LiteFold/GO huggingface dataset:
alpha5-beta1 integrin-fibronectin-NOV complex (GO:0071117)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV.
Synonyms: ITGA5-ITGB1-FN-1-NOV complex
alphaV-beta3 integrin-NOV complex (GO:0071118)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV.
Synonyms: ITGAV-ITGB3-FN-1-NOV complex
alpha7-beta1 integrin-nicotinamide riboside kinase complex (GO:0071119)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP).
Synonyms: ITGA7-ITGB1-ITGB1BP3 complex
alpha4-beta1 integrin-CD47 complex (GO:0071120)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47.
Synonyms: ITGA4-ITGB1-CB47 complex
alpha9-beta1 integrin-VEGF-D complex (GO:0071121)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D.
Synonyms: ITGA9-ITGB1-FIGF complex
alpha9-beta1 integrin-VEGF-A complex (GO:0071122)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A.
Synonyms: ITGA9-ITGB1-VEGFA complex
alpha9-beta1 integrin-VEGF-C complex (GO:0071123)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C.
Synonyms: ITGA9-ITGB1-VEGFC complex
alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex (GO:0071124)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2.
Synonyms: ITGA1-ITGB1-PTPN2 complex
alphaV-beta3 integrin-EGFR complex (GO:0071125)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor.
Synonyms: ITGAV-ITGB3-EGFR complex
alphaV-beta6 integrin-osteopontin complex (GO:0071126)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin.
Synonyms: ITGAV-ITGB6-SPP1 complex
alphaV-beta3 integrin-LPP3 complex (GO:0071129)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3.
Synonyms: ITGAV-ITGB3-PPAP2B complex
alpha5-beta1 integrin-LPP3 complex (GO:0071130)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3.
Synonyms: ITGA5-ITGB1-PPAP2B complex
alphaV-beta3 integrin-laminin alpha-4 complex (GO:0071131)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4.
Synonyms: ITGAV-ITGB3-LAMA4 complex
alphaX-beta2 integrin-ICAM-4 complex (GO:0071132)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4.
Synonyms: ITGAX-ITGB2-ICAM4 complex
alpha7-beta1 integrin-laminin alpha-2 complex (GO:0071136)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2.
Synonyms: ITGA7-ITGB1-LAMA2 complex
alphaV-beta3 integrin-CD98 complex (GO:0071137)
Namespace: cellular_component
Definition: A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98.
Synonyms: ITGAV-ITGB3-SLC3A2 complex
alpha5-beta5-fibronectin-SFRP2 complex (GO:0071138)
Namespace: cellular_component
Definition: A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2.
Synonyms: ITGA5-ITGB5-FN-1-SFRP2 complex
resolution of DNA recombination intermediates (GO:0071139)
Namespace: biological_process
Definition: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged.
Synonyms: resolution of recombination intermediates
resolution of mitotic recombination intermediates (GO:0071140)
Namespace: biological_process
Definition: The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged.
SMAD protein complex (GO:0071141)
Namespace: cellular_component
Definition: A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven.
Synonyms: SMAD complex
heteromeric SMAD protein complex (GO:0071144)
Namespace: cellular_component
Definition: A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
Synonyms: SMAD1-SMAD4 protein complex; SMAD2-SMAD3-SMAD4 protein complex; SMAD2-SMAD4 protein complex; SMAD3-SMAD4 protein complex
G-protein alpha(q)-synembrin complex (GO:0071152)
Namespace: cellular_component
Definition: A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein.
Synonyms: Ric-8A G(q) alpha subunit complex
G-protein alpha(o)-synembrin complex (GO:0071153)
Namespace: cellular_component
Definition: A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein.
Synonyms: Ric-8A G(o) alpha-1 subunit complex; Ric-8A G(o) alpha-2 subunit complex
G-protein alpha(i)1-synembrin complex (GO:0071154)
Namespace: cellular_component
Definition: A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein.
Synonyms: Ric-8A G(i) alpha-1 subunit complex; Ric-8A G(i) alpha-2 subunit complex
G-protein alpha(13)-synembrin complex (GO:0071155)
Namespace: cellular_component
Definition: A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein.
Synonyms: Ric-8A G alpha 13 subunit complex
NF-kappaB complex (GO:0071159)
Namespace: cellular_component
Definition: A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.
cyanophycin synthetase activity (L-aspartate-adding) (GO:0071160)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp.
cyanophycin synthetase activity (L-arginine-adding) (GO:0071161)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1.
CMG complex (GO:0071162)
Namespace: cellular_component
Definition: A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
Synonyms: unwindosome
DNA replication preinitiation complex assembly (GO:0071163)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity.
Synonyms: DNA replication preinitiation complex formation; pre-IC complex assembly
RNA cap trimethylguanosine synthase activity (GO:0071164)
Namespace: molecular_function
Definition: Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine.
Synonyms: cap hypermethylase activity; RNA trimethylguanosine synthase activity; small nuclear RNA methyltransferase activity; snRNA methyltransferase activity
Comment: A 2,2,7-trimethylguanosine (TMG) cap is found on many RNA polymerase II transcribed small noncoding RNAs including small nuclear RNA (snRNA), small nucleolar RNA (snoRNA) and telomerase RNA. It is also found on nematode mRNAs that undergo trans-splicing of a 5'-capped leader sequence.
GINS complex assembly (GO:0071165)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks.
ribonucleoprotein complex localization (GO:0071166)
Namespace: biological_process
Definition: Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell.
Synonyms: cellular ribonucleoprotein complex localization; establishment and maintenance of ribonucleoprotein complex localization; ribonucleoprotein complex localisation; RNP localization
obsolete ribonucleoprotein complex import into nucleus (GO:0071167)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus.
Synonyms: ribonucleoprotein complex import into cell nucleus; ribonucleoprotein complex nucleus import; ribonucleoprotein complex targeting to nucleus; ribonucleoprotein complex transport from cytoplasm to nucleus; ribonucleoprotein import into nucleus; RNP import into nucleus
Comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
protein localization to chromatin (GO:0071168)
Namespace: biological_process
Definition: Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
Synonyms: protein localisation to chromatin
establishment of protein localization to chromatin (GO:0071169)
Namespace: biological_process
Definition: The directed movement of a protein to a part of a chromosome that is organized into chromatin.
Synonyms: establishment of protein localisation to chromatin
site-specific DNA replication termination (GO:0071170)
Namespace: biological_process
Definition: A DNA replication termination process that takes place at a specific termination site.
Comment: See also the biological process term 'replication fork arrest ; GO:0043111' and its children.
site-specific DNA replication termination at RTS1 barrier (GO:0071171)
Namespace: biological_process
Definition: A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching.
dihydromonapterin reductase activity (GO:0071172)
Namespace: molecular_function
Definition: Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+.
spindle assembly checkpoint signaling (GO:0071173)
Namespace: biological_process
Definition: A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.
Synonyms: SAC; signal transduction involved in spindle assembly checkpoint; spindle assembly checkpoint
Comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic).
mitotic spindle checkpoint signaling (GO:0071174)
Namespace: biological_process
Definition: A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.
Synonyms: mitotic cell cycle spindle checkpoint; mitotic spindle checkpoint; signal transduction involved in mitotic cell cycle spindle checkpoint; signal transduction involved in mitotic spindle checkpoint; topo II checkpoint; topoisomerase II checkpoint
Comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints).
MAML2-RBP-Jkappa-ICN1 complex (GO:0071175)
Namespace: cellular_component
Definition: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms: MAML2-RBP-Jkappa-Notch1 complex
MAML2-RBP-Jkappa-ICN2 complex (GO:0071176)
Namespace: cellular_component
Definition: A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms: MAML2-RBP-Jkappa-Notch2 complex
MAML2-RBP-Jkappa-ICN3 complex (GO:0071177)
Namespace: cellular_component
Definition: A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms: MAML2-RBP-Jkappa-Notch3 complex
MAML2-RBP-Jkappa-ICN4 complex (GO:0071178)
Namespace: cellular_component
Definition: A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms: MAML2-RBP-Jkappa-Notch4 complex
MAML3-RBP-Jkappa-ICN1 complex (GO:0071179)
Namespace: cellular_component
Definition: A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms: MAML3-RBP-Jkappa-Notch1 complex
MAML3-RBP-Jkappa-ICN3 complex (GO:0071181)
Namespace: cellular_component
Definition: A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
Synonyms: MAML3-RBP-Jkappa-Notch3 complex
protocadherin-alpha-protocadherin-gamma complex (GO:0071183)
Namespace: cellular_component
Definition: A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane.
protocadherin-alpha-v4-protocadherin-gamma-a1 complex (GO:0071184)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdhga1-Pcdha4 complex
protocadherin-alpha-v4-protocadherin-gamma-a3 complex (GO:0071185)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdhga1-Pcdhga3 complex
protocadherin-alpha-v4-protocadherin-gamma-b2 complex (GO:0071186)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdhga1-Pcdhgb2 complex
protocadherin-alpha-v4-protocadherin-gamma-b4 complex (GO:0071187)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdhga1-Pcdhgb4 complex
protocadherin-alpha-v7-protocadherin-gamma-a1 complex (GO:0071188)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdha7-Pcdhga1 complex
protocadherin-alpha-v7-protocadherin-gamma-a3 complex (GO:0071189)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdha7-Pcdhga3 complex
protocadherin-alpha-v7-protocadherin-gamma-b2 complex (GO:0071190)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdha7-Pcdhgb4 complex
protocadherin-alpha-v7-protocadherin-gamma-b4 complex (GO:0071191)
Namespace: cellular_component
Definition: A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
Synonyms: Pcdha7-Pcdhgb2 complex
Kv4.2-KChIP1 channel complex (GO:0071192)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.2-KChIP2 channel complex (GO:0071193)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.2-KChIP3 channel complex (GO:0071194)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.2-KChIP4 channel complex (GO:0071195)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.3-KChIP1 channel complex (GO:0071196)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3.
Kv4.2-Kv4.3 channel complex (GO:0071197)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3.
Kv4.1-DPP6 channel complex (GO:0071198)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1.
Synonyms: Kv4.1-DPPX channel complex
Kv4.1-DPP10 channel complex (GO:0071199)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1.
Synonyms: Kv4.1-DPPY channel complex
Kv4.2-DPP6 channel complex (GO:0071200)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2.
Synonyms: Kv4.2-DPPX channel complex
Kv4.3-DPP6 channel complex (GO:0071201)
Namespace: cellular_component
Definition: A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3.
Synonyms: Kv4.3-DPPX channel complex
WASH complex (GO:0071203)
Namespace: cellular_component
Definition: A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.
histone pre-mRNA 3'end processing complex (GO:0071204)
Namespace: cellular_component
Definition: A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1.
Synonyms: histone 3'end pre-mRNA complex
protein localization to juxtaparanode region of axon (GO:0071205)
Namespace: biological_process
Definition: Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon.
Synonyms: protein localisation to juxtaparanode region of axon
establishment of protein localization to juxtaparanode region of axon (GO:0071206)
Namespace: biological_process
Definition: The directed movement of a protein to the juxtaparanode region of an axon.
Synonyms: establishment of protein localisation to juxtaparanode region of axon
histone pre-mRNA stem-loop binding (GO:0071207)
Namespace: molecular_function
Definition: Binding to a conserved stem-loop structure found in histone pre-mRNAs.
U7 snRNA binding (GO:0071209)
Namespace: molecular_function
Definition: Binding to a U7 small nuclear RNA (U7 snRNA).
Comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs).
protein insertion into membrane raft (GO:0071210)
Namespace: biological_process
Definition: The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.
Synonyms: establishment of protein localization to membrane raft
protein targeting to vacuole involved in autophagy (GO:0071211)
Namespace: biological_process
Definition: The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm.
Synonyms: protein targeting to autophagosome
subsynaptic reticulum (GO:0071212)
Namespace: cellular_component
Definition: An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
Synonyms: SSR