LiteFold/GO huggingface dataset:
exploration behavior (GO:0035640)
Namespace: biological_process
Definition: The specific behavior of an organism in response to a novel environment or stimulus.
Synonyms: exploration behaviour; exploratory behavior; exploratory behaviour; open-field behavior
Comment: For changes in locomotory behavior upon introduction to a novel environment, consider instead the child term: locomotory exploration behavior ; GO:0035641.
locomotory exploration behavior (GO:0035641)
Namespace: biological_process
Definition: The specific movement from place to place of an organism in response to a novel environment.
histone H3R17 methyltransferase activity (GO:0035642)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to the arginine residue at position 17 of histone H3.
Synonyms: histone methylase activity (H3-R17 specific); histone methyltransferase activity (H3-R17 specific); histone-arginine N-methyltransferase activity (H3-R17 specific); histone-H3R17 methyltransferase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
L-DOPA receptor activity (GO:0035643)
Namespace: molecular_function
Definition: Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine.
Synonyms: L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity
phosphoanandamide dephosphorylation (GO:0035644)
Namespace: biological_process
Definition: The process of removing one or more phosphate groups from a phosphorylated anandamide.
enteric smooth muscle cell differentiation (GO:0035645)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.
Synonyms: intestinal smooth muscle cell differentiation
endosome to melanosome transport (GO:0035646)
Namespace: biological_process
Definition: The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.
obsolete 3-oxo-delta(4,5)-steroid 5-beta-reductase activity (GO:0035647)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H+ = a 5-beta-3-oxo-steroid + NADP+.
Synonyms: 3-oxo-delta4,5-steroid 5beta-reductase
Comment: The reason for obsoletion is that this term is equivalent to GO:0047787 delta4-3-oxosteroid 5beta-reductase activity.
circadian mating behavior (GO:0035648)
Namespace: biological_process
Definition: The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.
Synonyms: circadian mating behaviour; circadian mating rhythm
Nrd1 complex (GO:0035649)
Namespace: cellular_component
Definition: A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.
AP-1 adaptor complex binding (GO:0035650)
Namespace: molecular_function
Definition: Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
AP-3 adaptor complex binding (GO:0035651)
Namespace: molecular_function
Definition: Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).
clathrin-coated vesicle cargo loading (GO:0035652)
Namespace: biological_process
Definition: Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle.
Synonyms: cargo loading into clathrin-coated vesicle
clathrin-coated vesicle cargo loading, AP-1-mediated (GO:0035653)
Namespace: biological_process
Definition: Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking.
Synonyms: cargo loading into clathrin-coated vesicle, AP-1-mediated
clathrin-coated vesicle cargo loading, AP-3-mediated (GO:0035654)
Namespace: biological_process
Definition: Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle.
Synonyms: cargo loading into clathrin-coated vesicle, AP-3-mediated
interleukin-18-mediated signaling pathway (GO:0035655)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: interleukin-18-mediated signalling pathway
obsolete kinesin-associated melanosomal adaptor activity (GO:0035656)
Namespace: molecular_function
Definition: OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes.
Synonyms: kinesin-melanosome adaptor activity
Comment: This term was obsoleted because it represents the function of a specific protein.
eRF1 methyltransferase complex (GO:0035657)
Namespace: cellular_component
Definition: A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.
Synonyms: eRF1 MTase complex
obsolete Wnt signaling pathway involved in wound healing, spreading of epidermal cells (GO:0035659)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis.
Synonyms: Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells; Wnt receptor signalling pathway involved in wound healing, spreading of epidermal cells; Wnt-activated signaling pathway involved in wound healing, spreading of epidermal cells
Comment: This term was obsoleted because it represents a GO-CAM model.
MyD88-dependent toll-like receptor 4 signaling pathway (GO:0035660)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms: MyD88-dependent TLR4 signaling pathway; MyD88-dependent toll-like receptor 4 signalling pathway
MyD88-dependent toll-like receptor 2 signaling pathway (GO:0035661)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response.
Synonyms: MyD88-dependent TLR2 signaling pathway; MyD88-dependent toll-like receptor 2 signalling pathway
Toll-like receptor 4 binding (GO:0035662)
Namespace: molecular_function
Definition: Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms: TLR4 binding
TIRAP-dependent toll-like receptor signaling pathway (GO:0035664)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms: MAL-dependent toll-like receptor signaling pathway; MyD88 adapter-like dependent toll-like receptor signaling pathway; TIRAP-dependent TLR signaling pathway; TIRAP-dependent toll-like receptor signalling pathway
TIRAP-dependent toll-like receptor 4 signaling pathway (GO:0035665)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms: MAL-dependent toll-like receptor 4 signaling pathway; MyD88 adapter-like dependent toll-like receptor 4 signaling pathway; TIRAP-dependent TLR4 signaling pathway; TIRAP-dependent toll-like receptor 4 signalling pathway
TRIF-dependent toll-like receptor signaling pathway (GO:0035666)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms: Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway; TRIF-dependent TLR signaling pathway; TRIF-dependent toll-like receptor signalling pathway
TRIF-dependent toll-like receptor 4 signaling pathway (GO:0035667)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms: Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway; TRIF-dependent TLR4 signaling pathway; TRIF-dependent toll-like receptor 4 signalling pathway
TRAM-dependent toll-like receptor signaling pathway (GO:0035668)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms: TRAM-dependent TLR signaling pathway; TRAM-dependent toll-like receptor signalling pathway
TRAM-dependent toll-like receptor 4 signaling pathway (GO:0035669)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
Synonyms: TRAM-dependent TLR4 signaling pathway; TRAM-dependent toll-like receptor 4 signalling pathway
plant-type ovary development (GO:0035670)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed.
enone reductase activity (GO:0035671)
Namespace: molecular_function
Definition: Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+.
oligopeptide transmembrane transport (GO:0035672)
Namespace: biological_process
Definition: The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
Synonyms: oligopeptide membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
oligopeptide transmembrane transporter activity (GO:0035673)
Namespace: molecular_function
Definition: Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.
Synonyms: oligopeptide transporter activity
tricarboxylic acid transmembrane transport (GO:0035674)
Namespace: biological_process
Definition: The process in which a tricarboxylic acid is transported across a membrane.
Synonyms: tricarboxylic acid membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
neuromast hair cell development (GO:0035675)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.
anterior lateral line neuromast hair cell development (GO:0035676)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.
posterior lateral line neuromast hair cell development (GO:0035677)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.
neuromast hair cell morphogenesis (GO:0035678)
Namespace: biological_process
Definition: The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.
anterior lateral line neuromast hair cell morphogenesis (GO:0035679)
Namespace: biological_process
Definition: The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.
posterior lateral line neuromast hair cell morphogenesis (GO:0035680)
Namespace: biological_process
Definition: The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.
toll-like receptor 15 signaling pathway (GO:0035681)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to toll-like receptor 15.
Synonyms: TLR15 signaling pathway; toll-like receptor 15 signalling pathway
toll-like receptor 21 signaling pathway (GO:0035682)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to toll-like receptor 21.
Synonyms: TLR21 signaling pathway; toll-like receptor 21 signalling pathway
memory T cell extravasation (GO:0035683)
Namespace: biological_process
Definition: The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.
Synonyms: memory T-cell extravasation
helper T cell extravasation (GO:0035684)
Namespace: biological_process
Definition: The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells.
Synonyms: helper T-cell extravasation; T-helper cell extravasation
helper T cell diapedesis (GO:0035685)
Namespace: biological_process
Definition: The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.
Synonyms: helper T-cell diapedesis; T-helper cell diapedesis
sperm fibrous sheath (GO:0035686)
Namespace: cellular_component
Definition: A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.
Synonyms: flagellar fibrous sheath; flagellum fibrous sheath
T-helper 1 cell diapedesis (GO:0035688)
Namespace: biological_process
Definition: The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
Synonyms: Th1 cell diapedesis
chemokine (C-C motif) ligand 5 signaling pathway (GO:0035689)
Namespace: biological_process
Definition: The series of molecular signals initiated by chemokine CCL5 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CCL5-mediated signaling pathway; chemokine (C-C motif) ligand 5 signalling pathway; RANTES-mediated signaling pathway
macrophage migration inhibitory factor signaling pathway (GO:0035691)
Namespace: biological_process
Definition: The series of molecular signals initiated by macrophage migration inhibitory factor binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: macrophage migration inhibitory factor signalling pathway; MIF signaling pathway
macrophage migration inhibitory factor receptor complex (GO:0035692)
Namespace: cellular_component
Definition: A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins.
NOS2-CD74 complex (GO:0035693)
Namespace: cellular_component
Definition: A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases.
mitochondrial protein catabolic process (GO:0035694)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure.
Synonyms: catabolism of mitochondrial protein; degradation of damaged mitochondrial protein
mitophagy by internal vacuole formation (GO:0035695)
Namespace: biological_process
Definition: The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes.
Synonyms: MIV-mediated mitophagy
Comment: In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome.
monocyte extravasation (GO:0035696)
Namespace: biological_process
Definition: The migration of a monocyte from the blood vessels into the surrounding tissue.
CD8-positive, alpha-beta cytotoxic T cell extravasation (GO:0035698)
Namespace: biological_process
Definition: The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue.
T-helper 17 cell extravasation (GO:0035699)
Namespace: biological_process
Definition: The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue.
astrocyte chemotaxis (GO:0035700)
Namespace: biological_process
Definition: The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
monocyte homeostasis (GO:0035702)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
monocyte migration into blood stream (GO:0035703)
Namespace: biological_process
Definition: The movement of a monocyte from the bone marrow to the blood stream.
Synonyms: release of monocytes into circulation
helper T cell chemotaxis (GO:0035704)
Namespace: biological_process
Definition: The directed movement of a helper T cell in response to an external stimulus.
Synonyms: T-helper cell chemotaxis
T-helper 17 cell chemotaxis (GO:0035705)
Namespace: biological_process
Definition: The directed movement of a T-helper 17 cell in response to an external stimulus.
Synonyms: Th17 cell chemotaxis
T-helper 1 cell chemotaxis (GO:0035706)
Namespace: biological_process
Definition: The directed movement of a T-helper 1 cell in response to an external stimulus.
Synonyms: Th1 cell chemotaxis
T-helper 2 cell chemotaxis (GO:0035707)
Namespace: biological_process
Definition: The directed movement of a T-helper 2 cell in response to an external stimulus.
Synonyms: Th2 cell chemotaxis