LiteFold/GO huggingface dataset:
neuron projection cytoplasm (GO:0120111)
Namespace: cellular_component
Definition: All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.
UDP-glucose transmembrane transport into endoplasmic reticulum (GO:0120112)
Namespace: biological_process
Definition: The directed movement of UDP-glucose from cytosol to endoplasmic reticulum.
Sm-like protein family complex (GO:0120114)
Namespace: cellular_component
Definition: A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.
glucagon processing (GO:0120116)
Namespace: biological_process
Definition: The formation of mature glucagon by proteolysis of the precursor proglucagon.
T cell meandering migration (GO:0120117)
Namespace: biological_process
Definition: The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs).
Synonyms: lymph node surveillance; T cell meandering search
flagella connector (GO:0120118)
Namespace: cellular_component
Definition: A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum.
Comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use.
flagellum attachment zone (GO:0120119)
Namespace: cellular_component
Definition: A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species.
Synonyms: FAZ
Comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use.
bilobe structure (GO:0120120)
Namespace: cellular_component
Definition: A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone).
Synonyms: kinetoplastid flagellar hook complex
Comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use.
tripartite attachment complex (GO:0120121)
Namespace: cellular_component
Definition: A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body.
Synonyms: TAC
prolactin metabolic process (GO:0120122)
Namespace: biological_process
Definition: The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals.
Synonyms: prolactin metabolism
ubiquitin activating enzyme complex (GO:0120123)
Namespace: cellular_component
Definition: A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
Synonyms: E1 complex; E1 ubiquitin-activating enzyme
membrane fusion priming complex (GO:0120124)
Namespace: cellular_component
Definition: A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes.
Synonyms: GATE-16 complex; LMA1 complex
response to copper ion starvation (GO:0120126)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion.
response to zinc ion starvation (GO:0120127)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion.
positive regulation of apoptotic process in bone marrow cell (GO:0120132)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow.
Synonyms: activation of apoptosis in bone marrow; positive regulation of apoptosis in bone marrow; positive regulation of apoptotic process in bone marrow; positive regulation of bone marrow cell apoptosis; positive regulation of bone marrow cell programmed cell death by apoptosis; positive regulation of killing of bone marrow cells; positive regulation of programmed cell death of bone marrow cells by apoptosis; positive regulation of programmed cell death, bone marrow cells; up regulation of apoptosis in bone marrow; up-regulation of apoptosis in bone marrow; upregulation of apoptosis in bone marrow
negative regulation of actin cortical patch assembly (GO:0120133)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches.
Synonyms: down regulation of actin cortical patch assembly; down-regulation of actin cortical patch assembly; downregulation of actin cortical patch assembly; inhibition of actin cortical patch assembly
proximal portion of axoneme (GO:0120134)
Namespace: cellular_component
Definition: The portion of the axoneme that is close to the base of the cilium.
Synonyms: proximal part of axoneme
distal portion of axoneme (GO:0120135)
Namespace: cellular_component
Definition: The portion of the axoneme that is close to the tip of the cilium.
Synonyms: distal part of axoneme
dUMP kinase activity (GO:0120136)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + dUMP = ADP + dUDP.
Synonyms: ATP:dUMP phosphotransferase activity; deoxyuridine monophosphate kinase activity; dUMP-kinase activity
obsolete positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity (GO:0120137)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0120138)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0120139)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0120140)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.
Comment: This term was obsoleted because it represents a molecular function.
regulation of ecdysone receptor signaling pathway (GO:0120141)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor signaling pathway.
Synonyms: regulation of ecdysone receptor-mediated signaling pathway
positive regulation of ecdysone receptor signaling pathway (GO:0120142)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of any ecdysone receptor signaling pathway.
Synonyms: positive regulation of ecdysone receptor-mediated signaling pathway
negative regulation of ecdysone receptor signaling pathway (GO:0120143)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor signaling pathway.
Synonyms: negative regulation of ecdysone receptor-mediated signaling pathway
protein localization to basal ectoplasmic specialization (GO:0120145)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization.
Synonyms: protein localisation in basal ectoplasmic specialization; protein localisation to basal ectoplasmic specialization; protein localization in basal ectoplasmic specialization
sulfatide binding (GO:0120146)
Namespace: molecular_function
Definition: Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group.
Synonyms: 3-O-sulfogalactosylceramide binding; SM4 binding; sulfated galactocerebroside binding
formylglycine-generating oxidase activity (GO:0120147)
Namespace: molecular_function
Definition: Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.
host cell centrosome (GO:0120148)
Namespace: cellular_component
Definition: A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
Synonyms: host centrosome
host cell peroxisome (GO:0120149)
Namespace: cellular_component
Definition: A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
Synonyms: host peroxisome
obsolete positive regulation of mitotic actomyosin contractile ring disassembly (GO:0120151)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring disassembly.
Comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using another term
calcium-dependent carbohydrate binding (GO:0120153)
Namespace: molecular_function
Definition: Binding to a carbohydrate in the presence of calcium.
negative regulation of ERBB4 signaling pathway (GO:0120154)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway.
MIH complex (GO:0120155)
Namespace: cellular_component
Definition: A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins.
Synonyms: Mlc1p-Iqg1p-Hof1p complex
PAR polarity complex (GO:0120157)
Namespace: cellular_component
Definition: A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC.
Synonyms: apical polarity complex; BEM1-CDC24-CLA4 complex; Cdc42p GEF-PAK complex; PAR3-PAR6-atypical PKC; PAR3/PAR6/aPKC; PAR6-PAR3-aPKC complex
Comment: "This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.
positive regulation of collagen catabolic process (GO:0120158)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.
Synonyms: activation of collagen catabolic process; positive regulation of collagen breakdown; positive regulation of collagen catabolism; positive regulation of collagen degradation; up regulation of collagen catabolic process; up-regulation of collagen catabolic process; upregulation of collagen catabolic process
rRNA pseudouridine synthase activity (GO:0120159)
Namespace: molecular_function
Definition: Catalysis of the reaction: a uridine in rRNA = a pseudouridine in rRNA. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
intraciliary transport particle A binding (GO:0120160)
Namespace: molecular_function
Definition: Binding to an intraciliary transport particle A (IFT A) complex.
Synonyms: IFT A complex binding; intraciliary transport complex A binding; intraflagellar transport complex A binding; intraflagellar transport particle A binding
regulation of cold-induced thermogenesis (GO:0120161)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of cold-induced thermogenesis.
Synonyms: regulation of CIT
positive regulation of cold-induced thermogenesis (GO:0120162)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
Synonyms: positive regulation of CIT
negative regulation of cold-induced thermogenesis (GO:0120163)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
Synonyms: negative regulation of CIT
conidium germination (GO:0120164)
Namespace: biological_process
Definition: The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination.
protoperithecium formation (GO:0120166)
Namespace: biological_process
Definition: The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium.
Comment: Note that this term represents protoperithecium formation across homothallic and heterothallic species that do not have the same mechanism.
detection of hot stimulus involved in thermoception (GO:0120168)
Namespace: biological_process
Definition: The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception.
Synonyms: sensory detection of heat stimulus during thermoception; sensory detection of hot stimulus during thermoception; sensory transduction of heat stimulus during thermoception; sensory transduction of hot stimulus during thermoception; thermoception, sensory detection of heat stimulus; thermoception, sensory detection of hot stimulus; thermoception, sensory transduction of heat stimulus; thermoception, sensory transduction of hot stimulus
detection of cold stimulus involved in thermoception (GO:0120169)
Namespace: biological_process
Definition: The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception.
Synonyms: sensory detection of cold stimulus during thermoception; sensory transduction of cold stimulus during thermoception; thermoception, sensory detection of cold stimulus; thermoception, sensory transduction of cold stimulus
intraciliary transport particle B binding (GO:0120170)
Namespace: molecular_function
Definition: Binding to an intraciliary transport particle B (IFT B) complex.
Synonyms: IFT B complex binding; intraciliary transport complex B binding; intraflagellar transport complex B binding; intraflagellar transport particle B binding
Cdc24p-Far1p-Gbetagamma complex (GO:0120171)
Namespace: cellular_component
Definition: A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit).
Synonyms: CDC24-FAR1-BG complex; CDC24-FAR1-Gbetagamma complex; Cdc24p-Far1p-BG complex
stress-induced homeostatically regulated protein degradation pathway (GO:0120174)
Namespace: biological_process
Definition: A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway.
Synonyms: SHRED pathway
Comment: Note, although the SHRED pathway may contain some components in common with ER-associated protein degradation (ERAD) pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10 do not appear to be involved, and as such these pathways are currently considered to be distinct. ERAD pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M) and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by subsequent substrate ubiquitination and proteosome-mediated degradation. In contrast the SHRED pathway, although inducible by stress, targets diverse ER membrane and cytosolic proteins as well as numerous other native proteins in the absence of stress. In the SHRED pathway an Nma111p serine protease-mediated cleavage results in the generation of a Roq1p fragment that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. SHRED is also considered to be distinct from the endoplasmic reticulum unfolded protein response (GO:0030968), a process by which ER stress activates the ER membrane protein Ire1p, resulting in splicing of the HAC1 mRNA, followed by Hac1p-mediated up-regulation of UPR genes. Induction of SHRED does not require IRE1 or HAC1, and as such is currently considered to be distinct.
regulation of torso signaling pathway (GO:0120175)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the torso signaling pathway.
positive regulation of torso signaling pathway (GO:0120176)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the torso signaling pathway.
negative regulation of torso signaling pathway (GO:0120177)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway.
steroid hormone biosynthetic process (GO:0120178)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
adherens junction disassembly (GO:0120179)
Namespace: biological_process
Definition: The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
focal adhesion disassembly (GO:0120181)
Namespace: biological_process
Definition: The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity.
regulation of focal adhesion disassembly (GO:0120182)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.
negative regulation of focal adhesion disassembly (GO:0120184)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components.
negative regulation of protein localization to chromatin (GO:0120186)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.
Synonyms: negative regulation of protein localisation to chromatin
regulation of bile acid secretion (GO:0120188)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
negative regulation of bile acid secretion (GO:0120190)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.