LiteFold/GO huggingface dataset:
positive regulation of calcium-independent cell-cell adhesion (GO:0051041)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion.
Synonyms: activation of calcium-independent cell-cell adhesion; stimulation of calcium-independent cell-cell adhesion; up regulation of calcium-independent cell-cell adhesion; up-regulation of calcium-independent cell-cell adhesion; upregulation of calcium-independent cell-cell adhesion
negative regulation of calcium-independent cell-cell adhesion (GO:0051042)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion.
Synonyms: down regulation of calcium-independent cell-cell adhesion; down-regulation of calcium-independent cell-cell adhesion; downregulation of calcium-independent cell-cell adhesion; inhibition of calcium-independent cell-cell adhesion
regulation of membrane protein ectodomain proteolysis (GO:0051043)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
positive regulation of membrane protein ectodomain proteolysis (GO:0051044)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
Synonyms: activation of membrane protein ectodomain proteolysis; stimulation of membrane protein ectodomain proteolysis; up regulation of membrane protein ectodomain proteolysis; up-regulation of membrane protein ectodomain proteolysis; upregulation of membrane protein ectodomain proteolysis
negative regulation of membrane protein ectodomain proteolysis (GO:0051045)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
Synonyms: down regulation of membrane protein ectodomain proteolysis; down-regulation of membrane protein ectodomain proteolysis; downregulation of membrane protein ectodomain proteolysis; inhibition of membrane protein ectodomain proteolysis
regulation of secretion (GO:0051046)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
positive regulation of secretion (GO:0051047)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
Synonyms: activation of secretion; stimulation of secretion; up regulation of secretion; up-regulation of secretion; upregulation of secretion
negative regulation of secretion (GO:0051048)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
Synonyms: down regulation of secretion; down-regulation of secretion; downregulation of secretion; inhibition of secretion
regulation of transport (GO:0051049)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of transport (GO:0051050)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of transport; stimulation of transport; up regulation of transport; up-regulation of transport; upregulation of transport
negative regulation of transport (GO:0051051)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of transport; down-regulation of transport; downregulation of transport; inhibition of transport
regulation of DNA metabolic process (GO:0051052)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.
Synonyms: regulation of DNA metabolism
negative regulation of DNA metabolic process (GO:0051053)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.
Synonyms: down regulation of DNA metabolic process; down-regulation of DNA metabolic process; downregulation of DNA metabolic process; inhibition of DNA metabolic process; negative regulation of DNA metabolism
positive regulation of DNA metabolic process (GO:0051054)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.
Synonyms: activation of DNA metabolic process; positive regulation of DNA metabolism; stimulation of DNA metabolic process; up regulation of DNA metabolic process; up-regulation of DNA metabolic process; upregulation of DNA metabolic process
negative regulation of lipid biosynthetic process (GO:0051055)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
Synonyms: down regulation of lipid biosynthetic process; down-regulation of lipid biosynthetic process; downregulation of lipid biosynthetic process; inhibition of lipid biosynthetic process; negative regulation of lipid anabolism; negative regulation of lipid biosynthesis; negative regulation of lipid formation; negative regulation of lipid synthesis; negative regulation of lipogenesis
regulation of small GTPase mediated signal transduction (GO:0051056)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
Synonyms: regulation of small GTPase-mediated signal transduction
positive regulation of small GTPase mediated signal transduction (GO:0051057)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
Synonyms: activation of small GTPase mediated signal transduction; positive regulation of small GTPase-mediated signal transduction; stimulation of small GTPase mediated signal transduction; up regulation of small GTPase mediated signal transduction; up-regulation of small GTPase mediated signal transduction; upregulation of small GTPase mediated signal transduction
negative regulation of small GTPase mediated signal transduction (GO:0051058)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.
Synonyms: down regulation of small GTPase mediated signal transduction; down-regulation of small GTPase mediated signal transduction; downregulation of small GTPase mediated signal transduction; inhibition of small GTPase mediated signal transduction; negative regulation of small GTPase-mediated signal transduction
NF-kappaB binding (GO:0051059)
Namespace: molecular_function
Definition: Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
pullulanase activity (GO:0051060)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen.
Synonyms: alpha-dextrin endo-1,6-alpha-glucosidase activity; amylopectin 6-glucanohydrolase activity; bacterial debranching enzyme; debranching enzyme activity; limit dextrinase; pullulan 6-glucanohydrolase activity; pullulan alpha-1,6-glucanohydrolase activity; R-enzyme
ADP reductase activity (GO:0051061)
Namespace: molecular_function
Definition: Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin.
Synonyms: ADP reduction
UDP reductase activity (GO:0051062)
Namespace: molecular_function
Definition: Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin.
Synonyms: UDP reduction
CDP reductase activity (GO:0051063)
Namespace: molecular_function
Definition: Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin.
Synonyms: CDP reduction
obsolete TTP reductase activity (GO:0051064)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
Synonyms: TTP reduction
Comment: The reason for obsoletion is that this term is more specific than the specificity of any known gene product.
obsolete CTP reductase activity (GO:0051065)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
Synonyms: CTP reduction
Comment: The reason for obsoletion is that this term is more specific than the specificity of any known gene product.
dihydrobiopterin metabolic process (GO:0051066)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions.
Synonyms: 6,7-dihydrobiopterin metabolic process; 7,8-dihydrobiopterin metabolic process; dihydrobiopterin reduction; dihydropterin metabolic process; dihydropterin metabolism
dihydropteridine metabolic process (GO:0051067)
Namespace: biological_process
Definition: The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4.
Synonyms: 6,7-dihydropteridine metabolic process; dihydropteridine metabolism; dihydropteridine reduction
dihydrolipoamide metabolic process (GO:0051068)
Namespace: biological_process
Definition: The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor.
Synonyms: dihydrolipoamide metabolism; dihydrolipoamide reduction; dihydrothioctamide metabolic process; dihydrothioctamide metabolism
galactomannan metabolic process (GO:0051069)
Namespace: biological_process
Definition: The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units.
Synonyms: galactomannan metabolism
obsolete 4,6-pyruvylated galactose residue metabolic process (GO:0051071)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain.
Synonyms: 4,6-pyruvylated galactose residue metabolism; 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process; 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism; PvGal metabolic process; PvGal metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
4,6-pyruvylated galactose residue biosynthetic process (GO:0051072)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain.
Synonyms: 4,6-pyruvylated galactose residue anabolism; 4,6-pyruvylated galactose residue biosynthesis; 4,6-pyruvylated galactose residue formation; 4,6-pyruvylated galactose residue synthesis; 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis; 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process; PvGal biosynthesis; PvGal biosynthetic process
adenosylcobinamide-GDP ribazoletransferase activity (GO:0051073)
Namespace: molecular_function
Definition: Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin.
Synonyms: adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity; cobalamin (5'-phosphate) synthase activity; cobalamin synthase activity; cobalamin-5'-phosphate synthase activity; CobS
obsolete protein tetramerization activity (GO:0051074)
Namespace: molecular_function
Definition: OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
Synonyms: protein tetramerization activity
Comment: This term was made obsolete because it represents a process.
S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity (GO:0051075)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA.
Synonyms: S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity
secondary cell septum (GO:0051077)
Namespace: cellular_component
Definition: Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum.
Synonyms: secondary septum
meiotic nuclear membrane disassembly (GO:0051078)
Namespace: biological_process
Definition: The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs.
Synonyms: meiotic nuclear envelope breakdown; meiotic nuclear envelope catabolism; meiotic nuclear envelope degradation; meiotic nuclear envelope disassembly
meiosis I nuclear membrane disassembly (GO:0051079)
Namespace: biological_process
Definition: The controlled breakdown of the nuclear membranes during the first division of meiosis.
Synonyms: meiosis I nuclear envelope breakdown; meiosis I nuclear envelope catabolism; meiosis I nuclear envelope degradation; meiosis I nuclear envelope disassembly
meiosis II nuclear membrane disassembly (GO:0051080)
Namespace: biological_process
Definition: The controlled breakdown of the nuclear membranes during the second division of meiosis.
Synonyms: meiosis II nuclear envelope breakdown; meiosis II nuclear envelope catabolism; meiosis II nuclear envelope degradation; meiosis II nuclear envelope disassembly
nuclear membrane disassembly (GO:0051081)
Namespace: biological_process
Definition: The controlled breakdown of the nuclear membranes, for example during cellular division.
Synonyms: nuclear envelope breakdown; nuclear envelope catabolism; nuclear envelope degradation; nuclear envelope disassembly
unfolded protein binding (GO:0051082)
Namespace: molecular_function
Definition: Binding to an unfolded protein.
Synonyms: chaperone activity
'de novo' post-translational protein folding (GO:0051084)
Namespace: biological_process
Definition: The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis.
Synonyms: 'de novo' posttranslational protein folding
obsolete chaperone cofactor-dependent protein refolding (GO:0051085)
Namespace: biological_process
Definition: OBSOLETE. The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
Synonyms: chaperone co-factor-dependent protein folding; chaperone co-factor-dependent protein refolding; chaperone cofactor-dependent 'de novo' protein folding; chaperone cofactor-dependent protein folding; chaperone mediated protein folding requiring cofactor
Comment: This term represent a GO-CAM model
obsolete chaperone mediated protein folding independent of cofactor (GO:0051086)
Namespace: biological_process
Definition: OBSOLETE. The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release.
Synonyms: chaperone cofactor-independent protein folding
Comment: This term represent a GO-CAM model
protein-folding chaperone binding (GO:0051087)
Namespace: molecular_function
Definition: Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
Synonyms: chaperone binding; chaperone protein binding; co-chaperone activity; co-chaperonin activity
obsolete PMA-inducible membrane protein ectodomain proteolysis (GO:0051088)
Namespace: biological_process
Definition: OBSOLETE. The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.
Comment: This term was obsoleted because it represents an assay to induce PKC.
constitutive protein ectodomain proteolysis (GO:0051089)
Namespace: biological_process
Definition: The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands.
obsolete regulation of DNA-binding transcription factor activity (GO:0051090)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms: regulation of androgen receptor activity; regulation of DNA binding transcription factor activity; regulation of sequence-specific DNA binding transcription factor activity; regulation of thyroid hormone receptor activity; regulation of transcription factor activity
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete positive regulation of DNA-binding transcription factor activity (GO:0051091)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms: activation of transcription factor activity; positive regulation of DNA binding transcription factor activity; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of thyroid hormone receptor activity; positive regulation of transcription factor activity; stimulation of transcription factor activity; up regulation of transcription factor activity; up-regulation of transcription factor activity; upregulation of transcription factor activity
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete positive regulation of NF-kappaB transcription factor activity (GO:0051092)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
Synonyms: activation of NF-kappaB; activation of NF-kappaB transcription factor; NF-kappaB activation
Comment: The reason for obsoletion is that this term represents a molecular function.
negative regulation of developmental process (GO:0051093)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Synonyms: down regulation of developmental process; down-regulation of developmental process; downregulation of developmental process; inhibition of developmental process
positive regulation of developmental process (GO:0051094)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Synonyms: activation of developmental process; stimulation of developmental process; up regulation of developmental process; up-regulation of developmental process; upregulation of developmental process
positive regulation of helicase activity (GO:0051096)
Namespace: biological_process
Definition: Any process that activates or increases the activity of a helicase.
Synonyms: activation of helicase activity; stimulation of helicase activity; up regulation of helicase activity; up-regulation of helicase activity; upregulation of helicase activity
negative regulation of helicase activity (GO:0051097)
Namespace: biological_process
Definition: Any process that stops or reduces the activity of a helicase.
Synonyms: down regulation of helicase activity; down-regulation of helicase activity; downregulation of helicase activity; inhibition of helicase activity
regulation of binding (GO:0051098)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
positive regulation of binding (GO:0051099)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
Synonyms: activation of binding; stimulation of binding; up regulation of binding; up-regulation of binding; upregulation of binding
negative regulation of binding (GO:0051100)
Namespace: biological_process
Definition: Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
Synonyms: down regulation of binding; down-regulation of binding; downregulation of binding; inhibition of binding
regulation of DNA binding (GO:0051101)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
obsolete DNA ligation involved in DNA recombination (GO:0051102)
Namespace: biological_process
Definition: OBSOLETE. The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination.
Synonyms: DNA ligation during DNA recombination
Comment: The reason for obsoletion is that the term represents a molecular function.
obsolete DNA ligation involved in DNA repair (GO:0051103)
Namespace: biological_process
Definition: OBSOLETE. The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.
Synonyms: DNA ligation during DNA repair
Comment: The reason for obsoletion is that the term represents a molecular function.