LiteFold/GO huggingface dataset:
obsolete calcium ion binding involved in regulation of cytosolic calcium ion concentration (GO:0099510)
Namespace: molecular_function
Definition: OBSOLETE. The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations.
Synonyms: regulation of cytosolic calcium ion concentration by calcium ion buffering
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels (GO:0099511)
Namespace: molecular_function
Definition: Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
supramolecular fiber (GO:0099512)
Namespace: cellular_component
Definition: A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
Synonyms: fibril
polymeric cytoskeletal fiber (GO:0099513)
Namespace: cellular_component
Definition: A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.
synaptic vesicle cytoskeletal transport (GO:0099514)
Namespace: biological_process
Definition: The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors.
actin filament-based transport (GO:0099515)
Namespace: biological_process
Definition: The transport of organelles or other particles from one location in the cell to another along actin filaments.
synaptic vesicle transport along microtubule (GO:0099517)
Namespace: biological_process
Definition: The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors.
vesicle cytoskeletal trafficking (GO:0099518)
Namespace: biological_process
Definition: The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.
Synonyms: cytoskeletal fiber-based vesicle localization; vesicle cytoskeletal transport
dense core granule cytoskeletal transport (GO:0099519)
Namespace: biological_process
Definition: The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments.
Synonyms: dense core vesicle cytoskeletal trafficking
obsolete ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential (GO:0099521)
Namespace: molecular_function
Definition: OBSOLETE. Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
Synonyms: ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential; ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
cytosolic region (GO:0099522)
Namespace: cellular_component
Definition: Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol.
Synonyms: region of cytosol
presynaptic cytosol (GO:0099523)
Namespace: cellular_component
Definition: The region of the cytosol consisting of all cytosol that is part of the presynapse.
postsynaptic cytosol (GO:0099524)
Namespace: cellular_component
Definition: The region of the cytosol consisting of all cytosol that is part of the postsynapse.
presynaptic dense core vesicle exocytosis (GO:0099525)
Namespace: biological_process
Definition: The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
presynapse to nucleus signaling pathway (GO:0099526)
Namespace: biological_process
Definition: The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
Synonyms: presynaptic signaling to nucleus
Comment: This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term.
postsynapse to nucleus signaling pathway (GO:0099527)
Namespace: biological_process
Definition: The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
Synonyms: postsynaptic signaling to nucleus
G protein-coupled neurotransmitter receptor activity (GO:0099528)
Namespace: molecular_function
Definition: Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G-protein coupled neurotransmitter receptor activity
obsolete neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (GO:0099529)
Namespace: molecular_function
Definition: OBSOLETE. Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel).
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential (GO:0099530)
Namespace: molecular_function
Definition: A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.
Synonyms: G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential
obsolete presynaptic process involved in chemical synaptic transmission (GO:0099531)
Namespace: biological_process
Definition: OBSOLETE. The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
synaptic vesicle endosomal processing (GO:0099532)
Namespace: biological_process
Definition: The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
Synonyms: synaptic vesicle processing via endosome
Comment: This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.
positive regulation of presynaptic cytosolic calcium concentration (GO:0099533)
Namespace: biological_process
Definition: Any process that increases the concentration of calcium ions in the presynaptic cytosol.
calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration (GO:0099534)
Namespace: molecular_function
Definition: The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.
Synonyms: calcium ion binding involved in regulation of presynaptic cytosolic calcium levels; presynaptic calcium ion buffering; regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering
synapse-associated extracellular matrix (GO:0099535)
Namespace: cellular_component
Definition: The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
Synonyms: extra-synaptic extracellular matrix; synapse-associated ECM
synaptic signaling (GO:0099536)
Namespace: biological_process
Definition: Cell-cell signaling to, from or within a synapse.
trans-synaptic signaling (GO:0099537)
Namespace: biological_process
Definition: Cell-cell signaling in either direction across the synaptic cleft.
synaptic signaling via neuropeptide (GO:0099538)
Namespace: biological_process
Definition: Cell-cell signaling to or from a synapse, mediated by a peptide.
neuropeptide secretion from presynapse (GO:0099539)
Namespace: biological_process
Definition: The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration.
Synonyms: neuropeptide secretion from presynapse via dense core granule exocytosis
trans-synaptic signaling by neuropeptide (GO:0099540)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.
trans-synaptic signaling by lipid (GO:0099541)
Namespace: biological_process
Definition: Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.
trans-synaptic signaling by endocannabinoid (GO:0099542)
Namespace: biological_process
Definition: Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand.
trans-synaptic signaling by soluble gas (GO:0099543)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft.
trans-synaptic signaling by trans-synaptic complex (GO:0099545)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
protein catabolic process, modulating synaptic transmission (GO:0099546)
Namespace: biological_process
Definition: Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by nitric oxide (GO:0099548)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide.
trans-synaptic signaling by carbon monoxide (GO:0099549)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide.
trans-synaptic signaling, modulating synaptic transmission (GO:0099550)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by neuropeptide, modulating synaptic transmission (GO:0099551)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by lipid, modulating synaptic transmission (GO:0099552)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (GO:0099553)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by soluble gas, modulating synaptic transmission (GO:0099554)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by nitric oxide, modulating synaptic transmission (GO:0099555)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by carbon monoxide, modulating synaptic transmission (GO:0099556)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission (GO:0099557)
Namespace: biological_process
Definition: Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
maintenance of synapse structure (GO:0099558)
Namespace: biological_process
Definition: A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds.
Synonyms: synaptic maintenance
maintenance of alignment of postsynaptic density and presynaptic active zone (GO:0099559)
Namespace: biological_process
Definition: The process by which alignment between postsynaptic density and presynaptic active zone is maintained.
synaptic membrane adhesion (GO:0099560)
Namespace: biological_process
Definition: The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
Synonyms: synapse adhesion between pre- and post-synapse
synaptic membrane adhesion to extracellular matrix (GO:0099561)
Namespace: biological_process
Definition: The binding of a synaptic membrane to the extracellular matrix via adhesion molecules.
maintenance of postsynaptic density structure (GO:0099562)
Namespace: biological_process
Definition: A process which maintains the organization and the arrangement of proteins in the presynaptic density.
modification of synaptic structure (GO:0099563)
Namespace: biological_process
Definition: Any process that modifies the structure/morphology of a synapse.
Synonyms: synapse remodelling
Comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
modification of synaptic structure, modulating synaptic transmission (GO:0099564)
Namespace: biological_process
Definition: Any process that modulates synaptic transmission via modification of the structure of the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
chemical synaptic transmission, postsynaptic (GO:0099565)
Namespace: biological_process
Definition: The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.
Synonyms: postsynaptic process involved in chemical synaptic transmission
regulation of postsynaptic cytosolic calcium ion concentration (GO:0099566)
Namespace: biological_process
Definition: Any process that regulates the concentration of calcium in the postsynaptic cytosol.
Synonyms: regulation of postsynaptic cytosolic calcium levels
calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration (GO:0099567)
Namespace: molecular_function
Definition: The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.
Synonyms: calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels; postsynaptic calcium ion buffering; regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering
cytoplasmic region (GO:0099568)
Namespace: cellular_component
Definition: Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.
presynaptic cytoskeleton (GO:0099569)
Namespace: cellular_component
Definition: The portion of the cytoskeleton contained within the presynapse.
postsynaptic cytoskeleton (GO:0099571)
Namespace: cellular_component
Definition: The portion of the cytoskeleton contained within the postsynapse.
postsynaptic specialization (GO:0099572)
Namespace: cellular_component
Definition: A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
glutamatergic postsynaptic density (GO:0099573)
Namespace: cellular_component
Definition: The post-synaptic specialization of a glutamatergic excitatory synapse.
Synonyms: postsynaptic specialization, glutamatergic neuron-to-neuron synapse
regulation of protein catabolic process at synapse, modulating synaptic transmission (GO:0099574)
Namespace: biological_process
Definition: Any process that modulates synaptic transmission by regulating protein degradation at the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of protein catabolic process at presynapse, modulating synaptic transmission (GO:0099575)
Namespace: biological_process
Definition: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at presynapse, modulating synaptic transmission (GO:0099577)
Namespace: biological_process
Definition: Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at postsynapse, modulating synaptic transmission (GO:0099578)
Namespace: biological_process
Definition: Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
obsolete G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (GO:0099579)
Namespace: molecular_function
Definition: OBSOLETE. A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.
Synonyms: G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
obsolete monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential (GO:0099580)
Namespace: molecular_function
Definition: OBSOLETE. Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
Synonyms: ion antiporter activity involved in regulation of post-synaptic membrane potential; ion antiporter activity involved in regulation of postsynaptic membrane potential
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential (GO:0099581)
Namespace: molecular_function
Definition: OBSOLETE. Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
Synonyms: ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential; ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
obsolete neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration (GO:0099582)
Namespace: molecular_function
Definition: OBSOLETE. Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol.
Synonyms: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration (GO:0099583)
Namespace: molecular_function
Definition: OBSOLETE. Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.
Synonyms: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
release of sequestered calcium ion into presynaptic cytosol (GO:0099585)
Namespace: biological_process
Definition: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol.
release of sequestered calcium ion into postsynaptic cytosol (GO:0099586)
Namespace: biological_process
Definition: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol.
inorganic ion import across plasma membrane (GO:0099587)
Namespace: biological_process
Definition: The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol.
Synonyms: inorganic ion import into cell
positive regulation of postsynaptic cytosolic calcium concentration (GO:0099588)
Namespace: biological_process
Definition: Any process that increases the concentration of calcium ions in the postsynaptic cytosol.