LiteFold/GO huggingface dataset:
MHC class II protein binding, via antigen binding groove (GO:0042658)
Namespace: molecular_function
Definition: Binding to the antigen binding groove of major histocompatibility complex class II molecules.
Synonyms: major histocompatibility complex class II protein binding, via antigen binding groove
regulation of cell fate specification (GO:0042659)
Namespace: biological_process
Definition: Any process that mediates the adoption of a specific fate by a cell.
positive regulation of cell fate specification (GO:0042660)
Namespace: biological_process
Definition: Any process that activates or enables a cell to adopt a specific fate.
Synonyms: activation of cell fate specification; stimulation of cell fate specification; up regulation of cell fate specification; up-regulation of cell fate specification; upregulation of cell fate specification
regulation of mesodermal cell fate specification (GO:0042661)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.
negative regulation of mesodermal cell fate specification (GO:0042662)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.
Synonyms: down regulation of mesodermal cell fate specification; down-regulation of mesodermal cell fate specification; downregulation of mesodermal cell fate specification; inhibition of mesodermal cell fate specification; suppression of mesodermal cell fate
regulation of endodermal cell fate specification (GO:0042663)
Namespace: biological_process
Definition: Any process that mediates the specification of a cell into an endoderm cell.
Synonyms: regulation of endoderm cell fate specification
negative regulation of endodermal cell fate specification (GO:0042664)
Namespace: biological_process
Definition: Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.
Synonyms: down regulation of endodermal cell fate specification; down-regulation of endodermal cell fate specification; downregulation of endodermal cell fate specification; inhibition of endodermal cell fate specification; negative regulation of endoderm cell fate specification; suppression of endoderm cell fate; suppression of endodermal cell fate
negative regulation of ectodermal cell fate specification (GO:0042666)
Namespace: biological_process
Definition: Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.
Synonyms: down regulation of ectodermal cell fate specification; down-regulation of ectodermal cell fate specification; downregulation of ectodermal cell fate specification; inhibition of ectodermal cell fate specification; negative regulation of ectoderm cell fate specification; suppression of ectoderm cell fate; suppression of ectodermal cell fate
auditory receptor cell fate specification (GO:0042667)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Synonyms: auditory hair cell fate specification
auditory receptor cell fate determination (GO:0042668)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed.
Synonyms: auditory hair cell fate determination
regulation of inner ear auditory receptor cell fate specification (GO:0042669)
Namespace: biological_process
Definition: Any process that mediates the specification of a cell into an auditory hair cell.
Synonyms: regulation of auditory hair cell fate specification
retinal cone cell differentiation (GO:0042670)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.
retinal cone cell fate determination (GO:0042671)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed.
retinal cone cell fate specification (GO:0042672)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
compound eye cone cell differentiation (GO:0042675)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye.
compound eye cone cell fate commitment (GO:0042676)
Namespace: biological_process
Definition: The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type.
compound eye cone cell fate specification (GO:0042679)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
compound eye cone cell fate determination (GO:0042680)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed.
regulation of compound eye cone cell fate specification (GO:0042682)
Namespace: biological_process
Definition: Any process that mediates the specification of a cell into a compound eye cone cell.
negative regulation of compound eye cone cell fate specification (GO:0042683)
Namespace: biological_process
Definition: Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell.
Synonyms: down regulation of cone cell fate specification; down-regulation of cone cell fate specification; downregulation of cone cell fate specification; inhibition of cone cell fate specification; suppression of cone cell fate
cardioblast cell fate commitment (GO:0042684)
Namespace: biological_process
Definition: The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
cardioblast cell fate specification (GO:0042685)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
regulation of cardioblast cell fate specification (GO:0042686)
Namespace: biological_process
Definition: Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
regulation of crystal cell differentiation (GO:0042689)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of crystal cell differentiation.
negative regulation of crystal cell differentiation (GO:0042690)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation.
Synonyms: down regulation of crystal cell differentiation; down-regulation of crystal cell differentiation; downregulation of crystal cell differentiation; inhibition of crystal cell differentiation
positive regulation of crystal cell differentiation (GO:0042691)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of crystal cell differentiation.
Synonyms: activation of crystal cell differentiation; stimulation of crystal cell differentiation; up regulation of crystal cell differentiation; up-regulation of crystal cell differentiation; upregulation of crystal cell differentiation
muscle cell differentiation (GO:0042692)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.
Synonyms: myogenesis
muscle cell fate commitment (GO:0042693)
Namespace: biological_process
Definition: The process in which the cellular identity of muscle cells is acquired and determined.
muscle cell fate specification (GO:0042694)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
thelarche (GO:0042695)
Namespace: biological_process
Definition: The beginning of development of the breasts in the female.
menarche (GO:0042696)
Namespace: biological_process
Definition: The beginning of the menstrual cycle; the first menstrual cycle in an individual.
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
menopause (GO:0042697)
Namespace: biological_process
Definition: Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50.
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
follicle-stimulating hormone signaling pathway (GO:0042699)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by follicle-stimulating hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: follicle stimulating hormone signaling pathway; follicle stimulating hormone signalling pathway; follicle-stimulating hormone signalling pathway
luteinizing hormone signaling pathway (GO:0042700)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by luteinizing hormone binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: luteinizing hormone signalling pathway
progesterone secretion (GO:0042701)
Namespace: biological_process
Definition: The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta.
uterine wall growth (GO:0042702)
Namespace: biological_process
Definition: The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels.
menstruation (GO:0042703)
Namespace: biological_process
Definition: The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
uterine wall breakdown (GO:0042704)
Namespace: biological_process
Definition: The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels.
ocellus photoreceptor cell differentiation (GO:0042705)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus.
eye photoreceptor cell fate commitment (GO:0042706)
Namespace: biological_process
Definition: The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.
ocellus photoreceptor cell fate commitment (GO:0042707)
Namespace: biological_process
Definition: The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.
obsolete elastase activity (GO:0042708)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of elastin.
Synonyms: elastase activity
Comment: This term was made obsolete because it represents a gene product.
succinate-CoA ligase complex (GO:0042709)
Namespace: cellular_component
Definition: A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.
biofilm formation (GO:0042710)
Namespace: biological_process
Definition: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
maternal behavior (GO:0042711)
Namespace: biological_process
Definition: Female behaviors associated with the care and rearing of offspring.
Synonyms: maternal behaviour
paternal behavior (GO:0042712)
Namespace: biological_process
Definition: Male behaviors associated with the care and rearing offspring.
Synonyms: paternal behaviour
sperm ejaculation (GO:0042713)
Namespace: biological_process
Definition: The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.
obsolete dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome (GO:0042715)
Namespace: biological_process
Definition: OBSOLETE. The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans.
Synonyms: dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome
Comment: The reason for obsoletion is that this represents a GO-CAM model.
plasma membrane-derived chromatophore (GO:0042716)
Namespace: cellular_component
Definition: A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria.
Synonyms: chromatophore vesicle
Comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin.
plasma membrane-derived chromatophore membrane (GO:0042717)
Namespace: cellular_component
Definition: The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles.
yolk granule (GO:0042718)
Namespace: cellular_component
Definition: Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed.
mitochondrial intermembrane space chaperone complex (GO:0042719)
Namespace: cellular_component
Definition: mitochondrial protein-containing complex localised in the mitochondrial inner membrane space that chaperones proteins to the TIM22 complex for insertion into the mitochondrial inner membrane.
Synonyms: mitochondrial intermembrane space protein transporter complex; small TIM complex; Tim8-Tim13 complex; Tim9-Tim10 complex
mitochondrial inner membrane peptidase complex (GO:0042720)
Namespace: cellular_component
Definition: Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space.
Synonyms: IMP; mitochondrion inner membrane peptidase complex
TIM22 mitochondrial import inner membrane insertion complex (GO:0042721)
Namespace: cellular_component
Definition: A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.
Synonyms: mitochondrial inner membrane protein insertion complex; mitochondrial protein translocase complex; Tim22 complex
alpha-beta T cell activation by superantigen (GO:0042722)
Namespace: biological_process
Definition: The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region.
Synonyms: alpha-beta T lymphocyte activation by superantigen; alpha-beta T-cell activation by superantigen; alpha-beta T-lymphocyte activation by superantigen
thiamine-containing compound metabolic process (GO:0042723)
Namespace: biological_process
Definition: The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.
Synonyms: thiamin and derivative metabolic process; thiamin and derivative metabolism; thiamin-containing compound metabolic process; thiamine and derivative metabolic process; thiamine and derivative metabolism; thiamine-containing compound metabolism; vitamin B1 and derivative metabolic process; vitamin B1 and derivative metabolism
thiamine-containing compound biosynthetic process (GO:0042724)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds.
Synonyms: thiamin and derivative biosynthesis; thiamin and derivative biosynthetic process; thiamin-containing compound biosynthetic process; thiamine and derivative biosynthesis; thiamine and derivative biosynthetic process; thiamine-containing compound anabolism; thiamine-containing compound biosynthesis; thiamine-containing compound formation; thiamine-containing compound synthesis; vitamin B1 and derivative biosynthesis; vitamin B1 and derivative biosynthetic process
thiamine-containing compound catabolic process (GO:0042725)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it.
Synonyms: thiamin and derivative catabolic process; thiamin and derivative catabolism; thiamin-containing compound catabolic process; thiamine and derivative catabolic process; thiamine and derivative catabolism; thiamine-containing compound breakdown; thiamine-containing compound catabolism; thiamine-containing compound degradation; vitamin B1 and derivative catabolic process; vitamin B1 and derivative catabolism
flavin-containing compound metabolic process (GO:0042726)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.
Synonyms: flavin-containing compound metabolism; riboflavin and derivative metabolic process; riboflavin and derivative metabolism; vitamin B2 and derivative metabolic process; vitamin B2 and derivative metabolism
flavin-containing compound catabolic process (GO:0042728)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.
Synonyms: flavin-containing compound catabolic process breakdown; flavin-containing compound catabolic process degradation; flavin-containing compound catabolism; riboflavin and derivative catabolic process; riboflavin and derivative catabolism; vitamin B2 and derivative catabolic process; vitamin B2 and derivative catabolism
fibrinolysis (GO:0042730)
Namespace: biological_process
Definition: A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
PH domain binding (GO:0042731)
Namespace: molecular_function
Definition: Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
D-xylose metabolic process (GO:0042732)
Namespace: biological_process
Definition: The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.
Synonyms: D-xylose metabolism
embryonic digit morphogenesis (GO:0042733)
Namespace: biological_process
Definition: The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
presynaptic membrane (GO:0042734)
Namespace: cellular_component
Definition: A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
Synonyms: pre-synaptic membrane; presynaptic plasma membrane
endosperm protein body (GO:0042735)
Namespace: cellular_component
Definition: A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins.
NADH kinase activity (GO:0042736)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + NADH = ADP + 2 H+ + NADPH.
Synonyms: ATP:NADH 2'-phosphotransferase activity; DPNH kinase activity; reduced diphosphopyridine nucleotide kinase activity; reduced nicotinamide adenine dinucleotide kinase (phosphorylating)