LiteFold/GO huggingface dataset:
obsolete vitamin D4 metabolic process (GO:0070641)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol.
Synonyms: vitamin D4 metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete vitamin D5 metabolic process (GO:0070642)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol.
Synonyms: vitamin D5 metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete vitamin D 25-hydroxylase activity (GO:0070643)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydroxylation of C-25 of any form of vitamin D.
Synonyms: calciferol 25-hydroxylase activity; cholecalciferol 25-hydroxylase activity; ergocalciferol 25-hydroxylase activity; vitamin D2 25-hydroxylase activity
Comment: This term was obsoleted because it was an unnecessary grouping term.
vitamin D response element binding (GO:0070644)
Namespace: molecular_function
Definition: Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.
Synonyms: VDRE binding
Ubisch body (GO:0070645)
Namespace: cellular_component
Definition: A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development.
Synonyms: orbicule
protein modification by small protein removal (GO:0070646)
Namespace: biological_process
Definition: A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein.
protein modification by small protein conjugation or removal (GO:0070647)
Namespace: biological_process
Definition: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
formin-nucleated actin cable (GO:0070648)
Namespace: cellular_component
Definition: An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth.
formin-nucleated actin cable assembly (GO:0070649)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
Synonyms: formin-nucleated actin cable formation
actin filament bundle distribution (GO:0070650)
Namespace: biological_process
Definition: Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell.
nonfunctional rRNA decay (GO:0070651)
Namespace: biological_process
Definition: An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.
Synonyms: NRD
HAUS complex (GO:0070652)
Namespace: cellular_component
Definition: A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.
Synonyms: HAUS augmin complex
high-density lipoprotein particle receptor binding (GO:0070653)
Namespace: molecular_function
Definition: Binding to a high-density lipoprotein receptor.
Synonyms: HDL receptor binding; high-density lipoprotein receptor binding
sensory epithelium regeneration (GO:0070654)
Namespace: biological_process
Definition: The regrowth of a sensory epithelium following its loss or destruction.
mechanosensory epithelium regeneration (GO:0070655)
Namespace: biological_process
Definition: The regrowth of lost or destroyed mechanosensory epithelia.
mechanoreceptor differentiation involved in mechanosensory epithelium regeneration (GO:0070656)
Namespace: biological_process
Definition: Differentiation of new mechanoreceptors to replace those lost or destroyed by injury.
neuromast regeneration (GO:0070657)
Namespace: biological_process
Definition: The regrowth of a neuromast following its loss or destruction.
neuromast hair cell differentiation involved in neuromast regeneration (GO:0070658)
Namespace: biological_process
Definition: Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury.
inner ear sensory epithelium regeneration (GO:0070659)
Namespace: biological_process
Definition: The regrowth of lost or destroyed inner ear sensory epithelia.
inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration (GO:0070660)
Namespace: biological_process
Definition: Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury.
leukocyte proliferation (GO:0070661)
Namespace: biological_process
Definition: The expansion of a leukocyte population by cell division.
mast cell proliferation (GO:0070662)
Namespace: biological_process
Definition: The expansion of a mast cell population by cell division.
regulation of leukocyte proliferation (GO:0070663)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of leukocyte proliferation.
negative regulation of leukocyte proliferation (GO:0070664)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.
Synonyms: down regulation of leukocyte proliferation; down-regulation of leukocyte proliferation; downregulation of leukocyte proliferation; inhibition of leukocyte proliferation
positive regulation of leukocyte proliferation (GO:0070665)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.
Synonyms: activation of leukocyte proliferation; stimulation of leukocyte proliferation; up regulation of leukocyte proliferation; up-regulation of leukocyte proliferation; upregulation of leukocyte proliferation
regulation of mast cell proliferation (GO:0070666)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mast cell proliferation.
negative regulation of mast cell proliferation (GO:0070667)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of mast cell proliferation.
Synonyms: down regulation of mast cell proliferation; down-regulation of mast cell proliferation; downregulation of mast cell proliferation; inhibition of mast cell proliferation
positive regulation of mast cell proliferation (GO:0070668)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of mast cell proliferation.
Synonyms: activation of mast cell proliferation; stimulation of mast cell proliferation; up regulation of mast cell proliferation; up-regulation of mast cell proliferation; upregulation of mast cell proliferation
response to interleukin-2 (GO:0070669)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus.
Synonyms: response to IL-2
response to interleukin-4 (GO:0070670)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
Synonyms: response to IL-4
response to interleukin-12 (GO:0070671)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.
Synonyms: response to IL-12
response to interleukin-15 (GO:0070672)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus.
Synonyms: response to IL-15
response to interleukin-18 (GO:0070673)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus.
Synonyms: response to IL-18
hypoxanthine dehydrogenase activity (GO:0070674)
Namespace: molecular_function
Definition: Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+.
Synonyms: hypoxanthine oxidoreductase activity; hypoxanthine-NAD oxidoreductase activity; hypoxanthine/NAD(+) oxidoreductase activity; hypoxanthine/NAD+ oxidoreductase activity; hypoxanthine:NAD+ oxidoreductase activity; NAD-hypoxanthine dehydrogenase activity
hypoxanthine oxidase activity (GO:0070675)
Namespace: molecular_function
Definition: Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2.
Synonyms: hypoxanthine-xanthine oxidase activity; hypoxanthine:O2 oxidoreductase activity; hypoxanthine:oxygen oxidoreductase activity; schardinger enzyme; Schardinger enzyme activity; xanthine oxidoreductase activity
intralumenal vesicle formation (GO:0070676)
Namespace: biological_process
Definition: The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome.
Synonyms: endosome membrane budding
rRNA (cytosine-2'-O-ribose)-methyltransferase activity (GO:0070677)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine.
Synonyms: rRNA (cytosine-2'-O-)-methyltransferase activity
preprotein binding (GO:0070678)
Namespace: molecular_function
Definition: Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.
Synonyms: unprocessed protein binding
inositol 1,4,5 trisphosphate binding (GO:0070679)
Namespace: molecular_function
Definition: Binding to inositol 1,4,5 trisphosphate.
Synonyms: InsP3 binding; IP3 binding
glutaminyl-tRNAGln biosynthesis via transamidation (GO:0070681)
Namespace: biological_process
Definition: A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase.
proteasome regulatory particle assembly (GO:0070682)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex.
Synonyms: proteasome regulatory complex assembly
macropinocytic cup (GO:0070685)
Namespace: cellular_component
Definition: A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin.
Synonyms: crown
macropinocytic cup membrane (GO:0070686)
Namespace: cellular_component
Definition: The portion of the plasma membrane surrounding a macropinocytic cup.
Synonyms: crown membrane
macropinocytic cup cytoskeleton (GO:0070687)
Namespace: cellular_component
Definition: The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup.
Synonyms: crown cytoskeleton
obsolete MLL5-L complex (GO:0070688)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively.
Comment: This term was made obsolete because there is no evidence for the existence of this complex.
obsolete L-threonine catabolic process to propionate (GO:0070689)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate.
Synonyms: L-threonine breakdown to propionate; L-threonine catabolism to propionate; L-threonine degradation to propionate; threonine catabolic process to propionate
Comment: This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.
obsolete L-threonine catabolic process to acetyl-CoA (GO:0070690)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA.
Synonyms: L-threonine breakdown to acetyl-CoA; L-threonine catabolism to acetyl-CoA; L-threonine degradation to acetyl-CoA; threonine catabolic process to acetyl-CoA
Comment: This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.
P-TEFb complex (GO:0070691)
Namespace: cellular_component
Definition: A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T.
Synonyms: Bur1/Bur2 complex; cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex; cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex; dimeric positive transcription elongation factor complex b; Sgv1/Bur2 complex
CTDK-1 complex (GO:0070692)
Namespace: cellular_component
Definition: A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638).
Synonyms: C-terminal domain kinase I complex; CTDK-I complex; Ctk complex; trimeric positive transcription elongation factor complex b
P-TEFb-cap methyltransferase complex (GO:0070693)
Namespace: cellular_component
Definition: A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase.
Synonyms: Cdk9-Pcm1 complex; P-TEFb-Pcm1 complex
5-hydroxymethyl-dUMP N-hydrolase activity (GO:0070694)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil.
Synonyms: deoxynucleoside 5'-monophosphate N-glycosidase activity
FHF complex (GO:0070695)
Namespace: cellular_component
Definition: A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).
Comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
transmembrane receptor protein serine/threonine kinase binding (GO:0070696)
Namespace: molecular_function
Definition: Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity.
activin receptor binding (GO:0070697)
Namespace: molecular_function
Definition: Binding to an activin receptor.
type I activin receptor binding (GO:0070698)
Namespace: molecular_function
Definition: Binding to a type I activin receptor.
type II activin receptor binding (GO:0070699)
Namespace: molecular_function
Definition: Binding to a type II activin receptor.
mucus layer (GO:0070701)
Namespace: cellular_component
Definition: An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes.
Synonyms: extracellular proteinaceous gel; mucous; mucous layer; mucus
inner mucus layer (GO:0070702)
Namespace: cellular_component
Definition: The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria.
outer mucus layer (GO:0070703)
Namespace: cellular_component
Definition: The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria.
sterol desaturase activity (GO:0070704)
Namespace: molecular_function
Definition: Catalysis of the introduction of a double bond into a sterol molecule.
RNA nucleotide insertion (GO:0070705)
Namespace: biological_process
Definition: The modification of an RNA molecule by insertion of one or more nucleotides.
RNA dinucleotide insertion (GO:0070707)
Namespace: biological_process
Definition: The modification of an RNA molecule by insertion of a dinucleotide.
RNA cytidine insertion (GO:0070708)
Namespace: biological_process
Definition: The modification of an RNA molecule by insertion of a cytidine nucleotide.
Synonyms: RNA C insertion
RNA guanosine insertion (GO:0070709)
Namespace: biological_process
Definition: The modification of an RNA molecule by insertion of a guanosine nucleotide.
Synonyms: RNA G insertion
RNA adenosine-uridine insertion (GO:0070711)
Namespace: biological_process
Definition: The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide.
Synonyms: RNA AU insertion
RNA guanosine-cytidine insertion (GO:0070713)
Namespace: biological_process
Definition: The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide.
Synonyms: RNA GC insertion
RNA guanosine-uridine insertion (GO:0070714)
Namespace: biological_process
Definition: The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide.
Synonyms: RNA GU insertion
sodium-dependent organic cation transport (GO:0070715)
Namespace: biological_process
Definition: The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication (GO:0070716)
Namespace: biological_process
Definition: A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication.
Synonyms: mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication
poly-purine tract binding (GO:0070717)
Namespace: molecular_function
Definition: Binding to a stretch of purines (adenine or guanine) in an RNA molecule.
alphaPDGFR-SHP-2 complex (GO:0070718)
Namespace: cellular_component
Definition: A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
Synonyms: PDGFRA-SHP-2 complex, PDGF stimulated
alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex (GO:0070719)
Namespace: cellular_component
Definition: A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
Synonyms: PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated
Grb2-SHP-2 complex (GO:0070720)
Namespace: cellular_component
Definition: A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.
Synonyms: GRB2-SHP-2 complex, PDGF stimulated
ISGF3 complex (GO:0070721)
Namespace: cellular_component
Definition: A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein.
Synonyms: interferon-stimulated gene factor 3 transcription complex
Tle3-Aes complex (GO:0070722)
Namespace: cellular_component
Definition: A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.
Synonyms: Grg3b-Grg5 complex
response to cholesterol (GO:0070723)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
BMP receptor complex (GO:0070724)
Namespace: cellular_component
Definition: A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.
Synonyms: bone morphogenetic protein receptor complex
Yb body (GO:0070725)
Namespace: cellular_component
Definition: A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell.
L-leucine binding (GO:0070728)
Namespace: molecular_function
Definition: Binding to L-leucine, 2-amino-4-methylpentanoic acid.
Synonyms: Leu binding; leucine binding
cyclic nucleotide transport (GO:0070729)
Namespace: biological_process
Definition: The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell.
cGMP transport (GO:0070731)
Namespace: biological_process
Definition: The directed movement of cyclic GMP (cGMP), into, out of or within a cell.
Synonyms: cyclic GMP transport
spindle envelope (GO:0070732)
Namespace: cellular_component
Definition: An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase.
AMPylase activity (GO:0070733)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins.
Synonyms: adenosine monophosphate-protein transferase activity; AMPylator; protein adenylyltransferase activity