LiteFold/GO huggingface dataset:
adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.
Synonyms: activation of adenylate cyclase activity by G-protein signaling pathway; activation of adenylate cyclase activity involved in G-protein signaling; adenylate cyclase-activating GPCR signaling pathway; G protein signaling, adenylate cyclase activating pathway; G protein signaling, adenylyl cyclase activating pathway; G protein signalling, adenylate cyclase activating pathway; G protein signalling, adenylyl cyclase activating pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylyl cyclase activating pathway; G-protein signalling, adenylate cyclase activating pathway; G-protein signalling, adenylyl cyclase activating pathway; GPCR signaling pathway via activation of adenylate cyclase; GPCR signaling pathway via activation of adenylate cyclase activity; positive regulation of adenylate cyclase activity by G-protein signaling pathway; positive regulation of adenylate cyclase activity by G-protein signalling pathway; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
Comment: This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway.
activation of adenylate cyclase activity (GO:0007190)
Namespace: biological_process
Definition: Any process that initiates the activity of the inactive enzyme adenylate cyclase.
Synonyms: adenylate cyclase activation; adenylate cyclase activator; adenylyl cyclase activation
adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)
Namespace: biological_process
Definition: An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: activation of adenylate cyclase activity by dopamine receptor signaling pathway; activation of adenylate cyclase activity by dopamine receptor signalling pathway; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, adenylyl cyclase activating pathway
adenylate cyclase-activating serotonin receptor signaling pathway (GO:0007192)
Namespace: biological_process
Definition: An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: activation of adenylate cyclase activity by serotonin receptor signalling pathway; serotonin receptor, adenylate cyclase activating pathway; serotonin receptor, adenylyl cyclase activating pathway
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (GO:0007193)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
Synonyms: adenylate cyclase-inhibiting GPCR signaling pathway; G protein signaling, adenylate cyclase inhibiting pathway; G protein signaling, adenylyl cyclase inhibiting pathway; G protein signalling, adenylate cyclase inhibiting pathway; G protein signalling, adenylyl cyclase inhibiting pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, adenylyl cyclase inhibiting pathway; G-protein signalling, adenylate cyclase inhibiting pathway; G-protein signalling, adenylyl cyclase inhibiting pathway; GPCR signaling pathway via inhibition of adenylate cyclase activity; inhibition of adenylate cyclase activity by G-protein signaling pathway
Comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.
negative regulation of adenylate cyclase activity (GO:0007194)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
Synonyms: adenylate cyclase inhibitor; down regulation of adenylate cyclase activity; down-regulation of adenylate cyclase activity; downregulation of adenylate cyclase activity; inhibition of adenylate cyclase activity; negative regulation of adenylyl cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway (GO:0007195)
Namespace: biological_process
Definition: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: dopamine receptor, adenylate cyclase inhibiting pathway; dopamine receptor, adenylyl cyclase inhibiting pathway; inhibition of adenylate cyclase activity by dopamine receptor signaling pathway; inhibition of adenylate cyclase activity by dopamine receptor signalling pathway
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway (GO:0007196)
Namespace: biological_process
Definition: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway; inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway; inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway; inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (GO:0007197)
Namespace: biological_process
Definition: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway; inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway; inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway (GO:0007198)
Namespace: biological_process
Definition: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: inhibition of adenylate cyclase activity by serotonin receptor signaling pathway; inhibition of adenylate cyclase activity by serotonin receptor signalling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; serotonin receptor, adenylyl cyclase inhibiting pathway
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).
Synonyms: G protein signaling, coupled to cGMP nucleotide second messenger; G protein signalling, coupled to cGMP nucleotide second messenger; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; G-protein signaling, coupled to cGMP nucleotide second messenger; G-protein signalling, coupled to cGMP nucleotide second messenger; GPCR signaling pathway via activation of guanylate cyclase activity; GPCR signaling pathway via cGMP second messenger; guanylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.
Synonyms: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; G protein signaling, coupled to IP3 second messenger (phospholipase C activating); G protein signalling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor signaling pathway coupled to IP3 second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signalling, coupled to IP3 second messenger (phospholipase C activating); phospholipase C-activating G-protein coupled receptor signaling pathway; PLC-activating GPCR signaling pathway; protein kinase C-activating G protein-coupled receptor signaling pathway
obsolete G-protein dissociation (GO:0007201)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: G-protein dissociation
Comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about.
obsolete activation of phospholipase C activity (GO:0007202)
Namespace: biological_process
Definition: OBSOLETE. The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand.
Synonyms: phospholipase C activation
Comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'.\nThe reason for obsoletion is that this term represents a molecular function.
obsolete phosphatidylinositol-4,5-bisphosphate hydrolysis (GO:0007203)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: phosphatidylinositol-4,5-bisphosphate hydrolysis
Comment: This term was made obsolete because hydrolysis is a reaction, not a process.
positive regulation of cytosolic calcium ion concentration (GO:0007204)
Namespace: biological_process
Definition: Any process that increases the concentration of calcium ions in the cytosol.
Synonyms: cytoplasmic calcium ion concentration elevation; cytosolic calcium ion concentration elevation; elevation of calcium ion concentration in cytoplasm; elevation of calcium ion concentration in cytosol; elevation of cytoplasmic calcium ion concentration; elevation of cytosolic calcium ion concentration
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway (GO:0007207)
Namespace: biological_process
Definition: A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway; activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway; activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; muscarinic receptor signaling pathway via activation of PLC; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway (GO:0007208)
Namespace: biological_process
Definition: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: activation of phospholipase C activity by serotonin receptor signaling pathway; activation of phospholipase C activity by serotonin receptor signalling pathway; serotonin receptor, phospholipase C activating pathway
phospholipase C-activating tachykinin receptor signaling pathway (GO:0007209)
Namespace: biological_process
Definition: A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: activation of phospholipase C activity by tachykinin receptor signaling pathway; activation of phospholipase C activity by tachykinin receptor signalling pathway; tachykinin receptor, phospholipase C activating pathway
serotonin receptor signaling pathway (GO:0007210)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
Synonyms: serotonin receptor signalling pathway
octopamine or tyramine signaling pathway (GO:0007211)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by octopamine or tyramine binding to their receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription, and ending with the regulation of a downstream cellular process. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters.
Synonyms: octopamine or tyramine signalling pathway; octopamine/tyramine signaling pathway
G protein-coupled dopamine receptor signaling pathway (GO:0007212)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: dopamine receptor signalling pathway
G protein-coupled acetylcholine receptor signaling pathway (GO:0007213)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms: acetylcholine receptor signalling, muscarinic pathway; G-protein coupled acetylcholine receptor signaling pathway; muscarinic acetylcholine receptor signaling pathway
gamma-aminobutyric acid signaling pathway (GO:0007214)
Namespace: biological_process
Definition: The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.
Synonyms: 4-aminobutanoate signaling pathway; 4-aminobutanoate signalling pathway; 4-aminobutyrate signaling pathway; 4-aminobutyrate signalling pathway; GABA signaling pathway; GABA signalling pathway; gamma-aminobutyric acid signalling pathway
glutamate receptor signaling pathway (GO:0007215)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: glutamate signaling pathway; glutamate signalling pathway
G protein-coupled glutamate receptor signaling pathway (GO:0007216)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: G-protein coupled glutamate receptor signaling pathway; metabotropic glutamate receptor signaling pathway; metabotropic glutamate receptor signalling pathway
tachykinin receptor signaling pathway (GO:0007217)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2).
Synonyms: tachykinin signalling pathway
neuropeptide signaling pathway (GO:0007218)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: neuropeptide signalling pathway
Notch signaling pathway (GO:0007219)
Namespace: biological_process
Definition: The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: N signaling pathway; N signalling pathway; Notch receptor signaling pathway; Notch receptor signalling pathway; Notch signalling pathway; Notch-receptor signaling pathway; Notch-receptor signalling pathway
Notch receptor processing (GO:0007220)
Namespace: biological_process
Definition: The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor.
Synonyms: N receptor processing
positive regulation of transcription of Notch receptor target (GO:0007221)
Namespace: biological_process
Definition: The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.
Synonyms: N receptor target transcription factor activation; Notch receptor target transcription factor activation
Wnt signaling pathway, calcium modulating pathway (GO:0007223)
Namespace: biological_process
Definition: A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface of a target cell leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
Synonyms: frizzled-2 signaling pathway; frizzled-2 signalling pathway; non-canonical Wnt signaling pathway; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated signaling pathway, calcium modulating pathway
smoothened signaling pathway (GO:0007224)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
Synonyms: hedgehog signaling pathway; hh signaling pathway; hh signalling pathway; Shh signaling pathway; smoothened signalling pathway; Sonic hedgehog signaling pathway
patched ligand maturation (GO:0007225)
Namespace: biological_process
Definition: The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.
Synonyms: Hedgehog protein processing; hh protein processing; patched ligand processing
obsolete signal transduction downstream of smoothened (GO:0007227)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
Comment: This term was obsoleted because it represents the same pathway as smoothened signaling pathway ; GO:0007224.
obsolete positive regulation of hh target transcription factor activity (GO:0007228)
Namespace: biological_process
Definition: OBSOLETE. Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited.
Synonyms: activation of hh target transcription factor; positive regulation of hedgehog target transcription factor
Comment: This term was obsoleted because it represents a readout.
integrin-mediated signaling pathway (GO:0007229)
Namespace: biological_process
Definition: The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: integrin-mediated signalling pathway
obsolete calcium-o-sensing receptor pathway (GO:0007230)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: calcium-o-sensing receptor pathway
Comment: This term was made obsolete because it does not make sense.
osmosensory signaling pathway (GO:0007231)
Namespace: biological_process
Definition: The series of molecular signals initiated in response to osmotic change.
Synonyms: osmolarity sensing; osmolarity sensing signaling pathway; osmolarity sensing signalling pathway; osmosensory signal transduction; osmosensory signalling pathway; signal transduction during osmotic stress
osmosensory signaling pathway via Sho1 osmosensor (GO:0007232)
Namespace: biological_process
Definition: The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system.
Synonyms: osmosensory signalling pathway via Sho1 osmosensor; signal transduction during osmotic stress via Sho1 osmosensor
osmosensory signaling via phosphorelay pathway (GO:0007234)
Namespace: biological_process
Definition: The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. In S.cerevisiae, the osmosensor is the histidine kinase Sln1.
Synonyms: osmolarity sensing via two-component system; osmolarity signaling pathway via two-component system; osmolarity signalling pathway via two-component system; osmosensory signaling pathway via two-component system; osmosensory signalling pathway via two-component system; signal transduction during osmotic stress via two-component system
obsolete activation of Ypd1 protein (GO:0007235)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: activation of Ypd1 protein
Comment: This term was made obsolete because it contains gene product and species specific information.
obsolete activation of Ssk1 protein (GO:0007236)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: activation of Ssk1 protein
Comment: This term was made obsolete because it contains gene product and species specific information.
obsolete activation of Ssk2/Ssk22 proteins (GO:0007237)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: activation of Ssk2/Ssk22 proteins
Comment: This term was made obsolete because it contains gene product and species specific information.