LiteFold/GO huggingface dataset:
obsolete protein O-GlcNAcylation via threonine (GO:0097370)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine.
Comment: The reason for obsoletion is that this term represents a molecular function.
MDM2/MDM4 family protein binding (GO:0097371)
Namespace: molecular_function
Definition: Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53.
histone H3K18 deacetylase activity, NAD-dependent (GO:0097372)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + NAD+ + H2O = histone H3 L-lysine (position 18) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K18 to NAD, producing nicotinamide.
Synonyms: NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone H3-K18 deacetylase activity; NAD-dependent histone H3K18 deacetylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
MCM core complex (GO:0097373)
Namespace: cellular_component
Definition: A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated.
Synonyms: MCM4/6/7 complex
sensory neuron axon guidance (GO:0097374)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.
spinal sensory neuron axon guidance (GO:0097375)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord.
interneuron axon guidance (GO:0097376)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions.
spinal cord interneuron axon guidance (GO:0097377)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord.
dorsal spinal cord interneuron axon guidance (GO:0097378)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord.
Synonyms: dorsal interneuron axon guidance
dorsal spinal cord interneuron posterior axon guidance (GO:0097379)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
Synonyms: dorsal interneuron caudal axon projection
dorsal spinal cord interneuron anterior axon guidance (GO:0097380)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
Synonyms: dorsal interneuron rostral axon projection
photoreceptor disc membrane (GO:0097381)
Namespace: cellular_component
Definition: Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
obsolete deoxynucleoside-diphosphatase activity (GO:0097382)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate.
Comment: This term was obsoleted because it represents an unnecessary grouping class.
dIDP phosphatase activity (GO:0097383)
Namespace: molecular_function
Definition: Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate.
Synonyms: deoxyinosine-diphosphatase activity
obsolete cellular lipid biosynthetic process (GO:0097384)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells.
Synonyms: cellular lipid anabolism; cellular lipid biosynthesis; cellular lipid formation; cellular lipid synthesis
Comment: The reason for obsoletion is that this term is redundant to GO:008610
programmed necrotic cell death in response to starvation (GO:0097385)
Namespace: biological_process
Definition: A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment).
Synonyms: necrotic cell death in response to starvation
glial cell projection (GO:0097386)
Namespace: cellular_component
Definition: A prolongation or process extending from a glial cell.
Synonyms: glial process; glial projection
capitate projection (GO:0097387)
Namespace: cellular_component
Definition: Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies).
chemokine (C-C motif) ligand 19 production (GO:0097388)
Namespace: biological_process
Definition: The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CCL19 production; EBI1 ligand chemokine production; ELC production; macrophage inflammatory protein-3-beta production; MIP-3-beta production
chemokine (C-C motif) ligand 21 production (GO:0097389)
Namespace: biological_process
Definition: The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CCL21 production
chemokine (C-X-C motif) ligand 12 production (GO:0097390)
Namespace: biological_process
Definition: The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CXCL12 production
chemokine (C-X-C motif) ligand 13 production (GO:0097391)
Namespace: biological_process
Definition: The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CXCL13 production
chemokine (C-X-C motif) ligand 16 production (GO:0097392)
Namespace: biological_process
Definition: The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CXCL16 production
telomeric repeat-containing RNA transcription (GO:0097393)
Namespace: biological_process
Definition: The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome.
Synonyms: TERRA transcription
obsolete telomeric repeat-containing RNA transcription by RNA polymerase II (GO:0097394)
Namespace: biological_process
Definition: OBSOLETE. The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter.
Synonyms: telomeric repeat-containing RNA transcription from RNA pol II promoter; telomeric RNA transcription from Pol II promoter; TERRA RNA transcription from RNA pol II promoter
Comment: This term was obsoleted because there is no evidence that telomeric RNA is specifically transcribed, but it may be a result of cryptic transcription. Biological processes exist to maintain telomeric DNA is a repressed state (subtelomeric heterochromatin formation ; GO:0031509).
response to interleukin-32 (GO:0097395)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus.
Synonyms: response to IL-32
response to interleukin-17 (GO:0097396)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.
Synonyms: response to IL-17
cellular response to interleukin-32 (GO:0097397)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus.
Synonyms: cellular response to IL-32
cellular response to interleukin-17 (GO:0097398)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.
Synonyms: cellular response to IL-17
interleukin-32-mediated signaling pathway (GO:0097399)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-32 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-32-mediated signaling pathway; IL-32-mediated signalling pathway; interleukin-32-mediated signalling pathway
interleukin-17-mediated signaling pathway (GO:0097400)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-17-mediated signaling pathway; IL-17-mediated signalling pathway; interleukin-17-mediated signalling pathway
neuroblast migration (GO:0097402)
Namespace: biological_process
Definition: The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.
Bunina body (GO:0097407)
Namespace: cellular_component
Definition: Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles.
fibrillary inclusion (GO:0097408)
Namespace: cellular_component
Definition: Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra.
glial cytoplasmic inclusion (GO:0097409)
Namespace: cellular_component
Definition: Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy.
Synonyms: GCI; Papp-Lantos body
hippocampal interneuron differentiation (GO:0097410)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron.
hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)
Namespace: biological_process
Definition: The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
Synonyms: HIF1alpha pathway; hypoxia-inducible factor signaling; hypoxia-inducible factor-1alpha signalling pathway
hyaline inclusion (GO:0097412)
Namespace: cellular_component
Definition: A glass-like, pale intracellular inclusion.
Synonyms: pale body
Lewy body (GO:0097413)
Namespace: cellular_component
Definition: Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein.
Synonyms: cytoplasmic inclusion
cortical Lewy body (GO:0097415)
Namespace: cellular_component
Definition: Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils.
Lewy body-like hyaline inclusion (GO:0097416)
Namespace: cellular_component
Definition: Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments.
Synonyms: LBHI
nematosome (GO:0097417)
Namespace: cellular_component
Definition: Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles.
neurofibrillary tangle (GO:0097418)
Namespace: cellular_component
Definition: Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
Synonyms: flame-shaped neurofibrillary tangle; star-shaped neurofibrillary tangle
Comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
Pick body (GO:0097419)
Namespace: cellular_component
Definition: Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E.
skein-like inclusion (GO:0097420)
Namespace: cellular_component
Definition: Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin.
liver regeneration (GO:0097421)
Namespace: biological_process
Definition: The regrowth of lost or destroyed liver.
tubular endosome (GO:0097422)
Namespace: cellular_component
Definition: A network of fine tubules in the vicinity of the Golgi complex and around the centriole.
Synonyms: coated tip
mitochondrion-associated adherens complex (GO:0097423)
Namespace: cellular_component
Definition: An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans.
Synonyms: MAC; mitochondrial adhaerens complex
nucleolus-associated heterochromatin (GO:0097424)
Namespace: cellular_component
Definition: Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus.
obsolete smooth endoplasmic reticulum part (GO:0097425)
Namespace: cellular_component
Definition: OBSOLETE. Any constituent part of the smooth endoplasmic reticulum (also called smooth ER, or SER).
Synonyms: SER subcomponent
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
glial filament (GO:0097426)
Namespace: cellular_component
Definition: An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes.
microtubule bundle (GO:0097427)
Namespace: cellular_component
Definition: An arrangement of closely apposed microtubules running parallel to each other.
Synonyms: microtubule fascicle
obsolete protein maturation by iron-sulfur cluster transfer (GO:0097428)
Namespace: biological_process
Definition: OBSOLETE. The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
Comment: The reason for obsoletion is that these BP terms represent MFs.
copper ion import across prospore membrane (GO:0097430)
Namespace: biological_process
Definition: The directed movement of copper ions from outside of a cell, across an ascospore-type prospore membrane and into the cytosol.
Synonyms: copper ion import into ascospore-type prospore; copper ion transport into forespores
dense body (GO:0097433)
Namespace: cellular_component
Definition: An electron dense body which may contain granules.
succinate:proton symporter activity (GO:0097434)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in).
Synonyms: succinate:hydrogen symporter activity
supramolecular fiber organization (GO:0097435)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
Synonyms: extracellular fibril organisation; extracellular fibril organization; extracellular fibril organization and biogenesis; fibril organisation; fibril organization
entry into dormancy (GO:0097436)
Namespace: biological_process
Definition: The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated.
Synonyms: induction of dormancy
maintenance of dormancy (GO:0097437)
Namespace: biological_process
Definition: The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated.
exit from dormancy (GO:0097438)
Namespace: biological_process
Definition: The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated.
Synonyms: release from dormancy
acquisition of desiccation tolerance (GO:0097439)
Namespace: biological_process
Definition: The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state.
apical dendrite (GO:0097440)
Namespace: cellular_component
Definition: A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.
CA3 pyramidal cell dendrite (GO:0097442)
Namespace: cellular_component
Definition: A dendrite of a hippocampal CA3 pyramidal cell.
sorting endosome (GO:0097443)
Namespace: cellular_component
Definition: A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.
Synonyms: MVB-tubule complex
spine apparatus (GO:0097444)
Namespace: cellular_component
Definition: A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum.
Synonyms: dense material
presynaptic active zone dense projection (GO:0097445)
Namespace: cellular_component
Definition: Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered.
Synonyms: active zone dense projection; pre-synaptic active zone dense projection
protein localization to eisosome filament (GO:0097446)
Namespace: biological_process
Definition: A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.
Synonyms: protein localization to linear eisosome
astrocyte projection (GO:0097449)
Namespace: cellular_component
Definition: A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.
Synonyms: astrocyte process; peripheral astrocyte process; vellous process
astrocyte end-foot (GO:0097450)
Namespace: cellular_component
Definition: Terminal process of astrocyte abutting non-neuronal surfaces in the brain.
Synonyms: astrocyte endfoot