LiteFold/GO huggingface dataset:
negative regulation of Wnt signaling pathway (GO:0030178)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
Synonyms: down regulation of frizzled signaling pathway; down regulation of Wnt receptor signaling pathway; down-regulation of frizzled signaling pathway; down-regulation of Wnt receptor signaling pathway; downregulation of frizzled signaling pathway; downregulation of Wnt receptor signaling pathway; inhibition of frizzled signaling pathway; inhibition of Wnt receptor signaling pathway; negative regulation of frizzled signaling pathway; negative regulation of frizzled signalling pathway; negative regulation of Wnt receptor signaling pathway; negative regulation of Wnt receptor signalling pathway; negative regulation of Wnt-activated signaling pathway
obsolete solute:solute exchange (GO:0030180)
Namespace: biological_process
Definition: OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction.
Synonyms: solute:solute exchange
Comment: This term was made obsolete because it represents a molecular function.
obsolete sodium:calcium exchange (GO:0030181)
Namespace: biological_process
Definition: OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell.
Synonyms: sodium:calcium exchange
Comment: This term was made obsolete because it represents a function rather than a process.
neuron differentiation (GO:0030182)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a neuron.
B cell differentiation (GO:0030183)
Namespace: biological_process
Definition: The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
Synonyms: B cell development; B lymphocyte differentiation; B-cell differentiation; B-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
nitric oxide transmembrane transporter activity (GO:0030184)
Namespace: molecular_function
Definition: Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other.
nitric oxide transport (GO:0030185)
Namespace: biological_process
Definition: The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
melatonin metabolic process (GO:0030186)
Namespace: biological_process
Definition: The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine).
Synonyms: melatonin metabolism
melatonin biosynthetic process (GO:0030187)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine).
Synonyms: melatonin anabolism; melatonin biosynthesis; melatonin formation; melatonin synthesis
obsolete chaperone regulator activity (GO:0030188)
Namespace: molecular_function
Definition: OBSOLETE. Modulates the activity of a molecular chaperone.
Synonyms: chaperone regulator activity
Comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
obsolete chaperone activator activity (GO:0030189)
Namespace: molecular_function
Definition: OBSOLETE. Increases the activity of a molecular chaperone.
Synonyms: chaperone activator activity
Comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
obsolete chaperone inhibitor activity (GO:0030190)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone.
Synonyms: chaperone inhibitor activity
Comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
obsolete Hsp70/Hsc70 protein inhibitor activity (GO:0030191)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class.
Synonyms: Hsp70/Hsc70 protein inhibitor activity
Comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
obsolete Hsp70/Hsc70 protein regulator activity (GO:0030192)
Namespace: molecular_function
Definition: OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class.
Synonyms: Hsp70/Hsc70 protein regulator activity
Comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
regulation of blood coagulation (GO:0030193)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of blood coagulation.
positive regulation of blood coagulation (GO:0030194)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of blood coagulation.
Synonyms: activation of blood coagulation; stimulation of blood coagulation; up regulation of blood coagulation; up-regulation of blood coagulation; upregulation of blood coagulation
negative regulation of blood coagulation (GO:0030195)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
Synonyms: down regulation of blood coagulation; down-regulation of blood coagulation; downregulation of blood coagulation; inhibition of blood coagulation
cyanide hydratase activity (GO:0030196)
Namespace: molecular_function
Definition: Catalysis of the reaction: formamide = H2O + hydrogen cyanide.
Synonyms: formamide dehydratase activity; formamide hydro-lyase (cyanide-forming); formamide hydro-lyase activity
extracellular matrix constituent, lubricant activity (GO:0030197)
Namespace: molecular_function
Definition: Functions as a lubricant for an extracellular matrix, such as a mucous membrane.
Synonyms: core extracellular matrix; core matrisome
Comment: Extracellular matrix mucin proteins may be annotated to this term. PMID:14711375, PMID:18601586
extracellular matrix organization (GO:0030198)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
Synonyms: extracellular matrix organisation; extracellular matrix organization and biogenesis
collagen fibril organization (GO:0030199)
Namespace: biological_process
Definition: Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.
Synonyms: collagen fibril organisation; fibrillar collagen organization
heparan sulfate proteoglycan catabolic process (GO:0030200)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids.
Synonyms: heparan sulfate proteoglycan breakdown; heparan sulfate proteoglycan catabolism; heparan sulfate proteoglycan degradation; heparan sulphate proteoglycan catabolic process; heparan sulphate proteoglycan catabolism; heparin proteoglycan catabolic process
heparan sulfate proteoglycan metabolic process (GO:0030201)
Namespace: biological_process
Definition: The chemical reactions and pathways involving heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids.
Synonyms: heparan sulfate proteoglycan metabolism; heparan sulphate proteoglycan metabolic process; heparan sulphate proteoglycan metabolism; heparin proteoglycan metabolic process
heparin proteoglycan metabolic process (GO:0030202)
Namespace: biological_process
Definition: The chemical reactions and pathways involving heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin proteoglycans are stored selectively in the secretory granules of mammalian mast cells.
Synonyms: heparan sulfate metabolic process; heparin metabolism
glycosaminoglycan metabolic process (GO:0030203)
Namespace: biological_process
Definition: The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units.
Synonyms: glycosaminoglycan metabolism
obsolete chondroitin sulfate metabolic process (GO:0030204)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
Synonyms: chondroitin sulfate metabolism; chondroitin sulphate metabolic process; chondroitin sulphate metabolism
Comment: This term was obsoleted because chondroitin sulfate is always part of a proteoglycan, so this term represents the same pathway as chondroitin sulfate proteoglycan metabolic process ; GO:0050654.
obsolete dermatan sulfate metabolic process (GO:0030205)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.
Synonyms: chondroitin sulfate B metabolic process; chondroitin sulfate B metabolism; dermatan sulfate metabolism; dermatan sulphate metabolic process; dermatan sulphate metabolism
Comment: This term was obsoleted because dematan sulfate is always part of a proteoglycan, so this term represents the same process as dermatan sulfate proteoglycan metabolic process ; GO:0050655.
obsolete chondroitin sulfate biosynthetic process (GO:0030206)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
Synonyms: chondroitin sulfate anabolism; chondroitin sulfate biosynthesis; chondroitin sulfate formation; chondroitin sulfate synthesis; chondroitin sulphate biosynthesis; chondroitin sulphate biosynthetic process
Comment: This term was obsoleted because chondroitin sulfate is always part of a proteoglycan, so this term represents the same pathway as chondroitin sulfate proteoglycan biosynthetic process ; GO:0050650.
chondroitin sulfate proteoglycan catabolic process (GO:0030207)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate proteoglycans, which consist of a core protein linked to a chondroitin sulfate glycosaminoglycan. The chondroitin sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-glucuronic acid-beta-(1,3)-N-acetyl-D-galactosamine, the latter of which can be O-sulfated.
Synonyms: chondroitin sulfate breakdown; chondroitin sulfate catabolism; chondroitin sulfate degradation; chondroitin sulphate catabolic process; chondroitin sulphate catabolism
obsolete dermatan sulfate biosynthetic process (GO:0030208)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.
Synonyms: chondroitin sulfate B biosynthesis; chondroitin sulfate B biosynthetic process; dermatan sulfate anabolism; dermatan sulfate biosynthesis; dermatan sulfate formation; dermatan sulfate synthesis; dermatan sulphate biosynthesis; dermatan sulphate biosynthetic process
Comment: This term was obsoleted because dematan sulfate is always part of a proteoglycan, so this term represents the same process as dermatan sulfate proteoglycan biosynthetic process ; GO:0050651.
dermatan sulfate proteoglycan catabolic process (GO:0030209)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of dermatan sulfate proteoglycans, which consist of a core protein linked to a dermatan sulfate glycosaminoglycan. The dermatan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-hexuronic acid-beta-(1,3)-N-acetyl-D-galactosamine. The former can be a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids and the latter can be O-sulfated.
Synonyms: chondroitin sulfate B catabolic process; chondroitin sulfate B catabolism; dermatan sulfate breakdown; dermatan sulfate catabolism; dermatan sulfate degradation; dermatan sulphate catabolic process; dermatan sulphate catabolism
heparin proteoglycan biosynthetic process (GO:0030210)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
Synonyms: heparan sulfate biosynthetic process; heparin anabolism; heparin biosynthesis; heparin formation; heparin synthesis
heparin proteoglycan catabolic process (GO:0030211)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups.
Synonyms: heparan sulfate catabolic process; heparin breakdown; heparin catabolism; heparin degradation
hyaluronan metabolic process (GO:0030212)
Namespace: biological_process
Definition: The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine.
Synonyms: hyaluronan metabolism
hyaluronan biosynthetic process (GO:0030213)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine.
Synonyms: hyaluronan anabolism; hyaluronan biosynthesis; hyaluronan formation; hyaluronan synthesis
hyaluronan catabolic process (GO:0030214)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine.
Synonyms: hyaluronan breakdown; hyaluronan catabolism; hyaluronan degradation
semaphorin receptor binding (GO:0030215)
Namespace: molecular_function
Definition: Binding to a semaphorin receptor.
Synonyms: plexin binding; plexin ligand; semaphorin receptor ligand
keratinocyte differentiation (GO:0030216)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
Synonyms: keratinocyte cell differentiation
T cell differentiation (GO:0030217)
Namespace: biological_process
Definition: The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
Synonyms: T cell development; T lymphocyte differentiation; T-cell differentiation; T-lymphocyte differentiation
Comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
erythrocyte differentiation (GO:0030218)
Namespace: biological_process
Definition: The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
Synonyms: erythrocyte cell differentiation; erythropoiesis; RBC differentiation; red blood cell differentiation
megakaryocyte differentiation (GO:0030219)
Namespace: biological_process
Definition: The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
Synonyms: megakaryocyte cell differentiation
platelet formation (GO:0030220)
Namespace: biological_process
Definition: The process in which platelets bud from long processes extended by megakaryocytes.
Synonyms: platelet extrusion
basophil differentiation (GO:0030221)
Namespace: biological_process
Definition: The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.
Synonyms: basophil cell differentiation
eosinophil differentiation (GO:0030222)
Namespace: biological_process
Definition: The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil.
Synonyms: eosinophil cell development; eosinophil cell differentiation; eosinophil development
monocyte differentiation (GO:0030224)
Namespace: biological_process
Definition: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.
Synonyms: monocyte cell differentiation
macrophage differentiation (GO:0030225)
Namespace: biological_process
Definition: The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
Synonyms: macrophage cell differentiation
apolipoprotein receptor activity (GO:0030226)
Namespace: molecular_function
Definition: Combining with an apolipoprotein to initiate a change in cell activity.
obsolete apolipoprotein E receptor activity (GO:0030227)
Namespace: molecular_function
Definition: OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity.
Synonyms: ApoE receptor; apolipoprotein E receptor activity
Comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
lipoprotein particle receptor activity (GO:0030228)
Namespace: molecular_function
Definition: Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
Synonyms: lipoprotein receptor activity; plasma lipoprotein particle receptor activity
Comment: This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'.
very-low-density lipoprotein particle receptor activity (GO:0030229)
Namespace: molecular_function
Definition: Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.
Synonyms: apolipoprotein E receptor activity; very-low-density lipoprotein receptor activity; VLDL receptor
insulin control element activator complex (GO:0030232)
Namespace: cellular_component
Definition: Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription.
Synonyms: ICE activator complex
deoxynucleotide transmembrane transporter activity (GO:0030233)
Namespace: molecular_function
Definition: Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP.
enzyme regulator activity (GO:0030234)
Namespace: molecular_function
Definition: A molecular function regulator that modulates a catalytic activity.
Synonyms: catalytic regulator activity; enzyme modulator; metalloenzyme regulator activity
Comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.
nitric-oxide synthase regulator activity (GO:0030235)
Namespace: molecular_function
Definition: Binds to and modulates the activity of nitric oxide synthase.
Synonyms: nitric oxide synthase regulator activity
Comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'.
female sex determination (GO:0030237)
Namespace: biological_process
Definition: The specification of female sex of an individual organism.
male sex determination (GO:0030238)
Namespace: biological_process
Definition: The specification of male sex of an individual organism.