LiteFold/GO huggingface dataset:
histone H3K9 dimethyltransferase activity (GO:0140942)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2.
Synonyms: histone H3-K9 dimethylation; histone H3K9 dimethylase activity; histone H3K9 dimethylation; histone H3K9 mono/dimethylase activity; histone lysine N-dimethyltransferase activity (H3-K9 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H4K20 trimethyltransferase activity (GO:0140943)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3.
Synonyms: histone H4K20 trimethylase activity; histone H4K20 trimethylation; histone lysine N-trimethyltransferase activity (H4-K20 specific)
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H4K20 monomethyltransferase activity (GO:0140944)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me.
Synonyms: histone H4-K20 methylation; histone H4K20 methylase activity; histone H4K20 methylation; histone H4K20 monomethylation; histone lysine N-monomethyltransferase activity (H4-K20 specific)
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H3K4 monomethyltransferase activity (GO:0140945)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me.
Synonyms: histone H3K4 monomethylase activity; histone H4-K4 methylation; histone H4K4 methylation; histone lysine N-monomethyltransferase activity (H3-K4 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K4 dimethyltransferase activity (GO:0140946)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2.
Synonyms: histone H3-K4 dimethylation; histone H3K4 dimethylase activity; histone H3K4 dimethylation; histone lysine N-dimethyltransferase activity (H3-K4 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K9me2 methyltransferase activity (GO:0140947)
Namespace: molecular_function
Definition: Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.
Synonyms: histone dimethyl-lysine(H3K9) N-methyltransferase activity (H3-K9 specific); histone H3-K9 trimethylation; histone H3K9 trimethylation; histone H3K9me2 methylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K9 trimethyltransferase activity (GO:0140949)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.
Synonyms: histone H3-K9 trimethylation; histone H3K9 mono/di/trimethylase activity; histone H3K9 trimethylase activity; histone H3K9 trimethylation; histone lysine N-trimethyltransferase activity (H3-K9 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2A deubiquitinase activity (GO:0140950)
Namespace: molecular_function
Definition: A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated.
Synonyms: histone H2A deubiquitination
histone H3K27 trimethyltransferase activity (GO:0140951)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3.
Synonyms: histone H3-K27 trimethylase activity; histone H3-K27 trimethylation; histone H3K27 mono/di/trimethylase activity; histone H3K27 trimethylase activity; histone H3K27 trimethylation; histone lysine N-trimethyltransferase activity (H3-K27 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K27 dimethyltransferase activity (GO:0140952)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.
Synonyms: histone H3-K27 dimethylase activity; histone H3-K27 dimethylation; histone H3K27 dimethylase activity; histone H3K27 dimethylation; histone H3K27 mono/dimethylase activity; histone lysine N-dimethyltransferase activity (H3-K27 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K27 monomethyltransferase activity (GO:0140953)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me.
Synonyms: histone H3-K27 methylation; histone H3-K27 monomethylase activity; histone H3K27 methylation; histone H3K27 monomethylase activity; histone lysine N-monomethyltransferase activity (H3-K27 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K36 dimethyltransferase activity (GO:0140954)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2.
Synonyms: histone H3-K36 dimethylation; histone H3K36 dimethylase activity; histone H3K36 dimethylation; histone H3K36 mono/dimethylase activity; histone lysine N-dimethyltransferase activity (H3-K36 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K36 trimethyltransferase activity (GO:0140955)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3.
Synonyms: histone H3-K36 trimethylation; histone H3K36 mono/di/trimethylase activity; histone H3K36 trimethylase activity; histone H3K36 trimethylation; histone lysine N-trimethyltransferase activity (H3-K36 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K79 trimethyltransferase activity (GO:0140956)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3.
Synonyms: histone H3-K79 trimethylation; histone H3K79 trimethylase activity; histone H3K79 trimethylation; histone lysine N-trimethyltransferase activity (H3-K79 specific); histone trimethylase activity (H3-K79 specific); histone trimethyltransferase activity (H3-K79 specific); histone-H3K79 trimethyltransferase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
target-directed miRNA degradation (GO:0140958)
Namespace: biological_process
Definition: The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases.
Synonyms: target-directed microRNA degradation; TDMD
obsolete base-pairing target-directed miRNA suppressor activity (GO:0140959)
Namespace: molecular_function
Definition: OBSOLETE. An inhibitor activity that acts by base-pairing with a miRNA, exposing it to nuclease-mediated degradation.
Synonyms: base-pairing target-directed microRNA suppressor activity
Comment: This term was obsoleted because it represents the same function as miRNA inhibitor activity, GO:0140869.
cellular detoxification of metal ion (GO:0140961)
Namespace: biological_process
Definition: Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion.
Synonyms: cellular detoxification of metal cation
multicellular organismal-level chemical homeostasis (GO:0140962)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
Synonyms: multicellular organism level chemical homeostasis; organismal level chemical homeostasis
obsolete multicellular organismal-level auxin homeostasis (GO:0140963)
Namespace: biological_process
Definition: OBSOLETE. A chemical homeostatic process involved in the maintenance of a steady state level of auxin within extracellular body fluids, such as the xylem or phloem of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
Synonyms: auxin homeostasis; multicellular organismal auxin homeostasis
Comment: This term was obsoleted because it was created by error.
intracellular auxin homeostasis (GO:0140964)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of auxin within a cell.
Synonyms: auxin homeostasis; cellular auxin homeostasis
secondary piRNA processing (GO:0140965)
Namespace: biological_process
Definition: A process leading to the generation of a functional secondary piRNA, involving a self-perpetuating piRNA loop, often called the ping-pong cycle, in which piRNAs are amplified by pairing with complementary transcripts (for example the transposable element mRNA target). In Drosophila, the processing involves the piwi proteins aubergine and Argonaute 3 and in mice, the piwi proteins Piwil2 and Piwil4.
Synonyms: ping-pong amplification; ping-pong derived piRNA; secondary piRNA biogenesis; secondary PIWI-associated RNA processing
piRNA-mediated heterochromatin formation (GO:0140966)
Namespace: biological_process
Definition: The formation of heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a Piwi-associated RNA (piRNA).
Synonyms: piRNA-directed heterochromatin formation; piwiRNA-directed heterochromatin formation
manganese import into cell (GO:0140967)
Namespace: biological_process
Definition: The directed movement of mangnanese ions from outside of a cell into a cell.
Synonyms: manganese influx
polyspecific organic cation:proton antiporter activity (GO:0140968)
Namespace: molecular_function
Definition: Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics.
Synonyms: proton:polyspecific organic cation antiporter activity
determination of lung left/right asymmetry (GO:0140969)
Namespace: biological_process
Definition: Determination of the asymmetric location of the lungs with respect to the left and right halves of the organism.
AIM2 inflammasome complex assembly (GO:0140970)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form the AIM2 inflammasome complex.
regulation of AIM2 inflammasome complex assembly (GO:0140971)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of AIM2 inflammasome complex assembly.
negative regulation of AIM2 inflammasome complex assembly (GO:0140972)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of AIM2 inflammasome complex assembly.
positive regulation of AIM2 inflammasome complex assembly (GO:0140973)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of AIM2 inflammasome complex assembly.
disruption of cellular anatomical structure in another organism (GO:0140975)
Namespace: biological_process
Definition: The disruption of a cellular component of another organism, leading to damage or temporary subversion of that structure. In some cases this can cause malfunctioning of the cells and death of the target organism.
Synonyms: disruption of cellular component of another organism
host defense response against symbiont-mediated perturbation of plasma membrane integrity (GO:0140976)
Namespace: biological_process
Definition: The cellular processes and signaling pathways by which a cell responds to disruption of the integrity of its plasma membrane by another organism. Some toxins produced by other organisms can form pores in membranes, or affect the membrane permeability.
Synonyms: defense response against disruption of plasma membrane integrity; defense response against perturbation of plasma membrane integrity
cellular detoxification of acetone (GO:0140977)
Namespace: biological_process
Definition: Any process carried out at the cellular level that reduces or removes the toxicity of acetone. These may include chemical modification, for example to methylglyoxal.
mitochondrial large ribosomal subunit binding (GO:0140978)
Namespace: molecular_function
Definition: Binding to a mitochondrial large ribosomal subunit.
Synonyms: mitochondrial ribosomal large subunit binding
intracellular nucleotide homeostasis (GO:0140979)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of nucleotides within a cell.
intracellular nucleoside homeostasis (GO:0140980)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of nucleosides within a cell.
medium-chain fatty acid omega-hydroxylase activity (GO:0140981)
Namespace: molecular_function
Definition: Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
detoxification of aluminum ion (GO:0140982)
Namespace: biological_process
Definition: Any process that reduce or remove the toxicity of aluminum ions. These can include transport of the aluminum away from sensitive areas, sequesteration, or chemical modification to an inert form.
Synonyms: aluminum ion homeostasis
calcium:manganese antiporter activity (GO:0140983)
Namespace: molecular_function
Definition: Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in).
Synonyms: manganese:calcium antiporter activity
histone H4K12 methyltransferase activity (GO:0140984)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein.
Synonyms: histone H4 lysine 12-specific methyltransferase activity; histone H4K12 methylase activity; histone H4K12 methylation; histone lysine N-methyltransferase activity (H4-K12 specific); histone methylase activity (H4-K12 specific); histone methyltransferase activity (H4-K12 specific); histone-H4K12 methyltransferase activity
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
G protein-coupled chemorepellent receptor activity (GO:0140985)
Namespace: molecular_function
Definition: Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G protein chemorepellent receptor activity; G-protein chemorepellent receptor activity; G-protein coupled chemorepellent receptor activity
G protein-coupled chemorepellent receptor signaling pathway (GO:0140986)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a chemorepellent binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization.
ATP:phosphate antiporter activity (GO:0140987)
Namespace: molecular_function
Definition: Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + phosphate(in) = ATP(in) + phosphate(out).
Synonyms: ATP:inorganic phosphate antiporter activity; inorganic phosphate:ATP antiporter activity
7-deoxyloganate 7-hydroxylase activity (GO:0140989)
Namespace: molecular_function
Definition: Catalysis of the reaction: 7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganate + oxidized [NADPH-hemoprotein reductase].
primary piRNA processing (GO:0140990)
Namespace: biological_process
Definition: The process involved in converting precursor piRNAs into non-overlapping, contiguous primary piRNAs (approximately 24-30-nt piRNAs with a preference for a 5' uridine (U) via the endonucleolytic activity of cytosolic PIWI. This may include pre-piRNA maturation of 3' ends by trimming and 2'-O-methylation.
piRNA-mediated gene silencing by mRNA destabilization (GO:0140991)
Namespace: biological_process
Definition: A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping.
histone modifying activity (GO:0140993)
Namespace: molecular_function
Definition: A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression.