LiteFold/GO huggingface dataset:
6-phosphofructokinase complex (GO:0005945)
Namespace: cellular_component
Definition: A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) (GO:0005946)
Namespace: cellular_component
Definition: A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.
Synonyms: trehalose-6-phosphate synthase complex; trehalose-6-phosphate synthase/phosphatase; UDP-glucose-glucosephosphate glucosyltransferase complex
Comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'.
obsolete mitochondrial alpha-ketoglutarate dehydrogenase complex (GO:0005947)
Namespace: cellular_component
Definition: OBSOLETE. Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.
Synonyms: 2-oxoglutarate dehydrogenase complex
Comment: The reason for obsoletion is that this term is equivalent to mitochondrial oxoglutarate dehydrogenase complex.
acetolactate synthase complex (GO:0005948)
Namespace: cellular_component
Definition: A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.
Synonyms: acetohydroxyacid synthase complex
Comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
obsolete aminoadipate-semialdehyde dehydrogenase complex (GO:0005949)
Namespace: cellular_component
Definition: OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde.
Synonyms: aminoadipate-semialdehyde dehydrogenase complex
Comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products.
anthranilate synthase complex (GO:0005950)
Namespace: cellular_component
Definition: A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine.
carbamoyl-phosphate synthase complex (GO:0005951)
Namespace: cellular_component
Definition: A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
Synonyms: arginine-specific carbamoyl phosphate synthetase complex; carbamoyl phosphate synthase complex; carbamoyl-phosphate synthase arginine-specific complex
Comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
cAMP-dependent protein kinase complex (GO:0005952)
Namespace: cellular_component
Definition: An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
Synonyms: 3',5' cAMP-dependent protein kinase complex; 3',5'-cAMP-dependent protein kinase complex; adenosine 3',5'-cyclophosphate-dependent protein kinase complex; cyclic AMP-dependent protein kinase complex; PKA
CAAX-protein geranylgeranyltransferase complex (GO:0005953)
Namespace: cellular_component
Definition: A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.
calcium- and calmodulin-dependent protein kinase complex (GO:0005954)
Namespace: cellular_component
Definition: An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
Synonyms: calcium/calmodulin-dependent protein kinase complex; CAMK2; CaMKII
calcineurin complex (GO:0005955)
Namespace: cellular_component
Definition: A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.
Synonyms: calcium-dependent protein serine/threonine phosphatase complex; protein phosphatase type 2B complex
protein kinase CK2 complex (GO:0005956)
Namespace: cellular_component
Definition: A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.
Synonyms: casein kinase II complex
Comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex.
obsolete debranching enzyme (GO:0005957)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: debranching enzyme
Comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex.
DNA-dependent protein kinase-DNA ligase 4 complex (GO:0005958)
Namespace: cellular_component
Definition: A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.
glycine cleavage complex (GO:0005960)
Namespace: cellular_component
Definition: A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.
Synonyms: glycine cleavage system; glycine decarboxylase complex; glycine dehydrogenase (decarboxylating) complex; glycine dehydrogenase complex (decarboxylating); glycine synthase complex
obsolete mitochondrial isocitrate dehydrogenase complex (NAD+) (GO:0005962)
Namespace: cellular_component
Definition: OBSOLETE. Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity.
Comment: The reason for obsoletion is that this term is unnecessarily taxon-specific.
magnesium-dependent protein serine/threonine phosphatase complex (GO:0005963)
Namespace: cellular_component
Definition: An intracellular enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase.
phosphorylase kinase complex (GO:0005964)
Namespace: cellular_component
Definition: An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.
protein farnesyltransferase complex (GO:0005965)
Namespace: cellular_component
Definition: A protein complex that possesses protein farnesyltransferase activity.
obsolete cyclic-nucleotide phosphodiesterase complex (GO:0005966)
Namespace: cellular_component
Definition: OBSOLETE. An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide.
Synonyms: photoreceptor cyclic-nucleotide phosphodiesterase complex
Comment: This term was obsoleted because it described a homomer.
obsolete mitochondrial pyruvate dehydrogenase complex (GO:0005967)
Namespace: cellular_component
Definition: OBSOLETE. A mitochondrial complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
Synonyms: pyruvate dehydrogenase complex (lipoamide)
Comment: This term is unnecessarily taxon-specific.
Rab-protein geranylgeranyltransferase complex (GO:0005968)
Namespace: cellular_component
Definition: An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein).
Synonyms: GGTase-II complex; Rab geranylgeranyltransferase complex; RabGGTase complex
ribonucleoside-diphosphate reductase complex (GO:0005971)
Namespace: cellular_component
Definition: An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.
Synonyms: ribonucleotide reductase complex; RNR complex
obsolete fibrinogen alpha chain (GO:0005972)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: fibrinogen alpha chain
Comment: This term was made obsolete because it represents a single gene product and not a complex.
obsolete fibrinogen beta chain (GO:0005973)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: fibrinogen beta chain
Comment: This term was made obsolete because it represents a single gene product and not a complex.
obsolete fibrinogen gamma chain (GO:0005974)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: fibrinogen gamma chain
Comment: This term was made obsolete because it represents a single gene product and not a complex.
carbohydrate metabolic process (GO:0005975)
Namespace: biological_process
Definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
Synonyms: carbohydrate metabolism
polysaccharide metabolic process (GO:0005976)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
Synonyms: glycan metabolic process; glycan metabolism; multicellular organismal polysaccharide metabolic process; polysaccharide metabolism
glycogen metabolic process (GO:0005977)
Namespace: biological_process
Definition: The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
Synonyms: glycogen metabolism
glycogen biosynthetic process (GO:0005978)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
Synonyms: glycogen anabolism; glycogen biosynthesis; glycogen formation; glycogen synthesis
regulation of glycogen biosynthetic process (GO:0005979)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
Synonyms: regulation of glycogen anabolism; regulation of glycogen biosynthesis; regulation of glycogen formation; regulation of glycogen synthesis
glycogen catabolic process (GO:0005980)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
Synonyms: glycogen breakdown; glycogen catabolism; glycogen degradation; glycogenolysis
regulation of glycogen catabolic process (GO:0005981)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.
Synonyms: regulation of glycogen breakdown; regulation of glycogen catabolism; regulation of glycogen degradation; regulation of glycogenolysis
starch metabolic process (GO:0005982)
Namespace: biological_process
Definition: The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.
Synonyms: starch metabolism
starch catabolic process (GO:0005983)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants.
Synonyms: starch breakdown; starch catabolism; starch degradation
disaccharide metabolic process (GO:0005984)
Namespace: biological_process
Definition: The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units.
Synonyms: disaccharide metabolism
sucrose metabolic process (GO:0005985)
Namespace: biological_process
Definition: The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.
Synonyms: sucrose metabolism
sucrose biosynthetic process (GO:0005986)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.
Synonyms: sucrose anabolism; sucrose biosynthesis; sucrose formation; sucrose synthesis
sucrose catabolic process (GO:0005987)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside.
Synonyms: sucrose breakdown; sucrose catabolism; sucrose degradation
lactose metabolic process (GO:0005988)
Namespace: biological_process
Definition: The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose.
Synonyms: lactose metabolism
lactose biosynthetic process (GO:0005989)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose.
Synonyms: lactose anabolism; lactose biosynthesis; lactose formation; lactose synthesis
lactose catabolic process (GO:0005990)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose.
Synonyms: lactose breakdown; lactose catabolism; lactose degradation
trehalose metabolic process (GO:0005991)
Namespace: biological_process
Definition: The chemical reactions and pathways involving trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose.
Synonyms: mycose metabolic process; mycose metabolism; mykose metabolic process; mykose metabolism; trehalose metabolism
trehalose catabolic process (GO:0005993)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose.
Synonyms: mycose catabolic process; mycose catabolism; mykose catabolic process; mykose catabolism; trehalose breakdown; trehalose catabolism; trehalose degradation
obsolete melibiose metabolic process (GO:0005994)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose.
Synonyms: melibiose metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
melibiose catabolic process (GO:0005995)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose.
Synonyms: melibiose breakdown; melibiose catabolism; melibiose degradation
xylulose metabolic process (GO:0005997)
Namespace: biological_process
Definition: The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose.
Synonyms: xylulose metabolism
xylulose catabolic process (GO:0005998)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose.
Synonyms: xylulose breakdown; xylulose catabolism; xylulose degradation
xylulose biosynthetic process (GO:0005999)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose.
Synonyms: xylulose anabolism; xylulose biosynthesis; xylulose formation; xylulose synthesis
fructose metabolic process (GO:0006000)
Namespace: biological_process
Definition: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
Synonyms: fructose metabolism
fructose catabolic process (GO:0006001)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose.
Synonyms: fructose breakdown; fructose catabolism; fructose degradation
fructose 6-phosphate metabolic process (GO:0006002)
Namespace: biological_process
Definition: The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
Synonyms: fructose 6-phosphate metabolism
fructose 2,6-bisphosphate metabolic process (GO:0006003)
Namespace: biological_process
Definition: The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
Synonyms: fructose 2,6-bisphosphate metabolism
fucose metabolic process (GO:0006004)
Namespace: biological_process
Definition: The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose.
Synonyms: fucose metabolism
L-fucose biosynthetic process (GO:0006005)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose).
Synonyms: L-fucose anabolism; L-fucose biosynthesis; L-fucose formation; L-fucose synthesis
glucose metabolic process (GO:0006006)
Namespace: biological_process
Definition: The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
Synonyms: cellular glucose metabolic process; glucose metabolism
glucose catabolic process (GO:0006007)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.
Synonyms: glucose breakdown; glucose catabolism; glucose degradation
glucose 1-phosphate phosphorylation (GO:0006009)
Namespace: biological_process
Definition: The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate.
UDP-alpha-D-glucose metabolic process (GO:0006011)
Namespace: biological_process
Definition: The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate.
Synonyms: UDP-glucose metabolism
galactose metabolic process (GO:0006012)
Namespace: biological_process
Definition: The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
Synonyms: galactose metabolism
mannose metabolic process (GO:0006013)
Namespace: biological_process
Definition: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
Synonyms: mannose metabolism
D-ribose metabolic process (GO:0006014)
Namespace: biological_process
Definition: The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.
Synonyms: D-ribose metabolism
5-phosphoribose 1-diphosphate biosynthetic process (GO:0006015)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
Synonyms: 5-phosphoribose 1-diphosphate anabolism; 5-phosphoribose 1-diphosphate biosynthesis; 5-phosphoribose 1-diphosphate formation; 5-phosphoribose 1-diphosphate synthesis; 5-phosphoribosyl-1-pyrophosphate biosynthesis; 5-phosphoribosyl-1-pyrophosphate biosynthetic process; PRPP biosynthetic process
2-deoxyribose 1-phosphate biosynthetic process (GO:0006016)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose.
Synonyms: 2-deoxyribose 1-phosphate anabolism; 2-deoxyribose 1-phosphate biosynthesis; 2-deoxyribose 1-phosphate formation; 2-deoxyribose 1-phosphate synthesis
2-deoxyribose 1-phosphate catabolic process (GO:0006018)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose.
Synonyms: 2-deoxyribose 1-phosphate breakdown; 2-deoxyribose 1-phosphate catabolism; 2-deoxyribose 1-phosphate degradation; deoxyribose 1-phosphate catabolic process
obsolete deoxyribose 5-phosphate phosphorylation (GO:0006019)
Namespace: biological_process
Definition: OBSOLETE. The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate.
Comment: This term was obsoleted because it is an unnecessary grouping term.
inositol biosynthetic process (GO:0006021)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
Synonyms: inositol anabolism; inositol biosynthesis; inositol formation; inositol synthesis; myo-inositol biosynthesis; myo-inositol biosynthetic process; vitamin Bh biosynthesis; vitamin Bh biosynthetic process
aminoglycan metabolic process (GO:0006022)
Namespace: biological_process
Definition: The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.
Synonyms: aminoglycan metabolism