LiteFold/GO huggingface dataset:
taurine transmembrane transporter activity (GO:0005368)
Namespace: molecular_function
Definition: Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats.
taurine:sodium symporter activity (GO:0005369)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in).
Synonyms: sodium/chloride-dependent taurine transporter
tricarboxylate secondary active transmembrane transporter activity (GO:0005371)
Namespace: molecular_function
Definition: Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: tricarboxylate carrier activity
obsolete heavy metal ion porter activity (GO:0005373)
Namespace: molecular_function
Definition: OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane.
Synonyms: heavy metal ion porter activity; metal ion transporter
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
copper ion transmembrane transporter activity (GO:0005375)
Namespace: molecular_function
Definition: Enables the transfer of copper (Cu) ions from one side of a membrane to the other.
Synonyms: copper uptake transmembrane transporter activity; intracellular copper ion transporter; plasma membrane copper transporter
obsolete plasma membrane copper transporter (GO:0005376)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: plasma membrane copper transporter
Comment: This term was made obsolete because it contains both component and function information.
obsolete intracellular copper ion transporter (GO:0005377)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: intracellular copper ion transporter; intracellular copper transporter
Comment: This term was made obsolete because it contains both component and function information.
iron ion transmembrane transporter activity (GO:0005381)
Namespace: molecular_function
Definition: Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
Synonyms: iron cation channel activity; iron channel activity; iron transporter activity; multicopper ferroxidase iron transport mediator activity; transmembrane iron ion permease activity; transmembrane iron permease activity; zinc, iron permease activity
Comment: An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell.
manganese ion transmembrane transporter activity (GO:0005384)
Namespace: molecular_function
Definition: Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
zinc ion transmembrane transporter activity (GO:0005385)
Namespace: molecular_function
Definition: Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
Synonyms: cobalt, zinc uptake permease activity; zinc, cadmium uptake permease activity; zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity; zinc, iron permease activity
P-type calcium transporter activity (GO:0005388)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).
Synonyms: ATP-dependent calcium transmembrane transporter activity; ATPase-coupled calcium transmembrane transporter activity; Ca(2+)-transporting ATPase activity; Ca2+-transporting ATPase activity; calcium efflux ATPase; calcium pump; calcium transmembrane transporter activity, phosphorylative mechanism; calcium transporting ATPase activity; calcium-translocating P-type ATPase activity; calcium-transporting ATPase activity; sarco(endo)plasmic reticulum Ca2+-ATPase
P-type sodium:potassium-exchanging transporter activity (GO:0005391)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
Synonyms: Na(+)/K(+)-ATPase activity; Na(+)/K(+)-exchanging ATPase activity; Na+,K+-ATPase activity; Na+/K+-ATPase activity; Na+/K+-exchanging ATPase activity; Na,K-activated ATPase activity; P-type sodium:potassium-exchanging ATPase activity; sodium pump; sodium/potassium-exchanging ATPase activity; sodium/potassium-transporting ATPase activity; sodium:potassium exchanging ATPase activity; sodium:potassium-exchanging ATPase activity
obsolete eye pigment precursor transporter activity (GO:0005395)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out).
Comment: This term has been obsoleted because eye pigment precursors are nucleotides and amino acids, and there are terms to annotate these functions.
obsolete transmembrane conductance regulator activity (GO:0005396)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: transmembrane conductance regulator activity
Comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong.
obsolete peroxisomal membrane transporter (GO:0005400)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: peroxisomal membrane transporter
Comment: This term was made obsolete because it contains both component and function information.
carbohydrate:monoatomic cation symporter activity (GO:0005402)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in).
Synonyms: carbohydrate:cation symporter activity; cation/sugar symporter activity; cation:sugar symporter activity; sugar:cation symporter activity
D-glucose:sodium symporter activity (GO:0005412)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in).
Synonyms: glucose:sodium symporter activity; sodium/glucose symporter activity
nucleoside:sodium symporter activity (GO:0005415)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in).
Synonyms: nucleoside-sodium cotransporter activity; sodium-dependent nucleoside transporter activity
amino acid:monoatomic cation symporter activity (GO:0005416)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in).
Synonyms: amino acid:cation symporter activity; cation/amino acid symporter activity; cation:amino acid symporter activity
proton-dependent oligopeptide secondary active transmembrane transporter activity (GO:0005427)
Namespace: molecular_function
Definition: Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.
Synonyms: hydrogen/oligopeptide symporter; proton-dependent oligopeptide transporter activity
obsolete chromaffin granule amine transmembrane transporter activity (GO:0005429)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of amines across chromaffin granule membranes.
Comment: The term was obsoleted because its intended usage was unclear: chromaffin granules are dense core secretory vesicles (PMID:20853344) so whatever they transport must be by secretion.
sodium:phosphate symporter activity (GO:0005436)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).
Synonyms: sodium-dependent phosphate transmembrane transporter activity; sodium/phosphate symporter activity
obsolete monoatomic cation:proton antiporter activity (GO:0005451)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + H+(in) = monoatomic cation(in) + H+(out).
Synonyms: monovalent cation:hydrogen antiporter activity; monovalent cation:proton antiporter activity
Comment: This term was obsoleted because it represents an unnecessary grouping term.
solute:inorganic anion antiporter activity (GO:0005452)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).
Synonyms: inorganic anion exchanger activity
CMP-N-acetylneuraminate transmembrane transporter activity (GO:0005456)
Namespace: molecular_function
Definition: Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other.
Synonyms: CMP-sialic acid transmembrane transporter activity
GDP-fucose transmembrane transporter activity (GO:0005457)
Namespace: molecular_function
Definition: Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.
GDP-mannose transmembrane transporter activity (GO:0005458)
Namespace: molecular_function
Definition: Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate.
UDP-galactose transmembrane transporter activity (GO:0005459)
Namespace: molecular_function
Definition: Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.
UDP-glucose transmembrane transporter activity (GO:0005460)
Namespace: molecular_function
Definition: Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate.
UDP-glucuronate transmembrane transporter activity (GO:0005461)
Namespace: molecular_function
Definition: Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.
Synonyms: UDP-glucuronic acid transmembrane transporter activity
UDP-N-acetylglucosamine transmembrane transporter activity (GO:0005462)
Namespace: molecular_function
Definition: Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.
UDP-N-acetylgalactosamine transmembrane transporter activity (GO:0005463)
Namespace: molecular_function
Definition: Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.
UDP-xylose transmembrane transporter activity (GO:0005464)
Namespace: molecular_function
Definition: Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate.
obsolete small-molecule carrier or transporter (GO:0005468)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: small-molecule carrier or transporter
Comment: This term was made obsolete because it does not provide a useful functional classification.
succinate:fumarate antiporter activity (GO:0005469)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out).
ATP:ADP antiporter activity (GO:0005471)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out).
Synonyms: adenine nucleotide translocase; ADP/ATP carrier protein; ADP/ATP translocase; ATP/ADP exchange; ATP/ADP exchanger
carnitine:O-acyl-L-carnitine antiporter activity (GO:0005476)
Namespace: molecular_function
Definition: Catalysis of the reaction: carnitine (mitochondrial) + O-acyl-L-carnitine (cytoplasm) = carnitine (cytoplasm) + O-acyl-L-carnitine (mitochondrial).
Synonyms: carnitine/acyl carnitine carrier activity; carnitine:acyl carnitine carrier activity; fatty acyl carnitine carrier
obsolete vacuolar assembly (GO:0005479)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: vacuolar assembly
Comment: This term was made obsolete because it represents a biological process and not a molecular function.
obsolete vesicle fusion (GO:0005481)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: vesicle fusion
Comment: This term was made obsolete because it represents a biological process and not a molecular function.
obsolete vesicle targeting (GO:0005482)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: vesicle targeting
Comment: This term was made obsolete because it represents a biological process and not a molecular function.
soluble NSF attachment protein activity (GO:0005483)
Namespace: molecular_function
Definition: Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex.
Synonyms: SNAP
SNAP receptor activity (GO:0005484)
Namespace: molecular_function
Definition: Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
Synonyms: Q-SNARE activity; R-SNARE activity; SNAP-25; SNARE; t-SNARE activity; v-SNARE activity
binding (GO:0005488)
Namespace: molecular_function
Definition: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
Synonyms: ligand
obsolete electron transporter activity (GO:0005489)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells.
Synonyms: class I cytochrome c; class II cytochrome c; class IIa cytochrome c; class IIb cytochrome c; class III cytochrome c; class IV cytochrome c; cytochrome b; cytochrome b5; cytochrome c3 (tetraheme); cytochrome c554; cytochrome c7 (triheme); cytochrome d; diheme class I cytochrome c; electron transfer carrier; electron transporter activity; flavin-containing electron transporter; flavodoxin; high-molecular-weight cytochrome c (hexadecaheme); monoheme class I cytochrome c; nonaheme cytochrome c; respiratory chain cytochrome b6; Rieske iron-sulfur protein
Comment: This term was made obsolete because the activity described by the definition does not exist.
obsolete cytochrome P450 (GO:0005490)
Namespace: molecular_function
Definition: OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates.
Synonyms: cytochrome P450
Comment: This term was made obsolete because its definition was changed and because it represents a gene product.
steroid binding (GO:0005496)
Namespace: molecular_function
Definition: Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
androgen binding (GO:0005497)
Namespace: molecular_function
Definition: Binding to an androgen, a male sex hormone.
vitamin D binding (GO:0005499)
Namespace: molecular_function
Definition: Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
Synonyms: calciferol binding; cholecalciferol binding; ergocalciferol binding
juvenile hormone binding (GO:0005500)
Namespace: molecular_function
Definition: Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.
retinoid binding (GO:0005501)
Namespace: molecular_function
Definition: Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
11-cis retinal binding (GO:0005502)
Namespace: molecular_function
Definition: Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A.
Synonyms: 11-cis retinaldehyde binding; 11-cis-retinal binding; vitamin A binding
all-trans retinal binding (GO:0005503)
Namespace: molecular_function
Definition: Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A.
Synonyms: all-trans retinaldehyde binding; trans retinal binding; visual yellow binding; vitamin A binding; xanthopsin
fatty acid binding (GO:0005504)
Namespace: molecular_function
Definition: Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
obsolete heavy metal binding (GO:0005505)
Namespace: molecular_function
Definition: OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn.
Synonyms: heavy metal binding
Comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
copper ion binding (GO:0005507)
Namespace: molecular_function
Definition: Binding to a copper (Cu) ion.
Synonyms: copper binding; copper/cadmium binding
obsolete copper/cadmium binding (GO:0005508)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: copper/cadmium binding
Comment: This term was made obsolete because it represents a composite function.
calcium ion binding (GO:0005509)
Namespace: molecular_function
Definition: Binding to a calcium ion (Ca2+).
Synonyms: calcium ion storage activity
detection of calcium ion (GO:0005513)
Namespace: biological_process
Definition: The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
Synonyms: Ca2+ ion detection; calcium ion detection; calcium ion sensing; detection of Ca2+ ion
obsolete calcium ion storage activity (GO:0005514)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: calcium ion storage activity
Comment: This term was made obsolete because it represents a biological process.
protein binding (GO:0005515)
Namespace: molecular_function
Definition: Binding to a protein.
Synonyms: glycoprotein binding; protein amino acid binding
calmodulin binding (GO:0005516)
Namespace: molecular_function
Definition: Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
obsolete calmodulin inhibitor activity (GO:0005517)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: calmodulin inhibitor activity
Comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'.
collagen binding (GO:0005518)
Namespace: molecular_function
Definition: Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
cytoskeletal regulatory protein binding (GO:0005519)
Namespace: molecular_function
Definition: Binding to a protein involved in modulating the reorganization of the cytoskeleton.
lamin binding (GO:0005521)
Namespace: molecular_function
Definition: Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.
Synonyms: lamin/chromatin binding
profilin binding (GO:0005522)
Namespace: molecular_function
Definition: Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.
tropomyosin binding (GO:0005523)
Namespace: molecular_function
Definition: Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
macrolide binding (GO:0005527)
Namespace: molecular_function
Definition: Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species.
FK506 binding (GO:0005528)
Namespace: molecular_function
Definition: Binding to a 23-membered macrolide lactone FK506.
Synonyms: FK506-sensitive peptidyl-prolyl cis-trans isomerase
obsolete lectin (GO:0005530)
Namespace: molecular_function
Definition: OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell.
Synonyms: lectin
Comment: This term was made obsolete because it refers to a class of gene products.
obsolete galactose binding lectin (GO:0005531)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: galactose binding lectin
Comment: This term was made obsolete because it refers to a class of gene products.
obsolete mannose binding lectin (GO:0005532)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: mannose binding lectin; mannose receptor
Comment: This term was made obsolete because it refers to a class of gene products.