LiteFold/GO huggingface dataset:
protein insertion into ER membrane by stop-transfer membrane-anchor sequence (GO:0045050)
Namespace: biological_process
Definition: A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
Synonyms: protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence; protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated; protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence; protein-ER insertion by stop-transfer membrane-anchor sequence; stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane
protein insertion into ER membrane by internal uncleaved signal-anchor sequence (GO:0045051)
Namespace: biological_process
Definition: A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences.
Synonyms: internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane; protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence; protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated; protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence; protein-ER insertion by internal uncleaved signal-anchor sequence
obsolete protein insertion into ER membrane by GPI attachment sequence (GO:0045052)
Namespace: biological_process
Definition: OBSOLETE. A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule.
Synonyms: GPI attachment sequence mediated protein insertion into ER membrane; protein insertion into endoplasmic reticulum membrane by GPI attachment sequence; protein insertion into ER membrane, GPI attachment sequence mediated; protein-endoplasmic reticulum insertion by GPI attachment sequence; protein-ER insertion by GPI attachment sequence
Comment: The reason for obsoletion is that this term was added in error.
protein retention in Golgi apparatus (GO:0045053)
Namespace: biological_process
Definition: The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.
Synonyms: maintenance of protein location in Golgi apparatus; protein-Golgi retention; retention of protein in Golgi
constitutive secretory pathway (GO:0045054)
Namespace: biological_process
Definition: A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space.
Synonyms: constitutive exocytosis
regulated exocytosis (GO:0045055)
Namespace: biological_process
Definition: A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
Synonyms: regulated secretory pathway
transcytosis (GO:0045056)
Namespace: biological_process
Definition: The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
cisternal progression (GO:0045057)
Namespace: biological_process
Definition: The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna.
Synonyms: cisternal maturation
positive thymic T cell selection (GO:0045059)
Namespace: biological_process
Definition: The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms: positive thymic T lymphocyte selection; positive thymic T-cell selection; positive thymic T-lymphocyte selection
thymic T cell selection (GO:0045061)
Namespace: biological_process
Definition: The process of T cell selection that occurs in the thymus.
Synonyms: thymic T lymphocyte selection; thymic T-cell selection; thymic T-lymphocyte selection
extrathymic T cell selection (GO:0045062)
Namespace: biological_process
Definition: The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus.
Synonyms: extrathymic T lymphocyte selection; extrathymic T-cell selection; extrathymic T-lymphocyte selection
T-helper 1 cell differentiation (GO:0045063)
Namespace: biological_process
Definition: The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
Synonyms: T-helper 1 cell development
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
T-helper 2 cell differentiation (GO:0045064)
Namespace: biological_process
Definition: The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4.
Synonyms: T-helper 2 cell development
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
cytotoxic T cell differentiation (GO:0045065)
Namespace: biological_process
Definition: The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.
Synonyms: cytotoxic T cell development; cytotoxic T lymphocyte selection; cytotoxic T-cell selection; cytotoxic T-lymphocyte selection
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
regulatory T cell differentiation (GO:0045066)
Namespace: biological_process
Definition: The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
Synonyms: regulatory T cell development; regulatory T lymphocyte differentiation; regulatory T-cell differentiation; regulatory T-lymphocyte differentiation; suppressor T cell differentiation; suppressor T lymphocyte differentiation; suppressor T-cell differentiation; suppressor T-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
negative extrathymic T cell selection (GO:0045068)
Namespace: biological_process
Definition: The process of elimination of extrathymically maturing T cells which react strongly with self-antigens.
Synonyms: negative extrathymic T lymphocyte selection; negative extrathymic T-cell selection; negative extrathymic T-lymphocyte selection
regulation of viral genome replication (GO:0045069)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of viral genome replication.
positive regulation of viral genome replication (GO:0045070)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of viral genome replication.
Synonyms: activation of viral genome replication; stimulation of viral genome replication; up regulation of viral genome replication; up-regulation of viral genome replication; upregulation of viral genome replication
negative regulation of viral genome replication (GO:0045071)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
Synonyms: down regulation of viral genome replication; down-regulation of viral genome replication; downregulation of viral genome replication; inhibition of viral genome replication
innate immune response (GO:0045087)
Namespace: biological_process
Definition: Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
Synonyms: innate immunity; nonspecific immune response
regulation of innate immune response (GO:0045088)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
positive regulation of innate immune response (GO:0045089)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
Synonyms: stimulation of innate immune response; up regulation of innate immune response; up-regulation of innate immune response; upregulation of innate immune response
regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.
Synonyms: regulation of retroviral genome replication
interleukin-18 receptor complex (GO:0045092)
Namespace: cellular_component
Definition: A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.
Synonyms: IL-18 receptor complex
obsolete interleukin-18 alpha subunit binding (GO:0045093)
Namespace: molecular_function
Definition: OBSOLETE. Binding to alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells.
Synonyms: IL-18Ra binding
Comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits
obsolete interleukin-18 beta subunit binding (GO:0045094)
Namespace: molecular_function
Definition: OBSOLETE. Binding to beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a.
Synonyms: IL-18Rb binding
Comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits.
keratin filament (GO:0045095)
Namespace: cellular_component
Definition: A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.
Synonyms: acidic keratin; basic/neutral keratin
obsolete acidic keratin (GO:0045096)
Namespace: cellular_component
Definition: OBSOLETE. A type of intermediate filament.
Synonyms: acidic keratin; type I intermediate filament
Comment: This term was made obsolete because it represents a gene product.
obsolete basic/neutral keratin (GO:0045097)
Namespace: cellular_component
Definition: OBSOLETE. A type of intermediate filament.
Synonyms: basic/neutral keratin; type II intermediate filament
Comment: This term was made obsolete because it represents a gene product.
type III intermediate filament (GO:0045098)
Namespace: cellular_component
Definition: A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.
Synonyms: desmin; glial fibrillary acidic protein; peripherin; type III intermediate filament associated protein; vimentin
obsolete vimentin (GO:0045099)
Namespace: cellular_component
Definition: OBSOLETE. A type of intermediate filament.
Synonyms: vimentin
Comment: This term was made obsolete because it represents a gene product.
obsolete desmin (GO:0045100)
Namespace: cellular_component
Definition: OBSOLETE. A type of intermediate filament.
Synonyms: desmin
Comment: This term was made obsolete because it represents a gene product.
obsolete glial fibrillary acidic protein (GO:0045101)
Namespace: cellular_component
Definition: OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes.
Synonyms: GFAP; glial fibrillary acidic protein
Comment: This term was made obsolete because it represents a gene product.
intermediate filament-based process (GO:0045103)
Namespace: biological_process
Definition: Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.
intermediate filament cytoskeleton organization (GO:0045104)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.
Synonyms: intermediate filament cytoskeleton organisation; intermediate filament cytoskeleton organization and biogenesis
intermediate filament polymerization or depolymerization (GO:0045105)
Namespace: biological_process
Definition: Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament.
intermediate filament polymerization (GO:0045107)
Namespace: biological_process
Definition: Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.
regulation of intermediate filament polymerization or depolymerization (GO:0045108)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases.
intermediate filament organization (GO:0045109)
Namespace: biological_process
Definition: Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
Synonyms: intermediate filament organisation
intermediate filament bundle assembly (GO:0045110)
Namespace: biological_process
Definition: The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.
Synonyms: tonofilament assembly
intermediate filament cytoskeleton (GO:0045111)
Namespace: cellular_component
Definition: Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
integrin biosynthetic process (GO:0045112)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules.
Synonyms: integrin anabolism; integrin biosynthesis; integrin formation; integrin synthesis
regulation of integrin biosynthetic process (GO:0045113)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.
Synonyms: regulation of integrin anabolism; regulation of integrin biosynthesis; regulation of integrin formation; regulation of integrin synthesis
beta 2 integrin biosynthetic process (GO:0045114)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit.
Synonyms: beta 2 integrin anabolism; beta 2 integrin biosynthesis; beta 2 integrin formation; beta 2 integrin synthesis
regulation of beta 2 integrin biosynthetic process (GO:0045115)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.
Synonyms: regulation of beta 2 integrin anabolism; regulation of beta 2 integrin biosynthesis; regulation of beta 2 integrin formation; regulation of beta 2 integrin synthesis
protein neddylation (GO:0045116)
Namespace: biological_process
Definition: Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
Synonyms: RUB1-protein conjugation
Comment: Note that currently, the only known substrates of neddylation are cullin family proteins.
azole transmembrane transport (GO:0045117)
Namespace: biological_process
Definition: The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane.
Synonyms: azole transport
azole:proton antiporter activity (GO:0045119)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances.
Synonyms: azole:hydrogen antiporter activity; bicyclomycin/sulfathiazole:hydrogen antiporter activity
pronucleus (GO:0045120)
Namespace: cellular_component
Definition: The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.
membrane raft (GO:0045121)
Namespace: cellular_component
Definition: Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
Synonyms: GEM domain; glycolipid-enriched membrane domain; lipid raft
aflatoxin biosynthetic process (GO:0045122)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms: aflatoxin anabolism; aflatoxin biosynthesis; aflatoxin formation; aflatoxin synthesis
cellular extravasation (GO:0045123)
Namespace: biological_process
Definition: The migration of a leukocyte from the blood vessels into the surrounding tissue.
Synonyms: immune cell cellular extravasation; leucocyte cellular extravasation; leukocyte cellular extravasation; transendothelial leukocyte migration
regulation of bone resorption (GO:0045124)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).
bioactive lipid receptor activity (GO:0045125)
Namespace: molecular_function
Definition: Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.
N-acetylglucosamine kinase activity (GO:0045127)
Namespace: molecular_function
Definition: Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + H+.
Synonyms: 2-acetylamino-2-deoxy-D-glucose kinase activity; acetylaminodeoxyglucokinase activity; acetylglucosamine kinase (phosphorylating); ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity; ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity; GlcNAc kinase activity
negative regulation of reciprocal meiotic recombination (GO:0045128)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
Synonyms: down regulation of meiotic recombination; down-regulation of meiotic recombination; downregulation of meiotic recombination; inhibition of meiotic recombination; suppression of meiotic recombination
obsolete NAD-independent histone deacetylase activity (GO:0045129)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone.
Synonyms: AcuC
Comment: This term was obsoleted because it represents the same activity as histone deacetylase activity, hydrolytic mechanism ; GO:0004407.
keratan sulfotransferase activity (GO:0045130)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.
Synonyms: 3'-phosphoadenylyl keratan sulfotransferase activity; 3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity; 3'-phosphoadenylylsulfate:keratan sulfotransferase activity; keratan sulfate Gal-6-sulfotransferase activity; keratan sulfate sulfotransferase activity; keratan sulphotransferase activity
pre-mRNA branch point binding (GO:0045131)
Namespace: molecular_function
Definition: Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site.
meiotic chromosome segregation (GO:0045132)
Namespace: biological_process
Definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.