LiteFold/GO huggingface dataset:
symbiont-mediated suppression of host immunoglobulin-mediated immune response (GO:0141140)
Namespace: biological_process
Definition: A process in which a symbiont interferes with, inhibits or disrupts the normal execution of the immunoglobulin-mediated immune response of the host organism. One common mechanism by which this happens is the direct inhibition of immunoglobulin activity, by direct binding or modification. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated suppression of host immunoglobulin activity
symbiont-mediated evasion of recognition by host pattern recognition receptor (GO:0141141)
Namespace: biological_process
Definition: A process by which a symbiont avoids recognition by host's innate immune response by altering or concealing a conserved molecule recognized by the host's cell surface and intracellular pattern recognition receptors, including Toll-like and NOD-like receptors. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: evasion of symbiont recognition by host pattern recognition receptor
Comment: Note that this term should be used when the symbiont in cases where the symbiont modifies its own molecules (proteins, DNA, RNA, lipids) to avoid recognition by the host. In cases where the symbiont  directly inhibits a component of a host cytoplasmic receptor signaling pathway, consider annotating to evasion of symbiont recognition by host pattern recognition receptor ; GO:0039537.
symbiont-mediated migration across host tissue barrier (GO:0141142)
Namespace: biological_process
Definition: A process in which a symbiont moves across a tissue barrier of the host to transports itself across an extracellular cellular matrix barrier or between the cells of a tissue. This involves the temporary or permanent breaching of the tissue barrier.
obsolete symbiont-mediated disruption of host cell adhesion to extracellular matrix (GO:0141143)
Namespace: biological_process
Definition: OBSOLETE. A process in which a symbiont alters or subverts cell adhesion to the extracellular matrix in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption by symbiont of host cell adhesion to extracellular matrix
Comment: This term was obsoleted because it was created by mistake.
symbiont-mediated disruption of host neutrophil extracellular traps (GO:0141144)
Namespace: biological_process
Definition: A process in which a symbiont damages or impairs host neutrophil extracellular traps. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated perturbation of host neutrophil extracellular traps
symbiont-mediated suppression of host neutrophil extracellular trap formation (GO:0141145)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the formation of neutrophil extracellular traps by the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated perturbation of host neutrophil extracellular trap formation; symbiont-mediated suppression of host neutrophil extracellular traps formation
symbiont-mediated disruption of host tissue (GO:0141146)
Namespace: biological_process
Definition: The process in which an organism effects a change that impairs the structure or function of a host tissue. This can occur via the disruption of the extracellular matrix, or the detachment of cells from the extracellular matrix, or the dissociation of the cells composing that tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: cytopathogenic effect
intracellularly calcium-gated channel activity (GO:0141147)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a solute by a channel that opens when calcium ions bind on the intracellular side of the channel complex or one of its constituent parts.
enoyl-[acyl-carrier-protein] reductase (NADPH) activity (GO:0141148)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH.
Comment: This reaction completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. Note that EC has reactions describing the stereo-specificity of the reaction with respect to NADP+ (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.104).
regulation of nitric oxide-cGMP mediated signal transduction (GO:0141149)
Namespace: biological_process
Definition: Any process that modulates the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
positive regulation of nitric oxide-cGMP mediated signal transduction (GO:0141150)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
negative regulation of nitric oxide-cGMP mediated signal transduction (GO:0141151)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
glycerol-3-phosphate dehydrogenase (NAD+) activity (GO:0141152)
Namespace: molecular_function
Definition: Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.
Synonyms: alpha-glycerol phosphate dehydrogenase (NAD) activity; alpha-glycerophosphate dehydrogenase (NAD) activity; glycerol 1-phosphate dehydrogenase activity; glycerol phosphate dehydrogenase (NAD) activity; glycerol-3-phosphate dehydrogenase (NAD) activity; glycerol-3-phosphate dehydrogenase [NAD+] activity; glycerophosphate dehydrogenase (NAD) activity; hydroglycerophosphate dehydrogenase activity; L-alpha-glycerol phosphate dehydrogenase activity; L-alpha-glycerophosphate dehydrogenase activity; L-glycerol phosphate dehydrogenase activity; L-glycerophosphate dehydrogenase activity; NAD-alpha-glycerophosphate dehydrogenase activity; NAD-dependent glycerol phosphate dehydrogenase activity; NAD-dependent glycerol-3-phosphate dehydrogenase activity; NAD-L-glycerol-3-phosphate dehydrogenase activity; NAD-linked glycerol 3-phosphate dehydrogenase activity; NADH-dihydroxyacetone phosphate reductase activity
glycerol-3-phosphate dehydrogenase (NADP+) activity (GO:0141153)
Namespace: molecular_function
Definition: NADP+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADPH.
Synonyms: glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity; glycerol-3-phosphate dehydrogenase [NADP+] activity; L-glycerol-3-phosphate:NADP oxidoreductase activity
symbiont-mediated suppression of host-directed shutoff of host translation (GO:0141154)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host translation elongation (GO:0141155)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the translation elongation of host mRNA into protein, for example by directly inhibiting elongation factors. The host is defined as the larger of the organisms involved in a symbiotic interaction.
cAMP/PKA signal transduction (GO:0141156)
Namespace: biological_process
Definition: An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell.
Synonyms: cAMP signaling; cAMP/PKA signaling cassette; PKA signaling; protein kinase A signaling
symbiont-mediated suppression of host exocytosis (GO:0141157)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the normal execution of  host exocytosis. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host phagosome maturation (GO:0141158)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the normal maturation of host phagosomes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host phagosome acidification (GO:0141159)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the normal acidification of host phagosomes. Mechanisms by which a symbiont prevents host phagosome acidification include the inhibitition of host V-ATPase, the proton pump that acidifies the phagosome, or disruption of the phagosome membrane by pore-forming toxin. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated disruption of host phagosome (GO:0141160)
Namespace: biological_process
Definition: The process in which an organism effects a change that impairs the structure or function of host phagosomes.
regulation of cAMP/PKA signal transduction (GO:0141161)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of cAMP/PKA signal transduction.
Synonyms: regulation of cAMP/PKA signaling
negative regulation of cAMP/PKA signal transduction (GO:0141162)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of cAMP/PKA signal transduction.
Synonyms: negative regulation of cAMP/PKA signaling
positive regulation of cAMP/PKA signal transduction (GO:0141163)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cAMP/PKA signal transduction.
Synonyms: positive regulation of cAMP/PKA signaling
glucosinolate transmembrane transporter activity (GO:0141165)
Namespace: molecular_function
Definition: Enables the transfer of a glucosinolate across a membrane.
chromosomal 5-methylcytosine DNA demethylation, oxidation pathway (GO:0141167)
Namespace: biological_process
Definition: An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC).  A DNA glycosylase (e. g. TDG) recognizes the  intermediate bases 5fC and 5caC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair.
Synonyms: epigenetic 5-methylcytosine DNA demethylation, oxidation pathway; epigenetic DNA demethylation, oxidation pathway
Comment: Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child. A similar pathway may also convert chromosomal DNA N6-methyladenosine to adenosine but little evidence exists for this pathway.
chromosomal 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway (GO:0141169)
Namespace: biological_process
Definition: An epigenetic cytosine DNA demethylation pathway that involves a DNA glycosylase that directly excises 5-methylcytosine (5-meC) to initiate its replacement with unmethylated cytosine through base excision repair. This pathway is known to occur in plants. In addition to CG sites, plants also methylate cytosines within CHH and CNG sequences.
Synonyms: epigenetic 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway
Comment: Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child.
positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway (GO:0141170)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway.
symbiont-mediated perturbation of host membrane (GO:0141171)
Namespace: biological_process
Definition: The process in which a symbiont effects a change that impairs the structure or function of a host membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated disruption of host membrane
symbiont-mediated suppression of host pro-inflammatory cytokine signaling (GO:0141173)
Namespace: biological_process
Definition: A process by which a symbiont inhibits or disrupts pro-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway. Pro-inflammatory cytokines include: IL-1, IL-12, IL-18, TNF, IFN-gamma, and GM-CSF. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: negative regulation by symbiont of host pro-inflammatory cytokine production; suppression by symbiont of host pro-inflammatory cytokine production; suppression by symbiont of host pro-inflammatory cytokine secretion; symbiont-mediated degradation of host pro-inflammatory cytokine; symbiont-mediated sequestering of host pro-inflammatory cytokine; symbiont-mediated suppression of host pro-inflammatory cytokine production
symbiont-mediated suppression of host anti-inflammatory cytokine signaling (GO:0141174)
Namespace: biological_process
Definition: A process by which a symbiont inhibits or disrupts anti-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway.  Anti-inflammatory cytokines include: interleukin (IL)-1, IL-4, IL-6, IL-10, IL-11, and IL-13. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: negative regulation by symbiont of host anti-inflammatory cytokine production; suppression by symbiont of host anti-inflammatory cytokine production; suppression by symbiont of host anti-inflammatory cytokine secretion; symbiont-mediated degradation of host anti-inflammatory cytokine; symbiont-mediated sequestering of host anti-inflammatory cytokine; symbiont-mediated suppression of host anti-inflammatory cytokine production
receptor clustering activity (GO:0141175)
Namespace: molecular_function
Definition: A protein-protein adaptor that acts as a platform for receptor clustering, often serving to amplify the sensitivity of a signaling response.
gene silencing by piRNA-directed DNA methylation (GO:0141176)
Namespace: biological_process
Definition: A small RNA-based gene silencing process in which Piwi-associated RNAs (piRNAs) guide de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.
symbiont-mediated evasion of recognition by host innate immune effector (GO:0141177)
Namespace: biological_process
Definition: A process by which a symbiont mitigates the effects of recognition by a host innate immune effector. Effectors have a direct activity against a symbiont and include complement, antimicrobial peptides, and bacterial restriction enzymes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: evasion of symbiont recognition by host innate immune effector
symbiont-mediated evasion of recognition by host complement (GO:0141178)
Namespace: biological_process
Definition: A process by which a symbiont avoids the effects of recognition by host  complement by altering molecules on the symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: symbiont-mediated evasion of host complement
symbiont-mediated evasion of recognition by host antimicrobial peptide (GO:0141179)
Namespace: biological_process
Definition: A process by which a symbiont avoids the effects of recognition by a host  antimicrobial peptide by altering molecules on the symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated activation of host anti-inflammatory cytokine signaling (GO:0141184)
Namespace: biological_process
Definition: A process in which a symbiont subverts an anti-inflammatory cytokine signaling pathway in the host organism by initiating, promoting, or enhancing its activation.
UFM1-modified protein reader activity (GO:0141185)
Namespace: molecular_function
Definition: A molecular adaptor recognizes and binds a target protein containing a UFM1 modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
Synonyms: UFM1 modified protein reader activity; UFM1-dependent protein binding
nucleic acid biosynthetic process (GO:0141187)
Namespace: biological_process
Definition: The biosynthetic process resulting in the formation of a nucleic acid.
Comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
nucleic acid catabolic process (GO:0141188)
Namespace: biological_process
Definition: The cellular DNA metabolic process resulting in the breakdown of a nucleic acid.
Comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
obsolete G protein mediated opsin signaling pathway (GO:0141189)
Namespace: biological_process
Definition: OBSOLETE. A phospholipase C-activating receptor G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and ending with the light signal being trasmitted through the synapses. Opsins are G-protein coupled receptors which bind light-sensitive chromophores.
Synonyms: G protein-mediated opsin signaling pathway; phospholipase C-activating G protein-mediated phototransduction signaling pathway; phospholipase C-activating phototransduction signaling pathway; phospholipase C-activating phototransduction-mediated G-protein coupled receptor signaling pathway; phototransduction-mediated G protein signaling, coupled to IP3 second messenger; phototransduction-mediated G protein signalling, coupled to IP3 second messenger; phototransduction-mediated G-protein signaling, coupled to IP3 second messenger; phototransduction-mediated G-protein signalling, coupled to IP3 second messenger; PLC-activating phototransduction-mediated signaling pathway
Comment: This term was obsoleted because it was created by mistake; it represents the same process as G protein-mediated opsin signaling pathway ; GO:0030265.
transducin-mediated opsin signaling pathway (GO:0141190)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway that starts with an opsin molecule being activated by a photon. Opsins include rhodopsin and others visual receptors bind heterotrimeric transducin G proteins upon activation. Activated transducin alpha-subunit activates cGMP phosphodiesterase, which breaks down cGMP. The decrease in cGMP concentration leads to closure of cGMP-gated (CNG) channels, blockage of Na+ influx, and hyperpolarization of photoreceptor plasma membrane, leading to transmission of signal through synapses. The signal is terminated by phosphorylation of the C-terminal tail of rhodopsin by rhodopsin kinase to allow arrestin to bind and block G protein binding. Typical examples are rhabdomeric photoreceptors in the eyes of deuterostomes.
Synonyms: cGMP-mediated opsin signaling pathway; cGMP-mediated rhodopsin signaling pathway; ciliary opsin-mediated signaling pathway; cyclic-GMP-mediated opsin signaling pathway; cyclic-nucleotide-mediated opsin signaling pathway; Gt-mediated opsin signaling pathway
negative regulation of HRI-mediated signaling (GO:0141191)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of HRI-mediated signaling.
nuclear receptor-mediated signaling pathway (GO:0141193)
Namespace: biological_process
Definition: The series of molecular signals initiated by a signaling molecule binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: nuclear receptor signaling pathway
siRNA-mediated heterochromatin formation (GO:0141194)
Namespace: biological_process
Definition: The formation of heterochromatin into a heterochromatin domain by a process mediated by a small interfering siRNA.
obsolete piRNA-mediated facultative heterochromatin formation (GO:0141195)
Namespace: biological_process
Definition: OBSOLETE. The formation of facultative heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a Piwi-associated RNA (piRNA).
Comment: This term was obsoleted because the evidence is too weak to implicate piRNAs in facultative heterochromatin formation.
transposable element silencing by piRNA-mediated DNA methylation (GO:0141196)
Namespace: biological_process
Definition: A transposable element silencing mechanism mediated by Piwi-associated RNA (piRNA)-directed DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.
Synonyms: retrotransposon silencing by piRNA-directed DNA methylation; transposable element silencing by piRNA-directed DNA methylation
4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin) (GO:0141197)
Namespace: molecular_function
Definition: Catalysis of the reaction: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin].
Synonyms: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
protein branched polyubiquitination (GO:0141198)
Namespace: biological_process
Definition: A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at various positions of the ubiquitin monomers, forming branched linkages, such as K11/K48- or K11/K63-linked chains.
obsolete GDP-mannose biosynthetic process from glucose (GO:0141199)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of GDP-mannose from glucose.
Comment: This term was obsoleted because it represents the same process as GDP-mannose biosynthetic process from fructose-6-phosphate ; GO:0061729.
UTP thiamine diphosphokinase activity (GO:0141200)
Namespace: molecular_function
Definition: Catalysis of the reaction: UTP + thiamine = UMP + thiamine diphosphate.
pyroptotic cell death (GO:0141201)
Namespace: biological_process
Definition: A inflammatory cell death process associated with the generation of pyrogenic mediators that result from the activation of gasdermins.
Synonyms: pyroptosis
symbiont-mediated suppression of host complement activation by activation of host proteases (GO:0141203)
Namespace: biological_process
Definition: A process by which a symbiont prevents host complement activation by recruiting host proteases, destroying the complement before it has its effect on the symbiont.
Synonyms: symbiont-mediated suppression of host complement activation by recruitment of host proteases