LiteFold/GO huggingface dataset:
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051896)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.
Synonyms: regulation of AKT signaling cascade; regulation of AKT signalling cascade; regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction; regulation of PI3K-PKB/Akt pathway; regulation of PI3K/Akt signal transduction; regulation of PI3K/PKB signal transduction; regulation of PKB signaling cascade; regulation of PKB signalling cascade; regulation of protein kinase B signaling; regulation of protein kinase B signaling cascade; regulation of protein kinase B signalling cascade
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.
Synonyms: activation of protein kinase B signaling cascade; positive regulation of AKT signaling cascade; positive regulation of AKT signalling cascade; positive regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction; positive regulation of PI3K-PKB/Akt pathway; positive regulation of PI3K/Akt signal transduction; positive regulation of PI3K/PKB signal transduction; positive regulation of PKB signaling cascade; positive regulation of PKB signalling cascade; positive regulation of protein kinase B signaling; positive regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signalling cascade; stimulation of protein kinase B signaling cascade; up regulation of protein kinase B signaling cascade; up-regulation of protein kinase B signaling cascade; upregulation of protein kinase B signaling cascade
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.
Synonyms: down regulation of protein kinase B signaling cascade; down-regulation of protein kinase B signaling cascade; downregulation of protein kinase B signaling cascade; inhibition of protein kinase B signaling cascade; negative regulation of AKT signaling cascade; negative regulation of AKT signalling cascade; negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction; negative regulation of PI3K-PKB/Akt pathway; negative regulation of PI3K/Akt signal transduction; negative regulation of PI3K/PKB signal transduction; negative regulation of PKB signaling cascade; negative regulation of PKB signalling cascade; negative regulation of protein kinase B signaling; negative regulation of protein kinase B signaling cascade; negative regulation of protein kinase B signalling cascade
membrane depolarization (GO:0051899)
Namespace: biological_process
Definition: The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
positive regulation of mitochondrial depolarization (GO:0051901)
Namespace: biological_process
Definition: Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
Synonyms: activation of mitochondrial depolarization; stimulation of mitochondrial depolarization; up regulation of mitochondrial depolarization; up-regulation of mitochondrial depolarization; upregulation of mitochondrial depolarization
negative regulation of mitochondrial depolarization (GO:0051902)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
Synonyms: down regulation of mitochondrial depolarization; down-regulation of mitochondrial depolarization; downregulation of mitochondrial depolarization; inhibition of mitochondrial depolarization
S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity (GO:0051903)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
Synonyms: ADH3 activity; chi-ADH activity; class III alcohol dehydrogenase activity; FDH activity; formic dehydrogenase activity; GD-FALDH activity; glutathione-dependent formaldehyde dehydrogenase activity; GS-FDH activity; NAD- and glutathione-dependent formaldehyde dehydrogenase activity; NAD-dependent formaldehyde dehydrogenase activity; NAD-linked formaldehyde dehydrogenase activity; S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity
pigment granule transport (GO:0051904)
Namespace: biological_process
Definition: The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: pigment granule translocation
establishment of pigment granule localization (GO:0051905)
Namespace: biological_process
Definition: The directed movement of a pigment granule to a specific location.
Synonyms: establishment of pigment granule localisation
maintenance of pigment granule location (GO:0051906)
Namespace: biological_process
Definition: Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere.
Synonyms: maintenance of pigment granule localization
S-(hydroxymethyl)glutathione synthase activity (GO:0051907)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione.
Synonyms: Gfa; glutathione-dependent formaldehyde-activating enzyme activity; S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming); S-(hydroxymethyl)glutathione formaldehyde-lyase activity
double-stranded DNA 5'-3' DNA exonuclease activity (GO:0051908)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule.
Synonyms: double-stranded DNA 5'-3' exodeoxyribonuclease activity; double-stranded DNA specific 5'-3' exodeoxyribonuclease activity
obsolete acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate (GO:0051909)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O.
Synonyms: 3-hydroxypropenoate dehydratase activity; acetylenecarboxylate hydratase activity; acetylenemonocarboxylate hydratase activity; alkynoate hydratase activity
Comment: This term was obsoleted because it represents the same activity as acetylenecarboxylate hydratase activity, producing 3-oxopropanoate ; GO:0050079.
Methanosarcina-phenazine hydrogenase activity (GO:0051911)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine.
Synonyms: coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity; hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity; methanophenazine hydrogenase activity; methylviologen-reducing hydrogenase activity
CoB--CoM heterodisulfide reductase activity (GO:0051912)
Namespace: molecular_function
Definition: Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine.
Synonyms: CoB-CoM heterodisulfide reductase activity; coenzyme B--coenzyme M heterodisulfide reductase activity; coenzyme B:coenzyme M:methanophenazine oxidoreductase activity; coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity; heterodisulfide reductase activity; soluble heterodisulfide reductase activity
regulation of synaptic plasticity by chemical substance (GO:0051913)
Namespace: biological_process
Definition: The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require.
Synonyms: regulation of synaptic plasticity by drug
positive regulation of synaptic plasticity by chemical substance (GO:0051914)
Namespace: biological_process
Definition: The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require.
Synonyms: activation of synaptic plasticity by chemical substance; positive regulation of synaptic plasticity by drug; stimulation of synaptic plasticity by chemical substance; up regulation of synaptic plasticity by chemical substance; up-regulation of synaptic plasticity by chemical substance; upregulation of synaptic plasticity by chemical substance
induction of synaptic plasticity by chemical substance (GO:0051915)
Namespace: biological_process
Definition: The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require.
Synonyms: activation of synaptic plasticity by chemical substance; activation of synaptic plasticity by drug; induction of synaptic plasticity by drug
granulocyte colony-stimulating factor binding (GO:0051916)
Namespace: molecular_function
Definition: Binding to granulocyte colony-stimulating factor, G-CSF.
Synonyms: G-CSF binding; granulocyte colony stimulating factor binding
negative regulation of fibrinolysis (GO:0051918)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
Synonyms: down regulation of fibrinolysis; down-regulation of fibrinolysis; downregulation of fibrinolysis; inhibition of fibrinolysis
positive regulation of fibrinolysis (GO:0051919)
Namespace: biological_process
Definition: Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
Synonyms: activation of fibrinolysis; stimulation of fibrinolysis; up regulation of fibrinolysis; up-regulation of fibrinolysis; upregulation of fibrinolysis
peroxiredoxin activity (GO:0051920)
Namespace: molecular_function
Definition: Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
Synonyms: PRDX activity; Prx activity
Comment: Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself).
adenosylcobyric acid synthase (glutamine-hydrolyzing) activity (GO:0051921)
Namespace: molecular_function
Definition: Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H+ + 4 phosphate.
Synonyms: 5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity; adenosylcobyric acid synthase (glutamine-hydrolysing) activity; adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming); Ado-cobyric acid synthase [glutamine hydrolyzing] activity; CobQ activity; cobyric acid synthase activity
cholesterol sulfotransferase activity (GO:0051922)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+.
sulfation (GO:0051923)
Namespace: biological_process
Definition: The addition of a sulfate group to a molecule.
Synonyms: phase II metabolism; sulfonation; sulfur addition; sulphation; sulphur addition
regulation of calcium ion transport (GO:0051924)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: regulation of calcium transport
obsolete regulation of calcium ion transport via voltage-gated calcium channel activity (GO:0051925)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel.
Synonyms: regulation of calcium ion transport via voltage-gated calcium channel activity; regulation of calcium transport via voltage-gated calcium channel
Comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
negative regulation of calcium ion transport (GO:0051926)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of calcium ion transport; down-regulation of calcium ion transport; downregulation of calcium ion transport; inhibition of calcium ion transport; negative regulation of calcium transport
obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity (GO:0051927)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel.
Synonyms: down regulation of calcium ion transport via voltage gated calcium channel; down-regulation of calcium ion transport via voltage gated calcium channel; downregulation of calcium ion transport via voltage gated calcium channel; inhibition of calcium ion transport via voltage gated calcium channel; negative regulation of calcium ion transport via voltage-gated calcium channel activity; negative regulation of calcium transport via voltage gated calcium channel
Comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
positive regulation of calcium ion transport (GO:0051928)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of calcium ion transport; positive regulation of calcium transport; stimulation of calcium ion transport; up regulation of calcium ion transport; up-regulation of calcium ion transport; upregulation of calcium ion transport
obsolete positive regulation of calcium ion transport via voltage-gated calcium channel activity (GO:0051929)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels.
Synonyms: activation of calcium ion transport via voltage gated calcium channel; positive regulation of calcium ion transport via voltage-gated calcium channel activity; positive regulation of calcium transport via voltage gated calcium channel; stimulation of calcium ion transport via voltage gated calcium channel; up regulation of calcium ion transport via voltage gated calcium channel; up-regulation of calcium ion transport via voltage gated calcium channel; upregulation of calcium ion transport via voltage gated calcium channel
Comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round.
regulation of sensory perception of pain (GO:0051930)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
regulation of sensory perception (GO:0051931)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.
synaptic transmission, GABAergic (GO:0051932)
Namespace: biological_process
Definition: The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms: GABAergic synaptic transmission; synaptic transmission, GABA mediated; synaptic transmission, gamma-aminobutyric acid mediated; synaptic transmission, gamma-aminobutyric acid-ergic
amino acid neurotransmitter reuptake (GO:0051933)
Namespace: biological_process
Definition: The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
Synonyms: amino acid neurotransmitter import into glial cell; amino acid neurotransmitter import into neuron; amino acid neurotransmitter recycling; amino acid uptake during transmission of nerve impulse
obsolete catecholamine uptake involved in synaptic transmission (GO:0051934)
Namespace: biological_process
Definition: OBSOLETE. The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
Synonyms: catecholamine neurotransmitter import into glial cell; catecholamine neurotransmitter import into neuron; catecholamine neurotransmitter recycling; catecholamine neurotransmitter reuptake; catecholamine reuptake during transmission of nerve impulse; catecholamine uptake during transmission of nerve impulse
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
glutamate reuptake (GO:0051935)
Namespace: biological_process
Definition: The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
Synonyms: glutamate import into glial cell; glutamate import into neuron; glutamate recycling; glutamate uptake during transmission of nerve impulse; L-glutamate reuptake; L-glutamate uptake during transmission of nerve impulse; L-glutamate uptake involved in synaptic transmission
catecholamine transport (GO:0051937)
Namespace: biological_process
Definition: The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
L-glutamate import (GO:0051938)
Namespace: biological_process
Definition: The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle.
Synonyms: L-glutamate uptake
gamma-aminobutyric acid import (GO:0051939)
Namespace: biological_process
Definition: The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle.
Synonyms: 4-aminobutyrate import; GABA import; gamma-aminobutyrate import; gamma-aminobutyric acid uptake
obsolete regulation of amino acid uptake involved in synaptic transmission (GO:0051941)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell.
Synonyms: regulation of amino acid neurotransmitter reuptake; regulation of amino acid neurotransmitter uptake; regulation of amino acid uptake during transmission of nerve impulse
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete negative regulation of amino acid uptake involved in synaptic transmission (GO:0051942)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell.
Synonyms: down regulation of amino acid uptake during transmission of nerve impulse; down-regulation of amino acid uptake during transmission of nerve impulse; downregulation of amino acid uptake during transmission of nerve impulse; inhibition of amino acid uptake during transmission of nerve impulse; negative regulation of amino acid neurotransmitter reuptake; negative regulation of amino acid neurotransmitter uptake; negative regulation of amino acid uptake during transmission of nerve impulse
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete positive regulation of amino acid uptake involved in synaptic transmission (GO:0051943)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell.
Synonyms: activation of amino acid uptake during transmission of nerve impulse; positive regulation of amino acid neurotransmitter reuptake; positive regulation of amino acid neurotransmitter uptake; stimulation of amino acid uptake during transmission of nerve impulse; up regulation of amino acid uptake during transmission of nerve impulse; up-regulation of amino acid uptake during transmission of nerve impulse; upregulation of amino acid uptake during transmission of nerve impulse
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
positive regulation of catecholamine uptake involved in synaptic transmission (GO:0051944)
Namespace: biological_process
Definition: Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell.
Synonyms: activation of catecholamine uptake during transmission of nerve impulse; positive regulation of catecholamine neurotransmitter reuptake; positive regulation of catecholamine neurotransmitter uptake; positive regulation of catecholamine uptake during transmission of nerve impulse; stimulation of catecholamine uptake during transmission of nerve impulse; up regulation of catecholamine uptake during transmission of nerve impulse; up-regulation of catecholamine uptake during transmission of nerve impulse; upregulation of catecholamine uptake during transmission of nerve impulse
obsolete negative regulation of catecholamine uptake involved in synaptic transmission (GO:0051945)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell.
Synonyms: down regulation of catecholamine uptake during transmission of nerve impulse; down-regulation of catecholamine uptake during transmission of nerve impulse; downregulation of catecholamine uptake during transmission of nerve impulse; inhibition of catecholamine uptake during transmission of nerve impulse; negative regulation of catecholamine neurotransmitter reuptake; negative regulation of catecholamine neurotransmitter uptake; negative regulation of catecholamine uptake during transmission of nerve impulse
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.