LiteFold/GO huggingface dataset:
neuropeptide receptor activity (GO:0008188)
Namespace: molecular_function
Definition: Combining with a neuropeptide to initiate a change in cell activity.
obsolete apoptosis inhibitor activity (GO:0008189)
Namespace: molecular_function
Definition: OBSOLETE. The function held by products which directly block any step in the process of apoptosis.
Synonyms: apoptosis inhibitor activity
Comment: This term was made obsolete because it represents involvement in a biological process.
eukaryotic initiation factor 4E binding (GO:0008190)
Namespace: molecular_function
Definition: Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.
Synonyms: eIF4E binding
metalloendopeptidase inhibitor activity (GO:0008191)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
Synonyms: metalloprotease inhibitor; metalloproteinase inhibitor
RNA guanylyltransferase activity (GO:0008192)
Namespace: molecular_function
Definition: Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule.
tRNA guanylyltransferase activity (GO:0008193)
Namespace: molecular_function
Definition: Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.
UDP-glycosyltransferase activity (GO:0008194)
Namespace: molecular_function
Definition: Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.
phosphatidate phosphatase activity (GO:0008195)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Synonyms: 3-sn-phosphatidate phosphohydrolase activity; acid phosphatidyl phosphatase activity; phosphatic acid phosphatase activity; phosphatic acid phosphohydrolase activity; phosphatidate phosphohydrolase activity; phosphatidic acid phosphatase activity
vitellogenin receptor activity (GO:0008196)
Namespace: molecular_function
Definition: Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis.
obsolete yolk protein (GO:0008197)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: yolk protein
Comment: This term was made obsolete because it does not represent a molecular function.
ferrous iron binding (GO:0008198)
Namespace: molecular_function
Definition: Binding to a ferrous iron ion, Fe(II).
ferric iron binding (GO:0008199)
Namespace: molecular_function
Definition: Binding to a ferric iron ion, Fe(III).
ion channel inhibitor activity (GO:0008200)
Namespace: molecular_function
Definition: Binds to and stops, prevents, or reduces the activity of an ion channel.
heparin binding (GO:0008201)
Namespace: molecular_function
Definition: Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
Synonyms: heparan sulfate binding
steroid metabolic process (GO:0008202)
Namespace: biological_process
Definition: The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
Synonyms: steroid metabolism
cholesterol metabolic process (GO:0008203)
Namespace: biological_process
Definition: The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
Synonyms: cholesterol metabolism
ergosterol metabolic process (GO:0008204)
Namespace: biological_process
Definition: The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light.
Synonyms: ergosterol metabolism
ecdysone metabolic process (GO:0008205)
Namespace: biological_process
Definition: The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development.
Synonyms: ecdysone metabolism
bile acid metabolic process (GO:0008206)
Namespace: biological_process
Definition: The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
Synonyms: bile acid metabolism
C21-steroid hormone catabolic process (GO:0008208)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
Synonyms: C21-steroid hormone breakdown; C21-steroid hormone catabolism; C21-steroid hormone degradation
androgen metabolic process (GO:0008209)
Namespace: biological_process
Definition: The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
Synonyms: androgen metabolism
estrogen metabolic process (GO:0008210)
Namespace: biological_process
Definition: The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
Synonyms: estrogen metabolism; oestrogen metabolic process; oestrogen metabolism
glucocorticoid metabolic process (GO:0008211)
Namespace: biological_process
Definition: The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
Synonyms: glucocorticoid metabolism; glucocorticosteroid metabolic process; glucocorticosteroid metabolism
mineralocorticoid metabolic process (GO:0008212)
Namespace: biological_process
Definition: The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance.
Synonyms: mineralocorticoid metabolism
protein alkylation (GO:0008213)
Namespace: biological_process
Definition: The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom.
Synonyms: protein amino acid alkylation
protein dealkylation (GO:0008214)
Namespace: biological_process
Definition: The removal of an alkyl group from a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom.
Synonyms: protein amino acid dealkylation
spermine metabolic process (GO:0008215)
Namespace: biological_process
Definition: The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.
Synonyms: spermine metabolism
regulation of blood pressure (GO:0008217)
Namespace: biological_process
Definition: Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
Synonyms: blood pressure homeostasis; blood pressure regulation; control of blood pressure
bioluminescence (GO:0008218)
Namespace: biological_process
Definition: The production of light by certain enzyme-catalyzed reactions in cells.
cell death (GO:0008219)
Namespace: biological_process
Definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
Synonyms: accidental cell death; necrosis
Comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.
obsolete necrosis (GO:0008220)
Namespace: biological_process
Definition: OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism.
Synonyms: necrosis
Comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created.
obsolete tumor antigen (GO:0008222)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: tumor antigen
Comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
obsolete Gram-positive antibacterial peptide activity (GO:0008224)
Namespace: molecular_function
Definition: OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells.
Synonyms: Gram-positive antibacterial peptide activity
Comment: This term was made obsolete because it describes involvement in a process and not a function.
tyramine receptor activity (GO:0008226)
Namespace: molecular_function
Definition: Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine.
G protein-coupled amine receptor activity (GO:0008227)
Namespace: molecular_function
Definition: Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: amine receptor activity, G-protein coupled; biogenic amine receptor; G-protein coupled amine receptor activity
opsonization (GO:0008228)
Namespace: biological_process
Definition: The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.
obsolete opsonin activity (GO:0008229)
Namespace: molecular_function
Definition: OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis.
Synonyms: opsonin activity
Comment: This term was made obsolete because it represents a class of gene products.
ecdysone receptor holocomplex (GO:0008230)
Namespace: cellular_component
Definition: A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes.
repressor ecdysone receptor complex (GO:0008231)
Namespace: cellular_component
Definition: A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.
Synonyms: repressor ecdysone receptor holocomplex
cysteine-type peptidase activity (GO:0008234)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Synonyms: cysteine protease activity; thiol protease activity
metalloexopeptidase activity (GO:0008235)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
serine-type peptidase activity (GO:0008236)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Synonyms: serine protease activity
metallopeptidase activity (GO:0008237)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms: metalloprotease activity; metalloproteinase activity
exopeptidase activity (GO:0008238)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
Synonyms: exoprotease activity
dipeptidyl-peptidase activity (GO:0008239)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.
tripeptidyl-peptidase activity (GO:0008240)
Namespace: molecular_function
Definition: Catalysis of the release of an N-terminal tripeptide from a polypeptide.
peptidyl-dipeptidase activity (GO:0008241)
Namespace: molecular_function
Definition: Catalysis of the release of C-terminal dipeptides from a polypeptide chain.
omega peptidase activity (GO:0008242)
Namespace: molecular_function
Definition: Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes.
Synonyms: peptidase activity, acting on peptides containing modified amino acids
obsolete plasminogen activator activity (GO:0008243)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin.
Synonyms: abbokinase activity; cellular plasminogen activator activity; double-chain urokinase-type plasminogen activator; plasminogen activator activity; plasminogen activator, tissue-type; t-PA; t-plasminogen activator activity; tissue plasminogen activator activity; tissue-type plasminogen activator activity; tPA activity; two-chain urokinase-type plasminogen activator; u-PA; u-plasminogen activator activity; uPA; urinary esterase A; urinary plasminogen activator activity; urokinase activity; urokinase plasminogen activator; urokinase-type plasminogen activator
Comment: This term was made obsolete because it represents a gene product.
obsolete lysosomal membrane hydrogen-transporting ATPase (GO:0008245)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: lysosomal membrane hydrogen-transporting ATPase; V-ATPase
Comment: This term was made obsolete because more specific terms were created.
obsolete electron transfer flavoprotein (GO:0008246)
Namespace: molecular_function
Definition: OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system.
Synonyms: electron transfer flavoprotein; ETF
Comment: This term was made obsolete because it refers to a class of gene products.
1-alkyl-2-acetylglycerophosphocholine esterase complex (GO:0008247)
Namespace: cellular_component
Definition: An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF).
Synonyms: 2-acetyl-1-alkylglycerophosphocholine esterase complex; platelet-activating factor acetylhydrolase complex
Comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'.
oligosaccharyltransferase complex (GO:0008250)
Namespace: cellular_component
Definition: A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. The complex includes at least eight non-identical subunits. Different forms of the complex containing distinct subunits have been detected in mammals.
Synonyms: oligosaccharyl transferase complex; OST complex; OSTCI; OSTCII; OSTCIII
tRNA-specific adenosine deaminase activity (GO:0008251)
Namespace: molecular_function
Definition: Catalysis of the reaction: adenosine + H2O = inosine + NH4+, in a tRNA molecule.
Synonyms: tRNA-adenosine deaminase activity
nucleotidase activity (GO:0008252)
Namespace: molecular_function
Definition: Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.
Synonyms: acid nucleotidase activity; deoxyinosine-activated nucleotidase (DIAN); deoxyribonucleoside-activated nucleotidase (DAN); NSP I; NSP II; nucleotide phosphohydrolase activity; nucleotide-specific phosphatase activity
5'-nucleotidase activity (GO:0008253)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
Synonyms: 5' nucleotidase activity; 5'-adenylic phosphatase; 5'-AMP nucleotidase; 5'-AMPase; 5'-mononucleotidase activity; 5'-ribonucleotide phosphohydrolase activity; adenosine 5'-phosphatase; adenosine monophosphatase; AMP phosphatase; AMP phosphohydrolase; AMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; UMPase; uridine 5'-nucleotidase
ecdysis-triggering hormone activity (GO:0008255)
Namespace: molecular_function
Definition: The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.
protein histidine pros-kinase activity (GO:0008256)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine.
Synonyms: ATP:protein-L-histidine N-pros-phosphotransferase activity; ATP:protein-L-histidine Npi-phosphotransferase activity; protein-histidine pros-kinase activity
protein histidine tele-kinase activity (GO:0008257)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine.
Synonyms: ATP:protein-L-histidine N-tele-phosphotransferase activity; ATP:protein-L-histidine Ntau-phosphotransferase activity; protein-histidine tele-kinase activity
head involution (GO:0008258)
Namespace: biological_process
Definition: Movement of the anterior ectoderm to the interior of the embryo.
obsolete transforming growth factor beta ligand binding to type I receptor (GO:0008259)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: TGF-beta ligand binding to type I receptor; TGFbeta ligand binding to type I receptor; transforming growth factor beta ligand binding to type I receptor
Comment: This term was made obsolete because it represents a function.
succinyl-CoA:3-oxo-acid CoA-transferase activity (GO:0008260)
Namespace: molecular_function
Definition: Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.
Synonyms: 3-oxo-CoA transferase activity; 3-oxoacid CoA dehydrogenase activity; 3-oxoacid CoA-transferase activity; 3-oxoacid coenzyme A-transferase activity; acetoacetate succinyl-CoA transferase activity; acetoacetyl coenzyme A-succinic thiophorase activity; succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity; succinyl-CoA 3-ketoacid-CoA transferase activity; succinyl-CoA transferase activity; Succinyl-CoA:3-ketoacid-CoA transferase
allatostatin receptor activity (GO:0008261)
Namespace: molecular_function
Definition: Combining with allatostatin to initiate a change in cell activity.
pyrimidine-specific mismatch base pair DNA N-glycosylase activity (GO:0008263)
Namespace: molecular_function
Definition: Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.
Synonyms: G/T-mismatch-specific thymine-DNA glycosylase activity
molybdenum cofactor sulfurtransferase activity (GO:0008265)
Namespace: molecular_function
Definition: Catalysis of the reaction: AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin.
Synonyms: Mo-molybdopterin cofactor sulfurase activity; Mo-molybdopterin cofactor sulphurase activity; molybdopterin cofactor sulfurase activity; molybdopterin synthase sulfurylase activity
poly(U) RNA binding (GO:0008266)
Namespace: molecular_function
Definition: Binding to a sequence of uracil residues in an RNA molecule.
Synonyms: poly(U) binding
poly-glutamine tract binding (GO:0008267)
Namespace: molecular_function
Definition: Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.
zinc ion binding (GO:0008270)
Namespace: molecular_function
Definition: Binding to a zinc ion (Zn).
Synonyms: zinc binding; Zn binding
secondary active sulfate transmembrane transporter activity (GO:0008271)
Namespace: molecular_function
Definition: Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: secondary active sulphate transmembrane transporter activity; sulfate porter activity; sulphate porter activity
obsolete sulfate transport (GO:0008272)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: sulphate transport
Comment: The reason for obsoletion is that this term is equivalent to sulphate transmembrane transport.
calcium, potassium:sodium antiporter activity (GO:0008273)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
Synonyms: potassium-dependent sodium/calcium exchanger