LiteFold/GO huggingface dataset:
lipoprotein localization (GO:0044872)
Namespace: biological_process
Definition: Any process in which a lipoprotein is transported to, or maintained in, a specific location.
lipoprotein localization to membrane (GO:0044873)
Namespace: biological_process
Definition: A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane.
lipoprotein localization to outer membrane (GO:0044874)
Namespace: biological_process
Definition: A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.
gamma-glutamyl hercynylcysteine sulfoxide synthase activity (GO:0044875)
Namespace: molecular_function
Definition: Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O.
Synonyms: gamma-glutamyl hercynylcysteine S-oxide synthase; gamma-glutamyl hercynylcysteine sulfoxide synthase
obsolete hercynylselenocysteine synthase (GO:0044876)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 = 2 H2O + 2 hercynylselenocysteine.
Comment: This term was obsoleted based on PMID:36071162 that has demonstrated that this reaction does not take place.
protein-containing complex binding (GO:0044877)
Namespace: molecular_function
Definition: Binding to a macromolecular complex.
Synonyms: macromolecular complex binding; protein complex binding
mitotic cytokinesis checkpoint signaling (GO:0044878)
Namespace: biological_process
Definition: A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed.
Synonyms: cytokinesis after mitosis checkpoint; defective cytokinesis checkpoint; mitotic cytokinesis checkpoint; signal transduction involved in mitotic cytokinesis checkpoint; signaling pathway involved in mitotic cytokinesis checkpoint; signalling cascade involved in mitotic cytokinesis checkpoint; signalling pathway involved in mitotic cytokinesis checkpoint
mitotic morphogenesis checkpoint signaling (GO:0044879)
Namespace: biological_process
Definition: A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth.
Synonyms: morphogenesis checkpoint; septin checkpoint; signal transduction involved in morphogenesis checkpoint; signal transduction involved in septin checkpoint; signaling cascade involved in morphogenesis checkpoint; signaling cascade involved in septin checkpoint; signaling pathway involved in morphogenesis checkpoint; signaling pathway involved in septin checkpoint; signalling cascade involved in morphogenesis checkpoint; signalling cascade involved in septin checkpoint; signalling pathway involved in morphogenesis checkpoint; signalling pathway involved in septin checkpoint
double-strand break repair via single-strand annealing (GO:0045002)
Namespace: biological_process
Definition: Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.
double-strand break repair via synthesis-dependent strand annealing (GO:0045003)
Namespace: biological_process
Definition: SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.
Synonyms: mitotic gene conversion; SDSA
DNA replication proofreading (GO:0045004)
Namespace: biological_process
Definition: Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.
DNA-templated DNA replication maintenance of fidelity (GO:0045005)
Namespace: biological_process
Definition: A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.
Synonyms: DNA-dependent DNA replication maintenance of fidelity; maintenance of fidelity during DNA-dependent DNA replication; maintenance of fidelity involved in DNA-dependent DNA replication
DNA deamination (GO:0045006)
Namespace: biological_process
Definition: The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil.
depurination (GO:0045007)
Namespace: biological_process
Definition: The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.
depyrimidination (GO:0045008)
Namespace: biological_process
Definition: The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar.
actin nucleation (GO:0045010)
Namespace: biological_process
Definition: The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
Synonyms: actin filament nucleation
obsolete MHC class II receptor activity (GO:0045012)
Namespace: molecular_function
Definition: OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes.
Synonyms: class II major histocompatibility complex antigen; major histocompatibility complex class II receptor; MHC class II receptor activity
Comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'.
carbon catabolite repression of transcription (GO:0045013)
Namespace: biological_process
Definition: A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
Synonyms: carbon catabolite repression; negative regulation of transcription by carbon catabolites
carbon catabolite repression of transcription by glucose (GO:0045014)
Namespace: biological_process
Definition: A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
Synonyms: down regulation of transcription by glucose; down-regulation of transcription by glucose; downregulation of transcription by glucose; glucose effect; glucose repression; inhibition of transcription by glucose
HDEL sequence binding (GO:0045015)
Namespace: molecular_function
Definition: Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.
Synonyms: HDEL receptor activity
mitochondrial magnesium ion transmembrane transport (GO:0045016)
Namespace: biological_process
Definition: The process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
Synonyms: mitochondrial magnesium ion transport
glycerolipid biosynthetic process (GO:0045017)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone.
Synonyms: glycerolipid anabolism; glycerolipid biosynthesis; glycerolipid formation; glycerolipid synthesis
retrograde transport, vacuole to Golgi (GO:0045018)
Namespace: biological_process
Definition: The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment.
Synonyms: retrograde transport from the vacuole
negative regulation of nitric oxide biosynthetic process (GO:0045019)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
Synonyms: down regulation of nitric oxide biosynthetic process; down-regulation of nitric oxide biosynthetic process; downregulation of nitric oxide biosynthetic process; inhibition of nitric oxide biosynthetic process; negative regulation of nitric oxide anabolism; negative regulation of nitric oxide biosynthesis; negative regulation of nitric oxide formation; negative regulation of nitric oxide synthesis
obsolete error-prone DNA repair (GO:0045020)
Namespace: biological_process
Definition: OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate.
Synonyms: error-prone DNA repair; mutagenic DNA repair
Comment: This term was made obsolete because 'error-prone' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
obsolete error-free DNA repair (GO:0045021)
Namespace: biological_process
Definition: OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways.
Synonyms: error-free DNA repair
Comment: This term was made obsolete because 'error-free' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
early endosome to late endosome transport (GO:0045022)
Namespace: biological_process
Definition: The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
Synonyms: endosome maturation
G0 to G1 transition (GO:0045023)
Namespace: biological_process
Definition: The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.
obsolete peptidyl-glutamyl peptide hydrolyzing enzyme activity (GO:0045024)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids.
Synonyms: peptidyl-glutamyl peptide hydrolyzing enzyme activity
Comment: This term was made obsolete because it represents a gene product.
obsolete plasma membrane fusion (GO:0045026)
Namespace: biological_process
Definition: OBSOLETE. The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.
Synonyms: cell fusion; cell-cell fusion
Comment: This term is represented by another term.
DNA end binding (GO:0045027)
Namespace: molecular_function
Definition: Binding to DNA ends exposed by the creation of double-strand breaks (DSBs).
G protein-coupled purinergic nucleotide receptor activity (GO:0045028)
Namespace: molecular_function
Definition: Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G protein coupled purinergic nucleotide receptor activity; G-protein coupled purinergic nucleotide receptor activity; P2Y; P2Y receptor; purinergic nucleotide receptor activity, G protein coupled; purinergic nucleotide receptor activity, G-protein coupled
G protein-coupled UDP receptor activity (GO:0045029)
Namespace: molecular_function
Definition: Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP.
Synonyms: UDP-activated nucleotide receptor activity
G protein-coupled UTP receptor activity (GO:0045030)
Namespace: molecular_function
Definition: Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP.
Synonyms: purinoceptor type U; uridine nucleotide receptor activity; UTP-activated nucleotide receptor activity
G protein-coupled ATP receptor activity (GO:0045031)
Namespace: molecular_function
Definition: Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: ATP-activated adenosine receptor activity; ATP-activated nucleotide receptor activity
peroxisome inheritance (GO:0045033)
Namespace: biological_process
Definition: The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p.
Comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another.
obsolete neuroblast division (GO:0045034)
Namespace: biological_process
Definition: OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell.
Synonyms: neuroblast cell division; neuroblast division; neuroblast division (sensu Nematoda and Protostomia); neuroblast division (sensu Vertebrata)
Comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division.
sensory organ precursor cell division (GO:0045035)
Namespace: biological_process
Definition: The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron).
Synonyms: sense organ precursor cell division
protein targeting to chloroplast (GO:0045036)
Namespace: biological_process
Definition: The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved.
Synonyms: protein-chloroplast targeting
protein import into chloroplast stroma (GO:0045037)
Namespace: biological_process
Definition: The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import.
Synonyms: chloroplast stroma protein import; protein transport into chloroplast stroma
protein import into chloroplast thylakoid membrane (GO:0045038)
Namespace: biological_process
Definition: The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma.
Synonyms: chloroplast thylakoid membrane protein import; protein transport into chloroplast thylakoid membrane
protein insertion into mitochondrial inner membrane (GO:0045039)
Namespace: biological_process
Definition: The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane.
Synonyms: mitochondrial inner membrane protein import; protein import into mitochondrial inner membrane; protein transport into mitochondrial inner membrane
protein insertion into mitochondrial outer membrane (GO:0045040)
Namespace: biological_process
Definition: The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.
Synonyms: mitochondrial outer membrane protein import; protein import into mitochondrial outer membrane; protein transport into mitochondrial outer membrane
protein import into mitochondrial intermembrane space (GO:0045041)
Namespace: biological_process
Definition: The import of proteins into the space between the inner and outer mitochondrial membranes.
Synonyms: mitochondrial intermembrane space protein import; protein import into mitochondrial IMS; protein import into mitochondrial intermembrane space, direct; protein import into mitochondrial intermembrane space, nonconservative; protein transport into mitochondrial IMS; protein transport into mitochondrial intermembrane space
obsolete protein import into mitochondrial intermembrane space, conservative (GO:0045042)
Namespace: biological_process
Definition: OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space.
Synonyms: conservative mitochondrial IMS protein import; conservative mitochondrial intermembrane space protein import; conservative protein transport into mitochondrial IMS; conservative protein transport into mitochondrial intermembrane space; protein import into mitochondrial IMS, conservative; protein import into mitochondrial intermembrane space, conservative; protein transport into mitochondrial IMS, conservative; protein transport into mitochondrial intermembrane space, conservative
Comment: This term was made obsolete because there is no 'conservative' process of protein import into the mitochondrial intermembrane space that is distinct from the more general parent; furthermore, 'conservative' is used in the literature to describe a pathway of import into the inner membrane rather than into the intermembrane space.
obsolete secretory pathway (GO:0045045)
Namespace: biological_process
Definition: OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane.
Synonyms: secretory pathway
Comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations.
protein import into peroxisome membrane (GO:0045046)
Namespace: biological_process
Definition: The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import.
Synonyms: peroxisome membrane protein import; protein transport into peroxisome membrane
protein targeting to ER (GO:0045047)
Namespace: biological_process
Definition: The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
Synonyms: protein targeting to endoplasmic reticulum; protein-endoplasmic reticulum targeting; protein-ER targeting
protein insertion into ER membrane (GO:0045048)
Namespace: biological_process
Definition: The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
Synonyms: integral ER membrane protein localization; integral ER membrane protein positioning; localization of protein in ER membrane; positioning of protein in ER membrane; protein insertion into endoplasmic reticulum membrane; protein-endoplasmic reticulum insertion; protein-ER insertion
protein insertion into ER membrane by N-terminal cleaved signal sequence (GO:0045049)
Namespace: biological_process
Definition: A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER.
Synonyms: N-terminal cleaved signal sequence mediated protein insertion into ER membrane; protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence; protein insertion into ER membrane, N-terminal cleaved signal sequence mediated; protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence; protein-ER insertion by N-terminal cleaved signal sequence