LiteFold/GO huggingface dataset:
D-alanine-(R)-lactate ligase activity (GO:0160220)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate.
Synonyms: D-alanyl-D-lactate ligase activity
Rho-activating G protein-coupled receptor signaling pathway (GO:0160221)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of Rho activity. Rho is a family of small (~21 kDa) signaling G proteins that include RhoA, Cdc42, and Rac1.
D-alanine-D-serine ligase activity (GO:0160222)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H+ + phosphate.
pyrenoid tubule (GO:0160223)
Namespace: cellular_component
Definition: A specialized membranous structure that extends from the photosynthetic thylakoid membrane into and transverses the matrix of a pyrenoid.
Synonyms: thylakoid membrane tubule
3-demethoxyubiquinone 3-hydroxylase (NADH) activity (GO:0160224)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone + NADH + O2 = a 3-demethylubiquinone + NAD+ + H2O.
Synonyms: 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone,NADH:oxygen oxidoreductase (5-hydroxylating) activity
G-quadruplex unwinding activity (GO:0160225)
Namespace: molecular_function
Definition: Unwinding G-quadruplex structures in nucleic acids. A G-quadruplex is a specialized structure formed in DNA/RNA when sequences rich in guanine (G) assemble into a unique four-stranded arrangement.
Synonyms: G-quadruplex resolving activity; G4 unwinding activity
oligosaccharyltransferase complex A (GO:0160226)
Namespace: cellular_component
Definition: An oligosaccharyltransferase complex that contains STT3A as the catalytic subunit.
Synonyms: OST-A
oligosaccharyltransferase complex B (GO:0160227)
Namespace: cellular_component
Definition: An oligosaccharyltransferase complex that contains STT3B as the catalytic subunit.
Synonyms: OST-B
bile acid-gated sodium channel activity (GO:0160228)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a sodium ion by a channel that opens when bile acid has been bound by the channel complex or one of its constituent parts.
peroxisome-endoplasmic reticulum membrane tether activity (GO:0160229)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a peroxisome and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein.
U6 snRNA (guanine-N(2))-methyltransferase activity (GO:0160230)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine in U6 snRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine.
cytospinule (GO:0160231)
Namespace: cellular_component
Definition: An actin-based cell projection extending laterally from the basolateral membrane of tuft cells in epithelial tissues, including the intestinal epithelium. These thin projections, typically 3-4 per cell and up to 3 micron long, directly contact the nuclei of adjacent epithelial cells, potentially facilitating intercellular communication and molecular exchange.
INTAC complex (GO:0160232)
Namespace: cellular_component
Definition: A protein complex containing Integrator and protein phosphatase 2A core enzyme (PP2A-AC) that stably associates with the C-terminus of RNA polymerase II and promotes premature RNA polymerase II transcription termination.
Synonyms: integrator-PP2A complex
valine sensor activity (GO:0160233)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of valine.
integrator complex assembly (GO:0160234)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form the integrator complex.
tRNA 5-taurinomethyluridine synthase activity (GO:0160236)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + taurine + GTP + H2O + uridine34 in tRNA + A = 7,8-dihydrofolate + GDP + phosphate + 5-taurinomethyluridine34 in tRNA + H+ + AH2.
D-Ala-D-Ala dipeptidase activity (GO:0160237)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-alanyl-D-alanine + H2O = 2 D-alanine.
Synonyms: D-alanyl-D-alanine dipeptidase activity
long-chain fatty aldehyde oxidative decarbonylase activity (GO:0160238)
Namespace: molecular_function
Definition: Catalysis of the reaction: reduced [NADPH-hemoprotein reductase] + O2 + a long-chain fatty aldehyde = oxidized [NADPH-hemoprotein reductase] + CO2 + H2O + H+ + a long-chain alkane.
Synonyms: aldehyde oxidative decarbonylase activity
transcription pausing by RNA polymerase II (GO:0160239)
Namespace: biological_process
Definition: A transcription halt following transcription initiation but prior to elongation, during which RNA polymerase II pauses approximately 20-60 nucleotides downstream of the transcriptional start site before proceeding into productive elongation. Transcription pausing starts following phosphorylation of the C-terminal domain (CTD) of RNA polymerase II subunit POLR2A at Ser-5 and stops following phosphorylation of POLR2A by the P-TEFb complex.
Synonyms: promoter proximal pausing by RNA polymerase II
cardiolipin dehydrogenase (NAD+) activity (GO:0160241)
Namespace: molecular_function
Definition: Catalysis of the reaction: a cardiolipin + NAD+ = a diphosphatidylglycerone + NADH + H+.
phosphatidylglycerol dehydrogenase (NAD+) activity (GO:0160242)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + NAD+ = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerone) + NADH + H+.
histone H1 demethylase activity (GO:0160243)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from a modified lysine residue of the histone H1 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
detoxification of sulfite (GO:0160245)
Namespace: biological_process
Definition: Any process that reduces or removes the toxicity of sulfite. These include transport of sulfite away from sensitive areas and to compartments or complexes whose purpose is sequestration of sulfite.
Synonyms: sulfite detoxification
NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity (GO:0160246)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP+ + H+.
autophagy cargo adaptor activity (GO:0160247)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a cargo, targeted for degradation via autophagy, to a phagophore.
Synonyms: autophagy adaptor activity; selective autophagy receptor activity
tRNA (guanine(27)-N2)-dimethyltransferase activity (GO:0160248)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine(27) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(27) in tRNA + 2 S-adenosyl-L-homocysteine.
glycogen biosynthetic process via UDP-glucose (GO:0160249)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues, occurring through a UDP-glucose intermediate.
glycogen biosynthetic process via ADP-glucose (GO:0160250)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues, occurring through a ADP-glucose intermediate.
glycogen catabolic process via dextrin (GO:0160251)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues, occurring through dextrin derivative intermediates.
glycogen catabolic process via dextrin and maltose (GO:0160252)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues, occurring through dextrin and maltose derivative intermediates.
de novo tRNA queuosine(34) biosynthetic process (GO:0160253)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of tRNA queuosine(34) from guanosine triphosphate (GTP).
tRNA queuosine(34) biosynthetic process from salvaged queuosine or its precursors (GO:0160254)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of tRNA queuosine(34) by salvaging available queuosine or precursors of queuosine (preQ0 or preQ1).
L-lysine transmembrane import into the mitochondrion (GO:0160256)
Namespace: biological_process
Definition: The process in which L-lysine is transported from the cytosol into the mitochondrial matrix.
complement activation, GZMK pathway (GO:0160257)
Namespace: biological_process
Definition: Any process involved in the activation of any of the steps of the granzyme K pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms: complement activation, granzyme K pathway
endoplasmic reticulum membrane-lipid droplet contact site (GO:0160259)
Namespace: cellular_component
Definition: A membrane contact site between the endoplasmic reticulum (ER) membrane and the lipid droplet.
Synonyms: bridging endoplasmic reticulum-lipid droplet contact; ER-LD contact site
protein asparagine deamidase activity (GO:0160260)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-asparaginyl-[protein] + H2O = L-aspartyl-[protein] + NH4+.
histone H1 asparagine deamidase activity (GO:0160261)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H1 L-asparagine + H2O = histone H1 L-aspartate + NH4+.
histone H1 acetyltransferase activity (GO:0160262)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + histone H1 = CoA + acetyl-histone H1.
histone H1K75 acetyltransferase activity (GO:0160263)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + histone H1 L-lysine (position 75) = CoA + histone H1 N6-acetyl-L-lysine (position 75).
histone H1N76/N77 asparagine deamidase activity (GO:0160264)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H1 L-asparagine [positions 76 and 77] + H2O = histone H1 L-aspartate [positions 76 and 77] + NH4+.
O-fucosylpeptide 3-beta-glucosyltransferase activity (GO:0160265)
Namespace: molecular_function
Definition: Catalysis of the transfer of a alpha-D-glucose residue from UDP-alpha-D-glucose to the fucose residue of a fucosylated protein acceptor.
anestrus phase (GO:0160266)
Namespace: biological_process
Definition: A biological phase of reproductive dormancy characterized by the temporary cessation of reproductive cyclicity, marked by the absence of ovarian follicular development, estrous behavior, and ovulation. This phase represents a period of sexual quiescence between estrous cycles or breeding seasons.
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
histone H1K26me1 reader activity (GO:0160267)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H1 monomethylated at lysine 26.
histone H1K26me2 reader activity (GO:0160268)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H1 dimethylated at lysine 26.
sweat secretion (GO:0160269)
Namespace: biological_process
Definition: The regulated release of sweat from the sweat glands.
Synonyms: perspiration; perspiring; sweating
phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity (GO:0160270)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out). This reaction results in the exchange of phosphatidylserine (PS) for phosphatidylinositol-4-phosphate (PI(4)P) between membranes.
FERRY complex (GO:0160271)
Namespace: cellular_component
Definition: A protein complex that directly interacts with mRNAs and Rab5, functions as a Rab5 effector, recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction, is composed of five subunits, TBCK, PPP1R21, FERRY3, CRYZL1 and GATD1 with a ratio of 1:2:1:2:4, respectively.
Synonyms: FERRY RAB5 effector complex; five-subunit endosomal Rab5 complex; RNA/ribosome intermediary complex
RNA 2',3'-cyclic phosphatase activity (GO:0160272)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + 2 H2O = a 3'-end ribonucleotide-RNA + phosphate + H+.
RNA 2'-phosphatase activity (GO:0160273)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + a 3'-end 2'-phospho-ribonucleotide-RNA = a 3'-end ribonucleotide-RNA + phosphate.
Synonyms: Ribonucleic acid 2'-phosphatase activity; RNA 2'-Pase activity
beige fat cell differentiation (GO:0160274)
Namespace: biological_process
Definition: The process in which a white fat cell acquires specialized features of a beige adipocyte. Beige adipocytes reside within white adipose tissue and can be induced to produce heat in response to cold exposure or certain stimuli, resembling brown adipocytes.
Synonyms: brite fat cell differentiation; brown-in white fat cell differentiation
negative regulation of white fat cell differentiation (GO:0160275)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of white fat cell differentiation.
negative regulation of beige fat cell differentiation (GO:0160276)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of beige fat cell differentiation.
cytoplasmic side of cis-Golgi cisternae membrane (GO:0160278)
Namespace: cellular_component
Definition: The leaflet of the cis-Golgi cisternae membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site of interactions with cytosolic proteins, including those involved in vesicle budding, membrane tethering, and lipid or protein trafficking.
Synonyms: cytoplasmic face of cis-Golgi cisternae membrane; cytoplasmic leaflet of cis-Golgi cisternae membrane
cytoplasmic side of medial-Golgi cisterna membrane (GO:0160279)
Namespace: cellular_component
Definition: The leaflet of the medial-Golgi cisternae membrane that faces the cytoplasm,including any protein embedded in, attached to, or peripherally associated with it. This is the site of interactions with cytosolic proteins involved in membrane trafficking, vesicle docking, and cargo sorting.
Synonyms: cytoplasmic face of Golgi medial cisterna membrane; cytoplasmic leaflet of Golgi medial cisterna membrane
lumenal side of medial-Golgi cisterna membrane (GO:0160280)
Namespace: cellular_component
Definition: The leaflet of the medial-Golgi cisternae membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where protein glycosylation occur.
Synonyms: lumenal face of medial-Golgi cisterna membrane; lumenal leaflet of Golgi medial cisterna membrane
cytoplasmic side of trans-Golgi network membrane (GO:0160281)
Namespace: cellular_component
Definition: The leaflet of the trans-Golgi network membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site of interaction where cytoplasmic proteins interact with proteins involved in vesicle formation and targeting.
Synonyms: cytoplasmic face of trans-Golgi network membrane; cytoplasmic leaflet of trans-Golgi network membrane; cytoplasmic side of trans-Golgi network
lumenal side of trans-Golgi network membrane (GO:0160282)
Namespace: cellular_component
Definition: The leaflet of the trans-Golgi network membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it.
Synonyms: lumenal face of trans-Golgi network membrane; lumenal leaflet of trans-Golgi network membrane; lumenal side of trans-Golgi network
queuine transmembrane transporter activity (GO:0160283)
Namespace: molecular_function
Definition: Enables the transfer of queuine from one side of a membrane to the other according to the reaction: queuine(out) = queuine(in).
queuine import across plasma membrane (GO:0160284)
Namespace: biological_process
Definition: The directed movement of queuine from outside of a cell, across the plasma membrane and into the cytosol.
queuosine transmembrane transporter activity (GO:0160286)
Namespace: molecular_function
Definition: Enables the transfer of queuosine from one side of a membrane to the other according to the reaction: queuosine(out) = queuosine(in).
queuosine import across plasma membrane (GO:0160287)
Namespace: biological_process
Definition: The directed movement of queuosine from outside of a cell, across the plasma membrane and into the cytosol.
cytoplasmic side of trans-Golgi cisterna membrane (GO:0160288)
Namespace: cellular_component
Definition: The leaflet of the trans-Golgi cisternae membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site where vesicle formation, and cargo sorting towards post-Golgi destinations such as endosomes, lysosomes and the plasma membrane occur.
Synonyms: cytoplasmic face of Golgi trans cisterna membrane; cytoplasmic leaflet of Golgi trans cisterna membrane; cytoplasmic side of Golgi trans cisternae membrane
lumenal side of trans-Golgi cisternae membrane (GO:0160289)
Namespace: cellular_component
Definition: The leaflet of the trans-Golgi cisternae membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where the final steps of glycan processing, proteolytic modification, and cargo maturation prior to sorting at the trans-Golgi network occur.
Synonyms: lumenal face of trans-Golgi cisternae membrane; lumenal leaflet of trans-Golgi cisternae membrane; lumenal side of Golgi trans cisternae membrane
2-oxoglutarate-dependent tRNA 5-methylcytidine formyltransferase activity (GO:0160290)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 2-oxoglutarate + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 succinate + 2 CO2 + H2O.
phosphatidylinositol-4-phosphate-cholesterol exchange activity (GO:0160291)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out). This reaction results in the exchange of cholesterol for phosphatidylinositol-4-phosphate (PI(4)P) between membranes.
sodium-translocating NADH:quinone reductase complex (GO:0160292)
Namespace: cellular_component
Definition: A bacterial protein complex consisting of six subunits, NqrABCDEF, encoded by the nqr operon, which catalyzes electron transfer from NADH to ubiquinone in the respiratory chain coupled with the transport of sodium ions from the cytoplasm to the periplasm.
Synonyms: Na(+)-translocating NADH-quinone reductase complex; Na+-NQR complex
clathrin- and caveolae-independent endocytosis (GO:0160294)
Namespace: biological_process
Definition: An endocytosis process that internalizes cargo via small, non-coated vesicles (~40-80 nm) without relying on clathrin or caveolin and can be dynamin-dependent or dynamin-independent.
mitochondrial complex I intermediate assembly complex (GO:0160295)
Namespace: cellular_component
Definition: A protein complex involved in mitochondrial respiratory chain complex I (MCI) assembly. The mitochondrial complex I intermediate assembly (MCIA) complex is an inner mitochondrial membrane complex required for the aggregation, arrangement and bonding together of the subunits of the ND2-module of MCI. In humans, the MCIA complex is formed from NDUFAF1, ACAD9, ECSIT, TMEM126B, TMEM186 and COA1.
Synonyms: MCIA complex; mitochondrial CI assembly complex
IRES-mediated translation initiation factor activity (GO:0160297)
Namespace: molecular_function
Definition: A translation initiation factor activity that enables interaction with internal ribosome entry sites (IRESs) located within mRNA, promoting ribosome recruitment and assembly at internal initiation sites and translation initiation independent of the 5' cap structure.
pyridinol guanylyltransferase activity (GO:0160298)
Namespace: molecular_function
Definition: Catalysis of the reaction: 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol + GTP + H+ = guanylylpyridinol + diphosphate.
guanylylpyridinol adenylase activity (GO:0160301)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanylylpyridinol + ATP + H+ = guanylylpyridinol-AMP + diphosphate.
6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity (GO:0160302)
Namespace: molecular_function
Definition: Catalysis of the reaction: 6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol + S-adenosyl-L-methionine = 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol + S-adenosyl-L-homocysteine + H+.
protein secretion by the type IX secretion system (GO:0160303)
Namespace: biological_process
Definition: The process by which proteins are transported from the periplasmic space across the outer membrane of Bacteroidota bacteria via the type IX secretion system (T9SS).
Synonyms: Por secretion system; PorSS; T9SS
4-vinylphenol methyltransferase activity (GO:0160304)
Namespace: molecular_function
Definition: Catalysis of the reaction: 4-vinylphenol + S-adenosyl-L-methionine = 4-vinylanisole + S-adenosyl-L-homocysteine + H+.
4-vinylanisole biosynthetic process (GO:0160305)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of 4-vinylanisole. 4-vinylanisole derived from food plant phenylalanin is the aggregation pheromone specifically released by gregarious migratory locusts.
swarm social behavior (GO:0160306)
Namespace: biological_process
Definition: A social behavior in which multiple individuals of the same animal species coordinate their movement in close spatial proximity, forming a dynamic aggregation typically characterized by collective motion, cohesion, and mutual responsiveness among members of the group.
Synonyms: swarming behavior
protein biosynthetic process (GO:0160307)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of protein.
Synonyms: protein biosynthesis; protein synthesis
succinate dehydrogenase (FAD) activity (GO:0160308)
Namespace: molecular_function
Definition: Catalysis of the reaction: FAD + succinate + H+ = fumarate + FADH2.
commander complex (GO:0160309)
Namespace: cellular_component
Definition: A protein complex that promotes the recycling of internalized transmembrane proteins from endosomes back to the plasma membrane. The commander complex consists of the CCC (COMMD/CCDC22/CCDC93) subcomplex and the retriever subcomplex. In human, the CCC subcomplex consists of COMMD1, COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, CCDC22 and CCDC93 and the retriever complex consists of VPS26C, VPS29 and VPS35L.