LiteFold/GO huggingface dataset:
Spemann organizer formation at the anterior end of the primitive streak (GO:0060064)
Namespace: biological_process
Definition: Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan.
Synonyms: Spemann organizer formation in amniotes; Spemann's organizer formation at the anterior end of the primitive streak; Spemann-Mangold organizer formation at the anterior end of the primitive streak
Comment: Occurs in reptiles, birds and mammals.
uterus development (GO:0060065)
Namespace: biological_process
Definition: The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.
Synonyms: Mullerian tract development
cervix development (GO:0060067)
Namespace: biological_process
Definition: The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure.
Synonyms: Mullerian tract development
vagina development (GO:0060068)
Namespace: biological_process
Definition: The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.
Wnt signaling pathway, regulating spindle positioning (GO:0060069)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle.
Synonyms: non-canonical Wnt signaling pathway; Wnt receptor signaling pathway, regulating spindle positioning; Wnt receptor signalling pathway, regulating spindle positioning; Wnt-activated signaling pathway, regulating spindle positioning
canonical Wnt signaling pathway (GO:0060070)
Namespace: biological_process
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Synonyms: canonical Wnt receptor signaling pathway; canonical Wnt-activated signaling pathway; frizzled-1 receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway via beta-catenin; Wnt receptor signalling pathway through beta-catenin
Wnt signaling pathway, planar cell polarity pathway (GO:0060071)
Namespace: biological_process
Definition: A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton.
Synonyms: non-canonical Wnt signaling pathway; PCP pathway; planar cell polarity pathway; Wnt receptor signaling pathway, planar cell polarity pathway; Wnt receptor signalling pathway, planar cell polarity pathway; Wnt-activated signaling pathway, planar cell polarity pathway; Wnt-JNK signaling pathway; Wnt-PCP signaling pathway
large conductance calcium-activated potassium channel activity (GO:0060072)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
Synonyms: BK calcium-activated potassium channel activity; BK channel activity; BK KCa channel activity; large conductance KCa channel activity
micturition (GO:0060073)
Namespace: biological_process
Definition: The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.
Synonyms: urination; urine voiding
synapse maturation (GO:0060074)
Namespace: biological_process
Definition: The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
Synonyms: synaptic maturation
regulation of resting membrane potential (GO:0060075)
Namespace: biological_process
Definition: Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.
Synonyms: regulation of resting potential
excitatory synapse (GO:0060076)
Namespace: cellular_component
Definition: A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
inhibitory synapse (GO:0060077)
Namespace: cellular_component
Definition: A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.
regulation of postsynaptic membrane potential (GO:0060078)
Namespace: biological_process
Definition: Any process that modulates the potential difference across a post-synaptic membrane.
Synonyms: regulation of post-synaptic membrane potential
excitatory postsynaptic potential (GO:0060079)
Namespace: biological_process
Definition: A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
Synonyms: regulation of EPSP; regulation of excitatory post-synaptic membrane potential
inhibitory postsynaptic potential (GO:0060080)
Namespace: biological_process
Definition: A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
Synonyms: IPSP; regulation of inhibitory post-synaptic membrane potential
membrane hyperpolarization (GO:0060081)
Namespace: biological_process
Definition: The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
eye blink reflex (GO:0060082)
Namespace: biological_process
Definition: The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing.
Synonyms: nictitating membrane reflex
smooth muscle contraction involved in micturition (GO:0060083)
Namespace: biological_process
Definition: The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body.
Synonyms: smooth muscle contraction involved in urination; urinary bladder smooth muscle contraction involved in micturition
synaptic transmission involved in micturition (GO:0060084)
Namespace: biological_process
Definition: The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body.
Synonyms: synaptic transmission involved in urination
smooth muscle relaxation of the bladder outlet (GO:0060085)
Namespace: biological_process
Definition: A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body.
Synonyms: synaptic transmission involved in urination
circadian temperature homeostasis (GO:0060086)
Namespace: biological_process
Definition: Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.
Synonyms: circadian regulation of body temperature; circadian thermoregulation
relaxation of vascular associated smooth muscle (GO:0060087)
Namespace: biological_process
Definition: A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.
Synonyms: negative regulation of relaxation of vascular smooth muscle; positive regulation of relaxation of vascular smooth muscle; regulation of relaxation of vascular smooth muscle; relaxation of vascular smooth muscle; vascular smooth muscle relaxation
auditory receptor cell stereocilium organization (GO:0060088)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
Synonyms: auditory receptor cell stereocilium organisation; auditory receptor cell stereocilium organization and biogenesis
molecular transducer activity (GO:0060089)
Namespace: molecular_function
Definition: A compound molecular function in which an effector function is controlled by one or more regulatory components.
molecular adaptor activity (GO:0060090)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
Synonyms: binding, bridging
kinocilium (GO:0060091)
Namespace: cellular_component
Definition: A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.
regulation of synaptic transmission, glycinergic (GO:0060092)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine.
negative regulation of synaptic transmission, glycinergic (GO:0060093)
Namespace: biological_process
Definition: Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine.
Synonyms: negative regulation of glycinergic synaptic transmission
positive regulation of synaptic transmission, glycinergic (GO:0060094)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine.
Synonyms: positive regulation of glycinergic synaptic transmission
zinc potentiation of synaptic transmission, glycinergic (GO:0060095)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine.
Synonyms: zinc potentiation of glycinergic synaptic transmission
serotonin secretion, neurotransmission (GO:0060096)
Namespace: biological_process
Definition: The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter.
Synonyms: serotonin release, neurotransmission
cytoskeletal rearrangement involved in phagocytosis, engulfment (GO:0060097)
Namespace: biological_process
Definition: The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
membrane reorganization involved in phagocytosis, engulfment (GO:0060098)
Namespace: biological_process
Definition: The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
Synonyms: membrane reorganisation involved in phagocytosis, engulfment
regulation of phagocytosis, engulfment (GO:0060099)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
positive regulation of phagocytosis, engulfment (GO:0060100)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
negative regulation of phagocytosis, engulfment (GO:0060101)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
cuticular extracellular matrix (GO:0060102)
Namespace: cellular_component
Definition: A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans.
Synonyms: collagen and cuticulin-based cuticle extracellular matrix; collagen and cuticulin-based exoskeleton extracellular matrix; cuticular ECM
surface coat of collagen and cuticulin-based cuticle extracellular matrix (GO:0060104)
Namespace: cellular_component
Definition: An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans.
Synonyms: surface coat of collagen and cuticulin-based exoskeleton extracellular matrix
epicuticle of collagen and cuticulin-based cuticle extracellular matrix (GO:0060105)
Namespace: cellular_component
Definition: A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans.
Synonyms: epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix
annuli extracellular matrix (GO:0060107)
Namespace: cellular_component
Definition: The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present.
Synonyms: annulae; annular rings; annule(s); annulus
annular furrow extracellular matrix (GO:0060108)
Namespace: cellular_component
Definition: The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline.
medial layer of collagen and cuticulin-based cuticle extracellular matrix (GO:0060109)
Namespace: cellular_component
Definition: The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals.
Synonyms: medial layer struts
basal layer of collagen and cuticulin-based cuticle extracellular matrix (GO:0060110)
Namespace: cellular_component
Definition: The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans.
Synonyms: basal layer of collagen and cuticulin-based exoskeleton extracellular matrix
alae of collagen and cuticulin-based cuticle extracellular matrix (GO:0060111)
Namespace: cellular_component
Definition: Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively.
Synonyms: alae of collagen and cuticulin-based exoskeleton extracellular matrix
generation of ovulation cycle rhythm (GO:0060112)
Namespace: biological_process
Definition: The process which controls the timing of the type of sexual cycle seen in female mammals.
Synonyms: generation of estrus cycle rhythm; generation of menstrual cycle rhythm; generation of oestrus cycle rhythm
inner ear receptor cell differentiation (GO:0060113)
Namespace: biological_process
Definition: The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound.
Synonyms: inner ear hair cell differentiation
vestibular receptor cell differentiation (GO:0060114)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell.
Synonyms: vestibular hair cell differentiation
vestibular receptor cell fate commitment (GO:0060115)
Namespace: biological_process
Definition: The process in which a cell becomes committed to become a vestibular receptor cell.
Synonyms: vestibular hair cell fate commitment
vestibular receptor cell morphogenesis (GO:0060116)
Namespace: biological_process
Definition: Any process that alters the size or shape of a vestibular receptor cell.
Synonyms: vestibular hair cell morphogenesis
auditory receptor cell development (GO:0060117)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
Synonyms: auditory hair cell development
vestibular receptor cell development (GO:0060118)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
Synonyms: vestibular hair cell development
inner ear receptor cell development (GO:0060119)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
Synonyms: inner ear hair cell development
inner ear receptor cell fate commitment (GO:0060120)
Namespace: biological_process
Definition: The process in which a cell becomes committed to become an inner ear receptor cell.
Synonyms: inner ear hair cell fate commitment
vestibular receptor cell stereocilium organization (GO:0060121)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells.
Synonyms: vestibular hair cell stereocilium organization; vestibular receptor cell stereocilium organisation; vestibular receptor cell stereocilium organization and biogenesis
inner ear receptor cell stereocilium organization (GO:0060122)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
Synonyms: inner ear hair cell receptor stereocilium organization; inner ear receptor stereocilium organisation; inner ear receptor stereocilium organization and biogenesis
regulation of growth hormone secretion (GO:0060123)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell.
positive regulation of growth hormone secretion (GO:0060124)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
negative regulation of growth hormone secretion (GO:0060125)
Namespace: biological_process
Definition: Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.
somatotropin secreting cell differentiation (GO:0060126)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.
Synonyms: growth hormone secreting cell differentiation; somatotrope differentiation; somatotroph differentiation; somatotrophin secreting cell differentiation; somatotropic cell differentiation; somatrophic cell differentiation