LiteFold/GO huggingface dataset:
multiple spine synapse organization, multiple dendrites (GO:0150091)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites.
regulation of synaptic scaling (GO:0150092)
Namespace: biological_process
Definition: A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell.
Synonyms: homeostatic synaptic scaling; regulation of homeostatic synaptic scaling
amyloid-beta clearance by transcytosis (GO:0150093)
Namespace: biological_process
Definition: The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.
glial cell-neuron signaling (GO:0150098)
Namespace: biological_process
Definition: Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.
Synonyms: glia-neuron signaling; glia-neuron signalling; glia-neurone signaling; glia-neurone signalling; glial cell- neuron signalling; glial cell-neurone signalling; glial cell-neurone singaling
neuron-glial cell signaling (GO:0150099)
Namespace: biological_process
Definition: Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.
Synonyms: neuron-glia signaling; neuron-glia signalling; neuron-glial cell signalling; neurone-glia signaling; neurone-glia signalling; neurone-glial cell signaling; neurone-glial cell signalling
regulation of microtubule anchoring at centrosome (GO:0150101)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome.
negative regulation of monocyte activation (GO:0150102)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation.
Synonyms: repression of monocyte activation
reactive gliosis (GO:0150103)
Namespace: biological_process
Definition: A coordinated response of central nervous system (CNS) glial cells-including astrocytes, microglia, and NG2 glia-to injury, infection, or disease, characterized by changes in gene expression, morphology, proliferation, and extracellular matrix production. Reactive gliosis can range from transient glial activation to the formation of a persistent glial scar border.
Synonyms: gliosis
transport across blood-brain barrier (GO:0150104)
Namespace: biological_process
Definition: The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier.
Synonyms: transport across BBB; transport across blood brain barrier
protein localization to cell-cell junction (GO:0150105)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.
regulation of protein localization to cell-cell junction (GO:0150106)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction.
positive regulation of protein localization to cell-cell junction (GO:0150107)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.
obsolete negative regulation of cholesterol esterification (GO:0150110)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol esterification.
Comment: This term was obsoleted because it represents a molecular function.
regulation of transepithelial transport (GO:0150111)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of transepithelial transport.
cell-substrate junction organization (GO:0150115)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix.
regulation of cell-substrate junction organization (GO:0150116)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of cell-substrate junction organization.
negative regulation of protein localization to cell-cell junction (GO:0150119)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction.
Synonyms: negative regulation of protein localisation to cell-cell junction
regulation of interleukin-33 production (GO:0150127)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of interleukin-33 production.
Synonyms: regulation of interleukin-33 biosynthetic process; regulation of interleukin-33 secretion
negative regulation of interleukin-33 production (GO:0150128)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production.
Synonyms: negative regulation of interleukin-33 biosynthetic process; negative regulation of interleukin-33 secretion
positive regulation of interleukin-33 production (GO:0150129)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of interleukin-33 production.
Synonyms: positive regulation of interleukin-33 biosynthetic process; positive regulation of interleukin-33 secretion
negative regulation of interleukin-37 production (GO:0150138)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production.
Synonyms: negative regulation of interleukin-37 biosynthetic process
positive regulation of interleukin-37 production (GO:0150139)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of interleukin-37 production.
Synonyms: positive regulation of interleukin-37 biosynthetic process
obsolete regulation of CD86 production (GO:0150140)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of CD86 biosynthetic process.
Synonyms: regulation of CD86 biosynthetic process
Comment: The reason for obsoletion is that this term represents a gene product.
obsolete negative regulation of CD86 production (GO:0150141)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process.
Synonyms: negative regulation of CD86 biosynthetic process
Comment: The reason for obsoletion is that this term represents a gene product.
obsolete positive regulation of CD86 production (GO:0150142)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.
Synonyms: positive regulation of CD86 biosynthetic process
Comment: The reason for obsoletion is that this term represents a gene product.
obsolete regulation of CD80 production (GO:0150143)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of CD80 biosynthetic process.
Synonyms: regulation of CD80 biosynthetic process
Comment: The reason for obsoletion is that this term represents a gene product.
obsolete negative regulation of CD80 production (GO:0150144)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process.
Synonyms: negative regulation of CD80 biosynthetic process
Comment: The reason for obsoletion is that this term represents a gene product.
obsolete positive regulation of CD80 production (GO:0150145)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process.
Synonyms: positive regulation of CD80 biosynthetic process
Comment: The reason for obsoletion is that this term represents a gene product.
cell junction disassembly (GO:0150146)
Namespace: biological_process
Definition: The disaggregation of a cell junction into its constituent components.
cell-cell junction disassembly (GO:0150147)
Namespace: biological_process
Definition: The disaggregation of a cell-cell junction into its constituent components.
regulation of interleukin-17A production (GO:0150151)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of interleukin-17A production.
Synonyms: regulation of interleukin-17A biosynthetic process
negative regulation of interleukin-17A production (GO:0150152)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production.
Synonyms: negative regulation of interleukin-17A biosynthetic process
positive regulation of interleukin-17A production (GO:0150153)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of interleukin-17A production.
Synonyms: positive regulation of interleukin-17A biosynthetic process
regulation of interleukin-34 production (GO:0150157)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of interleukin-34 production.
Synonyms: interleukin-34 biosynthetic process; regulation of interleukin-34 biosynthetic process
positive regulation of interleukin-34 production (GO:0150158)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of interleukin-34 production.
Synonyms: positive regulation of interleukin-34 biosynthetic process
negative regulation of interleukin-34 production (GO:0150159)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production.
Synonyms: negative regulation of interleukin-34 biosynthetic process
obsolete miRNA-mediated activation of transcription by RNA polymerase II (GO:0150163)
Namespace: biological_process
Definition: OBSOLETE. Any process mediated by a microRNA (miRNA) that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete miRNA-mediated regulation of transcription by RNA polymerase II (GO:0150164)
Namespace: biological_process
Definition: OBSOLETE. Any process mediated by a microRNA (miRNA) that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete miRNA-mediated inhibition of transcription by RNA polymerase II (GO:0150165)
Namespace: biological_process
Definition: OBSOLETE. Any process mediated by a microRNA (miRNA) that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete regulation of histone H3-K4 acetylation (GO:0150166)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of histone H3-K4 acetylation.
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of histone H3-K4 acetylation (GO:0150168)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 acetylation.
Comment: This term was obsoleted because it represents a molecular function.
regulation of phosphatidylcholine metabolic process (GO:0150172)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process.
obsolete negative regulation of phosphatidylcholine metabolic process (GO:0150174)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine metabolic process.
Comment: This term was obsoleted because it is an unnecessary grouping class.
regulation of phosphatidylethanolamine metabolic process (GO:0150175)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of phosphatidylethanolamine metabolic process.
obsolete positive regulation of phosphatidylethanolamine metabolic process (GO:0150176)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylethanolamine metabolic process.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete negative regulation of phosphatidylethanolamine metabolic process (GO:0150177)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylethanolamine metabolic process.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete regulation of phosphatidylserine metabolic process (GO:0150178)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete positive regulation of phosphatidylserine metabolic process (GO:0150179)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylserine metabolic process.
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete negative regulation of phosphatidylserine metabolic process (GO:0150180)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine metabolic process.
Comment: This term was obsoleted because it is an unnecessary grouping class.
regulation of interleukin-32 production (GO:0150189)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of interleukin-32 production.
Synonyms: regulation of interleukin-32 biosynthetic process; regulation of interleukin-32 secretion
negative regulation of interleukin-32 production (GO:0150190)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production.
Synonyms: negative regulation of interleukin-32 biosynthetic process; negative regulation of interleukin-32 secretion
positive regulation of interleukin-32 production (GO:0150191)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of interleukin-32 production.
Synonyms: positive regulation of interleukin-32 biosynthetic process; positive regulation of interleukin-32 secretion
transport across blood-cerebrospinal fluid barrier (GO:0150195)
Namespace: biological_process
Definition: The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier.
Synonyms: transport across BCSFB; transport across blood-CSF barrier; transport across blood/cerebrospinal fluid barrier; transport across blood/CSF barrier
regulation of transport across blood-brain barrier (GO:0150200)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier.
positive regulation of transport across blood-brain barrier (GO:0150201)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier.
negative regulation of transport across blood-brain barrier (GO:0150202)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier.
tuft (GO:0151001)
Namespace: cellular_component
Definition: A dense cluster of elongated, thick microvilli on the apical surface of tuft cells in epithelial tissues, such as the intestine and respiratory tract. The apical tuft extends further into the lumen than typical microvilli, featuring larger, more compact projections with unique actin cores that penetrate deep into the cytoplasm, often reaching the perinuclear region. This distinctive structure, rich in microfilaments and microtubules, supports the chemosensory functions of the cell.
extrasynaptic signaling via GABA (GO:0160001)
Namespace: biological_process
Definition: Cell-cell signaling that starts with the activation of extrasynaptic GABA receptors in neurons through binding of ambient gamma-aminobutyric acid present in the extracellular fluid.
ADP-D-ribose modification-dependent protein binding (GO:0160002)
Namespace: molecular_function
Definition: Binding to a protein upon ADP-ribosylation of the target protein.
Comment: This term should only be used when the binding is shown to require a ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
mono-ADP-D-ribose modification-dependent protein binding (GO:0160003)
Namespace: molecular_function
Definition: Binding to a protein upon mono-ADP-ribosylation of the target protein.
Comment: This term should only be used when the binding is shown to require a mono-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
PAT complex (GO:0160005)
Namespace: cellular_component
Definition: A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47.
Comment: PAT complex functions by shielding exposed hydrophilicity of transmembrane domains (TMDs) to prevent premature degradation and promote proper folding and bundling of TMDs.
Fc receptor-mediated immune complex endocytosis (GO:0160006)
Namespace: biological_process
Definition: An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I.
Synonyms: antigen-antibody immune complex uptake via Fc receptor; Fc receptor-mediated immune complex internalization; Ig-complexed antigen endocytosis via Fc receptor
glutathione import into mitochondrion (GO:0160007)
Namespace: biological_process
Definition: The process in which glutathione is transported from the cytosol into the mitochondrial matrix.
protein decrotonylase activity (GO:0160008)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein].
histone decrotonylase activity (GO:0160009)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone].
protein de-2-hydroxyisobutyrylase activity (GO:0160010)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein].
NAD-dependent protein decrotonylase activity (GO:0160011)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
histone decrotonylase activity, NAD-dependent (GO:0160012)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide.
Synonyms: NAD-dependent histone decrotonylase activity
NAD-dependent protein de-2-hydroxyisobutyrylase activity (GO:0160013)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
exopher (GO:0160014)
Namespace: cellular_component
Definition: An extracellular vesicle that is approximately four microns in diameter, released by budding out of cells into the extracellular space, and hypothesized to be a mechanism for disposal of unwanted cellular material including protein aggregates and damaged organelles.
platelet rolling (GO:0160015)
Namespace: biological_process
Definition: Transient adhesive interactions between platelets and endothelial cells lining blood vessels. Carbohydrates on circulating platelets bind selectins or other molecules on the vessel wall causing the platelets to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between surface molecules of platelets and endothelium.
CCACCA tRNA nucleotidyltransferase activity (GO:0160016)
Namespace: molecular_function
Definition: Catalysis of the reaction: a tRNA with a 3' CCA end + 2 CTP + ATP = a tRNA with a 3' CCACCA end + 3 diphosphate.
regulation of platelet rolling (GO:0160017)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of platelet rolling.
positive regulation of platelet rolling (GO:0160018)
Namespace: biological_process
Definition: Any process that increases the rate, frequency, or extent of platelet rolling.
negative regulation of platelet rolling (GO:0160019)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency, or extent of platelet rolling.
positive regulation of ferroptosis (GO:0160020)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of ferroptosis.
maternal-to-zygotic transition of gene expression (GO:0160021)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of gene expression by which developmental control passes from the maternal genome to the zygotic genome.
Synonyms: MZT
apocrine secretion (GO:0160022)
Namespace: biological_process
Definition: The controlled release of a substance by a cell or a tissue by discharging a portion of the secreting cell when intracellular components are freed into a lumen through the shedding of whole pieces of the cytoplasm.
Synonyms: secretion by cell decapitation; secretion by membrane budding