LiteFold/GO huggingface dataset:
N-acylsphingosine amidohydrolase activity (GO:0017040)
Namespace: molecular_function
Definition: Catalysis of the reaction: an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine.
Synonyms: acylsphingosine deacylase activity; ceramidase activity; glycosphingolipid ceramide deacylase
obsolete galactosylgalactosylglucosylceramidase activity (GO:0017041)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose.
Synonyms: ceramide trihexosidase activity; ceramidetrihexosidase activity; ceramidetrihexoside alpha-galactosidase activity; D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity; trihexosyl ceramide galactosidase activity; trihexosylceramide alpha-galactosidase activity
Comment: This term was obsoleted because its corresponding EC has been remapped to 'alpha-galactosidase activity'; GO:0004557.
glycosylceramidase activity (GO:0017042)
Namespace: molecular_function
Definition: Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine.
Synonyms: cerebrosidase activity; glycosyl ceramide glycosylhydrolase activity; glycosyl-N-acylsphingosine glycohydrolase activity
obsolete adrenocorticotropin (GO:0017043)
Namespace: molecular_function
Definition: OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones.
Synonyms: adrenocorticotropin; corticotropin
Comment: This term was made obsolete because it represents a gene product.
melanocyte-stimulating hormone activity (GO:0017044)
Namespace: molecular_function
Definition: The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates.
Synonyms: alpha-melanocyte stimulating hormone activity; alpha-melanophore stimulating hormone activity; melanocyte stimulating hormone activity
corticotropin-releasing hormone activity (GO:0017045)
Namespace: molecular_function
Definition: The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.
Synonyms: adrenocorticotropin-releasing hormone
peptide hormone binding (GO:0017046)
Namespace: molecular_function
Definition: Binding to a peptide with hormonal activity in animals.
Synonyms: polypeptide hormone binding
obsolete D-erythro-sphingosine kinase activity (GO:0017050)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.
Synonyms: sphingosine kinase activity
Comment: This term was obsoleted because it represents a specific substrate of sphingosine kinase activity ; GO:0008481.
retinol dehydratase activity (GO:0017051)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol.
obsolete insulin-like growth factor binding protein (GO:0017052)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: insulin-like growth factor binding protein
Comment: This term was made obsolete because it represents a single gene product and not a complex.
transcription repressor complex (GO:0017053)
Namespace: cellular_component
Definition: A protein complex that possesses activity that prevents or downregulates transcription.
Synonyms: cytoplasmic transcriptional repressor complex; nuclear transcriptional repressor complex; transcription factor inhibitor complex; transcriptional repressor complex
negative cofactor 2 complex (GO:0017054)
Namespace: cellular_component
Definition: A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
negative regulation of RNA polymerase II transcription preinitiation complex assembly (GO:0017055)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
Synonyms: down regulation of RNA polymerase II transcriptional preinitiation complex assembly; down-regulation of RNA polymerase II transcriptional preinitiation complex assembly; downregulation of RNA polymerase II transcriptional preinitiation complex assembly; inhibition of RNA polymerase II transcriptional preinitiation complex assembly; negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly; negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; negative regulation of RNA polymerase II transcriptional preinitiation complex formation
structural constituent of nuclear pore (GO:0017056)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
Synonyms: nuclear pore activity; nucleocytoplasmic transporter activity
Comment: Note that this term is meant to be used for nuclear pore proteins. For importins and exportins, consider 'nuclear import signal receptor activity' or 'nuclear export signal receptor activity', respectively.
6-phosphogluconolactonase activity (GO:0017057)
Namespace: molecular_function
Definition: Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+.
Synonyms: 6-PGL; 6-phospho-D-glucono-1,5-lactone lactonohydrolase activity; phosphogluconolactonase activity
FH1 domain binding (GO:0017058)
Namespace: molecular_function
Definition: Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain.
serine palmitoyltransferase complex (GO:0017059)
Namespace: cellular_component
Definition: A protein complex that catalyses the condensation of L-serine with palmitoyl-CoA to form 3-ketosphinganine, the sphingoid base which is the starting point for all sphingolipids. In bacteria the enzyme is a cytoplasmic homodimer, whereas in eukaryotes the enzyme is a multiprotein complex localised to the endoplasmic reticulum. The eukaryotic complex consists of catalytic components (SPTLC1, SPTLC2 and SPTLC3 in humans; LCB1 and LCB2 in S. cerevisiae) and regulatory components, which include activators (SPTSSA/SPTSSB in humans, TSC3 in S. cerevisiae) and negative regulators (ORMDL1/ORMDL2/ORMDL3 in humans, ORM1/2 in S. cerevisiae ).
Synonyms: serine C-palmitoyltransferase complex; serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex; SPOTS complex; SPT
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity (GO:0017060)
Namespace: molecular_function
Definition: Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R.
Synonyms: (Le(a))-dependent (alpha-3/4)-fucosyltransferase activity; (Lea)-dependent (alpha-3/4)-fucosyltransferase activity; 3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; alpha(1,4)-L-fucosyltransferase activity; alpha-(1,3/1,4) fucosyltransferase III activity; alpha-(1,4)-L-fucosyltransferase activity; alpha-(1->4)-L-fucosyltransferase activity; alpha-4-L-fucosyltransferase activity; beta-acetylglucosaminylsaccharide fucosyltransferase activity; blood group Lewis alpha-4-fucosyltransferase activity; blood-group substance Le(a)-dependent fucosyltransferase activity; blood-group substance Lea-dependent fucosyltransferase; fuca(1,3)-glycosidic linkage formation; FucT-II activity; galactoside 3(4)-L-fucosyltransferase activity; GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity; GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity; guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity; guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity; guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity; Lewis alpha-(1,3/4)-fucosyltransferase activity; Lewis alpha-(1->3/4)-fucosyltransferase activity; Lewis blood group alpha-(1,3/4)-fucosyltransferase activity; Lewis blood group alpha-(1->3/4)-fucosyltransferase activity; Lewis FT activity; Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity; Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity
S-methyl-5-thioadenosine phosphorylase activity (GO:0017061)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.
Synonyms: 5'-deoxy-5'-methylthioadenosine phosphorylase activity; 5'-methylthioadenosine phosphorylase activity; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity; MeSAdo phosphorylase activity; MeSAdo/Ado phosphorylase activity; methylthioadenosine nucleoside phosphorylase activity; methylthioadenosine phosphorylase activity; MTA phosphorylase activity; MTAPase activity; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity
respiratory chain complex III assembly (GO:0017062)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents.
Synonyms: coenzyme Q and cytochrome c reductase complex assembly; coenzyme Q and cytochrome c reductase complex biogenesis; complex III assembly; complex III biogenesis; cytochrome bc(1) complex assembly; cytochrome bc(1) complex biogenesis
obsolete phosphatidylserine-specific phospholipase A1 activity (GO:0017063)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion.
Synonyms: phosphatidylserine-specific phospholipase A1 activity
Comment: This term was made obsolete because the definition does not match the term name.
single-strand selective uracil DNA N-glycosylase activity (GO:0017065)
Namespace: molecular_function
Definition: Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA.
Synonyms: single-strand selective monofunctional uracil-DNA glycosylase activity
tyrosine-ester sulfotransferase activity (GO:0017067)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H+.
Synonyms: 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity; aryl sulfotransferase IV; L-tyrosine methyl ester sulfotransferase activity; tyrosine-ester sulphotransferase activity
snRNA binding (GO:0017069)
Namespace: molecular_function
Definition: Binding to a small nuclear RNA (snRNA).
Synonyms: base pairing with snRNA; small nuclear RNA binding
U6 snRNA binding (GO:0017070)
Namespace: molecular_function
Definition: Binding to a U6 small nuclear RNA (U6 snRNA).
intracellular cyclic nucleotide activated cation channel complex (GO:0017071)
Namespace: cellular_component
Definition: A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts.
obsolete tubulin-specific chaperone activity (GO:0017072)
Namespace: molecular_function
Definition: OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function.
Synonyms: tubulin-specific chaperone activity
Comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
obsolete procollagen N-endopeptidase activity (GO:0017074)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln.
Synonyms: aminoprocollagen peptidase activity; aminoterminal procollagen peptidase activity; procollagen aminopeptidase activity; procollagen aminoterminal protease activity; procollagen N-endopeptidase activity; procollagen N-proteinase activity; procollagen N-terminal peptidase activity; procollagen N-terminal proteinase activity; type I/II procollagen N-proteinase activity; type III procollagen
Comment: This term was made obsolete because it represents a gene product.
syntaxin-1 binding (GO:0017075)
Namespace: molecular_function
Definition: Binding to a syntaxin-1 SNAP receptor.
purine nucleotide binding (GO:0017076)
Namespace: molecular_function
Definition: Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate.
oxidative phosphorylation uncoupler activity (GO:0017077)
Namespace: molecular_function
Definition: Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms: mitochondrial uncoupling protein activity; uncoupling protein activity
obsolete Hsc70 protein regulator activity (GO:0017078)
Namespace: molecular_function
Definition: OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70.
Synonyms: Hsc70 interacting protein; Hsc70 protein regulator activity
Comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'.
sodium channel regulator activity (GO:0017080)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a sodium channel.
chloride channel regulator activity (GO:0017081)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a chloride channel.
obsolete mineralocorticoid receptor activity (GO:0017082)
Namespace: molecular_function
Definition: OBSOLETE. Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by binding to a specific DNA sequence in order to modulate transcription by RNA polymerase II.
Synonyms: aldosterone receptor
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity (GO:0017083)
Namespace: molecular_function
Definition: Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R.
Synonyms: galactoside 3-fucosyltransferase activity; galactoside 3-L-fucosyltransferase activity; GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity; GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity; GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity; guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity; guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity; Lewis-negative alpha-3-fucosyltransferase activity; plasma alpha-3-fucosyltransferase activity
delta1-pyrroline-5-carboxylate synthetase activity (GO:0017084)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H+ + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP+ + phosphate.
Synonyms: D1-pyrroline-5-carboxylate synthetase activity
response to insecticide (GO:0017085)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
Synonyms: insecticide resistance; insecticide susceptibility/resistance
obsolete 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex (GO:0017086)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate.
Synonyms: BCADH; branched-chain alpha-ketoacid dehydrogenase complex
Comment: The reason for obsoletion is that this term is equivalent to GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex.
mitochondrial processing peptidase complex (GO:0017087)
Namespace: cellular_component
Definition: A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion.
Comment: Note that monomeric mitochondrial processing peptidases have been observed.
obsolete X-Pro dipeptidyl-peptidase activity (GO:0017088)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile.
Synonyms: X-Pro dipeptidyl-peptidase activity; Xaa-Pro dipeptidyl-peptidase activity
Comment: This term was made obsolete because it represents a gene product.
glycolipid transfer activity (GO:0017089)
Namespace: molecular_function
Definition: Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.
Synonyms: glycolipid carrier activity; glycolipid transporter activity; intermembrane glycolipid transfer activity; intermembrane glycolipid transporter activity
meprin A complex (GO:0017090)
Namespace: cellular_component
Definition: A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues.
Synonyms: PABA peptide hydrolase complex
obsolete sterol regulatory element-binding protein site 2 protease activity (GO:0017092)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus.
Synonyms: SREBP site 2 protease activity; sterol regulatory element-binding protein site 2 protease activity
Comment: This term was made obsolete because it represents a gene product.
obsolete sterol regulatory element-binding protein protease activity (GO:0017093)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.
Synonyms: SREBP protease activity; sterol regulatory element-binding protein protease activity
Comment: This term was made obsolete because it represents a gene product.
obsolete sterol regulatory element-binding protein site 1 protease activity (GO:0017094)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves.
Synonyms: SREBP site 1 protease activity; sterol regulatory element-binding protein site 1 protease activity
Comment: This term was made obsolete because it represents a gene product.
heparan sulfate 6-sulfotransferase activity (GO:0017095)
Namespace: molecular_function
Definition: Catalysis of the reaction: alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H+.
Synonyms: heparan sulfate 6-O-sulfotransferase activity; heparan sulphate 6-O-sulphotransferase activity; heparin 6-O-sulfotransferase activity
acetylserotonin O-methyltransferase activity (GO:0017096)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine.
Synonyms: acetylserotonin methyltransferase activity; hydroxyindole methyltransferase activity; hydroxyindole O-methyltransferase activity; N-acetylserotonin O-methyltransferase activity; S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity
sulfonylurea receptor binding (GO:0017098)
Namespace: molecular_function
Definition: Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.
Synonyms: sulfonylurea receptor ligand; sulphonylurea receptor binding
aminoacyl-tRNA synthetase multienzyme complex (GO:0017101)
Namespace: cellular_component
Definition: A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
Synonyms: aminoacyl-tRNA synthetase complex; multisynthetase complex
methionyl glutamyl tRNA synthetase complex (GO:0017102)
Namespace: cellular_component
Definition: A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers.