LiteFold/GO huggingface dataset:
insulin-like growth factor binary complex (GO:0042568)
Namespace: cellular_component
Definition: A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development.
Synonyms: IGF binary complex
immunoglobulin complex, circulating (GO:0042571)
Namespace: cellular_component
Definition: An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
Synonyms: antibody
Comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
retinol metabolic process (GO:0042572)
Namespace: biological_process
Definition: The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
Synonyms: retinol metabolism; vitamin A1 alcohol metabolic process; vitamin A1 alcohol metabolism; vitamin A1 metabolic process; vitamin A1 metabolism
retinoic acid metabolic process (GO:0042573)
Namespace: biological_process
Definition: The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
Synonyms: retinoic acid metabolism; vitamin A1 acid metabolic process; vitamin A1 acid metabolism
retinal metabolic process (GO:0042574)
Namespace: biological_process
Definition: The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
Synonyms: retinal metabolism; retinaldehyde metabolic process; retinaldehyde metabolism
DNA polymerase complex (GO:0042575)
Namespace: cellular_component
Definition: A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA.
obsolete aspartyl aminopeptidase activity (GO:0042576)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
Synonyms: aspartyl aminopeptidase activity
Comment: This term was made obsolete because it represents a gene product.
lipid phosphatase activity (GO:0042577)
Namespace: molecular_function
Definition: Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.
phosphoric ester hydrolase activity (GO:0042578)
Namespace: molecular_function
Definition: Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.
microbody (GO:0042579)
Namespace: cellular_component
Definition: Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
mannosome (GO:0042580)
Namespace: cellular_component
Definition: A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction.
specific granule (GO:0042581)
Namespace: cellular_component
Definition: Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
Synonyms: secondary granule
azurophil granule (GO:0042582)
Namespace: cellular_component
Definition: Primary lysosomal granule readily stainable with a Romanowsky stain.
Synonyms: primary granule
chromaffin granule (GO:0042583)
Namespace: cellular_component
Definition: Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.
chromaffin granule membrane (GO:0042584)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.
germinal vesicle (GO:0042585)
Namespace: cellular_component
Definition: The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.
Synonyms: primary oocyte nucleus
peptide deformylase activity (GO:0042586)
Namespace: molecular_function
Definition: Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide.
Synonyms: formyl-L-methionyl peptide amidohydrolase activity; PDF activity; polypeptide deformylase activity
glycogen granule (GO:0042587)
Namespace: cellular_component
Definition: Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.
Synonyms: glycogen particle
zymogen granule (GO:0042588)
Namespace: cellular_component
Definition: A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.
zymogen granule membrane (GO:0042589)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a zymogen granule.
homeostatic process (GO:0042592)
Namespace: biological_process
Definition: Any biological process involved in the maintenance of an internal steady state. Homeostasis allows cells and organisms to maintain stable internal conditions despite varying external conditions.
Synonyms: activation of homeostatic process; homeostasis; inhibition of homeostatic process; negative regulation of homeostatic process; positive regulation of homeostatic process; regulation of homeostatic process
glucose homeostasis (GO:0042593)
Namespace: biological_process
Definition: Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
behavioral response to starvation (GO:0042595)
Namespace: biological_process
Definition: Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.
Synonyms: behavioural response to starvation
fear response (GO:0042596)
Namespace: biological_process
Definition: The response of an organism to a perceived external threat.
Synonyms: physiological fear response
periplasmic space (GO:0042597)
Namespace: cellular_component
Definition: The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
Synonyms: periplasm
obsolete vesicular fraction (GO:0042598)
Namespace: cellular_component
Definition: OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized.
Synonyms: vesicular fraction
Comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
lamellar body (GO:0042599)
Namespace: cellular_component
Definition: A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.
Synonyms: keratinosome; lamellar granule; membrane-coating granule; Odland body
endospore-forming forespore (GO:0042601)
Namespace: cellular_component
Definition: Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions.
riboflavin reductase (NADPH) activity (GO:0042602)
Namespace: molecular_function
Definition: Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.
Synonyms: flavin reductase activity; FMN reductase (NADPH) activity; NADPH dehydrogenase (riboflavin) activity; NADPH-dependent FMN reductase activity; NADPH-FMN reductase activity; NADPH-riboflavin oxidoreductase activity; NADPH-riboflavin reductase activity; NADPH-specific FMN reductase activity; NADPH:riboflavin oxidoreductase activity; reduced-riboflavin:NADP+ oxidoreductase activity; riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity; riboflavin mononucleotide reductase activity; riboflavine mononucleotide reductase activity
capsule (GO:0042603)
Namespace: cellular_component
Definition: A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherence, and resistance to desiccation.
peptide antigen binding (GO:0042605)
Namespace: molecular_function
Definition: Binding to an antigen peptide.
Synonyms: endogenous peptide antigen binding; exogenous peptide antigen binding
Comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule.
CD4 receptor binding (GO:0042609)
Namespace: molecular_function
Definition: Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
CD8 receptor binding (GO:0042610)
Namespace: molecular_function
Definition: Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.
MHC protein complex (GO:0042611)
Namespace: cellular_component
Definition: A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.
MHC class I protein complex (GO:0042612)
Namespace: cellular_component
Definition: A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.
Comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'.
MHC class II protein complex (GO:0042613)
Namespace: cellular_component
Definition: A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.
CD70 receptor binding (GO:0042614)
Namespace: molecular_function
Definition: Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells.
Synonyms: CD27 receptor activity; CD27L binding
CD154 receptor binding (GO:0042615)
Namespace: molecular_function
Definition: Binding to CD154, a receptor found on the surface of some activated lymphocytes.
Synonyms: CD40 receptor activity; CD40L binding
poly-hydroxybutyrate metabolic process (GO:0042618)
Namespace: biological_process
Definition: The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.
Synonyms: PHB metabolic process; PHB metabolism; poly-hydroxybutyrate metabolism
poly-hydroxybutyrate biosynthetic process (GO:0042619)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.
Synonyms: PHB biosynthesis; PHB biosynthetic process; poly-hydroxybutyrate anabolism; poly-hydroxybutyrate biosynthesis; poly-hydroxybutyrate formation; poly-hydroxybutyrate synthesis
poly(3-hydroxyalkanoate) metabolic process (GO:0042620)
Namespace: biological_process
Definition: The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.
Synonyms: PHA metabolic process; PHA metabolism; poly(3-hydroxyalkanoate) metabolism
poly(3-hydroxyalkanoate) biosynthetic process (GO:0042621)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.
Synonyms: PHA biosynthesis; PHA biosynthetic process; poly(3-hydroxyalkanoate) anabolism; poly(3-hydroxyalkanoate) biosynthesis; poly(3-hydroxyalkanoate) formation; poly(3-hydroxyalkanoate) synthesis
photoreceptor outer segment membrane (GO:0042622)
Namespace: cellular_component
Definition: The membrane surrounding the outer segment of a vertebrate photoreceptor.
obsolete ATPase activity, uncoupled (GO:0042624)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction.
Comment: The reason for obsoletion is that the there is no convincing example of a protein with this function.
ATPase-coupled ion transmembrane transporter activity (GO:0042625)
Namespace: molecular_function
Definition: Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate.
Synonyms: ATP-dependent ion transmembrane transporter activity; ATPase activity, coupled to transmembrane movement of ions; ATPase coupled ion transmembrane transporter activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Namespace: molecular_function
Definition: Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
Synonyms: ATP-coupled transmembrane transporter activity; ATP-dependent transmembrane transporter activity; ATPase activity, coupled to movement of substances; ATPase activity, coupled to transmembrane movement of substances; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; P-P-bond-hydrolysis-driven transmembrane transporter activity; P-P-bond-hydrolysis-driven transporter
chylomicron (GO:0042627)
Namespace: cellular_component
Definition: A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.
mating plug formation (GO:0042628)
Namespace: biological_process
Definition: The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males.
Synonyms: copulatory plug biosynthesis; copulatory plug deposition; copulatory plug formation; mating plug deposition
mast cell granule (GO:0042629)
Namespace: cellular_component
Definition: Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.
behavioral response to water deprivation (GO:0042630)
Namespace: biological_process
Definition: Any process that results in a change in the behavior of an organism as a result of deprivation of water.
Synonyms: behavioral response to drought; behavioral response to thirst; behavioural response to water deprivation
cellular response to water deprivation (GO:0042631)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.
Synonyms: cellular response to drought
cholesterol homeostasis (GO:0042632)
Namespace: biological_process
Definition: Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
Synonyms: positive regulation of cholesterol homeostasis; regulation of cholesterol homeostasis
hair cycle (GO:0042633)
Namespace: biological_process
Definition: The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
regulation of hair cycle (GO:0042634)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
negative regulation of hair cycle (GO:0042636)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
Synonyms: down regulation of hair cycle; down-regulation of hair cycle; downregulation of hair cycle; inhibition of hair cycle
catagen (GO:0042637)
Namespace: biological_process
Definition: The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.
Synonyms: hair regression
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
exogen (GO:0042638)
Namespace: biological_process
Definition: The shedding phase of the hair cycle.
Synonyms: hair shedding
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
telogen (GO:0042639)
Namespace: biological_process
Definition: The resting phase of hair cycle.
Synonyms: hair resting phase
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
anagen (GO:0042640)
Namespace: biological_process
Definition: The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.
Synonyms: hair growth
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
actomyosin (GO:0042641)
Namespace: cellular_component
Definition: Any complex of actin, myosin, and accessory proteins.
Synonyms: actomyosin complex; actomyosin structure
actomyosin, myosin complex part (GO:0042642)
Namespace: cellular_component
Definition: The myosin part of any complex of actin, myosin, and accessory proteins.
obsolete actomyosin, actin portion (GO:0042643)
Namespace: cellular_component
Definition: OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins.
Comment: This term was obsoleted because it corresponds to a gene product, actin.
mitochondrial nucleoid (GO:0042645)
Namespace: cellular_component
Definition: The region of a mitochondrion to which the DNA is confined.
plastid nucleoid (GO:0042646)
Namespace: cellular_component
Definition: The region of a plastid to which the DNA is confined.
proplastid nucleoid (GO:0042647)
Namespace: cellular_component
Definition: The region of a proplastid to which the DNA is confined.
chloroplast chromosome (GO:0042648)
Namespace: cellular_component
Definition: A circular DNA molecule containing chloroplast encoded genes.
prothylakoid (GO:0042649)
Namespace: cellular_component
Definition: Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light.
prothylakoid membrane (GO:0042650)
Namespace: cellular_component
Definition: The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes.
thylakoid membrane (GO:0042651)
Namespace: cellular_component
Definition: The pigmented membrane of any thylakoid.
obsolete mitochondrial respiratory chain complex I, membrane segment (GO:0042653)
Namespace: cellular_component
Definition: OBSOLETE. The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.
Synonyms: NADH-Q oxidoreductase complex, membrane segment
Comment: The reason for obsoletion is that this term represents a sub-complex, out-of-scope for GO.
ecdysis-triggering hormone receptor activity (GO:0042654)
Namespace: molecular_function
Definition: Combining with ecdysis-triggering hormone to initiate a change in cell activity.
Synonyms: ecdysis-triggering hormone binding; ETH receptor
obsolete activation of JNKKK activity (GO:0042655)
Namespace: biological_process
Definition: OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity.
Synonyms: activation of JUN kinase kinase kinase activity; positive regulation of JUNKKK activity
Comment: This term was obsoleted because it represents a molecular function.
JUN kinase kinase kinase kinase activity (GO:0042656)
Namespace: molecular_function
Definition: Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs).
Synonyms: JUNKKKK activity
MHC class II protein binding, via lateral surface (GO:0042657)
Namespace: molecular_function
Definition: Binding to the lateral surface of major histocompatibility complex class II molecules.
Synonyms: major histocompatibility complex class II protein binding, via lateral surface