LiteFold/GO huggingface dataset:
obsolete MIS18 complex (GO:1990568)
Namespace: cellular_component
Definition: OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly.
Synonyms: MIS18 complex
Comment: An example of this is MIS18A in human (Q9NYP9) in PMID:25036634 (inferred from physical interaction).
UDP-N-acetylglucosamine transmembrane transport (GO:1990569)
Namespace: biological_process
Definition: The process in which UDP-N-acetylglucosamine is transported across a membrane.
Synonyms: UDP-N-acetylglucosamine transport
GDP-mannose transmembrane transport (GO:1990570)
Namespace: biological_process
Definition: The process in which GDP-mannose is transported across a membrane.
Synonyms: GDP-mannose transport
meiotic centromere clustering (GO:1990571)
Namespace: biological_process
Definition: The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I.
Synonyms: centromere clustering during meiosis; homologous chromosome movement towards spindle pole in meiosis I prometaphase
TERT-RMRP complex (GO:1990572)
Namespace: cellular_component
Definition: A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP).
Synonyms: telomerase reverse transcriptase:RMRP RNA complex
potassium ion import across plasma membrane (GO:1990573)
Namespace: biological_process
Definition: The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
Synonyms: potassium import; potassium ion import; potassium ion uptake
meiotic spindle astral microtubule (GO:1990574)
Namespace: cellular_component
Definition: Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
mitochondrial L-ornithine transmembrane transport (GO:1990575)
Namespace: biological_process
Definition: The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion.
Synonyms: mitochondrial ornithine transmembrane transport; mitochondrial ornithine transport
C-terminal protein demethylation (GO:1990577)
Namespace: biological_process
Definition: The removal of a methyl group from the C-terminal amino acid of a protein.
perinuclear endoplasmic reticulum membrane (GO:1990578)
Namespace: cellular_component
Definition: The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus.
Synonyms: perinuclear ER membrane
peptidyl-serine trans-autophosphorylation (GO:1990579)
Namespace: biological_process
Definition: The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer.
Synonyms: serine autophosphorylation in trans; serine transautophosphorylation
regulation of cytoplasmic translational termination (GO:1990580)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of cytoplasmic translational termination.
obsolete intracellular membrane-bounded organelle binding (GO:1990582)
Namespace: molecular_function
Definition: OBSOLETE. The temporary binding of a protein or protein complex to the membrane of an intracellular membrane-bounded organelle.
Synonyms: intracellular membrane-bounded organelle binding; intracellular membrane-enclosed organelle binding
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
phospholipase D activator activity (GO:1990583)
Namespace: molecular_function
Definition: Binds to and increases the activity of the enzyme phospholipase D.
cardiac Troponin complex (GO:1990584)
Namespace: cellular_component
Definition: A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
Synonyms: cTnC:cTnI:cTnT
hydroxyproline O-arabinosyltransferase activity (GO:1990585)
Namespace: molecular_function
Definition: Catalysis of the reaction: trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H+ + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP.
Synonyms: HPAT
FtsQBL complex (GO:1990587)
Namespace: cellular_component
Definition: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ.
Synonyms: FtsB-FtsL-FtsQ complex
Comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction).
FtsBL complex (GO:1990588)
Namespace: cellular_component
Definition: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL.
Synonyms: FtsB-FtsL complex
Comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction).
ATF4-CREB1 transcription factor complex (GO:1990589)
Namespace: cellular_component
Definition: Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.
ATF1-ATF4 transcription factor complex (GO:1990590)
Namespace: cellular_component
Definition: Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.
Comment: An example of this is ATF1in human (P18846) in PMID:12871976 (inferred from physical interaction).
asparagine transmembrane import into vacuole (GO:1990591)
Namespace: biological_process
Definition: The directed movement of asparagine into the vacuole across the vacuolar membrane.
protein K69-linked ufmylation (GO:1990592)
Namespace: biological_process
Definition: A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.
nascent polypeptide-associated complex binding (GO:1990593)
Namespace: molecular_function
Definition: Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
Synonyms: NAC binding; NACA binding
L-altrarate dehydratase activity (GO:1990594)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O.
Synonyms: L-talarate dehydratase activity
obsolete histone H3-K4 deacetylation (GO:1990596)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
AIP1-IRE1 complex (GO:1990597)
Namespace: cellular_component
Definition: A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).
Synonyms: AIP1-ERN1 complex; IRE1-DAB2IP complex; IRE1alpha-AIP1 complex
3' overhang single-stranded DNA endonuclease activity (GO:1990599)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks.
Synonyms: 3' overhang single-stranded DNA endodeoxyribonuclease activity
single-stranded DNA endodeoxyribonuclease activator activity (GO:1990600)
Namespace: molecular_function
Definition: Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity.
5' overhang single-stranded DNA endonuclease activity (GO:1990601)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks.
Synonyms: 5' overhang single-stranded DNA endodeoxyribonuclease activity
dark adaptation (GO:1990603)
Namespace: biological_process
Definition: The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.
Comment: The proteins RGS9-1 and Gb5L localize to the rod inner segment during dark adaptation, but to the rod outer segment during light adaptation. PMID:23555598
IRE1-TRAF2-ASK1 complex (GO:1990604)
Namespace: cellular_component
Definition: A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K).
Synonyms: ERN1-TRAF2-ASK1 complex
GU repeat RNA binding (GO:1990605)
Namespace: molecular_function
Definition: Binding to an RNA molecule containing GU repeats.
membrane scission GTPase motor activity (GO:1990606)
Namespace: molecular_function
Definition: Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis.
obsolete detection of stimulus involved in cytokinesis after mitosis checkpoint (GO:1990607)
Namespace: biological_process
Definition: OBSOLETE. The series of events in which information about whether cytokinesis has correctly completed, is received and converted into a molecular signal, contributing to a cytokinesis after mitosis checkpoint.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
mitotic spindle pole body localization (GO:1990608)
Namespace: biological_process
Definition: A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location.
Synonyms: establishment and maintenance of spindle pole body localization; establishment of spindle pole body localisation; establishment of spindle pole body localization; mitotic spindle pole body localization to nuclear envelope; spindle pole body docking; spindle pole body localisation in nuclear envelope; spindle pole body localization in nuclear envelope; spindle pole body localization to nuclear envelope; spindle pole body positioning
glutamate-cysteine ligase regulator activity (GO:1990609)
Namespace: molecular_function
Definition: Binds to and modulates the activity of glutamate-cysteine ligase.
acetolactate synthase regulator activity (GO:1990610)
Namespace: molecular_function
Definition: Binds to and modulates the activity of acetolactate synthase.
regulation of cytoplasmic translational initiation in response to stress (GO:1990611)
Namespace: biological_process
Definition: Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
Sad1-Kms1 LINC complex (GO:1990612)
Namespace: cellular_component
Definition: A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair.
Kelch-containing formin regulatory complex (GO:1990615)
Namespace: cellular_component
Definition: A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p.
Synonyms: Bud14-Kel1-Kel2 complex; KFRC complex
magnesium ion export from mitochondrion (GO:1990616)
Namespace: biological_process
Definition: The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore.
Synonyms: magnesium ion efflux from mitochondrion
CHOP-ATF4 complex (GO:1990617)
Namespace: cellular_component
Definition: A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits.
Synonyms: ATF4-CHOP heterodimer; CHOP-ATF4 heterodimer; CHOP-CREB-2 complex; CHOP/ATF4 complex; GADD153-ATF4 complex
obsolete ANPR-A:ANP complex (GO:1990618)
Namespace: cellular_component
Definition: OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis.
Synonyms: ANPR-A:ANP complex
Comment: An example of this is [ANPR-A:ANP] in [rat] (P18910:P01161-PRO_0000391785) in PMID:15117952 (inferred from direct assay).
obsolete histone H3-K9 deacetylation (GO:1990619)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
ANPR-A receptor complex (GO:1990620)
Namespace: cellular_component
Definition: A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.
Synonyms: NPR1 receptor complex
Comment: An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
ESCRT IV complex (GO:1990621)
Namespace: cellular_component
Definition: An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1.
Synonyms: ESCRT-IV; vacuolar protein sorting-associated complex; Vps4 complex; Vps4-Vta1 complex; VPS4A-VPS4B; VPS4A/B complex; Vta1-Vps4 complex
CHOP-ATF3 complex (GO:1990622)
Namespace: cellular_component
Definition: A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.
Synonyms: ATF3-CHOP complex; CHOP-ATF3 heterodimer; CHOP-ATF3 heterodimeric complex; GADD153-ATF3 complex
Herring body (GO:1990623)
Namespace: cellular_component
Definition: The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively.
Synonyms: neurosecretory body
guanyl nucleotide exchange factor inhibitor activity (GO:1990624)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.
negative regulation of cytoplasmic translational initiation in response to stress (GO:1990625)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.
mitochondrial outer membrane fusion (GO:1990626)
Namespace: biological_process
Definition: The membrane organization process that joins two mitochondrial outer membranes to form a single membrane.
Synonyms: mitochondrion outer membrane fusion
mitochondrial inner membrane fusion (GO:1990627)
Namespace: biological_process
Definition: The membrane organization process that joins two mitochondrial inner membranes to form a single membrane.
Synonyms: mitochondrion inner membrane fusion
phospholamban complex (GO:1990629)
Namespace: cellular_component
Definition: A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels.
Synonyms: cardiac phospholamban complex; cardiac PLB complex; cardiac PLN complex
Comment: An example of this is PLN in human (UniProt symbol P26678) in PMID:16043693 (inferred from direct assay).
ErbB-4 class receptor binding (GO:1990631)
Namespace: molecular_function
Definition: Binding to the protein-tyrosine kinase receptor ErbB-4/HER4.
Synonyms: HER4 receptor binding
mutator focus (GO:1990633)
Namespace: cellular_component
Definition: A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules.
protein phosphatase 5 binding (GO:1990634)
Namespace: molecular_function
Definition: Binding to protein phosphatase 5.
Synonyms: protein phosphatase T binding
response to prolactin (GO:1990637)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation.
response to granulocyte colony-stimulating factor (GO:1990638)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus.
Synonyms: response to G-CSF
obsolete inositol-3,4,5-trisphosphate 5-phosphatase activity (GO:1990639)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4,5-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.
Synonyms: inositol-3,4,5-trisphosphate 5-phosphatase activity
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
inositol-2,4,5-triphosphate 5-phosphatase activity (GO:1990640)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate.
response to iron ion starvation (GO:1990641)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.
obsolete response to castration (GO:1990642)
Namespace: biological_process
Definition: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a castration stimulus, deprivation of gonads.
Synonyms: response to castration
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
cellular response to granulocyte colony-stimulating factor (GO:1990643)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus.
microtubule site clamp (GO:1990644)
Namespace: molecular_function
Definition: The binding activity of a molecule that attaches the spindle microtubules to the kinetochore.
obsolete phosphorylase dephosphorylation (GO:1990645)
Namespace: biological_process
Definition: OBSOLETE. The modification of phosphorylases by removal of phosphate groups.
Synonyms: phosphorylase dephosphorylation
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
cellular response to prolactin (GO:1990646)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus.
C/EBP complex (GO:1990647)
Namespace: cellular_component
Definition: A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities.
Synonyms: C/EBP homodimer complex; C/EBP transcription factor complex; C/EBPalpha complex; C/EBPalpha homodimer complex; C/EBPbeta complex; C/EBPbeta homodimer complex
Comment: An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay).
inositol-4,5,6-triphosphate 5-phosphatase activity (GO:1990648)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate.
inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity (GO:1990649)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate.
inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity (GO:1990650)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate.
inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity (GO:1990651)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate.