LiteFold/GO huggingface dataset:
natural killer cell mediated cytotoxicity (GO:0042267)
Namespace: biological_process
Definition: The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Synonyms: killer activity; natural killer cell mediated cell death; natural killer cell mediated cell killing; natural killer cell mediated cytolysis; natural killer-cell mediated cytolysis; NK cell mediated cell death; NK cell mediated cell killing; NK cell mediated cytolysis; NK cell mediated cytotoxicity
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
regulation of cytolysis (GO:0042268)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm.
regulation of natural killer cell mediated cytotoxicity (GO:0042269)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
Synonyms: regulation of natural killer cell mediated cell death; regulation of natural killer cell mediated cell killing; regulation of natural killer cell mediated cytolysis; regulation of natural killer-cell mediated cytolysis; regulation of NK cell mediated cell death; regulation of NK cell mediated cell killing; regulation of NK cell mediated cytolysis; regulation of NK cell mediated cytotoxicity
protection from natural killer cell mediated cytotoxicity (GO:0042270)
Namespace: biological_process
Definition: The process of protecting a cell from natural killer cell mediated cytotoxicity.
Synonyms: protection from natural killer cell mediated cell death; protection from natural killer cell mediated cell killing; protection from natural killer cell mediated cytolysis; protection from NK cell mediated cell death; protection from NK cell mediated cell killing; protection from NK cell mediated cytolysis; protection from NK cell mediated cytotoxicity
susceptibility to natural killer cell mediated cytotoxicity (GO:0042271)
Namespace: biological_process
Definition: The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.
Synonyms: susceptibility to natural killer cell mediated cell death; susceptibility to natural killer cell mediated cell killing; susceptibility to natural killer cell mediated cytolysis; susceptibility to NK cell mediated cell death; susceptibility to NK cell mediated cell killing; susceptibility to NK cell mediated cytolysis; susceptibility to NK cell mediated cytotoxicity
Comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity.
nuclear RNA export factor complex (GO:0042272)
Namespace: cellular_component
Definition: A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm.
Synonyms: Mex67-Mtr2 complex; NXF1-NXT1 complex; TAP-p15 complex
ribosomal large subunit biogenesis (GO:0042273)
Namespace: biological_process
Definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
Synonyms: ribosomal large subunit biogenesis and assembly
ribosomal small subunit biogenesis (GO:0042274)
Namespace: biological_process
Definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
Synonyms: ribosomal small subunit biogenesis and assembly
error-free postreplication DNA repair (GO:0042275)
Namespace: biological_process
Definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate.
Synonyms: error-free PRR; error-free replication restart
Comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
error-prone translesion synthesis (GO:0042276)
Namespace: biological_process
Definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.
Synonyms: error-prone postreplication DNA repair; mutagenic postreplication DNA repair; mutagenic PRR
peptide binding (GO:0042277)
Namespace: molecular_function
Definition: Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
purine nucleoside metabolic process (GO:0042278)
Namespace: biological_process
Definition: The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
Synonyms: purine metabolic process; purine metabolism; purine nucleoside metabolism
nitrite reductase (cytochrome, ammonia-forming) activity (GO:0042279)
Namespace: molecular_function
Definition: Catalysis of the reaction: 6 Fe(III)-[cytochrome c] + NH4+ + 2 H2O = 6 Fe(II)-[cytochrome c] + nitrite + 8 H+.
Synonyms: ammonia:ferricytochrome-c oxidoreductase activity; cytochrome c nitrite reductase activity; cytochrome c552 activity; multiheme nitrite reductase activity; nitrite reductase (cytochrome; ammonia-forming)
obsolete cell surface antigen activity, host-interacting (GO:0042280)
Namespace: molecular_function
Definition: OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition.
Synonyms: cell surface antigen activity, host-interacting
Comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity (GO:0042281)
Namespace: molecular_function
Definition: Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
Synonyms: dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity (GO:0042283)
Namespace: molecular_function
Definition: Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
Synonyms: dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity
xylosyltransferase activity (GO:0042285)
Namespace: molecular_function
Definition: Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
glutamate-1-semialdehyde 2,1-aminomutase activity (GO:0042286)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
Synonyms: (S)-4-amino-5-oxopentanoate 4,5-aminomutase activity; glutamate-1-semialdehyde aminotransferase activity
MHC protein binding (GO:0042287)
Namespace: molecular_function
Definition: Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
Synonyms: major histocompatibility complex binding; major histocompatibility complex ligand
Comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children.
MHC class I protein binding (GO:0042288)
Namespace: molecular_function
Definition: Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
Synonyms: alpha-beta T cell receptor activity; gamma-delta T cell receptor activity; major histocompatibility complex class I binding; major histocompatibility complex class I ligand; T cell receptor activity
Comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
MHC class II protein binding (GO:0042289)
Namespace: molecular_function
Definition: Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
Synonyms: major histocompatibility complex class II binding; major histocompatibility complex class II ligand
Comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
obsolete Hub1 hydrolase activity (GO:0042291)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: Hub1 hydrolase activity
Comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
URM1 activating enzyme activity (GO:0042292)
Namespace: molecular_function
Definition: Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond.
Hub1 activating enzyme activity (GO:0042293)
Namespace: molecular_function
Definition: Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond.
URM1 transferase activity (GO:0042294)
Namespace: molecular_function
Definition: Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages.
ISG15 transferase activity (GO:0042296)
Namespace: molecular_function
Definition: Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.
Synonyms: ISG15 conjugating enzyme activity
vocal learning (GO:0042297)
Namespace: biological_process
Definition: A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.
Comment: Examples include language learning by human infants and song learning in zebra finches.
lupeol synthase activity (GO:0042299)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol.
Synonyms: oxidosqualene:lupeol cyclase activity
beta-amyrin synthase activity (GO:0042300)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin.
Synonyms: 2,3-oxidosqualene beta-amyrin cyclase; oxidosqualene:beta-amyrin cyclase activity
phosphate ion binding (GO:0042301)
Namespace: molecular_function
Definition: Binding to a phosphate ion.
structural constituent of cuticle (GO:0042302)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a cuticle.
molting cycle (GO:0042303)
Namespace: biological_process
Definition: The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc.
regulation of fatty acid biosynthetic process (GO:0042304)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.
Synonyms: regulation of fatty acid anabolism; regulation of fatty acid biosynthesis; regulation of fatty acid formation; regulation of fatty acid synthesis
specification of segmental identity, mandibular segment (GO:0042305)
Namespace: biological_process
Definition: The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
Comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'.
regulation of protein import into nucleus (GO:0042306)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
Synonyms: regulation of protein import into cell nucleus; regulation of protein transport from cytoplasm to nucleus; regulation of protein-nucleus import
positive regulation of protein import into nucleus (GO:0042307)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
Synonyms: activation of protein import into nucleus; positive regulation of protein import into cell nucleus; positive regulation of protein transport from cytoplasm to nucleus; positive regulation of protein-nucleus import; stimulation of protein import into nucleus; up regulation of protein import into nucleus; up-regulation of protein import into nucleus; upregulation of protein import into nucleus
negative regulation of protein import into nucleus (GO:0042308)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
Synonyms: down regulation of protein import into nucleus; down-regulation of protein import into nucleus; downregulation of protein import into nucleus; inhibition of protein import into nucleus; negative regulation of protein import into cell nucleus; negative regulation of protein transport from cytoplasm to nucleus; negative regulation of protein-nucleus import
homoiothermy (GO:0042309)
Namespace: biological_process
Definition: Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment.
Synonyms: antifreeze activity; ice nucleation activity; ice nucleation inhibitor activity
vasoconstriction (GO:0042310)
Namespace: biological_process
Definition: A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure.
Synonyms: negative regulation of blood vessel size
vasodilation (GO:0042311)
Namespace: biological_process
Definition: An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure.
Synonyms: positive regulation of blood vessel size; vasodilatation
protein kinase C deactivation (GO:0042313)
Namespace: biological_process
Definition: Any process resulting in the inhibition or termination of the activity of protein kinase C.
Synonyms: PKC deactivation
bacteriochlorophyll binding (GO:0042314)
Namespace: molecular_function
Definition: Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants.
penicillin metabolic process (GO:0042316)
Namespace: biological_process
Definition: The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus.
Synonyms: penicillin metabolism
penicillin catabolic process (GO:0042317)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
Synonyms: penicillin breakdown; penicillin catabolism; penicillin degradation
penicillin biosynthetic process (GO:0042318)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
Synonyms: penicillin anabolism; penicillin biosynthesis; penicillin formation; penicillin synthesis
regulation of circadian sleep/wake cycle, REM sleep (GO:0042320)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.
Synonyms: regulation of REM sleep
negative regulation of circadian sleep/wake cycle, sleep (GO:0042321)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
Synonyms: down regulation of circadian sleep/wake cycle, sleep; down-regulation of circadian sleep/wake cycle, sleep; downregulation of circadian sleep/wake cycle, sleep; inhibition of circadian sleep/wake cycle, sleep; negative regulation of sleep
negative regulation of circadian sleep/wake cycle, REM sleep (GO:0042322)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.
Synonyms: down regulation of circadian sleep/wake cycle, REM sleep; down-regulation of circadian sleep/wake cycle, REM sleep; downregulation of circadian sleep/wake cycle, REM sleep; inhibition of circadian sleep/wake cycle, REM sleep; negative regulation of REM sleep
negative regulation of circadian sleep/wake cycle, non-REM sleep (GO:0042323)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.
Synonyms: down regulation of circadian sleep/wake cycle, non-REM sleep; down-regulation of circadian sleep/wake cycle, non-REM sleep; downregulation of circadian sleep/wake cycle, non-REM sleep; inhibition of circadian sleep/wake cycle, non-REM sleep; negative regulation of non-REM sleep
orexin receptor binding (GO:0042324)
Namespace: molecular_function
Definition: Binding to an orexin receptor.
Synonyms: hypocretin receptor binding; hypocretin receptor ligand; orexin receptor ligand
regulation of phosphorylation (GO:0042325)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
positive regulation of phosphorylation (GO:0042327)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
Synonyms: activation of phosphorylation; stimulation of phosphorylation; up regulation of phosphorylation; up-regulation of phosphorylation; upregulation of phosphorylation
heparan sulfate N-acetylglucosaminyltransferase activity (GO:0042328)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.
Synonyms: heparan sulphate N-acetylglucosaminyltransferase activity; heparin N-acetylglucosaminyltransferase activity
structural constituent of collagen and cuticulin-based cuticle (GO:0042329)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans.
Synonyms: structural constituent of cuticle
taxis (GO:0042330)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism in response to an external stimulus.
Synonyms: directed movement in response to stimulus
phototaxis (GO:0042331)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism in response to light.
Synonyms: phototactic behavior; phototactic behaviour; taxis in response to light
gravitaxis (GO:0042332)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism in response to gravity.
Synonyms: geotactic behavior; geotactic behaviour; geotaxis; gravitactic behavior; gravitactic behaviour; taxis in response to gravitational stimulus; taxis in response to gravity
chemotaxis to oxidizable substrate (GO:0042333)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose.
Synonyms: taxis in response to oxidizable substrate
taxis to electron acceptor (GO:0042334)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate.
Synonyms: taxis in response to electron acceptor
cuticle development (GO:0042335)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
Synonyms: cuticle anabolism; cuticle biosynthesis; cuticle biosynthetic process; cuticle formation; cuticle synthesis
obsolete cuticle development involved in protein-based cuticle molting cycle (GO:0042336)
Namespace: biological_process
Definition: OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species.
Synonyms: cuticle anabolism during molting; cuticle biosynthetic process during molting; cuticle development involved in protein-based cuticle molting cycle; cuticle formation during molting; cuticle synthesis during molting
Comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.