LiteFold/GO huggingface dataset:
obsolete positive regulation of thymidylate synthase biosynthetic process (GO:0050759)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase.
Synonyms: activation of thymidylate synthase biosynthetic process; positive regulation of thymidylate synthase anabolism; positive regulation of thymidylate synthase biosynthesis; positive regulation of thymidylate synthase formation; positive regulation of thymidylate synthase synthesis; stimulation of thymidylate synthase biosynthetic process; up regulation of thymidylate synthase biosynthetic process; up-regulation of thymidylate synthase biosynthetic process; upregulation of thymidylate synthase biosynthetic process
Comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'positive regulation of gene expression', 'positive regulation of transcription' or some signaling term.
depsipeptide metabolic process (GO:0050761)
Namespace: biological_process
Definition: The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.
Synonyms: depsipeptide metabolism
depsipeptide catabolic process (GO:0050762)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.
Synonyms: depsipeptide breakdown; depsipeptide catabolism; depsipeptide degradation
depsipeptide biosynthetic process (GO:0050763)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.
Synonyms: depsipeptide anabolism; depsipeptide biosynthesis; depsipeptide formation; depsipeptide synthesis
regulation of phagocytosis (GO:0050764)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
negative regulation of phagocytosis (GO:0050765)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
Synonyms: down regulation of phagocytosis; down-regulation of phagocytosis; downregulation of phagocytosis; inhibition of phagocytosis
positive regulation of phagocytosis (GO:0050766)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of phagocytosis.
Synonyms: activation of phagocytosis; stimulation of phagocytosis; up regulation of phagocytosis; up-regulation of phagocytosis; upregulation of phagocytosis
regulation of neurogenesis (GO:0050767)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
positive regulation of neurogenesis (GO:0050769)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
Synonyms: activation of neurogenesis; stimulation of neurogenesis; up regulation of neurogenesis; up-regulation of neurogenesis; upregulation of neurogenesis
regulation of axonogenesis (GO:0050770)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
negative regulation of axonogenesis (GO:0050771)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
Synonyms: down regulation of axonogenesis; down-regulation of axonogenesis; downregulation of axonogenesis; inhibition of axonogenesis
positive regulation of axonogenesis (GO:0050772)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of axonogenesis.
Synonyms: activation of axonogenesis; stimulation of axonogenesis; up regulation of axonogenesis; up-regulation of axonogenesis; upregulation of axonogenesis
regulation of dendrite development (GO:0050773)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of dendrite development.
negative regulation of dendrite morphogenesis (GO:0050774)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.
Synonyms: down regulation of dendrite morphogenesis; down-regulation of dendrite morphogenesis; downregulation of dendrite morphogenesis; inhibition of dendrite morphogenesis
positive regulation of dendrite morphogenesis (GO:0050775)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
Synonyms: activation of dendrite morphogenesis; stimulation of dendrite morphogenesis; up regulation of dendrite morphogenesis; up-regulation of dendrite morphogenesis; upregulation of dendrite morphogenesis
regulation of immune response (GO:0050776)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
negative regulation of immune response (GO:0050777)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
Synonyms: down regulation of immune response; down-regulation of immune response; downregulation of immune response; inhibition of immune response
positive regulation of immune response (GO:0050778)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
Synonyms: stimulation of immune response; up regulation of immune response; up-regulation of immune response; upregulation of immune response
RNA destabilization (GO:0050779)
Namespace: biological_process
Definition: Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes.
ortho-trichlorophenol reductive dehalogenase activity (GO:0050781)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl.
Synonyms: 2,4,6-TCP reductive dehalogenase activity; 2,4,6-trichlorophenol reductive dehalogenase activity
galactose uniporter activity (GO:0050782)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in).
Synonyms: galactose, glucose uniporter activity
cocaine catabolic process (GO:0050784)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic.
Synonyms: cocaine breakdown; cocaine catabolism; cocaine degradation
advanced glycation end-product receptor activity (GO:0050785)
Namespace: molecular_function
Definition: Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins).
Synonyms: AGE receptor activity; RAGE activity
RAGE receptor binding (GO:0050786)
Namespace: molecular_function
Definition: Binding to a RAGE receptor, the receptor for advanced glycation end-products.
Synonyms: advanced glycation end-product receptor binding
detoxification of mercury ion (GO:0050787)
Namespace: biological_process
Definition: Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0]).
obsolete sequestering of mercury (GO:0050788)
Namespace: biological_process
Definition: OBSOLETE. The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system.
Synonyms: mercuric ion (Hg2+) sequestering; mercuric ion (Hg2+) sequestration; mercury (Hg) ion sequestering; mercury (Hg) ion sequestration; mercury (Hg2+) ion retention; mercury (Hg2+) ion storage; retention of mercury (Hg2+) ion; sequestering of mercuric ion (Hg2+); sequestering of mercury (Hg) ion; sequestration of mercuric ion (Hg2+); sequestration of mercury (Hg) ion; storage of mercury (Hg2+) ion
Comment: The reason for obsoletion is that this term represents a molecular function, not a biological process.
regulation of catalytic activity (GO:0050790)
Namespace: biological_process
Definition: Any process that modulates the activity of an enzyme.
Synonyms: regulation of enzyme activity; regulation of metalloenzyme activity
regulation of viral process (GO:0050792)
Namespace: biological_process
Definition: Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts.
Synonyms: regulation of viral reproduction
regulation of developmental process (GO:0050793)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of insulin secretion (GO:0050796)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the regulated release of insulin.
activated T cell proliferation (GO:0050798)
Namespace: biological_process
Definition: The expansion of a T cell population following activation by an antigenic stimulus.
Synonyms: activated T lymphocyte proliferation; activated T-cell proliferation; activated T-lymphocyte proliferation; proliferation of activated T cells
Comment: Note that this term refers to the proliferation of previously activated T cells; it is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells.
cocaine biosynthetic process (GO:0050799)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic.
Synonyms: cocaine anabolism; cocaine biosynthesis; cocaine formation; cocaine synthesis
obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement (GO:0050800)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance.
Synonyms: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
Comment: This term was made obsolete because it represents both process and function information.
monoatomic ion homeostasis (GO:0050801)
Namespace: biological_process
Definition: Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
Synonyms: electrolyte homeostasis; ion homeostasis; negative regulation of crystal formation; regulation of ion homeostasis
circadian sleep/wake cycle, sleep (GO:0050802)
Namespace: biological_process
Definition: The part of the circadian sleep/wake cycle where the organism is asleep.
regulation of synapse structure or activity (GO:0050803)
Namespace: biological_process
Definition: Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
modulation of chemical synaptic transmission (GO:0050804)
Namespace: biological_process
Definition: Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
Synonyms: modulation of synaptic transmission; regulation of chemical synaptic transmission; regulation of synaptic transmission
negative regulation of synaptic transmission (GO:0050805)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
Synonyms: down regulation of synaptic transmission; down-regulation of synaptic transmission; downregulation of synaptic transmission; inhibition of synaptic transmission
positive regulation of synaptic transmission (GO:0050806)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
Synonyms: activation of synaptic transmission; stimulation of synaptic transmission; up regulation of synaptic transmission; up-regulation of synaptic transmission; upregulation of synaptic transmission
regulation of synapse organization (GO:0050807)
Namespace: biological_process
Definition: Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
Synonyms: regulation of synapse organisation; regulation of synapse organization and biogenesis; regulation of synapse structure
synapse organization (GO:0050808)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
Synonyms: synapse development; synapse morphogenesis; synapse organisation; synapse organization and biogenesis
diazepam binding (GO:0050809)
Namespace: molecular_function
Definition: Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium.
Synonyms: diazepam binding inhibitor activity; Valium binding
regulation of steroid biosynthetic process (GO:0050810)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
Synonyms: regulation of steroid anabolism; regulation of steroid biosynthesis; regulation of steroid formation; regulation of steroid synthesis; regulation of steroidogenesis
GABA receptor binding (GO:0050811)
Namespace: molecular_function
Definition: Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
Synonyms: 4-aminobutanoate receptor binding; 4-aminobutyrate receptor binding; diazepam binding inhibitor activity; gamma-aminobutyric acid receptor binding
regulation of acyl-CoA biosynthetic process (GO:0050812)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.
Synonyms: regulation of acyl-CoA anabolism; regulation of acyl-CoA biosynthesis; regulation of acyl-CoA formation; regulation of acyl-CoA synthesis
obsolete epothilone metabolic process (GO:0050813)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer.
Synonyms: epothilone metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
epothilone biosynthetic process (GO:0050814)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer.
Synonyms: epothilone anabolism; epothilone biosynthesis; epothilone formation; epothilone synthesis
phosphoserine residue binding (GO:0050815)
Namespace: molecular_function
Definition: Binding to a phosphorylated serine residue within a protein.
Synonyms: phosphoserine binding
phosphothreonine residue binding (GO:0050816)
Namespace: molecular_function
Definition: Binding to a phosphorylated threonine residue within a protein.
Synonyms: phosphothreonine binding
coagulation (GO:0050817)
Namespace: biological_process
Definition: The process in which a fluid solution, or part of it, changes into a solid or semisolid mass.
Synonyms: clotting
regulation of coagulation (GO:0050818)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass.
Synonyms: regulation of clotting
negative regulation of coagulation (GO:0050819)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.
Synonyms: anticoagulant activity; down regulation of coagulation; down-regulation of coagulation; downregulation of coagulation; inhibition of coagulation; negative regulation of clotting
protein stabilization (GO:0050821)
Namespace: biological_process
Definition: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
Synonyms: lysosomal protein stabilization; positive regulation of protein stability; protein sequestering; protein stabilisation; protein stabilization activity
peptide stabilization (GO:0050822)
Namespace: biological_process
Definition: Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded.
Synonyms: peptide stabilisation; peptide stabilization activity
obsolete water binding (GO:0050824)
Namespace: molecular_function
Definition: OBSOLETE. Binding to water (H2O).
Comment: This term was obsoleted because water binding is non-specific.
ice binding (GO:0050825)
Namespace: molecular_function
Definition: Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal.
Synonyms: ice crystal binding; ice nucleation inhibitor activity
response to freezing (GO:0050826)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius.
Synonyms: antifreeze activity; ice nucleation inhibitor activity
defense response to Gram-negative bacterium (GO:0050829)
Namespace: biological_process
Definition: Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
Synonyms: defence response to Gram-negative bacteria; defence response to Gram-negative bacterium; defense response to Gram-negative bacteria; Gram-negative antibacterial peptide activity
defense response to Gram-positive bacterium (GO:0050830)
Namespace: biological_process
Definition: Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
Synonyms: defence response to Gram-positive bacteria; defence response to Gram-positive bacterium; defense response to Gram-positive bacteria; Gram-positive antibacterial peptide activity
male-specific defense response to bacterium (GO:0050831)
Namespace: biological_process
Definition: A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism.
Synonyms: male-specific antibacterial peptide activity; male-specific defence response to bacteria; male-specific defence response to bacterium; male-specific defense response to bacteria
defense response to fungus (GO:0050832)
Namespace: biological_process
Definition: Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
Synonyms: defence response to fungi; defence response to fungus; defense response to fungi; defense response to fungus, incompatible interaction; resistance response to pathogenic fungi; resistance response to pathogenic fungus; response to parasitic fungi; response to parasitic fungus
pyruvate transmembrane transporter activity (GO:0050833)
Namespace: molecular_function
Definition: Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other.
Synonyms: monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
obsolete molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide (GO:0050834)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide.
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide (GO:0050835)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide.
Comment: This term was obsoleted because it represents a molecular function.
obsolete iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide (GO:0050836)
Namespace: biological_process
Definition: OBSOLETE. The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide.
Comment: This term was obsoleted because it represents a molecular function.
obsolete peptide cross-linking via L-cysteinyl-L-selenocysteine (GO:0050837)
Namespace: biological_process
Definition: OBSOLETE. The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P.
Comment: This term was obsoleted because it represents a reaction intermediate, not a biological process.
cell adhesion molecule binding (GO:0050839)
Namespace: molecular_function
Definition: Binding to a cell adhesion molecule.
Synonyms: adhesive extracellular matrix constituent; CAM binding; cell adhesion molecule activity; cell adhesion receptor activity
extracellular matrix binding (GO:0050840)
Namespace: molecular_function
Definition: Binding to a component of the extracellular matrix.
Synonyms: adhesive extracellular matrix constituent; extracellular matrix constituent binding
obsolete peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine (GO:0050841)
Namespace: biological_process
Definition: OBSOLETE. The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine.
Synonyms: peptidyl trimethyl lysine hydroxylase activity; peptidyl-trimethyl-lysine hydroxylase activity
Comment: This term was obsoleted because it represents a molecular function.