LiteFold/GO huggingface dataset:
dopamine loading into synaptic vesicle (GO:0160310)
Namespace: biological_process
Definition: The active transport of dopamine neurotransmitters into a synaptic vesicle.
tyramine loading into synaptic vesicle (GO:0160311)
Namespace: biological_process
Definition: The active transport of tyramine neurotransmitters into a synaptic vesicle.
endosomal intralumenal vesicle (GO:0160313)
Namespace: cellular_component
Definition: A membrane-bounded vesicle that is located within the lumen of an endosome.
Synonyms: ILV
endosomal intralumenal vesicle membrane (GO:0160314)
Namespace: cellular_component
Definition: The lipid bilayer surrounding an intraluminal vesicle within an endososome.
Synonyms: endosome ILV membrane; endosome internal vesicle membrane
endosomal intralumenal vesicle lumen (GO:0160315)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of an intraluminal vesicle within an endosome.
Synonyms: endosome ILV lumen; endosome internal vesicle lumen
endolysosomal intralumenal vesicle (GO:0160316)
Namespace: cellular_component
Definition: A membrane-bounded vesicle that is located within the lumen of an endolysosome.
Synonyms: endolysosomal ILV
endolysosomal intralumenal vesicle membrane (GO:0160317)
Namespace: cellular_component
Definition: The lipid bilayer surrounding an intraluminal vesicle within an endolysosome.
Synonyms: endolysosome ILV membrane; endolysosome internal vesicle membrane
endolysosomal intralumenal vesicle lumen (GO:0160318)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of an intraluminal vesicle within an endolysosome.
Synonyms: endolysosome ILV lumen; endolysosome internal vesicle lumen
lipoyl-dependent peroxiredoxin activity (GO:0160319)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O.
obsolete protein-tyrosine iodotransferase activity (GO:0160320)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: [thyroglobulin]-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O and [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.
Comment: The reason for obsoletion is that the reactions covered by this term (RHEA:48956 and RHEA:48960) are now subsumed by the updated GO:0004447 (iodide peroxidase activity), which covers all 5 thyroid peroxidase reactions.
halotropism (GO:0170002)
Namespace: biological_process
Definition: A sodium-specific negative tropism that is crucial for surviving and thriving under high salinity.
Synonyms: root halotropism
lipoate transmembrane transporter activity (GO:0170004)
Namespace: molecular_function
Definition: Enables the transfer of lipoate from one side of a membrane to the other.
cyclic nucleotide phosphodiesterase activator activity (GO:0170005)
Namespace: molecular_function
Definition: Binds to and increases the activity of cyclic nucleotide phosphodiesterase.
lipoate transmembrane transport (GO:0170006)
Namespace: biological_process
Definition: The process in which lipoate is transported across a membrane.
endoplasmic reticulum-lipid droplet tether activity (GO:0170007)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a lipid droplet with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication.
mRNA phosphatase activator activity (GO:0170008)
Namespace: molecular_function
Definition: Binds to and increases the activity of mRNA phosphatase.
endoplasmic reticulum-organelle membrane tether activity (GO:0170009)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain membrane contact sites and mediate organelle exchange and communication.
nonsense-mediated decay complex (GO:0170010)
Namespace: cellular_component
Definition: A highly conserved protein complex that recognises and elicits the rapid degradation of mRNAs in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
Synonyms: Upf complex
stalled ribosome sensor activity (GO:0170011)
Namespace: molecular_function
Definition: A molecule that recognizes stalled ribosomes and initiates a signaling response.
histone H3K18 decrotonylase activity (GO:0170012)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide.
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
channel complex (GO:0170013)
Namespace: cellular_component
Definition: A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
ankyrin-1 complex (GO:0170014)
Namespace: cellular_component
Definition: A complex composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1, that functions in the stability and shape of the erythrocyte membrane in human.
Synonyms: ankyrin complex; erythrocyte ankyrin-1 complex
carbon dioxide receptor activity (GO:0170015)
Namespace: molecular_function
Definition: Combining with carbon dioxide to initiate a change in cell activity.
endoplasmic reticulum-endosome tether activity (GO:0170016)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.
ionotropic olfactory receptor activity (GO:0170020)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific odorant has been bound by the channel complex or one of its constituent parts.
ionotropic taste receptor activity (GO:0170021)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a soluble compound has been bound by the channel complex or one of its constituent parts.
ionotropic bitter taste receptor activity (GO:0170022)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific bitter compound has been bound by the channel complex or one of its constituent parts.
ionotropic sweet taste receptor activity (GO:0170023)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when a specific soluble sweet compound has been bound by the channel complex or one of its constituent parts.
SKA complex (GO:0170027)
Namespace: cellular_component
Definition: An outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis. In humans, it contains the subunits SKA1, SKA2 and SKA3.
Synonyms: SKA1 complex
L-amino acid metabolic process (GO:0170033)
Namespace: biological_process
Definition: The chemical reactions and pathways involving an L-amino acid.
Synonyms: L-alpha-amino acid metabolism; L-amino acid metabolism
L-amino acid biosynthetic process (GO:0170034)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids.
Synonyms: L-amino acid anabolism; L-amino acid biosynthesis; L-amino acid formation; L-amino acid synthesis
L-amino acid catabolic process (GO:0170035)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of an L-amino acid.
Synonyms: L-amino acid breakdown; L-amino acid catabolism; L-amino acid degradation
import into the mitochondrion (GO:0170036)
Namespace: biological_process
Definition: The directed movement of substances from the cytosol into the mitochondrion.
proteinogenic amino acid biosynthetic process (GO:0170038)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
Synonyms: proteinogenic amino acid anabolism; proteinogenic amino acid biosynthesis; proteinogenic amino acid formation; proteinogenic amino acid synthesis
proteinogenic amino acid metabolic process (GO:0170039)
Namespace: biological_process
Definition: The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
Synonyms: proteinogenic amino acid metabolism
proteinogenic amino acid catabolic process (GO:0170040)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
Synonyms: proteinogenic amino acid breakdown; proteinogenic amino acid catabolism; proteinogenic amino acid degradation
non-proteinogenic amino acid metabolic process (GO:0170041)
Namespace: biological_process
Definition: The chemical reactions and pathways involving non-proteingenic amino acids.
Synonyms: non-proteinogenic amino acid metabolism
non-proteinogenic amino acid biosynthetic process (GO:0170043)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids.
Synonyms: non-proteinogenic amino acid anabolism; non-proteinogenic amino acid formation; non-proteinogenic amino acid synthesis; non-proteinogenic biosynthesis
non-proteinogenic amino acid catabolic process (GO:0170044)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids.
Synonyms: non-proteinogenic amino acid breakdown; non-proteinogenic amino acid catabolism; non-proteinogenic amino acid degradation
isopentenyl pyrophosphate import into mitochondrion (GO:0170046)
Namespace: biological_process
Definition: The process in which isopentenyl pyrophosphate is transported across a membrane into the mitochondrion.
virus-like capsid (GO:0170047)
Namespace: cellular_component
Definition: A protein coat that surrounds nucleic acid to form a structure similar to a virus capsid. Virus-like capsids are non-infectious and are encoded by endogenous (non-viral) genes. Fly and tetrapod Arc (ancestrally-related to retrotransposon Gag) are examples of proteins that can self-assemble into capsid-like structures which encapsulate Arc mRNA and mediate the intercellular transmission of RNA.
Synonyms: virus-like particle
D-alanine import across plasma membrane (GO:0170048)
Namespace: biological_process
Definition: The directed import of D-alanine from the extracellular region across the plasma membrane and into the cytosol.
Synonyms: D-alanine import; D-alanine import into cell; D-alanine uptake
box C/D RNP complex (GO:0170049)
Namespace: cellular_component
Definition: A ribonucleoprotein complex consisting of a box C/D type snRNA and three (Archaea) or four (Eukaryotes) core proteins that have diverse functions, including site-specific methylation of rRNA and processing rRNA.
Synonyms: SNORD ribonucleoprotein complex; SNORNP
box C/D methylation guide RNP complex (GO:0170050)
Namespace: cellular_component
Definition: A ribonucleoprotein complex containing a box C/D type snoRNA and three (Archaea) or four (Eukaryotes) core proteins that is capable of methylation of target RNAs.
box C/D methylation guide scaRNP complex (GO:0170051)
Namespace: cellular_component
Definition: A ribonucleoprotein complex containing a small CB-specific RNA (scaRNA), with a short sequence motif (GU/UG wobble stem) for CB localization that is capable of methylation of target RNAs.
box C/D pre-rRNA cleavage RNP complex (GO:0170052)
Namespace: cellular_component
Definition: A ribonucleoprotein complex containing a box C/D type RNA that is involved in pre-rRNA cleavage.
nuclease activator activity (GO:0170053)
Namespace: molecular_function
Definition: Binds to and increases the activity of a nuclease.
ribonuclease activator activity (GO:0170054)
Namespace: molecular_function
Definition: Binds to and increases the activity of a ribonuclease.
Synonyms: RNA nuclease activator activity
lipid transmembrane transporter activity (GO:0170055)
Namespace: molecular_function
Definition: Enables the transfer of a lipid from one side of a membrane to the other.
cholesterol 7-desaturase [NAD(P)H] activity (GO:0170056)
Namespace: molecular_function
Definition: Catalysis of the reaction: cholesterol + H+ + NAD(P)H + O2 = 7-dehydrocholesterol + 2 H2O + NAD(P)+.
Synonyms: C-7 cholesterol dehydrogenase; cholesterol 7,8-dehydrogenase
RNA ligase (GTP) activity (GO:0170057)
Namespace: molecular_function
Definition: Catalysis of the joining of an RNA with 3'-phosphate or 2',3'-cyclic-phosphate ends to an RNA with 5'-hydroxy ends according to either (i) a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP; or (ii) a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H+.
Synonyms: 3'-phosphate/5'-hydroxy nucleic acid ligase activity
microtubule destabilizing activity (GO:0170060)
Namespace: molecular_function
Definition: A protein-containing complex destabilizing activity that promotes microtubule catastrophe (transition from microtubule growth to microtubule shrinkage).
Synonyms: microtubule catastrophe inducing activity; microtubule catastrophe promoting activity
nutrient storage (GO:0170062)
Namespace: biological_process
Definition: The accumulation and maintenance in cells or tissues of a nutrient, a substance that is used by an organism to survive, to grow, and to reproduce; such as proteins, vitamins, and minerals. Nutrient reserves can be accumulated for mobilization and utilization when needed.
transmembrane transport from lysosomal lumen to cytosol (GO:0170063)
Namespace: biological_process
Definition: The directed movement of a solute from the lysosomal lumen across the lysosomal membrane and into the cytosol.
Synonyms: export from lysosome lumen to cytosol
lysosome fission (GO:0170064)
Namespace: biological_process
Definition: The process by which lysosomes undergo budding and fission to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration.
negative regulation of polyamine biosynthetic process (GO:0170066)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups.
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline (GO:0170067)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound N-acetyl-L-citrulline.
Synonyms: arginine biosynthesis via N-acetyl intermediates; arginine biosynthesis, N-acetylated pathway
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
geranylgeranyltransferase-III complex (GO:0170069)
Namespace: cellular_component
Definition: A protein-containing complex that catalyzes the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a mono-farnsylated substrate. In humans, the complex is comprised of a prenyltransferase alpha subunit, PTAR1 and beta subunit, RabGGTB, while in budding yeast the prenyltransferase complex contains Ecm9p, the alpha subunit and Bet2p, the beta subunit.
Synonyms: geranylgeranyltransferase type 3 complex; geranylgeranyltransferase type-3 complex; GGT3; GGTase-3 complex; GGTase-III complex; GGTase3 complex; type-III geranylgeranyltransferase complex
negative regulation of mitochondrial transcription (GO:0170070)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription occurring in the mitochondrion.
CROP complex (GO:0170071)
Namespace: cellular_component
Definition: A complex involved in membrane fission during protein exchange in endo-lysosomal compartments. CROP joins members of two protein families: the peripheral subunits of retromer, a coat forming endosomal transport carriers, and membrane inserting PROPPINs.
Synonyms: Cutting Retromer-On-PROPPIN
RADAR pathway (GO:0170074)
Namespace: biological_process
Definition: A quality control pathway that degrades peroxisomal matrix protein receptors when the recycling machinery is blocked. When recycling to the cytosol fails, cargo-free receptors accumulate at the peroxisomal membrane, where they are polyubiquitinated and subsequently degraded by the ubiquitin-proteasome system (UPS).
Synonyms: Receptor Accumulation and Degradation in the Absence of Recycling
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay (GO:0170075)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, no-go decay.
Synonyms: negative regulation of no-go decay; negative regulation of no-go mRNA decay; negative regulation of nuclear-transcribed mRNA breakdown, no-go decay; negative regulation of nuclear-transcribed mRNA catabolism, no-go decay; negative regulation of nuclear-transcribed mRNA degradation, no-go decay
histone methyltransferase inhibitor activity (GO:0180000)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a histone methyltransferase.
cyclic-di-AMP binding (GO:0180001)
Namespace: molecular_function
Definition: Binding to a cyclic di-AMP nucleotide.
Synonyms: cyclic dimeric adenosine monophosphate binding
renal zinc excretion (GO:0180002)
Namespace: biological_process
Definition: The elimination of zinc ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.
Synonyms: renal zinc ion excretion; renal zinc secretion
S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity (GO:0180003)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out).
RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity (GO:0180004)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate.
Synonyms: RNA polymerase II C-terminal domain Y1 phosphatase activity
RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity (GO:0180005)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-threonine (consensus YSPTSPS)(position 4) + H2O = RNA polymerase II large subunit + phosphate.
Synonyms: RNA polymerase II C-terminal domain T4 phosphatase activity
RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity (GO:0180006)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate.
Synonyms: RNA polymerase II C-terminal domain S2 phosphatase activity
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (GO:0180007)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate.
Synonyms: RNA polymerase II C-terminal domain S5 phosphatase activity
RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity (GO:0180008)
Namespace: molecular_function
Definition: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate.
Synonyms: RNA polymerase II C-terminal domain S7 phosphatase activity
broad specificity neutral L-amino acid:basic L-amino acid antiporter activity (GO:0180009)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out).
Synonyms: neutral L-amino acid:cationic L-amino acid antiporter activity; neutral L-amino acid:dibasic L-amino acid antiporter activity; neutral L-amino acid:positively-charged polar L-amino acid antiporter activity; system b(0,+)-type activity
co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway (GO:0180010)
Namespace: biological_process
Definition: Any process involved in transcription termination-coupled 3' processing of RNA polymerase II mRNA transcripts by the 3' end cleavage and addition of a poly(A) tail.
Synonyms: cotranscriptional 3' processing of RNA polymerase II mRNA transcripts; mRNA polyadenylation
co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway (GO:0180012)
Namespace: biological_process
Definition: Any process involved in transcription termination-coupled 3' processing of RNA polymerase II RNA transcripts by 3' end cleavage and addition of a poly(A) tail.
Synonyms: cotranscriptional 3'-end processing of RNA polymerase II transcripts
lysophosphatidylserine flippase activity (GO:0180013)
Namespace: molecular_function
Definition: Catalysis of the movement of a lysophosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
protein-tRNA adaptor activity (GO:0180014)
Namespace: molecular_function
Definition: The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way.
Synonyms: tRNA carrier
nucleoside import across plasma membrane (GO:0180015)
Namespace: biological_process
Definition: The directed movement of nucleoside from outside of a cell, across the plasma membrane and into the cytosol.
SUMO ligase regulator activity (GO:0180016)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a SUMO ligase.
cytoplasmic polyadenylation-dependent RNA catabolic process (GO:0180018)
Namespace: biological_process
Definition: The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate.