LiteFold/GO huggingface dataset:
intramolecular oxidoreductase activity, interconverting aldoses and ketoses (GO:0016861)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.
Synonyms: intramolecular isomerase activity, interconverting aldoses and ketoses
intramolecular oxidoreductase activity, interconverting keto- and enol-groups (GO:0016862)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears.
Synonyms: intramolecular isomerase activity, interconverting keto- and enol-groups
intramolecular oxidoreductase activity, transposing C=C bonds (GO:0016863)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears.
Synonyms: intramolecular isomerase activity, transposing C=C bonds
intramolecular oxidoreductase activity, transposing S-S bonds (GO:0016864)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears.
Synonyms: intramolecular isomerase activity, transposing S-S bonds
obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases (GO:0016865)
Namespace: molecular_function
Definition: OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized.
Synonyms: intramolecular isomerase activity, other intramolecular oxidoreductases; intramolecular oxidoreductase activity, other intramolecular oxidoreductases
Comment: This term was made obsolete because it was an unnecessary grouping term.
intramolecular transferase activity (GO:0016866)
Namespace: molecular_function
Definition: Catalysis of the transfer of a functional group from one position to another within a single molecule.
Synonyms: intramolecular transferase activity, transferring other groups; mutase activity
intramolecular acyltransferase activity (GO:0016867)
Namespace: molecular_function
Definition: Catalysis of the transfer of an acyl group from one position to another within a single molecule.
Synonyms: intramolecular transferase activity, transferring acyl groups
intramolecular phosphotransferase activity (GO:0016868)
Namespace: molecular_function
Definition: Catalysis of the transfer of a phosphate group from one position to another within a single molecule.
Synonyms: intramolecular transferase activity, phosphotransferases; phosphomutase activity; phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers
intramolecular aminotransferase activity (GO:0016869)
Namespace: molecular_function
Definition: Catalysis of the transfer of an amino group from one position to another within a single molecule.
Synonyms: intramolecular transferase activity, transferring amino groups
obsolete intramolecular transferase activity, transferring other groups (GO:0016870)
Namespace: molecular_function
Definition: OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized.
Synonyms: intramolecular transferase activity, transferring other groups
Comment: This term was made obsolete because it was an unnecessary grouping term.
cycloartenol synthase activity (GO:0016871)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol.
Synonyms: (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming); 2,3-epoxysqualene cycloartenol-cyclase activity; 2,3-epoxysqualene--cycloartenol cyclase activity; 2,3-oxidosqualene-cycloartenol cyclase activity; oxidosqualene:cycloartenol cyclase activity; squalene-2,3-epoxide-cycloartenol cyclase activity
intramolecular lyase activity (GO:0016872)
Namespace: molecular_function
Definition: The catalysis of certain rearrangements of a molecule to break or form a ring.
obsolete other isomerase activity (GO:0016873)
Namespace: molecular_function
Definition: OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized.
Synonyms: other isomerase activity
Comment: This term was made obsolete because it was an unnecessary grouping term.
ligase activity (GO:0016874)
Namespace: molecular_function
Definition: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
Synonyms: synthetase activity
ligase activity, forming carbon-oxygen bonds (GO:0016875)
Namespace: molecular_function
Definition: Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ligase activity, forming carbon-sulfur bonds (GO:0016877)
Namespace: molecular_function
Definition: Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
Synonyms: ligase activity, forming carbon-sulphur bonds
acid-thiol ligase activity (GO:0016878)
Namespace: molecular_function
Definition: Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ligase activity, forming carbon-nitrogen bonds (GO:0016879)
Namespace: molecular_function
Definition: Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
Synonyms: other carbon-nitrogen ligase activity
acid-ammonia (or amide) ligase activity (GO:0016880)
Namespace: molecular_function
Definition: Catalysis of the ligation of an acid to ammonia (NH4+) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
Synonyms: amide synthase activity
cyclo-ligase activity (GO:0016882)
Namespace: molecular_function
Definition: Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
obsolete other carbon-nitrogen ligase activity (GO:0016883)
Namespace: molecular_function
Definition: OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized.
Synonyms: other carbon-nitrogen ligase activity
Comment: This term was made obsolete because it was an unnecessary grouping term.
carbon-nitrogen ligase activity, with glutamine as amido-N-donor (GO:0016884)
Namespace: molecular_function
Definition: Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen.
ligase activity, forming carbon-carbon bonds (GO:0016885)
Namespace: molecular_function
Definition: Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ligase activity, forming phosphoric ester bonds (GO:0016886)
Namespace: molecular_function
Definition: Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ATP hydrolysis activity (GO:0016887)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
Synonyms: adenosine 5'-triphosphatase activity; adenosine triphosphatase activity; adenosinetriphosphatase activity; ATP hydrolase activity; ATP monophosphatase activity; ATP phosphohydrolase activity
Comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function.
DNA endonuclease activity, producing 5'-phosphomonoesters (GO:0016888)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
Synonyms: endodeoxyribonuclease activity, producing 5' phosphomonoesters; endodeoxyribonuclease activity, producing 5'-phosphomonoesters
DNA endonuclease activity, producing 3'-phosphomonoesters (GO:0016889)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
Synonyms: endodeoxyribonuclease activity, producing 3'-phosphomonoesters; endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters
obsolete site-specific endodeoxyribonuclease activity, specific for altered base (GO:0016890)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks.
Comment: The reason for obsoletion is that this term was an unnecessary grouping term.
RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism (GO:0016891)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
Synonyms: endoribonuclease activity, producing 5'-phosphomonoesters
RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism (GO:0016892)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
Synonyms: endoribonuclease activity, producing 3'-phosphomonoesters; endoribonuclease activity, producing other than 5'-phosphomonoesters
obsolete endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (GO:0016893)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
Synonyms: 5'-endonuclease activity; endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
Comment: This term was obsoleted because it is an unnecessary grouping term.
obsolete endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters (GO:0016894)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
Synonyms: 3'-endonuclease activity; endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
Comment: This term was obsoleted because it is an unnecessary grouping term.
DNA exonuclease activity, producing 5'-phosphomonoesters (GO:0016895)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.
Synonyms: exodeoxyribonuclease activity, producing 5' phosphomonoesters; exonuclease VIII activity
RNA exonuclease activity, producing 5'-phosphomonoesters (GO:0016896)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.
Synonyms: exoribonuclease activity, producing 5' phosphomonoesters; exoribonuclease activity, producing 5'-phosphomonoesters
obsolete RNA exonuclease activity, producing 3'-phosphomonoesters (GO:0016897)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters.
Synonyms: exoribonuclease activity, producing 3'-phosphomonoesters
Comment: This term was obsoleted because there is no evidence that this specific activity exists.
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor (GO:0016898)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule.
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor (GO:0016899)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule.
obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor (GO:0016900)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule.
Synonyms: oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor
Comment: This term was obsoleted because there is no evidence that this specific activity exists.
oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor (GO:0016901)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors (GO:0016902)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound.
Synonyms: oxidoreductase activity, acting on the CH-OH group of donors, other acceptors
Comment: This term was made obsolete because it was an unnecessary grouping term.
oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
Synonyms: oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors
myosin heavy chain kinase activity (GO:0016905)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate.
Synonyms: ATP:myosin heavy-chain O-phosphotransferase activity; ATP:myosin-heavy-chain O-phosphotransferase activity; calmodulin-dependent myosin heavy chain kinase activity; MHCK; MIHC kinase activity; myosin heavy chain kinase A activity; myosin heavy-chain kinase activity; myosin I heavy chain kinase activity; myosin I heavy-chain kinase activity; myosin II heavy chain kinase activity; myosin II heavy-chain kinase activity; myosin-heavy-chain kinase activity; STK6
sterol 3-beta-glucosyltransferase activity (GO:0016906)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol.
Synonyms: sterol 3beta-glucosyltransferase activity; sterol glucosyltransferase activity; sterol-beta-D-glucosyltransferase activity; sterol:UDPG glucosyltransferase activity; UDP-glucose-sterol beta-glucosyltransferase activity; UDP-glucose-sterol glucosyltransferase activity; UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity; UDP-glucose:sterol glucosyltransferase activity; UDPG-SGTase activity; UDPG:sterol glucosyltransferase activity; UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity; uridine diphosphoglucose-poriferasterol glucosyltransferase activity; uridine diphosphoglucose-sterol glucosyltransferase activity
G protein-coupled acetylcholine receptor activity (GO:0016907)
Namespace: molecular_function
Definition: Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: acetylcholine receptor activity, G-protein coupled; G protein coupled acetylcholine receptor activity; G-protein coupled acetylcholine receptor activity; metabotropic acetylcholine receptor activity; muscarinic acetylcholine receptor activity
obsolete SAP kinase 3 activity (GO:0016910)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: SAP kinase 3 activity; SAPK3
Comment: This term was made obsolete because it describes a gene product.
obsolete SAP kinase 4 activity (GO:0016911)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: SAP kinase 4 activity; SAPK4
Comment: This term was made obsolete because it describes a gene product.
obsolete SAP kinase 5 activity (GO:0016912)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: SAP kinase 5 activity; SAPK5
Comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product.
follicle-stimulating hormone activity (GO:0016913)
Namespace: molecular_function
Definition: The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.
Synonyms: follicle stimulating hormone activity; follitropin activity; FSH activity
follicle-stimulating hormone complex (GO:0016914)
Namespace: cellular_component
Definition: A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity.
Synonyms: follicle stimulating hormone complex; FSH complex
obsolete activin (GO:0016915)
Namespace: molecular_function
Definition: OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone.
Synonyms: activin
Comment: This term was made obsolete because it represents a gene product.
obsolete inhibin (GO:0016916)
Namespace: molecular_function
Definition: OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone.
Synonyms: inhibin
Comment: This term was made obsolete because it represents a gene product.
GABA receptor activity (GO:0016917)
Namespace: molecular_function
Definition: Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.
Synonyms: 4-aminobutanoate receptor activity; 4-aminobutyrate receptor activity; GABA binding; gamma-aminobutyrate binding; gamma-aminobutyric acid binding; gamma-aminobutyric acid receptor activity
Comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'.
retinal binding (GO:0016918)
Namespace: molecular_function
Definition: Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.
Synonyms: blue-sensitive opsin; green-sensitive opsin; long-wave-sensitive opsin; opsin; red-sensitive opsin; retinaldehyde binding; short-wave-sensitive opsin; UV-sensitive opsin; violet-sensitive opsin; vitamin A binding
obsolete nardilysin activity (GO:0016919)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys.
Synonyms: N-arginine dibasic convertase activity; nardilysin activity; NRD convertase activity; NRD-convertase activity
Comment: This term was made obsolete because it represents a gene product.
pyroglutamyl-peptidase activity (GO:0016920)
Namespace: molecular_function
Definition: Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein.
nuclear receptor binding (GO:0016922)
Namespace: molecular_function
Definition: Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.
Synonyms: ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor interactor activity; nuclear hormone receptor binding; steroid hormone receptor binding
obsolete ligand-dependent thyroid hormone receptor interactor activity (GO:0016923)
Namespace: molecular_function
Definition: OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor.
Synonyms: ligand-dependent thyroid hormone receptor interactor activity; TRIP4
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
protein desumoylation (GO:0016926)
Namespace: biological_process
Definition: The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.
Synonyms: desumoylation; protein desumolation
deSUMOylase activity (GO:0016929)
Namespace: molecular_function
Definition: An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated.
Synonyms: SUMO-specific isopeptidase activity; SUMO-specific protease activity; SUSP; ULP
extracellularly glycine-gated ion channel activity (GO:0016933)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms: extracellular-glycine-gated ion channel activity; glycine receptor
extracellularly glycine-gated chloride channel activity (GO:0016934)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms: extracellular-glycine-gated chloride channel activity; glycine receptor; glycine-inhibited chloride channel activity
glycine-gated chloride channel complex (GO:0016935)
Namespace: cellular_component
Definition: A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.
galactoside binding (GO:0016936)
Namespace: molecular_function
Definition: Binding to a glycoside in which the sugar group is galactose.