LiteFold/GO huggingface dataset:
anaerobic fatty acid catabolic process (GO:1990486)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
Synonyms: anaerobic fatty acid degradation
anaerobic lignin catabolic process (GO:1990487)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units.
Synonyms: anaerobic lignin degradation
anaerobic cellulose catabolic process (GO:1990488)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen.
Synonyms: anaerobic cellulose degradation
anaerobic pectin catabolic process (GO:1990489)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen.
Synonyms: anaerobic pectin degradation
archaeal proton-transporting A-type ATPase complex (GO:1990490)
Namespace: cellular_component
Definition: A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea.
Synonyms: A-type ATPase protein complex; archaeal A-type ATPase protein complex
methane biosynthetic process from methanol and hydrogen (GO:1990491)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen.
Synonyms: methane biosynthesis from methanol and hydrogen; methanogenesis from methanol and hydrogen
obsolete mitotic cell cycle checkpoint inhibiting CAR assembly (GO:1990492)
Namespace: biological_process
Definition: OBSOLETE. A Mad2-dependent mitotic cell cycle checkpoint which delays cytokinetic actinomycin ring assembly if there is a delay in early M-phase.
Synonyms: Mad2-dependent mitotic cell cycle checkpoint; mitotic cell cycle checkpoint inhibiting cytokinetic actomyosin ring assembly
Comment: This term was obsoleted because it does not represent a specific process.
obsolete regulation of mitotic cytokinesis, actomyosin contractile ring assembly (GO:1990494)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cytokinesis, actomyosin contractile ring assembly.
Synonyms: regulation of mitotic cytokinesis, actomyosin contractile ring assembly
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly (GO:1990496)
Namespace: biological_process
Definition: OBSOLETE. An actin filament organization process that contributes to regulation of actomyosin contractile ring assembly during mitotic cytokinesis.
Synonyms: regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
regulation of cytoplasmic translation in response to stress (GO:1990497)
Namespace: biological_process
Definition: Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
mitotic spindle microtubule (GO:1990498)
Namespace: cellular_component
Definition: Any microtubule that is part of a mitotic spindle; anchored at one spindle pole.
raps-insc complex (GO:1990499)
Namespace: cellular_component
Definition: Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2).
Synonyms: partner of inscuteable-inscuteable complex; Rapsynoid-Inscuteable complex
Comment: An example of this is Insc in drome (Q9W2R4) in PMID:22171003 (inferred from physical interaction).
eif4e-cup complex (GO:1990500)
Namespace: cellular_component
Definition: A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo.
Synonyms: eukaryotic translation initiation factor 4E-cup complex
Comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction).
exon-exon junction subcomplex mago-y14 (GO:1990501)
Namespace: cellular_component
Definition: Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA.
Synonyms: exon junction subcomplex MAGOH-Y14; mago-y14 complex; MGN-RBM8A complex
Comment: An example of this is Mago in drome (P49028) in PMID:12730685 (inferred from direct assay).
dense core granule maturation (GO:1990502)
Namespace: biological_process
Definition: Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.
Synonyms: dense core vesicle maturation
dendritic lamellar body (GO:1990503)
Namespace: cellular_component
Definition: A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions.
Synonyms: DLB
dense core granule exocytosis (GO:1990504)
Namespace: biological_process
Definition: The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms: dense core vesicle exocytosis
mitotic DNA replication maintenance of fidelity (GO:1990505)
Namespace: biological_process
Definition: Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication.
Synonyms: maintenance of fidelity involved in mitotic cell cycle DNA replication; maintenance of fidelity involved in mitotic DNA replication
mitotic DNA-templated DNA replication (GO:1990506)
Namespace: biological_process
Definition: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle.
Synonyms: mitotic DNA-dependent DNA replication
obsolete ATP-independent chaperone mediated protein folding (GO:1990507)
Namespace: biological_process
Definition: OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis.
Comment: This term was obsoleted because it represents a molecular function.
CKM complex (GO:1990508)
Namespace: cellular_component
Definition: Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8.
Synonyms: CDK8 kinase module; SRB8-SRB11 complex; SRB8/9/10/11 complex
Comment: An example of this is SSN2 in Saccharomyces cerevisiae (P38931) in PMID:12200444 (inferred from physical interaction).
PYM-mago-Y14 complex (GO:1990509)
Namespace: cellular_component
Definition: Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans.
Synonyms: PYM-mago-RNA-binding protein 8A complex; wibg-mago-tsu complex
Comment: An example of this is wibg in Drosophila melanogaster (P82804) in PMID:14968132 (inferred from physical interaction).
Cry-Per complex (GO:1990512)
Namespace: cellular_component
Definition: Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms.
Comment: An example of this is Cry1 in mouse (P97784) in PMID:24855952 (inferred from physical interaction).
CLOCK-BMAL transcription complex (GO:1990513)
Namespace: cellular_component
Definition: Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.
Synonyms: CLOCK/BMAL complex
Comment: An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
5' transitive RNA interference (GO:1990514)
Namespace: biological_process
Definition: An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA.
ribonucleotide excision repair (GO:1990516)
Namespace: biological_process
Definition: The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase.
obsolete protein localization to photoreceptor outer segment (GO:1990517)
Namespace: biological_process
Definition: OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
single-stranded 3'-5' DNA helicase activity (GO:1990518)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.
pyrimidine nucleotide import into mitochondrion (GO:1990519)
Namespace: biological_process
Definition: The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix.
Synonyms: mitochondrial pyrimidine nucleotide import
separase-securin complex (GO:1990520)
Namespace: cellular_component
Definition: A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC).
Synonyms: Cut1-2 complex
obsolete m7G(5')pppN diphosphatase activator activity (GO:1990521)
Namespace: molecular_function
Definition: OBSOLETE. Binds to and increases the activity of m7G(5')pppN diphosphatase.
Comment: This term was obsoleted because the obsoleted EC was obsoleted.
tail spike morphogenesis (GO:1990522)
Namespace: biological_process
Definition: The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death.
bone regeneration (GO:1990523)
Namespace: biological_process
Definition: The regrowth of bone following its loss or destruction.
INA complex (GO:1990524)
Namespace: cellular_component
Definition: A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p.
Synonyms: INAC
BIR domain binding (GO:1990525)
Namespace: molecular_function
Definition: Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain.
Synonyms: Baculovirus Inhibitor of apoptosis protein Repeat domain binding
Comment: An example of this is the Drosophila reaper gene in PMID:21886178.
Ste12p-Dig1p-Dig2p complex (GO:1990526)
Namespace: cellular_component
Definition: A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae.
Tec1p-Ste12p-Dig1p complex (GO:1990527)
Namespace: cellular_component
Definition: A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae.
glycosylphosphatidylinositol-mannosyltransferase I complex (GO:1990529)
Namespace: cellular_component
Definition: A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.
Synonyms: GPI-MT-I complex
phospholipid-translocating ATPase complex (GO:1990531)
Namespace: cellular_component
Definition: A protein complex that functions as a phospholipid-translocating P-Type ATPase.
Synonyms: aminophospholipid translocase complex; APLT complex; CDC50-DRS2 complex; CRF1-DNF3 complex; Dnf1-Lem3 complex; Dnf2-Lem3 complex; DNF3-CRF1 complex; DRS2-CDC50 complex; Lem3-Dnf1 complex; Lem3p-Dnf1p complex; P4-ATPase complex; phospholipid flippase complex
stress response to nickel ion (GO:1990532)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus.
Synonyms: response to nickel ion stress; response to nickel toxicity; stress response to nickel
Dom34-Hbs1 complex (GO:1990533)
Namespace: cellular_component
Definition: A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay.
Synonyms: Dom34:Hbs1 complex
thermospermine oxidase activity (GO:1990534)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine.
neuron projection maintenance (GO:1990535)
Namespace: biological_process
Definition: The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
Synonyms: axon homeostasis; axon maintenance; neurite maintenance; neuron process maintenance; neuron protrusion maintenance; neuronal cell projection maintenance
phosphoenolpyruvate transmembrane import into Golgi lumen (GO:1990536)
Namespace: biological_process
Definition: The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane.
xylan O-acetyltransferase activity (GO:1990538)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan.
fructose import across plasma membrane (GO:1990539)
Namespace: biological_process
Definition: The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.
Synonyms: fructose import; fructose uptake
mitochondrial manganese ion transmembrane transport (GO:1990540)
Namespace: biological_process
Definition: The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial transmembrane transport (GO:1990542)
Namespace: biological_process
Definition: The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.
mitochondrial S-adenosyl-L-methionine transmembrane transport (GO:1990543)
Namespace: biological_process
Definition: The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial ATP transmembrane transport (GO:1990544)
Namespace: biological_process
Definition: The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial thiamine pyrophosphate transmembrane transport (GO:1990545)
Namespace: biological_process
Definition: The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial tricarboxylic acid transmembrane transport (GO:1990546)
Namespace: biological_process
Definition: The process in which a tricarboxylic acid is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial phosphate ion transmembrane transport (GO:1990547)
Namespace: biological_process
Definition: The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial FAD transmembrane transport (GO:1990548)
Namespace: biological_process
Definition: The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial NAD transmembrane transport (GO:1990549)
Namespace: biological_process
Definition: The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial alpha-ketoglutarate transmembrane transport (GO:1990550)
Namespace: biological_process
Definition: The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion.
Synonyms: mitochondrial 2-oxoglutarate transmembrane transport
mitochondrial 2-oxoadipate transmembrane transport (GO:1990551)
Namespace: biological_process
Definition: The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial 5'-adenylyl sulfate transmembrane transport (GO:1990553)
Namespace: biological_process
Definition: The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport (GO:1990554)
Namespace: biological_process
Definition: The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial oxaloacetate transmembrane transport (GO:1990555)
Namespace: biological_process
Definition: The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial isopropylmalate transmembrane transport (GO:1990556)
Namespace: biological_process
Definition: The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial sulfate transmembrane transport (GO:1990557)
Namespace: biological_process
Definition: The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial malonate(1-) transmembrane transport (GO:1990558)
Namespace: biological_process
Definition: The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion.
obsolete DNA methyltransferase binding (GO:1990560)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a DNA methyltransferase.
Synonyms: DNA methyltransferase binding
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion starvation (GO:1990561)
Namespace: biological_process
Definition: OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of copper ions.
Comment: This term was obsoleted because it represents a GO-CAM model.
syndecan-syntenin-ALIX complex (GO:1990562)
Namespace: cellular_component
Definition: An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery.
Synonyms: exosome complex
Comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction).
extracellular exosome complex (GO:1990563)
Namespace: cellular_component
Definition: A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome.
Synonyms: exosome complex; extracellular vesicular exosome complex
Comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction).
protein polyufmylation (GO:1990564)
Namespace: biological_process
Definition: Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain.
HSP90-CDC37 chaperone complex (GO:1990565)
Namespace: cellular_component
Definition: A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.
Comment: An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay).
DPS complex (GO:1990567)
Namespace: cellular_component
Definition: A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22.