LiteFold/GO huggingface dataset:
metacyclogenesis (GO:0140384)
Namespace: biological_process
Definition: The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania.
amino acid transaminase activity (GO:0140385)
Namespace: molecular_function
Definition: Transfer of an amino group from an amino acid to an acceptor, usually a 2-oxo acid.
tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity (GO:0140386)
Namespace: molecular_function
Definition: Catalysis of the reaction: cytidine(4) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA + S-adenosyl-L-homocysteine + H+. Acts on  cytidine(4) on tRNAPro and tRNAGly(GCC), and on adenosine(4) in tRNAHis.
negative regulation of L-glutamate biosynthetic process (GO:0140387)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate biosynthetic process.
Synonyms: negative regulation of glutamate biosynthetic process; negative regulation of L-glutamate biosynthesis
protein translocation chaperone activity (GO:0140388)
Namespace: molecular_function
Definition: Binding to the exposed unfolded portion of a polypeptide as it emerges from a membrane translocation channel/pore to drive its unidirectional transport across a membrane. Iterative cycles of ATP-dependent binding/rebinding by the chaperone prevents back sliding and drive vectorial transport.
Synonyms: import motor chaperone activity; translocation ratchet activity
pattern recognition receptor complex (GO:0140389)
Namespace: cellular_component
Definition: A signaling receptor complex that combines with a pathogen-associated molecular pattern (PAMP), a structure conserved among pathogenic organisms, to initiate an innate immune response.
Synonyms: PAMP receptor complex
positive regulation of acetyl-CoA biosynthesis (GO:0140390)
Namespace: biological_process
Definition: Any process that increases the rate, frequency, or extent of acetyl-CoA biosynthetic process.
negative regulation of acetyl-CoA biosynthesis (GO:0140391)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of acetyl-CoA biosynthetic process.
extracellular protein-containing complex (GO:0140392)
Namespace: cellular_component
Definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together outside a cell.
Synonyms: extracellular protein complex
norsolorinic acid ketoreductase activity (GO:0140393)
Namespace: molecular_function
Definition: Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH.
ABC-type azole transporter activity (GO:0140394)
Namespace: molecular_function
Definition: Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out).
Synonyms: ATPase-coupled azole transmembrane transporter activity; azole ABC transporter activity
averantin hydroxylase activity (GO:0140395)
Namespace: molecular_function
Definition: Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis.
5'-hydroxyaverantin dehydrogenase activity (GO:0140396)
Namespace: molecular_function
Definition: Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH.
versiconal hemiacetal acetate esterase activity (GO:0140397)
Namespace: molecular_function
Definition: Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate.
versicolorin B desaturase activity (GO:0140398)
Namespace: molecular_function
Definition: Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
aflatoxin B synthase activity (GO:0140399)
Namespace: molecular_function
Definition: Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 = aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2).
embryonic sheath (GO:0140400)
Namespace: cellular_component
Definition: A specialized, transient apical extracellular matrix (aECM) that overlays the apical surface of the embryonic epidermis in Caenorhabditis elegans. It is secreted just prior to the start of embryonic elongation and acts as a mechanical scaffold to maintain embryonic integrity, distribute actomyosin-dependent stress, and anchor developing muscles.
effector-mediated suppression of host innate immune response (GO:0140403)
Namespace: biological_process
Definition: A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: effector dependent suppression of host immune innate response by symbiont; effector triggered suppression of host immune innate response by symbiont; effector-dependent suppression of host immune innate response by symbiont; effector-mediated suppression of host immune innate response by symbiont; effector-mediated suppression of host innate immune response by symbiont; effector-mediated suppression of host innate immunity; effector-triggered suppression of host immune innate response by symbiont
effector-mediated perturbation of host innate immune response by symbiont (GO:0140404)
Namespace: biological_process
Definition: A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: effector mediated modulation of host immune response by symbiont; effector triggered modulation of host immune response by symbiont; effector-dependent modulation of host immune response by symbiont; effector-mediated modulation of host immunity; effector-mediated modulation of host innate immune response by symbiont; effector-triggered modulation of host immune response by symbiont
spindle pole body-led chromosome movement during mitotic interphase (GO:0140405)
Namespace: biological_process
Definition: A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase.
L-alanine export across the plasma membrane (GO:0140406)
Namespace: biological_process
Definition: The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region.
L-alanine:proton antiporter activity (GO:0140407)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out).
regulation of mRNA alternative polyadenylation (GO:0140408)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation.
monoatomic cation:bicarbonate symporter activity (GO:0140410)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in).
Synonyms: monoatomic cation:hydrogencarbonate symporter activity; solute:bicarbonate symporter activity
zinc:bicarbonate symporter activity (GO:0140412)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in).
Synonyms: zinc:hydrogencarbonate symporter activity
zinc:bicarbonate:selenite symporter activity (GO:0140413)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out).
Synonyms: zinc:hydrogencarbonate:selenate symporter activity
phosphopantetheine-dependent carrier activity (GO:0140414)
Namespace: molecular_function
Definition: Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate.
Synonyms: carrier protein activity
effector-mediated perturbation of host defenses by symbiont (GO:0140415)
Namespace: biological_process
Definition: A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: effector-mediated modulation of host defenses by symbiont
transcription regulator inhibitor activity (GO:0140416)
Namespace: molecular_function
Definition: A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.
Synonyms: DNA-binding transcription factor inhibitor activity
Comment: Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA.
intracellularly ATP-gated calcium channel activity (GO:0140417)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts.
Synonyms: ATP-sensitive calcium-release channel activity
effector-mediated perturbation of host process by symbiont (GO:0140418)
Namespace: biological_process
Definition: A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: effector mediated modulation of host process by symbiont; effector triggered modulation of host process by symbiont; effector-dependent modulation of host process by symbiont; effector-mediated modulation of host process by symbiont
endocytic heme import into cell (GO:0140421)
Namespace: biological_process
Definition: The directed movement into cell of externally available heme by receptor-mediated endocytosis.
Synonyms: heme assimilation
effector-mediated suppression of host pattern-triggered immunity signaling (GO:0140423)
Namespace: biological_process
Definition: A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants.
Synonyms: effector-mediated suppression of host pattern recognition receptor signaling; effector-mediated suppression of host PRR signaling; effector-mediated suppression of host PRR signalling; effector-mediated suppression of pattern-triggered immunity signaling; effector-mediated suppression of PTI signalling
galactose import across plasma membrane (GO:0140425)
Namespace: biological_process
Definition: The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol.
pathogen-associated molecular pattern receptor signaling pathway (GO:0140426)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
Synonyms: MAMP-triggered immunity signalling; PAMP receptor signaling pathway; PAMP-triggered immunity signalling pathway; pathogen-associated molecular pattern signalling; PTI signalling
positive regulation of mitotic sister chromatid biorientation (GO:0140429)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed.
Synonyms: correction of merotelic kinetochore attachment, mitotic; correction of mono-orientation defects; correction of syntelic kinetochore attachment, mitotic; repair of mitotic merotelic kinetochore attachment defect; repair of mitotic merotelic kinetochore attachment defects; repair of mitotic mono-orientation defect; repair of mitotic mono-orientation defects
positive regulation of chromosome passenger complex localization to kinetochore (GO:0140430)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore.
DNA-(abasic site) binding (GO:0140431)
Namespace: molecular_function
Definition: Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base.
Synonyms: DNA AP site binding; DNA-(apurinic site) binding; DNA-(apurinic site/apyrimidinic site) binding; DNA-(apyrimidinic site) binding
regulation of protein localization to meiotic spindle pole body (GO:0140433)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body.
positive regulation of protein localization to meiotic spindle pole body (GO:0140434)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body.
protein stearoylation (GO:0140438)
Namespace: biological_process
Definition: The covalent attachment of a stearoyl group to an amino acid in a protein.
protein-cysteine S-stearoyltransferase activity (GO:0140439)
Namespace: molecular_function
Definition: Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein].
protein-cysteine S-oleoyltransferase activity (GO:0140440)
Namespace: molecular_function
Definition: Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein].
mitochondrion-plasma membrane adaptor activity (GO:0140443)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.
Synonyms: mitochondrion plasma membrane adaptor activity; mitochondrion plasma membrane tether activity; plasma membrane-mitochondrion adaptor activity; plasma membrane-mitochondrion tether activity
cytoskeleton-nuclear membrane anchor activity (GO:0140444)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane.
Synonyms: cytoskeletal protein-nuclear membrane adaptor activity; cytoskeletal protein-nuclear membrane anchor activity; cytoskeleton nuclear membrane anchor activity; nuclear membrane-cytoskeleton anchor activity
chromosome, telomeric repeat region (GO:0140445)
Namespace: cellular_component
Definition: A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop.
fumigermin biosynthetic process (GO:0140446)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus.
Synonyms: fumigermin anabolism; fumigermin biosynthesis; fumigermin formation; fumigermin synthesis
cytokine precursor processing (GO:0140447)
Namespace: biological_process
Definition: The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine.
Synonyms: interleukin maturation; interleukin processing
signaling receptor ligand precursor processing (GO:0140448)
Namespace: biological_process
Definition: The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.
Synonyms: ligand maturation; signal maturation
centromere-nuclear envelope anchor activity (GO:0140449)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location.
Synonyms: centromere nuclear envelope anchor activity; centromere nuclear envelope tether activity; centromere-inner nuclear envelope anchor activity; centromere-inner nuclear envelope tether activity; chromosome, centromeric region-nuclear envelope anchor activity; nuclear envelope-centromere anchor activity; nuclear envelope-centromere tether activity
protein targeting to Golgi apparatus (GO:0140450)
Namespace: biological_process
Definition: The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation).
protein aggregate center (GO:0140453)
Namespace: cellular_component
Definition: Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.
Synonyms: PAC; protein aggregate centre
protein aggregate center assembly (GO:0140454)
Namespace: biological_process
Definition: The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.
Synonyms: PAC assembly; protein aggregate center formation; protein aggregate centre assembly
cytoplasm protein quality control (GO:0140455)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.
initial meiotic spindle pole body separation (GO:0140456)
Namespace: biological_process
Definition: The release of duplicated meiotic spindle pole bodies (SPBs).
Synonyms: initial spindle pole body separation involved in meiosis I; meiotic spindle pole body duplication
protein demethylase activity (GO:0140457)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from a protein.
response to Gram-positive bacterium (GO:0140459)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium.
response to Gram-negative bacterium (GO:0140460)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium.
obsolete pericentric heterochromatin organization (GO:0140462)
Namespace: biological_process
Definition: OBSOLETE. The organization of chromatin into heterochromatin at the pericentric region of a chromosome.
Comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
chromatin-protein adaptor activity (GO:0140463)
Namespace: molecular_function
Definition: An adaptor activity that brings together a protein and a region of the chromatin, such as a nucleosome, to establish or maintain the chromatin localization of the protein, or the complex to which it belongs.
Synonyms: chromatin adaptor; chromatin adaptor activity; chromatin receptor; chromatin recruitment; chromatin-protein adaptor; protein-chromatin adaptor activity
subnuclear spatial organization of silent mating-type cassette heterochromatin (GO:0140464)
Namespace: biological_process
Definition: The localization of silent mating-type cassette heterochromatin at a specific location in the nucleus.
Synonyms: silent mating-type cassette heterochromatin organization; silent mating-type cassette heterochromatin spatial organization in the nucleus
iron-sulfur cluster export from the mitochondrion (GO:0140466)
Namespace: biological_process
Definition: The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane.
integrated stress response signaling (GO:0140467)
Namespace: biological_process
Definition: The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
Synonyms: ISR
HRI-mediated signaling (GO:0140468)
Namespace: biological_process
Definition: A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.
Synonyms: EIF2AK1-mediated signaling