LiteFold/GO huggingface dataset:
obsolete 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming) (GO:0140868)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 3 H+ + 15-cis-4,4'-diapophytoene + 3 FAD = 4,4'-diapolycopene + 3 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product.
Synonyms: 4,4'-diapophytoene desaturase activity
Comment: This term was obsoleted because the reaction it represents may not be physiologically relevant.
miRNA inhibitor activity via base-pairing (GO:0140869)
Namespace: molecular_function
Definition: Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs).
Synonyms: base-pairing target-directed microRNA suppressor activity; base-pairing target-directed miRNA suppressor activity; miRNA base-pairing repressor activity; miRNA binding involved in posttranscriptional gene silencing; miRNA inhibitor activity; miRNA sponge
Comment: This term is intended for regulatory non-coding RNAs that act by base-pairing with a target microRNA.
RNA polymerase inhibitor activity (GO:0140870)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of RNA polymerase.
repressor of RNA polymerase inhibitor activity (GO:0140871)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor.
paxilline biosynthetic process (GO:0140873)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels.
Synonyms: paxilline anabolism; paxilline biosynthesis; paxilline formation; paxilline synthesis
paraherquonin biosynthetic process (GO:0140874)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture.
Synonyms: paraherquonin anabolism; paraherquonin biosynthesis; paraherquonin formation; paraherquonin synthesis
andrastin A biosynthetic process (GO:0140876)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of andrastin A, a meroterpenoid that exhibits inhibitory activity against ras farnesyltransferase, suggesting that it could have promising antitumor activity.
Synonyms: andrastin A anabolism; andrastin A biosynthesis; andrastin A formation; andrastin A synthesis
mevastatin biosynthetic process (GO:0140877)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of mevastatin , also known as compactin or ML-236B, and which acts as a potent competitive inhibitor of HMG-CoA reductase.
Synonyms: mevastatin anabolism; mevastatin biosynthesis; mevastatin formation; mevastatin synthesis
griseofulvin biosynthetic process (GO:0140878)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections.
Synonyms: griseofulvin anabolism; griseofulvin biosynthesis; griseofulvin formation; griseofulvin synthesis
conidiogenone biosynthetic process (GO:0140879)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of conidiogenone , a diterpene known to induce the conidiation.
Synonyms: conidiogenone anabolism; conidiogenone biosynthesis; conidiogenone formation; conidiogenone synthesis
terrein biosynthetic process (GO:0140880)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of terrein, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities.
Synonyms: terrein anabolism; terrein biosynthesis; terrein formation; terrein synthesis
zinc export across plasma membrane (GO:0140882)
Namespace: biological_process
Definition: The directed movement of zinc ions from a cell, into the extracellular region.
Synonyms: zinc ion export from cell
symbiont-mediated activation of host reticulophagy (GO:0140883)
Namespace: biological_process
Definition: A process in which a symbiont initiates, promotes, or enhances the normal execution of host reticulophagy, leading to an increase in the frequency, rate or extent of reticulophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: activation of host reticulophagy by virus; induction by virus of host reticulophagy; positive regulation by virus of host reticulophagy
symbiont-mediated suppression of host type II interferon-mediated signaling pathway (GO:0140884)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma.
Synonyms: negative regulation by virus of host type II interferon-mediated signaling pathway; suppression by virus of host type II IFN-mediated signaling pathway; suppression by virus of host type II interferon-mediated signaling pathway; suppression by virus of host type II interferon-mediated signalling pathway
symbiont-mediated suppression of host type III interferon-mediated signaling pathway (GO:0140885)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts a type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda.
Synonyms: negative regulation by virus of host type III interferon-mediated signaling pathway; suppression by virus of host type III IFN-mediated signaling pathway; suppression by virus of host type III interferon-mediated signaling pathway; suppression by virus of host type III interferon-mediated signalling pathway
symbiont-mediated suppression of host interferon-mediated signaling pathway (GO:0140886)
Namespace: biological_process
Definition: Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism.
Synonyms: inhibition of host interferon signaling pathway by symbiont; negative regulation by virus of host interferon-mediated signaling pathway; suppression by symbiont of host IFN-mediated signaling pathway; suppression by symbiont of host interferon-mediated signalling pathway; suppression by virus of host interferon-mediated signaling pathway
positive regulation of nucleosome disassembly (GO:0140887)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
interferon-mediated signaling pathway (GO:0140888)
Namespace: biological_process
Definition: The series of molecular signals initiated by type II interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type II interferon is also known as interferon-gamma.
Synonyms: interferon signaling pathway; interferon-activated signaling pathway
H1 histone chaperone activity (GO:0140890)
Namespace: molecular_function
Definition: A histone chaperone that carries a H1 histone.
Synonyms: H1 histone carrier activity
tRNA-derived regulatory ncRNA processing (GO:0140891)
Namespace: biological_process
Definition: A process leading to the generation of a functional small regulatory non-coding RNA derived from a tRNA.
Synonyms: tRNA-derived small RNA processing
sodium,bicarbonate:chloride antiporter activity (GO:0140892)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in).
Synonyms: sodium,hydrogencarbonate:chloride antiporter activity; sodium-dependent chloride/bicarbonate exchanger activity
neutral amino acid, sodium:proton antiporter activity (GO:0140893)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + amino acid(out) + Na+(out) = H+(out) + amino acid(in) + Na+(in).
Synonyms: amino acid-coupled Na+/H+ exchanger activity
endolysosomal toll-like receptor signaling pathway (GO:0140894)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to an endolysosomal pattern recognition receptor (PRR) of the toll-like family. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
Synonyms: endolysosomal pattern recognition receptor signaling pathway
cell surface toll-like receptor signaling pathway (GO:0140895)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR) of the toll-like family.
Synonyms: cell surface TLR signaling pathway
cGAS/STING signaling pathway (GO:0140896)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.
mechanoreceptor activity (GO:0140897)
Namespace: molecular_function
Definition: Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
CENP-A eviction from euchromatin (GO:0140898)
Namespace: biological_process
Definition: A chromatin remodeling process in which CENP-A is removed from euchromatin regions to prevent neocentromere formation.
plastid gene expression (GO:0140899)
Namespace: biological_process
Definition: The process in which a plastid gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
chloride:bicarbonate antiporter activity (GO:0140900)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in).
Synonyms: bicarbonate:chloride antiporter activity; chloride:hydrogencarbonate antiporter activity
L-asparagine:sodium symporter activity (GO:0140901)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in).
Synonyms: asparagine:sodium symporter activity; sodium:asparagine symporter activity; sodium:L-asparagine symporter activity
L-glutamine:sodium symporter activity (GO:0140902)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in).
Synonyms: glutamine:sodium symporter activity; sodium:glutamine symporter activity; sodium:L-glutamine symporter activity
histone H3R26 methyltransferase activity (GO:0140903)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3.
Synonyms: histone H3R26 arginine methyltransferase activity; histone methylase activity (H3-R26 specific); histone methyltransferase activity (H3-R26 specific); histone-arginine N-methyltransferase activity (H3-R26 specific); histone-H3R26 methyltransferase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
cytoophidium organization (GO:0140904)
Namespace: biological_process
Definition: A process which results in the assembly, arrangement of constituent parts, or disassembly of a cytoophidium. Cytoophidia are mesoscale, intracellular, filamentous structures that contain metabolic enzymes.
haloperoxidase activity (GO:0140905)
Namespace: molecular_function
Definition: Catalysis of the reaction: R-CH + a halogen + H2O2 = R-C-halogen + H2O.
halogenase activity (GO:0140906)
Namespace: molecular_function
Definition: Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O.
flavin-dependent halogenase activity (GO:0140907)
Namespace: molecular_function
Definition: Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O.
kinetoplast DNA replication (GO:0140909)
Namespace: biological_process
Definition: The process of doubling of the number of maxicircles and minicircles and distribution of the progeny into two daughter networks, which are identical to the parent kinetoplast DNA network.
Synonyms: kDNA replication; kinetoplast DNA synthesis; replication of kinetoplast DNA
iRhom2/ADAM17 sheddase complex (GO:0140910)
Namespace: cellular_component
Definition: A complex consisting of ADAM17 in complex with regulatory iRhoms and FERM domain containing proteins.
pore-forming activity (GO:0140911)
Namespace: molecular_function
Definition: An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.
Synonyms: canonical holin activity; holin activity; pinholin activity; pore forming activity
membrane destabilizing activity (GO:0140912)
Namespace: molecular_function
Definition: Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release.
Synonyms: antimicrobial peptide
viral release via disruption of host peptidoglycan cell wall (GO:0140913)
Namespace: biological_process
Definition: The dissemination of mature viral particles from a host cell, caused by a virus hydrolyzing the peptidoglycan cell wall of the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.
zinc ion import into secretory vesicle (GO:0140914)
Namespace: biological_process
Definition: The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a secretory vesicle.
zinc ion import into zymogen granule (GO:0140915)
Namespace: biological_process
Definition: The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a zymogen granule.
zinc ion import into lysosome (GO:0140916)
Namespace: biological_process
Definition: The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a lysosome.
zinc ion import into mitochondrion (GO:0140917)
Namespace: biological_process
Definition: The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a mitochondrion.
centrosomal core (GO:0140918)
Namespace: cellular_component
Definition: The core region of the centrosome, a layered structure containing proteins, surrounded by the centrosomal corona. The core duplicates once per cell cycle at the G2/M transition when two outer layers form the mitotic spindle poles.
Synonyms: centrosome core
thermomorphogenesis (GO:0140919)
Namespace: biological_process
Definition: The suite of morphological and architectural changes in an organism induced by high ambient temperatures, below the heat-stress range.
regulation of thermomorphogenesis (GO:0140920)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of thermomorphogenesis.
negative regulation of thermomorphogenesis (GO:0140921)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of thermomorphogenesis.
positive regulation of thermomorphogenesis (GO:0140922)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of thermomorphogenesis.
L-kynurenine transmembrane transport (GO:0140924)
Namespace: biological_process
Definition: The directed movement of L-kynurenine across a membrane.
L-phenylalanine import across plasma membrane (GO:0140925)
Namespace: biological_process
Definition: The directed movement of L-phenylalanine from outside of a cell, across the plasma membrane and into the cytosol.
L-kynurenine transmembrane transporter activity (GO:0140926)
Namespace: molecular_function
Definition: Enables the transfer of L-kynurenine from one side of a membrane to the other.
cyclic-di-GMP transmembrane transporter activity (GO:0140927)
Namespace: molecular_function
Definition: Enables the transfer of cyclic-di-GMP from one side of a membrane to the other.
inhibition of non-skeletal tissue mineralization (GO:0140928)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue.
Synonyms: inhibition of ectopic tissue mineralization
mannose:sodium symporter activity (GO:0140929)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in).
fructose:sodium symporter activity (GO:0140930)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-fructose(out) + Na+(out) = D-fructose(in) + Na+(in).
neutral L-amino acid:sodium:chloride symporter activity (GO:0140931)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) + Cl-(out) = neutral L-amino acid(in) + Na+(in)+ Cl-(in).
Synonyms: neutral amino acid:sodium:chloride symporter activity
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity (GO:0140932)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate.
Synonyms: m(7)GpppN m(7)GMP phosphohydrolase activity; m(7)GpppX diphosphatase activity; m(7)GpppX pyrophosphatase activity
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity (GO:0140933)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+.
Synonyms: m(7)GpppN-mRNA hydrolase activity
histone deubiquitinase activity (GO:0140934)
Namespace: molecular_function
Definition: A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated.
Synonyms: histone deubiquitination
histone H2B conserved C-terminal lysine deubiquitinase activity (GO:0140935)
Namespace: molecular_function
Definition: A histone deubiquitinase that cleaves ubiquitin from the conserved C-terminal lysine residue of a histone H2B protein to which it is conjugated. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals.
Synonyms: histone conserved C-terminal lysine deubiquitination
histone H2B deubiquitinase activity (GO:0140936)
Namespace: molecular_function
Definition: A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated.
Synonyms: histone H2B deubiquitination
histone H4K12 deacetylase activity, hydrolytic mechanism (GO:0140937)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein.
Synonyms: histone deacetylase activity (H4-K12 specific); histone H4-K12 deacetylase activity; histone H4-K12 deacetylation; histone H4K12 deacetylase activity; histone H4K12 deacetylation
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
histone H3 methyltransferase activity (GO:0140938)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue.
Synonyms: histone H3 methylase activity; histone H3 methylation
histone H4 methyltransferase activity (GO:0140939)
Namespace: molecular_function
Definition: Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue.
Synonyms: histone H4 methylase activity; histone H4 methylation
histone H2A methyltransferase activity (GO:0140940)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue.
Synonyms: histone H2A methylase activity; histone H2A methylation
histone H4K20me methyltransferase activity (GO:0140941)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethylated lysine residue at position 20 of histone H4, producing H4K20me2.
Synonyms: histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific); histone H4-K20 dimethylation; histone H4K20 dimethylation; histone H4K20me methylase activity
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.