LiteFold/GO huggingface dataset:
pre-replicative complex (GO:0036387)
Namespace: cellular_component
Definition: A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.
Synonyms: pre-RC; pre-replication complex
Comment: This term describes pre-replicative complexes across organisms.
pre-replicative complex assembly (GO:0036388)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.
Synonyms: pre-RC assembly; pre-replication complex assembly
bacterial pre-replicative complex (GO:0036389)
Namespace: cellular_component
Definition: A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.
Synonyms: bacterial pre-RC
obsolete pre-replicative complex assembly involved in bacterial-type DNA replication (GO:0036390)
Namespace: biological_process
Definition: OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.
Synonyms: bacterial pre-RC assembly; bacterial pre-replicative complex assembly
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
medial cortex septin ring (GO:0036391)
Namespace: cellular_component
Definition: A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins.
chemokine (C-C motif) ligand 20 production (GO:0036392)
Namespace: biological_process
Definition: The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: C-C motif chemokine 20 production; CCL-20 production; CCL20 production
thiocyanate peroxidase activity (GO:0036393)
Namespace: molecular_function
Definition: Catalysis of the reaction: thiocyanate + H2O2 + H+ = hypothiocyanous acid + H2O.
Synonyms: lactoperoxidase activity
pancreatic amylase secretion (GO:0036395)
Namespace: biological_process
Definition: The controlled release of amylase from a cell of the pancreas.
RNA N6-methyladenosine methyltransferase complex (GO:0036396)
Namespace: cellular_component
Definition: A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
Synonyms: m(6)A writer complex; m6A methyltransferase complex; METTL3-METTL14-WTAP methyltransferase complex; MIS complex; Mum2, Ime4, and Slz1 complex; WMM complex
formate dehydrogenase (quinone) activity (GO:0036397)
Namespace: molecular_function
Definition: Catalysis of the reaction: formate + a quinone = CO2 + a quinol.
Synonyms: Fdh-N activity; formate dehydrogenase-N activity; formate:quinone oxidoreductase activity
TCR signalosome (GO:0036398)
Namespace: cellular_component
Definition: A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.
Synonyms: LAT signalosome; linker for activation of T cells signalosome
TCR signalosome assembly (GO:0036399)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome.
Synonyms: LAT signalosome assembly; linker for activation of T cells signalosome assembly
short neuropeptide F receptor activity (GO:0036400)
Namespace: molecular_function
Definition: Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide.
Synonyms: sNPF receptor activity
Comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related.
proteasome-activating activity (GO:0036402)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
Synonyms: ATPase involved in positive regulation of proteasomal protein catabolic process; proteasomal ATPase activity; proteasome channel gating activity; proteasome channel opening activity; proteasome-activating ATPase activity
obsolete conversion of ds siRNA to ss siRNA (GO:0036404)
Namespace: biological_process
Definition: OBSOLETE. The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA).
Synonyms: conversion of double-stranded small interfering RNA to single-stranded small interfering RNA
Comment: This term was obsoleted because it represents a molecular function.
obsolete anchored component of cell outer membrane (GO:0036405)
Namespace: cellular_component
Definition: OBSOLETE. The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
Synonyms: anchored to cell outer membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete anchored component of periplasmic side of cell outer membrane (GO:0036406)
Namespace: cellular_component
Definition: OBSOLETE. The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only.
Synonyms: anchored to internal side of cell outer membrane; anchored to periplasmic side of cell outer membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
mycolate outer membrane (GO:0036407)
Namespace: cellular_component
Definition: A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria).
Synonyms: MOM; mycobacterial outer membrane; mycomembrane
histone H3K14 acetyltransferase activity (GO:0036408)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).
Synonyms: histone acetylase activity (H3-K14 specific); histone acetyltransferase activity (H3-K14 specific); histone H3-K14 acetyltransferase activity; histone lysine N-acetyltransferase activity (H3-K14 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3-K14 acetyltransferase complex (GO:0036409)
Namespace: cellular_component
Definition: A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3.
Synonyms: H3-K14 histone acetyltransferase complex; histone acetyltransferase complex (H3-K14 specific); histone H3 Lys 14 (H3K14) acetyltransferase complex; histone H3K14 acetyltransferase complex
Mst2 histone acetyltransferase complex (GO:0036410)
Namespace: cellular_component
Definition: A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6.
Synonyms: Mst2 complex; Mst2 H3K14 acetyltransferase complex; Mst2 histone H3K14 acetyltransferase complex
H-NS-Cnu complex (GO:0036411)
Namespace: cellular_component
Definition: A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes.
acetyl-CoA:oxalate CoA-transferase activity (GO:0036412)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA.
obsolete histone H3-R26 citrullination (GO:0036413)
Namespace: biological_process
Definition: OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3.
Synonyms: histone H3 arginine 26 citrullination
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone citrullination (GO:0036414)
Namespace: biological_process
Definition: OBSOLETE. The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein.
Synonyms: histone deimination
Comment: This term was obsoleted because it represents a molecular function.
regulation of tRNA stability (GO:0036415)
Namespace: biological_process
Definition: Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs.
tRNA destabilization (GO:0036417)
Namespace: biological_process
Definition: Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes.
obsolete intrinsic component of mycolate outer membrane (GO:0036418)
Namespace: cellular_component
Definition: OBSOLETE. The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
Synonyms: intrinsic to MOM; intrinsic to mycolate outer membrane; intrinsic to mycomembrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of mycolate outer membrane (GO:0036419)
Namespace: cellular_component
Definition: OBSOLETE. The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral to MOM; integral to mycolate outer membrane; integral to mycomembrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
extrinsic component of mycolate outer membrane (GO:0036420)
Namespace: cellular_component
Definition: The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
Synonyms: extrinsic to MOM; extrinsic to mycolate outer membrane; extrinsic to mycomembrane
extrinsic component of external side of mycolate outer membrane (GO:0036421)
Namespace: cellular_component
Definition: The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
Synonyms: extrinsic to external side of MOM; extrinsic to external side of mycolate outer membrane; extrinsic to external side of mycomembrane
hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity (GO:0036423)
Namespace: molecular_function
Definition: Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate.
Synonyms: hexaprenyl diphosphate synthase activity; hexaprenyl pyrophosphate synthetase activity; HexPS activity
L-phosphoserine phosphatase activity (GO:0036424)
Namespace: molecular_function
Definition: Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid.
Synonyms: O-phosphoserine phosphohydrolase activity; phosphoserine phosphatase activity
Comment: Do not confuse with protein phosphatases. For protein phosphatases, consider GO:0004722 ; protein serine/threonine phosphatase activity or GO:0008138 ; protein tyrosine/serine/threonine phosphatase activity.
obsolete D-phosphoserine phosphatase activity (GO:0036425)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: O-phospho-D-serine + H2O = L-serine + phosphate, on a free amino acid.
Comment: This term was obsoleted because there is no evidence that this function exists. This reaction corresponds to RHEA:24873 and KEGG_REACTION:R02853.
all-trans-undecaprenyl-phosphate mannosyltransferase activity (GO:0036427)
Namespace: molecular_function
Definition: Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP.
obsolete adenosylcobinamide kinase (GTP-specific) activity (GO:0036428)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+.
Comment: The reason for obsoletion is that this is more specific than the specificity of any known gene product.
obsolete adenosylcobinamide kinase (ATP-specific) activity (GO:0036429)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+.
Comment: The reason for obsoletion is that this is more specific than the specificity of any known gene product.
CMP kinase activity (GO:0036430)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + CMP = ADP + CDP.
dCMP kinase activity (GO:0036431)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + dCMP = ADP + dCDP.
Synonyms: ATP:dCMP phosphotransferase activity
all-trans undecaprenol kinase activity (GO:0036432)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+.
di-trans, poly-cis-undecaprenol kinase activity (GO:0036433)
Namespace: molecular_function
Definition: Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+.
Synonyms: ditrans,polycis-undecaprenol kinase activity
nitronate monooxygenase (FMN-linked) activity (GO:0036434)
Namespace: molecular_function
Definition: Catalysis of the reaction: ethylnitronate + FMNH(2) + O2 = acetaldehyde + FMN + H2O + H+ + nitrite.
K48-linked polyubiquitin modification-dependent protein binding (GO:0036435)
Namespace: molecular_function
Definition: Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.
Isw1a complex (GO:0036436)
Namespace: cellular_component
Definition: An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p.
Isw1b complex (GO:0036437)
Namespace: cellular_component
Definition: An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p.
maintenance of lens transparency (GO:0036438)
Namespace: biological_process
Definition: A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.
Synonyms: maintenance of ocular lens transparency; preservation of lens transparency
citrate synthase activity (GO:0036440)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
Synonyms: (R)-citrate synthase activity; (R)-citric synthase activity; acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]; acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]; citrate (Re)-synthase activity; citrate (Si)-synthase activity; citrate condensing enzyme activity; citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity; citrate oxaloacetate-lyase ((pro-3R)-CH2COO-rightacetyl-CoA); citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity; citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA); citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]; citrate oxaloacetate-lyase, CoA-acetylating activity; citrate synthetase activity; citric synthase activity; citric-condensing enzyme activity; citrogenase activity; condensing enzyme activity; oxalacetic transacetase activity; oxaloacetate transacetase activity; Re-citrate-synthase activity
2-dehydropantolactone reductase activity (GO:0036441)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+.
obsolete dermatan 6-sulfotransferase activity (GO:0036443)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate.
Comment: This term was obsoleted because it is not known to be catalyzed by any gene product.
calcium import into the mitochondrion (GO:0036444)
Namespace: biological_process
Definition: A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
Synonyms: calcium ion import into mitochondrion; calcium ion transmembrane import into mitochondrion; mitochondrial calcium ion import; mitochondrial calcium uptake
neuronal stem cell division (GO:0036445)
Namespace: biological_process
Definition: The self-renewing division of a neuronal stem cell.
Synonyms: NSC division
myofibroblast differentiation (GO:0036446)
Namespace: biological_process
Definition: The process in which an undifferentiated cell acquires the features of a myofibroblast cell.
Synonyms: myofibroblast cell differentiation
cellular response to sugar-phosphate stress (GO:0036447)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate.
Synonyms: cellular response to presence of non-metabolizable sugars
cellular response to glucose-phosphate stress (GO:0036448)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate.
microtubule minus-end (GO:0036449)
Namespace: cellular_component
Definition: The end of a microtubule that does not preferentially grow (polymerize).
Synonyms: microtubule minus end
polyuridylation-dependent decapping of nuclear-transcribed mRNA (GO:0036450)
Namespace: biological_process
Definition: Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end.
Synonyms: uridylation-dependent decapping of nuclear-transcribed mRNA
obsolete cap mRNA methylation (GO:0036451)
Namespace: biological_process
Definition: OBSOLETE. Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA.
Comment: The reason for obsoletion is that this term represents a molecular function.
transitive RNA interference (GO:0036453)
Namespace: biological_process
Definition: An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence.
Synonyms: transitive RNAi
growth factor complex (GO:0036454)
Namespace: cellular_component
Definition: A protein complex that has growth factor activity.
iron-sulfur transferase activity (GO:0036455)
Namespace: molecular_function
Definition: Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor).
Synonyms: Fe-S transferase activity
obsolete L-methionine-(S)-S-oxide reductase activity (GO:0036456)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O.
Comment: The reason for obsoletion is that it more specific than the specificity of any known gene product.
keratohyalin granule (GO:0036457)
Namespace: cellular_component
Definition: A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope.
hepatocyte growth factor binding (GO:0036458)
Namespace: molecular_function
Definition: Binding to a hepatocyte growth factor.
Synonyms: HGF binding
cellular response to cell envelope stress (GO:0036460)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope.
Synonyms: envelope stress response
BLOC-2 complex binding (GO:0036461)
Namespace: molecular_function
Definition: Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.
TRAIL-activated apoptotic signaling pathway (GO:0036462)
Namespace: biological_process
Definition: An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.
Synonyms: TRAIL-activated extrinsic apoptotic signaling pathway; TRAIL-induced apoptotic signaling pathway; tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway
cytoplasmic ribonucleoprotein granule (GO:0036464)
Namespace: cellular_component
Definition: A ribonucleoprotein granule located in the cytoplasm.
Synonyms: Staufen granule
synaptic vesicle recycling (GO:0036465)
Namespace: biological_process
Definition: The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.
Synonyms: kiss-and-run synaptic vesicle recycling; kiss-and-stay synaptic vesicle recycling
synaptic vesicle recycling via endosome (GO:0036466)
Namespace: biological_process
Definition: Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.
Synonyms: recycling endosome localization within postsynapse
5-hydroxy-L-tryptophan decarboxylase activity (GO:0036467)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin.
Synonyms: 5-hydroxytryptophan decarboxylase activity
L-dopa decarboxylase activity (GO:0036468)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine.
Synonyms: 4-dihydroxyl-L-phenylalanine decarboxylase activity; DDC activity; DOPA decarboxylase activity