LiteFold/GO huggingface dataset:
sneeze reflex (GO:0160023)
Namespace: biological_process
Definition: A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane.
Synonyms: sternutation
Leydig cell proliferation (GO:0160024)
Namespace: biological_process
Definition: The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone.
sensory perception of itch (GO:0160025)
Namespace: biological_process
Definition: A sensory perception which causes the desire or reflex to scratch.
Synonyms: pruritus
egg deposition (GO:0160027)
Namespace: biological_process
Definition: The multicellular organismal reproductive process that results in the movement of an egg from within an organism into the external environment.
negative regulation of pyroptotic inflammatory response (GO:0160028)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of a pyroptotic inflammatory response.
Synonyms: negative regulation of pyroptosis
kidney cortex tubule cell dedifferentiation (GO:0160029)
Namespace: biological_process
Definition: The process in which a kidney cortex tubule cell (specialized epithelial cell of the kidney) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Comment: Following injury, renal cortex tubular epithelial cell appears to be undergoing epithelial-mesenchymal transition, detected by overexpression of vimentin. {xref="PMID:31847447"}
pollen intine formation (GO:0160030)
Namespace: biological_process
Definition: Formation of pollen intine, the inner layer of the pollen wall. The reticulate pollen wall pattern consists of two layers, exine and intine.
endoplasmic reticulum membrane biogenesis (GO:0160031)
Namespace: biological_process
Definition: The process in which an endoplasmic reticulum membrane is synthesized, aggregates, and bonds together.
Synonyms: ER membrane biogenesis
Toll receptor ligand protein activation cascade (GO:0160032)
Namespace: biological_process
Definition: A protein activation cascade that generates the active Toll receptor ligand and consists of the cascade of enzymatic reactions initiated by extracellular recognition factors, leading to the cleavage of the inactive form of spatzle family of ligands.
Comment: This term specifically mentions the Toll receptor and its ligand spatzle because this is the only known example of such an activation cascade for a ligand.
regulation of Toll receptor ligand protein activation cascade (GO:0160033)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the Toll receptor ligand protein activation cascade.
positive regulation of Toll receptor ligand protein activation cascade (GO:0160034)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of Toll receptor ligand protein activation cascade.
negative regulation of Toll receptor ligand protein activation cascade (GO:0160035)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of Toll receptor ligand protein activation cascade.
positive regulation of postsynaptic density assembly (GO:0160036)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of postsynaptic density assembly.
negative regulation of postsynaptic density assembly (GO:0160037)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency, or extent of postsynaptic density assembly.
somatic sensory system development (GO:0160038)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain.
Synonyms: somatosensory system development
serotonin-gated chloride channel activity (GO:0160039)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
mitocytosis (GO:0160040)
Namespace: biological_process
Definition: A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells.
neuropeptide activity (GO:0160041)
Namespace: molecular_function
Definition: The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron.
purine nucleotide uniporter activity (GO:0160042)
Namespace: molecular_function
Definition: Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.
catecholamine secretion, neurotransmission (GO:0160043)
Namespace: biological_process
Definition: The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter.
sulfate:chloride antiporter activity (GO:0160044)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in).
TMEM240-body (GO:0160045)
Namespace: cellular_component
Definition: A multilamellar subcellular structure formed in the cytoplasm of developing neuron, composed of Tmem240 and Emd proteins.
Synonyms: T240-body
oxalate:chloride antiporter activity (GO:0160046)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + oxalate(in) = chloride(in) + oxalate(out).
muramyl dipeptide kinase activity (GO:0160047)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + muramyl dipeptide = ADP + H+ + 6-O-phospho-muramyl dipeptide.
negative regulation of cGAS/STING signaling pathway (GO:0160049)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway.
xanthine binding (GO:0160050)
Namespace: molecular_function
Definition: Binding to xanthine, a purine base.
Cyc8(Ssn6)-Tup1 general repressor complex (GO:0160051)
Namespace: cellular_component
Definition: A corepressor complex containing the WD-repeat protein Tup1p (S. cerevisiae) and Tup11/Tup12 (fission yeast) and the TPR repeat protein Cyc8p (S. cerevisiae) ssn6 (fission yeast) that is recruited to target genes by DNA-bound repressor proteins preferentially at regions where histones are deacetylated by the Clr6 class I HDAC, and recruits the SWI/SNF and SAGA complexes to promoters.
Synonyms: Tup11/Tup12 repressor complex
mitotic nuclear envelope segregation (GO:0160052)
Namespace: biological_process
Definition: The mitotic cell cycle process in which the nuclear envelope, including nuclear pores, is equally distributed to the two daughter cells during the mitotic cell cycle.
serine-based site-specific recombinase activity (GO:0160053)
Namespace: molecular_function
Definition: Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphoseryl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a serine in the active site.
microfibril assembly (GO:0160054)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of microfibril.
glideosome (GO:0160055)
Namespace: cellular_component
Definition: A protein complex composed of at least GAP45 (gliding-associated protein), GAP50 and myosin heavy and light chains. Anchored via GAP50 to the inner membrane complex of motile and invasive forms of apicomplexan parasites and regulates parasite gliding motility and invasion of host cells.
plant endodermal cell fate specification (GO:0160057)
Namespace: biological_process
Definition: The process in which a cell becomes capable of differentiating autonomously into a plant endodermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
plant endodermal cell differentiation (GO:0160058)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a plant endodermal cell.
programmed cell death in response to retinoic acid (GO:0160059)
Namespace: biological_process
Definition: Cell death resulting from activation of endogenous cellular processes and occurring as a result of a retinoic acid.
Synonyms: retinoic acid-induced apoptosis
sleep homeostasis (GO:0160060)
Namespace: biological_process
Definition: A homeostatic process in which the drive for sleep increases sleep propensity with prolonged wakefulness.
respiratory chemosensitivity (GO:0160061)
Namespace: biological_process
Definition: A homeostatic process by which the sensing of CO2 and/or H+ by the brain leads to appropriate altering in breathing to regulate blood gas and tissue pH.
cutin-based cuticle development (GO:0160062)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the cutin-based cuticle over time, from its formation to the mature structure. Cutin-based cuticle is an extracellular structure composed of a covalently linked macromolecular scaffold of cutin and a variety of organic solvent-soluble lipids that are collectively termed waxes. Such structures are found on the external face of polysaccharide cell walls in land plants.
multi-pass transmembrane protein insertion into ER membrane (GO:0160063)
Namespace: biological_process
Definition: A process of protein insertion of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Insertion of multi-pass membrane proteins is mediated by the multi-pass translocon complex and takes place following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex to promote insertion of subsequent transmembrane regions.
SIN/MEN signaling complex (GO:0160065)
Namespace: cellular_component
Definition: A protein complex associated with the mitotic spindle pole body during interphase and mitosis and comprises of the proteins of the septation initiation signaling network (SIN) of fission yeast or mitotic exit network (MEN) of budding yeast, organized by two scaffold/adaptor proteins.
Synonyms: Hippo signaling complex; MEN signaling complex; SIN signaling complex; SIN/MEN signalling complex
interphase SIN signaling complex (GO:0160066)
Namespace: cellular_component
Definition: A SIN signaling complex associated with the old mitotic spindle pole body during interphase and early M-phase and characterised by the presence active ubiquitin ligase (Dma1 in fission yeast) and GTPase activator (Spg1 in fission yeast) to inactivate SIN signaling.
Synonyms: interphase SIN signalling complex
new spindle pole body SIN signaling complex (GO:0160067)
Namespace: cellular_component
Definition: A SIN signaling complex associated with the new mitotic spindle pole body during anaphase and characterized by the presence activated (GTP bound) GTPase (Spg1 in fission yeast) to activate SIN signaling.
Synonyms: new spindle pole body SIN signalling complex
negative regulation of pollen tube guidance (GO:0160068)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of pollen tube guidance towards ovules. This is one mechanism to prevent polytuby, the simultaneous penetration of ovules by multiple pollen tubes.
Synonyms: prevention of polytuby
surfactant secretion (GO:0160069)
Namespace: biological_process
Definition: The regulated release of surfactant by a cell or tissue.
intracellular borate homeostasis (GO:0160070)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of tetrahydroxoborate within a cell.
Synonyms: intracellular boron homeostasis; intracellular tetrahydroxoborate homeostasis
prevention of polyspermy during double fertilization (GO:0160071)
Namespace: biological_process
Definition: The regulation of double fertilization forming a zygote and endosperm process that ensures that only a single sperm cell fertilizes one egg cell and another single sperm cell fertilizes one central cell.
ubiquitin ligase complex scaffold activity (GO:0160072)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way.
Synonyms: core protein activity for the CUL-RING ubiquitin ligase complex; core protein activity for the Cullin-RING ubiquitin ligase complex
Casparian strip assembly (GO:0160073)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a Casparian strip, a region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material.
Synonyms: Casparian strip formation
non-canonical inflammasome complex assembly (GO:0160075)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a non-canonical inflammasome complex.
negative regulation of non-canonical inflammasome complex assembly (GO:0160076)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical inflammasome complex assembly.
lipid droplet fusion (GO:0160077)
Namespace: biological_process
Definition: The process by which a single lipid droplet is created from the fusion of two or more lipid droplets.
negative regulation of lipid droplet fusion (GO:0160078)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of lipid droplet fusion.
ABC-type indole transporter activity (GO:0160080)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + indole(in) = ADP + phosphate + indole(out).
iodide channel activity (GO:0160081)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of iodide through a transmembrane aqueous pore or channel.
hypoxia-inducible factor-proline dioxygenase activity (GO:0160082)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit].
Synonyms: HIF hydroxylase; HIF prolyl hydroxylase
exhausted T cell differentiation (GO:0160083)
Namespace: biological_process
Definition: The process in which an activated T cell acquires specialized features of an exhausted T cell.
Synonyms: T cell dysfuction; T cell exhaustion
spermatid cytoplasm removal during spermiation of flagellated sperm (GO:0160087)
Namespace: biological_process
Definition: The process of removing the majority of the cytoplasm and organelles from a spermatid as it develops into a mature flagellated sperm cell.
internal N(7)-methylguanine-containing RNA reader activity (GO:0160089)
Namespace: molecular_function
Definition: A protein adaptor that recognizes and binds an RNA molecule modified by N(7)-methylguanine (m7G), a modification present at internal sites of mRNAs and some non-coding RNAs.
internal mRNA (guanine-N7-)-methyltransferase activity (GO:0160090)
Namespace: molecular_function
Definition: Catalysis of the reaction: a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine.
spliceosome-depend formation of circular RNA (GO:0160091)
Namespace: biological_process
Definition: Formation of circular RNAs (circRNAs) by back-splicing circularization of pre-mRNAs in a spliceosome-dependent process.
hemozoin formation complex (GO:0160092)
Namespace: cellular_component
Definition: A protein-containing complex involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage of a Plasmodium. It is composed of at least falcipains FP2A and/or FP2B, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN.
chordate pharynx development (GO:0160093)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure.
nematode pharynx development (GO:0160094)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of nematode pharynx over time, from its formation to the mature structure.
insect pharynx development (GO:0160095)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of insect pharynx over time, from its formation to the mature structure.
nematode pharyngeal muscle development (GO:0160096)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the nematode pharyngeal muscle over time, from its formation to the mature structure.
reverse gyrase activity (GO:0160097)
Namespace: molecular_function
Definition: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle, is driven by ATP hydrolysis.
tRNA (guanine(10)-N2)-dimethyltransferase activity (GO:0160101)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine.
Synonyms: N(2),N(2)-dimethylguanosine tRNA methyltransferase; tRNA (guanine(10)-N(2))-dimethyltransferase activity; tRNA (guanosine(10)-N(2))-dimethyltransferase activity
tRNA (guanine(10)-N2)-methyltransferase activity (GO:0160102)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine(10) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine.
Synonyms: tRNA (guanine(10)-N(2))-methyltransferase activity; tRNA (guanosine(10)-N(2))-methyltransferase activity
tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity (GO:0160103)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H+ + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine.
Synonyms: tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase activity; tRNA (guanosine(26)-N(2)/guanosine(27)-N(2))-dimethyltransferase activity
tRNA (guanine(26)-N2)-dimethyltransferase activity (GO:0160104)
Namespace: molecular_function
Definition: Catalysis of the reaction:guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine.
Synonyms: tRNA (guanine(26)-N(2))-dimethyltransferase activity; tRNA (guanosine(26)-N(2))-dimethyltransferase activity; tRNA (m(2)2G26)dimethyltransferase
tRNA (adenine(22)-N1)-methyltransferase activity (GO:0160105)
Namespace: molecular_function
Definition: Catalysis of the reaction: adenosine(22) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine.
Synonyms: tRNA (adenine(22)-N(1))-methyltransferase activity; tRNA (adenosine(22)-N(1))-methyltransferase activity
tRNA (adenine(9)-N1)-methyltransferase activity (GO:0160106)
Namespace: molecular_function
Definition: Catalysis of the reaction: adenosine(9) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine.
Synonyms: tRNA (adenine(9)-N(1))-methyltransferase activity; tRNA m(1)A(9)-methyltransferase; tRNA(m(1)G(9)/m(1)A(9))-methyltransferase
tRNA (adenine(58)-N1)-methyltransferase activity (GO:0160107)
Namespace: molecular_function
Definition: Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine.
Synonyms: tRNA (adenine(58)-N(1))-methyltransferase activity; tRNA (m(1)A(58)) methyltransferase; tRNA m(1)A(58) methyltransferase
plant gross anatomical part developmental process (GO:0160109)
Namespace: biological_process
Definition: Any developmental process whose specific outcome is the progression of a gross anatomical part of a plant from an initial immature state, to a later, more mature state.
Synonyms: plant development
axonemal microtubule doublet inner sheath (GO:0160110)
Namespace: cellular_component
Definition: A structural network of microtubule inner proteins (MIPs) located inside the lumens of the A and B tubules of the axonemal microtuble doublet that helps stabilize the doublet microtubule.
axonemal A tubule inner sheath (GO:0160111)
Namespace: cellular_component
Definition: A structural network of microtubule inner proteins (MIPs) located inside the lumen of the A tubule of the axonemal microtubule doublet that helps stabilize the A tubule.
axonemal microtubule doublet inner junction (GO:0160113)
Namespace: cellular_component
Definition: The structure which joins the B10 protofilament of the B tubule to the A1 protofilament of the A tubule within an axonemal microtubule doublet.
axonemal microtubule doublet outer junction (GO:0160114)
Namespace: cellular_component
Definition: The structure which joins the B1 protofilament of the B tubule to the A10 and A11 protofilaments of the A tubule within an axonemal microtubule doublet.
axonemal microtubule doublet ribbon (GO:0160115)
Namespace: cellular_component
Definition: The 3 protofilaments A11, A12, and A13 of the A tubule along with associated inner sheath microtuble inner proteins (MIPs), either in the lumen of the A tubule or of the B tubule, which stabilize these three filiments within the axonemal doublet microtubule. The ribbon protofilaments separate the lumens of the A and B tubules.
tRNA (guanine(7)-N2)-methyltransferase activity (GO:0160118)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine(7) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(7) in tRNA + S-adenosyl-L-homocysteine.
cuproptosis (GO:0160119)
Namespace: biological_process
Definition: A programmed cell death process that is induced by intracellular copper accumulation.
obsolete mitochondrial branched-chain alpha-keto acid dehydrogenase complex (GO:0160120)
Namespace: cellular_component
Definition: OBSOLETE. A mitochondrial complex that catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex is organized around a 24-meric cubic core of the dihydrolipoyl transacylase (E2) with multiple (about 6 to 12) copies of the branched-chain alpha-ketoacid dehydrogenase (E1, consisting of alpha and beta subunits), about 6 copies of the dimeric dihydrolipoyl dehydrogenase (E3), and a small number of copies of the E1-specific kinase and phosphatase.
Synonyms: BCKD complex
Comment: This term is unnecessarily taxon-specific.
bis(monoacylglycero)phosphate synthase activity (GO:0160121)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol).
corneal epithelial cell differentiation (GO:0160122)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of an corneal epithelial cell, any of the cells making up an corneal epithelium.