LiteFold/GO huggingface dataset:
coenzyme A transmembrane transport (GO:0035349)
Namespace: biological_process
Definition: The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
Synonyms: coenzyme A membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
FAD transmembrane transport (GO:0035350)
Namespace: biological_process
Definition: The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form.
Synonyms: FAD membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
heme transmembrane transport (GO:0035351)
Namespace: biological_process
Definition: The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
Synonyms: heme membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
NAD transmembrane transport (GO:0035352)
Namespace: biological_process
Definition: The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH.
Synonyms: NAD membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
nicotinamide mononucleotide transmembrane transport (GO:0035353)
Namespace: biological_process
Definition: The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP.
Synonyms: nicotinamide mononucleotide membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
Toll-like receptor 1-Toll-like receptor 2 protein complex (GO:0035354)
Namespace: cellular_component
Definition: A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).
Synonyms: TLR1-TLR2 protein complex; TLR1:TLR2 complex; TLR2:TLR1 heterodimer; toll-like receptor TLR1:TLR2 heterodimeric complex
Toll-like receptor 2-Toll-like receptor 6 protein complex (GO:0035355)
Namespace: cellular_component
Definition: A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).
Synonyms: TLR2-TLR6 protein complex; TLR2:TLR6 heterodimer; TLR6:TLR2 complex; toll-like receptor TLR6:TLR2 heterodimeric complex
intracellular triglyceride homeostasis (GO:0035356)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell.
Synonyms: cellular triglyceride homeostasis
regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
Synonyms: regulation of peroxisome proliferator activated receptor signalling pathway; regulation of peroxisome proliferator-activated receptor signaling pathway; regulation of PPAR signaling pathway
negative regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035359)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
Synonyms: negative regulation of peroxisome proliferator activated receptor signalling pathway; negative regulation of peroxisome proliferator-activated receptor signaling pathway; negative regulation of PPAR signaling pathway
positive regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035360)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.
Synonyms: positive regulation of peroxisome proliferator activated receptor signalling pathway; positive regulation of peroxisome proliferator-activated receptor signaling pathway; positive regulation of PPAR signaling pathway
Cul8-RING ubiquitin ligase complex (GO:0035361)
Namespace: cellular_component
Definition: A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins.
protein-DNA ISRE complex assembly (GO:0035362)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA.
Synonyms: protein-DNA interferon-stimulated response element complex assembly
histone locus body (GO:0035363)
Namespace: cellular_component
Definition: A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.
Synonyms: HLB
regulation of thymine transport (GO:0035365)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: regulation of 5-methyluracil transport
negative regulation of thymine transport (GO:0035366)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: negative regulation of 5-methyluracil transport
positive regulation of thymine transport (GO:0035367)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: positive regulation of 5-methyluracil transport
pre-B cell receptor complex (GO:0035369)
Namespace: cellular_component
Definition: An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
Synonyms: pre-BCR
Comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
microtubule plus-end (GO:0035371)
Namespace: cellular_component
Definition: The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.
Synonyms: growing microtubule plus end; microtubule plus end
protein localization to microtubule (GO:0035372)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained at, a microtubule.
Synonyms: protein localisation to microtubule
chondroitin sulfate proteoglycan binding (GO:0035373)
Namespace: molecular_function
Definition: Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.
chondroitin sulfate binding (GO:0035374)
Namespace: molecular_function
Definition: Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).
zymogen binding (GO:0035375)
Namespace: molecular_function
Definition: Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
Synonyms: proenzyme binding
sterol import (GO:0035376)
Namespace: biological_process
Definition: The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Synonyms: sterol influx; sterol uptake
transepithelial water transport (GO:0035377)
Namespace: biological_process
Definition: The directed movement of water (H2O) from one side of an epithelium to the other.
carbon dioxide transmembrane transport (GO:0035378)
Namespace: biological_process
Definition: The process in which carbon dioxide (CO2) is transported across a membrane.
Synonyms: carbon dioxide membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
carbon dioxide transmembrane transporter activity (GO:0035379)
Namespace: molecular_function
Definition: Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other.
very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity (GO:0035380)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
Synonyms: very long-chain-3-hydroxyacyl-CoA dehydrogenase activity; very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
sterol transmembrane transport (GO:0035382)
Namespace: biological_process
Definition: The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Synonyms: sterol membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
obsolete thioester metabolic process (GO:0035383)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.
Synonyms: thioester metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete thioester biosynthetic process (GO:0035384)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.
Synonyms: thioester anabolism; thioester biosynthesis; thioester formation; thioester synthesis
Comment: This term was obsoleted because it is an unnecessary grouping term.
Roundabout signaling pathway (GO:0035385)
Namespace: biological_process
Definition: The series of molecular signals initiated by a SLIT protein binding to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: ROBO signaling pathway; ROBO/SLIT signaling pathway; Roundabout signalling pathway
regulation of Roundabout signaling pathway (GO:0035386)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway.
Synonyms: regulation of Roundabout signalling pathway
negative regulation of Roundabout signaling pathway (GO:0035387)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway.
Synonyms: negative regulation of Roundabout signalling pathway
obsolete maintenance of chromatin silencing at silent mating-type cassette (GO:0035391)
Namespace: biological_process
Definition: OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci.
Comment: This term was obsoleted because it represents a phenotype.
obsolete maintenance of chromatin silencing at telomere (GO:0035392)
Namespace: biological_process
Definition: OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere.
Comment: This term was obsoleted because it represented a phenotype.
chemokine (C-X-C motif) ligand 9 production (GO:0035393)
Namespace: biological_process
Definition: The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: CXCL9 production; MIG production; Monokine induced by gamma interferon production
regulation of chemokine (C-X-C motif) ligand 9 production (GO:0035394)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.
Synonyms: regulation of CXCL9 production; regulation of MIG production
negative regulation of chemokine (C-X-C motif) ligand 9 production (GO:0035395)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.
Synonyms: negative regulation of CXCL9 production; negative regulation of MIG production
positive regulation of chemokine (C-X-C motif) ligand 9 production (GO:0035396)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.
Synonyms: positive regulation of CXCL9 production; positive regulation of MIG production
helper T cell enhancement of adaptive immune response (GO:0035397)
Namespace: biological_process
Definition: Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.
Synonyms: provision of T cell help
helper T cell enhancement of T cell mediated immune response (GO:0035398)
Namespace: biological_process
Definition: Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell.
Synonyms: helper T cell enhancement of T cell mediated immunity; provision of T cell help to T cell
helper T cell enhancement of B cell mediated immune response (GO:0035399)
Namespace: biological_process
Definition: Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell.
Synonyms: helper T cell enhancement of B cell mediated immunity; provision of T cell help to B cell
obsolete histone tyrosine kinase activity (GO:0035400)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone.
Synonyms: histone-tyrosine kinase activity
Comment: This term was obsoleted because it represents an unnecessary grouping class.
histone H3Y41 kinase activity (GO:0035401)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3.
Synonyms: histone H3-Y41 kinase activity; histone kinase activity (H3-Y41 specific); histone tyrosine kinase activity (H3-Y41 specific); histone-tyrosine kinase activity (H3-Y41 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3T11 kinase activity (GO:0035402)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3.
Synonyms: histone H3-T11 kinase activity; histone kinase activity (H3-T11 specific); histone threonine kinase activity (H3-T11 specific); histone-threonine kinase activity (H3-T11 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3T6 kinase activity (GO:0035403)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3.
Synonyms: histone H3-T6 kinase activity; histone kinase activity (H3-T6 specific); histone threonine kinase activity (H3-T6 specific); histone-threonine kinase activity (H3-T6 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
obsolete histone-serine phosphorylation (GO:0035404)
Namespace: biological_process
Definition: OBSOLETE. The modification of histones by addition of a phosphate group to a serine residue.
Synonyms: histone serine phosphorylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone-threonine phosphorylation (GO:0035405)
Namespace: biological_process
Definition: OBSOLETE. The modification of histones by addition of a phosphate group to a threonine residue.
Synonyms: histone threonine phosphorylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone-tyrosine phosphorylation (GO:0035406)
Namespace: biological_process
Definition: OBSOLETE. The modification of histones by addition of a phosphate group to a tyrosine residue.
Synonyms: histone tyrosine phosphorylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-T11 phosphorylation (GO:0035407)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-T6 phosphorylation (GO:0035408)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-Y41 phosphorylation (GO:0035409)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
obsolete dihydrotestosterone 17-beta-dehydrogenase activity (GO:0035410)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH.
Comment: This term was obsoleted because it represents a specific substrate of testosterone dehydrogenase [NAD(P)+] activity ; GO:0030283.
obsolete regulation of mitotic prometaphase (GO:0035415)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region.
Synonyms: regulation of mitotic prometaphase
Comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
obsolete positive regulation of mitotic prometaphase (GO:0035416)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region.
Synonyms: positive regulation of mitotic prometaphase
Comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
obsolete negative regulation of mitotic prometaphase (GO:0035417)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region.
Synonyms: negative regulation of mitotic prometaphase
Comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated.
protein localization to synapse (GO:0035418)
Namespace: biological_process
Definition: Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
Synonyms: protein localisation to synapse
obsolete activation of MAPK activity involved in innate immune response (GO:0035419)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
Comment: This term was obsoleted because it should be represented as a GO-CAM model.
obsolete MAPK cascade involved in innate immune response (GO:0035420)
Namespace: biological_process
Definition: OBSOLETE. A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
Synonyms: MAPKKK cascade involved in innate immune response
Comment: This term was obsoleted because it represents a GO-CAM model.