LiteFold/GO huggingface dataset:
pectinesterase inhibitor activity (GO:0046910)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of pectinesterase.
Comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'.
metal chelating activity (GO:0046911)
Namespace: molecular_function
Definition: The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring.
Synonyms: heavy metal chelation; metal chelation
acyltransferase activity, acyl groups converted into alkyl on transfer (GO:0046912)
Namespace: molecular_function
Definition: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.
Synonyms: acyltransferase, acyl groups converted into alkyl on transfer; transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
transition metal ion binding (GO:0046914)
Namespace: molecular_function
Definition: Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
transition metal ion transmembrane transporter activity (GO:0046915)
Namespace: molecular_function
Definition: Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
obsolete intracellular transition metal ion homeostasis (GO:0046916)
Namespace: biological_process
Definition: OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of transition metal ions within a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
Synonyms: cellular transition metal ion homeostasis
Comment: This term was obsoleted because it is an unnecessary grouping class.
triphosphoribosyl-dephospho-CoA synthase activity (GO:0046917)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine.
Synonyms: 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity; ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity; ATP:dephospho-CoA 5-triphosphoribosyl transferase activity; CitG activity
obsolete N-terminal peptidyl-glycine N-palmitoylation (GO:0046918)
Namespace: biological_process
Definition: OBSOLETE. The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine.
Comment: This term was obsoleted because it represents a molecular function.
alpha-(1->3)-fucosyltransferase activity (GO:0046920)
Namespace: molecular_function
Definition: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage.
Synonyms: alpha(1,3)-fucosyltransferase activity; alpha-(1,3)-fucosyltransferase activity; alpha-1,3-fucosyltransferase activity
alpha-(1->6)-fucosyltransferase activity (GO:0046921)
Namespace: molecular_function
Definition: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.
Synonyms: alpha(1,6)-fucosyltransferase activity; alpha-(1,6)-fucosyltransferase activity; alpha-1,6-fucosyltransferase activity
peptide-O-fucosyltransferase activity (GO:0046922)
Namespace: molecular_function
Definition: Catalysis of the transfer of an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
Synonyms: GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity; GDP-fucose protein O-fucosyltransferase activity; GDP-fucose:polypeptide fucosyltransferase activity; GDP-L-fucose:polypeptide fucosyltransferase activity
ER retention sequence binding (GO:0046923)
Namespace: molecular_function
Definition: Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.
Synonyms: endoplasmic reticulum retention sequence binding
obsolete peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine (GO:0046924)
Namespace: biological_process
Definition: OBSOLETE. The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine (GO:0046925)
Namespace: biological_process
Definition: OBSOLETE. The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine (GO:0046926)
Namespace: biological_process
Definition: OBSOLETE. The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine.
Comment: This term was obsoleted because it represents a molecular function.
obsolete peptidyl-threonine racemization (GO:0046927)
Namespace: biological_process
Definition: OBSOLETE. The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine.
Comment: This term was obsoleted because it represents a molecular function.
regulation of neurotransmitter secretion (GO:0046928)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
negative regulation of neurotransmitter secretion (GO:0046929)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.
Synonyms: conotoxin activity; down regulation of neurotransmitter secretion; down-regulation of neurotransmitter secretion; downregulation of neurotransmitter secretion; inhibition of neurotransmitter secretion
pore complex assembly (GO:0046931)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases.
Synonyms: pore biosynthesis; pore complex biogenesis; pore formation; pore-forming toxin activity
Comment: See also the cellular component term 'pore complex ; GO:0046930'.
sodium-transporting ATP synthase activity, rotational mechanism (GO:0046932)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other by a rotational mechanism according to the reaction: 4 Na+(out) + ADP + phosphate + H+ => 4 Na+(in) + ATP + H2O.
Synonyms: sodium-translocating F-type ATPase activity; sodium-transporting two-sector ATPase activity
proton-transporting ATP synthase activity, rotational mechanism (GO:0046933)
Namespace: molecular_function
Definition: Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in).
Synonyms: H+-transporting ATP synthase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + H+.
Synonyms: phosphatidylinositol 3-kinase activity, class I; phosphatidylinositol 3-kinase activity, class II; phosphatidylinositol 3-kinase, class I, catalyst activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; type I phosphoinositide 3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity (GO:0046935)
Namespace: molecular_function
Definition: Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.
Synonyms: 1-phosphatidylinositol 3-kinase regulator activity; phosphatidylinositol 3-kinase, class I, regulator activity
Comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'.
phytochelatin metabolic process (GO:0046937)
Namespace: biological_process
Definition: The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11.
Synonyms: cadystin metabolic process; cadystin metabolism; phytochelatin metabolism
phytochelatin biosynthetic process (GO:0046938)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11.
Synonyms: cadystin biosynthetic process; phytochelatin anabolism; phytochelatin biosynthesis; phytochelatin formation; phytochelatin synthesis
obsolete nucleotide phosphorylation (GO:0046939)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.
Comment: The reason for obsoletion is that this term represents a single step MF.
nucleoside monophosphate phosphorylation (GO:0046940)
Namespace: biological_process
Definition: The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.
azetidine-2-carboxylic acid acetyltransferase activity (GO:0046941)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid.
carboxylic acid transport (GO:0046942)
Namespace: biological_process
Definition: The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
carboxylic acid transmembrane transporter activity (GO:0046943)
Namespace: molecular_function
Definition: Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
protein carbamoylation (GO:0046944)
Namespace: biological_process
Definition: The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2.
Synonyms: protein amino acid carbamoylation
obsolete N-terminal peptidyl-alanine N-carbamoylation (GO:0046945)
Namespace: biological_process
Definition: OBSOLETE. The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine.
Synonyms: N-terminal peptidyl-alanine N-carbamylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete hydroxylysine metabolic process (GO:0046946)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases.
Synonyms: hydroxylysine metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete hydroxylysine biosynthetic process (GO:0046947)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid.
Synonyms: hydroxylysine anabolism; hydroxylysine biosynthesis; hydroxylysine formation; hydroxylysine synthesis
Comment: The reason for obsoletion is that hydroxylysine is formed through post-translational modification of lysine residues in proteins (particularly collagen) by procollagen-lysine 5-dioxygenase, not through a separate biosynthetic pathway. The term was incorrectly classified as an amino acid biosynthetic process.
obsolete hydroxylysine catabolic process (GO:0046948)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid.
Synonyms: hydroxylysine breakdown; hydroxylysine catabolism; hydroxylysine degradation
Comment: The reason for obsoletion is that there is no evidence that this process exists.
fatty-acyl-CoA biosynthetic process (GO:0046949)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.
Synonyms: fatty acyl CoA biosynthetic process; fatty-acyl-CoA anabolism; fatty-acyl-CoA biosynthesis; fatty-acyl-CoA formation; fatty-acyl-CoA synthesis
obsolete cellular ketone body metabolic process (GO:0046950)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
Synonyms: cellular ketone body metabolism
Comment: The reason for obsoletion is that this term is redundant to GO:1902224, ketone body metabolic process
ketone body biosynthetic process (GO:0046951)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
Synonyms: ketone body anabolism; ketone body biosynthesis; ketone body formation; ketone body synthesis
ketone body catabolic process (GO:0046952)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.
Synonyms: ketolysis; ketone body breakdown; ketone body catabolism; ketone body degradation; utilization of ketone bodies
positive phototaxis (GO:0046956)
Namespace: biological_process
Definition: The directed movement of a cell or organism towards a source of light.
Synonyms: positive phototactic behavior; positive phototactic behaviour; positive taxis in response to light
negative phototaxis (GO:0046957)
Namespace: biological_process
Definition: The directed movement of a cell or organism away from a source of light.
Synonyms: negative phototactic behavior; negative phototactic behaviour; negative taxis in response to light
nonassociative learning (GO:0046958)
Namespace: biological_process
Definition: A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.
Synonyms: unconditional response
habituation (GO:0046959)
Namespace: biological_process
Definition: A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
sensitization (GO:0046960)
Namespace: biological_process
Definition: An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched.
proton-transporting ATPase activity, rotational mechanism (GO:0046961)
Namespace: molecular_function
Definition: Enables the transfer of protons from one side of a membrane to the other by a rotational mechanism according to the reaction: ATP + H2O + 4 H+(in) => ADP + phosphate + 5 H+(out).
Synonyms: ATP phosphohydrolase (H+-transporting) activity; ATP synthase activity; chloroplast ATPase activity; F(0)F(1)-ATPase activity; F(1)-ATPase activity; F(o)F(1)-ATPase activity; F0F1-ATPase; F1-ATPase; FoF1-ATPase; H+-transporting ATP synthase activity; H+-transporting ATPase activity; hydrogen ion translocating A-type ATPase activity; hydrogen ion translocating F-type ATPase activity; hydrogen ion translocating V-type ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; hydrogen ion transporting two-sector ATPase activity; mitochondrial ATPase activity
sodium-transporting ATPase activity, rotational mechanism (GO:0046962)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other by a rotational mechanism according to the reaction: 4 Na+(in) + ATP + H2O => 4 Na+(out) + ADP + phosphate + H+.
Synonyms: ATP phosphohydrolase (Na+-transporting) activity; ATP synthase, sodium ion specific activity; Na(+)-translocating ATPase activity; Na(+)-transporting two-sector ATPase activity; Na+-translocating ATPase activity; Na+-translocating F1Fo-ATPase; Na+-transporting two-sector ATPase; sodium transporting ATPase activity, rotational mechanism; sodium-translocating F-type ATPase activity; sodium-translocating V-type ATPase activity; sodium-transporting two-sector ATPase activity; vacuolar-type Na+-ATPase; vacuolar-type Na+-translocating ATPase
Comment: Found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis; similar to EC:7.1.2.2 but pumps Na+ rather than H+. (Source: EC:7.2.2.1)
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity (GO:0046964)
Namespace: molecular_function
Definition: Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other.
Synonyms: 3'-phosphoadenosine 5'-phosphosulphate transporter activity; adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity; PAPS transporter activity
nuclear retinoid X receptor binding (GO:0046965)
Namespace: molecular_function
Definition: Binding to a nuclear retinoid X receptor.
Synonyms: retinoid X receptor binding; RXR binding
nuclear thyroid hormone receptor binding (GO:0046966)
Namespace: molecular_function
Definition: Binding to a nuclear thyroid hormone receptor.
Synonyms: ligand-dependent thyroid hormone receptor interactor activity; thyroid hormone receptor binding
cytosol to endoplasmic reticulum transport (GO:0046967)
Namespace: biological_process
Definition: The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell.
Synonyms: cytosol to ER transport
peptide antigen transport (GO:0046968)
Namespace: biological_process
Definition: The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
histone H3K9 deacetylase activity, NAD-dependent (GO:0046969)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + NAD+ + H2O = histone H3 L-lysine (position 9) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K9 to NAD, producing nicotinamide.
Synonyms: NAD-dependent H3-K9 histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone H3K9 deacetylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H4K16 deacetylase activity, NAD-dependent (GO:0046970)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + NAD+ + H2O = histone H4 L-lysine (position 16) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H4K16 to NAD, producing nicotinamide.
Synonyms: NAD-dependent histone deacetylase activity (H4-K16 specific); NAD-dependent histone H4-K16 deacetylase activity; NAD-dependent histone H4K16 deacetylase activity
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H4K16 acetyltransferase activity (GO:0046972)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.
Synonyms: histone acetylase activity (H4-K16 specific); histone acetyltransferase activity (H4-K16 specific); histone lysine acetyltransferase activity (H4-K16 specific)
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
obsolete histone lysine N-methyltransferase activity (H3-K24 specific) (GO:0046973)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein.
Synonyms: histone lysine N-methyltransferase activity (H3-K24 specific)
Comment: This term was made obsolete because there is no lysine at position 24 of histone H3.