation of neutrophil mediated killing of fungus; downregulation of neutrophil mediated killing of fungus; inhibition of neutrophil mediated killing of fungus
positive regulation of neutrophil mediated cytotoxicity (GO:0070960)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil.
Synonyms: activation of neutrophil mediated cytotoxicity; positive regulation of neutrophil mediated cell killing; stimulation of neutrophil mediated cytotoxicity; up regulation of neutrophil mediated cytotoxicity; up-regulation of neutrophil mediated cytotoxicity; upregulation of neutrophil mediated cytotoxicity
positive regulation of neutrophil mediated killing of symbiont cell (GO:0070961)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil.
Synonyms: activation of neutrophil mediated killing of symbiont cell; stimulation of neutrophil mediated killing of symbiont cell; up regulation of neutrophil mediated killing of symbiont cell; up-regulation of neutrophil mediated killing of symbiont cell; upregulation of neutrophil mediated killing of symbiont cell
positive regulation of neutrophil mediated killing of bacterium (GO:0070962)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil.
Synonyms: activation of neutrophil mediated killing of bacterium; stimulation of neutrophil mediated killing of bacterium; up regulation of neutrophil mediated killing of bacterium; up-regulation of neutrophil mediated killing of bacterium; upregulation of neutrophil mediated killing of bacterium
positive regulation of neutrophil mediated killing of gram-negative bacterium (GO:0070963)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil.
Synonyms: activation of neutrophil mediated killing of gram-negative bacterium; stimulation of neutrophil mediated killing of gram-negative bacterium; up regulation of neutrophil mediated killing of gram-negative bacterium; up-regulation of neutrophil mediated killing of gram-negative bacterium; upregulation of neutrophil mediated killing of gram-negative bacterium
positive regulation of neutrophil mediated killing of gram-positive bacterium (GO:0070964)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil.
Synonyms: activation of neutrophil mediated killing of gram-positive bacterium; stimulation of neutrophil mediated killing of gram-positive bacterium; up regulation of neutrophil mediated killing of gram-positive bacterium; up-regulation of neutrophil mediated killing of gram-positive bacterium; upregulation of neutrophil mediated killing of gram-positive bacterium
positive regulation of neutrophil mediated killing of fungus (GO:0070965)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil.
Synonyms: activation of neutrophil mediated killing of fungus; stimulation of neutrophil mediated killing of fungus; up regulation of neutrophil mediated killing of fungus; up-regulation of neutrophil mediated killing of fungus; upregulation of neutrophil mediated killing of fungus
nuclear-transcribed mRNA catabolic process, no-go decay (GO:0070966)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.
Synonyms: no-go decay; no-go mRNA decay; nuclear-transcribed mRNA breakdown, no-go decay; nuclear-transcribed mRNA catabolism, no-go decay; nuclear-transcribed mRNA degradation, no-go decay
endoplasmic reticulum exit site (GO:0070971)
Namespace: cellular_component
Definition: An endoplasmic reticulum part at which COPII-coated vesicles are produced.
Synonyms: ER exit site; transitional ER
protein localization to endoplasmic reticulum exit site (GO:0070973)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site.
Synonyms: protein localisation to endoplasmic reticulum exit site; protein localization to ER exit site
POU domain binding (GO:0070974)
Namespace: molecular_function
Definition: Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.
TIR domain binding (GO:0070976)
Namespace: molecular_function
Definition: Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.
Synonyms: Toll-Interleukin receptor domain binding
bone maturation (GO:0070977)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.
voltage-gated calcium channel complex assembly (GO:0070978)
Namespace: biological_process
Definition: Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex.
protein K11-linked ubiquitination (GO:0070979)
Namespace: biological_process
Definition: A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
L-asparagine biosynthetic process (GO:0070981)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid.
Synonyms: L-asparagine anabolism; L-asparagine biosynthesis; L-asparagine formation; L-asparagine synthesis
obsolete L-asparagine metabolic process (GO:0070982)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid.
Synonyms: L-asparagine metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
dendrite guidance (GO:0070983)
Namespace: biological_process
Definition: The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues.
Synonyms: dendritic guidance
SET domain binding (GO:0070984)
Namespace: molecular_function
Definition: Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation.
Synonyms: SET binding
transcription factor TFIIK complex (GO:0070985)
Namespace: cellular_component
Definition: A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.
Synonyms: cyclin H-CDK7 complex; Mcs6/Mcs2/Pmh1 complex; TFIIK complex
left/right axis specification (GO:0070986)
Namespace: biological_process
Definition: The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
Synonyms: left-right axis specification; left/right axis determination
error-free translesion synthesis (GO:0070987)
Namespace: biological_process
Definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
Comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
oxidative demethylation (GO:0070989)
Namespace: biological_process
Definition: The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
snRNP binding (GO:0070990)
Namespace: molecular_function
Definition: Binding to a small nuclear ribonucleoprotein particle.
medium-chain fatty acyl-CoA dehydrogenase activity (GO:0070991)
Namespace: molecular_function
Definition: Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
Synonyms: MCAD activity
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
translation initiation complex (GO:0070992)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
cytosolic translation preinitiation complex (GO:0070993)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA.
detection of oxidative stress (GO:0070994)
Namespace: biological_process
Definition: The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.
obsolete NADPH oxidation (GO:0070995)
Namespace: biological_process
Definition: OBSOLETE. A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP+.
Synonyms: NADP (reduced) dehydrogenation; NADP (reduced) oxidation; NADPH dehydrogenation; reduced NADP dehydrogenation; reduced NADP oxidation; reduced nicotinamide adenine dinucleotide phosphate dehydrogenation; reduced nicotinamide adenine dinucleotide phosphate oxidation
Comment: This term was obsoleted because it represents a reactant in oxidoreductase reactions.
type 1 melanocortin receptor binding (GO:0070996)
Namespace: molecular_function
Definition: Binding to a type 1 melanocortin receptor.
Synonyms: type 1 melanocortin receptor ligand
obsolete neuron death (GO:0070997)
Namespace: biological_process
Definition: OBSOLETE. The process of cell death in a neuron.
Synonyms: neuron cell death; neuronal cell death
Comment: The reason for obsoletion is that this term often represents an assay, or a phenotype and not a GO process.
obsolete detection of mechanical stimulus involved in sensory perception of gravity (GO:0070999)
Namespace: biological_process
Definition: OBSOLETE. The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
response to magnetism (GO:0071000)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus.
Synonyms: response to magnetic stimulus
U4/U6 snRNP (GO:0071001)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes.
U4atac/U6atac snRNP (GO:0071002)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes.
penta-snRNP complex (GO:0071003)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that is formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins.
Synonyms: penta-RNP complex
U2-type prespliceosome (GO:0071004)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
Synonyms: GT-AG prespliceosome; major prespliceosome; mammalian U2-type spliceosomal complex A; yeast U2-type spliceosomal complex B
U2-type precatalytic spliceosome (GO:0071005)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
Synonyms: GT-AG precatalytic spliceosome; major precatalytic spliceosome; mammalian U2-type spliceosomal complex B; mammalian U2-type spliceosomal complex B1; yeast U12-type spliceosomal complex A2-1
U2-type catalytic step 1 spliceosome (GO:0071006)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.
Synonyms: GT-AG catalytic step 1 spliceosome; major catalytic step 1 spliceosome; mammalian U2-type spliceosomal complex B*; mammalian U2-type spliceosomal complex B2; U2-type activated spliceosome; yeast U2-type spliceosomal complex A1
U2-type post-mRNA release spliceosomal complex (GO:0071008)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs.
Synonyms: GT-AG post-mRNA release spliceosomal complex; major post-mRNA release spliceosomal complex; mammalian U2-type spliceosomal complex I; U2/U5/U6 snRNP complex; U2/U5/U6 tri-snRNP complex
U4atac/U6atac x U5 tri-snRNP complex (GO:0071009)
Namespace: cellular_component
Definition: A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs.
Synonyms: U4atac/U6atac.U5 snRNP complex
prespliceosome (GO:0071010)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex.
Synonyms: mammalian spliceosomal complex A; prespliceosomal complex; yeast spliceosomal complex B
precatalytic spliceosome (GO:0071011)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
Synonyms: mammalian spliceosomal complex B; mammalian spliceosomal complex B1; yeast spliceosomal complex A2-1
catalytic step 1 spliceosome (GO:0071012)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
Synonyms: activated spliceosome; mammalian spliceosomal complex B*; mammalian spliceosomal complex B2; yeast spliceosomal complex A1
catalytic step 2 spliceosome (GO:0071013)
Namespace: cellular_component
Definition: A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
Synonyms: mammalian spliceosomal complex C; mammalian spliceosomal complex C1; yeast spliceosomal complex A2-2
post-mRNA release spliceosomal complex (GO:0071014)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac.
Synonyms: mammalian spliceosomal complex I
U12-type prespliceosome (GO:0071015)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
Synonyms: AT-AC prespliceosome; mammalian U12-type spliceosomal complex A; minor prespliceosome; yeast U12-type spliceosomal complex B
U12-type precatalytic spliceosome (GO:0071016)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs.
Synonyms: AT-AC precatalytic spliceosome; mammalian U12-type spliceosomal complex B; mammalian U12-type spliceosomal complex B1; minor precatalytic spliceosome; yeast U12-type spliceosomal complex A2-1
U12-type catalytic step 1 spliceosome (GO:0071017)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs.
Synonyms: AT-AC catalytic step 1 spliceosome; mammalian U12-type spliceosomal complex B*; mammalian U12-type spliceosomal complex B2; minor catalytic step 1 spliceosome; U12-type activated spliceosome; yeast U12-type spliceosomal complex A1
U12-type catalytic step 2 spliceosome (GO:0071018)
Namespace: cellular_component
Definition: A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs.
Synonyms: AT-AC catalytic step 2 spliceosome; mammalian U12-type spliceosomal complex C; mammalian U12-type spliceosomal complex C1; minor catalytic step 2 spliceosome; yeast U12-type spliceosomal complex A2-2
U12-type post-mRNA release spliceosomal complex (GO:0071019)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs.
Synonyms: AT-AC post-mRNA release spliceosomal complex; mammalian U12-type spliceosomal complex I; minor post-mRNA release spliceosomal complex
post-spliceosomal complex (GO:0071020)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5.
Synonyms: mammalian spliceosomal complex C2; yeast spliceosomal complex A2-3
U12-type post-spliceosomal complex (GO:0071022)
Namespace: cellular_component
Definition: A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac.
Synonyms: AT-AC post-spliceosomal complex; mammalian U12-type spliceosomal complex C2; minor post-spliceosomal complex; yeast U12-type spliceosomal complex A2-3
SL snRNP (GO:0071024)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins.