LiteFold/GO huggingface dataset:
M/G1 phase-specific MADS box-forkhead transcription factor complex (GO:0097221)
Namespace: cellular_component
Definition: A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2.
Synonyms: PBF complex; PBF transcription complex; PCB binding factor complex; pombe cell cycle box binding factor complex
mitochondrial mRNA polyadenylation (GO:0097222)
Namespace: biological_process
Definition: The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails.
obsolete sperm part (GO:0097223)
Namespace: cellular_component
Definition: OBSOLETE. Any constituent part of a sperm, a mature male germ cell that develops from a spermatid.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
obsolete sperm connecting piece (GO:0097224)
Namespace: cellular_component
Definition: OBSOLETE. The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum.
Comment: The reason for obsoletion is that this term is equivalent to GO:0120212 sperm head-tail coupling apparatus.
sperm midpiece (GO:0097225)
Namespace: cellular_component
Definition: The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.
sperm annulus (GO:0097227)
Namespace: cellular_component
Definition: The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.
sperm principal piece (GO:0097228)
Namespace: cellular_component
Definition: The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
sperm end piece (GO:0097229)
Namespace: cellular_component
Definition: The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane.
cell motility in response to potassium ion (GO:0097230)
Namespace: biological_process
Definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus.
Synonyms: K+ facilitation of cell motility; potassium ion facilitation of cell motility
cell motility in response to calcium ion (GO:0097231)
Namespace: biological_process
Definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus.
Synonyms: Ca2+ facilitation of cell motility; calcium ion facilitation of cell motility
lamellar body membrane (GO:0097232)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.
alveolar lamellar body membrane (GO:0097233)
Namespace: cellular_component
Definition: The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
epidermal lamellar body membrane (GO:0097234)
Namespace: cellular_component
Definition: The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.
obsolete positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter (GO:0097235)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation (GO:0097236)
Namespace: biological_process
Definition: OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of zinc ions.
Comment: This term was obsoleted because it represents a GO-CAM model.
cellular response to toxic substance (GO:0097237)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
cellular response to methylglyoxal (GO:0097238)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.
obsolete positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal (GO:0097239)
Namespace: biological_process
Definition: OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus.
Comment: This term was obsoleted because it represents a GO-CAM model.
chromosome attachment to the nuclear envelope (GO:0097240)
Namespace: biological_process
Definition: The process in which chromatin is anchored to the nuclear envelope.
Synonyms: attachment of chromatin to nuclear envelope
hematopoietic stem cell migration to bone marrow (GO:0097241)
Namespace: biological_process
Definition: The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
Synonyms: hematopoietic stem cell homing; hemopoietic stem cell migration to bone marrow; progenitor cell homing
amyloid-beta clearance (GO:0097242)
Namespace: biological_process
Definition: The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
Synonyms: beta-amyloid clearance
flavonoid binding (GO:0097243)
Namespace: molecular_function
Definition: Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge.
flavonol binding (GO:0097244)
Namespace: molecular_function
Definition: Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone.
catechin binding (GO:0097246)
Namespace: molecular_function
Definition: Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure.
maintenance of protein location in cell cortex of cell tip (GO:0097248)
Namespace: biological_process
Definition: A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell.
mitochondrial respirasome assembly (GO:0097250)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of respiratory enzyme complexes I, III and IV of the mitochondrial inner membrane to form a large supercomplex.
Synonyms: mitochondrial respiratory chain supercomplex assembly; mitochondrial respiratory supercomplex assembly
leukotriene B4 biosynthetic process (GO:0097251)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.
Synonyms: leukotriene B4 anabolism; leukotriene B4 biosynthesis; leukotriene B4 formation; leukotriene B4 synthesis; LTB4 anabolism; LTB4 biosynthesis; LTB4 formation; LTB4 synthesis
oligodendrocyte apoptotic process (GO:0097252)
Namespace: biological_process
Definition: Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.
Synonyms: oligodendrocyte apoptosis
beta-hydroxybutyrate transmembrane transporter activity (GO:0097253)
Namespace: molecular_function
Definition: Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid.
Synonyms: (R)-3-hydroxybutyrate transmembrane transporter activity; 3-hydroxybutanoic acid transmembrane transporter activity
renal tubular secretion (GO:0097254)
Namespace: biological_process
Definition: The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.
R2TP complex (GO:0097255)
Namespace: cellular_component
Definition: A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
phenyllactate dehydrogenase (NAD+) activity (GO:0097256)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH.
Comment: This enzymatic activity is usually negligible, but may become prominent when phenylalanine levels are abnormally high as in the human disease phenylketonuria (PKU).
leukotriene B4 12-hydroxy dehydrogenase activity (GO:0097257)
Namespace: molecular_function
Definition: Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+.
Synonyms: leukotriene B4 12-hydroxydehydrogenase activity
20-hydroxy-leukotriene B4 omega oxidase activity (GO:0097258)
Namespace: molecular_function
Definition: Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase].
Synonyms: 20-hydroxy-leukotriene B4 omega-oxidase activity; 20-hydroxy-leukotriene B4 omega-oxidation
obsolete eoxin A4 synthase activity (GO:0097260)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: leukotriene A4 = eoxin A4.
Comment: The reason for obsoletion is that this term is equivalent to leukotriene-C4 synthase activity.
eoxin C4 synthase activity (GO:0097261)
Namespace: molecular_function
Definition: Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4.
eoxin D4 synthase activity (GO:0097262)
Namespace: molecular_function
Definition: Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid.
eoxin E4 synthase activity (GO:0097263)
Namespace: molecular_function
Definition: Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine.
self proteolysis (GO:0097264)
Namespace: biological_process
Definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
Synonyms: autolysis; self-proteolysis
5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity (GO:0097265)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+.
Synonyms: 5(S)-HETE dehydrogenase activity; 5-HETE dehydrogenase activity; 5-hydroxy-eicosatetraenoic acid dehydrogenase activity
phenylacetyl-CoA 1,2-epoxidase activity (GO:0097266)
Namespace: molecular_function
Definition: Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+.
Synonyms: phenylacetyl-CoA epoxidase activity; phenylacetyl-CoA monooxygenase activity; ring 1,2-phenylacetyl-CoA epoxidase activity
omega-hydroxylase P450 pathway (GO:0097267)
Namespace: biological_process
Definition: The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation.
Synonyms: P450 omega-hydroxylase pathway
cytoophidium (GO:0097268)
Namespace: cellular_component
Definition: A filamentous, membrane-less subcellular structure composed primarily of polymerized metabolic enzymes, most notably cytidine triphosphate synthase (CTPS). Cytoophidia are evolutionarily conserved structures found across archaea, bacteria, and eukaryotes.
all-trans-decaprenyl-diphosphate synthase activity (GO:0097269)
Namespace: molecular_function
Definition: Catalysis of the reaction: 7 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate.
Synonyms: (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity; 2-trans,6-trans-farnesyl diphosphate activity; decaprenyl pyrophosphate synthetase activity; decaprenyl-diphosphate synthase activity; polyprenylpyrophosphate synthetase activity; terpenoidallyltransferase activity; terpenyl pyrophosphate synthetase activity; trans-prenyltransferase activity
dishabituation (GO:0097270)
Namespace: biological_process
Definition: The temporary recovery of response to a stimulus when a novel stimulus is added.
protein localization to bud neck (GO:0097271)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained at, a location within a cellular bud neck.
Synonyms: protein localisation to bud neck; protein localization to cellular bud neck
ammonium homeostasis (GO:0097272)
Namespace: biological_process
Definition: Any biological process involved in the maintenance of an internal steady state of ammonium.
Synonyms: ammonia homeostasis
obsolete creatinine homeostasis (GO:0097273)
Namespace: biological_process
Definition: OBSOLETE. Any biological process involved in the maintenance of an internal steady state of creatinine.
Comment: This term was obsoleted because this process does not exist: creatinine is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
obsolete urea homeostasis (GO:0097274)
Namespace: biological_process
Definition: OBSOLETE. Any biological process involved in the maintenance of an internal steady state of urea.
Comment: This term was obsoleted because this process does not exist: urea is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
intracellular ammonium homeostasis (GO:0097275)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell.
Synonyms: cellular ammonia homeostasis; cellular ammonium homeostasis
obsolete cellular creatinine homeostasis (GO:0097276)
Namespace: biological_process
Definition: OBSOLETE. Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell.
Comment: This term was obsoleted because this process does not exist: creatinine is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
obsolete cellular urea homeostasis (GO:0097277)
Namespace: biological_process
Definition: OBSOLETE. Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell.
Comment: This term was obsoleted because this process does not exist: urea is a waste product, there are no biological processes to maintain its level, although some mutants accumulate excesses.
complement-dependent cytotoxicity (GO:0097278)
Namespace: biological_process
Definition: Cell killing caused by the membrane attack complex formed following complement activation.
histamine secretion mediated by IgE immunoglobulin (GO:0097279)
Namespace: biological_process
Definition: Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen.
Synonyms: histamine secretion mediated by IgE antibody; Ig-mediated histamine release
histamine secretion mediated by immunoglobulin (GO:0097280)
Namespace: biological_process
Definition: Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface.
immune complex formation (GO:0097281)
Namespace: biological_process
Definition: The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus.
Synonyms: antibody-mediated agglutination
immunoglobulin-mediated neutralization (GO:0097282)
Namespace: biological_process
Definition: The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin.
Synonyms: antibody-mediated neutralization
keratinocyte apoptotic process (GO:0097283)
Namespace: biological_process
Definition: Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.
Synonyms: keratinocyte apoptosis
hepatocyte apoptotic process (GO:0097284)
Namespace: biological_process
Definition: Any apoptotic process in a hepatocyte, the main structural component of the liver.
Synonyms: hepatocyte apoptosis
obsolete cell-type specific apoptotic process (GO:0097285)
Namespace: biological_process
Definition: OBSOLETE. Any apoptotic process in a specific cell type.
Synonyms: cell-type specific apoptosis
Comment: This term was made obsolete because it was an unnecessary grouping term.
7-cyano-7-deazaguanine metabolic process (GO:0097287)
Namespace: biological_process
Definition: The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo.
Synonyms: 7-cyano-7-deazaguanine metabolism
7-cyano-7-deazaguanine biosynthetic process (GO:0097288)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo.
Synonyms: 7-cyano-7-deazaguanine anabolism; 7-cyano-7-deazaguanine biosynthesis; 7-cyano-7-deazaguanine formation; 7-cyano-7-deazaguanine synthesis
obsolete alpha-ribazole metabolic process (GO:0097289)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12).
Synonyms: alpha-ribazole metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete alpha-ribazole biosynthetic process (GO:0097290)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12).
Synonyms: alpha-ribazole anabolism; alpha-ribazole biosynthesis; alpha-ribazole formation; alpha-ribazole synthesis
Comment: This term was obsoleted because it represents a molecular function.
renal phosphate ion absorption (GO:0097291)
Namespace: biological_process
Definition: A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
Synonyms: renal phosphate absorption
XMP metabolic process (GO:0097292)
Namespace: biological_process
Definition: The chemical reactions and pathways involving XMP, xanthosine monophosphate.
Synonyms: XMP metabolism
XMP biosynthetic process (GO:0097293)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate.
Synonyms: XMP anabolism; XMP biosynthesis; XMP formation; XMP synthesis
'de novo' XMP biosynthetic process (GO:0097294)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors.
Synonyms: 'de novo' XMP anabolism; 'de novo' XMP biosynthesis; 'de novo' XMP formation; 'de novo' XMP synthesis
morphine biosynthetic process (GO:0097295)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum.
Synonyms: morphine anabolism; morphine biosynthesis; morphine formation; morphine synthesis