LiteFold/GO huggingface dataset:
symbiont-mediated activation of host MAPK cascade (GO:0141071)
Namespace: biological_process
Definition: A process in which a symbiont subverts a MAPK signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: activation by symbiont of host MAPK signal transduction pathway; induction by symbiont of host MAP kinase signal transduction pathway; induction of host MAPK kinase signaling pathway; stimulation by symbiont of host MAPK signal transduction pathway; symbiont-mediated activation of host MAPK signal transduction pathway
symbiont-mediated suppression of host tumor necrosis factor-mediated signaling pathway (GO:0141072)
Namespace: biological_process
Definition: A process in which a virus interferes with, inhibits or disrupts a tumor necrosis factor-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption of host TNF-mediated signaling pathway; disruption of host TNFR-mediated signaling pathway; disruption of host tumor necrosis factor receptor-mediated signaling pathway; disruption of host tumor necrosis factor-mediated signaling pathway
symbiont-mediated perturbation of host opsonization (GO:0141073)
Namespace: biological_process
Definition: A process in which a symbiont alters or subverts opsonization by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption by symbiont of host opsonization
obsolete suppression of host JAK-STAT cascade (GO:0141075)
Namespace: biological_process
Definition: OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption of host JAK-STAT cascade; down-regulation of host JAK-STAT cascade; downregulation of host JAK-STAT cascade; inhibition of host JAK-STAT cascade; negative regulation of host JAK-STAT cascade; suppression of host JAK-STAT cascade; symbiont-mediated suppression of host JAK-STAT cascade
Comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host JAK-STAT cascade ; GO:0039514.
obsolete suppression of host TRAF-mediated signal transduction (GO:0141076)
Namespace: biological_process
Definition: OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption of host TRAF-mediated signal transduction; inhibition of host TRAF-mediated signal transduction; inhibition of host TRAFs; negative regulation of host TRAF-mediated signal transduction; suppression of host TRAF activity; suppression of host TRAF-mediated signal transduction; suppression of host tumor necrosis factor receptor-associated factor signaling; symbiont-mediated suppression of host TRAF-mediated signal transduction
Comment: This term was obsoleted because it was redundant with symbiont-mediated suppression of host TRAF-mediated signal transduction ; GO:0039527.
obsolete suppression of host interferon-mediated signaling pathway (GO:0141077)
Namespace: biological_process
Definition: OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts an interferon-mediated signaling in the host organism.
Synonyms: inhibition of host interferon signaling pathway; negative regulation of host interferon-mediated signaling pathway; suppression of host IFN-mediated signaling pathway; suppression of host interferon-mediated signaling pathway; symbiont-mediated of host interferon-mediated signaling pathway
Comment: This term was obsoleted because it represents the same concept as suppression of host interferon-mediated signaling pathway ; GO:0140886.
obsolete symbiont-mediated suppression of host RIG-I signaling pathway (GO:0141078)
Namespace: biological_process
Definition: OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a RIG-I signaling pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption of host RIG-1 signaling pathway; disruption of host RIG-I signaling pathway
Comment: This term was obsoleted because it was created by mistake; it represents the same process as symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity ; GO:0039540.
symbiont-mediated activation of host inflammasome-mediated signal transduction (GO:0141079)
Namespace: biological_process
Definition: A process in which a symbiont subverts an inflammasome-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: perturbation of host inflammasome-mediated signal transduction
symbiont-mediated activation of host interferon signaling pathway (GO:0141080)
Namespace: biological_process
Definition: A process in which a symbiont subverts an interferon-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation.
symbiont-mediated suppression of host inflammasome-mediated signal transduction (GO:0141081)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or stops an inflammasome-mediated signal transduction pathway in the host organism by interfering with its normal execution. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: perturbation of host inflammasome-mediated signal transduction
symbiont-mediated detoxification of host-generated reactive oxygen species (GO:0141082)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts the host reactive oxygen species (ROS)-mediated innate immune response by directly degrading host ROS. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host reactive oxygen species generation (GO:0141083)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts the host signal transduction pathways leading to the production of reactive oxygen species as part of the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: inhibition by organism of defense-related host active oxygen species production
inflammasome-mediated signaling pathway (GO:0141084)
Namespace: biological_process
Definition: An intracellular signal transduction pathway that starts with a ligand binding to a pattern recognition receptor (PRR), assembly of the inflammasome complex, leading to the activation of CASP1 and inducing an inflammatory response. In some cases, inflammasome-mediated signal transduction can lead to programmed cell death, such as pyroptosis.
Synonyms: inflammasome-mediated signal transduction
regulation of inflammasome-mediated signaling pathway (GO:0141085)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of an inflammasome-mediated signaling pathway.
Synonyms: regulation of inflammasome-mediated signal transduction
negative regulation of inflammasome-mediated signaling pathway (GO:0141086)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of an inflammasome-mediated signaling pathway.
Synonyms: negative regulation of inflammasome-mediated signal transduction
positive regulation of inflammasome-mediated signaling pathway (GO:0141087)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of an inflammasome-mediated signaling pathway.
Synonyms: positive regulation of inflammasome-mediated signal transduction
obsolete symbiont-mediated activation of host autophagy (GO:0141088)
Namespace: biological_process
Definition: OBSOLETE. A process in which a symbiont initiates, promotes, or enhances the activation of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: induction of host autophagy; positive regulation by symbiont of host autophagy
Comment: This term was obsoleted because it represents the same process as symbiont-mediated activation of host autophagy ; GO:0039520.
glucose sensor activity (GO:0141089)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose.
Synonyms: glucose sensing activity
protein serine pyrophosphorylase activity (GO:0141090)
Namespace: molecular_function
Definition: Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate.
Synonyms: protein serine pyrophosphatase activity
transforming growth factor beta receptor superfamily signaling pathway (GO:0141091)
Namespace: biological_process
Definition: The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: TGF-beta receptor superfamily signaling pathway; TGF-beta receptor superfamily signalling pathway; TGFbeta receptor superfamily signaling pathway; TGFbeta receptor superfamily signalling pathway; transforming growth factor beta receptor superfamily signalling pathway
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity (GO:0141093)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine.
DNA loop anchor binding (GO:0141094)
Namespace: molecular_function
Definition: Binding to a DNA loop anchor, a region of chromosome that defines the ends of a DNA loop where two parts of same DNA strand are held in close physical proximity. For example, in animals, the anchors of DNA loops are convergently oriented CTCF binding sites during interphase.
obsolete retrotransposon silencing by DNA methylation-dependent heterochromatin formation (GO:0141095)
Namespace: biological_process
Definition: OBSOLETE. A retrotransposon silencing mechanism in which a methylated cytosine residues in the genome promote heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
Comment: This term was obsoleted because it represent the same pathway as retrotransposon silencing by siRNA-directed DNA methylation ; GO:0141010.
ligand-modulated transcription repressor activity (GO:0141096)
Namespace: molecular_function
Definition: A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets.
Synonyms: ligand-activated transcription repressor activity
ligand-modulated transcription activator activity (GO:0141097)
Namespace: molecular_function
Definition: A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets.
Synonyms: ligand-activated transcription activator activity
tRNA (cytidine(34)-2'-O-ribose)-methyltransferase activity (GO:0141098)
Namespace: molecular_function
Definition: Catalysis of the reaction: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H+ + S-adenosyl-L-homocysteine.
Synonyms: tRNA (cytidine 34-2'-O)-methyltransferase activity; tRNA (cytidine(34)-2'-O)-methyltransferase activity
tRNA (5-carboxymethylaminomethyluridine(34)-2'-O-ribose)-methyltransferase activity (GO:0141102)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-carboxymethylaminomethyluridine34 in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu) + H+ + S-adenosyl-L-homocysteine.
Synonyms: tRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity; tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase activity
symbiont-mediated activation of host G protein-coupled receptor signal transduction (GO:0141104)
Namespace: biological_process
Definition: A process in which a symbiont initiates, promotes, or enhances a G protein-coupled receptor signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
obsolete suppression of host toll-like receptor signal transduction (GO:0141105)
Namespace: biological_process
Definition: OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a toll-like receptor signaling pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated disruption of host toll-like receptor signaling pathway; symbiont-mediated suppression of host toll-like receptor signal transduction; symbiont-mediated suppression of host toll-like receptor signaling pathway
Comment: This term was obsoleted because it represents the same process as symbiont-mediated suppression of host toll-like receptor signal transduction ; GO:0039722.
tRNA methyltransferase activator activity (GO:0141106)
Namespace: molecular_function
Definition: Binds to and increases the activity of a methyltransferase.
methyltransferase regulator activity (GO:0141107)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a methyltransferase.
transporter regulator activity (GO:0141108)
Namespace: molecular_function
Definition: Binds to and modulates the activity of a transporter.
transporter activator activity (GO:0141109)
Namespace: molecular_function
Definition: Binds to and increases the activity of a transporter.
positive regulation of cGAS/STING signaling pathway (GO:0141111)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of of cGAS/STING signaling pathway.
broken chromosome clustering (GO:0141112)
Namespace: biological_process
Definition: The process of bringing together chromosomes fragments resulting from DNA damage. Broken chromosome tethering during mitosis ensures clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss and enhancing genome integrity.
negative regulation of Wnt signaling pathway, planar cell polarity pathway (GO:0141113)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway, planar cell polarity pathway.
obsolete symbiont-mediated suppression of host complement activation (GO:0141114)
Namespace: biological_process
Definition: OBSOLETE. A process by which a symbiont inhibits or disrupts the normal execution of the activation of complement in its host.
Synonyms: suppression of complement activation by another organism
Comment: This term was obsoleted because it represents the same process as GO:0042784.
symbiont-mediated suppression of host complement activation by inactivation of complement proteins (GO:0141115)
Namespace: biological_process
Definition: A process by which a symbiont disrupts or prematurely activates host complement so that its microbial-destroying activities fail.
Synonyms: suppression of complement activation by another organism by inactivation of complement proteins
symbiont-mediated suppression of host complement activation by complement sequestering (GO:0141116)
Namespace: biological_process
Definition: A process by which a symbiont prevents host complement activation by sequestering it away from its surface.
Synonyms: suppression of complement activation by another organism by complement sequestering
symbiont-mediated suppression of host complement activation by recruitment of complement control protein (GO:0141117)
Namespace: biological_process
Definition: A process by which a symbiont prevents the activation of host complement by binding a soluble complement control protein (CCP) of the host and recruiting it to the microbe surface. The normal role of CCPs is to prevent complement activation on 'self' cellular targets. When soluble CCPs are recuited to the surface of a microbe, the complement fails to activate.
Synonyms: suppression of complement activation by another organism by recruitment of complement control protein; suppression of complement activation by another organism by recuitement of complement control protein
nitrogen-oxygen lyase activity (GO:0141122)
Namespace: molecular_function
Definition: Catalysis of the breakage of a nitrogen-oxygen bond by means other than hydrolysis and oxidation.
intracellular signaling cassette (GO:0141124)
Namespace: biological_process
Definition: An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways.
Synonyms: intracellular signaling cascade; intracellular signaling module
tRNA-queuosine(34) galactosyltransferase activity (GO:0141125)
Namespace: molecular_function
Definition: Catalysis of the reaction: queuosine34 in tRNA + UDP-alpha-D-galactose = H+ + O-5''-beta-D-galactosylqueuosine34 in tRNATyr + UDP. Substrates include tRNA(Tyr) and tRNA(Asp).
Synonyms: tRNA queuosine galactosyltransferase activity; tRNA queuosine(34) galactosyltransferase activity
short-chain fatty acyl-CoA hydrolase activity (GO:0141126)
Namespace: molecular_function
Definition: Catalysis of the reaction: a short-chain fatty acyl-CoA + H2O = a short fatty acid + CoA + H+. A short-chain fatty acid has an aliphatic tail of less than 6 carbons.
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
symbiont-mediated perturbation of host Rab small GTPase signal transduction (GO:0141127)
Namespace: biological_process
Definition: A process in which a symbiont alters a Rab protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: modulation by symbiont of host Rab protein mediated signal transduction; modulation by symbiont of host Rab protein signal transduction; modulation by symbiont of host Rab protein-mediated signal transduction; modulation of host Rab protein signal transduction by symbiont; modulation of host Rab protein signaling by symbiont; modulation of host Rab protein signalling by symbiont; perturbation of host Rab protein signal transduction; symbiont-mediated perturbation of host Rab protein signal transduction
symbiont-mediated non-specific activation of host T-cells (GO:0141128)
Namespace: biological_process
Definition: A process by which a symbiont superantigen elicits a strong immune response by activating a large number of T cells in a non-specific manner. Unlike conventional antigens, which activate T cells by interacting with specific receptors on the surface of these cells, superantigens can stimulate T cells by binding to regions outside the antigen-binding site. Superantigens can activate a large proportion of T cells, leading to an exaggerated immune response. This excessive activation can result in the release of a large amount of cytokines such as tumor necrosis factor and interleukin-2. The massive cytokine release can lead to an acute toxic shock, causing symptoms such as fever and organ damage.
Synonyms: symbiont-mediated non-specific T-cell activation in host; symbiont-mediated nonspecific activation of host T-cells
symbiont-mediated suppression of host signal transduction pathway via antagonism of host cell surface receptor (GO:0141129)
Namespace: biological_process
Definition: A process by which a symbiont alters or subverts a host cell surface receptor-mediated signal transduction pathway by binding to and inhibiting the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor
symbiont-mediated inactivation of host ribosome (GO:0141130)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts translation of mRNA into protein in its host by inactivating its ribosomes.
Synonyms: symbiont-mediated host ribosome inactivation
DNA N6-methyladenine demethylase activity (GO:0141131)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-oxoglutarate + an N6-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate.
Synonyms: DNA N(6)-methyladenine demethylase activity
obsolete defense response to host (GO:0141132)
Namespace: biological_process
Definition: OBSOLETE. Reactions triggered in response to the presence of a host that act to protect or prevent damage to the symbiont.
Comment: This term was obsoleted because it represents an unnecessary grouping term.
diphthine methyl ester synthase activity (GO:0141133)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H+ + 4 S-adenosyl-L-homocysteine.
Comment: This activity is present in eukaryotes and is part of the biosynthetic pathway of diphthamide. Note that this is different from the archaeal enzyme, diphthine synthase activity ; GO:0004164 (EC:2.1.1.98), which performs only 3 methylations, producing diphthine.
symbiont-mediated activation of host signal transduction pathway via agonism of host cell surface receptor (GO:0141134)
Namespace: biological_process
Definition: A process in which a symbiont subverts a signal transduction pathway in the host organism by binding to and enhancing the activation of the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor
symbiont-mediated suppression of host chemokine signal transduction pathway (GO:0141135)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a chemokine signaling pathway, a G protein-coupled receptor signal transduction pathway activated by a chemokine. The host is defined as the larger of the organisms involved in a symbiotic interaction.
positive regulation of gene expression, epigenetic (GO:0141137)
Namespace: biological_process
Definition: An epigenetic process that increases gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA demethylation.
Synonyms: activation of gene expression, epigenetic; up regulation of gene expression, epigenetic; up-regulation of gene expression, epigenetic; upregulation of gene expression, epigenetic
symbiont-mediated disruption of host mucosa (GO:0141139)
Namespace: biological_process
Definition: The disruption of the host mucosa by a symbiont, leading to damage or temporary subversion of that tissue. The mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs.