LiteFold/GO huggingface dataset:
vesicle tethering to endoplasmic reticulum (GO:0099044)
Namespace: biological_process
Definition: The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.
viral extrusion (GO:0099045)
Namespace: biological_process
Definition: The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded.
clearance of foreign intracellular nucleic acids (GO:0099046)
Namespace: biological_process
Definition: A defense process that protects an organism from DNA or RNA from an invading organism.
CRISPR-cas system (GO:0099048)
Namespace: biological_process
Definition: A defense response of that serves to clear host cells of foreign DNA and RNA. It has three distinct stage: acquisition of foreign DNA by integration into CRISPR loci in the host chromosome, CRISPR RNA (crRNA) biogenesis, and target interference. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, which describes the nature of the loci.
clathrin coat assembly involved in endocytosis (GO:0099049)
Namespace: biological_process
Definition: The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation.
vesicle scission (GO:0099050)
Namespace: biological_process
Definition: The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane.
vesicle scission involved in endocytosis (GO:0099051)
Namespace: biological_process
Definition: The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane.
obsolete vesicle scission involved in clathrin-mediated endocytosis (GO:0099052)
Namespace: biological_process
Definition: OBSOLETE. The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
presynapse assembly (GO:0099054)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a presynapse.
Synonyms: presynapse biogenesis; presynaptic terminal assembly
obsolete integral component of postsynaptic membrane (GO:0099055)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of presynaptic membrane (GO:0099056)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral component of presynaptic plasma membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of presynaptic endocytic zone membrane (GO:0099057)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of postsynaptic endocytic zone membrane (GO:0099058)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of presynaptic active zone membrane (GO:0099059)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of postsynaptic specialization membrane (GO:0099060)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of postsynaptic density membrane (GO:0099061)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of postsynaptic early endosome membrane (GO:0099062)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of postsynaptic recycling endosome membrane (GO:0099063)
Namespace: cellular_component
Definition: OBSOLETE. The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of neuronal dense core vesicle membrane (GO:0099066)
Namespace: cellular_component
Definition: OBSOLETE. The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
obsolete integral component of presynaptic endosome membrane (GO:0099067)
Namespace: cellular_component
Definition: OBSOLETE. The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
postsynapse assembly (GO:0099068)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a postsynapse.
Synonyms: postsynapse biogenesis
synaptic vesicle tethering involved in synaptic vesicle exocytosis (GO:0099069)
Namespace: biological_process
Definition: The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion.
static microtubule bundle (GO:0099070)
Namespace: cellular_component
Definition: A microtubule bundle that has a constant length, and in which microtubule sliding does not take place.
Synonyms: Q-MT bundle; quiescent cell microtubule bundle; quiescent cell MT bundle
Comment: In fission yeast, quiescent cells contain only static microtubule bundles.
regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)
Namespace: biological_process
Definition: Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
mitochondrion-derived vesicle (GO:0099073)
Namespace: cellular_component
Definition: A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae.
Synonyms: MDV
mitochondrion to lysosome vesicle-mediated transport (GO:0099074)
Namespace: biological_process
Definition: Vesicle-mediated transport of cargo from the mitochondrion to the lysosome, mediated by a mitochondrion-derived vesicle.
Synonyms: mitochondrion to lysosome transport
mitochondrion-derived vesicle mediated transport (GO:0099075)
Namespace: biological_process
Definition: Vesicle-mediated transport of cargo from the mitochondrion by a mitochondrion-derived vesicle.
histone-dependent DNA binding (GO:0099077)
Namespace: molecular_function
Definition: DNA-binding activity that is dependent on binding to a histone.
BORC complex (GO:0099078)
Namespace: cellular_component
Definition: A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors.
supramolecular complex (GO:0099080)
Namespace: cellular_component
Definition: A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.
supramolecular polymer (GO:0099081)
Namespace: cellular_component
Definition: A polymeric supramolecular structure.
retrograde trans-synaptic signaling by neuropeptide (GO:0099082)
Namespace: biological_process
Definition: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission (GO:0099083)
Namespace: biological_process
Definition: Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
postsynaptic specialization organization (GO:0099084)
Namespace: biological_process
Definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
Synonyms: post synaptic specialization organization; post-synaptic specialization organization; postsynaptic specialization organisation
DIF dechlorinase activity (GO:0099085)
Namespace: molecular_function
Definition: Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one = 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-.
Synonyms: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity; 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity; DIF-1 3(5)-dechlorinase activity; DIF-1 dechlorinase activity; differentiation-inducing factor 1 dechlorinase activity; differentiation-inducing factor dechlorinase activity
synaptonemal structure (GO:0099086)
Namespace: cellular_component
Definition: A proteinaceous scaffold found between homologous chromosomes during meiosis.
anterograde axonal transport of messenger ribonucleoprotein complex (GO:0099087)
Namespace: biological_process
Definition: The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse.
Synonyms: anterograde axonal transport of mRNA RNP complex
axonal transport of messenger ribonucleoprotein complex (GO:0099088)
Namespace: biological_process
Definition: The directed movement of a messenger ribonucleoprotein complex along microtubules in axons.
Synonyms: axonal transport of mRNA RNP complex
establishment of endoplasmic reticulum localization to postsynapse (GO:0099089)
Namespace: biological_process
Definition: The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.
Synonyms: establishment of ER localization to postsynapse
postsynaptic specialization, intracellular component (GO:0099091)
Namespace: cellular_component
Definition: A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic density, intracellular component (GO:0099092)
Namespace: cellular_component
Definition: A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
calcium export from the mitochondrion (GO:0099093)
Namespace: biological_process
Definition: A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol.
Synonyms: calcium ion transmembrane export from mitochondrion; mitochondrial calcium ion export; mitochondrial calcium release
ligand-gated monoatomic anion channel activity (GO:0099095)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
Synonyms: ligand-gated anion channel activity
vestibular calyx terminal (GO:0099096)
Namespace: cellular_component
Definition: The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell.
microtubule polymerization based movement (GO:0099098)
Namespace: biological_process
Definition: The movement of a cellular component as a result of microtubule polymerization.
G-protein gated monoatomic cation channel activity (GO:0099100)
Namespace: molecular_function
Definition: A cation channel activity that is gated by binding of a G-protein beta-gamma dimer.
Synonyms: G-protein gated cation channel activity
G-protein gated potassium channel activity (GO:0099101)
Namespace: molecular_function
Definition: A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer.
obsolete G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential (GO:0099102)
Namespace: molecular_function
Definition: OBSOLETE. Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
channel activator activity (GO:0099103)
Namespace: molecular_function
Definition: Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.
Synonyms: channel gating activity
potassium channel activator activity (GO:0099104)
Namespace: molecular_function
Definition: Binds to and increases the activity of a potassium channel, resulting in its opening.
obsolete ion channel modulating, G protein-coupled receptor signaling pathway (GO:0099105)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel.
Synonyms: ion channel modulating, G-protein coupled receptor signaling pathway
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
ion channel regulator activity (GO:0099106)
Namespace: molecular_function
Definition: Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.
obsolete ion channel regulator activity involved in G protein-coupled receptor signaling pathway (GO:0099107)
Namespace: molecular_function
Definition: OBSOLETE. Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling.
Synonyms: ion channel regulator activity involved in G-protein coupled receptor signaling pathway
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
obsolete potassium channel activator activity involved in G protein-coupled receptor signaling pathway (GO:0099108)
Namespace: molecular_function
Definition: OBSOLETE. Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.
Synonyms: potassium channel activator activity involved in G-protein coupled receptor signaling pathway
Comment: The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
obsolete potassium channel activating, G protein-coupled receptor signaling pathway (GO:0099109)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel.
Synonyms: potassium channel activating, G-protein coupled receptor signaling pathway
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
microtubule polymerization based protein transport to cell tip cortex (GO:0099110)
Namespace: biological_process
Definition: The transport of a protein to the cortex of the cell tip, driven by polymerization of a microtubule to which the protein is attached.
microtubule-based transport (GO:0099111)
Namespace: biological_process
Definition: A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
negative regulation of presynaptic cytosolic calcium concentration (GO:0099113)
Namespace: biological_process
Definition: Any process that decreases the concentration of calcium ions in the presynaptic cytosol.
chromosome, subtelomeric region (GO:0099115)
Namespace: cellular_component
Definition: A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin.
Synonyms: nuclear subtelomeric heterochromatin; sub-telomeric heterochromatin; subtelomere; subtelomeric heterochromatin
tRNA 5'-end processing (GO:0099116)
Namespace: biological_process
Definition: The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA.
Synonyms: tRNA 5' processing
protein transport along microtubule to cell tip (GO:0099117)
Namespace: biological_process
Definition: The movement of a protein along a microtubule to the cell-tip, mediated by motor proteins.
microtubule-based protein transport (GO:0099118)
Namespace: biological_process
Definition: A microtubule-based process that results in the transport of proteins.
obsolete 3-demethylubiquinol-8 3-O-methyltransferase activity (GO:0099119)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8.
Comment: This term was obsoleted because it represents a specific substrate of 3-demethylubiquinol-n 3-O-methyltransferase activity ; GO:0061542.
socially cooperative development (GO:0099120)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies.
Synonyms: colonial development; non-reproductive fruiting body development; socially co-operative development
RNA polymerase II C-terminal domain binding (GO:0099122)
Namespace: molecular_function
Definition: Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function.
Synonyms: RNAP II C-terminal binding
somato-dendritic dopamine secretion (GO:0099123)
Namespace: biological_process
Definition: The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron.
Synonyms: somatodendritic dopamine release; STD DA release; STD dopamine release
axonal dopamine secretion (GO:0099124)
Namespace: biological_process
Definition: The regulated release of dopamine from an axon.
Synonyms: axonal DA release; axonal dopamine release
PAK family kinase-Sog2 complex (GO:0099125)
Namespace: cellular_component
Definition: A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network.
transforming growth factor beta complex (GO:0099126)
Namespace: cellular_component
Definition: A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP.
Synonyms: TGF-beta complex; TGF-beta dimer; TGFB complex; TGFB dimer; TGFbeta complex; TGFbeta dimer