LiteFold/GO huggingface dataset:
obsolete suppression by virus of host interferon receptor activity (GO:0039511)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor.
Synonyms: down-regulation by virus of host interferon receptor activity; downregulation by virus of host interferon receptor activity; inhibition by virus of host interferon receptor activity; inhibition of host interferon receptors by virus; negative regulation by virus of host interferon receptor activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete suppression by virus of host protein tyrosine kinase activity (GO:0039512)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity.
Synonyms: down-regulation by virus of host protein tyrosine kinase activity; downregulation by virus of host protein tyrosine kinase activity; inhibition by virus of host protein tyrosine kinase activity; negative regulation by virus of host protein tyrosine kinase activity
Comment: This term was obsoleted because it is a molecular function represented as a biological process.
obsolete suppression by virus of host catalytic activity (GO:0039513)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity.
Synonyms: down-regulation by virus of host enzyme activity; downregulation by virus of host catalytic activity; inhibition by virus of host catalytic activity; negative regulation by virus of host catalytic activity
Comment: This term was obsoleted because it represents a molecular function.
symbiont-mediated suppression of host JAK-STAT cascade (GO:0039514)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption by virus of host JAK-STAT cascade; down-regulation by virus of host JAK-STAT cascade; downregulation by virus of host JAK-STAT cascade; inhibition by virus of host JAK-STAT cascade; negative regulation by virus of host JAK-STAT cascade; suppression by virus of host JAK-STAT cascade
obsolete modulation by virus of host catalytic activity (GO:0039516)
Namespace: biological_process
Definition: OBSOLETE. The process in which a virus effects a change in host enzyme activity.
Synonyms: modulation of catalytic activity of host by virus; regulation by virus of host catalytic activity; regulation of host catalytic activity by virus
Comment: This term was obsoleted because it represents a molecular function.
obsolete modulation by virus of host protein serine/threonine phosphatase activity (GO:0039517)
Namespace: biological_process
Definition: OBSOLETE. The process in which a virus effects a change in host protein serine/threonine phosphatase activity.
Synonyms: modulation by virus of protein serine/threonine phosphatase activity in host; regulation by virus of host protein serine/threonine phosphatase activity
Comment: This term was obsoleted because it is a molecular function represented as a biological process.
obsolete suppression by virus of host cytokine activity (GO:0039518)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity.
Synonyms: down-regulation by virus of host cytokine activity; downregulation by virus of host cytokine activity; inhibition by virus of host cytokine activity; negative regulation by virus of host cytokine activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete modulation by virus of host autophagy (GO:0039519)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host.
Synonyms: regulation by virus of host autophagy
Comment: This term was osboleted because it represents the same process as symbiont-mediated perturbation of host autophagy ; GO:0075071.
obsolete suppression by virus of host autophagy (GO:0039521)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host.
Synonyms: inhibition by virus of host autophagy; negative regulation by virus of host autophagy
Comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host autophagy ; GO:0140321.
symbiont-mediated suppression of host mRNA export from nucleus (GO:0039522)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: inhibition by virus of host mRNA nuclear export; inhibition of host mRNA nuclear export by virus; negative regulation by virus of host mRNA nuclear export; suppression by virus of host mRNA export from nucleus; suppression of host mRNA nuclear export by virus
symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity (GO:0039523)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the transcription of genes into mRNA in its host by directly inhibiting host RNA polymerase II activity. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: inhibition of host RNA polymerase II activity by virus; inhibition of host RNA polymerase II by virus; negative regulation by virus of host RNA polymerase II activity; suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; suppression by virus of host RNA polymerase II activity
symbiont-mediated perturbation of host chromatin organization (GO:0039525)
Namespace: biological_process
Definition: A process in which a symbiont alters or subverts the organization of chromatin in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: modulation by virus of host chromatin organisation; modulation by virus of host chromatin organization; modulation of host chromatin by virus; modulation of host chromatin structure by virus; regulation by virus of host chromatin organization
obsolete perturbation by virus of host apoptosis (GO:0039526)
Namespace: biological_process
Definition: OBSOLETE. A process in which a viral gene product affects host apoptosis, leading to a change in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: modulation by virus of host apoptosis; modulation by virus of host apoptotic process; modulation of host cell apoptosis by virus; perturbation by virus of host apoptotic process; regulation by virus of host apoptosis
Comment: This term has been obsoleted because it is too specific, consider symbiont-mediated perturbation of host apoptosis ; GO:0052150.
symbiont-mediated suppression of host TRAF-mediated signal transduction (GO:0039527)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption by virus of host TRAF-mediated signal transduction; inhibition of host TRAF-mediated signal transduction by virus; inhibition of host TRAFs by virus; negative regulation by virus of host TRAF-mediated signal transduction; suppression by virus of host TRAF activity; suppression by virus of host TRAF-mediated signal transduction; suppression by virus of host tumor necrosis factor receptor-associated factor signaling
RIG-I signaling pathway (GO:0039529)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.
Synonyms: DDX58 signaling pathway; retinoic acid inducible gene I signaling pathway; RIG-I signalling pathway; RIG-I-like receptor (RLR) signaling pathway; RIG-like helicase signaling pathway; RIG-like receptor signaling pathway; RLH signaling pathway; RLR signaling pathway
MDA-5 signaling pathway (GO:0039530)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.
Synonyms: IFIH1 signaling pathway; MDA-5 signalling pathway; MDA5 signaling pathway; melanoma differentiation-associated gene 5 signaling pathway
regulation of cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway.
Synonyms: regulation of cytosolic pattern recognition receptor signaling pathway; regulation of MAV signaling; regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway
negative regulation of cytoplasmic pattern recognition receptor signaling pathway (GO:0039532)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway.
Synonyms: negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus; negative regulation of cytosolic pattern recognition receptor signaling pathway; negative regulation of MAVS signaling; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway
negative regulation of MDA-5 signaling pathway (GO:0039534)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the series of the MDA-5 signaling pathway.
Synonyms: negative regulation of IFIH1 signaling pathway; negative regulation of MDA-5 signalling pathway; negative regulation of MDA5 signaling pathway; negative regulation of melanoma differentiation-associated gene 5 signaling pathway
regulation of RIG-I signaling pathway (GO:0039535)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the RIG-I signaling pathway.
Synonyms: regulation of DDX58 signaling pathway; regulation of retinoic acid inducible gene I signaling pathway; regulation of RIG-I signalling pathway
symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway (GO:0039537)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response.
Synonyms: suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus; suppression by virus of host RIG-I-like receptor (RLR) signaling pathway; suppression by virus of host RIG-I/MDA5 signaling pathway; suppression by virus of host RIG-like helicase signaling pathway; suppression by virus of host RIG-like receptor signaling pathway; suppression by virus of host RLR signaling pathway; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway
Comment: Note that this term should be used when the symbiont directly inhibits a component of a host cytoplasmic receptor signaling pathway. In cases where the symbiont modifies its own molecules (proteins, DNA, RNA, lipids) to avoid recognition by the host, consider annotating to evasion of symbiont recognition by host pattern recognition receptor ; GO:0141141.
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity (GO:0039540)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
Synonyms: inhibition by virus of host DDX58 activity; inhibition by virus of host RIG-I; inhibition by virus of host RIG-I signaling; inhibition of host DDX58/RIG-I by virus; suppression by virus of host DDX58 signaling pathway; suppression by virus of host RIG-I activity; suppression by virus of host RIG-I signaling pathway; suppression by virus of host RIG-I signalling pathway; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity; symbiont-mediated suppression of host RIG-I signaling pathway
Comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response initiated by host RIG-I, either by binding and inhibiting host RIG-I directly, or by interfering with other processes so that RIG-I is unable to carry out its normal function (e.g. by processing viral RNA so it cannot be recognized by RIG-I, or by promoting the degradation of RIG-I).
obsolete suppression by virus of host RIG-I via RIG-I binding (GO:0039541)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by binding to RIG-I itself.
Synonyms: inhibition by virus of host DDX58:MAVS binding
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host RIG-I K63-linked ubiquitination (GO:0039542)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity.
Synonyms: inhibition by virus of host DDX58 K63-linked ubiquitination; inhibition by virus of host RIG-I activity by inhibition of RIG-I ubiquitination; inhibition by virus of TRIM25-mediated ubiquitination of host RIG-I
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host RIG-I activity by RIG-I proteolysis (GO:0039544)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction.
Synonyms: cleavage of RIG-I by viral proteinase; inhibition by virus of host RIG-I activity by RIG-I proteolysis
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity (GO:0039545)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses.
Synonyms: inhibition of host MAVS by virus; suppression by virus of host MAVS activity; suppression by virus of host mitochondrial antiviral-signaling protein; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
Comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity (GO:0039548)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.
Synonyms: inhibition of host IRF3 by virus; inhibition of IRF3-dependent antiviral response; suppression by virus of host interferon regulatory factor 3; suppression by virus of host IRF3 activity; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
obsolete suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation (GO:0039549)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes.
Synonyms: inhibition of phosphorylation-induced activation of host IRF3; inhibition of virus-induced IRF-3 phosphorylation
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host IRF3 activity by inhibition of DNA binding (GO:0039550)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites.
Synonyms: inhibition by virus of host IRF3-DNA binding
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
obsolete suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process (GO:0039551)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome.
Synonyms: promotion by virus of proteosome-dependent IRF3 degradation
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
RIG-I binding (GO:0039552)
Namespace: molecular_function
Definition: Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.
Synonyms: DDX58 binding; DDX58/RIG-I binding
obsolete suppression by virus of host chemokine activity (GO:0039553)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity.
Synonyms: down-regulation by virus of host chemokine activity; downregulation by virus of host chemokine activity; inhibition by virus of host chemokine activity; inhibition of host chemokines by virus; negative regulation by virus of host chemokine activity
Comment: This term was obsoleted because it represents a molecular function.
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity (GO:0039554)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
Synonyms: inhibition by virus of host MDA-5 signaling; inhibition of host IFIH1/MDA5 by virus; Inhibition of host MDA5 by virus; suppression by virus of host IFIH1 signaling pathway; suppression by virus of host MDA-5 activity; suppression by virus of host MDA-5 signaling pathway; suppression by virus of host MDA-5 signalling pathway; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity
obsolete suppression by virus of host MDA-5 activity via MDA-5 binding (GO:0039555)
Namespace: biological_process
Definition: OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by binding to MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector.
Synonyms: suppression by virus of host MDA5 activity by MDA-5 binding
Comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately.
MDA-5 binding (GO:0039556)
Namespace: molecular_function
Definition: Binding to MDA-5, a cytoplasmic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.
Synonyms: MDA5 binding
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity (GO:0039557)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.
Synonyms: inhibition of host interferon regulatory factor-7 by virus; inhibition of host IRF7 by virus; suppression by virus of host interferon regulatory factor 7 activity; suppression by virus of host IRF7 activity; suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
Comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.