LiteFold/GO huggingface dataset:
positive regulation of vulval development (GO:0040026)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
Synonyms: activation of vulval development; stimulation of vulval development; up regulation of vulval development; up-regulation of vulval development; upregulation of vulval development
regulation of vulval development (GO:0040028)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
obsolete regulation of molecular function, epigenetic (GO:0040030)
Namespace: biological_process
Definition: OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
Synonyms: regulation of protein activity, epigenetic
Comment: This term was obsoleted because it is not an active process.
snRNA modification (GO:0040031)
Namespace: biological_process
Definition: The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA.
post-embryonic body morphogenesis (GO:0040032)
Namespace: biological_process
Definition: The process in which the anatomical structures of the post-embryonic soma are generated and organized.
Comment: Note that this term was 'body morphogenesis (sensu Nematoda)'.
sRNA-mediated post-transcriptional gene silencing (GO:0040033)
Namespace: biological_process
Definition: A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria.
Synonyms: downregulation of mRNA translation, ncRNA-mediated; inhibition of mRNA translation, ncRNA-mediated; RNA-mediated gene silencing by inhibition of translation; small RNA-mediated gene silencing; sRNA-mediated gene silencing
Comment: It is postulated that there 3 mechanisms of sRNA-mediated gene silencing: (i) translation inhibition, (ii) RNA destabilization, and (iii) transcription termination loop formation (as this is common when looking at riboswitches). sRNA mediated gene silencing is sometimes referred to as 'regulation of riboswitch'.
regulation of development, heterochronic (GO:0040034)
Namespace: biological_process
Definition: Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
Synonyms: developmental timing; heterochronic regulation of development; temporal regulation of development
obsolete hermaphrodite genitalia development (GO:0040035)
Namespace: biological_process
Definition: OBSOLETE. The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures.
Comment: The reason for obsoletion is that this term maybe redundant with female genitalia development.
regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
Synonyms: regulation of FGF receptor signaling pathway; regulation of FGF receptor signalling pathway; regulation of FGFR signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
Synonyms: down regulation of fibroblast growth factor receptor signaling pathway; down-regulation of fibroblast growth factor receptor signaling pathway; downregulation of fibroblast growth factor receptor signaling pathway; inhibition of fibroblast growth factor receptor signaling pathway; negative regulation of FGF receptor signaling pathway; negative regulation of FGF receptor signalling pathway; negative regulation of FGFR signaling pathway
inductive cell migration (GO:0040039)
Namespace: biological_process
Definition: Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans.
thermosensory behavior (GO:0040040)
Namespace: biological_process
Definition: Behavior that is dependent upon the sensation of temperature.
Synonyms: behavioral response to temperature stimulus; behavioural response to temperature stimulus; thermosensory behaviour
translocation of peptides or proteins into host (GO:0042000)
Namespace: biological_process
Definition: The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: translocation of peptides or proteins into other organism during symbiotic interaction; translocation of peptides or proteins into other organism involved in symbiotic interaction; transport of peptides or proteins into host; transport of peptides or proteins into other organism during symbiotic interaction
hermaphrodite somatic sex determination (GO:0042001)
Namespace: biological_process
Definition: The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans.
masculinization of hermaphrodite soma (GO:0042003)
Namespace: biological_process
Definition: Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans.
feminization of hermaphrodite soma (GO:0042004)
Namespace: biological_process
Definition: Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans.
masculinization of hermaphroditic germ-line (GO:0042006)
Namespace: biological_process
Definition: The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans.
interleukin-18 binding (GO:0042007)
Namespace: molecular_function
Definition: Binding to interleukin-18.
Synonyms: IL-18 binding
interleukin-18 receptor activity (GO:0042008)
Namespace: molecular_function
Definition: Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-18 receptor activity; IL-18R
interleukin-15 binding (GO:0042009)
Namespace: molecular_function
Definition: Binding to interleukin-15.
Synonyms: IL-15 binding
interleukin-15 receptor activity (GO:0042010)
Namespace: molecular_function
Definition: Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-15 receptor activity; IL-15R
interleukin-16 binding (GO:0042011)
Namespace: molecular_function
Definition: Binding to interleukin-16.
Synonyms: IL-16 binding
interleukin-16 receptor activity (GO:0042012)
Namespace: molecular_function
Definition: Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-16 receptor activity; IL-16R
interleukin-19 binding (GO:0042013)
Namespace: molecular_function
Definition: Binding to interleukin-19.
Synonyms: IL-19 binding
interleukin-19 receptor activity (GO:0042014)
Namespace: molecular_function
Definition: Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-19 receptor activity; IL-19R
interleukin-20 binding (GO:0042015)
Namespace: molecular_function
Definition: Binding to interleukin-20.
Synonyms: IL-20 binding
interleukin-22 binding (GO:0042017)
Namespace: molecular_function
Definition: Binding to interleukin-22.
Synonyms: IL-22 binding
interleukin-22 receptor activity (GO:0042018)
Namespace: molecular_function
Definition: Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-22 receptor activity; IL-22R
interleukin-23 binding (GO:0042019)
Namespace: molecular_function
Definition: Binding to interleukin-23.
Synonyms: IL-23 binding
interleukin-23 receptor activity (GO:0042020)
Namespace: molecular_function
Definition: Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-23 receptor activity; IL-23R
granulocyte macrophage colony-stimulating factor complex binding (GO:0042021)
Namespace: molecular_function
Definition: Binding to a granulocyte macrophage colony-stimulating factor complex.
Synonyms: GM-CSF complex binding; GMC-SF complex binding; granulocyte macrophage colony stimulating factor complex binding
interleukin-12 receptor complex (GO:0042022)
Namespace: cellular_component
Definition: A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.
Synonyms: IL-12 receptor complex; IL12RB1-IL12RB2 complex
host cell nucleus (GO:0042025)
Namespace: cellular_component
Definition: A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
protein refolding (GO:0042026)
Namespace: biological_process
Definition: The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
Synonyms: heat shock protein activity
obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity (GO:0042027)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0).
Synonyms: cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
Comment: This term was made obsolete because it is contains gene product specific characteristics.
ATPase inhibitor activity (GO:0042030)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces an ATP hydrolysis activity.
Synonyms: adenosinetriphosphatase inhibitor
obsolete angiotensin-converting enzyme inhibitor activity (GO:0042031)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I.
Synonyms: ACE inhibitor; angiotensin-converting enzyme inhibitor activity; peptidyl dipeptidase A inhibitor
Comment: This term was made obsolete because it represents a regulator of a non-existent molecular function term.
obsolete peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine (GO:0042034)
Namespace: biological_process
Definition: OBSOLETE. The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester.
Synonyms: peptidyl-lysine esterification
Comment: This term was obsoleted because it represents a molecular function.
obsolete peptidyl-histidine methylation, to form pros-methylhistidine (GO:0042037)
Namespace: biological_process
Definition: OBSOLETE. The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).
Synonyms: peptidyl-histidine pros-methylation
Comment: This term was obsoleted because it represents a molecular function.
peptidyl-histidine methylation, to form tele-methylhistidine (GO:0042038)
Namespace: biological_process
Definition: The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).
Synonyms: peptidyl-histidine tele-methylation
obsolete vanadium incorporation into metallo-sulfur cluster (GO:0042039)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n).
Synonyms: vanadium incorporation into metallo-sulphur cluster
Comment: This term was obsoleted because it represents a molecular function.
metal incorporation into metallo-molybdopterin complex (GO:0042040)
Namespace: biological_process
Definition: The incorporation of a metal into a metallo-molybdopterin complex.
tungsten incorporation into tungsten-molybdopterin complex (GO:0042042)
Namespace: biological_process
Definition: The incorporation of tungsten into a tungsten-molybdopterin complex.
neurexin family protein binding (GO:0042043)
Namespace: molecular_function
Definition: Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.
Synonyms: neuroligin
epithelial fluid transport (GO:0042045)
Namespace: biological_process
Definition: The directed movement of fluid across epithelia.
obsolete W-molybdopterin cofactor metabolic process (GO:0042046)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.
Synonyms: Moco metabolic process; Moco metabolism; W-molybdopterin cofactor metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
W-molybdopterin cofactor biosynthetic process (GO:0042047)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.
Synonyms: Moco biosynthesis; Moco biosynthetic process; W-molybdopterin cofactor anabolism; W-molybdopterin cofactor biosynthesis; W-molybdopterin cofactor formation; W-molybdopterin cofactor synthesis
olfactory behavior (GO:0042048)
Namespace: biological_process
Definition: The behavior of an organism in response to an odor.
Synonyms: behavioral response to scent; behavioral response to smell; behavioural response to odour; behavioural response to scent; behavioural response to smell; olfactory behaviour
intracellular acyl-CoA homeostasis (GO:0042049)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of acyl-CoA within a cell.
Synonyms: cell acyl-CoA homeostasis; cellular acyl-CoA homeostasis
compound eye photoreceptor development (GO:0042051)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.
Synonyms: adult eye photoreceptor development
rhabdomere development (GO:0042052)
Namespace: biological_process
Definition: The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
Synonyms: rhabdomere organization
regulation of dopamine metabolic process (GO:0042053)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
Synonyms: regulation of dopamine metabolism
histone methyltransferase activity (GO:0042054)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue.
Synonyms: histone methylase activity; histone N-methyltransferase activity
chemoattractant activity (GO:0042056)
Namespace: molecular_function
Definition: Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
Synonyms: attractant
obsolete transforming growth factor beta receptor anchoring activity (GO:0042057)
Namespace: molecular_function
Definition: OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location.
Synonyms: TGF-beta receptor anchoring activity; TGFbeta receptor anchoring activity; transforming growth factor beta receptor anchor activity; transforming growth factor beta receptor anchoring activity
Comment: This term was made obsolete because it represents a combination of process and function information.
regulation of epidermal growth factor receptor signaling pathway (GO:0042058)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms: regulation of EGF receptor signaling pathway; regulation of EGF receptor signalling pathway; regulation of EGFR signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms: down regulation of epidermal growth factor receptor signaling pathway; down-regulation of epidermal growth factor receptor signaling pathway; downregulation of epidermal growth factor receptor signaling pathway; inhibition of epidermal growth factor receptor signaling pathway; negative regulation of EGF receptor signaling pathway; negative regulation of EGF receptor signalling pathway; negative regulation of EGFR signaling pathway
wound healing (GO:0042060)
Namespace: biological_process
Definition: The series of events that restore integrity to a damaged tissue, following an injury.
gliogenesis (GO:0042063)
Namespace: biological_process
Definition: The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
Synonyms: glial cell generation
obsolete cell adhesion receptor regulator activity (GO:0042064)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: cell adhesion receptor regulator activity
Comment: This term was made obsolete because it represents a gene product.
glial cell growth (GO:0042065)
Namespace: biological_process
Definition: Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
perineurial glial growth (GO:0042066)
Namespace: biological_process
Definition: Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons.
establishment of ommatidial planar polarity (GO:0042067)
Namespace: biological_process
Definition: The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.
Synonyms: establishment of ommatidial polarity
regulation of catecholamine metabolic process (GO:0042069)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.
Synonyms: regulation of catecholamine metabolism
leucokinin receptor activity (GO:0042071)
Namespace: molecular_function
Definition: Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity.
intraciliary transport (GO:0042073)
Namespace: biological_process
Definition: The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
Synonyms: IFT; intraflagellar transport; intraflagellar transport involved in cilium organization; intraflagellar transport involved in microtubule-based flagellum organisation
Comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
cell migration involved in gastrulation (GO:0042074)
Namespace: biological_process
Definition: The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
obsolete nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide (GO:0042075)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase.
Synonyms: nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide
Comment: This term was obsoleted because it represents a molecular function.
protein phosphate-linked glycosylation (GO:0042076)
Namespace: biological_process
Definition: The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues.
Synonyms: phosphoglycosylation; protein amino acid phosphate-linked glycosylation
obsolete protein phosphate-linked glycosylation via serine (GO:0042077)
Namespace: biological_process
Definition: OBSOLETE. The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues.
Synonyms: protein amino acid phosphate-linked glycosylation via serine
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete GPI/GSI anchor metabolic process (GO:0042079)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: GPI/GSI anchor metabolic process
Comment: This term was made obsolete because it is a composite term that represents two individual processes.
obsolete GSI anchor metabolic process (GO:0042081)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane.
Synonyms: GPI/GSI anchor metabolic process; GPI/GSI anchor metabolism; GSI anchor metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.