LiteFold/GO huggingface dataset:
obsolete high affinity metal ion uptake transporter activity (GO:0015336)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+.
Synonyms: high affinity metal ion uptake transporter activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
obsolete low affinity metal ion uptake transporter activity (GO:0015337)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+.
Synonyms: low affinity metal ion uptake transporter activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
obsolete cobalt, zinc uptake permease activity (GO:0015339)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport.
Synonyms: cobalt, zinc uptake permease activity
Comment: This term was made obsolete because it represents more than one molecular function.
obsolete zinc, cadmium uptake permease activity (GO:0015340)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport.
Synonyms: zinc, cadmium uptake permease activity
Comment: This term was made obsolete because it represents more than one molecular function.
zinc efflux antiporter activity (GO:0015341)
Namespace: molecular_function
Definition: Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane according to the reaction H+(out) + Zn2+(in) = H+(in) + Zn2+(out). The activity is driven by proton motive force.
Synonyms: zinc efflux permease activity
obsolete zinc, iron permease activity (GO:0015342)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force.
Synonyms: zinc, iron permease activity
Comment: This term was made obsolete because it represents more than one molecular function.
siderophore-iron transmembrane transporter activity (GO:0015343)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).
Synonyms: iron-siderophore transporter activity; siderochrome transporter activity; siderochrome-iron transporter activity; siderophore transmembrane transporter activity; siderophore transporter activity; siderophore-iron transporter activity
siderophore uptake transmembrane transporter activity (GO:0015344)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in).
Synonyms: ferrioxamine uptake transmembrane transporter activity; siderochrome-iron (ferrioxamine) uptake transporter; siderophore-iron uptake transmembrane transporter activity
ferric enterobactin:proton symporter activity (GO:0015345)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in).
Synonyms: ferric enterobactin:hydrogen symporter activity; ferric-enterobactin:proton symporter activity
ferric triacetylfusarinine C:proton symporter activity (GO:0015346)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in).
Synonyms: ferric triacetylfusarinine C:hydrogen symporter activity
obsolete sodium-independent organic anion transmembrane transporter activity (GO:0015347)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner.
Comment: The reason for obsoletion is that this term was an unnecessary and confusing grouping term.
obsolete prostaglandin/thromboxane transporter activity (GO:0015348)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: prostaglandin/thromboxane transporter activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
thyroid hormone transmembrane transporter activity (GO:0015349)
Namespace: molecular_function
Definition: Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
methotrexate transmembrane transporter activity (GO:0015350)
Namespace: molecular_function
Definition: Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
Synonyms: methotrexate transporter activity
obsolete bilirubin secondary active transmembrane transporter activity (GO:0015351)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: bilirubin porter activity; bilitranslocase
Comment: This term was obsoleted because it does not define a specific transport mechanism.
obsolete secondary active sterol transmembrane transporter activity (GO:0015352)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of sterol from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
Synonyms: sterol porter activity
Comment: This term was obsoleted because there is no evidence that this function exists.
secondary active monocarboxylate transmembrane transporter activity (GO:0015355)
Namespace: molecular_function
Definition: Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.
Synonyms: monocarboxylate porter activity
obsolete monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity (GO:0015356)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
obsolete amino acid/choline transmembrane transporter activity (GO:0015358)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: amino acid/choline transmembrane transporter activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
acetate:proton symporter activity (GO:0015360)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in).
Synonyms: acetate:hydrogen symporter activity; hydrogen:acetate symporter activity
high-affinity sodium:dicarboxylate symporter activity (GO:0015362)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity sodium:dicarboxylate cotransporter activity; high affinity sodium:dicarboxylate symporter activity
dicarboxylate:phosphate antiporter activity (GO:0015364)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + phosphate(in) = dicarboxylate(in) +  phosphate(out).
Synonyms: dicarboxylate:inorganic phosphate antiporter activity
malate:proton symporter activity (GO:0015366)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in).
Synonyms: L-malic acid permease; L-malic acid:proton symporter activity; malate permease; malate:hydrogen symporter activity
oxoglutarate:malate antiporter activity (GO:0015367)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out).
Synonyms: 2-oxoglutarate/malate carrier protein
calcium:monoatomic cation antiporter activity (GO:0015368)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in).
Synonyms: calcium:cation antiporter activity
calcium:proton antiporter activity (GO:0015369)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).
Synonyms: calcium:hydrogen antiporter activity
solute:sodium symporter activity (GO:0015370)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).
Synonyms: proline/glycine/betaine:hydrogen/sodium symporter activity
obsolete glutamate/aspartate:sodium symporter activity (GO:0015372)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in).
Synonyms: glutamate/aspartate:sodium symporter activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
monoatomic anion:sodium symporter activity (GO:0015373)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in).
Synonyms: anion:sodium symporter activity; monovalent anion:sodium symporter activity
neutral, basic amino acid:sodium:chloride symporter activity (GO:0015374)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in).
Synonyms: neutral, cationic amino acid:sodium:chloride symporter activity
glycine:sodium symporter activity (GO:0015375)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in).
sodium:chloride symporter activity (GO:0015378)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in).
potassium:chloride symporter activity (GO:0015379)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
Synonyms: potassium ion symporter activity
high-affinity sulfate transmembrane transporter activity (GO:0015381)
Namespace: molecular_function
Definition: Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations.
Synonyms: high affinity sulfate permease activity; high affinity sulfate transmembrane transporter activity; high affinity sulphate permease activity
sodium:sulfate symporter activity (GO:0015382)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in).
Synonyms: sodium:sulfate cotransporter activity; sodium:sulphate symporter activity
sulfate:bicarbonate antiporter activity (GO:0015383)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out).
Synonyms: sulfate:hydrogencarbonate antiporter activity; sulphate:bicarbonate antiporter activity
sodium:proton antiporter activity (GO:0015385)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Synonyms: pH-dependent sodium:hydrogen antiporter activity; pH-dependent sodium:proton antiporter activity; sodium/hydrogen antiporter activity; sodium:hydrogen antiporter activity; sodium:hydrogen exchange activity; sodium:hydrogen exchanger
potassium:proton antiporter activity (GO:0015386)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
Synonyms: potassium:hydrogen antiporter activity
pyrimidine- and adenosine-specific:sodium symporter activity (GO:0015389)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in).
Synonyms: pyrimidine- and adenine-specific:sodium symporter activity
purine-specific nucleoside:sodium symporter activity (GO:0015390)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in).
nucleobase:monoatomic cation symporter activity (GO:0015391)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in).
Synonyms: nucleobase:cation symporter activity
obsolete uracil/uridine permease activity (GO:0015393)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: uracil/uridine permease activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
uridine:proton symporter activity (GO:0015394)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in).
Synonyms: nucleoside (uridine) permease activity; uridine:hydrogen ion symporter activity
nucleoside transmembrane transporter activity, down a concentration gradient (GO:0015395)
Namespace: molecular_function
Definition: Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient.
Synonyms: equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity; equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity; equilibrative nucleoside transporter activity
primary active transmembrane transporter activity (GO:0015399)
Namespace: molecular_function
Definition: Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy.
Synonyms: primary active transporter
obsolete low-affinity secondary active ammonium transmembrane transporter activity (GO:0015400)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
Synonyms: low affinity ammonium transmembrane transporter activity; low affinity secondary active ammonium transmembrane transporter activity
Comment: This term was obsoleted because it does not define a specific transport mechanism.
urea:sodium symporter activity (GO:0015401)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in).
Synonyms: urea active transmembrane transporter activity
obsolete ABC-type uptake permease activity (GO:0015406)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: ABC-type uptake permease activity
Comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
ABC-type monosaccharide transporter activity (GO:0015407)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported.
Synonyms: ATP-dependent monosaccharide transmembrane transporter activity; ATPase-coupled monosaccharide transmembrane transporter activity; monosaccharide ABC transporter; monosaccharide-importing ATPase activity; monosaccharide-transporting ATPase activity
ABC-type ferric iron transporter activity (GO:0015408)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in).
Synonyms: ABC-type Fe3+ transporter; ATPase-coupled ferric iron transmembrane transporter activity; Fe3+-transporting ATPase activity; ferric ABC transporter; ferric transporting ATPase activity; ferric-transporting ATPase activity
ABC-type manganese transporter activity (GO:0015410)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in).
Synonyms: ABC-type Mn(2+) transporter; ATP-dependent manganese transmembrane transporter activity; ATPase-coupled manganese transmembrane transporter activity; manganese ABC transporter; manganese transmembrane transporter activity, phosphorylative mechanism; manganese-transporting ATPase activity
ABC-type taurine transporter transporter activity (GO:0015411)
Namespace: molecular_function
Definition: Enables the transfer of taurine from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in).
Synonyms: ATP-dependent taurine transporter activity; ATPase-coupled taurine transporter activity; taurine ABC transporter; taurine-transporting ATPase activity
ABC-type molybdate transporter activity (GO:0015412)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in).
Synonyms: ATPase-coupled molybdate transmembrane transporter activity; molybdate ABC transporter; molybdate porter activity; molybdate transmembrane-transporting ATPase activity; molybdate transporting ATPase activity; molybdate-transporting ATPase activity
ABC-type nickel transporter activity (GO:0015413)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in).
Synonyms: ATP-dependent nickel transmembrane transporter activity; ATPase-coupled nickel transmembrane transporter activity; nickel ABC transporter; nickel ABC transporter activity; nickel porter activity; nickel transporting ATPase activity; nickel-transporting ATPase activity
ABC-type nitrate transporter activity (GO:0015414)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in).
Synonyms: ATPase-coupled nitrate transmembrane transporter activity; nitrate ABC transporter; nitrate transmembrane-transporting ATPase activity; nitrate transporting ATPase activity; nitrate-transporting ATPase activity
ATPase-coupled phosphate ion transmembrane transporter activity (GO:0015415)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in).
Synonyms: ABC phosphate transporter activity; ATP phosphohydrolase (phosphate-importing); phosphate ABC transporter; phosphate ion transmembrane-transporting ATPase activity; phosphate porter activity; phosphate transporting ATPase activity; phosphate-transporting ATPase activity
ABC-type phosphonate transporter activity (GO:0015416)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2).
Synonyms: alkylphosphonate ABC transporter activity; alkylphosphonate transmembrane transporter activity; alkylphosphonate transmembrane-transporting ATPase activity; ATP phosphohydrolase (phosphonate-transporting); ATPase-coupled alkylphosphonate transmembrane transporter activity; ATPase-coupled organic phosphonate transmembrane transporter activity; organic phosphonate transmembrane transporter activity; organic phosphonate transmembrane-transporting ATPase activity; phosphonate ABC transporter; phosphonate transporting ATPase activity; phosphonate-transporting ATPase activity