LiteFold/GO huggingface dataset:
lovastatin biosynthetic process (GO:0140735)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR).
Synonyms: lovastatin anabolism; lovastatin biosynthesis; lovastatin formation; lovastatin synthesis; mevacor anabolism; mevacor biosynthesis; mevacor biosynthetic process; mevacor formation; mevacor synthesis; mevinolin anabolism; mevinolin biosynthesis; mevinolin biosynthetic process; mevinolin formation,; mevinolin synthesis; monacolin K anabolism; monacolin K biosynthesis; monacolin K biosynthetic process; monacolin K formation; monacolin K synthesis
positive regulation of lovastatin biosynthetic process (GO:0140736)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of lovastin.
Synonyms: positive regulation of mevacor biosynthetic process; positive regulation of mevinolin biosynthetic process; positive regulation of monacolin K biosynthetic process
encapsulin nanocompartment (GO:0140737)
Namespace: cellular_component
Definition: Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla.
Synonyms: protein nanocompartment
NLRP6 inflammasome complex (GO:0140738)
Namespace: cellular_component
Definition: An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11.
ADP-riboxanase activity (GO:0140740)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4+ + nicotinamide.
Comment: Note that this activity has two steps: a transfer of an ADP-ribose group, followed by the elimination of an ammonia group.
lncRNA transcription (GO:0140742)
Namespace: biological_process
Definition: The transcription of lncRNAs, non-coding RNAs over 200 nucleotides in length, from a DNA template.
regulation of lncRNA transcription (GO:0140743)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the synthesis of a lncRNA.
negative regulation of lncRNA transcription (GO:0140744)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of the synthesis of a lncRNA.
siRNA transcription (GO:0140745)
Namespace: biological_process
Definition: The transcription of a small interfering RNA from an RNA template.
siRNA catabolic process (GO:0140746)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of small interfering RNA transcripts (siRNAs).
obsolete regulation of ncRNA transcription (GO:0140747)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template.
Comment: The reason for obsoletion is that this term was added in error.
phlorizin hydrolase activity (GO:0140749)
Namespace: molecular_function
Definition: Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin.
nucleosome array spacer activity (GO:0140750)
Namespace: molecular_function
Definition: A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair.
Synonyms: nucleosome array spacing activity
Comment: In Drosphila, this is mediated by ISWI, in human, by SMARCA5 and in S. cerevisiae by ISW1 and and ISW2.
histone octamer slider activity (GO:0140751)
Namespace: molecular_function
Definition: A chromatin remodeler activity that slides core histone octamers along chromosomal DNA.
Synonyms: histone octamer sliding activity
Comment: This activity is mediated by at least three subfamilies of the SNF2 remodellers, namely the bromodomain domain, the chromodomain containing and the imitation switch subfamilies.
branched 1,3-beta-D-glucan synthase activity (GO:0140752)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1).
linear 1,3-beta-D-glucan synthase activity (GO:0140753)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1).
reorganization of cellular membranes to establish viral sites of replication (GO:0140754)
Namespace: biological_process
Definition: A process in intracellular membranes are reorganized by viral proteins that perturb membrane integrity and can cause an extensive rearrangement of cellular membranes, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus.
reorganization of host cellular membranes to establish sites of replication (GO:0140755)
Namespace: biological_process
Definition: A process in which a virus triggers host intracellular membranes to be reorganized, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus.
structural constituent of proteasome (GO:0140756)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of the proteasome.
cysteine-type deNEDDylase activity (GO:0140757)
Namespace: molecular_function
Definition: An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
metal-dependent deNEDDylase activity (GO:0140758)
Namespace: molecular_function
Definition: An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
histone H3K56 methyltransferase activity (GO:0140759)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein.
Synonyms: histone H3K56 methylase activity; histone lysine N-methyltransferase activity (H3-K56 specific); histone methyltransferase activity (H3-K56 specific); histone-H3K56 methyltransferase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone H3K56me2/H3K56me3 demethylase activity (GO:0140760)
Namespace: molecular_function
Definition: Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein.
Synonyms: histone demethylase activity (H3-K56 specific); histone H3-tri/dimethyl-lysine-56 demethylase activity; histone H3K56me2 demethylase activity; histone H3K56me3 demethylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity (GO:0140761)
Namespace: molecular_function
Definition: Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin.
Synonyms: calcium- and calmodulin-regulated 3',5'-cyclic-AMP phosphodiesterase activity; calcium- and calmodulin-regulated AMP-specific phosphodiesterase activity; calcium- and calmodulin-regulated cAMP phosphodiesterase activity; calcium- and calmodulin-regulated cyclic-AMP phosphodiesterase activity; calcium/calmodulin-regulated cAMP-specific phosphodiesterase activity
glucose dehydrogenase (FAD, quinone) activity (GO:0140762)
Namespace: molecular_function
Definition: Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone.
programmed DNA elimination by elimination of internal DNA segments (GO:0140763)
Namespace: biological_process
Definition: A programmed DNA elimination mechanism in which specific sequences, namely, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the genome. This process is known to occur in ciliates.
small RNA binding translational repressor activity (GO:0140764)
Namespace: molecular_function
Definition: A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA.
Comment: This term is intended for activities such as that mediated by argonaute in the RISC complex, that bring a miRNA or an siRNA to their target mRNA.
histone H3K56 deacetylase activity, NAD-dependent (GO:0140765)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + NAD+ + H2O = histone H3 L-lysine (position 56) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K56 to NAD, producing nicotinamide.
Synonyms: NAD-dependent histone deacetylase activity (H3-K56 specific); NAD-dependent histone H3-K56 deacetylase activity; NAD-dependent histone H3K56 deacetylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
siRNA-mediated post-transcriptional gene silencing (GO:0140766)
Namespace: biological_process
Definition: A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants.
Synonyms: gene silencing by siRNA; post-transcriptional gene silencing by siRNA; posttranscriptional gene silencing by siRNA; siRNA-mediated gene silencing; siRNA-mediated PTGS
enzyme-substrate adaptor activity (GO:0140767)
Namespace: molecular_function
Definition: An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity.
Synonyms: protein substrate chaperone activity; protein-substrate adaptor activity
protein ADP-ribosyltransferase-substrate adaptor activity (GO:0140768)
Namespace: molecular_function
Definition: An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate.
ACP-dependent peptidyl-lysine N6-myristoyltransferase activity (GO:0140769)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H+ + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein].
CoA-dependent peptidyl-lysine N6-myristoyltransferase activity (GO:0140770)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-[protein].
ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity (GO:0140771)
Namespace: molecular_function
Definition: Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H+ + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein].
CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity (GO:0140772)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-[protein].
NAD-dependent protein demyristoylase activity (GO:0140773)
Namespace: molecular_function
Definition: Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
actin filament debranching activity (GO:0140775)
Namespace: molecular_function
Definition: Binding to an actin filament and promoting the dissociation of an actin filament branch.
Synonyms: actin debranching activity
protein-containing complex stabilizing activity (GO:0140777)
Namespace: molecular_function
Definition: A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex.
microtubule stabilizing activity (GO:0140778)
Namespace: molecular_function
Definition: A protein-containing complex stabilizing activity that prevents dissociation of microtubules.
XCL1 production (GO:0140779)
Namespace: biological_process
Definition: The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: lymphotactin production
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
obsolete modulation by symbiont of host system process (GO:0140780)
Namespace: biological_process
Definition: OBSOLETE. The process in which a symbiont organism effects a change in an anatomical system process of its host organism.
Comment: This term was obsoleted because it is not sufficiently precise.
ilicicolin H biosynthetic process (GO:0140781)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of ilicicolin H, a 4-hydroxy-2-pyridone alkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain.
Synonyms: ilicicolin H anabolism; ilicicolin H biosynthesis; ilicicolin H formation; ilicicolin H synthesis
(M)-viriditoxin biosynthetic process (GO:0140783)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of (M)-viriditoxin, a fungal secondary metabolite with antibacterial activity.
Synonyms: (M)-viriditoxin anabolism; (M)-viriditoxin biosynthesis; (M)-viriditoxin formation; (M)-viriditoxin synthesis; viriditoxin anabolism; viriditoxin biosynthesis; viriditoxin formation; viriditoxin synthesis
metal ion sensor activity (GO:0140784)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion.
amino acid sensor activity (GO:0140785)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid.
Synonyms: amino acid sensing activity
glutamine sensor activity (GO:0140786)
Namespace: molecular_function
Definition: Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine.
Synonyms: glutamine sensing activity
phosphate ion uniporter activity (GO:0140787)
Namespace: molecular_function
Definition: Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.
L-glutamate uniporter activity (GO:0140788)
Namespace: molecular_function
Definition: Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.
Synonyms: glutamate uniporter activity
histone phosphatase activity (GO:0140789)
Namespace: molecular_function
Definition: Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate.
obsolete histone serine/threonine phosphatase activity (GO:0140790)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: histone serine phosphate + H2O = histone serine + phosphate, and histone threonine phosphate + H2O = histone threonine + phosphate.
Comment: This term was obsoleted because it represents an unnecessary grouping class.
histone H2AXS139 phosphatase activity (GO:0140791)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H2AX serine phosphate (position 139) + H2O = histone H2AX serine (position 139) + phosphate.
Synonyms: histone H2-S140 serine phosphatase activity; histone H2S140 phosphatase activity; histone serine phosphatase activity (H2-S140 specific)
Comment: Note that the residue position corresponds to the canonical human H2AX histone (UniProtKB:P16104); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
obsolete histone tyrosine phosphatase activity (GO:0140792)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: histone tyrosine phosphate + H2O = histone tyrosine + phosphate.
Comment: This term was obsoleted because it represents an unnecessary grouping class.
histone H2AXY142 phosphatase activity (GO:0140793)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate.
Synonyms: histone H2-Y142 phosphatase activity; histone H2Y142 phosphatase activity; histone tyrosine phosphatase activity (H2-Y142 specific)
Comment: Note that the residue position corresponds to the canonical human H2AX histone (UniProtKB:P16104); this residue is conserved in mammals, but missing from tetrahymena. This residue is present in Drosophila histone H2AV. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
histone arginine deiminase activity (GO:0140794)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination.
Synonyms: histone citrullination; histone-arginine deiminase activity
Comment: The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
histone H3R2 arginine deiminase activity (GO:0140795)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone H3 L-arginyl (position 2)= histone H3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2.
Synonyms: H3-R2 citrullination; histone H3-R2 arginine deiminase activity; histone-arginine deiminase activity (H3-R2 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism. The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
histone H3R8 arginine deiminase activity (GO:0140796)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8.
Synonyms: H3-R8 citrullination; histone H3-R8 arginine deiminase activity; histone-arginine deiminase activity (H3-R8 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism. The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
histone H3R17 arginine deiminase activity (GO:0140797)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17.
Synonyms: H3-R17 citrullination; histone H3-R17 arginine deiminase activity; histone-arginine deiminase activity (H3-R17 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism. The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
glycine:proton antiporter activity (GO:0140799)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out).
gamma-aminobutyric acid:proton antiporter activity (GO:0140800)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out).
histone H2AXY142 kinase activity (GO:0140801)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX.
Synonyms: gamma-H2AX-S142 kinase activity; histone H2AX-Y142 kinase activity; histone H2AY142 kinase activity; histone kinase activity (H2AX-Y142 specific)
Comment: Note that the residue position corresponds to the canonical human H2AX histone (UniProtKB:P16104); this residue is conserved in mammals, but missing from tetrahymena. This residue is present in Drosophila histone H2AV. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity (GO:0140802)
Namespace: molecular_function
Definition: Catalysis of the reaction: [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide.
NAD+-protein-cysteine ADP-ribosyltransferase activity (GO:0140803)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein].