LiteFold/GO huggingface dataset:
amyloid-beta complex (GO:0106003)
Namespace: cellular_component
Definition: Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease.
Synonyms: Abeta complex; Abeta-derived diffusible ligand complex; ADDL complex; amyloid beta complex; amyloid beta dimer; amyloid beta heterodimer; amyloid beta heterooligomer; amyloid beta heterotrimer; amyloid beta homodimer; amyloid beta homooligomer; amyloid beta homotrimer; amyloid beta oligomer; amyloid beta trimer; amyloid-beta protein 40 complex; amyloid-beta protein 40/42 complex; amyloid-beta protein 42 complex; beta amyloid complex; beta-amyloid complex; betaA complex; heterodimer of amyloid beta protein; heterooligomer of amyloid beta protein; heterotrimer of amyloid beta protein; homodimer of amyloid beta protein; homooligomer of amyloid beta protein; homotrimer of amyloid beta protein
Comment: An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay).
tRNA (guanine-N7)-methylation (GO:0106004)
Namespace: biological_process
Definition: The process whereby a guanine in a tRNA is methylated at the N7 position of guanine.
RNA 5'-cap (guanine-N7)-methylation (GO:0106005)
Namespace: biological_process
Definition: The process whereby a guanine in 5-cap is methylated at the N7 position of guanine.
cytoskeletal protein-membrane anchor activity (GO:0106006)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location.
Synonyms: BAR domain adaptor; cytoskeletal protein membrane adaptor; cytoskeletal protein membrane anchor activity; cytoskeletal protein membrane tether activity; cytoskeletal protein to membrane recruiting activity; cytoskeletal protein-membrane adaptor activity; F-BAR domain adaptor; membrane-cytoskeletal protein anchor activity; membrane-cytoskeletal protein tether activity; microtubule cortical anchor activity
microtubule anchoring at cell cortex of cell tip (GO:0106007)
Namespace: biological_process
Definition: Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex.
regulation of protein localization to medial cortex (GO:0106011)
Namespace: biological_process
Definition: Any process that regulates the localization of a protein to the medial cortex.
positive regulation of protein localization to medial cortex (GO:0106012)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex.
negative regulation of protein localization to cell cortex of cell tip (GO:0106013)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip.
regulation of inflammatory response to wounding (GO:0106014)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the inflammatory response to wounding.
negative regulation of inflammatory response to wounding (GO:0106015)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding.
positive regulation of inflammatory response to wounding (GO:0106016)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding.
phosphatidylinositol-3,4-bisphosphate phosphatase activity (GO:0106017)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
phosphatidylinositol-3,5-bisphosphate phosphatase activity (GO:0106018)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
phosphatidylinositol-4,5-bisphosphate phosphatase activity (GO:0106019)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
regulation of vesicle docking (GO:0106020)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of vesicle docking.
Synonyms: regulation of vesicle to membrane docking
negative regulation of vesicle docking (GO:0106021)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking.
Synonyms: negative regulation of vesicle to membrane docking
positive regulation of vesicle docking (GO:0106022)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of vesicle docking.
Synonyms: positive regulation of vesicle to membrane docking
regulation of pupariation (GO:0106023)
Namespace: biological_process
Definition: Any process that modulates the onset of pupariation.
negative regulation of pupariation (GO:0106024)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate of onset of pupariation.
positive regulation of pupariation (GO:0106025)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of onset of pupariation.
Gly-tRNA(Ala) deacylase activity (GO:0106026)
Namespace: molecular_function
Definition: Catalysis of the reaction: glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H+.
neuron projection organization (GO:0106027)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite.
neuron projection retraction (GO:0106028)
Namespace: biological_process
Definition: The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
Synonyms: neuron projection disassembly
tRNA pseudouridine synthase activity (GO:0106029)
Namespace: molecular_function
Definition: Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
Synonyms: transfer ribonucleate pseudouridine synthetase activity; transfer RNA pseudouridine synthetase activity; tRNA-pseudouridine synthase activity; tRNA-uridine isomerase activity; tRNA-uridine uracilmutase activity
neuron projection fasciculation (GO:0106030)
Namespace: biological_process
Definition: The collection of neuronal projections into a bundle of rods, known as a fascicle.
snRNA pseudouridine synthase activity (GO:0106032)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine in snRNA = pseudouridine in snRNA. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
obsolete protein maturation by [2Fe-2S] cluster transfer (GO:0106034)
Namespace: biological_process
Definition: OBSOLETE. The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
Comment: The reason for obsoletion is that these BP terms represent MFs.
obsolete protein maturation by [4Fe-4S] cluster transfer (GO:0106035)
Namespace: biological_process
Definition: OBSOLETE. The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
Comment: The reason for obsoletion is that these BP terms represent MFs.
assembly of apicomedial cortex actomyosin (GO:0106036)
Namespace: biological_process
Definition: A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin.
apicomedial cortex (GO:0106037)
Namespace: cellular_component
Definition: The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell.
Synonyms: medioapical cortex
obsolete vesicle assembly (GO:0106038)
Namespace: biological_process
Definition: OBSOLETE. A process carried out at the cellular level, which results in the arrangement of constituent parts of a vesicle. Vesicle assembly begins with membrane bending (GO:0097753) and ends with fusion of the vesicle after vesicle scission (GO:0099050).
Synonyms: vesicle biosynthesis; vesicle formation
Comment: This term was made obsolete because it is an exact synonym of 'membrane budding'.
obsolete vesicle fusion involved in vesicle assembly (GO:0106039)
Namespace: biological_process
Definition: OBSOLETE. A process carried out at the cellular level, which is the final step in vesicle assembly. Vesicle fusion occurs when a newly assembled vesicle closes up, following vesicle vesicle scission (GO:0099050).
Comment: This term was made obsolete becausethat 'fusion' should only be used for two membranes getting joined together, whereas in this case it would be one membrane 'closing/sealing up'.
regulation of GABA-A receptor activity (GO:0106040)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of GABA-A receptor activity.
obsolete positive regulation of GABA-A receptor activity (GO:0106041)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of GABA-A receptor activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete negative regulation of GABA-A receptor activity (GO:0106042)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity.
Comment: This term was obsoleted because it represents a molecular function.
guanine deglycation (GO:0106044)
Namespace: biological_process
Definition: The removal of a sugar or dicarbonyl from a glycated guanine.
obsolete guanine deglycation, methylglyoxal removal (GO:0106045)
Namespace: biological_process
Definition: OBSOLETE. The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine.
Comment: The reason for obsoletion is that this term represents a molecular function rather than a biological process.
polyamine deacetylation (GO:0106047)
Namespace: biological_process
Definition: The modification of acetylpolyamine by the removal of acetyl groups.
regulation of cellular response to osmotic stress (GO:0106049)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress.
obsolete tRNA 2'-O-methyltransferase activity (GO:0106050)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide.
Comment: This term was obsoleted because it is an unnecessray grouping term.
obsolete tRNA-uracil-34 sulfurtransferase activity (GO:0106054)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+.
Synonyms: tRNA U34 2-thiouridylase; tRNA U34 thiol-transferase activity; tRNA-specific 2-thiouridylase
Comment: The reason for obsoletion is that this term is equivalent to GO:0103016 tRNA-uridine 2-sulfurtransferase activity.
mannosyl-oligosaccharide 1,2-alpha-mannosidase complex (GO:0106055)
Namespace: cellular_component
Definition: A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.
Comment: An example is MNL1 (P38888) in Saccharomyces cerevisiae. PMID:19124653 (by physical interaction evidence).
regulation of calcineurin-mediated signaling (GO:0106056)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling.
negative regulation of calcineurin-mediated signaling (GO:0106057)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling.
positive regulation of calcineurin-mediated signaling (GO:0106058)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling.
tRNA (cytidine(56)-2'-O-ribose)-methyltransferase activity (GO:0106059)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA.
Synonyms: tRNA (cytidine 56-2'-O)-methyltransferase activity; tRNA (cytidine(56)-2'-O)-methyltransferase activity
negative regulation of exit from meiosis (GO:0106061)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis.
G protein-coupled folate receptor activity (GO:0106063)
Namespace: molecular_function
Definition: Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity.
Synonyms: G-protein coupled folate receptor activity; G-protein coupled folic acid receptor activity
regulation of cobalamin metabolic process (GO:0106064)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
SUMO ligase complex (GO:0106068)
Namespace: cellular_component
Definition: A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex.
Synonyms: SUMO transferase complex; SUMO-protein ligase complex; Sumoylation complex
synapsis initiation complex (GO:0106069)
Namespace: cellular_component
Definition: A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase.
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0106070)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
Synonyms: regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0106071)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
Synonyms: positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0106072)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
Synonyms: negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity (GO:0106073)
Namespace: molecular_function
Definition: Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
aminoacyl-tRNA metabolism involved in translational fidelity (GO:0106074)
Namespace: biological_process
Definition: Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation.
Synonyms: aminoacyl-tRNA correction; aminoacyl-tRNA editin; aminoacyl-tRNA proofreading
peptide N-succinyltransferase activity (GO:0106075)
Namespace: molecular_function
Definition: Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide.
peptide-lysine-N-succinyltransferase activity (GO:0106076)
Namespace: molecular_function
Definition: Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide.
obsolete histone succinylation (GO:0106077)
Namespace: biological_process
Definition: OBSOLETE. The modification of a histone by the addition of an succinyl group.
Comment: The reason for obsoletion is that this term represents a Molecular Function.
histone succinyltransferase activity (GO:0106078)
Namespace: molecular_function
Definition: Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone.
GATOR1 complex binding (GO:0106080)
Namespace: molecular_function
Definition: Binding to a GATOR1 complex.
maltose import across plasma membrane (GO:0106081)
Namespace: biological_process
Definition: The directed movement of maltose from outside of a cell, across the plasma membrane and into the cytosol.
sucrose import across plasma membrane (GO:0106082)
Namespace: biological_process
Definition: The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol.
nuclear membrane protein complex (GO:0106083)
Namespace: cellular_component
Definition: Any protein complex that is part of the nuclear membrane.
mitotic nuclear membrane microtubule tethering complex (GO:0106084)
Namespace: cellular_component
Definition: A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane.
Synonyms: Mps2-Bbp1-Spc29 complex; nuclear membrane mitotic spindle pole body tethering complex
Comment: In S. cerevisae Mps2-Bpb1 is the membrane anchor sub complex and Spc29 is the spindle pole body linker molecule.
obsolete regulation of cell adhesion involved in sprouting angiogenesis (GO:0106088)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
negative regulation of cell adhesion involved in sprouting angiogenesis (GO:0106089)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis.
obsolete glial cell projection elongation involved in axon ensheathment (GO:0106092)
Namespace: biological_process
Definition: OBSOLETE. The extension of a glial cell process or projection to wrap around an axon.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
EDS1 disease-resistance complex (GO:0106093)
Namespace: cellular_component
Definition: A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes.
Synonyms: EDS1-PAD4 complex; EDS1-PAD4-SAG101 complex; EDS1-SAG101 complex
Comment: Interacts with the R genes triggering ETI and systemic resistance.
nuclear membrane microtubule tethering complex (GO:0106094)
Namespace: cellular_component
Definition: A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules.
m7G(5')pppN diphosphatase complex (GO:0106095)
Namespace: cellular_component
Definition: A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide.
Synonyms: 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase enzyme; DCS1 decapping scavenger complex; M(7)G(5')pppN pyrophosphatase enzyme; m7G(5')pppN diphosphatase enzyme; m7G(5')pppN pyrophosphatase enzyme
response to ceramide (GO:0106096)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus.
cellular response to ceramide (GO:0106097)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus.
NAGS/NAGK complex (GO:0106098)
Namespace: cellular_component
Definition: A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate.
2-keto-3-deoxy-L-rhamnonate aldolase activity (GO:0106099)
Namespace: molecular_function
Definition: Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde.
beta-pinacene synthase activity (GO:0106100)
Namespace: molecular_function
Definition: Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate.
ER-dependent peroxisome localization (GO:0106101)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum.
COPII vesicles tethering complex (GO:0106103)
Namespace: cellular_component
Definition: A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae.
Synonyms: Bug1-Grh1 complex; GRASP65-GM130 complex
regulation of glutamate receptor clustering (GO:0106104)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of glutamate receptor clustering.
Ala-tRNA(Thr) deacylase activity (GO:0106105)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-alanyl-tRNA(Thr) + H2O = tRNA(Thr) + L-alanine + H+.
Synonyms: L-alanyl-tRNA(Thr) deacylase