LiteFold/GO huggingface dataset:
AV node cell to bundle of His cell communication (GO:0086067)
Namespace: biological_process
Definition: The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Synonyms: atrioventricular node cell to bundle of His cell communication
Purkinje myocyte to ventricular cardiac muscle cell communication (GO:0086068)
Namespace: biological_process
Definition: The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
bundle of His cell to Purkinje myocyte communication (GO:0086069)
Namespace: biological_process
Definition: The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Synonyms: atrioventricular junction myocyte to bundle branch myocyte; bundle branch myocyte to Purkinje myocyte communication; bundle of His cardiac muscle cell to Purkinje myocyte communication; bundle of His myocyte to atrioventricular junction myocyte; ventricular conduction system cell to cell communication
SA node cell to atrial cardiac muscle cell communication (GO:0086070)
Namespace: biological_process
Definition: The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
Synonyms: SA node cardiac muscle cell to atrial cardiac muscle cell communication; SA node cardiomyocyte to atrial cardiomyocyte communication; SAN cardiomyocyte to atrial cardiomyocyte communication; sinoatrial node cardiomyocyte to atrial cardiomyocyte communication; sinus node cardiomyocyte to atrial cardiomyocyte communication
obsolete atrial cardiac muscle cell-AV node cell adhesion involved in cell communication (GO:0086071)
Namespace: biological_process
Definition: OBSOLETE. The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
Synonyms: atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication; atrial cardiomyocyte-AV node cell adhesion involved in cell communication
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
AV node cell-bundle of His cell adhesion involved in cell communication (GO:0086072)
Namespace: biological_process
Definition: The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
Synonyms: atrioventricular node cell-bundle of His cell adhesion involved in cell communication
bundle of His cell-Purkinje myocyte adhesion involved in cell communication (GO:0086073)
Namespace: biological_process
Definition: The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
obsolete Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication (GO:0086074)
Namespace: biological_process
Definition: OBSOLETE. The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
gap junction channel activity involved in cardiac conduction electrical coupling (GO:0086075)
Namespace: molecular_function
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling (GO:0086076)
Namespace: molecular_function
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
Synonyms: gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling; gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling (GO:0086077)
Namespace: molecular_function
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
Synonyms: gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling (GO:0086078)
Namespace: molecular_function
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling (GO:0086079)
Namespace: molecular_function
Definition: A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
protein binding involved in heterotypic cell-cell adhesion (GO:0086080)
Namespace: molecular_function
Definition: Binding to a protein or protein complex contributing to the adhesion of two different types of cells.
obsolete cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication (GO:0086081)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells.
Synonyms: cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication; cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
cell adhesive protein binding involved in AV node cell-bundle of His cell communication (GO:0086082)
Namespace: molecular_function
Definition: Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.
Synonyms: cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (GO:0086083)
Namespace: molecular_function
Definition: Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.
obsolete cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication (GO:0086084)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication (GO:0086085)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells.
Synonyms: cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete voltage-gated potassium channel activity involved in AV node cell action potential repolarization (GO:0086086)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential; voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization (GO:0086087)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
obsolete voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization (GO:0086088)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization (GO:0086089)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization
voltage-gated potassium channel activity involved in SA node cell action potential repolarization (GO:0086090)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage-gated potassium channel activity involved in SAN cell action potential; voltage-gated potassium channel activity involved in sinoatrial node cell action potential; voltage-gated potassium channel activity involved in sinus node cell action potential
regulation of heart rate by cardiac conduction (GO:0086091)
Namespace: biological_process
Definition: A cardiac conduction process that modulates the frequency or rate of heart contraction.
obsolete G protein-coupled acetylcholine receptor signaling pathway involved in heart process (GO:0086093)
Namespace: biological_process
Definition: OBSOLETE. A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart.
Synonyms: G-protein coupled acetylcholine receptor signaling pathway involved in heart process; G-protein coupled acetylcholine receptor signalling pathway involved in heart process; M2 receptor signaling pathway involved in heart process; muscarinic receptor signaling pathway involved in heart process
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction (GO:0086094)
Namespace: biological_process
Definition: OBSOLETE. An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction.
Synonyms: adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086095)
Namespace: biological_process
Definition: OBSOLETE. A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate.
Synonyms: cardiac muscarinic receptor signaling via Gbeta/gamma; Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate; muscarinic receptor signaling pathway involved in activation of IKACH; muscarinic receptor signaling pathway involved in ion channel activation; positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling
Comment: This term was obsoleted because it represents a molecular function.
obsolete adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process (GO:0086096)
Namespace: biological_process
Definition: OBSOLETE. An adenylate cyclase-inhibiting adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
Synonyms: cardiac adrenergic receptor signaling pathway via inhibition of adenylate cyclase activity; G-inhibitory-coupled Beta2AR signaling pathway involved in heart process; Gi-coupled adrenergic receptor signaling pathway involved in heart process; Gi-coupled Beta2-AR signaling pathway involved in heart process
Comment: This term was obsoleted because it represents a GO-CAM pathway.
phospholipase C-activating angiotensin-activated signaling pathway (GO:0086097)
Namespace: biological_process
Definition: A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: angiotensin-mediated signaling pathway via activation of phospholipase C; Gq-coupled angiotensin receptor signaling pathway; phospholipase C-activating angiotensin receptor signaling pathway; phospholipase C-activating angiotensin-mediated signaling pathway; PLC-activating angiotensin receptor signaling pathway
angiotensin-activated signaling pathway involved in heart process (GO:0086098)
Namespace: biological_process
Definition: An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
Synonyms: angiotensin receptor signaling pathway involved in heart process; angiotensin receptor signalling pathway involved in heart process; angiotensin-mediated signaling pathway involved in heart process
obsolete phospholipase C-activating angiotensin-activated signaling pathway involved in heart process (GO:0086099)
Namespace: biological_process
Definition: OBSOLETE. An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.
Synonyms: angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process; cardiac angiotensin receptor signaling pathway via activation of PLC; Gq-coupled angiotensin receptor signaling pathway involved in heart process; phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process; PLC-activating angiotensin receptor signaling pathway involved in heart process
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
endothelin receptor signaling pathway (GO:0086100)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: endothelin signaling pathway
endothelin receptor signaling pathway involved in heart process (GO:0086101)
Namespace: biological_process
Definition: An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
Synonyms: endothelin receptor signalling pathway involved in heart process
obsolete adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086102)
Namespace: biological_process
Definition: OBSOLETE. An adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate.
Synonyms: AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate; G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity; Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate; muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current; muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel
Comment: This term was obsoleted because it represents a GO-CAM pathway.
G protein-coupled receptor signaling pathway involved in heart process (GO:0086103)
Namespace: biological_process
Definition: An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
Synonyms: G-protein coupled receptor signaling pathway involved in heart process; G-protein coupled receptor signalling pathway involved in heart process; GPCR signaling pathway involved in cardiac process; GPCR signaling pathway involved in heart process
obsolete protein kinase D signaling (GO:0089700)
Namespace: biological_process
Definition: OBSOLETE. A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound.
Synonyms: PKD signal transduction; PKD signaling cascade; protein kinase D signal transduction; protein kinase D signaling cascade; protein kinase D signalling cascade
Comment: This term was obsoleted because protein kinase D activity is part of other signaling pathways, it is not itself a signaling pathway.
U2AF complex (GO:0089701)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point.
Synonyms: U2 accessory factor; U2AF
undecaprenyl-phosphate glucose phosphotransferase activity (GO:0089702)
Namespace: molecular_function
Definition: Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP.
L-aspartate transmembrane export from vacuole (GO:0089703)
Namespace: biological_process
Definition: The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane.
L-glutamate transmembrane export from vacuole (GO:0089704)
Namespace: biological_process
Definition: The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane.
protein localization to outer membrane (GO:0089705)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane.
L-ornithine transmembrane export from vacuole (GO:0089706)
Namespace: biological_process
Definition: The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane.
L-lysine transmembrane export from vacuole (GO:0089707)
Namespace: biological_process
Definition: The directed movement of L-lysine out of the vacuole, across the vacuolar membrane.
L-histidine transmembrane export from vacuole (GO:0089708)
Namespace: biological_process
Definition: The directed movement of L-histidine out of the vacuole, across the vacuolar membrane.