LiteFold/GO huggingface dataset:
regulation of leukocyte degranulation (GO:0043300)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of leukocyte degranulation.
Synonyms: regulation of immune cell degranulation; regulation of immune cell granule exocytosis; regulation of leucocyte degranulation; regulation of leukocyte granule exocytosis
negative regulation of leukocyte degranulation (GO:0043301)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of leukocyte degranulation.
Synonyms: down regulation of leukocyte degranulation; down-regulation of leukocyte degranulation; downregulation of leukocyte degranulation; inhibition of leukocyte degranulation; negative regulation of immune cell degranulation; negative regulation of leucocyte degranulation
positive regulation of leukocyte degranulation (GO:0043302)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of leukocyte degranulation.
Synonyms: activation of leukocyte degranulation; positive regulation of immune cell degranulation; positive regulation of leucocyte degranulation; stimulation of leukocyte degranulation; up regulation of leukocyte degranulation; up-regulation of leukocyte degranulation; upregulation of leukocyte degranulation
regulation of mast cell degranulation (GO:0043304)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of mast cell degranulation.
Synonyms: regulation of mast cell granule exocytosis
negative regulation of mast cell degranulation (GO:0043305)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of mast cell degranulation.
Synonyms: down regulation of mast cell degranulation; down-regulation of mast cell degranulation; downregulation of mast cell degranulation; inhibition of mast cell degranulation; negative regulation of mast cell granule exocytosis
positive regulation of mast cell degranulation (GO:0043306)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
Synonyms: activation of mast cell degranulation; positive regulation of mast cell granule exocytosis; stimulation of mast cell degranulation; up regulation of mast cell degranulation; up-regulation of mast cell degranulation; upregulation of mast cell degranulation
eosinophil activation (GO:0043307)
Namespace: biological_process
Definition: The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
eosinophil degranulation (GO:0043308)
Namespace: biological_process
Definition: The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil.
Synonyms: eosinophil granule exocytosis
regulation of eosinophil degranulation (GO:0043309)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of eosinophil degranulation.
Synonyms: regulation of eosinophil granule exocytosis
negative regulation of eosinophil degranulation (GO:0043310)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of eosinophil degranulation.
Synonyms: down regulation of eosinophil degranulation; down-regulation of eosinophil degranulation; downregulation of eosinophil degranulation; inhibition of eosinophil degranulation; negative regulation of eosinophil granule exocytosis
positive regulation of eosinophil degranulation (GO:0043311)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.
Synonyms: activation of eosinophil degranulation; positive regulation of eosinophil granule exocytosis; stimulation of eosinophil degranulation; up regulation of eosinophil degranulation; up-regulation of eosinophil degranulation; upregulation of eosinophil degranulation
neutrophil degranulation (GO:0043312)
Namespace: biological_process
Definition: The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
Synonyms: heterophil degranulation; neutrophil granule exocytosis
regulation of neutrophil degranulation (GO:0043313)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of neutrophil degranulation.
Synonyms: regulation of neutrophil granule exocytosis
negative regulation of neutrophil degranulation (GO:0043314)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of neutrophil degranulation.
Synonyms: down regulation of neutrophil degranulation; down-regulation of neutrophil degranulation; downregulation of neutrophil degranulation; inhibition of neutrophil degranulation; negative regulation of neutrophil granule exocytosis
positive regulation of neutrophil degranulation (GO:0043315)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of neutrophil degranulation.
Synonyms: activation of neutrophil degranulation; positive regulation of neutrophil granule exocytosis; stimulation of neutrophil degranulation; up regulation of neutrophil degranulation; up-regulation of neutrophil degranulation; upregulation of neutrophil degranulation
cytotoxic T cell degranulation (GO:0043316)
Namespace: biological_process
Definition: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.
Synonyms: cytotoxic T cell granule exocytosis; cytotoxic T lymphocyte degranulation; cytotoxic T lymphocyte granule exocytosis; cytotoxic T-cell degranulation; cytotoxic T-cell granule exocytosis; cytotoxic T-lymphocyte degranulation; cytotoxic T-lymphocyte granule exocytosis
regulation of cytotoxic T cell degranulation (GO:0043317)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation.
Synonyms: regulation of cytotoxic T cell granule exocytosis; regulation of cytotoxic T lymphocyte degranulation; regulation of cytotoxic T lymphocyte granule exocytosis; regulation of cytotoxic T-cell degranulation; regulation of cytotoxic T-cell granule exocytosis; regulation of cytotoxic T-lymphocyte degranulation; regulation of cytotoxic T-lymphocyte granule exocytosis
negative regulation of cytotoxic T cell degranulation (GO:0043318)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.
Synonyms: down regulation of cytotoxic T cell degranulation; down-regulation of cytotoxic T cell degranulation; downregulation of cytotoxic T cell degranulation; inhibition of cytotoxic T cell degranulation; negative regulation of cytotoxic T cell granule exocytosis; negative regulation of cytotoxic T lymphocyte degranulation; negative regulation of cytotoxic T lymphocyte granule exocytosis; negative regulation of cytotoxic T-cell degranulation; negative regulation of cytotoxic T-cell granule exocytosis; negative regulation of cytotoxic T-lymphocyte degranulation; negative regulation of cytotoxic T-lymphocyte granule exocytosis
positive regulation of cytotoxic T cell degranulation (GO:0043319)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation.
Synonyms: activation of cytotoxic T cell degranulation; positive regulation of cytotoxic T cell granule exocytosis; positive regulation of cytotoxic T lymphocyte degranulation; positive regulation of cytotoxic T lymphocyte granule exocytosis; positive regulation of cytotoxic T-cell degranulation; positive regulation of cytotoxic T-cell granule exocytosis; positive regulation of cytotoxic T-lymphocyte degranulation; positive regulation of cytotoxic T-lymphocyte granule exocytosis; stimulation of cytotoxic T cell degranulation; up regulation of cytotoxic T cell degranulation; up-regulation of cytotoxic T cell degranulation; upregulation of cytotoxic T cell degranulation
natural killer cell degranulation (GO:0043320)
Namespace: biological_process
Definition: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.
Synonyms: natural killer cell granule exocytosis; NK cell degranulation; NK cell granule exocytosis
regulation of natural killer cell degranulation (GO:0043321)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of natural killer cell degranulation.
Synonyms: regulation of natural killer cell granule exocytosis; regulation of NK cell degranulation; regulation of NK cell granule exocytosis
negative regulation of natural killer cell degranulation (GO:0043322)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of natural killer cell degranulation.
Synonyms: down regulation of natural killer cell degranulation; down-regulation of natural killer cell degranulation; downregulation of natural killer cell degranulation; inhibition of natural killer cell degranulation; negative regulation of natural killer cell granule exocytosis; negative regulation of NK cell degranulation; negative regulation of NK cell granule exocytosis
positive regulation of natural killer cell degranulation (GO:0043323)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation.
Synonyms: activation of natural killer cell degranulation; positive regulation of natural killer cell granule exocytosis; positive regulation of NK cell degranulation; positive regulation of NK cell granule exocytosis; stimulation of natural killer cell degranulation; up regulation of natural killer cell degranulation; up-regulation of natural killer cell degranulation; upregulation of natural killer cell degranulation
pigment metabolic process involved in developmental pigmentation (GO:0043324)
Namespace: biological_process
Definition: The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism.
Synonyms: pigment metabolic process during developmental pigmentation; pigment metabolism during developmental pigmentation
phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)
Namespace: molecular_function
Definition: Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
chemotaxis to folate (GO:0043326)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism in response to the presence of folate.
chemotaxis to cAMP (GO:0043327)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
Synonyms: chemotaxis to 3',5' cAMP; chemotaxis to 3',5'-cAMP; chemotaxis to adenosine 3',5'-cyclophosphate; chemotaxis to cyclic AMP
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043328)
Namespace: biological_process
Definition: The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
Synonyms: protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway; protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway; protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway; protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway; protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway; protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway; protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway; protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway; protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway
obsolete protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043329)
Namespace: biological_process
Definition: OBSOLETE. The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway.
Synonyms: protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway; protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway; protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway; protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway; protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway; protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway; protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway; protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway; protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway
Comment: The reason for obsoleting is that the term is not clearly defined, ie the membrane to which proteins are being targeted is not specified.
response to exogenous dsRNA (GO:0043330)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
Synonyms: response to exogenous double-stranded RNA; response to viral dsRNA
Comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'.
response to dsRNA (GO:0043331)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.
Synonyms: response to double-stranded RNA
mating projection tip (GO:0043332)
Namespace: cellular_component
Definition: The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
Synonyms: conjugation tube tip; shmoo tip
obsolete 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity (GO:0043333)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
Synonyms: 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
Comment: This term was obsoleted because it represents a specific substrate.
obsolete 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (GO:0043334)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
Synonyms: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity
Comment: This term was obsoleted because it represents a specific substrate.
protein unfolding (GO:0043335)
Namespace: biological_process
Definition: The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
site-specific telomere resolvase activity (GO:0043336)
Namespace: molecular_function
Definition: Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases.
Synonyms: ResT; TelN
Comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres.
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase activity (GO:0043338)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H+ = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate.
Synonyms: CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase; CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity
enucleate erythrocyte differentiation (GO:0043353)
Namespace: biological_process
Definition: The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.
Synonyms: enucleate RBC differentiation; enucleate red blood cell differentiation
enucleate erythrocyte maturation (GO:0043354)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus.
Synonyms: enucleate RBC maturation; enucleate red blood cell maturation
nucleate erythrocyte maturation (GO:0043362)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.
Synonyms: nucleate RBC maturation; nucleate red blood cell maturation
nucleate erythrocyte differentiation (GO:0043363)
Namespace: biological_process
Definition: The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.
Synonyms: nucleate RBC differentiation; nucleate red blood cell differentiation
glycyl-radical enzyme activating activity (GO:0043364)
Namespace: molecular_function
Definition: Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM).
Synonyms: catalysis of free radical formation
[formate-C-acetyltransferase]-activating enzyme activity (GO:0043365)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical.
Synonyms: [pyruvate formate-lyase]-activating enzyme activity; formate acetyltransferase activating enzyme activity; formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity; formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving); formate-C-acetyltransferase-activating enzyme; PFL activase activity; PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity; pyruvate formate-lyase-activating enzyme
beta selection (GO:0043366)
Namespace: biological_process
Definition: The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.
CD4-positive, alpha-beta T cell differentiation (GO:0043367)
Namespace: biological_process
Definition: The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
Synonyms: CD4-positive, alpha beta T cell development; CD4-positive, alpha beta T cell differentiation; CD4-positive, alpha-beta T lymphocyte differentiation; CD4-positive, alpha-beta T-cell differentiation; CD4-positive, alpha-beta T-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
positive T cell selection (GO:0043368)
Namespace: biological_process
Definition: The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms: positive T lymphocyte selection; positive T-cell selection; positive T-lymphocyte selection
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)
Namespace: biological_process
Definition: The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.
Synonyms: CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment; CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment; CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment; CD4-positive/CD8-positive, alpha-beta T cell lineage commitment
regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
Synonyms: regulation of CD4-positive T lymphocyte differentiation; regulation of CD4-positive T-cell differentiation; regulation of CD4-positive T-lymphocyte differentiation; regulation of CD4-positive, alpha beta T cell development; regulation of CD4-positive, alpha beta T cell differentiation; regulation of CD4-positive, alpha beta T lymphocyte differentiation; regulation of CD4-positive, alpha beta T-cell differentiation; regulation of CD4-positive, alpha beta T-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
Synonyms: down regulation of CD4-positive, alpha beta T cell differentiation; down-regulation of CD4-positive, alpha beta T cell differentiation; downregulation of CD4-positive, alpha beta T cell differentiation; inhibition of CD4-positive, alpha beta T cell differentiation; negative regulation of CD4-positive T-cell differentiation; negative regulation of CD4-positive T-lymphocyte differentiation; negative regulation of CD4-positive, alpha beta T cell development; negative regulation of CD4-positive, alpha beta T lymphocyte differentiation; negative regulation of CD4-positive, alpha beta T-cell differentiation; negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.