LiteFold/GO huggingface dataset:
histone H3K23 ubiquitin ligase activity (GO:0140234)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-23 residue.
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
RNA polyadenylation at postsynapse (GO:0140235)
Namespace: biological_process
Definition: A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
translation at presynapse (GO:0140236)
Namespace: biological_process
Definition: Translation that occurs at the presynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
translation at presynapse, modulating chemical synaptic transmission (GO:0140237)
Namespace: biological_process
Definition: Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
presynaptic endocytosis (GO:0140238)
Namespace: biological_process
Definition: A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
postsynaptic endocytosis (GO:0140239)
Namespace: biological_process
Definition: A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
perforant pathway to dendrate granule cell synapse (GO:0140240)
Namespace: cellular_component
Definition: A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.
Synonyms: perforant pathway to DG granule cell synapse
translation at synapse (GO:0140241)
Namespace: biological_process
Definition: Translation that occurs at the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
translation at postsynapse (GO:0140242)
Namespace: biological_process
Definition: Translation that occurs at the postsynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at synapse (GO:0140243)
Namespace: biological_process
Definition: Any process that regulates translation occurring at the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at presynapse (GO:0140244)
Namespace: biological_process
Definition: Any process that regulates translation occurring at the presynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
protein catabolic process at synapse (GO:0140246)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
protein catabolic process at presynapse (GO:0140247)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
histone H3K18 ubiquitin ligase activity (GO:0140248)
Namespace: molecular_function
Definition: Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-18 residue.
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
regulation protein catabolic process at presynapse (GO:0140251)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation protein catabolic process at postsynapse (GO:0140252)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
histone H3K18ub reader activity (GO:0140254)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 ubiquitinated at lysine 18.
Synonyms: H3K18ub modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
regulation of cellular response to phosphate starvation (GO:0140255)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation.
negative regulation of cellular response to phosphate starvation (GO:0140256)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation.
histone H3K23ub reader activity (GO:0140257)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 ubiquitinated at lysine 23.
Synonyms: H3K23ub modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K14ub reader activity (GO:0140258)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 ubiquitinated at lysine 14.
Synonyms: H3-K14ub reader activity; H3K14ub modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
PRC1 complex binding (GO:0140259)
Namespace: molecular_function
Definition: Binding to a PRC1 complex.
mitochondrial proton-transporting ATP synthase complex binding (GO:0140260)
Namespace: molecular_function
Definition: Binding to a mitochondrial proton-transporting ATP synthase complex.
BCOR complex (GO:0140261)
Namespace: cellular_component
Definition: A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10.
Synonyms: BCL6 corepressor (BCOR) complex; BCOR/BCORL1 complex; non-canonical BCOR-PRC1.1 complex; non-canonical PRC1-BCOR complex; PRC1.1 complex
mRNA cap binding complex binding (GO:0140262)
Namespace: molecular_function
Definition: Binding to a mRNA cap binding complex.
keratan sulfate-I proteoglycan biosynthetic process (GO:0140263)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of keratan sulfate I (KS-I), N-linked via a GlcNAc attached to an asparigine residue in the target protein.
Synonyms: N-linked GlcNac-keratan sulfate-I proteoglycan biosynthetic process
keratan sulfate-II proteoglycan biosynthetic process (GO:0140264)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of keratan sulfate II (KS-II), O-linked via a GalNAc attached to a serine or a threonine residue in the target protein.
Synonyms: O-linked GalNAc-keratan sulfate-II proteoglycan biosynthetic process
keratan sulfate-III proteoglycan biosynthetic process (GO:0140265)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of keratan sulfate III (KS-III), O-linked via a mannose attached to a serine or a threonine residue in the target protein.
Synonyms: O-linked man-keratan sulfate-III proteoglycan biosynthetic process
Woronin body (GO:0140266)
Namespace: cellular_component
Definition: Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes.
endoplasmic reticulum-plasma membrane contact site (GO:0140268)
Namespace: cellular_component
Definition: A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.
Synonyms: endoplasmic reticulum-plasma membrane contact junction; EPCS; ER-plasma membrane contact site; ER-PM contact site
arthro-series glucosylceramide biosynthetic process (GO:0140269)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of arthro-series glucosylceramides that begins with the synthesis of a tetrasaccharide core GalNAc-beta-1,4-GlcNAc-beta-1,3-Man-beta-1,4Glc-ceramide. This core can be further elongated with the sequential addition of various carbohydrate units.
gluconate import across plasma membrane (GO:0140270)
Namespace: biological_process
Definition: The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol.
exogenous protein binding (GO:0140272)
Namespace: molecular_function
Definition: Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein.
Comment: Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant.
repair of mitotic kinetochore microtubule attachment defect (GO:0140273)
Namespace: biological_process
Definition: The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected.
Synonyms: correction of mitotic kinetochore microtubule attachment defects; repair of mitotic kinetochore microtubule attachment defects
repair of kinetochore microtubule attachment defect (GO:0140274)
Namespace: biological_process
Definition: The cell cycle process where kinetochore microtubule attachment defects are corrected.
Synonyms: correction of kinetochore microtubule attachment defects; repair of kinetochore microtubule attachment defects
MIB complex (GO:0140275)
Namespace: cellular_component
Definition: A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1.
Synonyms: mitochondrial intermembrane space bridging complex; mitofilin complex
endoplasmic reticulum N-glycan trimming (GO:0140277)
Namespace: biological_process
Definition: The trimming, in the ER, of the protein newly attached N-glycan by glucosidases and mannosidases to produce high mannose-type N-glycans.
Synonyms: ER N-glycan trimming
negative regulation of mitotic division septum assembly (GO:0140280)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
Synonyms: down regulation of division septum formation involved in mitotic cell cycle; down regulation of formation of division septum involved in mitotic cell cycle; down regulation of mitotic division septum assembly; down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; down regulation of septin assembly and septum formation involved in mitotic cell cycle; down-regulation of division septum formation involved in mitotic cell cycle; down-regulation of formation of division septum involved in mitotic cell cycle; down-regulation of mitotic division septum assembly; down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; down-regulation of septin assembly and septum formation involved in mitotic cell cycle; downregulation of division septum formation involved in mitotic cell cycle; downregulation of formation of division septum involved in mitotic cell cycle; downregulation of mitotic division septum assembly; downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; downregulation of septin assembly and septum formation involved in mitotic cell cycle; inhibition of division septum formation involved in mitotic cell cycle; inhibition of formation of division septum involved in mitotic cell cycle; inhibition of mitotic division septum assembly; inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle; inhibition of septin assembly and septum formation involved in mitotic cell cycle; negative regulation of division septum formation involved in mitotic cell cycle; negative regulation of formation of division septum involved in mitotic cell cycle; negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; negative regulation of septin assembly and septum formation involved in mitotic cell cycle
positive regulation of mitotic division septum assembly (GO:0140281)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
Synonyms: activation of division septum formation involved in mitotic cell cycle; activation of formation of division septum involved in mitotic cell cycle; activation of mitotic division septum assembly; activation of septin assembly and septum biosynthesis involved in mitotic cell cycle; activation of septin assembly and septum formation involved in mitotic cell cycle; positive regulation of division septum formation involved in mitotic cell cycle; positive regulation of formation of division septum involved in mitotic cell cycle; positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; positive regulation of septin assembly and septum formation involved in mitotic cell cycle; up regulation of division septum formation involved in mitotic cell cycle; up regulation of formation of division septum involved in mitotic cell cycle; up regulation of mitotic division septum assembly; up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; up regulation of septin assembly and septum formation involved in mitotic cell cycle; up-regulation of division septum formation involved in mitotic cell cycle; up-regulation of formation of division septum involved in mitotic cell cycle; up-regulation of mitotic division septum assembly; up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; up-regulation of septin assembly and septum formation involved in mitotic cell cycle; upregulation of division septum formation involved in mitotic cell cycle; upregulation of formation of division septum involved in mitotic cell cycle; upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; upregulation of septin assembly and septum formation involved in mitotic cell cycle
carbon-nitrogen ligase activity on lipid II (GO:0140282)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate.
Synonyms: L-glutamate--lipid II transaminase activity; undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity
HUSH complex (GO:0140283)
Namespace: cellular_component
Definition: A protein complex that mediates transcriptional silencing of mobile genetic elements, such as retroviruses and transposable elements. In human, it is composed of TASOR, PPHLN1 and MPHOSPH8.
endoplasmic reticulum-endosome membrane contact site (GO:0140284)
Namespace: cellular_component
Definition: A contact site between the endoplasmic reticulum membrane and the endosome membrane.
Synonyms: ER-endosome membrane contact site
endosome fission (GO:0140285)
Namespace: biological_process
Definition: The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.
HUSH2 complex (GO:0140286)
Namespace: cellular_component
Definition: A protein complex that mediates transcriptional silencing of interferon-stimulated genes. In human, it is composed of TASOR2, PPHLN1 and MPHOSPH8.
hydrazine dehydrogenase activity (GO:0140287)
Namespace: molecular_function
Definition: Catalysis of the reaction: hydrazine + 4 Fe(III)-[cytochrome c] = N2 + 4 Fe(II)-[cytochrome c] + 4 H+.
GBAF complex (GO:0140288)
Namespace: cellular_component
Definition: A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM.
obsolete protein mono-ADP-ribosylation (GO:0140289)
Namespace: biological_process
Definition: OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.
Comment: This term was obsoleted because it represents a molecular function.
peptidyl-serine ADP-deribosylation (GO:0140290)
Namespace: biological_process
Definition: The removal of ADP-ribose from ADP-ribosylserine.
peptidyl-glutamate ADP-deribosylation (GO:0140291)
Namespace: biological_process
Definition: The removal of ADP-ribose from ADP-ribosylglutamate.
ADP-ribosylserine hydrolase activity (GO:0140292)
Namespace: molecular_function
Definition: Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose.
NAD DNA ADP-ribosyltransferase activity (GO:0140294)
Namespace: molecular_function
Definition: Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA.
pathogen-derived receptor ligand activity (GO:0140295)
Namespace: molecular_function
Definition: The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.
Synonyms: host-selective toxin; innate receptor ligand activity; necrotrophic effector
Comment: Note that this term is meant to annotate effectors for which the evolved activity is to act as a ligand to activate (for necrotrophs) or suppress (for biotrophs) the host immune system. It should not be used to annotate PAMPs (pathogen-associated molecular pattern molecules) or similar types of microbial proteins recognized by the host innate immune system (for example, PAMPs are recognized by toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals). PAMPs activate innate immune responses, protecting the host from infection, but this is not the molecular function of PAMPs; those usually form the structure of the bacterial cell wall.
general transcription initiation factor binding (GO:0140296)
Namespace: molecular_function
Definition: Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.
DNA-binding transcription factor binding (GO:0140297)
Namespace: molecular_function
Definition: Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
Synonyms: activating transcription factor binding; repressing transcription factor binding; transcription activator binding
endocytic iron import into cell (GO:0140298)
Namespace: biological_process
Definition: Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis.
Synonyms: iron import into cell by endocytosis
molecular sensor activity (GO:0140299)
Namespace: molecular_function
Definition: Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
Synonyms: small molecular sensor activity; small molecule sensing activity; small molecule sensor activity
serine import into mitochondrion (GO:0140300)
Namespace: biological_process
Definition: The process in which serine is transported from the cytosol into the mitochondrial matrix.
pollen-stigma interaction (GO:0140301)
Namespace: biological_process
Definition: The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae.
pollen-style interaction (GO:0140302)
Namespace: biological_process
Definition: The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte.
intramembrane lipid carrier activity (GO:0140303)
Namespace: molecular_function
Definition: Enables the transport of a lipid from a region of a membrane to a different region on the same membrane.
Synonyms: flippase activity; intramembrane lipid transporter activity; translocase activity
hydrazine synthase activity (GO:0140304)
Namespace: molecular_function
Definition: Catalysis of the reaction: hydrazine + 3 Fe(III)-[cytochrome c] + H2O = nitric oxide + 3 Fe(II)-[cytochrome c] + NH4+ + 2 H+.
hydroxylamine dehydrogenase activity (GO:0140305)
Namespace: molecular_function
Definition: Catalysis of the reaction: hydroxylamine + 4 Fe(III)-[cytochrome c] + H2O = 4 Fe(II)-[cytochrome c] + nitrite + 5 H+.