LiteFold/GO huggingface dataset:
cell adhesion receptor activity (GO:0004895)
Namespace: molecular_function
Definition: The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins.
Comment: Reinstated term from obsolete.
cytokine receptor activity (GO:0004896)
Namespace: molecular_function
Definition: Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; IL receptor; interleukin receptor activity
obsolete gp130 (GO:0004898)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: gp130
Comment: This term was made obsolete because it represents a gene product.
erythropoietin receptor activity (GO:0004900)
Namespace: molecular_function
Definition: Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
granulocyte macrophage colony-stimulating factor receptor activity (GO:0004901)
Namespace: molecular_function
Definition: Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: CSF-2 receptor activity; CSF2R; GM-CSF receptor activity; GMC-SF receptor activity; granulocyte macrophage colony stimulating factor receptor activity
granulocyte colony-stimulating factor receptor activity (GO:0004902)
Namespace: molecular_function
Definition: Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: CSF3R; G-CSF receptor activity; granulocyte colony stimulating factor receptor activity
growth hormone receptor activity (GO:0004903)
Namespace: molecular_function
Definition: Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
interferon receptor activity (GO:0004904)
Namespace: molecular_function
Definition: Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IFN receptor activity
type I interferon receptor activity (GO:0004905)
Namespace: molecular_function
Definition: Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
Synonyms: interferon-alpha receptor activity; interferon-alpha/beta receptor activity; interferon-beta receptor activity; interferon-delta receptor activity; interferon-epsilon receptor activity; interferon-kappa receptor activity; interferon-omega receptor activity; interferon-tau receptor activity; interferon-zeta receptor activity; type I IFN receptor activity
type II interferon receptor activity (GO:0004906)
Namespace: molecular_function
Definition: Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IFN-gamma receptor activity; IFNG receptor activity; interferon-gamma receptor activity
interleukin-1 receptor activity (GO:0004908)
Namespace: molecular_function
Definition: Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
Synonyms: IL-1 receptor activity; IL-1R
interleukin-1, type I, activating receptor activity (GO:0004909)
Namespace: molecular_function
Definition: Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.
Synonyms: IL-1 type I, activating binding; IL-1 type I, activating receptor; interleukin-1 activating receptor activity; interleukin-1 type I receptor activity; interleukin-1, type I, activating binding
interleukin-1, type II, blocking receptor activity (GO:0004910)
Namespace: molecular_function
Definition: Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors.
Synonyms: IL-1 type II, blocking binding; IL-1 type II, blocking receptor; interleukin-1 blocking receptor activity; interleukin-1 type II receptor activity; interleukin-1, type II, blocking binding
interleukin-3 receptor activity (GO:0004912)
Namespace: molecular_function
Definition: Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-3 receptor activity; IL-3R
interleukin-4 receptor activity (GO:0004913)
Namespace: molecular_function
Definition: Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-4 receptor activity; IL-4R
interleukin-6 receptor activity (GO:0004915)
Namespace: molecular_function
Definition: Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: gp130; IL-6 receptor activity; IL-6R
interleukin-7 receptor activity (GO:0004917)
Namespace: molecular_function
Definition: Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-7 receptor activity; IL-7R
interleukin-8 receptor activity (GO:0004918)
Namespace: molecular_function
Definition: Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-8 receptor activity; IL-8R
interleukin-9 receptor activity (GO:0004919)
Namespace: molecular_function
Definition: Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-9 receptor activity; IL-9R
interleukin-10 receptor activity (GO:0004920)
Namespace: molecular_function
Definition: Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-10 receptor activity; IL-10R
interleukin-11 receptor activity (GO:0004921)
Namespace: molecular_function
Definition: Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: gp130; IL-11 receptor activity; IL-11R
leukemia inhibitory factor receptor activity (GO:0004923)
Namespace: molecular_function
Definition: Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: leukemia inhibitory factor receptor beta-protein activity; LIF receptor activity
oncostatin-M receptor activity (GO:0004924)
Namespace: molecular_function
Definition: Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
prolactin receptor activity (GO:0004925)
Namespace: molecular_function
Definition: Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
obsolete sevenless receptor activity (GO:0004927)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: sevenless receptor activity
Comment: This term was made obsolete because it represents a gene product rather than an activity.
obsolete frizzled receptor activity (GO:0004928)
Namespace: molecular_function
Definition: OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity.
Synonyms: frizzled receptor activity
Comment: This term was made obsolete because it represents a gene product rather than an activity.
obsolete frizzled-2 receptor activity (GO:0004929)
Namespace: molecular_function
Definition: OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity.
Synonyms: frizzled-2 receptor activity
Comment: This term was made obsolete because it represents a gene product rather than an activity.
G protein-coupled receptor activity (GO:0004930)
Namespace: molecular_function
Definition: Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: EBV-induced receptor; Epstein-Barr Virus-induced receptor activity; G protein coupled receptor activity; G protein linked receptor activity; G-protein coupled receptor activity; G-protein coupled receptor activity, unknown ligand; G-protein linked receptor activity; GPCR activity; ligand-dependent GPCR activity; Mas proto-oncogene receptor activity; orphan G protein coupled receptor activity; orphan G-protein coupled receptor activity; orphan GPCR activity; RDC1 receptor activity; receptor activity, G-protein coupled; SREB receptor; super conserved receptor expressed in brain receptor activity
extracellularly ATP-gated monoatomic cation channel activity (GO:0004931)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms: extracellularly ATP-gated cation channel activity; P2X receptor; purinoceptor; purinoreceptor
Comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
mating-type factor pheromone receptor activity (GO:0004932)
Namespace: molecular_function
Definition: Combining with a mating-type factor pheromone to initiate a change in cell activity.
mating-type a-factor pheromone receptor activity (GO:0004933)
Namespace: molecular_function
Definition: Combining with the mating-type a-factor pheromone to initiate a change in cell activity.
Synonyms: class D G protein coupled receptor activity; class D G-protein coupled receptor activity; class D G-protein-coupled receptor activity; class D GPCR activity
mating-type alpha-factor pheromone receptor activity (GO:0004934)
Namespace: molecular_function
Definition: Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity.
Synonyms: class D G protein coupled receptor activity; class D G-protein coupled receptor activity; class D G-protein-coupled receptor activity; class D GPCR activity
adrenergic receptor activity (GO:0004935)
Namespace: molecular_function
Definition: Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.
Synonyms: adrenoceptor activity
alpha-adrenergic receptor activity (GO:0004936)
Namespace: molecular_function
Definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors.
Synonyms: alpha adrenoceptor
alpha1-adrenergic receptor activity (GO:0004937)
Namespace: molecular_function
Definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
Synonyms: alpha1 adrenoceptor
alpha2-adrenergic receptor activity (GO:0004938)
Namespace: molecular_function
Definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.
Synonyms: alpha2 adrenoceptor
beta-adrenergic receptor activity (GO:0004939)
Namespace: molecular_function
Definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
Synonyms: beta adrenoceptor
beta1-adrenergic receptor activity (GO:0004940)
Namespace: molecular_function
Definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors.
Synonyms: beta1 adrenoceptor
beta2-adrenergic receptor activity (GO:0004941)
Namespace: molecular_function
Definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors.
Synonyms: beta2 adrenoceptor
angiotensin type II receptor activity (GO:0004945)
Namespace: molecular_function
Definition: An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.
bombesin receptor activity (GO:0004946)
Namespace: molecular_function
Definition: Combining with bombesin to initiate a change in cell activity.
calcitonin receptor activity (GO:0004948)
Namespace: molecular_function
Definition: Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
cannabinoid receptor activity (GO:0004949)
Namespace: molecular_function
Definition: Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.
Synonyms: cannaboid receptor; endocannabinoid receptor activity
chemokine receptor activity (GO:0004950)
Namespace: molecular_function
Definition: Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
dopamine neurotransmitter receptor activity (GO:0004952)
Namespace: molecular_function
Definition: Combining with the neurotransmitter dopamine to initiate a change in cell activity.
icosanoid receptor activity (GO:0004953)
Namespace: molecular_function
Definition: Combining with an icosanoid to initiate a change in cell activity.
Synonyms: eicosanoid receptor activity
prostanoid receptor activity (GO:0004954)
Namespace: molecular_function
Definition: Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity.
prostaglandin receptor activity (GO:0004955)
Namespace: molecular_function
Definition: Combining with a prostaglandin (PG) to initiate a change in cell activity.
prostaglandin D receptor activity (GO:0004956)
Namespace: molecular_function
Definition: Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.
Synonyms: PGD receptor activity; PGD(2) receptor activity
prostaglandin E receptor activity (GO:0004957)
Namespace: molecular_function
Definition: Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
Synonyms: PGE receptor activity; PGE(2) receptor activity
prostaglandin F receptor activity (GO:0004958)
Namespace: molecular_function
Definition: Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.
Synonyms: PGF receptor activity; PGF(2-alpha) receptor activity
thromboxane receptor activity (GO:0004960)
Namespace: molecular_function
Definition: Combining with a thromboxane (TXA) to initiate a change in cell activity.
Synonyms: TXA receptor activity
thromboxane A2 receptor activity (GO:0004961)
Namespace: molecular_function
Definition: Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein.
Synonyms: TXA(2) receptor activity; TXA2 receptor activity
endothelin receptor activity (GO:0004962)
Namespace: molecular_function
Definition: Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: endothelin-A receptor activity; endothelin-B receptor activity
follicle-stimulating hormone receptor activity (GO:0004963)
Namespace: molecular_function
Definition: Combining with follicle-stimulating hormone to initiate a change in cell activity.
Synonyms: follicle stimulating hormone receptor activity; FSH receptor activity
luteinizing hormone receptor activity (GO:0004964)
Namespace: molecular_function
Definition: Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity.
Synonyms: LH receptor; LHR; lutropin receptor; lutropin-choriogonadotropic hormone receptor
G protein-coupled GABA receptor activity (GO:0004965)
Namespace: molecular_function
Definition: Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G-protein coupled GABA receptor activity; GABA-B receptor activity; metabotropic GABA receptor
galanin receptor activity (GO:0004966)
Namespace: molecular_function
Definition: Combining with galanin to initiate a change in cell activity.
glucagon receptor activity (GO:0004967)
Namespace: molecular_function
Definition: Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
gonadotropin-releasing hormone receptor activity (GO:0004968)
Namespace: molecular_function
Definition: Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
Synonyms: GnRH receptor activity; gonadotrophin-releasing hormone receptor activity
histamine receptor activity (GO:0004969)
Namespace: molecular_function
Definition: Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
glutamate-gated receptor activity (GO:0004970)
Namespace: molecular_function
Definition: Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
Synonyms: ionotropic glutamate receptor activity
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'.
AMPA glutamate receptor activity (GO:0004971)
Namespace: molecular_function
Definition: An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium.
Synonyms: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; AMPA receptor activity
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
NMDA glutamate receptor activity (GO:0004972)
Namespace: molecular_function
Definition: A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.
Synonyms: N-methyl-D-aspartate selective glutamate receptor activity; NMDA receptor
Comment: The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
obsolete N-methyl-D-aspartate receptor-associated protein activity (GO:0004973)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: N-methyl-D-aspartate receptor-associated protein activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
leukotriene receptor activity (GO:0004974)
Namespace: molecular_function
Definition: Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine.
melanocortin receptor activity (GO:0004977)
Namespace: molecular_function
Definition: Combining with melanocortin to initiate a change in cell activity.
corticotropin receptor activity (GO:0004978)
Namespace: molecular_function
Definition: Combining with corticotropin to initiate a change in cell activity.
Synonyms: ACTH receptor activity; adrenocorticotropic hormone receptor activity; adrenocorticotropin receptor activity
melanocyte-stimulating hormone receptor activity (GO:0004980)
Namespace: molecular_function
Definition: Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
Synonyms: melanocyte stimulating hormone receptor activity; melanophore-stimulating hormone receptor activity; MSH receptor activity; MSHR activity
N-formyl peptide receptor activity (GO:0004982)
Namespace: molecular_function
Definition: Combining with an N-formyl peptide to initiate a change in cell activity.
Synonyms: Fmet-leu-phe receptor
neuropeptide Y receptor activity (GO:0004983)
Namespace: molecular_function
Definition: Combining with neuropeptide Y to initiate a change in cell activity.
olfactory receptor activity (GO:0004984)
Namespace: molecular_function
Definition: Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
Synonyms: odorant receptor activity
G protein-coupled opioid receptor activity (GO:0004985)
Namespace: molecular_function
Definition: Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.
Synonyms: opioid receptor activity
obsolete delta-opioid receptor activity (GO:0004986)
Namespace: molecular_function
Definition: OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands.
Synonyms: delta-opioid receptor activity
Comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.