LiteFold/GO huggingface dataset:
vasopressin receptor binding (GO:0031893)
Namespace: molecular_function
Definition: Binding to a vasopressin receptor.
Synonyms: vasopressin receptor ligand
V1A vasopressin receptor binding (GO:0031894)
Namespace: molecular_function
Definition: Binding to a V1A vasopressin receptor.
Synonyms: V1A vasopressin receptor ligand
V2 vasopressin receptor binding (GO:0031896)
Namespace: molecular_function
Definition: Binding to a V2 vasopressin receptor.
Synonyms: V2 vasopressin receptor ligand
Tic complex (GO:0031897)
Namespace: cellular_component
Definition: The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane.
Synonyms: chloroplast inner membrane translocase complex
chromoplast envelope (GO:0031898)
Namespace: cellular_component
Definition: The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chromoplast inner membrane (GO:0031899)
Namespace: cellular_component
Definition: The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma.
chromoplast outer membrane (GO:0031900)
Namespace: cellular_component
Definition: The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope.
early endosome membrane (GO:0031901)
Namespace: cellular_component
Definition: The lipid bilayer surrounding an early endosome.
late endosome membrane (GO:0031902)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a late endosome.
endosome lumen (GO:0031904)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of an endosome.
early endosome lumen (GO:0031905)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of an early endosome.
late endosome lumen (GO:0031906)
Namespace: cellular_component
Definition: The volume enclosed by the membrane of a late endosome.
glyoxysomal lumen (GO:0031908)
Namespace: cellular_component
Definition: The volume enclosed by the membranes of a glyoxysome.
cytostome (GO:0031910)
Namespace: cellular_component
Definition: Stable, specialized structure for the ingestion of food by the cell into phagosomes.
cytoproct (GO:0031911)
Namespace: cellular_component
Definition: Stable, specialized structure for extrusion of waste by the cell into the surrounding medium.
oral apparatus (GO:0031912)
Namespace: cellular_component
Definition: Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems.
Comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals.
contractile vacuole pore (GO:0031913)
Namespace: cellular_component
Definition: Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium.
negative regulation of synaptic plasticity (GO:0031914)
Namespace: biological_process
Definition: A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
Synonyms: down regulation of synaptic plasticity; down-regulation of synaptic plasticity; downregulation of synaptic plasticity; inhibition of synaptic plasticity
positive regulation of synaptic plasticity (GO:0031915)
Namespace: biological_process
Definition: A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
Synonyms: activation of synaptic plasticity; stimulation of synaptic plasticity; up regulation of synaptic plasticity; up-regulation of synaptic plasticity; upregulation of synaptic plasticity
regulation of synaptic metaplasticity (GO:0031916)
Namespace: biological_process
Definition: A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.
negative regulation of synaptic metaplasticity (GO:0031917)
Namespace: biological_process
Definition: A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.
Synonyms: down regulation of synaptic metaplasticity; down-regulation of synaptic metaplasticity; downregulation of synaptic metaplasticity; inhibition of synaptic metaplasticity
positive regulation of synaptic metaplasticity (GO:0031918)
Namespace: biological_process
Definition: A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.
Synonyms: activation of synaptic metaplasticity; stimulation of synaptic metaplasticity; up regulation of synaptic metaplasticity; up-regulation of synaptic metaplasticity; upregulation of synaptic metaplasticity
vitamin B6 transport (GO:0031919)
Namespace: biological_process
Definition: The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
pyridoxal transport (GO:0031920)
Namespace: biological_process
Definition: The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
pyridoxal phosphate transport (GO:0031921)
Namespace: biological_process
Definition: The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.
pyridoxamine transport (GO:0031922)
Namespace: biological_process
Definition: The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
pyridoxine transport (GO:0031923)
Namespace: biological_process
Definition: The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
vitamin B6 transmembrane transporter activity (GO:0031924)
Namespace: molecular_function
Definition: Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other.
Synonyms: vitamin B6 transporter activity
pyridoxal phosphate transmembrane transporter activity (GO:0031926)
Namespace: molecular_function
Definition: Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.
pyridoxamine transmembrane transporter activity (GO:0031927)
Namespace: molecular_function
Definition: Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
pyridoxine transmembrane transporter activity (GO:0031928)
Namespace: molecular_function
Definition: Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.
Synonyms: pyridoxine transporter activity
TOR signaling (GO:0031929)
Namespace: biological_process
Definition: The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
Synonyms: target of rapamycin signaling pathway; target of rapamycin signalling pathway; TOR signal transduction; TOR signaling cascade; TOR signaling pathway; TOR signalling pathway
Comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
mitochondria-nucleus signaling pathway (GO:0031930)
Namespace: biological_process
Definition: The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function.
Synonyms: mitochondria-nucleus signal transduction; mitochondrial signaling pathway; mitochondrial signalling pathway; retrograde response
TORC1 complex (GO:0031931)
Namespace: cellular_component
Definition: A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
Synonyms: dTOR/dRaptor complex; dTORC1; mTORC1; nutrient sensitive complex; rapamycin and nutrient-sensitive TOR complex; TOR complex 1; TORC 1 complex; TORC1
TORC2 complex (GO:0031932)
Namespace: cellular_component
Definition: A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
Synonyms: mTORC2; rapamycin and nutrient-insensitive TOR complex; TOR complex 2; TORC 2 complex; TORC2
obsolete telomeric heterochromatin (GO:0031933)
Namespace: cellular_component
Definition: OBSOLETE. Heterochromatic regions of the chromosome found at the telomeres.
Synonyms: telomeric chromatin
Comment: This term was obsoleted because there is no heterochromatin at the telomere and the term had been used inconsistently.
mating-type region heterochromatin (GO:0031934)
Namespace: cellular_component
Definition: Heterochromatic regions of the chromosome found at silenced mating-type loci.
obsolete regulation of chromatin silencing (GO:0031935)
Namespace: biological_process
Definition: OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing.
Synonyms: regulation of heterochromatic silencing
Comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways.
obsolete negative regulation of chromatin silencing (GO:0031936)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing.
Synonyms: down regulation of chromatin silencing; down-regulation of chromatin silencing; downregulation of chromatin silencing; inhibition of chromatin silencing; loss of chromatin silencing; negative regulation of heterochromatic silencing
Comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways.
obsolete positive regulation of chromatin silencing (GO:0031937)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing.
Synonyms: activation of chromatin silencing; positive regulation of heterochromatic silencing; stimulation of chromatin silencing; up regulation of chromatin silencing; up-regulation of chromatin silencing; upregulation of chromatin silencing
Comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways.
obsolete negative regulation of chromatin silencing at telomere (GO:0031939)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres.
Synonyms: down regulation of chromatin silencing at telomere; down-regulation of chromatin silencing at telomere; downregulation of chromatin silencing at telomere; inhibition of chromatin silencing at telomere; negative regulation of heterochromatic silencing at telomere
Comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
obsolete positive regulation of chromatin silencing at telomere (GO:0031940)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres.
Synonyms: activation of chromatin silencing at telomere; positive regulation of heterochromatic silencing at telomere; stimulation of chromatin silencing at telomere; up regulation of chromatin silencing at telomere; up-regulation of chromatin silencing at telomere; upregulation of chromatin silencing at telomere
Comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated.
filamentous actin (GO:0031941)
Namespace: cellular_component
Definition: A two-stranded helical polymer of the protein actin.
Synonyms: F-actin
Comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'.
i-AAA complex (GO:0031942)
Namespace: cellular_component
Definition: Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases.
regulation of glucocorticoid metabolic process (GO:0031943)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.
Synonyms: regulation of glucocorticoid metabolism
obsolete negative regulation of glucocorticoid metabolic process (GO:0031944)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.
Synonyms: down regulation of glucocorticoid metabolic process; down-regulation of glucocorticoid metabolic process; downregulation of glucocorticoid metabolic process; inhibition of glucocorticoid metabolic process; negative regulation of glucocorticoid metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
obsolete positive regulation of glucocorticoid metabolic process (GO:0031945)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.
Synonyms: activation of glucocorticoid metabolic process; positive regulation of glucocorticoid metabolism; stimulation of glucocorticoid metabolic process; up regulation of glucocorticoid metabolic process; up-regulation of glucocorticoid metabolic process; upregulation of glucocorticoid metabolic process
Comment: This term was obsoleted because it is an unnecessary grouping class.
negative regulation of glucocorticoid biosynthetic process (GO:0031947)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.
Synonyms: down regulation of glucocorticoid biosynthetic process; down-regulation of glucocorticoid biosynthetic process; downregulation of glucocorticoid biosynthetic process; inhibition of glucocorticoid biosynthetic process
positive regulation of glucocorticoid biosynthetic process (GO:0031948)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.
Synonyms: activation of glucocorticoid biosynthetic process; stimulation of glucocorticoid biosynthetic process; up regulation of glucocorticoid biosynthetic process; up-regulation of glucocorticoid biosynthetic process; upregulation of glucocorticoid biosynthetic process
regulation of glucocorticoid catabolic process (GO:0031949)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.
negative regulation of glucocorticoid catabolic process (GO:0031950)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.
Synonyms: down regulation of glucocorticoid catabolic process; down-regulation of glucocorticoid catabolic process; downregulation of glucocorticoid catabolic process; inhibition of glucocorticoid catabolic process
positive regulation of glucocorticoid catabolic process (GO:0031951)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.
Synonyms: activation of glucocorticoid catabolic process; stimulation of glucocorticoid catabolic process; up regulation of glucocorticoid catabolic process; up-regulation of glucocorticoid catabolic process; upregulation of glucocorticoid catabolic process
regulation of protein autophosphorylation (GO:0031952)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.
Synonyms: regulation of protein amino acid autophosphorylation
negative regulation of protein autophosphorylation (GO:0031953)
Namespace: biological_process
Definition: Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
Synonyms: down regulation of protein amino acid autophosphorylation; down-regulation of protein amino acid autophosphorylation; downregulation of protein amino acid autophosphorylation; inhibition of protein amino acid autophosphorylation; negative regulation of protein amino acid autophosphorylation
short-chain fatty acid-CoA ligase activity (GO:0031955)
Namespace: molecular_function
Definition: Catalysis of the reaction: a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.
Synonyms: short-chain fatty acid activation; short-chain fatty-acid-CoA ligase activity; short-chain-fatty-acid-CoA ligase activity
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
medium-chain fatty acid-CoA ligase activity (GO:0031956)
Namespace: molecular_function
Definition: Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
Synonyms: medium-chain fatty acid activation; medium-chain fatty-acid-CoA ligase activity; medium-chain-fatty-acid-CoA ligase activity
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
very long-chain fatty acid-CoA ligase activity (GO:0031957)
Namespace: molecular_function
Definition: Catalysis of the reaction: a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
Synonyms: very-long-chain fatty acid activation; very-long-chain fatty acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
nuclear receptor-mediated corticosteroid signaling pathway (GO:0031958)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by a corticosteroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: corticosteroid receptor signalling pathway; intracellular corticosteroid receptor signaling pathway
nuclear receptor-mediated mineralocorticoid signaling pathway (GO:0031959)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by a mineralocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: intracellular mineralocorticoid receptor signaling pathway; mineralocorticoid receptor signaling pathway; mineralocorticoid receptor signalling pathway
response to corticosteroid (GO:0031960)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.
Synonyms: response to corticosteroid stimulus
nuclear cortisol receptor binding (GO:0031961)
Namespace: molecular_function
Definition: Binding to a nuclear cortisol receptor.
Synonyms: cortisol receptor binding
nuclear mineralocorticoid receptor binding (GO:0031962)
Namespace: molecular_function
Definition: Binding to a nuclear mineralocorticoid receptor.
Synonyms: mineralocorticoid receptor binding
nuclear cortisol receptor activity (GO:0031963)
Namespace: molecular_function
Definition: A nuclear receptor activity regulated by cortisol binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.
Synonyms: cortisol receptor activity