LiteFold/GO huggingface dataset:
synaptic vesicle (GO:0008021)
Namespace: cellular_component
Definition: A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
Synonyms: docked vesicle
Comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.
obsolete protein C-terminus binding (GO:0008022)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
Synonyms: C-terminal binding; C-terminal end binding; carboxy-terminal binding; carboxy-terminus binding; carboxyl-terminal binding; carboxyl-terminus binding; carboxylate-terminal binding; carboxylate-terminus binding; COOH-terminal binding; COOH-terminus binding
Comment: It is out of GO scope.
cyclin/CDK positive transcription elongation factor complex (GO:0008024)
Namespace: cellular_component
Definition: A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
Synonyms: positive transcription elongation factor complex b
Comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
obsolete diazepam binding inhibitor activity (GO:0008025)
Namespace: molecular_function
Definition: OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters.
Synonyms: DBI; diazepam binding inhibitor activity; diazepam-binding inhibitor activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
monocarboxylic acid transmembrane transporter activity (GO:0008028)
Namespace: molecular_function
Definition: Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.
Synonyms: monocarboxylate carrier; prostaglandin/thromboxane transporter activity
pentraxin receptor activity (GO:0008029)
Namespace: molecular_function
Definition: Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: pentaxin receptor
Comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
eclosion hormone activity (GO:0008031)
Namespace: molecular_function
Definition: The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis.
tRNA processing (GO:0008033)
Namespace: biological_process
Definition: The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
Synonyms: tRNA maturation
obsolete lipoprotein binding (GO:0008034)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.
Synonyms: lipoprotein binding
Comment: This term was made obsolete because its text definition and implicit ontology-structure definition disagreed, and as a result the term had been used in annotations with more than one meaning.
high-density lipoprotein particle binding (GO:0008035)
Namespace: molecular_function
Definition: Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.
Synonyms: HDL binding
diuretic hormone receptor activity (GO:0008036)
Namespace: molecular_function
Definition: Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity.
cell recognition (GO:0008037)
Namespace: biological_process
Definition: The process in which a cell in an organism interprets its surroundings.
Synonyms: recognition of surroundings by cell
neuron recognition (GO:0008038)
Namespace: biological_process
Definition: The process in which a neuronal cell in a multicellular organism interprets its surroundings.
Synonyms: neuronal cell recognition
synaptic target recognition (GO:0008039)
Namespace: biological_process
Definition: The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
Synonyms: neuronal targeting
obsolete storage protein of fat body (sensu Insecta) (GO:0008041)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: storage protein of fat body (sensu Insecta)
Comment: This term was made obsolete because it describes a cellular location rather than a function.
obsolete intracellular ferritin complex (GO:0008043)
Namespace: cellular_component
Definition: OBSOLETE. A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
Comment: The reason for obsoletion is that this term represents a cellular component and its location.
obsolete adult behavior (sensu Insecta) (GO:0008044)
Namespace: biological_process
Definition: OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects.
Synonyms: adult behavior (sensu Insecta)
Comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
axon guidance receptor activity (GO:0008046)
Namespace: molecular_function
Definition: Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
Synonyms: receptor activity involved in axon guidance
enzyme activator activity (GO:0008047)
Namespace: molecular_function
Definition: A molecular function regulator that increases a catalytic activity.
Synonyms: metalloenzyme activator activity
Comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.
calcium sensitive guanylate cyclase activator activity (GO:0008048)
Namespace: molecular_function
Definition: Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
male courtship behavior (GO:0008049)
Namespace: biological_process
Definition: The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
Synonyms: male courtship behaviour
female courtship behavior (GO:0008050)
Namespace: biological_process
Definition: The behavior of a female, for the purpose of attracting a sexual partner.
Synonyms: female courtship behaviour
obsolete farnesyl-diphosphate farnesyl transferase complex (GO:0008051)
Namespace: cellular_component
Definition: OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity.
Synonyms: farnesyl-diphosphate farnesyl transferase complex
Comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer.
sensory organ boundary specification (GO:0008052)
Namespace: biological_process
Definition: The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained.
Synonyms: sense organ boundary specification
mitochondrial fusion (GO:0008053)
Namespace: biological_process
Definition: Merging of two or more mitochondria within a cell to form a single compartment.
Synonyms: mitochondrial membrane fusion; mitochondrion fusion
ocellus pigment biosynthetic process (GO:0008055)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.
Synonyms: ocellus pigment anabolism; ocellus pigment biosynthesis; ocellus pigment formation; ocellus pigment synthesis
ocellus development (GO:0008056)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.
eye pigment granule organization (GO:0008057)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.
Synonyms: eye pigment granule organisation; eye pigment granule organization and biogenesis
ocellus pigment granule organization (GO:0008058)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus.
Synonyms: ocellus pigment granule organisation; ocellus pigment granule organization and biogenesis
eclosion rhythm (GO:0008062)
Namespace: biological_process
Definition: The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.
Toll signaling pathway (GO:0008063)
Namespace: biological_process
Definition: The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: Tl signaling pathway; Tl signalling pathway; Toll signalling pathway
regulation of actin polymerization or depolymerization (GO:0008064)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
establishment of blood-nerve barrier (GO:0008065)
Namespace: biological_process
Definition: The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.
Synonyms: establishment of blood/nerve barrier
glutamate receptor activity (GO:0008066)
Namespace: molecular_function
Definition: Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
obsolete metabotropic glutamate, GABA-B-like receptor activity (GO:0008067)
Namespace: molecular_function
Definition: OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor.
Synonyms: class C G protein coupled receptor; class C G-protein coupled receptor; class C GPCR; class C orphan receptor activity; metabotropic glutamate, GABA-B-like receptor activity
Comment: This term was made obsolete because it represents a gene product and is named based on protein features.
extracellularly glutamate-gated chloride channel activity (GO:0008068)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Synonyms: extracellular-glutamate-gated chloride channel activity
Comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
dorsal/ventral axis specification, ovarian follicular epithelium (GO:0008069)
Namespace: biological_process
Definition: Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster.
Synonyms: dorsal-ventral axis specification, ovarian follicular epithelium; dorsal/ventral axis determination, follicular epithelium; dorsal/ventral axis determination, ovarian follicular epithelium; dorsoventral axis specification, ovarian follicular epithelium
maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded (GO:0008070)
Namespace: biological_process
Definition: Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line.
Synonyms: maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded; maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded
maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded (GO:0008071)
Namespace: biological_process
Definition: Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster.
Synonyms: maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded; maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded; maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded
ornithine decarboxylase inhibitor activity (GO:0008073)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.
guanylate cyclase complex, soluble (GO:0008074)
Namespace: cellular_component
Definition: Complex that possesses guanylate cyclase activity and is not bound to a membrane.
Comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'.
obsolete receptor guanylate cyclase activity (GO:0008075)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
Synonyms: receptor guanylate cyclase activity
Comment: This term was made obsolete because it represents a class of gene products.
voltage-gated potassium channel complex (GO:0008076)
Namespace: cellular_component
Definition: A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
Synonyms: voltage gated potassium channel complex; voltage-dependent potassium channel complex; voltage-sensitive potassium channel complex
obsolete Hsp70/Hsp90 organizing protein activity (GO:0008077)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: Hsp70/Hsp90 organising protein activity; Hsp70/Hsp90 organizing protein activity
Comment: This term was made obsolete because it represents a specific gene product rather than a molecular function.
mesodermal cell migration (GO:0008078)
Namespace: biological_process
Definition: The orderly movement of mesodermal cells from one site to another.
Synonyms: mesoderm cell migration
N-acetyltransferase activity (GO:0008080)
Namespace: molecular_function
Definition: Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
phosphoric diester hydrolase activity (GO:0008081)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
Synonyms: phosphodiesterase
light-activated voltage-gated calcium channel complex (GO:0008087)
Namespace: cellular_component
Definition: A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus.
Synonyms: light-activated voltage gated calcium channel complex; light-activated voltage-dependent calcium channel complex; light-activated voltage-sensitive calcium channel complex
axo-dendritic transport (GO:0008088)
Namespace: biological_process
Definition: The directed movement of organelles or molecules along microtubules in neuron projections.
Synonyms: axon cargo transport; axonal transport; axoplasmic transport
anterograde axonal transport (GO:0008089)
Namespace: biological_process
Definition: The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
Synonyms: anterograde axon cargo transport
retrograde axonal transport (GO:0008090)
Namespace: biological_process
Definition: The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
Synonyms: retrograde axon cargo transport
spectrin (GO:0008091)
Namespace: cellular_component
Definition: Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
cytoskeletal protein binding (GO:0008092)
Namespace: molecular_function
Definition: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
cytoskeletal anchor activity (GO:0008093)
Namespace: molecular_function
Definition: The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way.
Synonyms: cytoskeletal adaptor activity
ATP-dependent activity, acting on DNA (GO:0008094)
Namespace: molecular_function
Definition: Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
Synonyms: adenosinetriphosphatase (DNA-dependent); ATPase activity, acting on DNA; ATPase, acting on DNA; DNA dependent ATPase activity; DNA-dependent adenosinetriphosphatase activity; DNA-dependent ATPase activity
juvenile hormone epoxide hydrolase activity (GO:0008096)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol.
5S rRNA binding (GO:0008097)
Namespace: molecular_function
Definition: Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome.
5S rRNA primary transcript binding (GO:0008098)
Namespace: molecular_function
Definition: Binding to an unprocessed 5S ribosomal RNA transcript.
obsolete lipophorin (GO:0008100)
Namespace: molecular_function
Definition: OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects.
Synonyms: lipophorin
Comment: This term was made obsolete because it represents a class of gene products.
oocyte microtubule cytoskeleton polarization (GO:0008103)
Namespace: biological_process
Definition: Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster.
intracellular protein localization (GO:0008104)
Namespace: biological_process
Definition: Any process in which a protein is transported to, or maintained in, a specific location.
Synonyms: asymmetric protein localisation; asymmetric protein localization; cellular protein localisation; cellular protein localization; channel localizer activity; establishment and maintenance of asymmetric protein localization; establishment and maintenance of protein localization; protein localisation; protein localization
UDP-glucose:hexose-1-phosphate uridylyltransferase activity (GO:0008108)
Namespace: molecular_function
Definition: Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.
Synonyms: Gal-1-P uridylyltransferase activity; galactose-1-phosphate uridylyltransferase activity; hexose 1-phosphate uridyltransferase activity; hexose-1-phosphate uridylyltransferase activity; UDP-glucose-hexose-1-phosphate uridylyltransferase activity; UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity; UDPglucose-hexose-1-phosphate uridylyltransferase activity; UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity; uridyl transferase activity; uridyltransferase activity; uridylyl removing enzyme activity
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity (GO:0008109)
Namespace: molecular_function
Definition: Catalysis of the reaction: a beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl derivative + UDP + H+.
Synonyms: galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity; N-acetylglucosaminyltransferase activity; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity; UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity; UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity; uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase
L-histidine:2-oxoglutarate transaminase activity (GO:0008110)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-histidine + 2-oxoglutarate = 3-(imidazol-5-yl)pyruvate + L-glutamate.
Synonyms: histidine aminotransferase activity; histidine transaminase activity; histidine-2-oxoglutarate aminotransferase activity; L-histidine:2-oxoglutarate aminotransferase activity
alpha-methylacyl-CoA racemase activity (GO:0008111)
Namespace: molecular_function
Definition: Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.
Synonyms: 2-methylacyl-CoA 2-epimerase activity
phosphogluconate 2-dehydrogenase activity (GO:0008114)
Namespace: molecular_function
Definition: Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH.
Synonyms: 2-keto-6-phosphogluconate reductase activity; 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity; 6-phosphogluconate 2-dehydrogenase activity; 6-phosphogluconate dehydrogenase (NAD); 6-phosphogluconic dehydrogenase activity; gluconate 6-phosphate dehydrogenase activity; phosphogluconate dehydrogenase activity
sarcosine oxidase activity (GO:0008115)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2.
Synonyms: sarcosine:oxygen oxidoreductase (demethylating)
prostaglandin-I synthase activity (GO:0008116)
Namespace: molecular_function
Definition: Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).
Synonyms: (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity; cytochrome P450 CYP8A1; PGI(2) synthase activity; PGI(2) synthetase activity; PGI2 synthase activity; PGI2 synthetase activity; prostacyclin synthase activity; prostacycline synthetase activity; prostagladin I2 synthetase activity