LiteFold/GO huggingface dataset:
von-Willerbrand-factor-A-domain-rich collagen trimer (GO:0140158)
Namespace: cellular_component
Definition: A family of collagens containing multiple von Willebrand factor A (vWA) domains.
borate export across plasma membrane (GO:0140159)
Namespace: biological_process
Definition: The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region.
monocarboxylate:sodium symporter activity (GO:0140161)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in).
venom-mediated vasodilation by activation of bradykinin receptor signaling pathway (GO:0140162)
Namespace: biological_process
Definition: A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates bradykinin-dependent signaling, concomittantly reducing blood pressure in the bitten/stung organism. This can take place via several mechanisms that affect endogenous bradykinin: either increasing its release by kallikrein-like proteases, increasing bradykinin action by potentiation, or inhibiting bradykinin degradation.
Synonyms: venom-mediated vasodilation by activation of bradykinin-dependent signaling; venom-mediated vasodilation through activity of bradykinin
venom-mediated suppression of bradykinin-dependent vasodilation (GO:0140163)
Namespace: biological_process
Definition: A process in which an organism inhibits or disrupts vasodilation via the action of a venom that suppresses bradykinin-dependent signaling.
Synonyms: venom-mediated vasoconstriction via bradykinin receptor antagonism
COG complex binding (GO:0140164)
Namespace: molecular_function
Definition: Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family.
Synonyms: Golgi transport complex binding
venom-mediated vasodilation by activation of nitric oxide-cGMP-mediated signaling (GO:0140165)
Namespace: biological_process
Definition: A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates nitric oxide-cGMP-mediated signaling, concomittantly reducing blood pressure in the bitten/stung organism.
Synonyms: venom-mediated vasodilation induced by nitric oxide activity
venom-mediated vasodilation via suppression of angiotensin maturation (GO:0140166)
Namespace: biological_process
Definition: A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that prevents angiotensin maturation, concomittantly reducing blood pressure in the bitten/stung organism.
Synonyms: venom-mediated vasodilation mediated by inhibition of angiotensin-converting enzyme; venom-mediated vasodilation through perturbation of angiotensin maturation
histone locus body assembly (GO:0140167)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a histone locus body.
nuclear ribonucleoprotein granule (GO:0140168)
Namespace: cellular_component
Definition: A ribonucleoprotein granule located in the nucleus.
Synonyms: nuclear RNA granule; nuclear RNP granule
3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity (GO:0140169)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+.
Comment: Note that EC distinguishes stereospecific reactions: EC:1.1.1.213 and EC:1.1.1.50. These are out of scope for GO.
D-lactate dehydrogenase (FAD) activity (GO:0140170)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-lactate + FAD + H+ = FADH2 + pyruvate.
L-lactate dehydrogenase activity (GO:0140171)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-lactate + A = AH(2) + pyruvate.
histone H2AT120pho reader activity (GO:0140172)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H2A phosphorylated at threonine 120.
Synonyms: histone H2AS120pho reader activity
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes, but corresponds to T119 in Drosophila and S121 in yeast and Tetrahymena. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H2AS139pho reader activity (GO:0140173)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H2A phosphorylated at serine 139.
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. This corresponds to H2AS128 in S. pombe and H2AS129 in S. cerevisiae.
(2R)-2-hydroxyacid dehydrogenase (NAD+) activity (GO:0140175)
Namespace: molecular_function
Definition: Catalysis of the reaction: a (2R)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+.
positive regulation of pyruvate decarboxylation to acetyl-CoA (GO:0140176)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions.
membrane-membrane adaptor activity (GO:0140177)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.
lumenal side of cis-Golgi network membrane (GO:0140178)
Namespace: cellular_component
Definition: The leaflet of the cis-Golgi network membrane directly contacts the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where glycosylation, cargo sorting, or interactions with resident Golgi proteins occur.
cytoplasmic side of cis-Golgi network membrane (GO:0140179)
Namespace: cellular_component
Definition: The leaflet of the cis-Golgi network membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site of interactions with cytosolic proteins, including those for vesicle tethering, fusion, and Golgi-associated trafficking activities.
centriole scaffold activity (GO:0140180)
Namespace: molecular_function
Definition: The binding activity of a protein that contributes to the stable formation of a centriole by forming persistent structures, or templates, upon which other centriolar proteins assemble.
host-mediated activation of viral RNA-templated transcription (GO:0140181)
Namespace: biological_process
Definition: A process in which a host organism initiates, promotes, or enhances the normal execution of viral RNA-templated transcription, the synthesis of either RNA on a RNA template.
Synonyms: positive regulation by host of viral RNA-templated transcription; positive regulation of viral RNA-templated transcription by host
recycling of RNA polymerase (GO:0140182)
Namespace: biological_process
Definition: The process of freeing aborted or stalled RNA polymerase (RNAP), which dissociates it from nucleic acids and allows RNAP to reinitiate another transcription cycle. The freed mRNA is not used for further transcription.
venom-mediated vasoconstriction via activation of endothelin receptor signaling pathway (GO:0140183)
Namespace: biological_process
Definition: A process in which an organism promotes the narrowing (constriction) of blood vessels, by inhibiting the widening (dilation) of blood vessels in another organism via the action of a venom that activates endothelin receptor signaling pathway, concomittantly increasing blood pressure in the bitten/stung organism.
Synonyms: venom-mediated vasoconstriction via activation of endothelin signaling pathway; venom-mediated vasoconstriction via activation of endothelin-dependent signaling; venom-mediated vasoconstriction via endothelin receptor agonism
siRNA-mediated silent mating type cassette region heterochromatin formation (GO:0140185)
Namespace: biological_process
Definition: The formation of heterochromatin into a heterochromatin domain by a process mediated by a small interfering siRNA at the silent mating-type loci.
Synonyms: siRNA mediated silent mating type cassette region heterochromatin formation; siRNA-mediated silent-mating type cassette region heterochromatin formation
protein N-acyltransferase activity (GO:0140186)
Namespace: molecular_function
Definition: Catalysis of the reaction: an acyl-CoA + L-lysyl-[protein] = N6-acyl-L-lysyl-[protein] + CoA + H+.
Synonyms: protein acyltransferase activity
histone H1-4K34 acetyltransferase activity (GO:0140187)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + histone H1-4 L-lysine (position 34) = CoA + histone H1-4 N6-acetyl-L-lysine (position 34).
histone H1 methyltransferase activity (GO:0140188)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H1 = S-adenosyl-L-homocysteine + a methylated histone H1.
Synonyms: histone H1 methylase activity; histone H1 methylation
H1-4K26 methyltransferase activity (GO:0140189)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + histone H1-4 L-lysine (position 26) = S-adenosyl-L-homocysteine + histone H1-4 N6-methyl-L-lysine (position 26).
histone H1 kinase activity (GO:0140190)
Namespace: molecular_function
Definition: Catalysis of the transfer of a phosphate group to a histone H1.
histone H1-4S187 kinase activity (GO:0140191)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H1-4-serine (position 27) + ATP = histone H1-4-phosphoserine (position 27) + ADP.
obsolete regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process (GO:0140192)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
Comment: This term was obsoleted because it represents a GO-CAM pathway.
obsolete regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process (GO:0140193)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process.
Comment: This term was obsoleted because it represents a GO-CAM pathway.
obsolete negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process (GO:0140194)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process.
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process (GO:0140195)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process.
Comment: This term was obsoleted because it represents a GO-CAM pathway.
obsolete positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process (GO:0140196)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
histone H1-4S27 kinase activity (GO:0140197)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H1-4-serine (position 187) + ATP = histone H1-4-phosphoserine (position 187) + ADP.
histone H1-4S35 kinase activity (GO:0140198)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H1-4-serine (position 35) + ATP = histone H1-4-phosphoserine (position 35) + ADP.
obsolete negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process (GO:0140199)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate (GO:0140200)
Namespace: biological_process
Definition: OBSOLETE. An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction.
Comment: This term was obsoleted because it represents a GO-CAM pathway.
urea import across plasma membrane (GO:0140201)
Namespace: biological_process
Definition: The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol.
polyamine import across plasma membrane (GO:0140202)
Namespace: biological_process
Definition: The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol.
spermidine import across plasma membrane (GO:0140203)
Namespace: biological_process
Definition: The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol.
pyridoxal import across plasma membrane (GO:0140204)
Namespace: biological_process
Definition: The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol.
oligopeptide import across plasma membrane (GO:0140205)
Namespace: biological_process
Definition: The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol.
dipeptide import across plasma membrane (GO:0140206)
Namespace: biological_process
Definition: The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol.
tripeptide import across plasma membrane (GO:0140207)
Namespace: biological_process
Definition: The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol.
apoptotic process in response to mitochondrial fragmentation (GO:0140208)
Namespace: biological_process
Definition: Any apoptotic process that occurs as a result of mitochondrial fragmentation.
Synonyms: apoptosis in response to mitochondrial fragmentation
zinc ion import into endoplasmic reticulum (GO:0140209)
Namespace: biological_process
Definition: The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum.
Synonyms: zinc ion import across endoplasmic reticulum; zinc ion import into ER; zinc(2+) import across endoplasmic reticulum; zinc(2+) import into endoplasmic reticulum
Comment: This term covers zinc(2+) import *across* the endoplasmic reticulum membrane through a channel or pore. It does not cover import via vesicle fusion with endoplasmic reticulum membrane, as in this case transport does not involve crossing the membrane.
protein transport along microtubule to kinetochore (GO:0140210)
Namespace: biological_process
Definition: Any process in which a protein is transported to the kinetochore along a microtubule.
folic acid:proton symporter activity (GO:0140211)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid.
regulation of long-chain fatty acid import into cell (GO:0140212)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell.
negative regulation of long-chain fatty acid import into cell (GO:0140213)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell.
positive regulation of long-chain fatty acid import into cell (GO:0140214)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell.
regulation of D-aspartate import across plasma membrane (GO:0140215)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
negative regulation of D-aspartate import across plasma membrane (GO:0140216)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
positive regulation of D-aspartate import across plasma membrane (GO:0140217)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
histone methacryltransferase activity (GO:0140218)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-methylpropenoyl-CoA + L-lysyl-[protein] = N6-methacrylyl-L-lysyl-[protein] + CoA + H+. Methacryl-CoA is a synonym of 2-methylpropenoyl-CoA.
Synonyms: histone 2-methylpropenoyl transferase activity
histone methacryllysine demethacrylase activity (GO:0140219)
Namespace: molecular_function
Definition: Catalysis of the reaction: N6-methacrylyl-L-lysyl-[histone] + H2O = 2-methylprop-2-enoate + L-lysyl-[histone].
pathogen-containing vacuole (GO:0140220)
Namespace: cellular_component
Definition: A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides.
Synonyms: pathogen inclusion; pathogen-containing compartment
pathogen-containing vacuole membrane (GO:0140221)
Namespace: cellular_component
Definition: Host-derived membrane of a pathogen-containing vacuole.
Synonyms: pathogen inclusion membrane; pathogen-containing compartment membrane
pathogen-containing vacuole lumen (GO:0140222)
Namespace: cellular_component
Definition: The enclosed volume within the sealed membrane of a pathogen-containing vacuole.
Synonyms: lumen of a pathogen-containing vacuole; pathogen inclusion lumen; pathogen-containing compartment lumen; pathogen-containing vacuolar lumen
general transcription initiation factor activity (GO:0140223)
Namespace: molecular_function
Definition: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
Synonyms: basal transcription factor activity; general transcription factor activity; GTF activity
Comment: Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.
SLAC complex (GO:0140224)
Namespace: cellular_component
Definition: A protein complex that regulates Arp2/3 complex-mediated actin nucleation.
DNA topoisomerase III-beta-TDRD3 complex (GO:0140225)
Namespace: cellular_component
Definition: A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities.
Synonyms: Top3-beta-TDRD3 complex
RNA topoisomerase activity (GO:0140226)
Namespace: molecular_function
Definition: Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA.
serotonin-gated cation-selective signaling pathway (GO:0140227)
Namespace: biological_process
Definition: The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms: 5-HT-gated cation-selective signaling pathway; 5-HT-gated cation-selective signalling pathway; 5-hydroxytryptamine-gated cation-selective signaling pathway; 5-hydroxytryptamine-gated cation-selective signalling pathway; serotonin-gated cation-selective signalling pathway
histone benzoyllysine debenzoylase activity (GO:0140228)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-benzoyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-benzoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein].
histone isonicotinyllysine deisonicotinylase activity (GO:0140229)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-isonicotinyl-L-lysyl-[protein] + H2O = isonicotinate + L-lysyl-[protein].
histone isonicotinyltransferase activity (GO:0140230)
Namespace: molecular_function
Definition: Catalysis of the reaction: isonicotinyl-CoA + histone = coA + N(6)-isonicotinyl-histone.
anterograde axonal transport of neurotransmitter receptor complex (GO:0140231)
Namespace: biological_process
Definition: The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.
obsolete intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential (GO:0140232)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.
Synonyms: intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
obsolete intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential (GO:0140233)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.
Synonyms: intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.