LiteFold/GO huggingface dataset:
2,3-dihydroxybenzoate 3,4-dioxygenase activity (GO:0045133)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H+.
Synonyms: 2,3-dihydroxybenzoate 1,2-dioxygenase activity; 2,3-dihydroxybenzoate oxygenase activity; 2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing); 2,3-dihydroxybenzoic oxygenase activity; o-pyrocatechuate oxygenase activity
UDP phosphatase activity (GO:0045134)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP + H2O = UMP + phosphate.
Synonyms: UDP phosphohydrolase activity; UDPase activity; uridine 5'-diphosphatase activity; uridine diphosphatase activity; uridine-diphosphatase activity
poly(beta-D-mannuronate) lyase activity (GO:0045135)
Namespace: molecular_function
Definition: Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends.
Synonyms: alginase activity; alginase I; alginate lyase activity; alginate lyase I activity; poly(beta-D-1,4-mannuronide) lyase activity; poly(mana) alginate lyase activity
development of primary sexual characteristics (GO:0045137)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.
nematode male tail tip morphogenesis (GO:0045138)
Namespace: biological_process
Definition: The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
Synonyms: male tail morphogenesis; male tail tip morphogenesis; tail tip morphogenesis
obsolete copper sensitivity/resistance (GO:0045139)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: copper sensitivity/resistance
Comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
inositol phosphoceramide synthase activity (GO:0045140)
Namespace: molecular_function
Definition: Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol.
Synonyms: IPC synthase activity
meiotic telomere clustering (GO:0045141)
Namespace: biological_process
Definition: The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis.
Synonyms: bouquet biosynthesis; bouquet formation
triplex DNA binding (GO:0045142)
Namespace: molecular_function
Definition: Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.
homologous chromosome segregation (GO:0045143)
Namespace: biological_process
Definition: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.
Synonyms: meiosis I, chromosome segregation
obsolete initiation of acetate catabolic process by acetate (GO:0045146)
Namespace: biological_process
Definition: OBSOLETE. The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.
Synonyms: initiation of acetate breakdown by acetate; initiation of acetate degradation by acetate
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete regulation of initiation of acetate catabolic process by acetate (GO:0045147)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.
Synonyms: regulation of initiation of acetate breakdown by acetate; regulation of initiation of acetate degradation by acetate
Comment: The reason for obsoletion is that this term represents a molecular function.
acetoin metabolic process (GO:0045149)
Namespace: biological_process
Definition: The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source.
Synonyms: acetoin metabolism
acetoin catabolic process (GO:0045150)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone.
Synonyms: acetoin breakdown; acetoin catabolism; acetoin degradation
acetoin biosynthetic process (GO:0045151)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone.
Synonyms: acetoin anabolism; acetoin biosynthesis; acetoin formation; acetoin synthesis
antisigma factor binding (GO:0045152)
Namespace: molecular_function
Definition: Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator.
Synonyms: antisigma factor antagonist activity
obsolete electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity (GO:0045155)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex.
Synonyms: cytochrome; cytochrome c
Comment: This term was obsoleted because it was not clearly defined, it has no corresponding EC or RHEA.
obsolete electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity (GO:0045156)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis.
Synonyms: cytochrome; cytochrome bc1 complex
Comment: This term combines a function and a location.
obsolete electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity (GO:0045157)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis.
Comment: This term combines a function and a location.
obsolete electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity (GO:0045158)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II.
Comment: This term combines a function and a location.
myosin II binding (GO:0045159)
Namespace: molecular_function
Definition: Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
myosin I complex (GO:0045160)
Namespace: cellular_component
Definition: A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement.
neuronal ion channel clustering (GO:0045161)
Namespace: biological_process
Definition: The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.
clustering of voltage-gated sodium channels (GO:0045162)
Namespace: biological_process
Definition: The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization.
Synonyms: clustering of voltage gated sodium channels; clustering of voltage-dependent sodium channels; Nav channel clustering; voltage-gated sodium channel clustering
clustering of voltage-gated potassium channels (GO:0045163)
Namespace: biological_process
Definition: The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.
Synonyms: clustering of voltage gated potassium channels; clustering of voltage-dependent potassium channels; Kv channel clustering; voltage-gated potassium channel clustering
cell fate commitment (GO:0045165)
Namespace: biological_process
Definition: The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.
Comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.
asymmetric protein localization involved in cell fate determination (GO:0045167)
Namespace: biological_process
Definition: Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
Synonyms: asymmetric protein localisation involved in cell fate determination; asymmetric protein localization involved in cell fate commitment; asymmetric protein localization resulting in cell fate commitment; cell fate commitment, asymmetric protein localization
cell-cell signaling involved in cell fate commitment (GO:0045168)
Namespace: biological_process
Definition: Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.
Synonyms: cell fate commitment, cell-cell signaling; cell fate commitment, cell-cell signalling; cell-cell signaling during in cell fate commitment; cell-cell signaling resulting in cell fate commitment; cell-cell signalling during cell fate commitment; cell-cell signalling involved in cell fate specification; cell-cell signalling resulting in cell fate commitment
fusome (GO:0045169)
Namespace: cellular_component
Definition: A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle.
spectrosome (GO:0045170)
Namespace: cellular_component
Definition: A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome.
intercellular bridge (GO:0045171)
Namespace: cellular_component
Definition: A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
germline ring canal (GO:0045172)
Namespace: cellular_component
Definition: Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells.
O-sialoglycoprotein catabolic process (GO:0045173)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.
Synonyms: O-sialoglycoprotein breakdown; O-sialoglycoprotein catabolism; O-sialoglycoprotein degradation
glutathione dehydrogenase (ascorbate) activity (GO:0045174)
Namespace: molecular_function
Definition: Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
Synonyms: dehydroascorbate reductase activity; dehydroascorbic acid reductase activity; dehydroascorbic reductase activity; DHA reductase activity; GDOR; glutathione dehydroascorbate reductase activity; glutathione:dehydroascorbate oxidoreductase activity; glutathione:dehydroascorbic acid oxidoreductase activity
apical protein localization (GO:0045176)
Namespace: biological_process
Definition: Any process in which a protein is transported to, or maintained in, apical regions of the cell.
Synonyms: apical protein localisation; establishment and maintenance of apical protein localization; establishment and maintenance of protein localization in apical part of cell
apical part of cell (GO:0045177)
Namespace: cellular_component
Definition: The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
Synonyms: apical region of cell
basal part of cell (GO:0045178)
Namespace: cellular_component
Definition: The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
apical cortex (GO:0045179)
Namespace: cellular_component
Definition: The region that lies just beneath the plasma membrane on the apical edge of a cell.
basal cortex (GO:0045180)
Namespace: cellular_component
Definition: The region that lies just beneath the plasma membrane on the basal edge of a cell.
obsolete glutamate synthase activity, NAD(P)H as acceptor (GO:0045181)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+.
Synonyms: glutamate synthase activity, NADH or NADPH as acceptor
Comment: This term was obsoleted because it was an unnecessary grouping class.
translation regulator activity (GO:0045182)
Namespace: molecular_function
Definition: Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
translation factor activity, non-nucleic acid binding (GO:0045183)
Namespace: molecular_function
Definition: A translation regulator activity that does not involve binding to nucleic acids.
establishment of protein localization (GO:0045184)
Namespace: biological_process
Definition: The directed movement of a protein to a specific location.
Synonyms: establishment of protein localisation; protein positioning; protein recruitment
maintenance of protein location (GO:0045185)
Namespace: biological_process
Definition: Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
Synonyms: active protein retrieval; maintenance of protein localization; protein retention; protein sequestering
zonula adherens assembly (GO:0045186)
Namespace: biological_process
Definition: Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
regulation of circadian sleep/wake cycle, sleep (GO:0045187)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
Synonyms: regulation of sleep
obsolete connective tissue growth factor biosynthetic process (GO:0045189)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta.
Synonyms: connective tissue growth factor anabolism; connective tissue growth factor biosynthesis; connective tissue growth factor formation; connective tissue growth factor synthesis; CTGF biosynthesis
Comment: This term was obsoleted because it represent translation of a gene product, not a specific process.
isotype switching (GO:0045190)
Namespace: biological_process
Definition: The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Synonyms: class switch recombination; class switching; isotype switch recombination
Comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
regulation of isotype switching (GO:0045191)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of isotype switching.
Synonyms: regulation of class switch recombination; regulation of class switching; regulation of isotype switch recombination
obsolete low-density lipoprotein catabolic process (GO:0045192)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats.
Synonyms: LDL catabolic process; LDL catabolism; low-density lipoprotein breakdown; low-density lipoprotein catabolic process; low-density lipoprotein catabolism; low-density lipoprotein degradation
Comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
obsolete acetylated low-density lipoprotein catabolic process (GO:0045193)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins.
Synonyms: Ac-LDL catabolic process; Ac-LDL catabolism; acetylated low-density lipoprotein breakdown; acetylated low-density lipoprotein catabolic process; acetylated low-density lipoprotein catabolism; acetylated low-density lipoprotein degradation
Comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
obsolete oxidized low-density lipoprotein catabolic process (GO:0045194)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins.
Synonyms: Ox-LDL catabolic process; Ox-LDL catabolism; oxidized low-density lipoprotein breakdown; oxidized low-density lipoprotein catabolic process; oxidized low-density lipoprotein catabolism; oxidized low-density lipoprotein degradation
Comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
obsolete gallstone formation (GO:0045195)
Namespace: biological_process
Definition: OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile.
Synonyms: gallstone formation
Comment: This term was made obsolete because the process it represents is pathological.
establishment or maintenance of neuroblast polarity (GO:0045196)
Namespace: biological_process
Definition: Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
Synonyms: establishment and/or maintenance of neuroblast cell polarity
establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)
Namespace: biological_process
Definition: Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
establishment of epithelial cell apical/basal polarity (GO:0045198)
Namespace: biological_process
Definition: The specification and formation of the apicobasal polarity of an epithelial cell.
maintenance of epithelial cell apical/basal polarity (GO:0045199)
Namespace: biological_process
Definition: The maintenance of the apicobasal polarity of an epithelial cell.
establishment of neuroblast polarity (GO:0045200)
Namespace: biological_process
Definition: The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
Synonyms: establishment of neuroblast cell polarity
synapse (GO:0045202)
Namespace: cellular_component
Definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Synonyms: electrotonic synapse; mixed synapse; synaptic junction
obsolete integral component of cell outer membrane (GO:0045203)
Namespace: cellular_component
Definition: OBSOLETE. The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral to cell outer membrane; integral to external membrane; integral to outer membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.