LiteFold/GO huggingface dataset:
MalFGK2 complex (GO:1990176)
Namespace: cellular_component
Definition: Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG.
Synonyms: MalF-MalG-MalK(2) complex; MalF-MalG-MalK-MalK complex; MalFGK(2) complex; maltose transport complex, core subunit; maltose transport MalFGK2 complex
Comment: The MalFGK2 complex lacks the maltose-binding subunit present in GO:1990060.
IHF-DNA complex (GO:1990177)
Namespace: cellular_component
Definition: A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid.
Synonyms: IHF complex; IHFa-IHFb-DNA complex
HU-DNA complex (GO:1990178)
Namespace: cellular_component
Definition: A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure.
Synonyms: HU complex
protein localization to actomyosin contractile ring (GO:1990179)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained at, the actomyosin contractile ring.
Synonyms: protein localisation to actomyosin contractile ring
mitochondrial tRNA 3'-end processing (GO:1990180)
Namespace: biological_process
Definition: The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.
Synonyms: tRNA 3' processing in mitochondria; tRNA 3' processing in mitochondrion; tRNA 3'-end processing in mitochondria
obsolete acetyl-CoA biosynthetic process from pantothenate (GO:1990181)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA.
Synonyms: acetyl-CoA anabolism from pantothenate; acetyl-CoA formation from pantothenate; acetyl-CoA synthesis from pantothenate
Comment: The reason for obsoletion is that these represent GO-CAMs.
exosomal secretion (GO:1990182)
Namespace: biological_process
Definition: The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Synonyms: exosomal protein secretion; exosomal secretory pathway; extracellular vesicular exosome secretion; multi-vesicular body fusion with plasma membrane; secretion of exosome
lymphatic vascular process in circulatory system (GO:1990183)
Namespace: biological_process
Definition: A circulatory process that occurs at the level of the lymphatic vasculature.
amino acid transport complex (GO:1990184)
Namespace: cellular_component
Definition: A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane.
regulation of lymphatic vascular permeability (GO:1990185)
Namespace: biological_process
Definition: Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid.
regulation of lymphatic vessel size (GO:1990186)
Namespace: biological_process
Definition: Any process that modulates the size of lymphatic vessels.
Synonyms: regulation of collecting lymphatic vessel size
obsolete protein localization to mRNA (GO:1990187)
Namespace: biological_process
Definition: OBSOLETE. A process in which a protein is transported to, or maintained at mRNA.
Synonyms: protein localization to mRNA
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
euchromatin binding (GO:1990188)
Namespace: molecular_function
Definition: Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin.
protein N-terminal-serine acetyltransferase activity (GO:1990189)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein].
Synonyms: peptide-serine-alpha-N-acetyltransferase activity
protein-N-terminal-glutamate acetyltransferase activity (GO:1990190)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide.
Synonyms: peptide-glutamate-alpha-N-acetyltransferase activity; protein-N-terminal-glutamate-alpha-N-acetyltransferase activity
collecting lymphatic vessel constriction (GO:1990192)
Namespace: biological_process
Definition: A decrease in the diameter of collecting lymphatic vessels.
Synonyms: lymphatic vessel myogenic constriction
BtuCD complex (GO:1990193)
Namespace: cellular_component
Definition: Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer.
Synonyms: BtuC-BtuD complex; cobalamin transport complex, core subunit; vitamin B12 transport complex, core subunit
cytoplasmic U snRNP body assembly (GO:1990194)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body.
Synonyms: U body assembly
macrolide transmembrane transporter complex (GO:1990195)
Namespace: cellular_component
Definition: A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes.
Synonyms: AcrAB-TolC complex; MacAB-TolC complex; macrolide transporter; macrolide transporter complex
MacAB-TolC complex (GO:1990196)
Namespace: cellular_component
Definition: The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC.
Synonyms: macrolide transporter MacAB-TolC complex
methionine-importing ABC transporter complex (GO:1990197)
Namespace: cellular_component
Definition: An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner.
Synonyms: ATP-binding cassette (ABC) methionine importer complex; ATP-dependent methionine importer complex; ATP-dependent methionine importing complex; ATP-dependent methionine-importing complex; methionine transport complex; methionine transporter; methionine transporter complex; methionine transporter complex, ATP-dependent; MetNI complex; MetNI transport complex; MetNI transporter; MetNI transporter complex; MetNIQ complex; MetNIQ transport complex; MetNIQ transporter; MetNIQ transporter complex
ModE complex (GO:1990198)
Namespace: cellular_component
Definition: A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism.
Synonyms: ModE dimer
MsbA transporter complex (GO:1990199)
Namespace: cellular_component
Definition: An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD).
Synonyms: MsbA complex; MsbA dimer
SsuD-SsuE complex (GO:1990200)
Namespace: cellular_component
Definition: A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation.
Synonyms: two-component alkanesulfonate monooxygenase system
alkanesulfonate monooxygenase complex (GO:1990201)
Namespace: cellular_component
Definition: A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer.
Synonyms: SsuD complex
FMN reductase complex (GO:1990202)
Namespace: cellular_component
Definition: A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer.
Synonyms: flavin oxidoreductase complex, NAD(P)H-dependent; FMN oxidoreductase complex, NAD(P)H-dependent; FMN reductase complex, NAD(P)H-dependent; SsuE complex
taurine dioxygenase complex (GO:1990205)
Namespace: cellular_component
Definition: A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD.
Synonyms: 2-aminoethanesulfonate dioxygenase complex; alpha-ketoglutarate-dependent taurine dioxygenase complex; TauD complex
EmrE multidrug transporter complex (GO:1990207)
Namespace: cellular_component
Definition: A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer.
Synonyms: EmrE complex
obsolete positive regulation by symbiont of RNA levels in host (GO:1990208)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because it represents a readout.
obsolete negative regulation by symbiont of RNA levels in host (GO:1990209)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because it represents a readout.
obsolete positive regulation by symbiont of indole acetic acid levels in host (GO:1990210)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: positive regulation by symbiont of auxin levels in host; positive regulation by symbiont of IAA levels in host
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete negative regulation by symbiont of salicylic acid levels in host (GO:1990213)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete negative regulation by symbiont of host protein levels (GO:1990214)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
symbiont-mediated perturbation of host vesicle-mediated transport (GO:1990215)
Namespace: biological_process
Definition: A process in which a symbiont alters or subverts vesicle-mediated transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: negative regulation by symbiont of host intracellular transport; symbiont-mediated perturbation of host endosomal trafficking
symbiont-mediated suppression of host phytoalexin production (GO:1990217)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the production of phytoalexins in the host organism. Phytoalexins are produced by plants to fight against pathogens. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: negative regulation by symbiont of host phytoalexin production; suppression by symbiont of host phytoalexin production
obsolete positive regulation by symbiont of abscisic acid levels in host (GO:1990218)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete positive regulation by symbiont of host protein levels (GO:1990219)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
GroEL-GroES complex (GO:1990220)
Namespace: cellular_component
Definition: Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins.
Synonyms: bacterial chaperonin ATPase complex; bacterial chaperonin complex
L-cysteine desulfurase complex (GO:1990221)
Namespace: cellular_component
Definition: A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes.
Synonyms: IscS; NifS; SufS complex
ProVWX complex (GO:1990222)
Namespace: cellular_component
Definition: The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions.
Synonyms: ATP-binding cassette (ABC) transporter complex ProVWX
obsolete positive regulation by symbiont of cytokinin levels in host (GO:1990223)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete NMN phosphatase activity (GO:1990224)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate.
Synonyms: beta-nicotinamide D-ribonucleotide phosphatase activity; nicotinamide mononucleotide phosphatase activity
Comment: The reason for obsoletion is that it is more specific than the specificity of any known gene product.
rhoptry neck (GO:1990225)
Namespace: cellular_component
Definition: Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion.
histone methyltransferase binding (GO:1990226)
Namespace: molecular_function
Definition: Binding to a histone methyltransferase enzyme.
sulfurtransferase complex (GO:1990228)
Namespace: cellular_component
Definition: A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).
Synonyms: SufE complex; SufE dimer; sulfur transfer complex; ThiF-ThiS complex
iron-sulfur cluster assembly complex (GO:1990229)
Namespace: cellular_component
Definition: A protein complex capable of assembling an iron-sulfur (Fe-S) cluster.
Synonyms: Fe-S cluster assembly complex; SufBCD complex
iron-sulfur cluster transfer complex (GO:1990230)
Namespace: cellular_component
Definition: A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor), which may be a target protein or another Fe-S assembly complex. In humans, it consists of HSPA9, HSCB, GLRX5, ABCB7 and GFER.
Synonyms: Fe-S cluster transfer complex; IscA complex; SufA complex; SufA dimer
STING complex (GO:1990231)
Namespace: cellular_component
Definition: A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response.
Synonyms: stimulator of interferon genes complex
phosphomannomutase complex (GO:1990232)
Namespace: cellular_component
Definition: A protein complex capable of phosphomannomutase activity.
Synonyms: PMM-1 complex; PMM-1 dimer; PMM-2 complex; PMM-2 dimer
intramolecular phosphotransferase complex (GO:1990233)
Namespace: cellular_component
Definition: A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule.
transferase complex (GO:1990234)
Namespace: cellular_component
Definition: A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
diamine N-acetyltransferase complex (GO:1990235)
Namespace: cellular_component
Definition: A protein complex which is capable of diamine N-acetyltransferase activity.
Synonyms: SAT complex; SAT tetramer; spermidine acetyltransferase complex
double-stranded DNA endonuclease activity (GO:1990238)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks.
Synonyms: double-stranded DNA endodeoxyribonuclease activity; dsDNA-specific endodeoxyribonuclease activity
steroid hormone binding (GO:1990239)
Namespace: molecular_function
Definition: Binding to a steroid hormone.
obsolete nucleotide binding complex (GO:1990241)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex that interacts selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. An example of this is STING in E. coli (Q86WV6).
Synonyms: nucleotide binding complex
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete innate immune response complex (GO:1990242)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex involved in the innate immune response.
Synonyms: innate immune response complex
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
atf1-pcr1 complex (GO:1990243)
Namespace: cellular_component
Definition: A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE).
histone H2AT120 kinase activity (GO:1990244)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A.
Synonyms: histone H2A-T120 kinase activity; histone H2AS120 kinase activity; histone kinase activity (H2A-T120 specific); histone threonine kinase activity (H2A-T120 specific)
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes, but corresponds to T119 in Drosophila and S121 in yeast and Tetrahymena. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
obsolete histone H2A-T120 phosphorylation (GO:1990245)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone.
Synonyms: histone H2A phosphorylation at T120; histone H2AT120 phosphorylation
Comment: This term was obsoleted because it represents a molecular function.
uniplex complex (GO:1990246)
Namespace: cellular_component
Definition: A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
Synonyms: mitochondrial uniporter complex; mitochondrial uniporter holocomplex
N6-methyladenosine-containing RNA reader activity (GO:1990247)
Namespace: molecular_function
Definition: A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs.
Synonyms: N6-methyladenosine-containing RNA binding
nucleotide-excision repair, DNA damage recognition complex (GO:1990249)
Namespace: cellular_component
Definition: A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex.
nuclear exosome focus (GO:1990251)
Namespace: cellular_component
Definition: An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome.
Synonyms: Mmi1 nuclear focus; nuclear body