LiteFold/GO huggingface dataset:
interleukin-4-dependent isotype switching to IgE isotypes (GO:0035708)
Namespace: biological_process
Definition: The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4).
Synonyms: IL-4-dependent isotype switching to IgE isotypes
memory T cell activation (GO:0035709)
Namespace: biological_process
Definition: The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
CD4-positive, alpha-beta T cell activation (GO:0035710)
Namespace: biological_process
Definition: The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
T-helper 1 cell activation (GO:0035711)
Namespace: biological_process
Definition: The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Synonyms: Th1 cell activation
T-helper 2 cell activation (GO:0035712)
Namespace: biological_process
Definition: The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Synonyms: Th2 cell activation
response to nitrogen dioxide (GO:0035713)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.
Synonyms: response to NO2
cellular response to nitrogen dioxide (GO:0035714)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.
Synonyms: cellular response to NO2
chemokine (C-C motif) ligand 12 binding (GO:0035716)
Namespace: molecular_function
Definition: Binding to chemokine (C-C motif) ligand 12.
Synonyms: CCL12 binding
chemokine (C-C motif) ligand 7 binding (GO:0035717)
Namespace: molecular_function
Definition: Binding to chemokine (C-C motif) ligand 7.
Synonyms: CCL7 binding
macrophage migration inhibitory factor binding (GO:0035718)
Namespace: molecular_function
Definition: Binding to the cytokine, macrophage migration inhibitory factor.
Synonyms: MIF binding
tRNA import into nucleus (GO:0035719)
Namespace: biological_process
Definition: The directed movement of tRNA from the cytoplasm to the nucleus.
Synonyms: retrograde tRNA transport into nucleus; tRNA nuclear import
intraciliary anterograde transport (GO:0035720)
Namespace: biological_process
Definition: The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins.
Synonyms: intraflagellar anterograde transport
Comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
intraciliary retrograde transport (GO:0035721)
Namespace: biological_process
Definition: The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins.
Synonyms: intraflagellar retrograde transport
Comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
interleukin-12-mediated signaling pathway (GO:0035722)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-12-mediated signaling pathway; interleukin-12-mediated signalling pathway
interleukin-15-mediated signaling pathway (GO:0035723)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-15 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-15-mediated signaling pathway; interleukin-15-mediated signalling pathway
obsolete CD24 biosynthetic process (GO:0035724)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation.
Synonyms: CD24 anabolism; CD24 biosynthesis; CD24 formation; CD24 synthesis
Comment: The reason for obsoletion is that this term represents a gene product.
sodium ion transmembrane transport (GO:0035725)
Namespace: biological_process
Definition: A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
Synonyms: sodium ion membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
common myeloid progenitor cell proliferation (GO:0035726)
Namespace: biological_process
Definition: The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
lysophosphatidic acid binding (GO:0035727)
Namespace: molecular_function
Definition: Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.
Synonyms: LPA binding
response to hepatocyte growth factor (GO:0035728)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
Synonyms: response to hepatocyte growth factor stimulus; response to HGF stimulus
cellular response to hepatocyte growth factor stimulus (GO:0035729)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.
Synonyms: cellular response to HGF stimulus
dinitrosyl-iron complex binding (GO:0035731)
Namespace: molecular_function
Definition: Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.
Synonyms: dinitrosyl-diglutathionyl-iron complex binding; DNDGIC binding; DNIC binding
nitric oxide storage (GO:0035732)
Namespace: biological_process
Definition: The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.
Synonyms: NO storage
hepatic stellate cell activation (GO:0035733)
Namespace: biological_process
Definition: A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.
intraciliary transport involved in cilium assembly (GO:0035735)
Namespace: biological_process
Definition: The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
Synonyms: intraciliary transport involved in cilium morphogenesis; intraflagellar transport; intraflagellar transport involved in cilium morphogenesis
cell proliferation involved in compound eye morphogenesis (GO:0035736)
Namespace: biological_process
Definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.
obsolete injection of substance in to other organism (GO:0035737)
Namespace: biological_process
Definition: OBSOLETE. The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes.
Comment: This term was obsoleted because it is specific to species that delivers venoms by biting; other organisms deliver venoms by other mechanisms, such as direct skin contact. Hence this terms describes a species rather than a specific process.
venom-mediated perturbation of biological process (GO:0035738)
Namespace: biological_process
Definition: A process by which an organism alters or subverts a biological process in another organism via the action of a venom. Venoms are injected into the prey by a bite or a sting. Venoms cause their biological effects via the many toxins that they contain; some venoms are complex mixtures of toxins of differing types. Venoms can serve as predation mechanisms or defense responses.
Synonyms: envenomation; envenomation perturbing biological process; envenomation resulting in modification of morphology or physiology of other organism; envenomation resulting in modulation of process in another organism; envenomation resulting in modulation of process in other organism
CD4-positive, alpha-beta T cell proliferation (GO:0035739)
Namespace: biological_process
Definition: The expansion of a CD4-positive, alpha-beta T cell population by cell division.
CD8-positive, alpha-beta T cell proliferation (GO:0035740)
Namespace: biological_process
Definition: The expansion of a CD8-positive, alpha-beta T cell population by cell division.
activated CD4-positive, alpha-beta T cell proliferation (GO:0035741)
Namespace: biological_process
Definition: The expansion of an activated CD4-positive, alpha-beta T cell population by cell division.
activated CD8-positive, alpha-beta T cell proliferation (GO:0035742)
Namespace: biological_process
Definition: The expansion of an activated CD8-positive, alpha-beta T cell population by cell division.
CD4-positive, alpha-beta T cell cytokine production (GO:0035743)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
T-helper 1 cell cytokine production (GO:0035744)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a T-helper 1 cell.
Synonyms: Th1 cell cytokine production
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
T-helper 2 cell cytokine production (GO:0035745)
Namespace: biological_process
Definition: Any process that contributes to cytokine production by a T-helper 2 cell.
Synonyms: Th2 cell cytokine production
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
natural killer cell chemotaxis (GO:0035747)
Namespace: biological_process
Definition: The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
myelin sheath abaxonal region (GO:0035748)
Namespace: cellular_component
Definition: The region of the myelin sheath furthest from the axon.
myelin sheath adaxonal region (GO:0035749)
Namespace: cellular_component
Definition: The region of the myelin sheath nearest to the axon.
protein localization to myelin sheath abaxonal region (GO:0035750)
Namespace: biological_process
Definition: Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon.
Synonyms: protein localisation to myelin sheath abaxonal region
obsolete regulation of lysosomal lumen pH (GO:0035751)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
lysosomal lumen pH elevation (GO:0035752)
Namespace: biological_process
Definition: Any process that increases the pH of the lysosomal lumen, corresponding to a decrease in hydrogen ion concentration.
Synonyms: lysosome pH elevation
maintenance of DNA trinucleotide repeats (GO:0035753)
Namespace: biological_process
Definition: Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs.
B cell chemotaxis (GO:0035754)
Namespace: biological_process
Definition: The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cardiolipin phospholipase D activity (GO:0035755)
Namespace: molecular_function
Definition: Catalysis of the reaction: a cardiolipin + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+).
Synonyms: cardiolipin hydrolase activity
symbiont-mediated migration across host transepithelium (GO:0035756)
Namespace: biological_process
Definition: A process in which a symbiont moves from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: migration in host through an epithelial cell layer; migration of symbiont within host by transepithelial trafficking; symbiont-mediated migration through host transepithelium; transepithelial migration of symbiont in host; transmigration of symbiont in host
chemokine (C-C motif) ligand 19 binding (GO:0035757)
Namespace: molecular_function
Definition: Binding to chemokine (C-C motif) ligand 19.
Synonyms: CCL19 binding
chemokine (C-C motif) ligand 21 binding (GO:0035758)
Namespace: molecular_function
Definition: Binding to chemokine (C-C motif) ligand 21.
Synonyms: CCL21 binding
mesangial cell-matrix adhesion (GO:0035759)
Namespace: biological_process
Definition: The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney.
cytoplasmic polyadenylation-dependent rRNA catabolic process (GO:0035760)
Namespace: biological_process
Definition: The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate.
Synonyms: cytoplasmic poly(A)-dependent rRNA catabolic process
dorsal motor nucleus of vagus nerve maturation (GO:0035761)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state.
dorsal motor nucleus of vagus nerve morphogenesis (GO:0035762)
Namespace: biological_process
Definition: The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form.
dorsal motor nucleus of vagus nerve structural organization (GO:0035763)
Namespace: biological_process
Definition: The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure.
Synonyms: dorsal motor nucleus of vagus nerve structural organisation
dorsal motor nucleus of vagus nerve formation (GO:0035764)
Namespace: biological_process
Definition: The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts.
obsolete motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation (GO:0035765)
Namespace: biological_process
Definition: OBSOLETE. The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
cell chemotaxis to fibroblast growth factor (GO:0035766)
Namespace: biological_process
Definition: The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF).
endothelial cell chemotaxis (GO:0035767)
Namespace: biological_process
Definition: The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
endothelial cell chemotaxis to fibroblast growth factor (GO:0035768)
Namespace: biological_process
Definition: The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF).
B cell chemotaxis across high endothelial venule (GO:0035769)
Namespace: biological_process
Definition: The movement of a B cell to cross a high endothelial venule in response to an external stimulus.
Synonyms: B-cell chemotaxis across high endothelial venule
ribonucleoprotein granule (GO:0035770)
Namespace: cellular_component
Definition: A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.
Synonyms: mRNP granule; RNA granule; RNP granule
interleukin-4-mediated signaling pathway (GO:0035771)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-4 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-4-mediated signaling pathway; interleukin-4-mediated signalling pathway
interleukin-13-mediated signaling pathway (GO:0035772)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-13 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-13-mediated signaling pathway; interleukin-13-mediated signalling pathway
insulin secretion involved in cellular response to glucose stimulus (GO:0035773)
Namespace: biological_process
Definition: The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.
Synonyms: insulin secretion involved in cellular response to glucose
positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
Synonyms: positive regulation of insulin secretion in response to glucose
pronephric glomerulus morphogenesis (GO:0035775)
Namespace: biological_process
Definition: The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
Comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus.
pronephric proximal tubule development (GO:0035776)
Namespace: biological_process
Definition: The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.
pronephric distal tubule development (GO:0035777)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.
pronephric nephron tubule epithelial cell differentiation (GO:0035778)
Namespace: biological_process
Definition: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state.
angioblast cell differentiation (GO:0035779)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).
Synonyms: angioblastic mesenchymal cell differentiation
obsolete CD80 biosynthetic process (GO:0035780)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival.
Synonyms: CD80 anabolism; CD80 biosynthesis; CD80 formation; CD80 synthesis
Comment: The reason for obsoletion is that this term represents a gene product.
obsolete CD86 biosynthetic process (GO:0035781)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival.
Synonyms: CD86 anabolism; CD86 biosynthesis; CD86 formation; CD86 synthesis
Comment: The reason for obsoletion is that this term represents a gene product.
mature natural killer cell chemotaxis (GO:0035782)
Namespace: biological_process
Definition: The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules.
Synonyms: activated natural killer cell chemotaxis
CD4-positive, alpha-beta T cell costimulation (GO:0035783)
Namespace: biological_process
Definition: The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.
Synonyms: CD4-positive, alpha beta T cell costimulation
obsolete nickel cation homeostasis (GO:0035784)
Namespace: biological_process
Definition: OBSOLETE. Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell.
Synonyms: nickel homeostasis
Comment: The term is not clearly defined and usage has been inconsistent. For homeostasis terms, we would like to specify whether the homeostasis takes place intracellularly or at the level of the organism.