LiteFold/GO huggingface dataset:
antigen processing and presentation of peptide antigen (GO:0048002)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
Synonyms: antigen presentation, peptide antigen; peptide antigen processing and presentation
antigen processing and presentation of lipid antigen via MHC class Ib (GO:0048003)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
Synonyms: antigen presentation, lipid antigen; lipid antigen processing and presentation via MHC class Ib
antigen processing and presentation, endogenous lipid antigen via MHC class Ib (GO:0048006)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
Synonyms: antigen presentation, endogenous lipid antigen; endogenous lipid antigen processing and presentation via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib (GO:0048007)
Namespace: biological_process
Definition: The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
Synonyms: antigen presentation, exogenous peptide antigen; exogenous lipid antigen processing and presentation via MHC class Ib
platelet-derived growth factor receptor signaling pathway (GO:0048008)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: PDGF receptor signaling pathway; PDGF receptor signalling pathway; PDGFR signaling pathway
insulin-like growth factor receptor signaling pathway (GO:0048009)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IGF receptor signaling pathway; IGF receptor signalling pathway
vascular endothelial growth factor receptor signaling pathway (GO:0048010)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: VEGF receptor signaling pathway; VEGF receptor signalling pathway; VEGFR signaling pathway
Comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
neurotrophin TRK receptor signaling pathway (GO:0048011)
Namespace: biological_process
Definition: The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: TrkA signaling pathway; TrkB signaling pathway; TrkC signaling pathway; tropomyosin-receptor-kinase signaling
hepatocyte growth factor receptor signaling pathway (GO:0048012)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: HGF receptor signaling pathway; HGF receptor signalling pathway; Met signaling pathway
ephrin receptor signaling pathway (GO:0048013)
Namespace: biological_process
Definition: The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: Eph receptor signaling pathway; Eph receptor signalling pathway
Tie signaling pathway (GO:0048014)
Namespace: biological_process
Definition: The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: angiopoietin-Tie signaling pathway; angiopoietin/Tie signaling pathway; Tek receptor signaling; Tie receptor signaling pathway; Tie receptor signalling pathway
phosphatidylinositol-mediated signaling (GO:0048015)
Namespace: biological_process
Definition: The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
Synonyms: inositol phospholipid-mediated signaling; phosphatidylinositol-mediated signal transduction; phosphatidylinositol-mediated signalling; phosphoinositide-mediated signaling; phosphoinositide-mediated signalling
obsolete inositol phosphate-mediated signaling (GO:0048016)
Namespace: biological_process
Definition: OBSOLETE. A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
Synonyms: inositol phosphate-mediated signalling
Comment: This term was obsoleted because it was not clearly defined and represented several pathways in which the level of some inositol phosphate level was altered.
obsolete inositol lipid-mediated signaling (GO:0048017)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids.
Synonyms: inositol lipid-mediated signal transduction; inositol lipid-mediated signalling; inositol phospholipid-mediated signaling
Comment: This term was obsoleted because it did not clearly define a signal transduction pathway.
receptor ligand activity (GO:0048018)
Namespace: molecular_function
Definition: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
Synonyms: agonist; receptor agonist activity; signaling molecule; signaling receptor ligand activity
receptor antagonist activity (GO:0048019)
Namespace: molecular_function
Definition: The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.
Synonyms: receptor ligand activity
CCR chemokine receptor binding (GO:0048020)
Namespace: molecular_function
Definition: Binding to a CCR chemokine receptor.
Synonyms: beta chemokine receptor binding; beta chemokine receptor ligand; CCR chemokine receptor ligand
regulation of melanin biosynthetic process (GO:0048021)
Namespace: biological_process
Definition: Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
Synonyms: regulation of melanin anabolism; regulation of melanin biosynthesis; regulation of melanin formation; regulation of melanin synthesis
negative regulation of melanin biosynthetic process (GO:0048022)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
Synonyms: down regulation of melanin biosynthetic process; down-regulation of melanin biosynthetic process; downregulation of melanin biosynthetic process; inhibition of melanin biosynthetic process; negative regulation of melanin anabolism; negative regulation of melanin biosynthesis; negative regulation of melanin formation; negative regulation of melanin synthesis
positive regulation of melanin biosynthetic process (GO:0048023)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
Synonyms: activation of melanin biosynthetic process; positive regulation of melanin anabolism; positive regulation of melanin biosynthesis; positive regulation of melanin formation; positive regulation of melanin synthesis; stimulation of melanin biosynthetic process; up regulation of melanin biosynthetic process; up-regulation of melanin biosynthetic process; upregulation of melanin biosynthetic process
regulation of mRNA splicing, via spliceosome (GO:0048024)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.
Synonyms: regulation of nuclear mRNA splicing via U2-type spliceosome; regulation of nuclear mRNA splicing, via spliceosome; regulation of pre-mRNA splicing
negative regulation of mRNA splicing, via spliceosome (GO:0048025)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
Synonyms: down regulation of nuclear mRNA splicing via U2-type spliceosome; down regulation of nuclear mRNA splicing, via spliceosome; down-regulation of nuclear mRNA splicing via U2-type spliceosome; down-regulation of nuclear mRNA splicing, via spliceosome; downregulation of nuclear mRNA splicing via U2-type spliceosome; downregulation of nuclear mRNA splicing, via spliceosome; inhibition of nuclear mRNA splicing via U2-type spliceosome; inhibition of nuclear mRNA splicing, via spliceosome; negative regulation of nuclear mRNA splicing via U2-type spliceosome; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of pre-mRNA splicing
positive regulation of mRNA splicing, via spliceosome (GO:0048026)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
Synonyms: activation of nuclear mRNA splicing via U2-type spliceosome; activation of nuclear mRNA splicing, via spliceosome; positive regulation of nuclear mRNA splicing via U2-type spliceosome; positive regulation of nuclear mRNA splicing, via spliceosome; positive regulation of pre-mRNA splicing; stimulation of nuclear mRNA splicing via U2-type spliceosome; stimulation of nuclear mRNA splicing, via spliceosome; up regulation of nuclear mRNA splicing via U2-type spliceosome; up regulation of nuclear mRNA splicing, via spliceosome; up-regulation of nuclear mRNA splicing via U2-type spliceosome; up-regulation of nuclear mRNA splicing, via spliceosome; upregulation of nuclear mRNA splicing via U2-type spliceosome; upregulation of nuclear mRNA splicing, via spliceosome
mRNA 5'-UTR binding (GO:0048027)
Namespace: molecular_function
Definition: Binding to an mRNA molecule at its 5' untranslated region.
Synonyms: mRNA 5' UTR binding
galacturonan binding (GO:0048028)
Namespace: molecular_function
Definition: Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins.
Synonyms: polygalacturonide binding
monosaccharide binding (GO:0048029)
Namespace: molecular_function
Definition: Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
disaccharide binding (GO:0048030)
Namespace: molecular_function
Definition: Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units.
trisaccharide binding (GO:0048031)
Namespace: molecular_function
Definition: Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units.
galacturonate binding (GO:0048032)
Namespace: molecular_function
Definition: Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.
Synonyms: galacturonic acid binding
heme O biosynthetic process (GO:0048034)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle.
Synonyms: haem O biosynthesis; haem O biosynthetic process; heme O anabolism; heme O biosynthesis; heme O formation; heme O synthesis
heme O catabolic process (GO:0048035)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle.
Synonyms: haem O catabolic process; haem O catabolism; heme O breakdown; heme O catabolism; heme O degradation
central complex development (GO:0048036)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli.
Synonyms: central body development
obsolete cofactor binding (GO:0048037)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
Comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a cofactor.
quinone binding (GO:0048038)
Namespace: molecular_function
Definition: Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
ubiquinone binding (GO:0048039)
Namespace: molecular_function
Definition: Binding to ubiquinone, a quinone derivative with a tail of isoprene units.
Synonyms: coenzyme Q binding; coenzyme Q6 binding
UDP-glucuronate decarboxylase activity (GO:0048040)
Namespace: molecular_function
Definition: Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose.
Synonyms: UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming); UDP-D-glucuronate carboxy-lyase activity; UDP-glucuronic acid decarboxylase activity; UDPglucuronate decarboxylase activity; uridine-diphosphoglucuronate decarboxylase activity
focal adhesion assembly (GO:0048041)
Namespace: biological_process
Definition: The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.
Synonyms: adhesion plaque assembly; focal adhesion formation
obsolete trans-pentaprenyltranstransferase activity (GO:0048045)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate.
Synonyms: all-trans-hexaprenyl-diphosphate synthase activity; all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity; hexaprenyl diphosphate synthase activity; hexaprenyl pyrophosphate synthetase activity
Comment: RHEA has obsoleted the xref to this term and replaced it with a term specifying FAD, not NAD
mating behavior, sex discrimination (GO:0048047)
Namespace: biological_process
Definition: The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner.
Synonyms: mating behaviour, sex discrimination
embryonic eye morphogenesis (GO:0048048)
Namespace: biological_process
Definition: The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
post-embryonic eye morphogenesis (GO:0048050)
Namespace: biological_process
Definition: The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight.
R1/R6 cell differentiation (GO:0048052)
Namespace: biological_process
Definition: The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster.
R1/R6 development (GO:0048053)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster.
R2/R5 cell differentiation (GO:0048054)
Namespace: biological_process
Definition: The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster.
R2/R5 development (GO:0048055)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster.
R3/R4 development (GO:0048057)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster.
compound eye corneal lens development (GO:0048058)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells.
negative gravitaxis (GO:0048060)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism away from the source of gravity.
Synonyms: negative geotactic behavior; negative geotactic behaviour; negative gravitactic behavior; negative gravitactic behaviour; negative taxis in response to gravity; negative taxis in response to gravitytaxis in response to gravitational stimulus
positive gravitaxis (GO:0048061)
Namespace: biological_process
Definition: The directed movement of a motile cell or organism towards the source of gravity.
Synonyms: positive geotactic behavior; positive geotactic behaviour; positive gravitactic behavior; positive gravitactic behaviour; positive taxis in response to gravity; positive taxis in response to gravitytaxis in response to gravitational stimulus
male courtship behavior, veined wing extension (GO:0048065)
Namespace: biological_process
Definition: The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster.
Synonyms: male courtship behavior, wing extension; male courtship behaviour, veined wing extension; male courtship behaviour, wing extension
developmental pigmentation (GO:0048066)
Namespace: biological_process
Definition: The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
Synonyms: pigmentation during development
cuticle pigmentation (GO:0048067)
Namespace: biological_process
Definition: Establishment of a pattern of pigment in the cuticle of an organism.
eye pigmentation (GO:0048069)
Namespace: biological_process
Definition: Establishment of a pattern of pigment in the eye of an organism.
regulation of developmental pigmentation (GO:0048070)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
Synonyms: regulation of pigmentation during development
sex-specific pigmentation (GO:0048071)
Namespace: biological_process
Definition: Establishment of a pattern of pigment in one sex that is not observed in the other sex.
regulation of eye pigmentation (GO:0048073)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism.
negative regulation of eye pigmentation (GO:0048074)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism.
Synonyms: down regulation of eye pigmentation; down-regulation of eye pigmentation; downregulation of eye pigmentation; inhibition of eye pigmentation
positive regulation of eye pigmentation (GO:0048075)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism.
Synonyms: activation of eye pigmentation; stimulation of eye pigmentation; up regulation of eye pigmentation; up-regulation of eye pigmentation; upregulation of eye pigmentation
regulation of compound eye pigmentation (GO:0048076)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye.