LiteFold/GO huggingface dataset:
cellular bud neck contractile ring (GO:0000142)
Namespace: cellular_component
Definition: A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.
Synonyms: neck ring
cellular bud neck septin ring (GO:0000144)
Namespace: cellular_component
Definition: A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange.
exocyst (GO:0000145)
Namespace: cellular_component
Definition: A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
Synonyms: exocyst complex; Sec6/8 complex
microfilament motor activity (GO:0000146)
Namespace: molecular_function
Definition: A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.
Synonyms: actin filament motor activity; actin-activated ATPase activity; actin-dependent ATPase activity; actin-filament motor activity; muscle motor activity; myosin ATPase activity
actin cortical patch assembly (GO:0000147)
Namespace: biological_process
Definition: Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.
1,3-beta-D-glucan synthase complex (GO:0000148)
Namespace: cellular_component
Definition: A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
Synonyms: (1->3)-beta-glucan synthase complex; 1,3-beta-glucan synthase complex
SNARE binding (GO:0000149)
Namespace: molecular_function
Definition: Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
Synonyms: SNAP receptor binding
DNA strand exchange activity (GO:0000150)
Namespace: molecular_function
Definition: Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
Synonyms: RecA-family recombinase activity; recombinase activity; strand exchange activity; strand transferase
Comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'.
ubiquitin ligase complex (GO:0000151)
Namespace: cellular_component
Definition: A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
nuclear ubiquitin ligase complex (GO:0000152)
Namespace: cellular_component
Definition: A ubiquitin ligase complex found in the nucleus.
cytoplasmic ubiquitin ligase complex (GO:0000153)
Namespace: cellular_component
Definition: A ubiquitin ligase complex found in the cytoplasm.
rRNA modification (GO:0000154)
Namespace: biological_process
Definition: The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.
Synonyms: rRNA editing
Comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
phosphorelay sensor kinase activity (GO:0000155)
Namespace: molecular_function
Definition: Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
Synonyms: two-component sensor activity; two-component sensor molecule; two-component system sensor activity
phosphorelay response regulator activity (GO:0000156)
Namespace: molecular_function
Definition: Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
Synonyms: two-component response regulator activity
protein phosphatase type 2A complex (GO:0000159)
Namespace: cellular_component
Definition: A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
Synonyms: PP2A complex; PP2A-pi; PP2a-protector; protein phosphatase 2 complex
obsolete osmosensory signaling MAPK cascade (GO:0000161)
Namespace: biological_process
Definition: OBSOLETE. A MAPK cascade that starts with the activation of a Ssk2/Win1 family MAP3K, which activates a Pbs2/Wis1 family MAP2K, resulting in the activation of a Hog1/Sty1 family MAPK. Hog1 then translocates from the cytosol into the nucleus where it affects the expression of a large number of genes. This cascade is activated by hyperosmolarity or other abiotic stresses and results in cellular responses such as cell cycle arrest.
Synonyms: activation of MAPK activity involved in osmosensory signaling pathway; activation of MAPKK activity during osmolarity sensing; activation of MAPKK activity involved in osmosensory signaling pathway; activation of MAPKKK activity during osmolarity sensing; activation of MAPKKK activity involved in osmosensory signaling pathway; activation of Pbs2 kinase; High Osmolarity Glycerol (HOG) MAPK pathway; Hog1 MAPK pathway; Hog1/Sty1 stress-activated MAPK cascade; inactivation of MAPK activity involved in osmosensory signaling pathway; MAPK cascade involved in osmosensory signaling pathway; MAPKKK cascade during osmolarity sensing; MAPKKK cascade involved in osmosensory signaling pathway; MAPKKK cascade involved in osmosensory signalling pathway; osmolarity sensing, activation of MAP kinase kinase activity; osmolarity sensing, activation of MAP kinase kinase kinase activity; osmolarity sensing, activation of MAPK activity; osmolarity sensing, activation of MAPKK activity; osmolarity sensing, activation of MAPKKK activity; osmolarity sensing, MAPKKK cascade; termination of MAPK activity during osmolarity sensing
Comment: This term was obsoleted because it represents the same process as p38MAPK cascade ; GO:0038066.
L-tryptophan biosynthetic process (GO:0000162)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate.
Synonyms: aromatic amino acid family biosynthetic process, anthranilate pathway; L-tryptophan anabolism; L-tryptophan biosynthesis; tryptophan biosynthetic process; tryptophan formation; tryptophan synthesis
protein phosphatase type 1 complex (GO:0000164)
Namespace: cellular_component
Definition: A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.
MAPK cascade (GO:0000165)
Namespace: biological_process
Definition: An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
Synonyms: ERK/MAPK cascade; MAP kinase cascade; MAP kinase kinase kinase cascade; MAPK signal transduction; MAPK signaling; MAPK signalling; MAPKKK cascade; MAPKKK cascade during sporulation; mitogen-activated protein kinase cascade
Comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
nucleotide binding (GO:0000166)
Namespace: molecular_function
Definition: Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
obsolete sphingosine hydroxylase activity (GO:0000170)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydroxylation of sphingolipid long chain bases.
Comment: The reason for obsoletion is that this term is equivalent to sphingolipid C4-monooxygenase activity.
ribonuclease MRP activity (GO:0000171)
Namespace: molecular_function
Definition: Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.
Synonyms: RNase MRP
ribonuclease MRP complex (GO:0000172)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
Synonyms: ribonuclease mitochondrial RNA processing complex; RNase MRP complex
obsolete inactivation of MAPK (mating sensu Saccharomyces) (GO:0000174)
Namespace: biological_process
Definition: OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.
Synonyms: inactivation of MAPK (mating sensu Saccharomyces)
Comment: This term was made obsolete because it is a gene product specific term.
3'-5'-RNA exonuclease activity (GO:0000175)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
Synonyms: 3'-5' exoribonuclease activity; 3'-5'-exoribonuclease activity
nuclear exosome (RNase complex) (GO:0000176)
Namespace: cellular_component
Definition: A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms: eukaryotic exosome multienzyme ribonuclease complex; nuclear exosome (ribonuclease complex); nuclear exosome multienzyme ribonuclease complex
cytoplasmic exosome (RNase complex) (GO:0000177)
Namespace: cellular_component
Definition: A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms: cytoplasmic exosome (ribonuclease complex); cytoplasmic exosome multienzyme ribonuclease complex; prokaryotic exosome multienzyme ribonuclease complex
exosome (RNase complex) (GO:0000178)
Namespace: cellular_component
Definition: A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms: exosome (ribonucleasease complex); exosome multienzyme ribonuclease complex
Comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
rRNA (adenine-N6,N6-)-dimethyltransferase activity (GO:0000179)
Namespace: molecular_function
Definition: Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.
Synonyms: 18S rRNA dimethylase activity; dimethyladenosine transferase activity; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity
obsolete cytosolic large ribosomal subunit (GO:0000180)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: cytosolic large ribosomal subunit
Comment: This term was made obsolete because more specific children exist.
obsolete cytosolic small ribosomal subunit (GO:0000181)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: cytosolic small ribosomal subunit
Comment: This term was made obsolete because more specific children exist.
rDNA binding (GO:0000182)
Namespace: molecular_function
Definition: Binding to a DNA sequence encoding a ribosomal RNA.
Synonyms: ribosomal DNA binding
rDNA heterochromatin formation (GO:0000183)
Namespace: biological_process
Definition: The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3.
Synonyms: chromatin silencing at rDNA; chromatin silencing at ribosomal DNA; heterochromatic silencing at rDNA; rDNA chromatin silencing; rDNA heterochromatin assembly
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)
Namespace: biological_process
Definition: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Synonyms: mRNA breakdown, nonsense-mediated decay; mRNA catabolic process, nonsense-mediated; mRNA catabolism, nonsense-mediated; mRNA degradation, nonsense-mediated decay; nonsense-mediated mRNA decay; nuclear mRNA catabolic process, nonsense-mediated decay
obsolete activation of MAPKKK activity (GO:0000185)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
Synonyms: activation of MAP kinase kinase kinase; activation of MAP3K activity; activation of MAPKKK activity during sporulation; positive regulation of MAP kinase kinase kinase activity; positive regulation of MAPKKK activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete activation of MAPKK activity (GO:0000186)
Namespace: biological_process
Definition: OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
Synonyms: activation of MAP kinase kinase activity; activation of MAP/ERK kinase kinase; activation of MAP2K activity; activation of MAPKK activity during sporulation; positive regulation of MAPKK activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete activation of MAPK activity (GO:0000187)
Namespace: biological_process
Definition: OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
Synonyms: activation of MAP kinase; activation of MAPK activity during sporulation; MAPK activation
Comment: This term was obsoleted because it represents a molecular function.
obsolete inactivation of MAPK activity (GO:0000188)
Namespace: biological_process
Definition: OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase.
Synonyms: inactivation of MAPK during sporulation; termination of MAPK activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete MAPK import into nucleus (GO:0000189)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation.
Synonyms: nuclear translocation of MAPK
Comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
obsolete MAPKKK cascade (pseudohyphal growth) (GO:0000190)
Namespace: biological_process
Definition: OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth.
Synonyms: MAPKKK cascade (pseudohyphal growth)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete activation of MAPKKK (pseudohyphal growth) (GO:0000191)
Namespace: biological_process
Definition: OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth.
Synonyms: activation of MAPKKK (pseudohyphal growth)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete activation of MAPKK (pseudohyphal growth) (GO:0000192)
Namespace: biological_process
Definition: OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth.
Synonyms: activation of MAPKK (pseudohyphal growth)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete activation of MAPK (pseudohyphal growth) (GO:0000193)
Namespace: biological_process
Definition: OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.
Synonyms: activation of MAPK (pseudohyphal growth)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete inactivation of MAPK (pseudohyphal growth) (GO:0000194)
Namespace: biological_process
Definition: OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.
Synonyms: inactivation of MAPK (pseudohyphal growth)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete nuclear translocation of MAPK (pseudohyphal growth) (GO:0000195)
Namespace: biological_process
Definition: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth.
Synonyms: nuclear translocation of MAPK (pseudohyphal growth)
Comment: This term was made obsolete because it is a gene product specific term.
cell integrity MAPK cascade (GO:0000196)
Namespace: biological_process
Definition: A MAPK cascade that specifically ensures the maintenance and regulation of cellular structure in response to external signals, including plasma membrane stretching or cell wall alteration, to coordinate cellular responses such as growth, differentiation, and stress adaptation, thereby preserving cell integrity. Contains the  SLT2 (S.cerevisiae)/Pmk1 (S.pombe) MAP kinase or orthologs.
Synonyms: cell integrity MAPK pathway; cell wall integrity MAPK cascade; CWI pathway; Mpk1 cascade; Pmk1 MAPK cell integrity signaling; Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway; PMK1-MAPK signal transduction pathway; Slt2 cascade
obsolete activation of MAPKKK activity involved in cell wall organization or biogenesis (GO:0000197)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis.
Synonyms: activation of MAP kinase kinase kinase activity during cell wall biogenesis; activation of MAPKKK activity involved in cell wall biogenesis; activation of MAPKKK activity involved in cell wall integrity; cell wall biogenesis, activation of MAP kinase kinase kinase activity; cell wall biogenesis, activation of MAPKKK activity
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete activation of MAPKK activity involved in cell wall organization or biogenesis (GO:0000198)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis.
Synonyms: activation of MAP kinase kinase activity during cell wall biogenesis; activation of MAPKK activity involved in cell wall biogenesis; activation of MAPKK activity involved in cell wall integrity; cell wall biogenesis, activation of MAP kinase kinase activity; cell wall biogenesis, activation of MAPKK activity
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete activation of MAPK activity involved in cell wall organization or biogenesis (GO:0000199)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.
Synonyms: activation of MAPK activity involved in cell wall biogenesis; activation of MAPK activity involved in cell wall integrity; cell wall biogenesis, activation of MAPK activity
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete inactivation of MAPK activity involved in cell wall organization or biogenesis (GO:0000200)
Namespace: biological_process
Definition: OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis.
Synonyms: cell wall biogenesis, inactivation of MAPK activity; cell wall biogenesis, termination of MAPK activity; inactivation of MAPK activity involved in cell wall integrity; inactivation of MAPK activity involved in cell wall organization or biogenesis; termination of MAPK activity during cell wall biogenesis
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete MAPK import into nucleus involved in cell wall organization or biogenesis (GO:0000201)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis.
Synonyms: cell wall biogenesis, MAPK import into nucleus; cell wall biogenesis, nuclear translocation of MAPK; MAPK import into nucleus involved in cell wall biogenesis; MAPK import into nucleus involved in cell wall integrity; nuclear translocation of MAPK involved in cell wall biogenesis; nuclear translocation of MAPK involved in cell wall integrity
Comment: The reason for obsoletion is that this term represents a GO-CAM model.