LiteFold/GO huggingface dataset:
positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
Synonyms: activation of insulin-like growth factor receptor signaling pathway; positive regulation of IGF receptor signaling pathway; positive regulation of IGF receptor signalling pathway; positive regulation of insulin-like growth factor receptor signalling pathway; stimulation of insulin-like growth factor receptor signaling pathway; up regulation of insulin-like growth factor receptor signaling pathway; up-regulation of insulin-like growth factor receptor signaling pathway; upregulation of insulin-like growth factor receptor signaling pathway
negative regulation of insulin-like growth factor receptor signaling pathway (GO:0043569)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
Synonyms: down regulation of insulin-like growth factor receptor signaling pathway; down-regulation of insulin-like growth factor receptor signaling pathway; downregulation of insulin-like growth factor receptor signaling pathway; inhibition of insulin-like growth factor receptor signaling pathway; negative regulation of IGF receptor signaling pathway; negative regulation of IGF receptor signalling pathway; negative regulation of insulin-like growth factor receptor signalling pathway
maintenance of DNA repeat elements (GO:0043570)
Namespace: biological_process
Definition: Any process involved in sustaining the fidelity and copy number of DNA repeat elements.
maintenance of CRISPR repeat elements (GO:0043571)
Namespace: biological_process
Definition: Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences.
Synonyms: CRISPR element metabolic process; CRISPR element metabolism; maintenance of clustered regularly interspaced short palindromic repeat elements
plastid fission (GO:0043572)
Namespace: biological_process
Definition: The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA.
leucoplast fission (GO:0043573)
Namespace: biological_process
Definition: The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes.
peroxisomal transport (GO:0043574)
Namespace: biological_process
Definition: Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
detection of osmotic stimulus (GO:0043575)
Namespace: biological_process
Definition: The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal.
regulation of respiratory gaseous exchange (GO:0043576)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.
chemotropism (GO:0043577)
Namespace: biological_process
Definition: The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it.
nuclear matrix organization (GO:0043578)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane.
Synonyms: nuclear matrix organisation; nuclear matrix organization and biogenesis; nucleoskeleton organization
elaioplast organization (GO:0043579)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored.
Synonyms: elaioplast organisation; elaioplast organization and biogenesis
periplasmic space organization (GO:0043580)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi.
Synonyms: periplasmic space organisation; periplasmic space organization and biogenesis
obsolete mycelium development (GO:0043581)
Namespace: biological_process
Definition: OBSOLETE. The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium consists of a mass of branching, thread-like hyphae.
Comment: The reason for obsoletion is that the term is ambiguous. Three more clearly defined terms have been created that should be considered in its place.
ear development (GO:0043583)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
Synonyms: hearing organ development
nose development (GO:0043584)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).
Synonyms: nasus development
nose morphogenesis (GO:0043585)
Namespace: biological_process
Definition: The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).
Synonyms: nasus morphogenesis
tongue development (GO:0043586)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.
Synonyms: glossa development; lingua development
tongue morphogenesis (GO:0043587)
Namespace: biological_process
Definition: The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.
Synonyms: glossa morphogenesis; lingua morphogenesis
skin development (GO:0043588)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
Synonyms: animal skin development
skin morphogenesis (GO:0043589)
Namespace: biological_process
Definition: The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
bacterial nucleoid (GO:0043590)
Namespace: cellular_component
Definition: The region of a bacterial cell to which the DNA is confined.
endospore external encapsulating structure (GO:0043591)
Namespace: cellular_component
Definition: The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer.
Synonyms: endospore wall; peptidoglycan-based spore wall; spore wall
endospore coat (GO:0043593)
Namespace: cellular_component
Definition: The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination.
endospore cortex (GO:0043595)
Namespace: cellular_component
Definition: A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan.
nuclear replication fork (GO:0043596)
Namespace: cellular_component
Definition: The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
cytoplasmic replication fork (GO:0043597)
Namespace: cellular_component
Definition: The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
cytoplasmic DNA replication factor C complex (GO:0043598)
Namespace: cellular_component
Definition: A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species.
Synonyms: cytoplasmic clamp loader; cytoplasmic RFC
nuclear DNA replication factor C complex (GO:0043599)
Namespace: cellular_component
Definition: A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species.
Synonyms: nuclear RFC
cytoplasmic replisome (GO:0043600)
Namespace: cellular_component
Definition: A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins.
Synonyms: prokaryotic replisome
nuclear replisome (GO:0043601)
Namespace: cellular_component
Definition: A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
nitrate catabolic process (GO:0043602)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid.
Synonyms: nitrate disassimilation; nitrate dissimilation
obsolete amide biosynthetic process (GO:0043604)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
obsolete amide catabolic process (GO:0043605)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
obsolete formamide metabolic process (GO:0043606)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid.
Synonyms: formamide metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete formamide biosynthetic process (GO:0043607)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid.
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete formamide catabolic process (GO:0043608)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid.
Comment: This term was obsoleted because it is an unnecessary grouping term.
regulation of carbon utilization (GO:0043609)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of carbon utilization.
regulation of carbohydrate utilization (GO:0043610)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of carbohydrate utilization.
Synonyms: regulation of sugar utilization
isoprene metabolic process (GO:0043611)
Namespace: biological_process
Definition: The chemical reactions and pathways involving isoprene, C5H8.
Synonyms: 2-methyl-1,3-butadiene metabolic process; 2-methyl-1,3-butadiene metabolism; hemiterpene metabolic process; hemiterpene metabolism; isoprene metabolism
isoprene catabolic process (GO:0043613)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8.
Synonyms: 2-methyl-1,3-butadiene catabolic process; 2-methyl-1,3-butadiene catabolism; hemiterpene catabolic process; hemiterpene catabolism
multi-eIF complex (GO:0043614)
Namespace: cellular_component
Definition: A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
Synonyms: multifactor translation initiation factor (eIF) complex
astrocyte cell migration (GO:0043615)
Namespace: biological_process
Definition: The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord.
Synonyms: astrocyte migration; astrocytic glial cell migration
keratinocyte proliferation (GO:0043616)
Namespace: biological_process
Definition: The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.
cellular response to sucrose starvation (GO:0043617)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose.
obsolete regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043619)
Namespace: biological_process
Definition: OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete regulation of DNA-templated transcription in response to stress (GO:0043620)
Namespace: biological_process
Definition: OBSOLETE. Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
Synonyms: regulation of DNA-dependent transcription in response to stress
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete protein self-association (GO:0043621)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a domain within the same polypeptide.
Synonyms: intramolecular protein binding; protein self association; protein self binding
Comment: Out of scope; capture mechanistic information about binding.
cortical microtubule organization (GO:0043622)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
Synonyms: cortical microtubule cytoskeleton organization; cortical microtubule organisation; cortical microtubule organization and biogenesis
delta DNA polymerase complex (GO:0043625)
Namespace: cellular_component
Definition: A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.
Synonyms: delta-DNA polymerase complex
PCNA complex (GO:0043626)
Namespace: cellular_component
Definition: A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
Synonyms: PCNA homotrimer; proliferating cell nuclear antigen complex; sliding clamp
response to estrogen (GO:0043627)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
Synonyms: response to 17alpha-ethynylestradiol; response to estrogen stimulus; response to oestrogen stimulus
regulatory ncRNA 3'-end processing (GO:0043628)
Namespace: biological_process
Definition: Any process involved in forming the mature 3' end of a regulatory non-coding RNA molecule.
Synonyms: ncRNA 3' end processing; ncRNA 3'-end processing; small regulatory ncRNA 3'-end processing
obsolete ncRNA polyadenylation (GO:0043629)
Namespace: biological_process
Definition: OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation.
Synonyms: non-coding RNA polyadenylation
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process (GO:0043630)
Namespace: biological_process
Definition: OBSOLETE. The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism.
Synonyms: ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process; ncRNA polyadenylation involved in poly(A)-dependent ncRNA catabolic process
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete RNA polyadenylation (GO:0043631)
Namespace: biological_process
Definition: OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.
Comment: The reason for obsoletion is that this term represents a molecular function.
modification-dependent macromolecule catabolic process (GO:0043632)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule.
polyadenylation-dependent RNA catabolic process (GO:0043633)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA.
polyadenylation-dependent ncRNA catabolic process (GO:0043634)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA.
Synonyms: poly(A)-dependent ncRNA catabolic process
methylnaphthalene catabolic process (GO:0043635)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar.
Synonyms: 1-methylnaphthalene catabolic process; 1-methylnaphthalene catabolism; 1-MN catabolic process; 1-MN catabolism; 2-methylnaphthalene catabolic process; 2-methylnaphthalene catabolism; 2-MN catabolic process; 2-MN catabolism