LiteFold/GO huggingface dataset:
long-chain fatty acid-CoA ligase activity (GO:0004467)
Namespace: molecular_function
Definition: Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Synonyms: acyl-activating enzyme activity; acyl-CoA ligase activity; acyl-CoA synthetase activity; fatty acid thiokinase (long-chain) activity; LCFA synthetase activity; lignoceroyl-CoA synthase activity; long chain fatty acyl-CoA synthetase activity; long-chain acyl CoA synthetase activity; long-chain acyl-CoA synthetase activity; long-chain acyl-coenzyme A synthetase activity; long-chain fatty acid activation; long-chain fatty acyl coenzyme A synthetase activity; long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acyl-CoA synthetase activity; pristanoyl-CoA synthetase; stearoyl-CoA synthetase; thiokinase
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
L-lysine N6-acetyltransferase activity, acting on acetyl phosphate as donor (GO:0004468)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
Synonyms: acetyl-phosphate:L-lysine 6-N-acetyltransferase activity; acetyl-phosphate:L-lysine N6-acetyltransferase activity; LAT activity; lysine acetyltransferase activity; lysine N(6)-acetyltransferase activity; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; lysine N6-acetyltransferase activity
malic enzyme activity (GO:0004470)
Namespace: molecular_function
Definition: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
Synonyms: pyruvic-malic carboxylase activity
malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH.
Synonyms: 'malic' enzyme; (S)-malate:NAD+ oxidoreductase (decarboxylating); (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating); malate dehydrogenase (decarboxylating) activity; malate dehydrogenase (oxaloacetate-decarboxylating) activity; NAD-linked malic enzyme; NAD-malic enzyme activity; NAD-specific malic enzyme
Comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
malate dehydrogenase (decarboxylating) (NADP+) activity (GO:0004473)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH.
Synonyms: 'malic' enzyme; (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating); L-malate:NADP oxidoreductase activity; malate dehydrogenase (decarboxylating, NADP); malate dehydrogenase (NADP, decarboxylating); NADP-linked decarboxylating malic enzyme; NADP-malic enzyme activity; NADP-specific malate dehydrogenase activity; NADP-specific malic enzyme
Comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
malate synthase activity (GO:0004474)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+.
Synonyms: acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); glyoxylate transacetase activity; glyoxylate transacetylase activity; glyoxylic transacetase activity; L-malate glyoxylate-lyase (CoA-acetylating) activity; malate condensing enzyme activity; malate synthetase activity; malic synthetase activity; malic-condensing enzyme activity
mannose-1-phosphate guanylyltransferase (GTP) activity (GO:0004475)
Namespace: molecular_function
Definition: Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.
Synonyms: GDP-mannose pyrophosphorylase activity; GTP-mannose-1-phosphate guanylyltransferase activity; GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity; GTP:mannose-1-phosphate guanylyltransferase activity; guanosine 5'-diphospho-D-mannose pyrophosphorylase activity; guanosine diphosphomannose pyrophosphorylase activity; guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity; mannose 1-phosphate guanylyltransferase (guanosine triphosphate); mannose-1-phosphate guanylyltransferase activity; PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)
mannose-6-phosphate isomerase activity (GO:0004476)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
Synonyms: D-mannose-6-phosphate aldose-ketose-isomerase activity; D-mannose-6-phosphate ketol-isomerase activity; mannose phosphate isomerase activity; phosphohexoisomerase activity; phosphohexomutase activity; phosphomannoisomerase activity; phosphomannose isomerase activity
methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
Synonyms: 5,10-methenyl-THF cyclohydrolase activity; 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing); citrovorum factor cyclodehydrase activity; formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
methionine adenosyltransferase activity (GO:0004478)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.
Synonyms: adenosylmethionine synthetase activity; AdoMet synthetase activity; ATP-methionine adenosyltransferase activity; ATP:L-methionine S-adenosyltransferase activity; methionine S-adenosyltransferase activity; methionine-activating enzyme; S-adenosyl-L-methionine synthetase activity; S-adenosylmethionine synthase activity; S-adenosylmethionine synthetase activity
methionyl-tRNA formyltransferase activity (GO:0004479)
Namespace: molecular_function
Definition: Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.
Synonyms: 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity; conversion of met-tRNAf to fmet-tRNA; conversion of mitochondrial met-tRNAf to fmet-tRNA; formylmethionyl-transfer ribonucleic synthetase activity; methionyl ribonucleic formyltransferase activity; methionyl-transfer ribonucleate methyltransferase activity; methionyl-transfer ribonucleic transformylase activity; methionyl-transfer RNA transformylase activity; methionyl-tRNA Met formyltransferase activity; methionyl-tRNA transformylase activity; mitochondrial N-terminal peptidyl-methionine N-formylation; N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity; N-terminal peptidyl-methionine N-formylation; N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity
methylene-fatty-acyl-phospholipid synthase activity (GO:0004481)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.
Synonyms: cyclopropane synthetase activity; S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating); unsaturated-phospholipid methyltransferase activity
mRNA 5'-cap (guanine-N7-)-methyltransferase activity (GO:0004482)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
Synonyms: guanine-7-methyltransferase activity; messenger ribonucleate guanine 7-methyltransferase activity; messenger RNA guanine 7-methyltransferase activity; S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity; S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
methyltransferase cap1 activity (GO:0004483)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA or snRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA or snRNA + S-adenosyl-L-homocysteine + H+. This activity catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNAs and snRNAs.
Synonyms: messenger ribonucleate nucleoside 2'-methyltransferase activity; messenger RNA (nucleoside-2'-)-methyltransferase activity; mRNA (adenosine-2'-O-)-methyltransferase activity; mRNA (nucleoside-2'-O-)-methyltransferase activity; S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity
mRNA guanylyltransferase activity (GO:0004484)
Namespace: molecular_function
Definition: Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.
Synonyms: GTP--RNA guanylyltransferase activity; GTP:mRNA guanylyltransferase activity; messenger RNA guanylyltransferase activity; mRNA capping enzyme activity; protein lambda2
methylcrotonoyl-CoA carboxylase activity (GO:0004485)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate.
Synonyms: 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming); beta-methylcrotonyl CoA carboxylase activity; beta-methylcrotonyl coenzyme A carboxylase activity; beta-methylcrotonyl-CoA carboxylase activity; MCCC activity; methylcrotonyl coenzyme A carboxylase activity; methylcrotonyl-CoA carboxylase activity
obsolete methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity (GO:0004486)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.
Synonyms: 5,10-methylene-THF dehydrogenase activity; N5,N10-methylenetetrahydrofolate dehydrogenase activity
Comment: This term was obsoleted because it is an unnecessary grouping term.
methylenetetrahydrofolate dehydrogenase (NAD+) activity (GO:0004487)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.
Synonyms: 5,10-methylenetetrahydrofolate dehydrogenase activity; 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.
Synonyms: 5,10-methylenetetrahydrofolate:NADP oxidoreductase activity; 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity
methylenetetrahydrofolate reductase [NAD(P)H] activity (GO:0004489)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
Synonyms: 5,10-CH(2)-H(4)folate reductase activity; 5,10-CH2-H4folate reductase activity; 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity; 5,10-methylenetetrahydrofolate reductase (FADH) activity; 5,10-methylenetetrahydrofolate reductase (FADH2) activity; 5,10-methylenetetrahydrofolate reductase (NADPH) activity; 5,10-methylenetetrahydrofolate reductase activity; 5,10-methylenetetrahydrofolic acid reductase activity; 5,10-methylenetetrahydropteroylglutamate reductase activity; 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity; 5-methyltetrahydrofolate:NAD oxidoreductase activity; 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity; 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity; 5-methyltetrahydrofolate:NAD+ oxidoreductase activity; 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity; 5-methyltetrahydrofolate:NADP+ oxidoreductase activity; MetF; methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity; methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity; methylenetetrahydrofolate reductase (NADPH(2)) activity; methylenetetrahydrofolate reductase (NADPH2); methylenetetrahydrofolate reductase [NAD(P)H]; methylenetetrahydrofolate reductase activity; methylenetetrahydrofolic acid reductase activity; MTHFR activity; N(5),N(10)-methylenetetrahydrofolate reductase activity; N(5,10)-methylenetetrahydrofolate reductase activity; N5,10-methylenetetrahydrofolate reductase activity; N5,N10-methylenetetrahydrofolate reductase activity
methylglutaconyl-CoA hydratase activity (GO:0004490)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O.
Synonyms: (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming); (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity; 3-methylglutaconyl CoA hydratase activity; methylglutaconase activity; methylglutaconyl coenzyme A hydratase activity
methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (GO:0004491)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.
Synonyms: methylmalonate-semialdehyde dehydrogenase (acylating) activity; MMSA dehydrogenase activity; MSDH activity
methyl/ethyl malonyl-CoA decarboxylase activity (GO:0004492)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-methylmalonyl-CoA + H+ = CO2 + propanoyl-CoA or (2S)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2.
Synonyms: (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity; (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming); (S)-methylmalonyl-CoA carboxy-lyase activity; ethylmalonyl-CoA decarboxylase activity; methylmalonyl-coenzyme A decarboxylase activity
methylmalonyl-CoA epimerase activity (GO:0004493)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.
Synonyms: 2-methyl-3-oxopropanoyl-CoA 2-epimerase activity; DL-methylmalonyl-CoA racemase activity; methylmalonyl coenzyme A racemase activity; methylmalonyl-CoA 2-epimerase activity; methylmalonyl-CoA racemase activity
methylmalonyl-CoA mutase activity (GO:0004494)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.
Synonyms: (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity; (R)-methylmalonyl-CoA CoA-carbonylmutase activity; (S)-methylmalonyl-CoA mutase activity; methylmalonyl coenzyme A carbonylmutase activity; methylmalonyl coenzyme A mutase activity; methylmalonyl-CoA CoA-carbonyl mutase activity
obsolete mevaldate reductase activity (GO:0004495)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
mevalonate kinase activity (GO:0004496)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+.
Synonyms: ATP:(R)-mevalonate 5-phosphotransferase activity; ATP:mevalonate 5-phosphotransferase activity; mevalonate 5-phosphotransferase activity; mevalonate kinase (phosphorylating); mevalonate phosphokinase activity; mevalonic acid kinase activity; mevalonic kinase activity; MVA kinase activity
monooxygenase activity (GO:0004497)
Namespace: molecular_function
Definition: Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
Synonyms: hydroxylase activity; mixed-function oxidase
calcidiol 1-monooxygenase activity (GO:0004498)
Namespace: molecular_function
Definition: Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+.
Synonyms: 1-hydroxylase-25-hydroxyvitamin D3 activity; 25-hydroxy D3-1alpha-hydroxylase activity; 25-hydroxy vitamin D3 1-alpha-hydroxylase activity; 25-hydroxycholecalciferol 1-hydroxylase activity; 25-hydroxycholecalciferol 1-monooxygenase activity; 25-hydroxycholecalciferol 1alpha-hydroxylase activity; 25-hydroxycholecalciferol-1-hydroxylase activity; 25-hydroxyvitamin D-1 alpha hydroxylase activity; 25-hydroxyvitamin D3 1alpha-hydroxylase activity; 25-OHD-1 alpha-hydroxylase activity; calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating); cytochrome P450 CYP27B
N,N-dimethylaniline monooxygenase activity (GO:0004499)
Namespace: molecular_function
Definition: Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
Synonyms: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity; dimethylaniline monooxygenase (N-oxide-forming) activity; dimethylaniline N-oxidase activity; dimethylaniline oxidase activity; DMA oxidase activity; FAD-containing monooxygenase activity; flavin mixed function oxidase activity; flavin monooxygenase activity; flavin-containing monooxygenase activity; FMO activity; methylphenyltetrahydropyridine N-monooxygenase activity; mixed-function amine oxidase activity; N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming); Ziegler's enzyme
dopamine beta-monooxygenase activity (GO:0004500)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O.
Synonyms: (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity; 3,4-dihydroxyphenethylamine beta-oxidase activity; 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating); 4-(2-aminoethyl)pyrocatechol beta-oxidase activity; dopa beta-hydroxylase activity; dopamine b-hydroxylase activity; dopamine beta-hydroxylase activity; dopamine beta-oxidase activity; dopamine hydroxylase activity; dopamine-B-hydroxylase activity; MDBH (membrane-associated dopamine beta-monooxygenase); oxygenase, dopamine beta-mono-; phenylamine beta-hydroxylase activity; SDBH (soluble dopamine beta-monooxygenase)
kynurenine 3-monooxygenase activity (GO:0004502)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+.
Synonyms: kynurenine 3-hydroxylase activity; kynurenine hydroxylase activity; L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating); L-kynurenine-3-hydroxylase activity
tyrosinase activity (GO:0004503)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.
Synonyms: catecholase; chlorogenic acid oxidase activity; chlorogenic oxidase activity; cresolase activity; dopa oxidase; L-tyrosine monooxygenase activity; monophenol monooxidase activity; monophenol monooxygenase activity; monophenol oxidase activity; monophenol oxygenase; monophenolase activity; N-acetyl-6-hydroxytryptophan oxidase activity; o-diphenol oxidase activity; o-diphenol oxidoreductase; o-diphenol:O2 oxidoreductase activity; phenol oxidase activity; phenolase activity; prophenol oxidase activity; prophenoloxidase activity; pyrocatechol oxidase; tyrosine-dopa oxidase activity
Comment: In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children.
phenylalanine 4-monooxygenase activity (GO:0004505)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
Synonyms: L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating); PAH activity; phenylalaninase activity; phenylalanine 4-hydroxylase activity; phenylalanine hydroxylase activity
squalene monooxygenase activity (GO:0004506)
Namespace: molecular_function
Definition: Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+.
Synonyms: squalene 2,3-oxidocyclase activity; squalene epoxidase activity; squalene hydroxylase activity; squalene oxydocyclase activity; squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity; squalene-2,3-epoxidase activity; squalene-2,3-epoxide cyclase activity
steroid 11-beta-monooxygenase activity (GO:0004507)
Namespace: molecular_function
Definition: Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
Synonyms: cytochrome P450 CYP11B1; cytochrome P450 CYP11B2; cytochrome p450 XIB1 activity; oxygenase, steroid 11beta -mono-; steroid 11-beta-hydroxylase activity; steroid 11-beta/18-hydroxylase activity; steroid 11beta-hydroxylase activity; steroid 11beta-monooxygenase activity; steroid 11beta/18-hydroxylase activity; steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
steroid 21-monooxygenase activity (GO:0004509)
Namespace: molecular_function
Definition: Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.
Synonyms: 21-hydroxylase activity; cytochrome P450 CYP21A1; cytochrome p450 XXIA1 activity; steroid 21-hydroxylase activity; steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
tryptophan 5-monooxygenase activity (GO:0004510)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.
Synonyms: indoleacetic acid-5-hydroxylase activity; L-tryptophan hydroxylase activity; L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating); tryptophan 5-hydroxylase activity; tryptophan hydroxylase activity
tyrosine 3-monooxygenase activity (GO:0004511)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.
Synonyms: L-tyrosine hydroxylase activity; L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating); tyrosine 3-hydroxylase activity; tyrosine hydroxylase activity
inositol-3-phosphate synthase activity (GO:0004512)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.
Synonyms: 1L-myo-inositol-1-phosphate lyase (isomerizing); D-glucose 6-phosphate cycloaldolase activity; glucocycloaldolase activity; glucose 6-phosphate cyclase activity; glucose-6-phosphate inositol monophosphate cycloaldolase activity; inositol 1-phosphate synthatase activity; inositol 1-phosphate synthetase activity
nicotinate-nucleotide diphosphorylase (carboxylating) activity (GO:0004514)
Namespace: molecular_function
Definition: Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate.
Synonyms: NAD pyrophosphorylase activity; nicotinate mononucleotide pyrophosphorylase (carboxylating); nicotinate-nucleotide pyrophosphorylase (carboxylating) activity; nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating); QAPRTase activity; quinolinate phosphoribosyltransferase (decarboxylating) activity; quinolinic acid phosphoribosyltransferase activity; quinolinic phosphoribosyltransferase activity