LiteFold/GO huggingface dataset:
high-affinity basic amino acid transmembrane transporter activity (GO:0005287)
Namespace: molecular_function
Definition: Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity basic amino acid transmembrane transporter activity; high-affinity basic amino acid transporter activity
high-affinity L-arginine transmembrane transporter activity (GO:0005289)
Namespace: molecular_function
Definition: Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity arginine transmembrane transporter activity; high-affinity arginine transmembrane transporter activity; high-affinity arginine transporter activity
high-affinity L-histidine transmembrane transporter activity (GO:0005291)
Namespace: molecular_function
Definition: Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity histidine permease activity; high affinity L-histidine transmembrane transporter activity
high-affinity lysine transmembrane transporter activity (GO:0005292)
Namespace: molecular_function
Definition: Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity lysine transmembrane transporter activity; high affinity lysine transporter activity
neutral L-amino acid secondary active transmembrane transporter activity (GO:0005294)
Namespace: molecular_function
Definition: Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: neutral L-amino acid porter activity
neutral L-amino acid:sodium symporter activity (GO:0005295)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in).
Synonyms: neutral amino acid-sodium cotransporter; neutral amino acid:sodium symporter activity; sodium/neutral amino acid transporter
proline:proton symporter activity (GO:0005297)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in).
Synonyms: hydrogen/proline transporter
proline:sodium symporter activity (GO:0005298)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).
Synonyms: sodium/proline symporter activity
high-affinity tryptophan transmembrane transporter activity (GO:0005300)
Namespace: molecular_function
Definition: Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high-affinity tryptophan transporter activity
obsolete valine/tyrosine/tryptophan permease activity (GO:0005301)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: hydrogen/valine-tyrosine-tryptophan transporter; valine/tyrosine/tryptophan permease activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
L-tyrosine transmembrane transporter activity (GO:0005302)
Namespace: molecular_function
Definition: Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid.
Synonyms: L-tyrosine permease activity; L-tyrosine transporter activity; valine/tyrosine/tryptophan permease activity
L-valine transmembrane transporter activity (GO:0005304)
Namespace: molecular_function
Definition: Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid.
Synonyms: isoleucine/valine:sodium symporter activity; L-valine transporter activity; leucine/isoleucine/valine porter activity; leucine/valine/isoleucine permease activity; valine/tyrosine/tryptophan permease activity
choline:sodium symporter activity (GO:0005307)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
Synonyms: sodium/choline symporter activity
creatine transmembrane transporter activity (GO:0005308)
Namespace: molecular_function
Definition: Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
creatine:sodium symporter activity (GO:0005309)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in).
Synonyms: sodium/chloride-dependent creatine transporter
dicarboxylic acid transmembrane transporter activity (GO:0005310)
Namespace: molecular_function
Definition: Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups.
Synonyms: dicarboxylate (succinate/fumarate/malate) antiporter activity; dicarboxylate carrier; dicarboxylic acid permease activity; sodium:dicarboxylate/tricarboxylate symporter activity
obsolete sodium:dicarboxylate/tricarboxylate symporter activity (GO:0005311)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in).
Synonyms: sodium:dicarboxylate/tricarboxylate cotransporter activity; sodium:dicarboxylate/tricarboxylate symporter activity
Comment: This term was made obsolete because it represents a multifunctional gene product.
L-glutamate transmembrane transporter activity (GO:0005313)
Namespace: molecular_function
Definition: Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
Synonyms: glutamate transmembrane transporter activity; glutamate/aspartate porter activity; glutamate/aspartate:sodium symporter activity; L-glutamate transporter activity
phosphate transmembrane transporter activity (GO:0005315)
Namespace: molecular_function
Definition: Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: inorganic phosphate transmembrane transporter activity
high-affinity phosphate:sodium symporter activity (GO:0005316)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction:phosphate(out) + Na+(out) = phosphate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity inorganic phosphate:sodium symporter activity; high-affinity inorganic phosphate:sodium symporter activity; sodium/phosphate cotransporter activity
obsolete phosphate:hydrogen symporter (GO:0005318)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: phosphate:hydrogen symporter; phosphate:proton symporter activity
lipid carrier activity (GO:0005319)
Namespace: molecular_function
Definition: Directly binding to a specific lipid and delivering it either to an acceptor molecule or to a specific location.
Synonyms: apolipoprotein; lipid transporter activity; lipophorin
obsolete apolipoprotein (GO:0005320)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: apolipoprotein
Comment: This term was made obsolete because it does not represent a molecular function.
obsolete high-density lipoprotein (GO:0005321)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: HDL; high-density lipoprotein
Comment: This term was made obsolete because it does not represent a molecular function.
obsolete low-density lipoprotein (GO:0005322)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: LDL; low-density lipoprotein
Comment: This term was made obsolete because it does not represent a molecular function.
obsolete very-low-density lipoprotein (GO:0005323)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: very-low-density lipoprotein; VLDL
Comment: This term was made obsolete because it does not represent a molecular function.
long-chain fatty acid transmembrane transporter activity (GO:0005324)
Namespace: molecular_function
Definition: Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Synonyms: long-chain fatty acid transporter activity
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
neurotransmitter transmembrane transporter activity (GO:0005326)
Namespace: molecular_function
Definition: Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
Synonyms: neurotransmitter transporter activity
neurotransmitter:sodium symporter activity (GO:0005328)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in).
Synonyms: sodium/neurotransmitter symporter activity
dopamine:sodium symporter activity (GO:0005330)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in).
Synonyms: dopamine transmembrane transporter activity; dopamine:sodium:chloride symporter activity; sodium/dopamine symporter activity
gamma-aminobutyric acid:sodium:chloride symporter activity (GO:0005332)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in).
Synonyms: 4-aminobutanoate:sodium symporter activity; 4-aminobutyrate:sodium symporter activity; betaine/GABA:sodium symporter activity; GABA:sodium symporter activity; gamma-aminobutyric acid:sodium symporter activity; sodium/chloride-dependent GABA transporter activity
Comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'.
norepinephrine:sodium symporter activity (GO:0005334)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in).
Synonyms: levarterenol transporter activity; noradrenaline transporter activity; norepinephrine transmembrane transporter activity; norepinephrine:sodium:chloride symporter activity; sodium/norepinephrine symporter activity
serotonin:sodium:chloride symporter activity (GO:0005335)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in).
Synonyms: serotonin transmembrane transporter activity; serotonin:sodium symporter activity; sodium/serotonin symporter activity
nucleoside transmembrane transporter activity (GO:0005337)
Namespace: molecular_function
Definition: Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other.
Synonyms: intracellular nucleoside transmembrane transporter activity
nucleotide-sugar transmembrane transporter activity (GO:0005338)
Namespace: molecular_function
Definition: Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.
obsolete organic acid transmembrane transporter activity (GO:0005342)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage.
Comment: The reason for obsoletion is that this term was an unnecessary and confusing grouping term.
organic acid:sodium symporter activity (GO:0005343)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).
Synonyms: sodium/chloride-dependent organic acid cotransporter activity; sodium:dicarboxylate/tricarboxylate symporter activity
oxygen carrier activity (GO:0005344)
Namespace: molecular_function
Definition: Binding to oxygen and delivering it to an acceptor molecule or a specific location.
Synonyms: globin; hemerythrin; hemocyanin; oxygen-carrying
purine nucleobase transmembrane transporter activity (GO:0005345)
Namespace: molecular_function
Definition: Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other.
Synonyms: purine base transmembrane transporter activity; purine transmembrane transporter activity
purine ribonucleotide transmembrane transporter activity (GO:0005346)
Namespace: molecular_function
Definition: Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other.
pyrimidine nucleobase transmembrane transporter activity (GO:0005350)
Namespace: molecular_function
Definition: Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other.
Synonyms: pyrimidine base transmembrane transporter activity; pyrimidine transmembrane transporter activity
alpha-glucoside:proton symporter activity (GO:0005352)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.
Synonyms: alpha-glucoside:hydrogen symporter activity; general alpha-glucoside transporter activity; general alpha-glucoside:hydrogen symporter activity; general alpha-glucoside:proton symporter activity
fructose transmembrane transporter activity (GO:0005353)
Namespace: molecular_function
Definition: Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
Synonyms: fructose permease activity; fructose porter activity
galactose transmembrane transporter activity (GO:0005354)
Namespace: molecular_function
Definition: Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
Synonyms: galactose/glucose (methylgalactoside) porter activity
obsolete glucose transmembrane transporter activity (GO:0005355)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
Synonyms: galactose/glucose (methylgalactoside) porter activity; glucose permease activity; glucose transmembrane transporter activity; lactose/glucose efflux transporter activity
Comment: This term was obsoleted because it represents the same reaction as D-glucose transmembrane transporter activity ; GO:0055056.
D-glucose:proton symporter activity (GO:0005356)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
Synonyms: glucose:proton symporter activity; hydrogen:glucose symporter activity; hydrogen:glucose transporter activity; transepithelial hydrogen/glucose transporter activity; transepithelial hydrogen:glucose symporter activity; transepithelial hydrogen:glucose transporter activity
obsolete constitutive glucose:proton symporter activity (GO:0005357)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
Synonyms: constitutive hydrogen/glucose transporter activity; constitutive hydrogen:glucose symporter activity; constitutive hydrogen:glucose transporter activity
Comment: The reason for obsoletion is that the constitutive aspect of the transporter is unlikely to be an aspect of the activity, but instead it probably relates to the expression level of the transporter.
high-affinity D-glucose:proton symporter activity (GO:0005358)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high-affinity glucose:proton symporter activity; high-affinity hydrogen/glucose transporter activity; high-affinity hydrogen:glucose symporter activity; high-affinity hydrogen:glucose transporter activity
low-affinity D-glucose:proton symporter activity (GO:0005359)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
Synonyms: low-affinity glucose:proton symporter activity; low-affinity hydrogen/glucose transporter activity; low-affinity hydrogen:glucose symporter activity; low-affinity hydrogen:glucose transporter activity
insulin-responsive D-glucose:proton symporter activity (GO:0005360)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
Synonyms: insulin-responsive glucose:proton symporter activity; insulin-responsive hydrogen:glucose symporter activity; insulin-responsive hydrogen:glucose transporter activity; transepithelial hydrogen/glucose transporter activity
low-affinity D-glucose:sodium symporter activity (GO:0005362)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
Synonyms: low-affinity glucose-sodium cotransporter activity; low-affinity glucose:sodium symporter activity
maltose:proton symporter activity (GO:0005364)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in).
Synonyms: hydrogen/maltose transporter activity; maltose permease; maltose:hydrogen symporter activity
myo-inositol transmembrane transporter activity (GO:0005365)
Namespace: molecular_function
Definition: Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.
Synonyms: vitamin Bh transporter activity
myo-inositol:proton symporter activity (GO:0005366)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in).
Synonyms: hydrogen/myo-inositol transporter activity; myo-inositol:hydrogen symporter activity
myo-inositol:sodium symporter activity (GO:0005367)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in).
Synonyms: myo-inositol-sodium cotransporter activity