LiteFold/GO huggingface dataset:
minus-end-directed microtubule motor activity (GO:0008569)
Namespace: molecular_function
Definition: A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.
Synonyms: ATP-dependent microtubule motor activity, minus-end-directed; ATP-dependent minus-end-directed microtubule motor activity; dynein ATPase; kinesin ATP phosphohydrolase (minus-end-directed); microtubule motor activity, minus-end-directed; minus-end-directed ATP-dependent microtubule motor activity; minus-end-directed kinesin ATPase activity
obsolete non-chaperonin molecular chaperone ATPase activity (GO:0008571)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin.
Synonyms: non-chaperonin molecular chaperone ATPase activity
Comment: This term was made obsolete because it represents a class of gene products.
obsolete nucleoplasmin ATPase activity (GO:0008572)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes.
Synonyms: nucleoplasmin ATPase activity
Comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
obsolete peroxisome-assembly ATPase activity (GO:0008573)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle.
Synonyms: peroxisome-assembly ATPase activity
Comment: This term was made obsolete because it incorporates process information.
plus-end-directed microtubule motor activity (GO:0008574)
Namespace: molecular_function
Definition: A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.
Synonyms: ATP-dependent microtubule motor activity, plus-end-directed; ATP-dependent plus-end-directed microtubule motor activity; kinesin activity; kinesin ATP phosphohydrolase (plus-end-directed); microtubule motor activity, plus-end-directed; plus-end-directed ATP-dependent microtubule motor activity; plus-end-directed kinesin ATPase activity
obsolete vesicle-fusing ATPase activity (GO:0008576)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
Synonyms: vesicle-fusing ATPase activity
Comment: This term was made obsolete because it incorporates process information.
JUN kinase phosphatase activity (GO:0008579)
Namespace: molecular_function
Definition: Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.
obsolete cytoskeletal regulator activity (GO:0008580)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: cytoskeletal regulator activity
Comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology.
obsolete ubiquitin-specific protease 5 activity (GO:0008581)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin.
Synonyms: ubiquitin isopeptidase T activity; ubiquitin-specific protease 5 activity
Comment: This term was made obsolete because it represents a gene product.
regulation of synaptic assembly at neuromuscular junction (GO:0008582)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.
Synonyms: regulation of synaptic growth at neuromuscular junction
mystery cell differentiation (GO:0008583)
Namespace: biological_process
Definition: The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster.
male gonad development (GO:0008584)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
Synonyms: testicular development; testis development
female gonad development (GO:0008585)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
Synonyms: ovarian development; ovary development
imaginal disc-derived wing vein morphogenesis (GO:0008586)
Namespace: biological_process
Definition: The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.
Synonyms: wing vein morphogenesis
imaginal disc-derived wing margin morphogenesis (GO:0008587)
Namespace: biological_process
Definition: The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade.
Synonyms: wing margin morphogenesis
Comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'.
regulation of smoothened signaling pathway (GO:0008589)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of smoothened signaling.
Synonyms: regulation of hedgehog signaling pathway; regulation of hh signaling pathway; regulation of smoothened activity; regulation of smoothened by patched; regulation of smoothened receptor activity by patched; regulation of smoothened signalling pathway
regulation of Wnt signaling pathway, calcium modulating pathway (GO:0008591)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
Synonyms: regulation of frizzled-2 signaling pathway; regulation of frizzled-2 signalling pathway; regulation of Wnt receptor signaling pathway, calcium modulating pathway; regulation of Wnt-activated signaling pathway, calcium modulating pathway
regulation of Toll signaling pathway (GO:0008592)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the Tl signaling pathway.
Synonyms: regulation of Tl signaling pathway; regulation of Tl signalling pathway; regulation of Toll signalling pathway
regulation of Notch signaling pathway (GO:0008593)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
Synonyms: regulation of N signaling pathway; regulation of N signalling pathway; regulation of Notch signalling pathway
photoreceptor cell morphogenesis (GO:0008594)
Namespace: biological_process
Definition: The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.
Synonyms: photoreceptor development
anterior/posterior axis specification, embryo (GO:0008595)
Namespace: biological_process
Definition: The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.
Synonyms: anterior/posterior axis determination, embryo
calcium-dependent protein serine/threonine phosphatase regulator activity (GO:0008597)
Namespace: molecular_function
Definition: Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.
Synonyms: calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity
obsolete protein kinase CK2 regulator activity (GO:0008605)
Namespace: molecular_function
Definition: OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2.
Synonyms: casein kinase II, regulator; protein kinase CK2 regulator activity; protein kinase CK2, intrinsic regulator activity
Comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
phosphorylase kinase regulator activity (GO:0008607)
Namespace: molecular_function
Definition: Modulation of the activity of the enzyme phosphorylase kinase.
Synonyms: phosphorylase kinase, intrinsic regulator activity
attachment of spindle microtubules to kinetochore (GO:0008608)
Namespace: biological_process
Definition: The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
Synonyms: amphotelic attachment; attachment of spindle microtubules to chromosome; bipolar attachment; kinetochore microtubule interaction; kinetochore-microtubule attachment; kinetochore-microtubule interaction; microtubule anchoring at kinetochore; microtubule and chromosome interaction; microtubule and kinetochore interaction; microtubule capture; spindle chromosome attachment; spindle kinetochore attachment; spindle-chromosome interaction
Comment: This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
alkylglycerone-phosphate synthase activity (GO:0008609)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.
Synonyms: 1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity; alkyl DHAP synthetase activity; alkyl-DHAP; alkyl-DHAP synthase activity; alkyldihydroxyacetone phosphate synthetase activity; alkyldihydroxyacetonephosphate synthase activity; DHAP-AT; dihydroxyacetone-phosphate acyltransferase activity
lipid biosynthetic process (GO:0008610)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
Synonyms: lipid anabolism; lipid biosynthesis; lipid formation; lipid synthesis; lipogenesis
ether lipid biosynthetic process (GO:0008611)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
Synonyms: ether lipid anabolism; ether lipid biosynthesis; ether lipid formation; ether lipid synthesis; plasmalogen biosynthetic process
peptidyl-hypusine biosynthetic process (GO:0008612)
Namespace: biological_process
Definition: The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine, an unusual amino acid synthesized post-translationally.
Synonyms: hypusine anabolism; hypusine anabolism from peptidyl-lysine; hypusine biosynthesis; hypusine biosynthetic process; hypusine biosynthetic process from peptidyl-lysine; hypusine formation; hypusine formation from peptidyl-lysine; hypusine synthesis; hypusine synthesis from peptidyl-lysine; hypusinylation; protein hypusination
pyridoxine metabolic process (GO:0008614)
Namespace: biological_process
Definition: The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
Synonyms: pyridoxine metabolism
pyridoxine biosynthetic process (GO:0008615)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.
Synonyms: pyridoxine anabolism; pyridoxine biosynthesis; pyridoxine formation; pyridoxine synthesis
tRNA queuosine(34) biosynthetic process (GO:0008616)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence  (position 34) corresponds to the first position of the anticodon.
Synonyms: queuosine anabolism; queuosine biosynthesis; queuosine biosynthetic process; queuosine formation; queuosine synthesis
guanosine metabolic process (GO:0008617)
Namespace: biological_process
Definition: The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution.
Synonyms: guanosine metabolism
7-methylguanosine metabolic process (GO:0008618)
Namespace: biological_process
Definition: The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA.
Synonyms: 7-methylguanosine metabolism
obsolete RHEB small monomeric GTPase activity (GO:0008619)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Synonyms: RHEB small monomeric GTPase activity
Comment: This term was made obsolete because it represents a gene product.
epsilon DNA polymerase complex (GO:0008622)
Namespace: cellular_component
Definition: A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
Synonyms: DNA polymerase epsilon complex
CHRAC (GO:0008623)
Namespace: cellular_component
Definition: An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair.
Synonyms: chromatin accessibility complex; ISW2 complex
extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)
Namespace: biological_process
Definition: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
Synonyms: death receptor-mediated apoptosis; induction of apoptosis via death domain receptors; induction of apoptosis via death receptors
Comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
granzyme-mediated apoptotic signaling pathway (GO:0008626)
Namespace: biological_process
Definition: The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
Synonyms: apoptotic signaling pathway in response to granzyme; induction of apoptosis by granzyme
intrinsic apoptotic signaling pathway in response to osmotic stress (GO:0008627)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.
Synonyms: induction of apoptosis by ionic changes
hormone-mediated apoptotic signaling pathway (GO:0008628)
Namespace: biological_process
Definition: The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered.
Synonyms: apoptotic signaling pathway in response to hormone; induction of apoptosis by hormones
Comment: This term is placed under GO:0097190 apoptotic signaling pathway, rather than under one of its more specific children terms, to cover for the variety of apoptosis signaling mechanisms that different hormones may use.
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Synonyms: DNA damage response, signal transduction resulting in induction of apoptosis
intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)
Namespace: biological_process
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
Synonyms: induction of apoptosis by oxidative stress; oxidative stress-induced intrinsic apoptotic signaling pathway
obsolete activation of pro-apoptotic gene products (GO:0008633)
Namespace: biological_process
Definition: OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form.
Synonyms: activation of pro-apoptotic gene products; induction of pro-apoptotic gene products
Comment: This term was made obsolete because more specific terms were created. Additionally, the meaning of the term is ambiguous (some gene products may be involved in apoptosis, or not, depending on cell type, tissue, condition).
obsolete negative regulation of survival gene product expression (GO:0008634)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.
Synonyms: down regulation of survival gene product activity; down-regulation of survival gene product activity; downregulation of survival gene product activity; inhibition of survival gene product activity; negative regulation of survival gene product activity; negative regulation of survival gene product expression; negative regulation of survival gene products
Comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc.
obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO:0008635)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c.
Synonyms: activation of caspase activity by cytochrome c; caspase activation via cytochrome c
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
obsolete activation of caspase activity by protein phosphorylation (GO:0008636)
Namespace: biological_process
Definition: OBSOLETE. Upregulation of the activity of a caspase, a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group.
Synonyms: activation of caspase activity by protein amino acid phosphorylation; activation of caspase activity by protein phosphorylation; caspase activation via phosphorylation
Comment: This term was made obsolete because it is ill-defined: phosphorylation regulates the activity of caspases, but it doesn't activate them (caspases are only activated upon cleavage).
apoptotic mitochondrial changes (GO:0008637)
Namespace: biological_process
Definition: The morphological and physiological alterations undergone by mitochondria during apoptosis.
Comment: This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.
ubiquitin-like modifier activating enzyme activity (GO:0008641)
Namespace: molecular_function
Definition: Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.
Synonyms: small protein activating enzyme activity
carbohydrate transport (GO:0008643)
Namespace: biological_process
Definition: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
Synonyms: sugar transport
obsolete tachykinin (GO:0008648)
Namespace: molecular_function
Definition: OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation.
Synonyms: tachykinin
Comment: This term was made obsolete because it represents a gene product.
obsolete actin polymerizing activity (GO:0008651)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: actin polymerizing activity
Comment: This term was made obsolete because it represents a biological process.
amino acid biosynthetic process (GO:0008652)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
Synonyms: amino acid anabolism; amino acid biosynthesis; amino acid formation; amino acid synthesis; cellular amino acid biosynthetic process