LiteFold/GO huggingface dataset:
histone H4K20me2 reader activity (GO:0140005)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H4 dimethylated at lysine 20.
Synonyms: H4K20me2 modified histone binding
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H3 reader activity (GO:0140006)
Namespace: molecular_function
Definition: A histone reader that specifically binds either to an unmodified histone H3 or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.
KICSTOR complex (GO:0140007)
Namespace: cellular_component
Definition: A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2.
histone H4 reader activity (GO:0140008)
Namespace: molecular_function
Definition: A histone reader that specifically binds either to an unmodified histone H4 or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.
L-aspartate import across plasma membrane (GO:0140009)
Namespace: biological_process
Definition: The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.
D-aspartate transmembrane transporter activity (GO:0140010)
Namespace: molecular_function
Definition: Enables the transfer of D-aspartate from one side of a membrane to the other.
histone H4K12ac reader activity (GO:0140011)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H4 acetylated at lysine 12.
Synonyms: H4K12ac modified histone binding
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H4K5ac reader activity (GO:0140012)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H4 acetylated at lysine 5.
Synonyms: H4K5ac modified histone binding
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
meiotic nuclear division (GO:0140013)
Namespace: biological_process
Definition: One of the two nuclear divisions that occur as part of the meiotic cell cycle.
Synonyms: meiosis
histone H3K14ac reader activity (GO:0140015)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 acetylated at lysine 14.
Synonyms: histone H3K14ac modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K18cr reader activity (GO:0140017)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 crotonylated at lysine 18.
Synonyms: H3K18cr modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
regulation of cytoplasmic translational fidelity (GO:0140018)
Namespace: biological_process
Definition: Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.
histone H3K9cr reader activity (GO:0140019)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 crotonylated at lysine 9.
Synonyms: H3K9cr modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
DNA methyltransferase complex (GO:0140020)
Namespace: cellular_component
Definition: A protein complex that possesses DNA methyltransferase activity.
cnida (GO:0140022)
Namespace: cellular_component
Definition: A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria.
Synonyms: cnidae (plural)
tRNA adenosine deamination to inosine (GO:0140023)
Namespace: biological_process
Definition: The removal of an amine group from an adenosine to produce inosine within a tRNA molecule.
Synonyms: A-to-I tRNA editing
plus-end-directed endosome transport along mitotic spindle midzone microtubule (GO:0140024)
Namespace: biological_process
Definition: The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination.
contractile vacuole dissociation from plasma membrane (GO:0140026)
Namespace: biological_process
Definition: The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network.
Synonyms: contractile vacuole detethering from plasma membrane
contractile vacuole localization (GO:0140027)
Namespace: biological_process
Definition: The directed movement of the contractile vacuole to a specific location.
Synonyms: establishment of contractile vacuole localization
pore formation during contractile vacuole discharge (GO:0140028)
Namespace: biological_process
Definition: The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes.
exocytic process (GO:0140029)
Namespace: biological_process
Definition: The cellular processes that contribute to exocytosis.
modification-dependent protein binding (GO:0140030)
Namespace: molecular_function
Definition: Binding to a protein upon post-translation modification of the target protein.
Synonyms: modified protein binding
Comment: This term should only be used when the binding is shown to require a post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
phosphorylation-dependent protein binding (GO:0140031)
Namespace: molecular_function
Definition: Binding to a protein upon phosphorylation of the target protein.
Comment: This term should only be used when the binding is shown to require phosphorylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of phosphorylation. It may be that the phosphorylation causes a conformational change that allows binding of the protein to another region; this type of phosphorylation-dependent protein binding is valid for annotation to this term.
glycosylation-dependent protein binding (GO:0140032)
Namespace: molecular_function
Definition: Binding to a protein upon glycosylation of the target protein.
Comment: This term should only be used when the binding is shown to require glycosylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of glycosylation. It may be that the glycosylation causes a conformational change that allows binding of the protein to another region; this type of glycosylation-dependent protein binding is valid for annotation to this term.
acetylation-dependent protein binding (GO:0140033)
Namespace: molecular_function
Definition: Binding to a protein upon acetylation of the target protein.
Comment: This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term.
methylation-dependent protein binding (GO:0140034)
Namespace: molecular_function
Definition: Binding to a protein upon methylation of the target protein.
Comment: This term should only be used when the binding is shown to require methylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of methylation. It may be that the methylation causes a conformational change that allows binding of the protein to another region; this type of methylation-dependent protein binding is valid for annotation to this term.
ubiquitin-like protein reader activity (GO:0140035)
Namespace: molecular_function
Definition: A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
Synonyms: ubiquitination-like modification-dependent protein binding; ubiquitination-like protein reader activity
Comment: This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
ubiquitin-modified protein reader activity (GO:0140036)
Namespace: molecular_function
Definition: A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
Synonyms: ubiquitin-dependent protein binding
Comment: This term should only be used when the binding is shown to require ubiquitination of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitination. It may be that the ubiquitination causes a conformational change that allows binding of the protein to another region; this type of ubiquitination-dependent protein binding is valid for annotation to this term.
SUMO-modified protein reader activity (GO:0140037)
Namespace: molecular_function
Definition: A molecular adaptor that recognizes and binds a target protein containing a SUMO modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
Synonyms: SUMO-dependent protein binding
Comment: This term should only be used when the binding is shown to require sumoylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of sumoylation. It may be that the sumoylation causes a conformational change that allows binding of the protein to another region; this type of sumoylation-dependent protein binding is valid for annotation to this term.
histone H3K27cr reader activity (GO:0140038)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 crotonylated at lysine 27.
Synonyms: histone H3K27cr modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
cell-cell adhesion in response to extracellular stimulus (GO:0140039)
Namespace: biological_process
Definition: The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.
mitochondrial polycistronic RNA processing (GO:0140040)
Namespace: biological_process
Definition: The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs.
lipid droplet localization to prospore membrane leading edge (GO:0140043)
Namespace: biological_process
Definition: Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge.
Synonyms: adiposome localization to ascospore-type prospore membrane leading edge; adiposome localization to forespore membrane leading edge; adiposome localization to FSM membrane leading edge; lipid body localization to ascospore-type prospore membrane leading edge; lipid body localization to forespore membrane leading edge; lipid body localization to FSM membrane leading edge; lipid particle localization to ascospore-type prospore membrane leading edge; lipid particle localization to forespore membrane leading edge; lipid particle localization to FSM membrane leading edge
histone H3K18ac reader activity (GO:0140044)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 acetylated at lysine 18.
Synonyms: histone H3K18ac modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H4K16ac reader activity (GO:0140046)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H4 acetylated at lysine 16.
Synonyms: H4K16ac modified histone binding
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
specialized extracellular matrix (GO:0140047)
Namespace: cellular_component
Definition: Species or cell-type specific extracellular matrices that are different from the two main types of extracellular matrices: the interstitial ECM and the basement membrane ECM in metazoa.
Synonyms: specialized ECM
manganese ion export across plasma membrane (GO:0140048)
Namespace: biological_process
Definition: The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region.
Synonyms: manganese ion export from cell
regulation of endocardial cushion to mesenchymal transition (GO:0140049)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition.
negative regulation of endocardial cushion to mesenchymal transition (GO:0140050)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition.
cellular response to oxidised low-density lipoprotein particle stimulus (GO:0140052)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.
Synonyms: cellular response to ox-LDL particle stimulus; cellular response to oxidised LDL particle stimulus; cellular response to oxidized LDL particle stimulus; cellular response to oxidized low-density lipoprotein particle stimulus; cellular response to oxLDL particle stimulus
mitochondrial gene expression (GO:0140053)
Namespace: biological_process
Definition: The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
histone H2A reader activity (GO:0140054)
Namespace: molecular_function
Definition: A histone reader that specifically binds either to an unmodified histone H2A or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.
Synonyms: histone H2A reader
histone H4K8ac reader activity (GO:0140055)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H4 acetylated at lysine 8.
Synonyms: H4K8ac modified histone binding
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
organelle localization by membrane tethering (GO:0140056)
Namespace: biological_process
Definition: The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.
vacuole-mitochondria membrane tethering (GO:0140057)
Namespace: biological_process
Definition: The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
neuron projection arborization (GO:0140058)
Namespace: biological_process
Definition: The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
Synonyms: branching morphogenesis of a neurite; branching morphogenesis of a neuron projection; neurite arborization; neurite branching; neuron projection branching
dendrite arborization (GO:0140059)
Namespace: biological_process
Definition: The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.
axon arborization (GO:0140060)
Namespace: biological_process
Definition: The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches.
obsolete 5-hydroxymethylcytosine dioxygenase activity (GO:0140061)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2.
Synonyms: 5hmC dioxygenase
Comment: This term was obsoleted because it is a substep of the reaction represented by 5-methylcytosine dioxygenase activity ; GO:0070579.
obsolete 5-formylcytosine dioxygenase activity (GO:0140062)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2.
Synonyms: 5fC dioxygenase
Comment: This term was obsoleted because it is a substep of the reaction represented by 5-methylcytosine dioxygenase activity ; GO:0070579.
unmodified histone reader activity (GO:0140063)
Namespace: molecular_function
Definition: A histone reader that specifically binds either to an unmodified histone.
Comment: Curator note: To annotate the specific histone recognized, use 'has input' extension.
peptide crotonyltransferase activity (GO:0140064)
Namespace: molecular_function
Definition: Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide.
Synonyms: protein crotonyltransferase activity
peptide butyryltransferase activity (GO:0140065)
Namespace: molecular_function
Definition: Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide.
Synonyms: protein butyryltransferase activity
peptidyl-lysine butyrylation (GO:0140067)
Namespace: biological_process
Definition: The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid.
histone crotonyltransferase activity (GO:0140068)
Namespace: molecular_function
Definition: Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.
histone butyryltransferase activity (GO:0140069)
Namespace: molecular_function
Definition: Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone.
hydrogen peroxide channel activity (GO:0140070)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of H2O2 through a transmembrane aqueous pore or channel.
Synonyms: hydrogen peroxide transmembrane transporter activity
histone H2B reader activity (GO:0140071)
Namespace: molecular_function
Definition: A histone reader that specifically binds either to an unmodified histone H2B or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.
Synonyms: histone H2B reader
histone H3K9ac reader activity (GO:0140072)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 acetylated at lysine 9.
Synonyms: H3K9ac modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
bioadhesive activity (GO:0140073)
Namespace: molecular_function
Definition: A structural molecule ativity that mediates an organism's attachment to an environmental substrate via stable, non-selective binding by a protein to an external surface. Examples includes proteins used by insects to anchor pupae to surfaces.
cardiac endothelial to mesenchymal transition (GO:0140074)
Namespace: biological_process
Definition: A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
Synonyms: EndMT; EndoMT
regulation of lipoprotein transport (GO:0140075)
Namespace: biological_process
Definition: Any process that controls lipoprotein transport.
negative regulation of lipoprotein transport (GO:0140076)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.