LiteFold/GO huggingface dataset:
transcription initiation-coupled chromatin remodeling (GO:0045815)
Namespace: biological_process
Definition: An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA.
Synonyms: chromatin-mediated maintenance of transcription; DNA replication-independent chromatin organization; epigenetic maintenance of chromatin in transcription-competent conformation; euchromatin assembly; euchromatin organisation; euchromatin organization; long-term maintenance of gene activation; maintenance of chromatin in transcription-competent conformation; transciptional initiation-coupled chromatin remodeling; transcription initiation coupled chromatin remodeling; transcription initiation coupled chromatin remodelling; transcriptional initiation-coupled chromatin remodeling; transcriptional initiation-coupled chromatin remodelling
Comment: This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. Do not confuse with GO:0140673 ; transcriptional elongation-coupled chromatin remodeling, which describes the reforming of chromatin after RNA polymerase II passage.
negative regulation of glycogen catabolic process (GO:0045818)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.
Synonyms: down regulation of glycogen catabolic process; down-regulation of glycogen catabolic process; downregulation of glycogen catabolic process; inhibition of glycogen catabolic process; negative regulation of glycogen breakdown; negative regulation of glycogen catabolism; negative regulation of glycogen degradation; negative regulation of glycogenolysis
positive regulation of glycogen catabolic process (GO:0045819)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.
Synonyms: activation of glycogen catabolic process; positive regulation of glycogen breakdown; positive regulation of glycogen catabolism; positive regulation of glycogen degradation; positive regulation of glycogenolysis; stimulation of glycogen catabolic process; up regulation of glycogen catabolic process; up-regulation of glycogen catabolic process; upregulation of glycogen catabolic process
negative regulation of glycolytic process (GO:0045820)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
Synonyms: down regulation of glycolysis; down-regulation of glycolysis; downregulation of glycolysis; inhibition of glycolysis
positive regulation of glycolytic process (GO:0045821)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of glycolysis.
Synonyms: activation of glycolysis; stimulation of glycolysis; up regulation of glycolysis; up-regulation of glycolysis; upregulation of glycolysis
negative regulation of heart contraction (GO:0045822)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
Synonyms: down regulation of heart contraction; down-regulation of heart contraction; downregulation of heart contraction; inhibition of heart contraction; negative regulation of cardiac contraction
positive regulation of heart contraction (GO:0045823)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of heart contraction.
Synonyms: activation of heart contraction; positive regulation of cardiac contraction; stimulation of heart contraction; up regulation of heart contraction; up-regulation of heart contraction; upregulation of heart contraction
negative regulation of innate immune response (GO:0045824)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
Synonyms: down regulation of innate immune response; down-regulation of innate immune response; downregulation of innate immune response; inhibition of innate immune response
obsolete negative regulation of intermediate filament polymerization and/or depolymerization (GO:0045825)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization.
Synonyms: negative regulation of intermediate filament polymerization and/or depolymerization
Comment: This term was made obsolete because it has been split.
obsolete positive regulation of intermediate filament polymerization and/or depolymerization (GO:0045826)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization.
Synonyms: positive regulation of intermediate filament polymerization and/or depolymerization
Comment: This term was made obsolete because it has been split.
negative regulation of isoprenoid metabolic process (GO:0045827)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
Synonyms: down regulation of isoprenoid metabolic process; down-regulation of isoprenoid metabolic process; downregulation of isoprenoid metabolic process; inhibition of isoprenoid metabolic process; negative regulation of isoprenoid metabolism
obsolete positive regulation of isoprenoid metabolic process (GO:0045828)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
Synonyms: activation of isoprenoid metabolic process; positive regulation of isoprenoid metabolism; stimulation of isoprenoid metabolic process; up regulation of isoprenoid metabolic process; up-regulation of isoprenoid metabolic process; upregulation of isoprenoid metabolic process
Comment: This term was obsoleted because it is an unnecessary grouping class.
negative regulation of isotype switching (GO:0045829)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
Synonyms: down regulation of isotype switching; down-regulation of isotype switching; downregulation of isotype switching; inhibition of isotype switching; negative regulation of class switch recombination; negative regulation of class switching; negative regulation of isotype switch recombination
obsolete negative regulation of light-activated channel activity (GO:0045831)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity.
Synonyms: down regulation of light-activated channel activity; down-regulation of light-activated channel activity; downregulation of light-activated channel activity; inhibition of light-activated channel activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete positive regulation of light-activated channel activity (GO:0045832)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of light-activated channel activity.
Synonyms: activation of light-activated channel activity; stimulation of light-activated channel activity; up regulation of light-activated channel activity; up-regulation of light-activated channel activity; upregulation of light-activated channel activity
Comment: This term was obsoleted because it represents a molecular function.
negative regulation of lipid metabolic process (GO:0045833)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.
Synonyms: down regulation of lipid metabolic process; down-regulation of lipid metabolic process; downregulation of lipid metabolic process; inhibition of lipid metabolic process; negative regulation of lipid metabolism
positive regulation of lipid metabolic process (GO:0045834)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.
Synonyms: activation of lipid metabolic process; positive regulation of lipid metabolism; stimulation of lipid metabolic process; up regulation of lipid metabolic process; up-regulation of lipid metabolic process; upregulation of lipid metabolic process
negative regulation of meiotic nuclear division (GO:0045835)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
Synonyms: down regulation of meiosis; down-regulation of meiosis; downregulation of meiosis; inhibition of meiosis; negative regulation of meiosis
positive regulation of meiotic nuclear division (GO:0045836)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of meiosis.
Synonyms: activation of meiosis; positive regulation of meiosis; stimulation of meiosis; up regulation of meiosis; up-regulation of meiosis; upregulation of meiosis
negative regulation of membrane potential (GO:0045837)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
Synonyms: down regulation of membrane potential; down-regulation of membrane potential; downregulation of membrane potential; inhibition of membrane potential; reduction of membrane potential
positive regulation of membrane potential (GO:0045838)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
Synonyms: activation of membrane potential; elevation of membrane potential; stimulation of membrane potential; up regulation of membrane potential; up-regulation of membrane potential; upregulation of membrane potential
positive regulation of mitotic nuclear division (GO:0045840)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mitosis.
Synonyms: activation of mitosis; mitogenic activity; positive regulation of mitosis; stimulation of mitosis; up regulation of mitosis; up-regulation of mitosis; upregulation of mitosis
negative regulation of mitotic metaphase/anaphase transition (GO:0045841)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms: down regulation of mitotic metaphase/anaphase transition; down-regulation of mitotic metaphase/anaphase transition; downregulation of mitotic metaphase/anaphase transition; inhibition of mitotic metaphase/anaphase transition
positive regulation of mitotic metaphase/anaphase transition (GO:0045842)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms: activation of mitotic metaphase/anaphase transition; stimulation of mitotic metaphase/anaphase transition; up regulation of mitotic metaphase/anaphase transition; up-regulation of mitotic metaphase/anaphase transition; upregulation of mitotic metaphase/anaphase transition
negative regulation of striated muscle tissue development (GO:0045843)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.
Synonyms: down regulation of striated muscle development; down-regulation of striated muscle development; downregulation of striated muscle development; inhibition of striated muscle development
positive regulation of striated muscle tissue development (GO:0045844)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of striated muscle development.
Synonyms: activation of striated muscle development; stimulation of striated muscle development; up regulation of striated muscle development; up-regulation of striated muscle development; upregulation of striated muscle development
negative regulation of nitrogen utilization (GO:0045847)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization.
Synonyms: down regulation of nitrogen utilization; down-regulation of nitrogen utilization; downregulation of nitrogen utilization; inhibition of nitrogen utilization
positive regulation of nitrogen utilization (GO:0045848)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of nitrogen utilization.
Synonyms: activation of nitrogen utilization; stimulation of nitrogen utilization; up regulation of nitrogen utilization; up-regulation of nitrogen utilization; upregulation of nitrogen utilization
negative regulation of nurse cell apoptotic process (GO:0045849)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process.
Synonyms: down regulation of nurse cell apoptosis; down-regulation of nurse cell apoptosis; downregulation of nurse cell apoptosis; inhibition of nurse cell apoptosis; negative regulation of nurse cell apoptosis
positive regulation of nurse cell apoptotic process (GO:0045850)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process.
Synonyms: activation of nurse cell apoptosis; positive regulation of nurse cell apoptosis; stimulation of nurse cell apoptosis; up regulation of nurse cell apoptosis; up-regulation of nurse cell apoptosis; upregulation of nurse cell apoptosis
pH reduction (GO:0045851)
Namespace: biological_process
Definition: Any process that reduces the internal pH of an organism, part of an organism or a cell, corresponding to an increase in hydrogen ion concentration.
Synonyms: acidification
pH elevation (GO:0045852)
Namespace: biological_process
Definition: Any process that increases the internal pH of an organism, part of an organism or a cell, corresponding to a decrease in hydrogen ion concentration.
negative regulation of bicoid mRNA localization (GO:0045853)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.
Synonyms: down regulation of bicoid mRNA localization; down-regulation of bicoid mRNA localization; downregulation of bicoid mRNA localization; inhibition of bicoid mRNA localization; negative regulation of bicoid mRNA localisation
positive regulation of bicoid mRNA localization (GO:0045854)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.
Synonyms: activation of bicoid mRNA localization; positive regulation of bicoid mRNA localisation; stimulation of bicoid mRNA localization; up regulation of bicoid mRNA localization; up-regulation of bicoid mRNA localization; upregulation of bicoid mRNA localization
negative regulation of pole plasm oskar mRNA localization (GO:0045855)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.
Synonyms: down regulation of pole plasm oskar mRNA localization; down-regulation of pole plasm oskar mRNA localization; downregulation of pole plasm oskar mRNA localization; inhibition of pole plasm oskar mRNA localization; negative regulation of oocyte pole plasm oskar mRNA localization; negative regulation of pole plasm oskar mRNA localisation
positive regulation of pole plasm oskar mRNA localization (GO:0045856)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.
Synonyms: activation of pole plasm oskar mRNA localization; positive regulation of oocyte pole plasm oskar mRNA localization; positive regulation of pole plasm oskar mRNA localisation; stimulation of pole plasm oskar mRNA localization; up regulation of pole plasm oskar mRNA localization; up-regulation of pole plasm oskar mRNA localization; upregulation of pole plasm oskar mRNA localization
obsolete positive regulation of molecular function, epigenetic (GO:0045858)
Namespace: biological_process
Definition: OBSOLETE. Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
Synonyms: activation of protein activity, epigenetic; positive regulation of protein activity, epigenetic; stimulation of protein activity, epigenetic; up regulation of protein activity, epigenetic; up-regulation of protein activity, epigenetic; upregulation of protein activity, epigenetic
Comment: This term was obsoleted because it is not an active process.
positive regulation of protein kinase activity (GO:0045860)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of protein kinase activity.
Synonyms: stimulation of protein kinase activity; up regulation of protein kinase activity; up-regulation of protein kinase activity; upregulation of protein kinase activity
negative regulation of proteolysis (GO:0045861)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
Synonyms: down regulation of proteolysis; down-regulation of proteolysis; downregulation of proteolysis; inhibition of proteolysis; negative regulation of peptidolysis
positive regulation of proteolysis (GO:0045862)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
Synonyms: activation of proteolysis; positive regulation of peptidolysis; stimulation of proteolysis; up regulation of proteolysis; up-regulation of proteolysis; upregulation of proteolysis
obsolete negative regulation of pteridine metabolic process (GO:0045863)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine.
Synonyms: down regulation of pteridine metabolic process; down-regulation of pteridine metabolic process; downregulation of pteridine metabolic process; inhibition of pteridine metabolic process; negative regulation of pteridine metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete positive regulation of pteridine metabolic process (GO:0045864)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine.
Synonyms: activation of pteridine metabolic process; positive regulation of pteridine metabolism; stimulation of pteridine metabolic process; up regulation of pteridine metabolic process; up-regulation of pteridine metabolic process; upregulation of pteridine metabolic process
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete regulation of recombination within rDNA repeats (GO:0045865)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.
Synonyms: regulation of recombination within rDNA repeats
Comment: This term was made obsolete because it describes a substrate-specific process.
obsolete positive regulation of recombination within rDNA repeats (GO:0045866)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.
Synonyms: positive regulation of recombination within rDNA repeats
Comment: This term was made obsolete because it describes a substrate-specific process.
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045870)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of retroviral genome replication.
Synonyms: activation of retroviral genome replication; positive regulation of retroviral genome replication; stimulation of retroviral genome replication; up regulation of retroviral genome replication; up-regulation of retroviral genome replication; upregulation of retroviral genome replication
obsolete positive regulation of rhodopsin gene expression (GO:0045872)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression.
Synonyms: activation of rhodopsin gene activity; positive regulation of rhodopsin gene activity; stimulation of rhodopsin gene activity; up regulation of rhodopsin gene activity; up-regulation of rhodopsin gene activity; upregulation of rhodopsin gene activity
Comment: This term was obsoleted because it refers to a specific gene product. The gene product should be captured as an annotation extension using 'has input'.
negative regulation of sevenless signaling pathway (GO:0045873)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway.
Synonyms: down regulation of sevenless signaling pathway; down-regulation of sevenless signaling pathway; downregulation of sevenless signaling pathway; inhibition of sevenless signaling pathway; negative regulation of sev signaling pathway; negative regulation of sevenless signalling pathway