LiteFold/GO huggingface dataset:
obsolete activation of Pbs2 (GO:0007238)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: activation of Pbs2
Comment: This term was made obsolete because it contains gene product and species specific information.
obsolete activation of Hog1 (GO:0007239)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: activation of Hog1
Comment: This term was made obsolete because it contains gene product and species specific information.
obsolete inactivation of Hog1 (GO:0007241)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: inactivation of Hog1
Comment: This term was made obsolete because it contains gene product and species specific information.
obsolete MAPKKK cascade (mating sensu Saccharomyces) (GO:0007244)
Namespace: biological_process
Definition: OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces.
Synonyms: MAPKKK cascade (mating sensu Saccharomyces)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete activation of MAPKKK (mating sensu Saccharomyces) (GO:0007245)
Namespace: biological_process
Definition: OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.
Synonyms: activation of MAPKKK (mating sensu Saccharomyces)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete activation of MAPKK (mating sensu Saccharomyces) (GO:0007246)
Namespace: biological_process
Definition: OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces.
Synonyms: activation of MAPKK (mating sensu Saccharomyces)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete activation of MAPK (mating sensu Saccharomyces) (GO:0007247)
Namespace: biological_process
Definition: OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.
Synonyms: activation of MAPK (mating sensu Saccharomyces)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete nuclear translocation of MAPK (mating sensu Saccharomyces) (GO:0007248)
Namespace: biological_process
Definition: OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces.
Synonyms: nuclear translocation of MAPK (mating sensu Saccharomyces)
Comment: This term was made obsolete because it is a gene product specific term.
canonical NF-kappaB signal transduction (GO:0007249)
Namespace: biological_process
Definition: An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).
Synonyms: canonical NF-kappaB signaling cascade; I-kappaB kinase/NF-kappaB cascade; I-kappaB kinase/NF-kappaB signal transduction; I-kappaB kinase/NF-kappaB signaling; NF-kappaB cascade; p50-dependent NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity (GO:0007250)
Namespace: biological_process
Definition: The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.
Synonyms: activation of NIK activity; positive regulation of NF-kappaB-inducing kinase activity
obsolete activation of the inhibitor of kappa kinase (GO:0007251)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: activation of the inhibitor of kappa kinase
Comment: This term was made obsolete because its meaning was unclear.
I-kappaB phosphorylation (GO:0007252)
Namespace: biological_process
Definition: The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms: IkappaB phosphorylation; IKB phosphorylation; inhibitor of kappaB phosphorylation; inhibitor of NF-kappaB phosphorylation
obsolete cytoplasmic sequestering of NF-kappaB (GO:0007253)
Namespace: biological_process
Definition: OBSOLETE. The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
Synonyms: cytoplasmic NF-kappaB retention; cytoplasmic NF-kappaB sequestration; cytoplasmic NF-kappaB storage; cytoplasmic retention of NF-kappaB; cytoplasmic sequestration of NF-kappaB; cytoplasmic storage of NF-kappaB; maintenance of NF-kappaB location in cytoplasm
Comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
JNK cascade (GO:0007254)
Namespace: biological_process
Definition: A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Synonyms: c-Jun N-terminal kinase cascade; JNK1 cascade; JNK2 cascade; JNK3 cascade; MAPK10 cascade; MAPK8 cascade; MAPK9 cascade; SAPK cascade; stress-activated protein kinase cascade
obsolete activation of JNKK activity (GO:0007256)
Namespace: biological_process
Definition: OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.
Synonyms: activation of JUN kinase kinase activity; positive regulation of JUNKK activity
Comment: This term was obsoleted because it represents a molecular function.
obsolete activation of JUN kinase activity (GO:0007257)
Namespace: biological_process
Definition: OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase (JNK).
Synonyms: activation of SAPK activity
JUN phosphorylation (GO:0007258)
Namespace: biological_process
Definition: The process of introducing a phosphate group into a JUN protein.
cell surface receptor signaling pathway via JAK-STAT (GO:0007259)
Namespace: biological_process
Definition: A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
Synonyms: JAK-STAT cascade; JAK-STAT signal transduction; receptor signaling pathway via JAK-STAT
obsolete JAK-induced STAT protein dimerization (GO:0007261)
Namespace: biological_process
Definition: OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
Synonyms: JAK-induced STAT protein dimerization
Comment: This term was made obsolete because it is ambiguous, and protein dimerization is represented by molecular function terms.
nitric oxide mediated signal transduction (GO:0007263)
Namespace: biological_process
Definition: An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
Synonyms: nitric oxide signaling; nitric oxide-mediated signal transduction; NO mediated signal transduction; NO-mediated signal transduction
small GTPase-mediated signal transduction (GO:0007264)
Namespace: biological_process
Definition: An intracellular signaling cassette in which a small monomeric GTPase relays a signal.
Synonyms: Ras family protein signal transduction; small GTPase mediated signal transduction
Ras protein signal transduction (GO:0007265)
Namespace: biological_process
Definition: An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal.
Synonyms: Ras mediated signal transduction
Rho protein signal transduction (GO:0007266)
Namespace: biological_process
Definition: An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal.
Synonyms: Rho mediated signal transduction
cell-cell signaling (GO:0007267)
Namespace: biological_process
Definition: Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
Synonyms: cell-cell signalling
chemical synaptic transmission (GO:0007268)
Namespace: biological_process
Definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms: neurotransmission; signal transmission across a synapse; synaptic transmission
neuron-neuron synaptic transmission (GO:0007270)
Namespace: biological_process
Definition: The process of synaptic transmission from a neuron to another neuron across a synapse.
Synonyms: nerve-nerve synaptic transmission
synaptic transmission, cholinergic (GO:0007271)
Namespace: biological_process
Definition: The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms: cholinergic synaptic transmission
ensheathment of neurons (GO:0007272)
Namespace: biological_process
Definition: The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.
Synonyms: ionic insulation of neurons by glial cells
obsolete regulation of synapse (GO:0007273)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: regulation of synapse
Comment: This term was made obsolete because the term string made no sense.
neuromuscular synaptic transmission (GO:0007274)
Namespace: biological_process
Definition: The process of synaptic transmission from a neuron to a muscle, across a synapse.
multicellular organism development (GO:0007275)
Namespace: biological_process
Definition: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Comment: Note that this term was 'developmental process'.
gamete generation (GO:0007276)
Namespace: biological_process
Definition: The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
Synonyms: gametogenesis
pole cell development (GO:0007277)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure.
pole cell fate determination (GO:0007278)
Namespace: biological_process
Definition: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed.
pole cell formation (GO:0007279)
Namespace: biological_process
Definition: Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
Comment: See also the Cell Ontology term 'pole cell ; CL:0000301'.
obsolete pole cell migration (GO:0007280)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
Comment: The reason for obsoletion is that the term is unnecessarily taxon-specific.
germ cell development (GO:0007281)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
Synonyms: gametogenesis; germ-cell development; primordial germ cell development
cystoblast division (GO:0007282)
Namespace: biological_process
Definition: Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells.
Synonyms: cystoblast cell division
spermatogenesis (GO:0007283)
Namespace: biological_process
Definition: The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
Synonyms: generation of spermatozoa
spermatogonial cell division (GO:0007284)
Namespace: biological_process
Definition: The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes).
Synonyms: spermatogonium division
Comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'.
primary spermatocyte growth (GO:0007285)
Namespace: biological_process
Definition: The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis.
spermatid development (GO:0007286)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
Synonyms: spermatid cell development; spermiogenesis
Nebenkern assembly (GO:0007287)
Namespace: biological_process
Definition: Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern.
Synonyms: Nebenkern formation
Comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'.
sperm axoneme assembly (GO:0007288)
Namespace: biological_process
Definition: The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
spermatid nucleus differentiation (GO:0007289)
Namespace: biological_process
Definition: The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.
Synonyms: spermatid nuclear differentiation
Comment: See also the Cell Ontology term 'spermatid ; CL:0000018'.
spermatid nucleus elongation (GO:0007290)
Namespace: biological_process
Definition: The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation.
Synonyms: spermatid nuclear elongation
sperm individualization (GO:0007291)
Namespace: biological_process
Definition: The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.
female gamete generation (GO:0007292)
Namespace: biological_process
Definition: Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
germarium-derived egg chamber formation (GO:0007293)
Namespace: biological_process
Definition: Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
germarium-derived oocyte fate determination (GO:0007294)
Namespace: biological_process
Definition: The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster.
Synonyms: maintenance of oocyte identity; oocyte cell fate determination
vitellogenesis (GO:0007296)
Namespace: biological_process
Definition: The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.
Synonyms: yolk formation; yolk production
follicle cell of egg chamber migration (GO:0007297)
Namespace: biological_process
Definition: The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster.
Synonyms: follicle cell migration
border follicle cell migration (GO:0007298)
Namespace: biological_process
Definition: The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
Synonyms: border cell migration
follicle cell of egg chamber-cell adhesion (GO:0007299)
Namespace: biological_process
Definition: The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster.
Synonyms: follicle cell adhesion; ovarian follicle cell adhesion
ovarian nurse cell to oocyte transport (GO:0007300)
Namespace: biological_process
Definition: Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.
Synonyms: nurse cell to oocyte transport
female germline ring canal formation (GO:0007301)
Namespace: biological_process
Definition: Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
Synonyms: nurse cell ring canal formation; ovarian ring canal formation
nurse cell nucleus anchoring (GO:0007302)
Namespace: biological_process
Definition: Attachment of the nurse cell nucleus to the plasma membrane.
obsolete cytoplasmic transport, nurse cell to oocyte (GO:0007303)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
chorion-containing eggshell formation (GO:0007304)
Namespace: biological_process
Definition: The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster.
Synonyms: eggshell formation
vitelline membrane formation involved in chorion-containing eggshell formation (GO:0007305)
Namespace: biological_process
Definition: Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster.
Synonyms: vitelline membrane formation in chorion-containing eggshell
egg chorion assembly (GO:0007306)
Namespace: biological_process
Definition: Construction of the chorion portion of the egg, which is a protective, noncellular membrane that surrounds the eggs of various animals including insects and fish.
Synonyms: eggshell chorion formation; insect chorion formation
eggshell chorion gene amplification (GO:0007307)
Namespace: biological_process
Definition: Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster.
oocyte construction (GO:0007308)
Namespace: biological_process
Definition: The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.
Synonyms: oocyte arrangement
oocyte axis specification (GO:0007309)
Namespace: biological_process
Definition: The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.
Synonyms: oocyte axis determination
oocyte dorsal/ventral axis specification (GO:0007310)
Namespace: biological_process
Definition: The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.
Synonyms: oocyte dorsal-ventral axis specification; oocyte dorsal/ventral axis determination; oocyte dorsoventral axis specification
maternal specification of dorsal/ventral axis, oocyte, germ-line encoded (GO:0007311)
Namespace: biological_process
Definition: Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster.
Synonyms: maternal determination of dorsal/ventral axis, oocyte, germ-line encoded; maternal specification of dorsal-ventral axis, oocyte, germ-line encoded; maternal specification of dorsoventral axis, oocyte, germ-line encoded