LiteFold/GO huggingface dataset:
survivin complex (GO:1990713)
Namespace: cellular_component
Definition: A protein complex that negatively regulates apoptotic processes. Complex contains a component which belongs to the family of baculoviral IAP (inhibitor of apoptosis) repeat-containing proteins.
Synonyms: Baculoviral IAP repeat-containing protein 5 complex; survivin homodimer complex
Comment: An example of this is BIRC5 in human (UniProt symbol O15392) in PMID:10949038 (inferred from physical interaction).
hydroxyproline O-galactosyltransferase activity (GO:1990714)
Namespace: molecular_function
Definition: Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone.
Synonyms: HPGT
mRNA CDS binding (GO:1990715)
Namespace: molecular_function
Definition: Binding to an mRNA molecule coding sequence (CDS).
Synonyms: mRNA coding region binding; mRNA coding sequence binding
axonemal central apparatus (GO:1990716)
Namespace: cellular_component
Definition: Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules.
axonemal central bridge (GO:1990717)
Namespace: cellular_component
Definition: Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules.
axonemal central pair projection (GO:1990718)
Namespace: cellular_component
Definition: Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules.
C1 axonemal microtubule (GO:1990719)
Namespace: cellular_component
Definition: One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections.
Synonyms: C1 tubule
C2 axonemal microtubule (GO:1990720)
Namespace: cellular_component
Definition: One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections.
Synonyms: C2 tubule
DAPK1-calmodulin complex (GO:1990722)
Namespace: cellular_component
Definition: A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding.
Synonyms: death-associated protein kinase 1 - calmodulin complex
cytoplasmic periphery of the nuclear pore complex (GO:1990723)
Namespace: cellular_component
Definition: Cytoplasm situated in close proximity to a nuclear pore complex.
Synonyms: associated with the nuclear pore
galectin complex (GO:1990724)
Namespace: cellular_component
Definition: A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes.
Synonyms: galectin-1 complex; galectin-2 complex
Comment: An example of this is Galectin-1 in human (P09382) in PMID:15476813 (inferred from physical interaction).
cord factor receptor activity (GO:1990725)
Namespace: molecular_function
Definition: Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: TMD receptor activity; trehalose 6,6'-dimycolate receptor activity
Lsm1-7-Pat1 complex (GO:1990726)
Namespace: cellular_component
Definition: A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway.
tubulin folding cofactor complex (GO:1990727)
Namespace: cellular_component
Definition: A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.
mitotic spindle assembly checkpoint MAD1-MAD2 complex (GO:1990728)
Namespace: cellular_component
Definition: A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex.
Synonyms: MAD1-MAD2 complex
Comment: An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction).
VCP-NSFL1C complex (GO:1990730)
Namespace: cellular_component
Definition: A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.
Synonyms: p97-p47 complex
obsolete UV-damage excision repair, DNA incision (GO:1990731)
Namespace: biological_process
Definition: OBSOLETE. A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).
Synonyms: alternative excision repair, DNA incision; DNA incision involved in AER; DNA incision involved in alternative excision repair; DNA incision involved in UV-damage excision repair; DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair; DNA incision involved in UVDE-dependent excision repair; DNA incision involved in UVER; nucleic acid cleavage involved in UV-damage excision repair; UV-damaged DNA endonuclease-dependent excision repair, DNA incision; UVDE-dependent excision repair, DNA incision
Comment: This term was obsoleted because it represents a molecular function.
pyrenoid (GO:1990732)
Namespace: cellular_component
Definition: A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation.
titin-telethonin complex (GO:1990733)
Namespace: cellular_component
Definition: A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils.
Synonyms: Titin-Tcap complex
Comment: An example of this are TTN and TCAP in human (UniProt symbols Q8WZ42 and O15273 respectively) in PMID:16407954 (inferred from direct assay).
astral microtubule anchoring at mitotic spindle pole body (GO:1990734)
Namespace: biological_process
Definition: Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end.
gamma-tubulin complex localization to mitotic spindle pole body (GO:1990735)
Namespace: biological_process
Definition: Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body.
Synonyms: establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body; gamma-tubulin complex localisation to mitotic spindle pole body; gamma-tubulin complex localization to mitotic SPB
response to manganese-induced endoplasmic reticulum stress (GO:1990737)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus.
Synonyms: manganese-induced ER stress response; response to manganese-induced ER stress; response to Mn-induced ER stress
pseudouridine 5'-phosphatase activity (GO:1990738)
Namespace: molecular_function
Definition: Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.
obsolete non-selective anion channel activity (GO:1990740)
Namespace: molecular_function
Definition: OBSOLETE. Enables the non-selective, energy-independent passage of anions across a lipid bilayer down a concentration gradient.
Synonyms: nonselective anion channel activity
Comment: This term was made obsolete because it was added in error.
obsolete non-selective cation channel activity (GO:1990741)
Namespace: molecular_function
Definition: OBSOLETE. Enables the non-selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient.
Synonyms: nonselective cation channel activity
Comment: This term was made obsolete because it was added in error.
microvesicle (GO:1990742)
Namespace: cellular_component
Definition: An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm.
Synonyms: ectosome; extracellular microvesicle; shedding vesicle
protein sialylation (GO:1990743)
Namespace: biological_process
Definition: A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.
EARP complex (GO:1990745)
Namespace: cellular_component
Definition: A quatrefoil tethering complex required for endocytic recycling.
pancreatic trypsinogen secretion (GO:1990747)
Namespace: biological_process
Definition: The regulated release of trypsinogen from the cells of the exocrine pancreas.
Synonyms: pancreatic trypsinogen release
cellular detoxification (GO:1990748)
Namespace: biological_process
Definition: Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
polynucleotide adenylyltransferase activator activity (GO:1990749)
Namespace: molecular_function
Definition: Increases the activity of the enzyme polynucleotide adenylyltransferase.
obsolete axon shaft (GO:1990750)
Namespace: cellular_component
Definition: OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites.
Synonyms: axonal shaft
Comment: This term was made obsolete because it was added in error.
Schwann cell chemotaxis (GO:1990751)
Namespace: biological_process
Definition: The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
microtubule end (GO:1990752)
Namespace: cellular_component
Definition: Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end.
Comment: This term should be used when it is not possible to distinguish between the two microtubule ends, e.g. during image annotation. Whenever possible, please annotate to one of the more specific children GO:0035371 'microtubule plus-end' or GO:0036449 'microtubule minus-end'.
equatorial cell cortex (GO:1990753)
Namespace: cellular_component
Definition: The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression.
mitotic spindle microtubule depolymerization (GO:1990755)
Namespace: biological_process
Definition: The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle.
Synonyms: mitotic spindle microtubule depolymerisation
ubiquitin-like ligase-substrate adaptor activity (GO:1990756)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins.
Synonyms: protein binding, bridging involved in substrate recognition for ubiquitination; ubiquitin ligase substrate adaptor; ubiquitin ligase-substrate adaptor activity; UFM1 ligase-substrate adaptor activity
ubiquitin ligase activator activity (GO:1990757)
Namespace: molecular_function
Definition: Binds to and increases the activity of a ubiquitin ligase.
Synonyms: mitotic anaphase-promoting complex activator activity
mitotic sister chromatid biorientation (GO:1990758)
Namespace: biological_process
Definition: The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression.
osmolarity-sensing monoatomic cation channel activity (GO:1990760)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides.
Synonyms: osmolarity-sensing cation channel activity
growth cone lamellipodium (GO:1990761)
Namespace: cellular_component
Definition: A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments.
arrestin family protein binding (GO:1990763)
Namespace: molecular_function
Definition: Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.
myofibroblast contraction (GO:1990764)
Namespace: biological_process
Definition: The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast.
Synonyms: MF contraction; MFB contraction
colon smooth muscle contraction (GO:1990765)
Namespace: biological_process
Definition: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum.
prostaglandin receptor internalization (GO:1990767)
Namespace: biological_process
Definition: The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle.
gastric mucosal blood circulation (GO:1990768)
Namespace: biological_process
Definition: The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products.
Synonyms: stomach mucosal blood circulation
small intestine smooth muscle contraction (GO:1990770)
Namespace: biological_process
Definition: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.
clathrin-dependent extracellular exosome endocytosis (GO:1990771)
Namespace: biological_process
Definition: The clathrin-mediated endocytosis of an extracellular exosome.
Synonyms: clathrin-mediated extracellular exosome endocytosis; exosome related
substance P secretion (GO:1990772)
Namespace: biological_process
Definition: The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity.
matrix metallopeptidase secretion (GO:1990773)
Namespace: biological_process
Definition: The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins.
Synonyms: matrix metalloproteinase secretion; MMP secretion
endothelin production (GO:1990775)
Namespace: biological_process
Definition: The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions.
Synonyms: EDN1 production; EDN2 production; EDN3 production; endothelin secretion; endothelin-1 secretion; endothelin-2 production; endothelin-3 production
lipoprotein particle (GO:1990777)
Namespace: cellular_component
Definition: A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph.
glycoprotein Ib-IX-V complex (GO:1990779)
Namespace: cellular_component
Definition: A transmembrane signaling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation.
Synonyms: CD42; GPIb-IX-V complex; GPIb-V-IX complex
Comment: An example of this is GB1BA in human (P07359) in PMID:1730602 (inferred from direct assay).
cytoplasmic side of dendritic spine plasma membrane (GO:1990780)
Namespace: cellular_component
Definition: The leaflet of the plasma membrane in the dendritic spine region that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
response to immobilization stress combined with electrical stimulus (GO:1990781)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile.
protein tyrosine kinase binding (GO:1990782)
Namespace: molecular_function
Definition: Binding to protein tyrosine kinase.
Synonyms: tyrosine kinase binding
response to dsDNA (GO:1990784)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.
Synonyms: response to double-stranded DNA
response to water-immersion restraint stress (GO:1990785)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile.
Synonyms: response to immobilization stress combined with water immersion
cellular response to dsDNA (GO:1990786)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.
obsolete negative regulation of hh target transcription factor activity (GO:1990787)
Namespace: biological_process
Definition: OBSOLETE. Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling.
Synonyms: negative regulation of hedgehog target transcription factor
Comment: The reason for obsoletion is that this term represents a molecular function.
GLI-SUFU complex (GO:1990788)
Namespace: cellular_component
Definition: A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins.
Comment: An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay).
response to glial cell derived neurotrophic factor (GO:1990790)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus.
Synonyms: response to astrocyte-derived trophic factor; response to ATF; response to GDNF
dorsal root ganglion development (GO:1990791)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
Synonyms: DRG development
cellular response to glial cell derived neurotrophic factor (GO:1990792)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus.
Synonyms: cellular response to astrocyte-derived trophic factor; cellular response to ATF; cellular response to GDNF
substance P secretion, neurotransmission (GO:1990793)
Namespace: biological_process
Definition: The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter.
basolateral part of cell (GO:1990794)
Namespace: cellular_component
Definition: The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.
rod bipolar cell terminal bouton (GO:1990795)
Namespace: cellular_component
Definition: A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer.
photoreceptor cell terminal bouton (GO:1990796)
Namespace: cellular_component
Definition: A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light.
obsolete cholecystokinin secretion (GO:1990797)
Namespace: biological_process
Definition: OBSOLETE. The controlled release of cholecystokinin from a cell. Cholecystokinin is a peptide hormone that participates in pancreatic enzyme release in the gut and is also found in the brain.
Synonyms: CCK secretion
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
pancreas regeneration (GO:1990798)
Namespace: biological_process
Definition: The regrowth of a destroyed pancreas.
mitochondrial tRNA wobble position uridine thiolation (GO:1990799)
Namespace: biological_process
Definition: The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
obsolete protein phosphorylation involved in mitotic spindle assembly (GO:1990801)
Namespace: biological_process
Definition: OBSOLETE. Any protein phosphorylation that is involved in mitotic spindle assembly.
Synonyms: protein amino acid phosphorylation involved in mitotic spindle assembly; protein amino acid phosphorylation involved in spindle assembly involved in mitosis; protein phosphorylation involved in spindle assembly involved in mitosis
Comment: This term has been obsoleted because it represents a GO-CAM model.
obsolete protein phosphorylation involved in DNA double-strand break processing (GO:1990802)
Namespace: biological_process
Definition: OBSOLETE. Any protein phosphorylation that is required for DNA double-strand break processing.
Synonyms: protein amino acid phosphorylation involved in DNA double-strand break processing
Comment: This term has been obsoleted because it represents a GO-CAM model.