LiteFold/GO huggingface dataset:
box H/ACA sno(s)RNA processing (GO:0034964)
Namespace: biological_process
Definition: Any process involved in the conversion of a primary box H/ACA type small RNA transcript into a mature box H/ACA RNA.
Synonyms: box H/ACA snoRNA processing; box H/ACA sRNA processing
intronic box C/D snoRNA processing (GO:0034965)
Namespace: biological_process
Definition: Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA.
intronic box H/ACA snoRNA processing (GO:0034966)
Namespace: biological_process
Definition: Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA.
Set3 complex (GO:0034967)
Namespace: cellular_component
Definition: A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.
Synonyms: HDAC3 complex; SET3C
obsolete histone lysine methylation (GO:0034968)
Namespace: biological_process
Definition: OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone arginine methylation (GO:0034969)
Namespace: biological_process
Definition: OBSOLETE. The modification of a histone by addition of a methyl group to an arginine residue.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-R2 methylation (GO:0034970)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone.
Synonyms: histone H3 R2 methylation; histone H3R2me; histone lysine H3 R2 methylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-R17 methylation (GO:0034971)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone.
Synonyms: histone H3 R17 methylation; histone H3R17me; histone lysine H3 R17 methylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-R26 methylation (GO:0034972)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone.
Synonyms: histone H3 R26 methylation; histone H3R26me; histone lysine H3 R26 methylation
Comment: This term was obsoleted because it represents a molecular function.
Sid2-Mob1 complex (GO:0034973)
Namespace: cellular_component
Definition: A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex.
Synonyms: Dbf2p-Mob1p complex; Sid2-Mob1 kinase complex; Sid2p-Mob1p complex
Swi5-Swi2 complex (GO:0034974)
Namespace: cellular_component
Definition: A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching.
Synonyms: Swi5 complex
Comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p.
protein folding in endoplasmic reticulum (GO:0034975)
Namespace: biological_process
Definition: A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).
Synonyms: oxidative protein folding; protein folding in ER
ABIN2-NFKB1-MAP3K8 complex (GO:0034977)
Namespace: cellular_component
Definition: A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages.
Synonyms: ABIN2-NFKB1-TPL-1 complex
PDX1-PBX1b-MRG1 complex (GO:0034978)
Namespace: cellular_component
Definition: A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.
Synonyms: acinar cell-specific C complex
NAD-dependent protein lysine deacetylase activity (GO:0034979)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide.
Synonyms: NAD(+)-dependent protein deacetylase; NAD(+)-dependent protein deacylase; NAD-dependent protein deacetylase activity; protein acetyllysine N-acetyltransferase; protein lysine deacetylase; protein lysine deacylase
FHL2-CREB complex (GO:0034980)
Namespace: cellular_component
Definition: A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation.
FHL3-CREB complex (GO:0034981)
Namespace: cellular_component
Definition: A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation.
mitochondrial protein processing (GO:0034982)
Namespace: biological_process
Definition: The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
Synonyms: mitochondrial protein modification
peptidyl-lysine deacetylation (GO:0034983)
Namespace: biological_process
Definition: The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.
Synonyms: protein lysine acetylation
iron chaperone activity (GO:0034986)
Namespace: molecular_function
Definition: Directly binding to and delivering iron ions to a target protein.
Synonyms: iron carrier activity
immunoglobulin receptor binding (GO:0034987)
Namespace: molecular_function
Definition: Binding to one or more specific sites on an immunoglobulin receptor molecule.
Synonyms: Fc receptor binding
Fc-gamma receptor I complex binding (GO:0034988)
Namespace: molecular_function
Definition: Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
microtubule organizing center attachment site (GO:0034992)
Namespace: cellular_component
Definition: A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope.
Synonyms: MAS; microtubule organising centre attachment site; MTOC attachment site
Comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
meiotic nuclear membrane microtubule tethering complex (GO:0034993)
Namespace: cellular_component
Definition: A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.
Synonyms: LINC complex; LInker of Nucleoskeleton and Cytoskeleton complex; SUN-KASH complex
microtubule organizing center attachment site organization (GO:0034994)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches.
Synonyms: MAS organization; microtubule organising centre attachment site organisation; MTOC attachment site organization
SC5b-7 complex (GO:0034995)
Namespace: cellular_component
Definition: A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly.
RasGAP-Fyn-Lyn-Yes complex (GO:0034996)
Namespace: cellular_component
Definition: A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.
Synonyms: p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
alphav-beta5 integrin-vitronectin complex (GO:0034997)
Namespace: cellular_component
Definition: A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin.
Synonyms: ITGAV-ITGB5-VTN complex
obsolete oligosaccharyltransferase I complex (GO:0034998)
Namespace: cellular_component
Definition: OBSOLETE. An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes.
Synonyms: OSTCI
Comment: The reason for obsoletion is that the meaning of the term is ambiguous and the data from the paper for which the term was requested can be accurately described using GO:0008250 oligosaccharyltransferase complex.
obsolete oligosaccharyltransferase II complex (GO:0034999)
Namespace: cellular_component
Definition: OBSOLETE. An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes.
Synonyms: OSTCII
Comment: The reason for obsoletion is that the meaning of the term is ambiguous and the data from the paper for which the term was requested can be accurately described using GO:0008250 oligosaccharyltransferase complex.
dorsal trunk growth, open tracheal system (GO:0035001)
Namespace: biological_process
Definition: Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system.
Synonyms: dorsal trunk growth
liquid clearance, open tracheal system (GO:0035002)
Namespace: biological_process
Definition: The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system.
Synonyms: tracheal liquid clearance
subapical complex (GO:0035003)
Namespace: cellular_component
Definition: The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
Synonyms: SAC
obsolete phosphatidylinositol 3-kinase activity (GO:0035004)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.
Synonyms: phosphoinositide 3-kinase activity
Comment: This term was obsoleted because it is an unnecessary grouping class.
1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + H+.
Synonyms: ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity; C2-domain-containing phosphoinositide 3-kinase activity; phosphatidylinositol 3-kinase activity, class I; phosphatidylinositol 3-kinase activity, class II; phosphatidylinositol 3-kinase, class I, catalyst activity; phosphatidylinositol-4-phosphate 3-kinase activity; type II phosphoinositide 3-kinase activity
melanization defense response (GO:0035006)
Namespace: biological_process
Definition: The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin.
Synonyms: melanization defence response
regulation of melanization defense response (GO:0035007)
Namespace: biological_process
Definition: Any process that affects the rate, extent or location of the melanization defense response during injury or invasion.
Synonyms: regulation of melanization defence response
positive regulation of melanization defense response (GO:0035008)
Namespace: biological_process
Definition: Any process that increases the rate or extent of the melanization defense response during injury or invasion.
Synonyms: activation of melanization defense response; positive regulation of melanization defence response; stimulation of melanization defense response; up regulation of melanization defense response; up-regulation of melanization defense response; upregulation of melanization defense response
negative regulation of melanization defense response (GO:0035009)
Namespace: biological_process
Definition: Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection.
Synonyms: down regulation of melanization defense response; down-regulation of melanization defense response; downregulation of melanization defense response; inhibition of melanization defense response; negative regulation of melanization defence response
encapsulation of foreign target (GO:0035010)
Namespace: biological_process
Definition: Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization.
melanotic encapsulation of foreign target (GO:0035011)
Namespace: biological_process
Definition: Formation of a multilayered, melanized sheath of cells around a foreign invader.
obsolete polytene chromosome, telomeric region (GO:0035012)
Namespace: cellular_component
Definition: OBSOLETE. The terminal region of a polytene chromosome.
Comment: This term was obsoleted because it likely represents an assay for GO:0099115 chromosome, subtelomeric region.
myosuppressin receptor activity (GO:0035013)
Namespace: molecular_function
Definition: Combining with the peptide myosuppressin to initiate a change in cell activity.
phosphatidylinositol 3-kinase regulator activity (GO:0035014)
Namespace: molecular_function
Definition: Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
Synonyms: phosphoinositide 3-kinase regulator activity; PI3K regulator activity
Comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
elongation of arista core (GO:0035015)
Namespace: biological_process
Definition: The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions.
elongation of arista lateral (GO:0035016)
Namespace: biological_process
Definition: The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions.
cuticle pattern formation (GO:0035017)
Namespace: biological_process
Definition: The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.
adult chitin-based cuticle pattern formation (GO:0035018)
Namespace: biological_process
Definition: The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster.
Synonyms: adult cuticle pattern formation
regulation of Rac protein signal transduction (GO:0035020)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of Rac protein signal transduction.
positive regulation of Rac protein signal transduction (GO:0035022)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.
Synonyms: activation of Rac protein signal transduction; stimulation of Rac protein signal transduction; up regulation of Rac protein signal transduction; up-regulation of Rac protein signal transduction; upregulation of Rac protein signal transduction
regulation of Rho protein signal transduction (GO:0035023)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
positive regulation of Rho protein signal transduction (GO:0035025)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
Synonyms: activation of Rho protein signal transduction; stimulation of Rho protein signal transduction; up regulation of Rho protein signal transduction; up-regulation of Rho protein signal transduction; upregulation of Rho protein signal transduction
leading edge cell differentiation (GO:0035026)
Namespace: biological_process
Definition: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet.
leading edge cell fate commitment (GO:0035027)
Namespace: biological_process
Definition: The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet.
leading edge cell fate determination (GO:0035028)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed.
dorsal closure, leading edge cell fate commitment (GO:0035029)
Namespace: biological_process
Definition: The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis.
phosphatidylinositol 3-kinase complex, class III (GO:0035032)
Namespace: cellular_component
Definition: A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).
Synonyms: class III PI3K complex; phosphoinositide 3-kinase complex, class III
histone deacetylase regulator activity (GO:0035033)
Namespace: molecular_function
Definition: Binds to and modulates the activity of histone deacetylase.
Comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'.
histone acetyltransferase regulator activity (GO:0035034)
Namespace: molecular_function
Definition: Binds to and modulates the activity of histone acetyltransferase.
Synonyms: histone acetylase regulator activity
Comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
histone acetyltransferase binding (GO:0035035)
Namespace: molecular_function
Definition: Binding to an histone acetyltransferase.
Synonyms: histone acetylase binding
sperm-egg recognition (GO:0035036)
Namespace: biological_process
Definition: The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.
sperm entry (GO:0035037)
Namespace: biological_process
Definition: An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur.
female pronucleus assembly (GO:0035038)
Namespace: biological_process
Definition: Assembly of the haploid nucleus of the unfertilized egg.
male pronucleus assembly (GO:0035039)
Namespace: biological_process
Definition: The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division.
Synonyms: male pronucleus formation
sperm nuclear envelope removal (GO:0035040)
Namespace: biological_process
Definition: Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus.
sperm DNA decondensation (GO:0035041)
Namespace: biological_process
Definition: Unwinding of the condensed nuclear chromatin of an inactive male pronucleus after fertilization.
Synonyms: sperm chromatin decondensation
obsolete fertilization, exchange of chromosomal proteins (GO:0035042)
Namespace: biological_process
Definition: OBSOLETE. Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity.
Synonyms: sperm-specific histone exchange; sperm-specific histone replacement
Comment: This term has been obsoleted because it represents a molecular function (histone chaperone activity) and a process (sperm DNA decondensation).
male pronuclear envelope synthesis (GO:0035043)
Namespace: biological_process
Definition: Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation.
sperm aster formation (GO:0035044)
Namespace: biological_process
Definition: Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei.
sperm plasma membrane disassembly (GO:0035045)
Namespace: biological_process
Definition: The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg.
Synonyms: sperm plasma membrane breakdown; sperm plasma membrane catabolism; sperm plasma membrane degradation
pronuclear migration (GO:0035046)
Namespace: biological_process
Definition: The directed movement of the male and female pronuclei towards each other prior to their fusion.
centrosomal and pronuclear rotation (GO:0035047)
Namespace: biological_process
Definition: The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion.
obsolete splicing factor protein import into nucleus (GO:0035048)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane.
Synonyms: splicing factor protein transport from cytoplasm to nucleus; splicing factor protein-nucleus import
Comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.