LiteFold/GO huggingface dataset:
obsolete kappa-opioid receptor activity (GO:0004987)
Namespace: molecular_function
Definition: OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins.
Synonyms: kappa-opioid receptor activity
Comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
octopamine receptor activity (GO:0004989)
Namespace: molecular_function
Definition: Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist.
parathyroid hormone receptor activity (GO:0004991)
Namespace: molecular_function
Definition: Combining with parathyroid hormone to initiate a change in cell activity.
platelet activating factor receptor activity (GO:0004992)
Namespace: molecular_function
Definition: Combining with platelet activating factor to initiate a change in cell activity.
Synonyms: PAF receptor activity
G protein-coupled serotonin receptor activity (GO:0004993)
Namespace: molecular_function
Definition: Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
Synonyms: 5-HT receptor; 5-hydroxytryptamine receptor; G protein coupled serotonin receptor activity; G-protein coupled serotonin receptor activity
somatostatin receptor activity (GO:0004994)
Namespace: molecular_function
Definition: Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).
Synonyms: GHIH receptor activity; growth hormone-inhibiting hormone receptor activity; somatotrophin release inhibiting factor receptor activity; SRIF receptor activity; SST receptor activity
tachykinin receptor activity (GO:0004995)
Namespace: molecular_function
Definition: Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein.
thyrotropin-releasing hormone receptor activity (GO:0004997)
Namespace: molecular_function
Definition: Combining with thyrotropin-releasing hormone to initiate a change in cell activity.
transferrin receptor activity (GO:0004998)
Namespace: molecular_function
Definition: Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.
vasoactive intestinal polypeptide receptor activity (GO:0004999)
Namespace: molecular_function
Definition: Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.
vasopressin receptor activity (GO:0005000)
Namespace: molecular_function
Definition: Combining with vasopressin to initiate a change in cell activity.
Synonyms: vasopressin activated calcium mobilizing receptor activity
transmembrane receptor protein tyrosine phosphatase activity (GO:0005001)
Namespace: molecular_function
Definition: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
ephrin receptor activity (GO:0005003)
Namespace: molecular_function
Definition: Combining with an ephrin receptor ligand to initiate a change in cell activity.
Synonyms: Eph receptor activity
GPI-linked ephrin receptor activity (GO:0005004)
Namespace: molecular_function
Definition: Combining with a GPI-anchored ephrin to initiate a change in cell activity.
Synonyms: GPI-linked Eph receptor activity
transmembrane-ephrin receptor activity (GO:0005005)
Namespace: molecular_function
Definition: Combining with a transmembrane ephrin to initiate a change in cell activity.
Synonyms: transmembrane-Eph receptor activity
epidermal growth factor receptor activity (GO:0005006)
Namespace: molecular_function
Definition: Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: EGF receptor activity; EGFR; epidermal growth factor-activated receptor activity; TGF-alpha receptor activity; transforming growth factor-alpha receptor activity
fibroblast growth factor receptor activity (GO:0005007)
Namespace: molecular_function
Definition: Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: FGF receptor activity; FGF-activated receptor activity; FGFR; fibroblast growth factor-activated receptor activity
Comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
hepatocyte growth factor receptor activity (GO:0005008)
Namespace: molecular_function
Definition: Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: hepatocyte growth factor-activated receptor activity; HGF receptor activity; HGF-activated receptor activity
Comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
insulin receptor activity (GO:0005009)
Namespace: molecular_function
Definition: Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: insulin-activated receptor activity
insulin-like growth factor receptor activity (GO:0005010)
Namespace: molecular_function
Definition: Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: IGF receptor activity; IGF-activated receptor activity; insulin-like growth factor-activated receptor activity
Comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
macrophage colony-stimulating factor receptor activity (GO:0005011)
Namespace: molecular_function
Definition: Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
Synonyms: CSF-1; Fms; M-CSF receptor activity; macrophage colony stimulating factor receptor activity
obsolete Neu/ErbB-2 receptor activity (GO:0005012)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: Neu/ErbB-2 receptor activity
Comment: This term was made obsolete because it represents a class of receptor rather than an activity.
obsolete neurotrophin TRK receptor activity (GO:0005013)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: neurotrophin TRK receptor activity
Comment: This term was made obsolete because it represents a gene product.
obsolete neurotrophin TRKA receptor activity (GO:0005014)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: neurotrophin TRKA receptor activity
Comment: This term was made obsolete because it represents a gene product.
obsolete neurotrophin TRKB receptor activity (GO:0005015)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: neurotrophin TRKB receptor activity
Comment: This term was made obsolete because it represents a gene product.
obsolete neurotrophin TRKC receptor activity (GO:0005016)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: neurotrophin TRKC receptor activity
Comment: This term was made obsolete because it represents a gene product.
platelet-derived growth factor receptor activity (GO:0005017)
Namespace: molecular_function
Definition: Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: PDGF receptor activity; PDGF-activated receptor activity; PDGFR activity; platelet-derived growth factor-activated receptor activity
Comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
platelet-derived growth factor beta-receptor activity (GO:0005019)
Namespace: molecular_function
Definition: Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.
Synonyms: betaPDGF receptor activity; PDGF beta-receptor activity
stem cell factor receptor activity (GO:0005020)
Namespace: molecular_function
Definition: Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
Synonyms: KIT; KIT ligand receptor activity; KL receptor activity; SCF receptor activity
vascular endothelial growth factor receptor activity (GO:0005021)
Namespace: molecular_function
Definition: Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Synonyms: vascular endothelial growth factor E-activated receptor activity; vascular endothelial growth factor-activated receptor activity; VEGF receptor activity; VEGF-A-activated receptor activity; VEGF-activated receptor activity; VEGF-B-activated receptor activity; VEGF-C-activated receptor activity; VEGF-D-activated receptor activity; VEGF-E-activated receptor activity; VEGFR activity
Comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
transforming growth factor beta receptor activity (GO:0005024)
Namespace: molecular_function
Definition: Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
Synonyms: TGF-beta receptor activity; TGFbeta receptor activity; TGFbeta-activated receptor activity; TGFbetaR; transforming growth factor beta-activated receptor activity
Comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
transforming growth factor beta receptor activity, type I (GO:0005025)
Namespace: molecular_function
Definition: Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.
Synonyms: transforming growth factor beta ligand binding to type I receptor; type I TGF-beta receptor activity; type I TGFbeta receptor activity; type I transforming growth factor beta receptor activity
obsolete NGF/TNF (6 C-domain) receptor activity (GO:0005027)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: NGF/TNF (6 C-domain) receptor activity
Comment: This term was made obsolete because it represents a protein family rather than a molecular function.
obsolete CD27 receptor activity (GO:0005029)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: CD27 receptor activity
Comment: This term was made obsolete because it describes the receptor type, and not an activity.
neurotrophin receptor activity (GO:0005030)
Namespace: molecular_function
Definition: Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity.
tumor necrosis factor receptor activity (GO:0005031)
Namespace: molecular_function
Definition: Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
Synonyms: NGF/TNF (6 C-domain) receptor activity; TNF receptor activity; TNF receptor activity, type I; TNF receptor activity, type II; tumor necrosis factor receptor activity, type I; tumor necrosis factor receptor activity, type II; tumor necrosis factor-activated receptor activity
osmosensor activity (GO:0005034)
Namespace: molecular_function
Definition: Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell.
death receptor activity (GO:0005035)
Namespace: molecular_function
Definition: Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.
Synonyms: apoptosis-activating receptor activity
obsolete death receptor adaptor protein activity (GO:0005037)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: death receptor adaptor protein activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
obsolete death receptor interacting protein activity (GO:0005038)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: death receptor interacting protein activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
low-density lipoprotein particle receptor activity (GO:0005041)
Namespace: molecular_function
Definition: Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
Synonyms: LDL receptor; LDLR activity; low-density lipoprotein receptor activity
netrin receptor activity (GO:0005042)
Namespace: molecular_function
Definition: Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
netrin receptor activity involved in chemorepulsion (GO:0005043)
Namespace: molecular_function
Definition: Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin.
Synonyms: netrin receptor activity involved in negative chemotaxis; repulsive netrin receptor activity
scavenger receptor activity (GO:0005044)
Namespace: molecular_function
Definition: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
Synonyms: macrophage receptor activity
Comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.
obsolete endoplasmic reticulum receptor activity (GO:0005045)
Namespace: molecular_function
Definition: OBSOLETE. A receptor in the endoplasmic reticulum.
Synonyms: endoplasmic reticulum receptor activity
Comment: This term was made obsolete because it represents cellular component and molecular function information.
KDEL sequence binding (GO:0005046)
Namespace: molecular_function
Definition: Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.
Synonyms: KDEL receptor activity
signal recognition particle binding (GO:0005047)
Namespace: molecular_function
Definition: Binding to a signal recognition particle.
Synonyms: docking protein; signal recognition particle receptor
Comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'.
nuclear export signal receptor activity (GO:0005049)
Namespace: molecular_function
Definition: Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
Synonyms: exportin activity; importin-alpha binding; importin-alpha export receptor activity; NES receptor
obsolete peroxisome receptor (GO:0005050)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: peroxisome receptor
Comment: This term was made obsolete because it describes a cellular component.
peroxisome matrix targeting signal-1 binding (GO:0005052)
Namespace: molecular_function
Definition: Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L.
Synonyms: peroxisomal targeting signal 1 (PTS1) binding; peroxisome targeting signal-1 binding; peroxisome targeting signal-1 receptor; PEX5; PTS1 binding; PTS1 receptor
peroxisome matrix targeting signal-2 binding (GO:0005053)
Namespace: molecular_function
Definition: Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).
Synonyms: peroxisomal targeting signal 2 (PTS2) binding; peroxisome targeting signal-2 binding; peroxisome targeting signal-2 receptor; PEX7; PTS2 binding; PTS2 receptor
obsolete peroxisome integral membrane receptor (GO:0005054)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: Pas20p; peroxisome integral membrane receptor
Comment: This term was made obsolete because it describes a cellular component.
laminin receptor activity (GO:0005055)
Namespace: molecular_function
Definition: Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
tiggrin receptor activity (GO:0005056)
Namespace: molecular_function
Definition: Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
obsolete signal transducer activity, downstream of receptor (GO:0005057)
Namespace: molecular_function
Definition: OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.
Synonyms: intracellular signal transducer activity; receptor signaling protein activity; receptor signalling protein activity
Comment: This term was obsoleted because it was not clearly defined.
obsolete aryl hydrocarbon receptor nuclear translocator activity (GO:0005061)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: aryl hydrocarbon receptor nuclear translocator activity
Comment: This term was made obsolete because it represents a gene product.
obsolete heterotrimeric G-protein (GO:0005065)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: heterotrimeric G-protein
Comment: This term was made obsolete because it represents a cellular component and not a molecular function.
obsolete transmembrane receptor protein tyrosine kinase signaling protein activity (GO:0005066)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: transmembrane receptor protein tyrosine kinase signaling protein activity; transmembrane receptor protein tyrosine kinase signalling protein activity
Comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
Synonyms: transmembrane receptor protein tyrosine kinase adaptor protein activity; transmembrane receptor protein tyrosine kinase docking protein activity
obsolete SH3/SH2 adaptor activity (GO:0005070)
Namespace: molecular_function
Definition: OBSOLETE. Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
Synonyms: SH3/SH2 adaptor protein activity
Comment: This term was obsoleted because molecular adaptors should be represented by the type of molecules they serve to adapt, and not by their domains.
obsolete transforming growth factor beta receptor, cytoplasmic mediator activity (GO:0005072)
Namespace: molecular_function
Definition: OBSOLETE. Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus.
Synonyms: TGF-beta receptor, cytoplasmic mediator activity; TGFbeta receptor, cytoplasmic mediator activity
Comment: This term was obsoleted because it is redundant with other terms.
obsolete common-partner SMAD protein (GO:0005073)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: common-partner SMAD protein
Comment: This term was made obsolete because it names a family of gene products.
obsolete inhibitory SMAD protein (GO:0005074)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: inhibitory SMAD protein
Comment: This term was made obsolete because it names a family of gene products.