LiteFold/GO huggingface dataset:
structural constituent of nuclear lamina (GO:0160123)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of nuclear lamina.
guanyl nucleotide exchange factor activator activity (GO:0160124)
Namespace: molecular_function
Definition: Binds to and increases the activity of a guanyl nucleotide exchange factor.
pH-gated sodium channel activity (GO:0160125)
Namespace: molecular_function
Definition: A gated channel activity that enables the transmembrane transfer of a sodium ion by a channel that opens in response to a change in pH.
Synonyms: pH-dependent sodium channel activity; pH-sensitive sodium channel activity
pH-gated calcium channel activity (GO:0160126)
Namespace: molecular_function
Definition: A gated channel activity that enables the transmembrane transfer of a calcium ion by a channel that opens in response to a change in pH.
Synonyms: pH-dependent calcium channel activity; pH-sensitive calcium channel activity
protein-RNA covalent cross-linking repair (GO:0160127)
Namespace: biological_process
Definition: A process that rescues stalled ribosomes by removing the covalent cross-link between RNA and a protein.
pH-gated monoatomic ion channel activity (GO:0160128)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH).
Synonyms: acid-sensing ion channel activity; proton-gated ion channel activity
Comment: While the term suggest this activity may be proton-gated, the mechanism of pH-gating for transporters is by protonation of specific residues in the protein, and not by H+ binding.
protein-DNA covalent cross-linking activity (GO:0160129)
Namespace: molecular_function
Definition: Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein.
sperm migration through the uterotubal junction (GO:0160131)
Namespace: biological_process
Definition: The controlled self-propelled movement of a sperm cell from the uterus through the uterotubal junction (UTJ) into the oviduct, where interaction between the sperm and the UTJ acts as a major selective barrier for sperm, allowing only living, motile, uncapacitated, morphologically normal sperm with intact acrosomes to pass from the uterus into the oviduct.
Synonyms: sperm migration from the uterus to the oviduct; sperm migration through the UTJ
meisosome (GO:0160132)
Namespace: cellular_component
Definition: A cell part that is composed of multifold plasma membrane of the epidermis where it is in direct contact with apical extracellular matrix. Meisosome, or multiple eisome is named because of its superficial similarity to yeast eisosome.
bicarbonate channel activity (GO:0160133)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of bicarbonate through a transmembrane aqueous pore or channel.
Synonyms: hydrogencarbonate channel activity
protein-RNA sequence-specific adaptor activity (GO:0160134)
Namespace: molecular_function
Definition: A protein adaptor activity characterized by the capacity to selectively recognize and interact with RNA molecules in a sequence-specific manner. Entities possessing this activity typically exhibit discerning binding preferences for specific nucleotide sequences within RNA molecules, enabling the identification and engagement of distinct RNA motifs or structural elements. This function is integral to various biological processes, including RNA processing, transport, and regulatory mechanisms, contributing to the specificity and precision of cellular RNA-related activities.
phospholipase C-activating endothelin receptor signaling pathway (GO:0160135)
Namespace: biological_process
Definition: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
16S rRNA pseudouridine(516) synthase activity (GO:0160136)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA.
23S rRNA pseudouridine(2457) synthase activity (GO:0160137)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA.
23S rRNA pseudouridine(2604) synthase activity (GO:0160138)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA.
23S rRNA pseudouridine(1911/1915/1917) synthase activity (GO:0160140)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA.
23S rRNA pseudouridine(955/2504/2580) synthase activity (GO:0160141)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA.
23S rRNA pseudouridine(746) synthase activity (GO:0160142)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA.
21S rRNA pseudouridine(2819) synthase activity (GO:0160143)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA.
GDF15-GFRAL signaling pathway (GO:0160144)
Namespace: biological_process
Definition: The series of molecular signals initiated by GDF15 binding to GFRAL coreceptor, triggering RET autophosphorylation and activation, in response to stress.
negative regulation of GDF15-GFRAL signaling pathway (GO:0160145)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of GDF15-GFRAL signaling pathway.
tRNA pseudouridine(38-40) synthase activity (GO:0160147)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA. Modifies uridine(38), uridine(39) and/or uridine(40) in tRNA.
Synonyms: PSUI activity; tRNA pseudouridylate synthase
tRNA pseudouridine(55) synthase activity (GO:0160148)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(55) in tRNA = pseudouridine(55) in tRNA.
tRNA pseudouridine(65) synthase activity (GO:0160149)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(65) in tRNA = pseudouridine(65) in tRNA.
tRNA pseudouridine(13) synthase activity (GO:0160150)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(13) in tRNA = pseudouridine(13) in tRNA.
tRNA pseudouridine(32) synthase activity (GO:0160151)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(32) in tRNA = pseudouridine(32) in tRNA.
tRNA pseudouridine(31) synthase activity (GO:0160152)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(31) in tRNA = pseudouridine(31) in tRNA.
tRNA pseudouridine(38/39) synthase activity (GO:0160154)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA. Modifies uridine(38) and/or uridine(39) in tRNA.
crinophagy (GO:0160155)
Namespace: biological_process
Definition: The autophagic process which involves the direct fusion of abnormal, excess or obsolete secretory granules with lysosomes. This pathway is often associated with maintaining homeostasis in endocrine and exocrine cells.
secretory granule-lysosome fusion (GO:0160156)
Namespace: biological_process
Definition: The cellular process that results in the fusion of secretory granules with lysosomes to form crinosomes.
branched-chain alpha-ketoacid dehydrogenase complex (GO:0160157)
Namespace: cellular_component
Definition: A multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: branched-chain alpha-ketoacid dehydrogenase (E1, a heterotetramer of two alpha and two beta subunits), dihydrolipoyl transacylase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
Synonyms: BCKD complex; BKDH complex
Comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms '3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity ; GO:0003863' (E1), 'dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity ; GO:0043754' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3).
obsolete cytosolic branched-chain alpha-keto acid dehydrogenase complex (GO:0160158)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex that catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. It is composed of four polypeptides, E1alpha, E1beta, E2, and E3.
Synonyms: BKDH complex
Comment: This term is unnecessarily taxon-specific.
positive regulation of N-acetylmuramic acid catabolic process (GO:0160159)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of N-acetylmuramic acid catabolic process.
positive regulation of nicotine catabolic process (GO:0160160)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of nicotine catabolic process.
positive regulation of 1,2-propanediol catabolic process (GO:0160161)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of 1,2-propanediol catabolic process.
Synonyms: positive regulation of propanediol catabolic process
CD27 signaling pathway (GO:0160162)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the cell surface receptor CD27 to its physiological ligand CD70, and ending with the regulation of a downstream cellular process, e.g. transcription.
S-nitrosoglutathione reductase (NADPH) activity (GO:0160163)
Namespace: molecular_function
Definition: Catalysis of the reaction: H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione.
negative regulation of chromatin looping (GO:0160164)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of chromatin looping.
CD8-positive, alpha-beta T cell homeostasis (GO:0160165)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of CD8-positive alpha-beta T cells such that the total number of CD8-positive alpha-beta T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Synonyms: CD8+ T cell homeostasis; CD8-positive T cell homeostasis
2-oxoadipate dehydrogenase activity (GO:0160166)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-oxoadipate + H+ + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase].
oxoadipate dehydrogenase complex (GO:0160167)
Namespace: cellular_component
Definition: A multi-enzyme complex that catalyzes the oxidative decarboxylation of 2-oxoadipate to glutaryl-CoA, thereby acting in the final step of lysine and tryptophan catabolism in mitochondria. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: 2-oxoadipate dehydrogenase (E1), dihydrolipoamide S-glutaryltransferase (E2) and dihydrolipoamide dehydrogenase (E3).
Synonyms: OADHC
Comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms '2-oxoadipate dehydrogenase activity ; GO:0160166' (E1), 'dihydrolipoyllysine-residue glutaryltransferase activity ; GO:0120571' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3).
T=9 icosahedral viral capsid (GO:0160168)
Namespace: cellular_component
Definition: The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=9 symmetry. The T=9 capsid is composed of 12 pentameric and 80 hexameric capsomeres.
T=21/pseudo21 icosahedral capsid (GO:0160169)
Namespace: cellular_component
Definition: The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=21 or pseudo T=21 symmetry.
T=27/pseudo27 icosahedral capsid (GO:0160170)
Namespace: cellular_component
Definition: The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=27 or pseudo T=27 symmetry.
T=28 icosahedral capsid (GO:0160171)
Namespace: cellular_component
Definition: The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=28 symmetry.
T=31/pseudo31 icosahedral capsid (GO:0160172)
Namespace: cellular_component
Definition: The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=31 or pseudo T=31 symmetry.
histamine transmembrane transporter activity (GO:0160173)
Namespace: molecular_function
Definition: Enables the transfer of histamine from one side of a membrane to the other.
cortical rotation (GO:0160174)
Namespace: biological_process
Definition: A cellular developmental process by which the outer layer of the cell (the cortex) rotates relative to the inner cytoplasm.
somatic muscle attachment to chitin-based cuticle (GO:0160175)
Namespace: biological_process
Definition: The developmental process in which a somatic muscle attaches to the chitin-based cuticle. In insects, this may occur via a specialized epithelial cell adherence to the chitinous extracellular matrix and to muscle cells through their basement membrane.
magnesium ion transport from cytosol to endoplasmic reticulum (GO:0160176)
Namespace: biological_process
Definition: The directed movement of magnesium ion from cytosol to endoplasmic reticulum.
positive regulation of autophagosome-lysosome fusion (GO:0160177)
Namespace: biological_process
Definition: Any process that activates or increases the rate which autophagosomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects).
dipeptide uniporter activity (GO:0160178)
Namespace: molecular_function
Definition: Catalysis of the transport of a dipeptide across a membrane; transport is independent of the movement of any other molecular species.
intestinal iron absorption (GO:0160179)
Namespace: biological_process
Definition: A process in which iron is taken up from the contents of the intestine.
piperine biosynthetic process (GO:0160181)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of piperine.
nitrate reductase (quinone) activity (GO:0160182)
Namespace: molecular_function
Definition: Catalysis of the reaction: a quinol + nitrate = a quinone + H2O + nitrite.
Synonyms: dissimilatory nitrate reductase; dissimilatory nitrate reductase activity; nitrate reductase A activity; nitrate reductase Z activity; quinol-nitrate oxidoreductase activity
autophagosome-membrane adaptor activity (GO:0160183)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a target membrane and an autophagosome during autophagy.
paracellular transport (GO:0160184)
Namespace: biological_process
Definition: The directed movement of substance through the space in between adjacent cells, rather than through the cells themselves.
phospholipase C activator activity (GO:0160185)
Namespace: molecular_function
Definition: Binds to and increases the activity of the enzyme phospholipase C.
phospholipase C inhibitor activity (GO:0160186)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of the enzyme phospholipase C.
paracellular tight junction channel activity (GO:0160187)
Namespace: molecular_function
Definition: Enables size- and charge-selective transport of solutes through a tight junction barrier paracellularly, across the epithelium.
Synonyms: claudin pore
obsolete sterol:proton antiporter activity (GO:0160188)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a sterol from one side of a membrane to the other according to the reaction: H+(out) + sterol(in) = H+(in) + sterol(out).
Comment: The reason for obsoletion is that this term was added in error.
peroxisomal-mitochondrial contact site (GO:0160189)
Namespace: cellular_component
Definition: An organelle membrane contact site between peroxisomal membrane and mitochondrial outer membrane.
Synonyms: PerMit contact; PerMit contact site
peroxisome-mitochondrion membrane tether activity (GO:0160190)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together the peroxisome and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.
steroid 22S-hydroxylase activity (GO:0160191)
Namespace: molecular_function
Definition: Catalysis of the reaction: a C28-steroid + O2 + reduced NADPH--hemoprotein reductase = a (22S)-22-hydroxy C28-steroid + H+ + H2O + oxidized NADPH--hemoprotein reductase. Also catalyzes the C-22 hydroxylation of a variety of C27 and C29 steroids.
Synonyms: steroid C-22 hydroxylase activity
autophagosome-dependent secretion (GO:0160192)
Namespace: biological_process
Definition: A process of exocytosis that uses the autophagy machinery to facilitate secretion of the cytosolic cargo such as leaderless cytosolic proteins which cannot enter the conventional secretory pathway operating via the endoplasmic reticulum and the Golgi apparatus.
Synonyms: autophagy-dependent secretion; secretory autophagy
L-lactate dehydrogenase inhibitor activity (GO:0160193)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of L-lactate dehydrogenase.
stereocilium bundle organization (GO:0160194)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a sensory hair cell stereocilium bundle.
negative regulation of phospholipase C/protein kinase C signal transduction (GO:0160195)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C/protein kinase C signal transduction.
Synonyms: negative regulation of PLC/PKC signal transduction
polyprenol dehydrogenase (NAD+) activity (GO:0160196)
Namespace: molecular_function
Definition: Catalysis of the reaction: a di-trans,poly-cis-polyprenol + NAD+ = a di-trans,poly-cis-polyprenal + NADH + H+.
Synonyms: polyprenol dehydrogenase activity
dolichal reductase (NADPH) activity (GO:0160197)
Namespace: molecular_function
Definition: Catalysis of the reaction: a di-trans,poly-cis-dolichol + NADP+ = a di-trans,poly-cis-dolichal + NADPH + H+.
Synonyms: dolichal reductase [NAD(P)+] activity; dolichal reductase [NAD(P)H] activity
polyprenal reductase activity (GO:0160198)
Namespace: molecular_function
Definition: Catalysis of the reaction: ditrans,polycis-polyprenal+ H+ + NADPH = ditrans,polycis-dolichal+ NADP.
positive regulation of 7-methylguanosine mRNA capping (GO:0160199)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of 7-methylguanosine mRNA capping.
polaroplast (GO:0160201)
Namespace: cellular_component
Definition: A membrane-bounded organelle found in a microsporidian spore,  that swells with water, and exerts pressure to rupture the polar cap and evert the polar tube through which the sporoplasm escapes to infect the host.
polar tube anchoring disc (GO:0160202)
Namespace: cellular_component
Definition: A structural component of the microsporidian spore's invasion apparatus that is located at the anterior end of the spore and serves to attach the polar tube to the inside of the spore wall.
mitochondrial disulfide relay system (GO:0160203)
Namespace: biological_process
Definition: A protein folding process that facilitates the import of a subset of soluble proteins into mitochondrial intermembrane space via disulfide bond formation.
Synonyms: MIA pathway; mitochondrial intermembrane space assembly pathway
mitochondrion-mitochondrion outer membrane tether activity (GO:0160204)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together two mitochondrion membranes via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.
Synonyms: mitochondrion membrane tether activity; mitochondrion outer membrane tether activity
cysteine-dependent adenosine diphosphate thiazole synthase activity (GO:0160205)
Namespace: molecular_function
Definition: Catalysis of the reaction: [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide.
Synonyms: ADP-thiazole synthase activity; suicide thiamine thiazole synthase activity
tRNA (cytidine(32)/uridine(32)-2'-O-ribose)-methyltransferase activity (GO:0160206)
Namespace: molecular_function
Definition: Catalysis of the reaction: cytidine(32)/uridine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methyluridine(32) in tRNA + H+ + S-adenosyl-L-homocysteine.
Synonyms: TrMet(Xm32) activity; tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase activity
positive regulation of androgen receptor signaling pathway (GO:0160207)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of androgen receptor signaling.
FMRP-CYFIP1 complex (GO:0160209)
Namespace: cellular_component
Definition: A protein-containing complex that contains the fragile X mental retardation protein (FMRP) and cytoplasmic FMRP Interacting protein 1 (CYIFIP1), and is capable of inhibiting translation initiation by binding to the eIF4F complex.
L-serine O-succinyltransferase activity (GO:0160210)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-serine + succinyl-CoA = CoA + O-succinyl-L-serine.
apicoplast membrane (GO:0160211)
Namespace: cellular_component
Definition: Any of the lipid bilayers that surround an apicoplast and form the apicoplast envelope.
glycine-gated cation channel activity (GO:0160212)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a cation by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
beta-arrestin-dependent dopamine receptor signaling pathway (GO:0160213)
Namespace: biological_process
Definition: A beta-arrestin-dependent signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
endoplasmic reticulum-plasma membrane adaptor activity (GO:0160214)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a plasma membrane with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication.
protein lysine delactylase activity (GO:0160216)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] = (S)-lactate + L-lysyl-[protein].
negative regulation of transcription initiation-coupled chromatin remodeling (GO:0160217)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of transcription initiation-coupled chromatin remodeling.