LiteFold/GO huggingface dataset:
cellular detoxification of copper ion (GO:1990880)
Namespace: biological_process
Definition: Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration.
obsolete negative regulation of transcription from RNA polymerase II promoter in response to DNA damage (GO:1990881)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage.
Synonyms: down regulation of transcription from RNA polymerase II promoter in response to DNA damage; down-regulation of transcription from RNA polymerase II promoter in response to DNA damage; downregulation of transcription from RNA polymerase II promoter in response to DNA damage; inhibition of transcription from RNA polymerase II promoter in response to DNA damage
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
rRNA acetylation (GO:1990882)
Namespace: biological_process
Definition: The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.
18S rRNA cytidine N-acetyltransferase activity (GO:1990883)
Namespace: molecular_function
Definition: Catalysis of the reaction: a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H+.
RNA acetylation (GO:1990884)
Namespace: biological_process
Definition: The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule.
obsolete 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity (GO:1990887)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+.
Comment: This term was obsoleted because it represents the same reaction as 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity ; GO:0010420.
2-polyprenyl-6-hydroxyphenol O-methyltransferase activity (GO:1990888)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+.
histone H4K20me3 reader activity (GO:1990889)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H4 trimethylated at lysine 20.
Synonyms: H4K20me3 modified histone binding
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
netrin receptor binding (GO:1990890)
Namespace: molecular_function
Definition: Binding to a netrin receptor.
mitotic sister chromatid arm separation (GO:1990891)
Namespace: biological_process
Definition: The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis.
mitotic chromosome arm condensation (GO:1990892)
Namespace: biological_process
Definition: The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
mitotic chromosome centromere condensation (GO:1990893)
Namespace: biological_process
Definition: The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis.
Synonyms: mitotic chromosome condensation at kinetochore
obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter (GO:1990894)
Namespace: biological_process
Definition: OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion.
Comment: This term was obsoleted during the TG review process. It should have been created using a template.
regulation of protein localization to cell cortex of cell tip (GO:1990895)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip.
protein localization to cell cortex of cell tip (GO:1990896)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip.
obsolete CTDK-1 complex (GO:1990897)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex that phosphorylates serine 2 residues in the CTD domain of productively elongating large subunits of DNA-directed RNA polymerase II, holoenzyme. In S. cerevisiae this complex consists of CTK1/CTK2/CTK3, in S. pombe Lsk1/Lsc1/Lsg1. Human CTK1 homologs include CDK12/13.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete meiotic DNA double-strand break clipping (GO:1990898)
Namespace: biological_process
Definition: OBSOLETE. The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP).
Comment: This term was obsoleted because it represents a molecular function.
obsolete meiotic DNA double-strand break resectioning (GO:1990899)
Namespace: biological_process
Definition: OBSOLETE. The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends.
Comment: This term was obsoleted because it represents a molecular function.
ciliary pocket collar (GO:1990900)
Namespace: cellular_component
Definition: A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma.
Synonyms: cilium pocket collar; flagellar collar; flagellar pocket collar; flagellar pore; flagellum pocket collar; FPC
Comment: Note that a 'flagellar collar' is described in Choanoflagellates, but this is different from the ciliary pocket collar found e.g. in Giardia; in Choanoflagellates, a single apical flagellum is surrounded by a collar of 30-40 microvilli.
old cell pole (GO:1990901)
Namespace: cellular_component
Definition: The cell pole distal from the most recent cell division.
new cell pole (GO:1990902)
Namespace: cellular_component
Definition: The cell pole proximal to the most recent cell division.
ribonucleoprotein complex (GO:1990904)
Namespace: cellular_component
Definition: A macromolecular complex that contains both RNA and protein molecules.
Synonyms: extracellular ribonucleoprotein complex; intracellular ribonucleoprotein complex; protein-RNA complex; RNA-protein complex; RNP
accessory outer segment (GO:1990906)
Namespace: cellular_component
Definition: A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors.
beta-catenin-TCF complex (GO:1990907)
Namespace: cellular_component
Definition: A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.
Synonyms: beta-catenin/LEF complex; beta-catenin/lymphoid enhancer binding factor complex; beta-catenin/T-cell factor complex
obsolete Lys63-specific zinc metallopeptidase deubiquitinase activity (GO:1990908)
Namespace: molecular_function
Definition: OBSOLETE. Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein by a mechanism where zinc acts as the nucleophile.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
Wnt signalosome (GO:1990909)
Namespace: cellular_component
Definition: A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
Synonyms: LRP5/6 signalosome; LRP6 signalosome; Wnt signalosome complex; Wnt-LRP5/6 signalosome
Comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
response to hypobaric hypoxia (GO:1990910)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).
obsolete response to microwave radiation (GO:1990912)
Namespace: biological_process
Definition: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microwave radiation stimulus.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
sperm head plasma membrane (GO:1990913)
Namespace: cellular_component
Definition: The plasma membrane that is part of the head section of a sperm cell.
obsolete integral component of periplasmic side of plasma membrane (GO:1990914)
Namespace: cellular_component
Definition: OBSOLETE. The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
structural constituent of ascospore wall (GO:1990915)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of an ascospore wall.
Isp3 layer of spore wall (GO:1990916)
Namespace: cellular_component
Definition: The outermost layers of the spore wall, as described in Schizosaccharomyces pombe.
double-strand break repair involved in meiotic recombination (GO:1990918)
Namespace: biological_process
Definition: The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination.
proteasome-nuclear membrane anchor activity (GO:1990919)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome.
Synonyms: nuclear membrane proteasome adaptor; nuclear membrane proteasome anchor; nuclear membrane proteasome tether; nuclear membrane proteasome tether activity; nuclear membrane-proteasome anchor activity; nuclear membrane-proteasome tether activity; tethering factor for nuclear proteasome
obsolete proteasome localization to nuclear periphery (GO:1990921)
Namespace: biological_process
Definition: OBSOLETE. A process in which a proteasome is transported to, or maintained in, a location within the nuclear periphery.
Synonyms: proteasome localisation to nuclear periphery
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
hepatic stellate cell proliferation (GO:1990922)
Namespace: biological_process
Definition: The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver.
Synonyms: hepatic perisinusoidal cell proliferation; Ito cell proliferation; perisinusoidal cell proliferation
PET complex (GO:1990923)
Namespace: cellular_component
Definition: A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs.
obsolete amphisome membrane (GO:1990924)
Namespace: cellular_component
Definition: OBSOLETE. The lipid bilayer surrounding the amphisome and separating its contents from the cell cytoplasm.
Synonyms: amphisomal membrane
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
short-term synaptic potentiation (GO:1990926)
Namespace: biological_process
Definition: The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds.
Synonyms: synaptic facilitation
Comment: The mechanism of short term potentiation is thought to be either increased influx of calcium into the presynapse (Zucker and Regeh, 2002 PMID:11826273) increased sensitivity to calcium (Jackman et al., 2016 PMID:26738595) or both.
calcium ion regulated lysosome exocytosis (GO:1990927)
Namespace: biological_process
Definition: The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
response to amino acid starvation (GO:1990928)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
sulfoquinovosidase activity (GO:1990929)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O = 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol.
mRNA N1-methyladenosine dioxygenase activity (GO:1990930)
Namespace: molecular_function
Definition: Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde.
Synonyms: RNA N(1)-methyladenosine dioxygenase activity; RNA N1-methyladenosine dioxygenase activity
mRNA N6-methyladenosine dioxygenase activity (GO:1990931)
Namespace: molecular_function
Definition: Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
Synonyms: mRNA N(6)-methyladenine demethylase; mRNA N(6)-methyladenosine dioxygenase activity; RNA N6-methyladenosine dioxygenase activity
5.8S rRNA binding (GO:1990932)
Namespace: molecular_function
Definition: Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA.
microtubule cytoskeleton attachment to nuclear envelope (GO:1990933)
Namespace: biological_process
Definition: A process in which the microtubule cytoskeleton is attached to the nuclear envelope.
nucleolus-like body (GO:1990934)
Namespace: cellular_component
Definition: A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles.
Synonyms: compact nucleolus; NLB
splicing factor binding (GO:1990935)
Namespace: molecular_function
Definition: Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.
vascular associated smooth muscle cell dedifferentiation (GO:1990936)
Namespace: biological_process
Definition: The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Synonyms: vascular smooth muscle cell dedifferentiation
obsolete xylan acetylation (GO:1990937)
Namespace: biological_process
Definition: OBSOLETE. The addition of one or more acetyl groups to a xylan molecule.
Comment: The reason for obsoletion is that the term represents a molecular function.
peptidyl-aspartic acid autophosphorylation (GO:1990938)
Namespace: biological_process
Definition: The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein.
Synonyms: aspartyl autophosphorylation; peptidyl-aspartate autophosphorylation
obsolete microtubule sliding involved in mitotic spindle elongation (GO:1990940)
Namespace: biological_process
Definition: OBSOLETE. The movement of one microtubule along another microtubule involved in mitotic spindle elongation.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
mitotic spindle kinetochore microtubule (GO:1990941)
Namespace: cellular_component
Definition: Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation.
obsolete mating type region replication fork barrier binding (GO:1990943)
Namespace: molecular_function
Definition: OBSOLETE. Binding to the replication fork barrier found in the mating type region of fission yeast.
Synonyms: RTS1 barrier binding; RTS1 element binding
Comment: This term was obsoleted because it represents a precomposed term.
exit from meiosis (GO:1990947)
Namespace: biological_process
Definition: Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half.
Synonyms: meiotic exit
metaphase/anaphase transition of meiosis I (GO:1990949)
Namespace: biological_process
Definition: The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I.
Synonyms: first meiotic metaphase/anaphase transition; meiosis I metaphase/anaphase transition
metaphase/anaphase transition of meiosis II (GO:1990950)
Namespace: biological_process
Definition: The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II.
Synonyms: meiosis II metaphase/anaphase transition; second meiotic metaphase/anaphase transition
obsolete manchette assembly (GO:1990951)
Namespace: biological_process
Definition: OBSOLETE. The assembly and organization of the manchette, a tubular array of microtubules, possibly also containing actin filaments, that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete manchette disassembly (GO:1990952)
Namespace: biological_process
Definition: OBSOLETE. A cellular process that results in the breakdown of a manchette.
Synonyms: manchette clearance
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
intramanchette transport (GO:1990953)
Namespace: biological_process
Definition: The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments.
Synonyms: IMT
G-rich single-stranded DNA binding (GO:1990955)
Namespace: molecular_function
Definition: Binding to G-rich, single-stranded DNA.
fibroblast chemotaxis (GO:1990956)
Namespace: biological_process
Definition: The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
NPHP complex (GO:1990957)
Namespace: cellular_component
Definition: A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways.
Synonyms: NPHP module
Comment: Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme.
obsolete response to thyrotropin-releasing hormone (GO:1990958)
Namespace: biological_process
Definition: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.
Synonyms: response to TRH
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
eosinophil homeostasis (GO:1990959)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Synonyms: eosinocyte homeostasis; eosinophilic granulocyte homeostasis; eosinophilic leucocyte homeostasis; eosinophilic leukocyte homeostasis
basophil homeostasis (GO:1990960)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Synonyms: basophilic leucocyte homeostasis
xenobiotic detoxification by transmembrane export across the plasma membrane (GO:1990961)
Namespace: biological_process
Definition: A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
Synonyms: drug transmembrane export
xenobiotic transport across blood-brain barrier (GO:1990962)
Namespace: biological_process
Definition: The directed movement of a xenobiotic through the blood-brain barrier.
Synonyms: drug transport across blood-brain barrier
establishment of blood-retinal barrier (GO:1990963)
Namespace: biological_process
Definition: Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type.
Synonyms: establishment of blood-retina barrier; establishment of BRB
actin cytoskeleton-regulatory complex (GO:1990964)
Namespace: cellular_component
Definition: A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat.
Comment: An example of this is Pan1 in Saccharomyces cerevisiae (UniProt ID P32521) in PMID:10594004 (inferred from direct assay).
cytosylglucuronate decarboxylase activity (GO:1990965)
Namespace: molecular_function
Definition: Catalysis of the reaction: cytosylglucuronic acid + H+ = cytosylarabinopyranose + CO2.
Comment: This enzymatic activity was shown to be involved in the bacterial blasticidin S biosynthetic pathway.
ATP generation from poly-ADP-D-ribose (GO:1990966)
Namespace: biological_process
Definition: The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.