LiteFold/GO huggingface dataset:
LUBAC complex (GO:0071797)
Namespace: cellular_component
Definition: A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.
response to prostaglandin D (GO:0071798)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.
Synonyms: response to prostaglandin D stimulus
cellular response to prostaglandin D stimulus (GO:0071799)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.
podosome assembly (GO:0071800)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell.
regulation of podosome assembly (GO:0071801)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of podosome assembly.
Comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
negative regulation of podosome assembly (GO:0071802)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of podosome assembly.
Synonyms: down regulation of podosome assembly; down-regulation of podosome assembly; downregulation of podosome assembly; inhibition of podosome assembly
potassium ion transmembrane transport (GO:0071805)
Namespace: biological_process
Definition: A process in which a potassium ion is transported from one side of a membrane to the other.
Synonyms: high affinity potassium ion import; high affinity potassium ion uptake; high-affinity potassium ion import; high-affinity potassium ion uptake; potassium ion membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
protein transmembrane transport (GO:0071806)
Namespace: biological_process
Definition: The process in which a protein is transported across a membrane.
Synonyms: protein membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
replication fork arrest involved in DNA replication termination (GO:0071807)
Namespace: biological_process
Definition: A replication fork arrest process that contributes to the termination of DNA replication.
satellite fibril (GO:0071808)
Namespace: cellular_component
Definition: An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section).
regulation of fever generation by regulation of prostaglandin biosynthesis (GO:0071809)
Namespace: biological_process
Definition: Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.
regulation of fever generation by regulation of prostaglandin secretion (GO:0071810)
Namespace: biological_process
Definition: Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell.
positive regulation of fever generation by positive regulation of prostaglandin biosynthesis (GO:0071811)
Namespace: biological_process
Definition: Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.
positive regulation of fever generation by positive regulation of prostaglandin secretion (GO:0071812)
Namespace: biological_process
Definition: Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell.
lipoprotein particle binding (GO:0071813)
Namespace: molecular_function
Definition: Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
Synonyms: lipoprotein binding; plasma lipoprotein binding; plasma lipoprotein particle binding
protein-lipid complex binding (GO:0071814)
Namespace: molecular_function
Definition: Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules.
intermediate-density lipoprotein particle binding (GO:0071815)
Namespace: molecular_function
Definition: Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm.
Synonyms: IDL binding; intermediate-density lipoprotein binding
tail-anchored membrane protein insertion into ER membrane (GO:0071816)
Namespace: biological_process
Definition: A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.
Synonyms: protein insertion of tail-anchored membrane proteins into ER membrane; tail-anchored membrane protein insertion into endoplasmic reticulum membrane; type II transmembrane protein insertion into ER membrane
MMXD complex (GO:0071817)
Namespace: cellular_component
Definition: A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation.
Synonyms: MMS19-MIP18-XPD complex
DUBm complex (GO:0071819)
Namespace: cellular_component
Definition: A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p.
Synonyms: deubiquitinating module; deubiquitination module; SAGA DUBm complex
N-box binding (GO:0071820)
Namespace: molecular_function
Definition: Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.
Synonyms: N box binding; N-box promoter binding
FANCM-MHF complex (GO:0071821)
Namespace: cellular_component
Definition: A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.
protein-carbohydrate complex subunit organization (GO:0071823)
Namespace: biological_process
Definition: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex.
Synonyms: protein-carbohydrate complex subunit organisation
protein-DNA complex organization (GO:0071824)
Namespace: biological_process
Definition: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.
Synonyms: DNA-protein complex subunit organization; protein-DNA complex subunit organisation; protein-DNA complex subunit organization
protein-RNA complex organization (GO:0071826)
Namespace: biological_process
Definition: Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.
Synonyms: protein-RNA complex subunit organization; ribonucleoprotein complex subunit organisation; ribonucleoprotein complex subunit organization; RNA-protein complex subunit organization
plasma lipoprotein particle organization (GO:0071827)
Namespace: biological_process
Definition: A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins.
Synonyms: plasma lipoprotein particle organisation
apolipoprotein E recycling (GO:0071828)
Namespace: biological_process
Definition: The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle.
Synonyms: APOE recycling
plasma lipoprotein particle disassembly (GO:0071829)
Namespace: biological_process
Definition: The disaggregation of a plasma lipoprotein particle into its constituent components.
triglyceride-rich lipoprotein particle clearance (GO:0071830)
Namespace: biological_process
Definition: The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
intermediate-density lipoprotein particle clearance (GO:0071831)
Namespace: biological_process
Definition: The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
Synonyms: IDL clearance
mating pheromone secretion (GO:0071834)
Namespace: biological_process
Definition: The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction.
Synonyms: mating-type pheromone secretion
obsolete mating pheromone secretion involved in regulation of conjugation with cellular fusion (GO:0071835)
Namespace: biological_process
Definition: OBSOLETE. The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that regulates the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms.
Synonyms: mating pheromone secretion involved in regulation of conjugation; mating-type pheromone secretion involved in conjugation; peptide pheromone export involved in regulation of conjugation
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
nectar secretion (GO:0071836)
Namespace: biological_process
Definition: The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins.
Synonyms: nectar production
HMG box domain binding (GO:0071837)
Namespace: molecular_function
Definition: Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
cell proliferation in bone marrow (GO:0071838)
Namespace: biological_process
Definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow.
Synonyms: bone marrow cell proliferation
apoptotic process in bone marrow cell (GO:0071839)
Namespace: biological_process
Definition: The apoptotic process in cells in the bone marrow.
Synonyms: apoptosis in bone marrow; bone marrow cell apoptosis; bone marrow cell programmed cell death by apoptosis; killing of bone marrow cells; programmed cell death of bone marrow cells by apoptosis; programmed cell death, bone marrow cells
cellular component organization or biogenesis (GO:0071840)
Namespace: biological_process
Definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
Synonyms: cellular component organisation or biogenesis; cellular component organisation or biogenesis at cellular level; cellular component organization or biogenesis at cellular level
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
actin filament debranching (GO:0071846)
Namespace: biological_process
Definition: An actin filament severing process that results in the removal of actin filament branches specifically at the branch points.
obsolete TNFSF11-mediated signaling pathway (GO:0071847)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: RANKL-mediated signaling pathway; receptor activator of nuclear factor kappa-B ligand signaling pathway; TNF-related activation-induced cytokine-mediated signaling pathway; TNFSF11-mediated signalling pathway; tumor necrosis factor superfamily member 11-mediated signaling pathway
Comment: This term was obsoleted because it represents a specific ligand of the tumor necrosis factor-mediated signaling pathway ; GO:0033209.
obsolete positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling (GO:0071848)
Namespace: biological_process
Definition: OBSOLETE. Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade.
Synonyms: positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling
Comment: This term was obsoleted because it represents specific steps in the tumor necrosis factor-mediated signaling pathway ; GO:0033209.
obsolete G1 cell cycle arrest in response to nitrogen starvation (GO:0071849)
Namespace: biological_process
Definition: OBSOLETE. The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen.
Comment: This term was obsoleted because it does not represent a specific process.
obsolete mitotic G1 cell cycle arrest in response to nitrogen starvation (GO:0071851)
Namespace: biological_process
Definition: OBSOLETE. The process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen.
Synonyms: G1 mitotic cell cycle arrest in response to nitrogen starvation
Comment: This term was obsoleted because it does not represent a specific process.
fungal-type cell wall disassembly (GO:0071853)
Namespace: biological_process
Definition: A cellular process that results in the breakdown of a fungal-type cell wall.
obsolete cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly (GO:0071854)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
beta-endorphin receptor binding (GO:0071857)
Namespace: molecular_function
Definition: Binding to a beta-endorphin receptor.
corazonin receptor binding (GO:0071858)
Namespace: molecular_function
Definition: Binding to a corazonin receptor.
neuropeptide F receptor binding (GO:0071859)
Namespace: molecular_function
Definition: Binding to a neuropeptide F receptor.
proctolin receptor binding (GO:0071860)
Namespace: molecular_function
Definition: Binding to a proctolin receptor.
tachykinin receptor binding (GO:0071861)
Namespace: molecular_function
Definition: Binding to a tachykinin receptor.
regulation of cell proliferation in bone marrow (GO:0071863)
Namespace: biological_process
Definition: A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow.
Synonyms: regulation of bone marrow cell proliferation
positive regulation of cell proliferation in bone marrow (GO:0071864)
Namespace: biological_process
Definition: A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.
Synonyms: activation of cell proliferation in bone marrow; positive regulation of bone marrow cell proliferation; stimulation of cell proliferation in bone marrow; up regulation of cell proliferation in bone marrow; up-regulation of cell proliferation in bone marrow; upregulation of cell proliferation in bone marrow
regulation of apoptotic process in bone marrow cell (GO:0071865)
Namespace: biological_process
Definition: Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow.
Synonyms: regulation of apoptosis in bone marrow; regulation of apoptotic process in bone marrow
negative regulation of apoptotic process in bone marrow cell (GO:0071866)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow.
Synonyms: down regulation of apoptosis in bone marrow; down-regulation of apoptosis in bone marrow; downregulation of apoptosis in bone marrow; inhibition of apoptosis in bone marrow; negative regulation of apoptosis in bone marrow; negative regulation of apoptotic process in bone marrow; negative regulation of bone marrow cell apoptosis; negative regulation of bone marrow cell programmed cell death by apoptosis; negative regulation of killing of bone marrow cells; negative regulation of programmed cell death of bone marrow cells by apoptosis; negative regulation of programmed cell death, bone marrow cells
cellular response to monoamine stimulus (GO:0071868)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.
response to catecholamine (GO:0071869)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.
Synonyms: response to catecholamine stimulus
cellular response to catecholamine stimulus (GO:0071870)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.
cellular response to epinephrine stimulus (GO:0071872)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
Synonyms: cellular response to adrenaline stimulus
Comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
response to norepinephrine (GO:0071873)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.
Synonyms: response to noradrenaline stimulus; response to norepinephrine stimulus
Comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
cellular response to norepinephrine stimulus (GO:0071874)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.
Synonyms: cellular response to noradrenaline stimulus
Comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
adrenergic receptor signaling pathway (GO:0071875)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: adrenergic receptor signalling pathway; adrenoceptor signaling pathway
obsolete initiation of adrenergic receptor signal transduction (GO:0071876)
Namespace: biological_process
Definition: OBSOLETE. A process of signal initiation in which epinephrine or norepinephrine causes activation of an adrenergic receptor.
Synonyms: initiation of adrenergic receptor signal transduction
Comment: This term was made obsolete because the meaning of the term is ambiguous.
regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway (GO:0071877)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.
Synonyms: regulation of adrenergic receptor signaling pathway; regulation of adrenergic receptor signalling pathway
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (GO:0071878)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.
Synonyms: negative regulation of adrenergic receptor signaling pathway; negative regulation of adrenergic receptor signalling pathway