LiteFold/GO huggingface dataset:
sphinganine-1-phosphate aldolase activity (GO:0008117)
Namespace: molecular_function
Definition: Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
Synonyms: dihydrosphingosine 1-phosphate aldolase activity; sphinganine-1-phosphate alkanal-lyase activity; sphinganine-1-phosphate lyase activity; sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming); sphinganine-1-phosphate palmitaldehyde-lyase activity; sphingosine-1-phosphate aldolase activity; sphingosine-1-phosphate lyase activity
N-acetyllactosaminide alpha-2,3-sialyltransferase activity (GO:0008118)
Namespace: molecular_function
Definition: Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H+.
Synonyms: alpha2->3 sialyltransferase activity; cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity; N-acetyllactosaminide alpha-2,3-sialyltransferase; neolactotetraosylceramide alpha-2,3-sialyltransferase activity
Comment: The substrate for this reaction is a beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
thiopurine S-methyltransferase activity (GO:0008119)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.
Synonyms: 6-thiopurine transmethylase activity; mercaptopurine methyltransferase activity; S-adenosyl-L-methionine:thiopurine S-methyltransferase activity; thiopurine methyltransferase activity; TPMT
ceramide glucosyltransferase activity (GO:0008120)
Namespace: molecular_function
Definition: Catalysis of the reaction: an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H+ + UDP.
Synonyms: ceramide:UDP-glucose glucosyltransferase activity; ceramide:UDPGlc glucosyltransferase activity; glucosylceramide synthase activity; UDP-glucose-ceramide glucosyltransferase activity; UDP-glucose:ceramide glucosyltransferase activity; UDP-glucose:N-acylsphingosine D-glucosyltransferase activity; UDPglucose:N-acylsphingosine D-glucosyltransferase activity; uridine diphosphoglucose-ceramide glucosyltransferase activity
quinol-cytochrome-c reductase activity (GO:0008121)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: a quinol + 2 Fe(III)-cytochrome c = a quinone + 2 Fe(II)-cytochrome c + 2 H+(out).
Synonyms: complex III (mitochondrial electron transport) activity; cytochrome; cytochrome a; cytochrome a3/copper complex; cytochrome b562; cytochrome b566; cytochrome c1; electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity; electron transporter, transferring electrons within cytochrome c oxidase complex activity; mitochondrial electron transport complex III; soluble cytochrome b562; ubiquinol-cytochrome c oxidoreductase activity; ubiquinol-cytochrome c-2 oxidoreductase activity; ubiquinol-cytochrome c1 oxidoreductase activity; ubiquinol-cytochrome c2 reductase activity; ubiquinol-cytochrome-c reductase activity; ubiquinol:ferricytochrome-c oxidoreductase activity; ubiquinone--cytochrome-c oxidoreductase activity; ubiquinone-cytochrome c oxidoreductase activity; ubiquinone-cytochrome c reductase activity
cholesterol 7-alpha-monooxygenase activity (GO:0008123)
Namespace: molecular_function
Definition: Catalysis of the reaction: cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
Synonyms: cholesterol 7-alpha-hydroxylase activity; cholesterol 7alpha-hydroxylase activity; cholesterol 7alpha-monooxygenase activity; cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating); cytochrome P450 CYP7A1
4-alpha-hydroxytetrahydrobiopterin dehydratase activity (GO:0008124)
Namespace: molecular_function
Definition: Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.
Synonyms: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]; 4-alpha-hydroxy-tetrahydropterin dehydratase activity; 4a-hydroxytetrahydrobiopterin dehydratase activity; 4a-hydroxytetrahydrobiopterin hydro-lyase activity; 4alpha-hydroxy-tetrahydropterin dehydratase activity; pterin-4-alpha-carbinolamine dehydratase activity; pterin-4a-carbinolamine dehydratase activity; pterin-4alpha-carbinolamine dehydratase activity; tetrahydrobiopterin dehydratase activity
acetylesterase activity (GO:0008126)
Namespace: molecular_function
Definition: Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate.
Synonyms: acetic ester hydrolase activity; acetic-ester acetylhydrolase activity; C-esterase (in animal tissues); chloroesterase; citrus acetylesterase; p-nitrophenyl acetate esterase
quercetin 2,3-dioxygenase activity (GO:0008127)
Namespace: molecular_function
Definition: Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO.
Synonyms: flavonol 2,4-oxygenase activity; quercetin:oxygen 2,3-oxidoreductase (decyclizing); quercetinase activity
obsolete actinidain activity (GO:0008129)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'.
Synonyms: actinidain activity; actinidia anionic protease activity; actinidin activity; proteinase A2 of actinidia chinensis
Comment: This term was made obsolete because it represents a gene product.
primary methylamine oxidase activity (GO:0008131)
Namespace: molecular_function
Definition: Catalysis of the reaction: a primary methyl amine + H2O + O2 = an aldehyde + H2O2 + NH4+.
Synonyms: amine oxidase (copper-containing) activity; amine oxidase activity; primary amine oxidase activity; primary-amine:oxygen oxidoreductase (deaminating) activity
obsolete pancreatic elastase activity (GO:0008132)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin.
Synonyms: pancreatic elastase activity
Comment: This term was made obsolete because it represents a gene product.
obsolete collagenase activity (GO:0008133)
Namespace: molecular_function
Definition: OBSOLETE. Was not defined before being made obsolete.
Synonyms: collagenase activity
Comment: This term was made obsolete because it represents a gene product.
transcription factor binding (GO:0008134)
Namespace: molecular_function
Definition: Binding to a transcription factor, a protein required to initiate or regulate transcription.
Synonyms: TF binding; transcription regulator binding
Comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.
NADH dehydrogenase (ubiquinone) activity (GO:0008137)
Namespace: molecular_function
Definition: Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
Synonyms: coenzyme Q reductase activity; complex 1 dehydrogenase activity; complex I (electron transport chain) activity; complex I (mitochondrial electron transport) activity; complex I (NADH:Q1 oxidoreductase) activity; dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity; DPNH-coenzyme Q reductase activity; DPNH-ubiquinone reductase activity; electron transfer complex I activity; mitochondrial electron transport complex 1 activity; mitochondrial electron transport complex I activity; NADH coenzyme Q1 reductase activity; NADH-coenzyme Q oxidoreductase activity; NADH-coenzyme Q reductase activity; NADH-CoQ oxidoreductase activity; NADH-CoQ reductase activity; NADH-Q6 oxidoreductase activity; NADH-ubiquinone oxidoreductase activity; NADH-ubiquinone reductase activity; NADH-ubiquinone-1 reductase activity; NADH:ubiquinone oxidoreductase activity; NADH:ubiquinone oxidoreductase complex activity; reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity; type 1 dehydrogenase activity; ubiquinone reductase activity
protein tyrosine/serine/threonine phosphatase activity (GO:0008138)
Namespace: molecular_function
Definition: Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Synonyms: dual-specificity protein phosphatase
nuclear localization sequence binding (GO:0008139)
Namespace: molecular_function
Definition: Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
Synonyms: NLS binding; nuclear localisation sequence binding; nuclear localization signal binding
oxysterol binding (GO:0008142)
Namespace: molecular_function
Definition: Binding to oxysterol, an oxidized form of cholesterol.
poly(A) binding (GO:0008143)
Namespace: molecular_function
Definition: Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
Synonyms: poly(A) binding, within an RNA molecule; poly(rA) binding; poly-A binding; polyadenylate binding
obsolete drug binding (GO:0008144)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a drug, a naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism;typically used in the diagnosis, prevention, or treatment of disease.
Comment: It is not meaningful to describe a molecular function by what role a compound may be used for at some times.
phenylalkylamine binding (GO:0008145)
Namespace: molecular_function
Definition: Binding to phenylalkylamine or one of its derivatives.
sulfotransferase activity (GO:0008146)
Namespace: molecular_function
Definition: Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
Synonyms: sulphotransferase activity
structural constituent of bone (GO:0008147)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of bone.
obsolete negative transcription elongation factor activity (GO:0008148)
Namespace: molecular_function
Definition: OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.
Synonyms: negative transcription elongation factor activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
obsolete para-aminobenzoic acid (PABA) synthase (GO:0008149)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: para-aminobenzoic acid (PABA) synthase
Comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered.
biological_process (GO:0008150)
Namespace: biological_process
Definition: A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
Synonyms: biological process; physiological process; single organism process; single-organism process
Comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
metabolic process (GO:0008152)
Namespace: biological_process
Definition: A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well  macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
Synonyms: metabolism
Comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
4-aminobenzoate biosynthetic process (GO:0008153)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.
Synonyms: 4-aminobenzoic acid biosynthesis; 4-aminobenzoic acid biosynthetic process; p-aminobenzoic acid biosynthesis; p-aminobenzoic acid biosynthetic process; PABA biosynthesis; PABA biosynthetic process; para-aminobenzoic acid anabolism; para-aminobenzoic acid biosynthesis; para-aminobenzoic acid biosynthetic process; para-aminobenzoic acid formation; para-aminobenzoic acid synthesis; vitamin Bx biosynthesis; vitamin Bx biosynthetic process
negative regulation of DNA replication (GO:0008156)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.
Synonyms: DNA replication inhibitor; down regulation of DNA replication; down-regulation of DNA replication; downregulation of DNA replication; inhibition of DNA replication
protein phosphatase 1 binding (GO:0008157)
Namespace: molecular_function
Definition: Binding to a protein phosphatase 1.
hedgehog receptor activity (GO:0008158)
Namespace: molecular_function
Definition: Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.
Synonyms: patched activity
obsolete positive transcription elongation factor activity (GO:0008159)
Namespace: molecular_function
Definition: OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.
Synonyms: positive transcription elongation factor activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
protein tyrosine phosphatase activator activity (GO:0008160)
Namespace: molecular_function
Definition: Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.
obsolete carbamate resistance (GO:0008161)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: carbamate resistance
Comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
obsolete cyclodiene resistance (GO:0008162)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: cyclodiene resistance
Comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
obsolete organophosphorus resistance (GO:0008164)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: organophosphorus resistance
Comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
obsolete viral replication (GO:0008166)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: viral replication
Comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms.
obsolete sigma virus replication (GO:0008167)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: sigma virus replication
methyltransferase activity (GO:0008168)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group to an acceptor molecule.
Synonyms: methylase
C-methyltransferase activity (GO:0008169)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule.
N-methyltransferase activity (GO:0008170)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
O-methyltransferase activity (GO:0008171)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.
S-methyltransferase activity (GO:0008172)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.
RNA methyltransferase activity (GO:0008173)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
mRNA methyltransferase activity (GO:0008174)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.
tRNA methyltransferase activity (GO:0008175)
Namespace: molecular_function
Definition: Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside.
tRNA (guanine(46)-N7)-methyltransferase activity (GO:0008176)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine.
Synonyms: 7-methylguanine transfer ribonucleate methylase activity; N7-methylguanine methylase activity; tRNA (guanine(46)-N7-)-methyltransferase activity; tRNA (guanine-N7-)-methyltransferase activity; tRNA (guanosine(46)-N(7))-methyltransferase activity; tRNA (guanosine(46)-N7)-methyltransferase activity; tRNA (guanosine(46)-N7-)-methyltransferase activity; tRNA guanine 7-methyltransferase activity
succinate dehydrogenase (quinone) activity (GO:0008177)
Namespace: molecular_function
Definition: Catalysis of the reaction: a quinone + succinate = a quinol + fumarate.
Synonyms: fumarate reductase (menaquinone); succinate dehydrogenase (menaquinone); succinate dehydrogenase (ubiquinone) activity; succinic dehydrogenase activity
Comment: This term represents the overall reaction of the entire SDH complex.
adenylate cyclase binding (GO:0008179)
Namespace: molecular_function
Definition: Binding to an adenylate cyclase.
Synonyms: adenylyl cyclase binding
COP9 signalosome (GO:0008180)
Namespace: cellular_component
Definition: A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Synonyms: COP9 complex; CSN; signalosome
obsolete tumor suppressor (GO:0008181)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: tumor suppressor
Comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way.
glycogen phosphorylase activity (GO:0008184)
Namespace: molecular_function
Definition: Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.
ATP-dependent activity, acting on RNA (GO:0008186)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
Synonyms: ATPase activity, acting on RNA; ATPase, acting on RNA; RNA-dependent adenosinetriphosphatase activity; RNA-dependent ATPase activity
poly-pyrimidine tract binding (GO:0008187)
Namespace: molecular_function
Definition: Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule.