LiteFold/GO huggingface dataset:
midbody (GO:0030496)
Namespace: cellular_component
Definition: A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
fatty acid elongation (GO:0030497)
Namespace: biological_process
Definition: The elongation of a fatty acid chain by the sequential addition of two-carbon units.
regulation of bone mineralization (GO:0030500)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of bone mineralization.
positive regulation of bone mineralization (GO:0030501)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of bone mineralization.
Synonyms: activation of bone mineralization; stimulation of bone mineralization; up regulation of bone mineralization; up-regulation of bone mineralization; upregulation of bone mineralization
obsolete inorganic diphosphate transmembrane transporter activity (GO:0030504)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of inorganic diphosphate across a membrane.
Synonyms: inorganic pyrophosphate transporter activity
Comment: The reason for obsoletion is that this term was an unnecessary and confusing grouping term.
inorganic diphosphate transport (GO:0030505)
Namespace: biological_process
Definition: The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: inorganic pyrophosphate transport
ankyrin binding (GO:0030506)
Namespace: molecular_function
Definition: Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
spectrin binding (GO:0030507)
Namespace: molecular_function
Definition: Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
obsolete thiol-disulfide exchange intermediate activity (GO:0030508)
Namespace: molecular_function
Definition: OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions.
Synonyms: glutaredoxin; thiol-disulfide exchange intermediate activity; thiol-disulphide exchange intermediate activity; thioredoxin
Comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process.
BMP signaling pathway (GO:0030509)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: BMP receptor signaling pathway; BMP signalling pathway; bone morphogenetic protein signaling pathway; bone morphogenetic protein signalling pathway; decapentaplegic receptor signaling pathway; decapentaplegic receptor signalling pathway; decapentaplegic signaling pathway; dpp receptor signaling pathway; dpp receptor signalling pathway; dpp signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
Synonyms: activation of transforming growth factor beta receptor signaling pathway; positive regulation of TGF-beta receptor signaling pathway; positive regulation of TGFbeta receptor signaling pathway; positive regulation of transforming growth factor beta receptor signalling pathway; stimulation of transforming growth factor beta receptor signaling pathway; up regulation of transforming growth factor beta receptor signaling pathway; up-regulation of transforming growth factor beta receptor signaling pathway; upregulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
Synonyms: down regulation of transforming growth factor beta receptor signaling pathway; down-regulation of transforming growth factor beta receptor signaling pathway; downregulation of transforming growth factor beta receptor signaling pathway; inhibition of transforming growth factor beta receptor signaling pathway; negative regulation of TGF-beta receptor signaling pathway; negative regulation of TGFbeta receptor signaling pathway; negative regulation of transforming growth factor beta receptor signalling pathway
positive regulation of BMP signaling pathway (GO:0030513)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
Synonyms: activation of BMP signaling pathway; positive regulation of BMP receptor signaling pathway; positive regulation of BMP signalling pathway; positive regulation of bone morphogenetic protein signaling pathway; positive regulation of bone morphogenetic protein signalling pathway; positive regulation of decapentaplegic receptor signaling pathway; positive regulation of decapentaplegic receptor signalling pathway; positive regulation of decapentaplegic signaling pathway; stimulation of BMP signaling pathway; up regulation of BMP signaling pathway; up-regulation of BMP signaling pathway; upregulation of BMP signaling pathway
negative regulation of BMP signaling pathway (GO:0030514)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
Synonyms: down regulation of BMP signaling pathway; down-regulation of BMP signaling pathway; downregulation of BMP signaling pathway; inhibition of BMP signaling pathway; negative regulation of BMP receptor signaling pathway; negative regulation of BMP signalling pathway; negative regulation of bone morphogenetic protein signaling pathway; negative regulation of bone morphogenetic protein signalling pathway; negative regulation of decapentaplegic receptor signaling pathway; negative regulation of decapentaplegic receptor signalling pathway; negative regulation of decapentaplegic signaling pathway
snoRNA binding (GO:0030515)
Namespace: molecular_function
Definition: Binding to a small nucleolar RNA.
regulation of axon extension (GO:0030516)
Namespace: biological_process
Definition: Any process that modulates the rate, direction or extent of axon extension.
negative regulation of axon extension (GO:0030517)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
Synonyms: down regulation of axon extension; down-regulation of axon extension; downregulation of axon extension; inhibition of axon extension
snoRNP binding (GO:0030519)
Namespace: molecular_function
Definition: Binding to a small nucleolar ribonucleoprotein particle.
estrogen receptor signaling pathway (GO:0030520)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: estrogen receptor signalling pathway; intracellular estrogen receptor signaling pathway; nuclear receptor-mediated estrogen signaling pathway
androgen receptor signaling pathway (GO:0030521)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by an androgen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: androgen receptor signalling pathway; nuclear-receptor-mediated androgen receptor signaling pathway
intracellular receptor signaling pathway (GO:0030522)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a receptor located within a cell.
Synonyms: intracellular receptor mediated signaling pathway; intracellular receptor-mediated signaling pathway; intracellular receptor-mediated signalling pathway
granulocyte macrophage colony-stimulating factor receptor complex (GO:0030526)
Namespace: cellular_component
Definition: The heterodimeric receptor for granulocyte macrophage colony-stimulating factor.
Synonyms: GM-CSF receptor complex; granulocyte macrophage colony stimulating factor receptor complex
structural constituent of chromatin (GO:0030527)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of chromatin.
obsolete transcription regulator activity (GO:0030528)
Namespace: molecular_function
Definition: OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor.
Synonyms: transcription regulator activity; transcriptional regulator activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
obsolete heterogeneous nuclear ribonucleoprotein complex (GO:0030530)
Namespace: cellular_component
Definition: OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA.
Synonyms: heterogeneous nuclear ribonucleoprotein; heterogeneous nuclear ribonucleoprotein complex; hnRNP
Comment: This term was made because heterogeneous nuclear ribonucleoprotein is an experimental construct and does not correspond cleanly to a functional cellular entity.
obsolete small cytoplasmic ribonucleoprotein complex (GO:0030531)
Namespace: cellular_component
Definition: OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm.
Synonyms: scRNP; small cytoplasmic ribonucleoprotein; small cytoplasmic ribonucleoprotein complex
Comment: This term was made obsolete because it was not clearly defined.
small nuclear ribonucleoprotein complex (GO:0030532)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs.
Synonyms: small nuclear ribonucleoprotein; snRNP
triplet codon-amino acid adaptor activity (GO:0030533)
Namespace: molecular_function
Definition: The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.
Synonyms: transfer RNA; tRNA
Comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.
adult behavior (GO:0030534)
Namespace: biological_process
Definition: Behavior in a fully developed and mature organism.
Synonyms: adult behavioral response to stimulus; adult behaviour; adult behavioural response to stimulus
Comment: See also the biological process term 'behavior ; GO:0007610'.
obsolete adult feeding behavior (sensu Insecta) (GO:0030535)
Namespace: biological_process
Definition: OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects.
Synonyms: adult feeding behavior (sensu Insecta)
Comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
larval feeding behavior (GO:0030536)
Namespace: biological_process
Definition: Feeding behavior in a larval (immature) organism.
Synonyms: larval feeding behaviour
Comment: See also the biological process term 'feeding behavior ; GO:0007631'.
larval behavior (GO:0030537)
Namespace: biological_process
Definition: Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics.
Synonyms: larval behaviour
Comment: See also the biological process term 'behavior ; GO:0007610'.
embryonic genitalia morphogenesis (GO:0030538)
Namespace: biological_process
Definition: The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized.
Synonyms: embryonic genital morphogenesis
male genitalia development (GO:0030539)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
Synonyms: male genital development
plasmid partitioning (GO:0030541)
Namespace: biological_process
Definition: Any process in which plasmids are segregated or distributed into daughter cells upon cell division.
2-micrometer plasmid partitioning (GO:0030543)
Namespace: biological_process
Definition: The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division.
Hsp70 protein binding (GO:0030544)
Namespace: molecular_function
Definition: Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
signaling receptor regulator activity (GO:0030545)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a receptor.
Synonyms: receptor regulator activity
signaling receptor activator activity (GO:0030546)
Namespace: molecular_function
Definition: The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.
Synonyms: receptor activator activity; signalling receptor activator activity
signaling receptor inhibitor activity (GO:0030547)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a signaling receptor.
Synonyms: receptor inhibitor activity
acetylcholine receptor regulator activity (GO:0030548)
Namespace: molecular_function
Definition: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.
acetylcholine receptor activator activity (GO:0030549)
Namespace: molecular_function
Definition: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.
cyclic nucleotide binding (GO:0030551)
Namespace: molecular_function
Definition: Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
cAMP binding (GO:0030552)
Namespace: molecular_function
Definition: Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
Synonyms: 3',5' cAMP binding; 3',5'-cAMP binding; adenosine 3',5'-cyclophosphate binding; cyclic AMP binding
adenyl nucleotide binding (GO:0030554)
Namespace: molecular_function
Definition: Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate.
RNA modification guide activity (GO:0030555)
Namespace: molecular_function
Definition: Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
rRNA modification guide activity (GO:0030556)
Namespace: molecular_function
Definition: Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
tRNA modification guide activity (GO:0030557)
Namespace: molecular_function
Definition: Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
RNA pseudouridylation guide activity (GO:0030558)
Namespace: molecular_function
Definition: Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
rRNA pseudouridylation guide activity (GO:0030559)
Namespace: molecular_function
Definition: Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
tRNA pseudouridylation guide activity (GO:0030560)
Namespace: molecular_function
Definition: Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
RNA 2'-O-ribose methylation guide activity (GO:0030561)
Namespace: molecular_function
Definition: Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
rRNA 2'-O-ribose methylation guide activity (GO:0030562)
Namespace: molecular_function
Definition: Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
snRNA 2'-O-ribose methylation guide activity (GO:0030563)
Namespace: molecular_function
Definition: Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
tRNA 2'-O-ribose methylation guide activity (GO:0030564)
Namespace: molecular_function
Definition: Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
obsolete thrombin activator activity (GO:0030567)
Namespace: molecular_function
Definition: OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin.
Synonyms: prothrombin activator activity; thrombin activator activity
Comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
obsolete plasmin inhibitor activity (GO:0030568)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin.
Synonyms: plasmin inhibitor activity
Comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
pectate lyase activity (GO:0030570)
Namespace: molecular_function
Definition: Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends.
Synonyms: (1->4)-alpha-D-galacturonan lyase activity; alpha-1,4-D-endopolygalacturonic acid lyase activity; endo-alpha-1,4-polygalacturonic acid lyase activity; endogalacturonate transeliminase activity; endopectin methyltranseliminase activity; pectate transeliminase activity; pectic acid lyase activity; pectic acid transeliminase activity; pectic lyase activity; pectin trans-eliminase activity; PGA lyase activity; polygalacturonate lyase activity; polygalacturonic acid lyase activity; polygalacturonic acid trans-eliminase activity; polygalacturonic transeliminase activity; PPase-N activity
phosphatidyltransferase activity (GO:0030572)
Namespace: molecular_function
Definition: Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group.
bile acid catabolic process (GO:0030573)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.
Synonyms: bile acid 7alpha-dehydroxylation pathway; bile acid breakdown; bile acid catabolism; bile acid degradation; cholate catabolic process
collagen catabolic process (GO:0030574)
Namespace: biological_process
Definition: The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.
Synonyms: collagen breakdown; collagen catabolism; collagen degradation