LiteFold/GO huggingface dataset:
lipoprotein releasing activity (GO:0140306)
Namespace: molecular_function
Definition: The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex.
phospholipase C-activating N-formyl peptide-activated signaling pathway (GO:0140307)
Namespace: biological_process
Definition: A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by an N-formyl peptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. chemotaxis. N-formyl peptides include N-formylmethionyl-leucyl-phenylalanine (fMLF, fMLP or N-formyl-met-leu-phe), an N-formylated tripeptide sometimes simply referred to as chemotactic peptide. fMLF is a potent polymorphonuclear leukocyte (PMN) chemotactic factor and is also a macrophage activator.
Synonyms: fMLP-activated G protein-coupled receptor signaling pathway
insulin-like growth factor binding receptor complex (GO:0140308)
Namespace: cellular_component
Definition: A plasma membrane-localized protein complex that binds insulin-like growth factors (IGF1 or IGF2). This class includes both signaling receptor complexes, such as the insulin-like growth factor 1 receptor (IGF1R) complex, which possesses intrinsic tyrosine kinase activity and initiates intracellular signaling cascades upon ligand binding, and non-signaling receptor complexes such as the insulin-like growth factor 2 receptor (IGF2R), which functions to sequester IGF2 and regulate its bioavailability by directing it to lysosomal degradation. These complexes regulate cell growth, proliferation, survival, and development by modulating IGF signaling.
Synonyms: IGF-binding receptor complex
unfolded protein holdase activity (GO:0140309)
Namespace: molecular_function
Definition: A protein carrier activity that binds to a protein in an unfolded state and escorts it to an acceptor molecule or to a specific location. The unfolded protein carrier prevents aggregation of the target protein while it's being delivers to its final destination.
Synonyms: holdase; holdase-carrier chaperone; unfolded protein carrier activity
Comment: Note that an holdase binds an unfolded protein and keeps it unfolded, unlike a protein folding chaperone, which binds an unfolded protein to fold it.
positive regulation of peptidoglycan biosynthetic process (GO:0140310)
Namespace: biological_process
Definition: Any process that increases the rate, frequency, or extent of peptidoglycan biosynthetic process.
protein sequestering activity (GO:0140311)
Namespace: molecular_function
Definition: Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
cargo adaptor activity (GO:0140312)
Namespace: molecular_function
Definition: Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.
Synonyms: endocytic adaptor activity
molecular sequestering activity (GO:0140313)
Namespace: molecular_function
Definition: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
calcium ion sequestering activity (GO:0140314)
Namespace: molecular_function
Definition: Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
iron ion sequestering activity (GO:0140315)
Namespace: molecular_function
Definition: Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
obsolete vesicular transport adaptor activity (GO:0140316)
Namespace: molecular_function
Definition: OBSOLETE. Binding directly to sorting signals in the cytosolic tails of transmembrane cargos (or transmembrane cargo receptors serving as recognition interfaces for lumenal cargos), to concentrate them into vesicles or tubules for transport via intracellular vesicular transport or the secretory pathway.
Comment: Thi sterm was obsoleted because it represented an unnecessary grouping class.
export across cell outer membrane (GO:0140317)
Namespace: biological_process
Definition: The directed movement of a substance across the outer membrane in cells with two membranes.
protein transporter activity (GO:0140318)
Namespace: molecular_function
Definition: Directly binding to a specific protein and delivering it to a specific cellular location.
Synonyms: protein carrier activity; protein transport chaperone
Comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.
receptor decoy activity (GO:0140319)
Namespace: molecular_function
Definition: Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor.
Synonyms: decoy death receptor activity; decoy receptor
PAMP receptor decoy activity (GO:0140320)
Namespace: molecular_function
Definition: Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response.
Synonyms: pathogen-associated molecular pattern receptor decoy activity; pattern recognition receptor decoy activity
symbiont-mediated suppression of host autophagy (GO:0140321)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: negative regulation by symbiont of host autophagy; suppression of host autophagy
A1-type glycerophospholipase activity (GO:0140322)
Namespace: molecular_function
Definition: A glycerophospholipase activity that cleaves the fatty acid attached to the sn-1 position of the glycerol group of a glycerophospholipid.
obsolete solute:monoatomic anion antiporter activity (GO:0140323)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(in) + solute(out) = anion(out) + solute(in).
Synonyms: solute:anion antiporter activity
Comment: This term was obsoleted because it is an unnecessary grouping class.
lysophospholipase C activity (GO:0140324)
Namespace: molecular_function
Definition: Hydrolysis of a lysoglycerophospholipid at the first phosphodiester bond between the phosphate and glycerol.
negative regulation of protein localization to medial cortex (GO:0140325)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex.
ATPase-coupled intramembrane lipid carrier activity (GO:0140326)
Namespace: molecular_function
Definition: Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.
Synonyms: aminophospholipid-transporting ATPase; ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled phospholipid transporter activity; ATPase-dependent phospholipid transporter activity; phospholipid flippase activity; phospholipid translocating ATPase activity; phospholipid-translocating ATPase activity; phospholipid-transporting ATPase activity
flippase activity (GO:0140327)
Namespace: molecular_function
Definition: Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: flippase activity (exoplasmic to cytosolic leaflet)
Comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaflet of a membrane).
floppase activity (GO:0140328)
Namespace: molecular_function
Definition: Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: floppase activity (cytosolic to exoplasmic leaflet)
Comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the cytosolic to the exoplasmic leaflet of a membrane).
xenobiotic detoxification by transmembrane export across the cell outer membrane (GO:0140330)
Namespace: biological_process
Definition: A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane.
aminophospholipid translocation (GO:0140331)
Namespace: biological_process
Definition: The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
lipopolysaccharide transfer activity (GO:0140332)
Namespace: molecular_function
Definition: Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.
Synonyms: intermembrane lipopolysaccharide transfer activity; intermembrane lipopolysaccharide transporter activity; intermembrane LPS transporter activity; lipopolysaccharide carrier activity
glycerophospholipid flippase activity (GO:0140333)
Namespace: molecular_function
Definition: Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: glycerophospholipid flippase activity (exoplasmic to cytosolic leaflet)
GPI anchor phospholipase C activity (GO:0140335)
Namespace: molecular_function
Definition: Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol, by cleavage of the  first phosphodiester bond between the phosphate and glycerol.
Synonyms: glycoprotein phospholipase C activity; glycosylphosphatidyl inositol-anchor protein phospholipase C activity; GPI-PLC activity
glycosylphosphatidylinositol phospholipase D activity (GO:0140336)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
Synonyms: GPI phospholipase D activity; phosphatidylinositol phospholipase D activity
sphingomyelin transfer activity (GO:0140338)
Namespace: molecular_function
Definition: Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.
Synonyms: sphingomyelin carrier activity; sphingosine transmembrane transporter activity
phosphatidylglycerol transfer activity (GO:0140339)
Namespace: molecular_function
Definition: Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location.
Synonyms: phosphatidylglycerol carrier activity
cerebroside transfer activity (GO:0140340)
Namespace: molecular_function
Definition: Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location.
Synonyms: cerebroside carrier activity
phosphatidylethanolamine floppase activity (GO:0140341)
Namespace: molecular_function
Definition: Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaflet)
venom-mediated perturbation of heart contraction (GO:0140342)
Namespace: biological_process
Definition: A process in which an organism alters or subverts the heart contractility in another organism via the action of a venom.
phosphatidylserine transfer activity (GO:0140343)
Namespace: molecular_function
Definition: Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.
Synonyms: intermembrane phosphatidylserine carrier activity
triglyceride transfer activity (GO:0140344)
Namespace: molecular_function
Definition: Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location.
Synonyms: triglyceride carrier activity
phosphatidylserine flippase activity (GO:0140346)
Namespace: molecular_function
Definition: Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: phosphatidylserine flippase activity (exoplasmic to cytosolic leaflet)
N-retinylidene-phosphatidylethanolamine flippase activity (GO:0140347)
Namespace: molecular_function
Definition: Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet)
lysophosphatidylcholine flippase activity (GO:0140348)
Namespace: molecular_function
Definition: Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaflet)
laminin network (GO:0140349)
Namespace: cellular_component
Definition: A supramolecular network that forms mainly through linkages of the short laminin arms between the N-terminal regions of one alpha, one beta, and one gamma chain. The laminin network associates with the collagen network to create the stable, sheet-like structure of the basement membrane ECM.
Synonyms: laminin complex
inchworm-type cell migration (GO:0140350)
Namespace: biological_process
Definition: A type of amoeboid cell migration involving minimal contact between the cell and the surface, with the cell body standing upright and twisting, followed by rapid reattachment for directed movement.
glycosylceramide flippase activity (GO:0140351)
Namespace: molecular_function
Definition: Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar.
Synonyms: galactocerebroside flippase activity; galactosylceramide flippase activity; glucosylceramide flippase activity; glycoceramide flippase activity; glycosylceramide flippase activity (exoplasmic to cytosolic leaflet)
export from cell (GO:0140352)
Namespace: biological_process
Definition: The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.
Synonyms: efflux
lipid export from cell (GO:0140353)
Namespace: biological_process
Definition: The directed movement of a lipid from a cell, into the extracellular region.
Synonyms: lipid efflux
lipid import into cell (GO:0140354)
Namespace: biological_process
Definition: The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
Synonyms: lipid uptake
cargo receptor ligand activity (GO:0140355)
Namespace: molecular_function
Definition: The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.
Synonyms: cargo
L-lyxonate dehydratase activity (GO:0140356)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lyxonate =2-dehydro-3-deoxy-L-arabinonate + H2O.
heme export from vacuole to cytoplasm (GO:0140357)
Namespace: biological_process
Definition: The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol.
P-type transmembrane transporter activity (GO:0140358)
Namespace: molecular_function
Definition: Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
Synonyms: E1-E2 ATPase; P-type ATPase
ABC-type transporter activity (GO:0140359)
Namespace: molecular_function
Definition: Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
Synonyms: ABC transporter; ABC-type efflux permease activity; ABC-type efflux porter activity; ABC-type transmembrane transporter activity; ABC-type uptake permease activity; ATP binding cassette transporter; ATP-binding cassette (ABC) transporter activity; ATP-binding cassette transporter
cyclic-GMP-AMP transmembrane transporter activity (GO:0140360)
Namespace: molecular_function
Definition: Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other.
cyclic-GMP-AMP transmembrane import across plasma membrane (GO:0140361)
Namespace: biological_process
Definition: The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol.
TIS granule (GO:0140363)
Namespace: cellular_component
Definition: A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER).
GW body (GO:0140364)
Namespace: cellular_component
Definition: A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs.
Synonyms: GW-body
galectin lattice (GO:0140366)
Namespace: cellular_component
Definition: A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids.
antibacterial innate immune response (GO:0140367)
Namespace: biological_process
Definition: An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
decoy receptor complex (GO:0140368)
Namespace: cellular_component
Definition: A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound.
Synonyms: osteoclastogenesis inhibitory factor; osteoprotegerin complex
dbTF DNA binding stabilizer activity (GO:0140369)
Namespace: molecular_function
Definition: A protein binding activity that stimulates and stabilizes the binding of a DNA binding transcription factor to its genomic DNA target, without directly interacting with DNA itself.
Synonyms: DNA binding transcription factorDNA binding stabilizer activity
Comment: Note that this is different from a co-regulator activity (GO:0003712) which acts after DNA binding.
type II oncostatin-M receptor complex (GO:0140370)
Namespace: cellular_component
Definition: A heterodimeric receptor for the cytokine LIF (leukemia inhibitory factor). In humans the receptor complex is made up of the gene products gp130 and LIFR.
Synonyms: leukemia inhibitory factor receptor complex; oncostatin-M receptor complex
ornithine lipid biosynthetic process (GO:0140371)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of ornithine lipids, any of a class of phosphorus-free bacterial membrane lipids with an L-ornithine-derived head group.
obsolete histone H3-K14 ubiquitination (GO:0140373)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone.
Synonyms: histone H3 ubiquitination at K14; histone H3-K14 ubiquitylation; histone H3K14 ubiquitination
Comment: This term was obsoleted because it represents a molecular function.
antiviral innate immune response (GO:0140374)
Namespace: biological_process
Definition: A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
immune receptor activity (GO:0140375)
Namespace: molecular_function
Definition: Receiving a signal and transmitting it in a cell to initiate an immune response.
innate immune receptor activity (GO:0140376)
Namespace: molecular_function
Definition: Receiving a signal and transmitting it in a cell to initiate an innate immune response.
sophorolipid biosynthetic process (GO:0140377)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of sophorolipid, a class of glycolipids containing a 2-O-beta-D-glucopyranosyl-D-glucopyranose (sophorose) unit covalently linked to the hydroxyl of a omega-hydroxy long chain fatty acids or (omega-1)-hydroxy long chain fatty acids.
protein complex scaffold activity (GO:0140378)
Namespace: molecular_function
Definition: A structural molecule activity of a protein-containing complex component that serves to hold the complex together. Protein complex scaffolds are integral members of complexes.
Synonyms: protein-complex scaffolding activity; protein-containing complex scaffold activity
psilocybin biosynthetic process (GO:0140380)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product.
4-hydroxytryptamine 4-phosphate methyltransferase activity (GO:0140381)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) = 2 S-adenosyl-L-homocysteine + psilocybin.
Synonyms: norbaeocystin methyltransferase; psilocybin synthase
tryptamine 4-monooxygenase activity (GO:0140382)
Namespace: molecular_function
Definition: Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O.
4-hydroxytryptamine kinase activity (GO:0140383)
Namespace: molecular_function
Definition: Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+.