LiteFold/GO huggingface dataset:
obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter (GO:1990652)
Namespace: biological_process
Definition: OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage.
Synonyms: positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete monounsaturated fatty acid biosynthetic process (GO:1990653)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of a monounsaturated fatty acid. A monounsaturated fatty acid has one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded, as opposed to polyunsaturated fatty acids.
Comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast.
sebum secreting cell proliferation (GO:1990654)
Namespace: biological_process
Definition: The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum.
Synonyms: sebocyte proliferation
4 iron, 3 sulfur cluster binding (GO:1990655)
Namespace: molecular_function
Definition: Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria.
Synonyms: 4Fe-3S cluster binding
t-SNARE clustering (GO:1990656)
Namespace: biological_process
Definition: The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies.
iNOS-S100A8/A9 complex (GO:1990657)
Namespace: cellular_component
Definition: A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine.
Comment: An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay).
transnitrosylase complex (GO:1990658)
Namespace: cellular_component
Definition: A transferase complex which is capable of transferring nitrogenous groups from one component to another.
Synonyms: transferase complex, transferring nitrogenous groups
Comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
obsolete sequestering of manganese ion (GO:1990659)
Namespace: biological_process
Definition: OBSOLETE. The process of binding or confining manganese ions such that they are separated from other components of a biological system.
Synonyms: manganese ion retention; manganese ion sequestering; manganese ion sequestration; manganese ion storage; retention of manganese ion; sequestration of manganese ion; storage of manganese ion
Comment: The reason for obsoletion is that this represents a molecular function, not a biological process.
calprotectin complex (GO:1990660)
Namespace: cellular_component
Definition: A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways.
Synonyms: calprotectin heterodimer
Comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
S100A8 complex (GO:1990661)
Namespace: cellular_component
Definition: A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4).
Synonyms: S100A8 homodimer
Comment: An example of this is S100A8 in human (UniProt symbol P27005) in PMID:25417112 (inferred from direct assay).
S100A9 complex (GO:1990662)
Namespace: cellular_component
Definition: A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility.
Synonyms: S100A9 homodimer
Comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay).
dihydroorotate dehydrogenase (fumarate) activity (GO:1990663)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate.
Nkx-2.5 complex (GO:1990664)
Namespace: cellular_component
Definition: A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes.
Synonyms: Nkx-2.5 homodimer complex; NKX.2-5 homodimer complex; NKX2.5 complex; NKX2E homodimer complex
Comment: An example of this is Nkx-2.5 in human (UniProt symbol P52952) in PMID:22849347 (inferred from direct assay).
AnxA2-p11 complex (GO:1990665)
Namespace: cellular_component
Definition: A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10).
Synonyms: (A2.p11)2 complex; (p11)2.(AnxA2)2 complex; Annexin A2 tetramer; Annexin A2-p11 complex; AnxA2.p11 complex; AnxA2:S100A10 heterotetramer
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane (GO:1990668)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles.
Synonyms: vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane; vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane; vesicle fusion with ER-Golgi intermediate compartment membrane; vesicle fusion with ERGIC membrane
endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane (GO:1990669)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
Synonyms: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane; ER-Golgi intermediate compartment derived vesicle fusion with ER membrane
vesicle fusion with Golgi cis cisterna membrane (GO:1990670)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles.
medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane (GO:1990672)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport.
obsolete intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane (GO:1990673)
Namespace: cellular_component
Definition: OBSOLETE. The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
Synonyms: intrinsic component of endoplasmic reticulum-Golgi intermediate compartment membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
Golgi cis cisterna membrane (GO:1990674)
Namespace: cellular_component
Definition: The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex.
Synonyms: cis-Golgi cisterna membrane; Golgi apparatus cis cisterna membrane
Golgi medial cisterna membrane (GO:1990675)
Namespace: cellular_component
Definition: The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex.
Synonyms: Golgi apparatus medial cisterna membrane; medial-Golgi cisterna membrane
Golgi trans cisterna membrane (GO:1990676)
Namespace: cellular_component
Definition: The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex.
Synonyms: trans-Golgi cisterna membrane
mitochondrial inner membrane assembly complex (GO:1990677)
Namespace: cellular_component
Definition: A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion.
Synonyms: INAC complex; inner membrane assembly complex; mitochondrion inner membrane assembly complex
Comment: An example of this is INA22 in Saccharomyces cerevisiae (P40576) in PMID:24942160 (inferred from direct assay/mutant phenotype/etc.).
obsolete histone H4-K16 deacetylation (GO:1990678)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H4-K12 deacetylation (GO:1990679)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
response to melanocyte-stimulating hormone (GO:1990680)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates.
Synonyms: response to MSH
CSF1-CSF1R complex (GO:1990682)
Namespace: cellular_component
Definition: A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.
Synonyms: CSF1:C-FMS complex; M-CSF:C-FMS complex; M-CSF:CSF1R complex; M-CSF:FMS complex; macrophage colony-stimulating factor:receptor complex
DNA double-strand break attachment to nuclear envelope (GO:1990683)
Namespace: biological_process
Definition: A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs.
protein-lipid-RNA complex (GO:1990684)
Namespace: cellular_component
Definition: A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other.
Synonyms: miRNA-lipoprotein complex
Comment: Examples of protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle' or GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs.
HDL-containing protein-lipid-RNA complex (GO:1990685)
Namespace: cellular_component
Definition: A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.
Comment: Examples of HDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoproteins (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle', which describes complexes of proteins and lipids only, without RNAs.
LDL-containing protein-lipid-RNA complex (GO:1990686)
Namespace: cellular_component
Definition: A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.
Comment: Examples of LDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs.
endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane (GO:1990687)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport.
Synonyms: ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane; ER-derived vesicle fusion with ERGIC membrane
Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane (GO:1990688)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
Synonyms: Golgi vesicle fusion with ER-Golgi intermediate compartment membrane; Golgi vesicle fusion with ERGIC membrane
endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane (GO:1990689)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport.
Synonyms: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane; ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane; ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane; ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane; ERGIC-derived vesicle fusion with Golgi cis cisterna membrane
Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane (GO:1990690)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
Synonyms: Golgi apparatus medial cisterna-derived vesicle fusion with Golgi apparatus cis cisterna membrane; medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane
cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane (GO:1990691)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport.
Synonyms: cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane
trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane (GO:1990692)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.
Synonyms: trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane
obsolete intrinsic component of Golgi cis cisterna membrane (GO:1990693)
Namespace: cellular_component
Definition: OBSOLETE. The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
Synonyms: intrinsic component of cis-Golgi cisterna membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete intrinsic component of Golgi medial cisterna membrane (GO:1990694)
Namespace: cellular_component
Definition: OBSOLETE. The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
Synonyms: intrinsic component of medial-Golgi cisterna membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete intrinsic component of Golgi trans cisterna membrane (GO:1990695)
Namespace: cellular_component
Definition: OBSOLETE. The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
Synonyms: intrinsic component of trans-Golgi cisterna membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
USH2 complex (GO:1990696)
Namespace: cellular_component
Definition: A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7.
Synonyms: USH2 quaternary protein complex
palmitoleoyltransferase activity (GO:1990698)
Namespace: molecular_function
Definition: Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule.
Comment: Note that this term should not be confused with 'palmitoyltransferase activity ; GO:0016409'.
palmitoleyl hydrolase activity (GO:1990699)
Namespace: molecular_function
Definition: Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate.
nucleolar chromatin organization (GO:1990700)
Namespace: biological_process
Definition: Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin.
Synonyms: establishment or maintenance of nucleolar chromatin architecture; nucleolar chromatin organisation
obsolete integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane (GO:1990701)
Namespace: cellular_component
Definition: OBSOLETE. The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral component of endoplasmic reticulum-Golgi intermediate compartment membrane; integral component of ER-Golgi intermediate compartment membrane; integral component of ERGIC membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of Golgi cis cisterna membrane (GO:1990702)
Namespace: cellular_component
Definition: OBSOLETE. The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral component of cis-Golgi cisterna membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of Golgi trans cisterna membrane (GO:1990704)
Namespace: cellular_component
Definition: OBSOLETE. The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral component of trans-Golgi cisterna membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
cholangiocyte proliferation (GO:1990705)
Namespace: biological_process
Definition: The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.
Synonyms: hepatoblast proliferation
conditioned place preference (GO:1990708)
Namespace: biological_process
Definition: The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug.
presynaptic active zone organization (GO:1990709)
Namespace: biological_process
Definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone.
Synonyms: presynaptic active zone organisation
MutS complex (GO:1990710)
Namespace: cellular_component
Definition: A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations.
Synonyms: MutS mismatch repair complex
Comment: An example of this is MutS in E. coli (UniProt symbol P23909) in PMID:21666597 (inferred from physical interaction).
beta-catenin-ICAT complex (GO:1990711)
Namespace: cellular_component
Definition: Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex.
Synonyms: CTNNB1-CTNNBIP1 complex
Comment: An example of this is Catenin beta-1 in human (UniProt symbol P35222) in PMID:12408824 (inferred from physical interaction).
HFE-transferrin receptor complex (GO:1990712)
Namespace: cellular_component
Definition: A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.