LiteFold/GO huggingface dataset:
obsolete receptor signaling protein serine/threonine kinase signaling protein activity (GO:0005076)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: receptor signaling protein serine/threonine kinase signaling protein activity; receptor signalling protein serine/threonine kinase signalling protein activity
Comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
obsolete protein kinase A anchoring activity (GO:0005079)
Namespace: molecular_function
Definition: OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location.
Synonyms: A-kinase anchor protein activity; AKAP activity; protein kinase A anchoring activity
Comment: This term was made obsolete because it represents a combination of process and function information.
protein kinase C binding (GO:0005080)
Namespace: molecular_function
Definition: Binding to protein kinase C.
Synonyms: PKC alpha binding; PKC binding; PKC delta binding; PKC eta binding; protein kinase C alpha binding; protein kinase C delta binding; protein kinase C eta binding
obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity (GO:0005081)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: receptor signaling protein serine/threonine phosphatase signaling protein activity; receptor signalling protein serine/threonine phosphatase signalling protein activity
Comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
obsolete receptor signaling protein tyrosine phosphatase signaling protein activity (GO:0005082)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: receptor signaling protein tyrosine phosphatase signaling protein activity; receptor signalling protein tyrosine phosphatase signalling protein activity
Comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
guanyl-nucleotide exchange factor activity (GO:0005085)
Namespace: molecular_function
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Synonyms: ARF guanyl-nucleotide exchange factor activity; cAMP-dependent guanyl-nucleotide exchange factor activity; GDP-dissociation stimulator activity; GDS; GEF; GNRP; guanyl-nucleotide release factor activity; guanyl-nucleotide releasing factor; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Ral guanyl-nucleotide exchange factor activity; Ran guanyl-nucleotide exchange factor activity; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity; Rho guanine nucleotide exchange factor; Rho guanyl-nucleotide exchange factor activity; RhoGEF; Sar guanyl-nucleotide exchange factor activity
guanyl-nucleotide exchange factor adaptor activity (GO:0005091)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
GDP-dissociation inhibitor activity (GO:0005092)
Namespace: molecular_function
Definition: Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
Synonyms: GDI
Rab GDP-dissociation inhibitor activity (GO:0005093)
Namespace: molecular_function
Definition: Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.
Rho GDP-dissociation inhibitor activity (GO:0005094)
Namespace: molecular_function
Definition: Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.
GTPase inhibitor activity (GO:0005095)
Namespace: molecular_function
Definition: Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
Synonyms: GIP
GTPase activator activity (GO:0005096)
Namespace: molecular_function
Definition: Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
Synonyms: ARF GAP activity; ARF GTPase activator activity; GAP activity; Rab GAP activity; Rab GTPase activator activity; Rac GAP activity; Rac GTPase activator activity; Ral GAP activity; Ral GTPase activator activity; Ran GAP activity; Ran GTPase activator activity; RanGAP; Rap GAP activity; Rap GTPase activator activity; Ras GAP activity; Ras GTPase activator activity; Rho GAP activity; Rho GTPase activator activity; Sar GAP activity; Sar GTPase activator activity
Comment: Note that the name Sar derives from 'secretion-associated, Ras-related'.
signaling receptor binding (GO:0005102)
Namespace: molecular_function
Definition: Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Synonyms: receptor binding; receptor ligand; receptor-associated protein activity
Comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.
type 1 fibroblast growth factor receptor binding (GO:0005105)
Namespace: molecular_function
Definition: Binding to a type 1 fibroblast growth factor receptor (FGFR1).
Synonyms: breathless binding; breathless ligand; FGFR1 binding; FGFR1 ligand; type 1 fibroblast growth factor receptor ligand
Comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1).
obsolete ephrin (GO:0005106)
Namespace: molecular_function
Definition: OBSOLETE. A class of proteins that interact with the ephrin receptors.
Synonyms: ephrin
Comment: This term was made obsolete because it refers to a class of gene products.
obsolete GPI-linked ephrin (GO:0005107)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: GPI-linked ephrin
Comment: This term was made obsolete because it refers to a class of gene products.
frizzled binding (GO:0005109)
Namespace: molecular_function
Definition: Binding to a frizzled (fz) receptor.
Synonyms: frizzled ligand; frizzled-2 binding; frizzled-2 ligand; fz binding; fz ligand; fz2 binding; fz2 ligand
type 2 fibroblast growth factor receptor binding (GO:0005111)
Namespace: molecular_function
Definition: Binding to a type 2 fibroblast growth factor receptor (FGFR2).
Synonyms: FGFR2 binding; FGFR2 ligand; heartless binding; heartless ligand; type 2 fibroblast growth factor receptor ligand
Comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2).
Notch binding (GO:0005112)
Namespace: molecular_function
Definition: Binding to a Notch (N) protein, a surface receptor.
Synonyms: N binding; N ligand; Notch ligand; Notch receptor binding
patched binding (GO:0005113)
Namespace: molecular_function
Definition: Binding to a patched (ptc) protein, a receptor for hedgehog proteins.
Synonyms: patched ligand; ptc binding; ptc ligand
type II transforming growth factor beta receptor binding (GO:0005114)
Namespace: molecular_function
Definition: Binding to a type II transforming growth factor beta receptor.
Synonyms: punt binding; punt ligand; TGF-beta type II binding; transforming growth factor beta ligand binding to type II receptor; transforming growth factor beta receptor type II binding; type II TGF-beta binding
receptor tyrosine kinase-like orphan receptor binding (GO:0005115)
Namespace: molecular_function
Definition: Binding to a receptor tyrosine kinase-like orphan receptor (Ror).
Synonyms: receptor tyrosine kinase-like orphan receptor ligand; Ror binding; Ror ligand
wishful thinking binding (GO:0005117)
Namespace: molecular_function
Definition: Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor.
Synonyms: SE20 receptor binding; wishful thinking ligand; Wit binding; Wit ligand
sevenless binding (GO:0005118)
Namespace: molecular_function
Definition: Binding to a sevenless (sev) protein, a receptor tyrosine kinase.
Synonyms: sev binding; sev ligand; sevenless ligand
smoothened binding (GO:0005119)
Namespace: molecular_function
Definition: Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.
Synonyms: smo binding; smo ligand; smoothened ligand
Toll binding (GO:0005121)
Namespace: molecular_function
Definition: Binding to a Toll protein, a transmembrane receptor.
Synonyms: Tl binding; Toll ligand; Toll receptor binding
torso binding (GO:0005122)
Namespace: molecular_function
Definition: Binding to a torso (tor) protein, a receptor tyrosine kinase.
Synonyms: tor binding; tor ligand; torso ligand
death receptor binding (GO:0005123)
Namespace: molecular_function
Definition: Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
Synonyms: APO binding; death receptor adaptor protein activity; death receptor interacting protein activity; death receptor ligand; death receptor-associated factor activity; DR binding; EDAR binding; FAS binding; KILLER binding; NGFR binding; TNFR1 binding; TRAIL binding
cytokine receptor binding (GO:0005126)
Namespace: molecular_function
Definition: Binding to a cytokine receptor.
Synonyms: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
ciliary neurotrophic factor receptor binding (GO:0005127)
Namespace: molecular_function
Definition: Binding to a ciliary neurotrophic factor receptor.
Synonyms: ciliary neurotrophic factor; ciliary neurotrophic factor receptor ligand
erythropoietin receptor binding (GO:0005128)
Namespace: molecular_function
Definition: Binding to an erythropoietin receptor.
Synonyms: erythropoietin; erythropoietin receptor ligand
granulocyte macrophage colony-stimulating factor receptor binding (GO:0005129)
Namespace: molecular_function
Definition: Binding to a granulocyte macrophage colony-stimulating factor receptor.
Synonyms: GM-CSF receptor binding; GM-CSF receptor ligand; GMC-SF receptor ligand; granulocyte macrophage colony stimulating factor receptor binding; granulocyte macrophage colony-stimulating factor; granulocyte macrophage colony-stimulating factor receptor ligand
granulocyte colony-stimulating factor receptor binding (GO:0005130)
Namespace: molecular_function
Definition: Binding to a granulocyte colony-stimulating factor receptor.
Synonyms: G-CSF receptor ligand; GC-SF receptor ligand; granulocyte colony stimulating factor receptor binding; granulocyte colony-stimulating factor; granulocyte colony-stimulating factor receptor ligand
growth hormone receptor binding (GO:0005131)
Namespace: molecular_function
Definition: Binding to a growth hormone receptor.
Synonyms: growth hormone; growth hormone receptor ligand
type I interferon receptor binding (GO:0005132)
Namespace: molecular_function
Definition: Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).
Synonyms: IFNAR binding; IFNAR1 binding; IFNAR2 binding; interferon-alpha/beta; interferon-alpha/beta receptor binding; interferon-alpha/beta receptor ligand
type II interferon receptor binding (GO:0005133)
Namespace: molecular_function
Definition: Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma.
Synonyms: interferon-gamma; interferon-gamma receptor binding; interferon-gamma receptor ligand
interleukin-3 receptor binding (GO:0005135)
Namespace: molecular_function
Definition: Binding to an interleukin-3 receptor.
Synonyms: IL-3; interleukin-3 receptor ligand
interleukin-4 receptor binding (GO:0005136)
Namespace: molecular_function
Definition: Binding to an interleukin-4 receptor.
Synonyms: IL-4; interleukin-4 receptor ligand
interleukin-5 receptor binding (GO:0005137)
Namespace: molecular_function
Definition: Binding to an interleukin-5 receptor.
Synonyms: IL-5; interleukin-5 receptor ligand
interleukin-7 receptor binding (GO:0005139)
Namespace: molecular_function
Definition: Binding to an interleukin-7 receptor.
Synonyms: IL-7; interleukin-7 receptor ligand
interleukin-10 receptor binding (GO:0005141)
Namespace: molecular_function
Definition: Binding to an interleukin-10 receptor.
Synonyms: IL-10; interleukin-10 receptor ligand
interleukin-11 receptor binding (GO:0005142)
Namespace: molecular_function
Definition: Binding to an interleukin-11 receptor.
Synonyms: IL-11; interleukin-11 receptor ligand
interleukin-13 receptor binding (GO:0005144)
Namespace: molecular_function
Definition: Binding to an interleukin-13 receptor.
Synonyms: IL-13; interleukin-13 receptor ligand
obsolete interleukin-14 receptor binding (GO:0005145)
Namespace: molecular_function
Definition: OBSOLETE. Binding to an interleukin-14 receptor.
Synonyms: IL-14; interleukin-14 receptor ligand
Comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
leukemia inhibitory factor receptor binding (GO:0005146)
Namespace: molecular_function
Definition: Binding to an leukemia inhibitory factor receptor.
Synonyms: leukemia inhibitory factor; leukemia inhibitory factor receptor ligand
oncostatin-M receptor binding (GO:0005147)
Namespace: molecular_function
Definition: Binding to an oncostatin-M receptor.
Synonyms: oncostatin-M; oncostatin-M receptor ligand
prolactin receptor binding (GO:0005148)
Namespace: molecular_function
Definition: Binding to a prolactin receptor.
Synonyms: prolactin; prolactin receptor ligand
interleukin-1 receptor binding (GO:0005149)
Namespace: molecular_function
Definition: Binding to an interleukin-1 receptor.
Synonyms: IL-1; interleukin-1 receptor ligand
interleukin-1, type I receptor binding (GO:0005150)
Namespace: molecular_function
Definition: Binding to a Type I interleukin-1 receptor.
Synonyms: IL-1 type I; interleukin-1, type I receptor ligand
interleukin-1, type II receptor binding (GO:0005151)
Namespace: molecular_function
Definition: Binding to a Type II interleukin-1 receptor.
Synonyms: IL-1 type II; interleukin-1, type II receptor ligand
interleukin-1 receptor antagonist activity (GO:0005152)
Namespace: molecular_function
Definition: Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.
Synonyms: IL-1ra
interleukin-8 receptor binding (GO:0005153)
Namespace: molecular_function
Definition: Binding to an interleukin-8 receptor.
Synonyms: IL-8; interleukin-8 receptor ligand
epidermal growth factor receptor binding (GO:0005154)
Namespace: molecular_function
Definition: Binding to an epidermal growth factor receptor.
Synonyms: EGF; EGF receptor binding; EGF receptor ligand; EGFR binding; epidermal growth factor; epidermal growth factor receptor ligand; TGF-alpha receptor binding; TGFalpha receptor binding; transforming growth factor alpha; transforming growth factor alpha receptor binding; transforming growth factor alpha receptor ligand
obsolete epidermal growth factor receptor activating ligand activity (GO:0005155)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: EGF receptor activating ligand activity; EGFR activating ligand activity; epidermal growth factor receptor activating ligand activity
Comment: This term was made obsolete because it represents both a biological process and a molecular function.
obsolete epidermal growth factor receptor inhibiting ligand activity (GO:0005156)
Namespace: molecular_function
Definition: OBSOLETE. This term was not defined before being made obsolete.
Synonyms: EGF receptor inhibiting ligand activity; EGFR inhibiting ligand activity; epidermal growth factor receptor inhibiting ligand activity
Comment: This term was made obsolete because it represents both a biological process and a molecular function.
macrophage colony-stimulating factor receptor binding (GO:0005157)
Namespace: molecular_function
Definition: Binding to a macrophage colony-stimulating factor receptor.
Synonyms: M-CSF receptor binding; macrophage colony stimulating factor receptor binding; macrophage colony-stimulating factor receptor ligand
insulin receptor binding (GO:0005158)
Namespace: molecular_function
Definition: Binding to an insulin receptor.
Synonyms: insulin receptor ligand
insulin-like growth factor receptor binding (GO:0005159)
Namespace: molecular_function
Definition: Binding to an insulin-like growth factor receptor.
Synonyms: IGF receptor binding; insulin-like growth factor; insulin-like growth factor receptor ligand
transforming growth factor beta receptor binding (GO:0005160)
Namespace: molecular_function
Definition: Binding to a transforming growth factor beta receptor.
Synonyms: activin; inhibin; TGF-beta receptor binding; TGFbeta receptor binding; transforming growth factor beta; transforming growth factor beta ligand binding to type I receptor; transforming growth factor beta ligand binding to type II receptor; transforming growth factor beta receptor anchoring activity; transforming growth factor beta receptor ligand
platelet-derived growth factor receptor binding (GO:0005161)
Namespace: molecular_function
Definition: Binding to a platelet-derived growth factor receptor.
Synonyms: PDGF; PDGF receptor binding; PDGFR binding; platelet-derived growth factor; platelet-derived growth factor receptor ligand
nerve growth factor receptor binding (GO:0005163)
Namespace: molecular_function
Definition: Binding to a nerve growth factor receptor.
Synonyms: nerve growth factor receptor ligand; neurotrophin; NGF receptor binding
tumor necrosis factor receptor binding (GO:0005164)
Namespace: molecular_function
Definition: Binding to a tumor necrosis factor receptor.
Synonyms: TNF receptor binding; tumor necrosis factor; tumor necrosis factor receptor ligand
neurotrophin receptor binding (GO:0005165)
Namespace: molecular_function
Definition: Binding to a neurotrophin receptor.
Synonyms: neurotrophin; neurotrophin receptor ligand
neurotrophin p75 receptor binding (GO:0005166)
Namespace: molecular_function
Definition: Binding to a neurotrophin p75 receptor.
Synonyms: neurotrophin p75 receptor ligand
neurotrophin TRK receptor binding (GO:0005167)
Namespace: molecular_function
Definition: Binding to a neurotrophin TRK receptor.
Synonyms: neurotrophin TRK receptor ligand
neurotrophin TRKA receptor binding (GO:0005168)
Namespace: molecular_function
Definition: Binding to a neurotrophin TRKA receptor.
Synonyms: neurotrophin TRKA receptor ligand
neurotrophin TRKB receptor binding (GO:0005169)
Namespace: molecular_function
Definition: Binding to a neurotrophin TRKB receptor.
Synonyms: neurotrophin TRKB receptor ligand
neurotrophin TRKC receptor binding (GO:0005170)
Namespace: molecular_function
Definition: Binding to a neurotrophin TRKC receptor.
Synonyms: neurotrophin TRKC receptor ligand
hepatocyte growth factor receptor binding (GO:0005171)
Namespace: molecular_function
Definition: Binding to an hepatocyte growth factor receptor.
Synonyms: hepatocyte growth factor; hepatocyte growth factor receptor ligand; HGF receptor binding
vascular endothelial growth factor receptor binding (GO:0005172)
Namespace: molecular_function
Definition: Binding to a vascular endothelial growth factor receptor.
Synonyms: vascular endothelial growth factor; vascular endothelial growth factor receptor ligand; VEGF receptor binding; VEGFR binding
stem cell factor receptor binding (GO:0005173)
Namespace: molecular_function
Definition: Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
Synonyms: KIT binding; SCF; SCFR binding; stem cell factor; stem cell factor receptor ligand
CD40 receptor binding (GO:0005174)
Namespace: molecular_function
Definition: Binding to CD40, a receptor found on the surface of all B-lymphocytes.
CD27 receptor binding (GO:0005175)
Namespace: molecular_function
Definition: Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells.
ErbB-2 class receptor binding (GO:0005176)
Namespace: molecular_function
Definition: Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.
Synonyms: ErbB-2 class receptor ligand; HER2 receptor binding; HER2 receptor ligand; Neu receptor binding; Neu receptor ligand
obsolete neuroligin (GO:0005177)
Namespace: molecular_function
Definition: OBSOLETE. A class of ligands for neurexins.
Synonyms: neuroligin
hormone activity (GO:0005179)
Namespace: molecular_function
Definition: The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
Synonyms: cAMP generating peptide activity; glycopeptide hormone; lipopeptide hormone; peptide hormone
Comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.
obsolete peptide hormone (GO:0005180)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: peptide hormone
Comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
obsolete lipopeptide hormone (GO:0005182)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: lipopeptide hormone
Comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
gonadotropin hormone-releasing hormone activity (GO:0005183)
Namespace: molecular_function
Definition: The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.
Synonyms: GnRH activity; gonadotrophin hormone-releasing hormone activity; LH/FSH-RF; LHRH activity; luteinizing hormone-releasing factor activity; luteinizing hormone-releasing hormone activity; luteinizing hormone/follicle-stimulating hormone releasing factor activity
neuropeptide hormone activity (GO:0005184)
Namespace: molecular_function
Definition: The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
Synonyms: neurohormone
obsolete storage protein (GO:0005187)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: storage protein
Comment: This term was made obsolete because it describes a cellular location rather than a function.
obsolete larval serum protein (sensu Insecta) (GO:0005188)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: arylphorin; larval serum protein (sensu Insecta)
Comment: This term was made obsolete because it describes presence in body fluids rather than an activity.