LiteFold/GO huggingface dataset:
rRNA (uridine-C5-)-methyltransferase activity (GO:0070041)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine.
rRNA (uridine-N3-)-methyltransferase activity (GO:0070042)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine.
rRNA (guanine-N7-)-methyltransferase activity (GO:0070043)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine.
synaptobrevin 2-SNAP-25-syntaxin-1a complex (GO:0070044)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).
Synonyms: Snap25-Stx1a-Vamp2 complex; SNARE complex (Snap25, Stx1a, Vamp2); SNARE complex (Stx1a, SNAP25, VAMP); Stx1a-SNAP25-VAMP complex
synaptobrevin 2-SNAP-25-syntaxin-2 complex (GO:0070045)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof).
Synonyms: SNARE complex (Stx2, Snap25, Vamp2); Stx2-Snap25-Vamp2 complex
synaptobrevin 2-SNAP-25-syntaxin-3 complex (GO:0070046)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof).
Synonyms: SNARE complex (Stx3, Snap25, Vamp2); Stx3-Snap25-Vamp2 complex
synaptobrevin 2-SNAP-25-syntaxin-4 complex (GO:0070047)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof).
Synonyms: SNARE complex (Stx4, Snap25, Vamp2); Stx4-Snap25-Vamp2 complex
neuron cellular homeostasis (GO:0070050)
Namespace: biological_process
Definition: The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
Synonyms: neuron maintenance
fibrinogen binding (GO:0070051)
Namespace: molecular_function
Definition: Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.
collagen V binding (GO:0070052)
Namespace: molecular_function
Definition: Binding to a type V collagen trimer.
thrombospondin receptor activity (GO:0070053)
Namespace: molecular_function
Definition: Combining with thrombospondin and transmitting the signal to initiate a change in cell activity.
mRNA splicing, via endonucleolytic cleavage and ligation (GO:0070054)
Namespace: biological_process
Definition: Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
Synonyms: cytosolic mRNA splicing
Comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
obsolete mRNA endonucleolytic cleavage involved in unfolded protein response (GO:0070055)
Namespace: biological_process
Definition: OBSOLETE. The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response.
Synonyms: ERN1-mediated XBP-1 mRNA cleavage; HAC1 mRNA cleavage; HAC1-type intron splice site recognition and cleavage; IRE1-mediated XBP-1 mRNA cleavage; XBP1 mRNA cleavage
Comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498).
prospore membrane leading edge (GO:0070056)
Namespace: cellular_component
Definition: The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization.
Synonyms: forespore membrane leading edge
prospore membrane spindle pole body attachment site (GO:0070057)
Namespace: cellular_component
Definition: The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus.
Synonyms: forespore membrane SPB attachment site; forespore membrane spindle pole body attachment site; prospore membrane SPB attachment site
tRNA gene clustering (GO:0070058)
Namespace: biological_process
Definition: The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae.
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Synonyms: apoptosis in response to endoplasmic reticulum stress; apoptosis in response to ER stress; apoptosis triggered by ER stress; endoplasmic reticulum stress-induced apoptosis; ER stress-induced apoptosis; intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
'de novo' actin filament nucleation (GO:0070060)
Namespace: biological_process
Definition: The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament.
Synonyms: formin-mediated actin filament nucleation; unbranched actin filament nucleation
fructose binding (GO:0070061)
Namespace: molecular_function
Definition: Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose.
extracellular exosome (GO:0070062)
Namespace: cellular_component
Definition: A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
Synonyms: exosome; extracellular vesicular exosome
RNA polymerase binding (GO:0070063)
Namespace: molecular_function
Definition: Binding to an RNA polymerase molecule or complex.
cellubrevin-VAMP4-syntaxin-16 complex (GO:0070065)
Namespace: cellular_component
Definition: A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof).
Synonyms: SNARE complex (Vamp3, Vamp4, Stx16); Vamp3-Vamp4-Stx16 complex
cellubrevin-VAMP4-endobrevin-syntaxin-6 complex (GO:0070066)
Namespace: cellular_component
Definition: A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof).
Synonyms: SNARE complex (Vamp3, Vamp4, Vam8, Stx6); Vamp3-Vamp4-Vam8-Stx6 complex
syntaxin-6-syntaxin-16-Vti1a complex (GO:0070067)
Namespace: cellular_component
Definition: A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).
VAMP4-syntaxin-6-syntaxin-16-Vti1a complex (GO:0070068)
Namespace: cellular_component
Definition: A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof).
Synonyms: SNARE complex (Vamp4, Stx6, Stx16, Vti1a); Vamp4-Stx6-Stx16-Vti1a complex
proton-transporting V-type ATPase complex assembly (GO:0070070)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient.
Synonyms: V-ATPase assembly; V-ATPase complex assembly
proton-transporting two-sector ATPase complex assembly (GO:0070071)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane.
vacuolar proton-transporting V-type ATPase complex assembly (GO:0070072)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.
Synonyms: V-ATPase assembly; V-ATPase complex assembly
clustering of voltage-gated calcium channels (GO:0070073)
Namespace: biological_process
Definition: The process in which voltage-gated calcium channels become localized together in high densities.
Synonyms: clustering of voltage gated calcium channels; clustering of voltage-dependent calcium channels; voltage-gated calcium channel clustering
mononeme (GO:0070074)
Namespace: cellular_component
Definition: A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts.
tear secretion (GO:0070075)
Namespace: biological_process
Definition: The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium.
obsolete histone lysine demethylation (GO:0070076)
Namespace: biological_process
Definition: OBSOLETE. The modification of a histone by the removal of a methyl group from a lysine residue.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone arginine demethylation (GO:0070077)
Namespace: biological_process
Definition: OBSOLETE. The modification of a histone by the removal of a methyl group from an arginine residue.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H3-R2 demethylation (GO:0070078)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
obsolete histone H4-R3 demethylation (GO:0070079)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
titin Z domain binding (GO:0070080)
Namespace: molecular_function
Definition: Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
Synonyms: Z repeat domain binding
clathrin-sculpted monoamine transport vesicle (GO:0070081)
Namespace: cellular_component
Definition: A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines.
Synonyms: clathrin sculpted monoamine constitutive secretory pathway transport vesicle; clathrin sculpted monoamine transport vesicle
clathrin-sculpted monoamine transport vesicle lumen (GO:0070082)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle.
Synonyms: clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen; clathrin sculpted monoamine transport vesicle lumen
clathrin-sculpted monoamine transport vesicle membrane (GO:0070083)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle.
Synonyms: clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane; clathrin sculpted monoamine transport vesicle membrane
obsolete protein initiator methionine removal (GO:0070084)
Namespace: biological_process
Definition: OBSOLETE. The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein.
Synonyms: removal of initiator methionine from protein
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete glycosylation (GO:0070085)
Namespace: biological_process
Definition: OBSOLETE. The covalent attachment and further modification of carbohydrate residues to a substrate molecule.
Comment: The reason for obsoletion is that this term represents a molecular function.
chromo shadow domain binding (GO:0070087)
Namespace: molecular_function
Definition: Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
Synonyms: chromoshadow domain binding
polyhydroxyalkanoate granule (GO:0070088)
Namespace: cellular_component
Definition: An inclusion body located in the cytoplasm of prokaryotes that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR.
Synonyms: carbonosome; PHA granule; PHB granule
chloride-activated potassium channel activity (GO:0070089)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium cation by a channel that opens when a chloride ion has been bound by the channel complex or one of its constituent parts.
metaphase plate (GO:0070090)
Namespace: cellular_component
Definition: The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division.
glucagon secretion (GO:0070091)
Namespace: biological_process
Definition: The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).
regulation of glucagon secretion (GO:0070092)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the regulated release of glucagon.
negative regulation of glucagon secretion (GO:0070093)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.
Synonyms: down regulation of glucagon secretion; down-regulation of glucagon secretion; downregulation of glucagon secretion; inhibition of glucagon secretion
positive regulation of glucagon secretion (GO:0070094)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.
Synonyms: activation of glucagon secretion; stimulation of glucagon secretion; up regulation of glucagon secretion; up-regulation of glucagon secretion; upregulation of glucagon secretion
fructose-6-phosphate binding (GO:0070095)
Namespace: molecular_function
Definition: Binding to fructose 6-phosphate.
Synonyms: D-fructose 6-phosphate binding; fructose 6-phosphate binding
chemokine-mediated signaling pathway (GO:0070098)
Namespace: biological_process
Definition: The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: chemokine-mediated signalling pathway
regulation of chemokine-mediated signaling pathway (GO:0070099)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of a chemokine-mediated signaling pathway.
Synonyms: regulation of chemokine-mediated signalling pathway
negative regulation of chemokine-mediated signaling pathway (GO:0070100)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of a chemokine-mediated signaling pathway.
Synonyms: negative regulation of chemokine-mediated signalling pathway
positive regulation of chemokine-mediated signaling pathway (GO:0070101)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of a chemokine-mediated signaling pathway.
Synonyms: positive regulation of chemokine-mediated signalling pathway
regulation of interleukin-6-mediated signaling pathway (GO:0070103)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of an interleukin-6-mediated signaling pathway.
Synonyms: regulation of IL-6-mediated signaling pathway; regulation of interleukin-6-mediated signalling pathway
negative regulation of interleukin-6-mediated signaling pathway (GO:0070104)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.
Synonyms: negative regulation of IL-6-mediated signaling pathway; negative regulation of interleukin-6-mediated signalling pathway
positive regulation of interleukin-6-mediated signaling pathway (GO:0070105)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.
Synonyms: positive regulation of IL-6-mediated signaling pathway; positive regulation of interleukin-6-mediated signalling pathway
interleukin-27-mediated signaling pathway (GO:0070106)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-27 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-27-mediated signaling pathway; IL27RA/IL6ST signaling pathway; interleukin-27-mediated signalling pathway
regulation of interleukin-27-mediated signaling pathway (GO:0070107)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of an interleukin-27-mediated signaling pathway.
Synonyms: regulation of IL-27-mediated signaling pathway; regulation of IL27RA/IL6ST signaling pathway; regulation of interleukin-27-mediated signalling pathway
negative regulation of interleukin-27-mediated signaling pathway (GO:0070108)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of an interleukin-27-mediated signaling pathway.
Synonyms: negative regulation of IL-27-mediated signaling pathway; negative regulation of IL27RA/IL6ST signaling pathway; negative regulation of interleukin-27-mediated signalling pathway
positive regulation of interleukin-27-mediated signaling pathway (GO:0070109)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of an interleukin-27-mediated signaling pathway.
Synonyms: positive regulation of IL-27-mediated signaling pathway; positive regulation of IL27RA/IL6ST signaling pathway; positive regulation of interleukin-27-mediated signalling pathway
ciliary neurotrophic factor receptor complex (GO:0070110)
Namespace: cellular_component
Definition: A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.
organellar chromatophore (GO:0070111)
Namespace: cellular_component
Definition: A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora.
Synonyms: Paulinella-type chromatophore
organellar chromatophore membrane (GO:0070112)
Namespace: cellular_component
Definition: Either of the lipid bilayers that surround an organellar chromatophore.
Synonyms: Paulinella-type chromatophore membrane
organellar chromatophore inner membrane (GO:0070113)
Namespace: cellular_component
Definition: The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore.
Synonyms: Paulinella-type chromatophore inner membrane
organellar chromatophore outer membrane (GO:0070114)
Namespace: cellular_component
Definition: The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore.
Synonyms: Paulinella-type chromatophore outer membrane
organellar chromatophore intermembrane space (GO:0070115)
Namespace: cellular_component
Definition: The region between the inner and outer lipid bilayers that surround an organellar chromatophore.
Synonyms: Paulinella-type chromatophore intermembrane space
organellar chromatophore thylakoid (GO:0070116)
Namespace: cellular_component
Definition: A thylakoid located in an organellar chromatophore.
Synonyms: Paulinella-type chromatophore thylakoid
organellar chromatophore thylakoid membrane (GO:0070118)
Namespace: cellular_component
Definition: The lipid bilayer membrane of any thylakoid within an organellar chromatophore.
Synonyms: Paulinella-type chromatophore thylakoid membrane
ciliary neurotrophic factor binding (GO:0070119)
Namespace: molecular_function
Definition: Binding to the cytokine ciliary neurotrophic factor.
Synonyms: CNTF binding
ciliary neurotrophic factor-mediated signaling pathway (GO:0070120)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: ciliary neurotrophic factor-mediated signalling pathway; CNTF-mediated signaling pathway
Kupffer's vesicle development (GO:0070121)
Namespace: biological_process
Definition: The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
Synonyms: KV development
transforming growth factor beta receptor activity, type III (GO:0070123)
Namespace: molecular_function
Definition: Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.
Synonyms: betaglycan; endoglin; transforming growth factor beta ligand binding to type III receptor; type III TGF-beta receptor activity; type III TGFbeta receptor activity; type III transforming growth factor beta receptor activity
mitochondrial translational initiation (GO:0070124)
Namespace: biological_process
Definition: The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
Synonyms: mitochondrial translation initiation
mitochondrial translational elongation (GO:0070125)
Namespace: biological_process
Definition: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.
Synonyms: mitochondrial translation elongation