LiteFold/GO huggingface dataset:
positive regulation of superoxide anion generation (GO:0032930)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
Synonyms: activation of superoxide release; positive regulation of superoxide release; stimulation of superoxide release; up regulation of superoxide release; up-regulation of superoxide release; upregulation of superoxide release
histone H3K56 acetyltransferase activity (GO:0032931)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56).
Synonyms: histone acetylase activity (H3-K56 specific); histone acetyltransferase activity (H3-K56 specific); histone H3-K56 acetyltransferase activity; histone lysine N-acetyltransferase activity (H3-K56 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
negative regulation of astral microtubule depolymerization (GO:0032932)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules.
Synonyms: astral microtubule stabilization
SREBP signaling pathway (GO:0032933)
Namespace: biological_process
Definition: The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
Synonyms: activation of sterol regulatory element binding protein target gene transcription; endoplasmic reticulum to nucleus sterol response pathway; endoplasmic reticulum-nuclear sterol response pathway; ER to nucleus sterol response pathway; ER-nuclear sterol response pathway; positive regulation of sterol regulatory element binding protein target gene transcription; positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response; positive regulation of transcription via sterol regulatory element binding; positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; SREBP signalling; SREBP target gene transcriptional activation; SREBP-mediated signaling pathway; SREBP-mediated signalling pathway; sterol depletion response, SREBP target gene transcriptional activation; sterol regulatory element binding protein target gene transcriptional activation; sterol response element binding protein signaling pathway; stimulation of sterol regulatory element binding protein target gene transcription; up regulation of sterol regulatory element binding protein target gene transcription; up-regulation of sterol regulatory element binding protein target gene transcription; upregulation of sterol regulatory element binding protein target gene transcription
sterol binding (GO:0032934)
Namespace: molecular_function
Definition: Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
Synonyms: sterol carrier activity
sterol sensor activity (GO:0032935)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol.
Synonyms: sterol sensing activity; sterol-sensing domain
SREBP-SCAP complex (GO:0032936)
Namespace: cellular_component
Definition: A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.
Synonyms: Sre1-Scp1 complex
SREBP-SCAP-Insig complex (GO:0032937)
Namespace: cellular_component
Definition: A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane.
negative regulation of translation in response to oxidative stress (GO:0032938)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
positive regulation of translation in response to oxidative stress (GO:0032939)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
Synonyms: activation of translation in response to oxidative stress; stimulation of translation in response to oxidative stress; up regulation of translation in response to oxidative stress; up-regulation of translation in response to oxidative stress; upregulation of translation in response to oxidative stress
secretion by tissue (GO:0032941)
Namespace: biological_process
Definition: The controlled release of a substance by a tissue.
Synonyms: expulsion of gland contents; tissue secretion
inositol-1,4,5,6-tetrakisphosphate 2-kinase activity (GO:0032942)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + ADP + H+.
Synonyms: 1D-myo-inositol-tetrakisphosphate 2-kinase activity; inositol tetrakisphosphate 2-kinase activity; inositol-tetrakisphosphate 2-kinase activity
mononuclear cell proliferation (GO:0032943)
Namespace: biological_process
Definition: The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.
Synonyms: PBMC proliferation; peripheral blood mononuclear cell proliferation
regulation of mononuclear cell proliferation (GO:0032944)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.
Synonyms: regulation of PBMC proliferation; regulation of peripheral blood mononuclear cell proliferation
negative regulation of mononuclear cell proliferation (GO:0032945)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.
Synonyms: negative regulation of PBMC proliferation; negative regulation of peripheral blood mononuclear cell proliferation
positive regulation of mononuclear cell proliferation (GO:0032946)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.
Synonyms: activation of mononuclear cell proliferation; positive regulation of PBMC proliferation; positive regulation of peripheral blood mononuclear cell proliferation; stimulation of mononuclear cell proliferation; up regulation of mononuclear cell proliferation; up-regulation of mononuclear cell proliferation; upregulation of mononuclear cell proliferation
regulation of alpha-glucan metabolic process (GO:0032948)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans.
Synonyms: regulation of alpha-glucan metabolism
regulation of alpha-glucan biosynthetic process (GO:0032949)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans.
Synonyms: regulation of alpha-glucan anabolism; regulation of alpha-glucan biosynthesis; regulation of alpha-glucan formation; regulation of alpha-glucan synthesis
regulation of beta-glucan metabolic process (GO:0032950)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans.
Synonyms: regulation of beta-glucan metabolism
obsolete regulation of (1->3)-beta-D-glucan metabolic process (GO:0032952)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans.
Synonyms: regulation of (1->3)-beta-D-glucan metabolism; regulation of 1,3-beta-D-glucan metabolic process; regulation of 1,3-beta-glucan metabolic process; regulation of 1,3-beta-glucan metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
regulation of (1->3)-beta-D-glucan biosynthetic process (GO:0032953)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans.
Synonyms: regulation of 1,3-beta-glucan anabolism; regulation of 1,3-beta-glucan biosynthesis; regulation of 1,3-beta-glucan biosynthetic process; regulation of 1,3-beta-glucan formation; regulation of 1,3-beta-glucan synthesis
regulation of cytokinetic process (GO:0032954)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of a cytokinetic process.
regulation of division septum assembly (GO:0032955)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
Synonyms: regulation of division septum formation
regulation of actin cytoskeleton organization (GO:0032956)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
Synonyms: regulation of actin cytoskeleton organisation; regulation of actin cytoskeleton organization and biogenesis
inositol phosphate biosynthetic process (GO:0032958)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
Synonyms: inositol phosphate anabolism; inositol phosphate biosynthesis; inositol phosphate formation; inositol phosphate synthesis; myo-inositol phosphate biosynthetic process
inositol trisphosphate biosynthetic process (GO:0032959)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
Synonyms: inositol trisphosphate anabolism; inositol trisphosphate biosynthesis; inositol trisphosphate formation; inositol trisphosphate synthesis; IP3 biosynthesis; IP3 biosynthetic process; myo-inositol trisphosphate biosynthetic process
regulation of inositol trisphosphate biosynthetic process (GO:0032960)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
Synonyms: regulation of inositol trisphosphate anabolism; regulation of inositol trisphosphate biosynthesis; regulation of inositol trisphosphate formation; regulation of inositol trisphosphate synthesis; regulation of IP3 biosynthesis; regulation of IP3 biosynthetic process; regulation of myo-inositol trisphosphate biosynthesis; regulation of myo-inositol trisphosphate biosynthetic process
negative regulation of inositol trisphosphate biosynthetic process (GO:0032961)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
Synonyms: negative regulation of inositol trisphosphate anabolism; negative regulation of inositol trisphosphate biosynthesis; negative regulation of inositol trisphosphate formation; negative regulation of inositol trisphosphate synthesis; negative regulation of IP3 biosynthesis; negative regulation of IP3 biosynthetic process; negative regulation of myo-inositol trisphosphate biosynthesis; negative regulation of myo-inositol trisphosphate biosynthetic process
positive regulation of inositol trisphosphate biosynthetic process (GO:0032962)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.
Synonyms: positive regulation of inositol trisphosphate anabolism; positive regulation of inositol trisphosphate biosynthesis; positive regulation of inositol trisphosphate formation; positive regulation of inositol trisphosphate synthesis; positive regulation of IP3 biosynthesis; positive regulation of IP3 biosynthetic process; positive regulation of myo-inositol trisphosphate biosynthesis; positive regulation of myo-inositol trisphosphate biosynthetic process
collagen biosynthetic process (GO:0032964)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
Synonyms: collagen anabolism; collagen biosynthesis; collagen formation; collagen synthesis
regulation of collagen biosynthetic process (GO:0032965)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
Synonyms: regulation of collagen anabolism; regulation of collagen biosynthesis; regulation of collagen formation; regulation of collagen synthesis
negative regulation of collagen biosynthetic process (GO:0032966)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
Synonyms: negative regulation of collagen anabolism; negative regulation of collagen biosynthesis; negative regulation of collagen formation; negative regulation of collagen synthesis
positive regulation of transcription elongation by RNA polymerase II (GO:0032968)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
Synonyms: positive regulation of gene-specific transcription elongation from RNA polymerase II promoter; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription elongation from RNA polymerase II promoter
endosomal scaffold complex (GO:0032969)
Namespace: cellular_component
Definition: A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling.
Synonyms: endosomal adaptor complex; MP1-p14 scaffolding complex
regulation of muscle filament sliding (GO:0032971)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of muscle filament sliding.
regulation of muscle filament sliding speed (GO:0032972)
Namespace: biological_process
Definition: Any process that modulates the velocity of muscle filament sliding.
amino acid transmembrane export from vacuole (GO:0032974)
Namespace: biological_process
Definition: The directed movement of amino acids out of the vacuole, across the vacuolar membrane.
Synonyms: amino acid efflux from vacuole; vacuolar amino acid export
release of matrix enzymes from mitochondria (GO:0032976)
Namespace: biological_process
Definition: The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process.
Synonyms: mAST release from mitochondria; release of aspartate aminotransferase from mitochondria
Comment: Annotation to this term should be done with caution, particularly if the mechanism is not well clarified.
membrane insertase activity (GO:0032977)
Namespace: molecular_function
Definition: Binds transmembrane domain-containing proteins and mediates their integration into a membrane.
obsolete protein insertion into membrane from inner side (GO:0032978)
Namespace: biological_process
Definition: OBSOLETE. The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side.
Synonyms: insertion of proteins into membrane from the inner side
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
protein insertion into mitochondrial inner membrane from matrix (GO:0032979)
Namespace: biological_process
Definition: The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.
Synonyms: insertion of proteins into the mitochondrial membrane from the inner side; protein insertion into mitochondrial inner membrane from matrix side; protein insertion into mitochondrial membrane from inner side
keratinocyte activation (GO:0032980)
Namespace: biological_process
Definition: A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines.
mitochondrial respiratory chain complex I assembly (GO:0032981)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
Synonyms: mitochondrial complex I assembly; mitochondrial NADH dehydrogenase complex (ubiquinone) assembly
kainate selective glutamate receptor complex (GO:0032983)
Namespace: cellular_component
Definition: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits.
protein-containing complex disassembly (GO:0032984)
Namespace: biological_process
Definition: The disaggregation of a protein-containing macromolecular complex into its constituent components.
Synonyms: cellular macromolecule complex disassembly; cellular protein complex disassembly; macromolecule complex disassembly; protein complex disassembly
protein-carbohydrate complex disassembly (GO:0032985)
Namespace: biological_process
Definition: The disaggregation of a protein-carbohydrate complex into its constituent components.
protein-DNA complex disassembly (GO:0032986)
Namespace: biological_process
Definition: The disaggregation of a protein-DNA complex into its constituent components.
Synonyms: DNA-protein complex disassembly
cellular anatomical entity morphogenesis (GO:0032989)
Namespace: biological_process
Definition: The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.
Synonyms: cellular component morphogenesis; cellular structure morphogenesis
obsolete cell part morphogenesis (GO:0032990)
Namespace: biological_process
Definition: OBSOLETE. The process in which the anatomical structures of a cell part are generated and organized.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
protein-containing complex (GO:0032991)
Namespace: cellular_component
Definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
Synonyms: macromolecular complex; macromolecule complex; protein complex; protein containing complex; protein-protein complex
Comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
protein-carbohydrate complex (GO:0032992)
Namespace: cellular_component
Definition: A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other.
Comment: Macromolecular complexes in which the carbohydrate component is all covalently bound to protein are not considered protein carbohydrate complexes.
protein-lipid complex (GO:0032994)
Namespace: cellular_component
Definition: A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other.
Comment: Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes.