LiteFold/GO huggingface dataset:
beta-alanyl-histamine hydrolase activity (GO:0031964)
Namespace: molecular_function
Definition: Catalysis of the reaction: carcinine + H2O = histamine + beta-alanine. Carcinine is also known as N-beta-alanyl histamine.
Synonyms: carcinine hydrolase activity
nuclear membrane (GO:0031965)
Namespace: cellular_component
Definition: Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
mitochondrial membrane (GO:0031966)
Namespace: cellular_component
Definition: Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
organelle envelope (GO:0031967)
Namespace: cellular_component
Definition: A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
organelle outer membrane (GO:0031968)
Namespace: cellular_component
Definition: The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.
chloroplast membrane (GO:0031969)
Namespace: cellular_component
Definition: Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope.
chloroplast intermembrane space (GO:0031972)
Namespace: cellular_component
Definition: The region between the inner and outer lipid bilayers of a chloroplast envelope.
Synonyms: chloroplast envelope lumen
chromoplast intermembrane space (GO:0031973)
Namespace: cellular_component
Definition: The region between the inner and outer lipid bilayers of a chromoplast envelope.
Synonyms: chromoplast envelope lumen
membrane-enclosed lumen (GO:0031974)
Namespace: cellular_component
Definition: The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
obsolete envelope (GO:0031975)
Namespace: cellular_component
Definition: OBSOLETE. A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
Comment: The reason for obsoletion is that it is an unnecessary (and confusing) grouping term: mixes cell envelope and organelle envelopes.
plastid thylakoid (GO:0031976)
Namespace: cellular_component
Definition: Any thylakoid within a plastid.
thylakoid lumen (GO:0031977)
Namespace: cellular_component
Definition: The volume enclosed by a thylakoid membrane.
plastid thylakoid lumen (GO:0031978)
Namespace: cellular_component
Definition: The volume enclosed by a plastid thylakoid membrane.
plasma membrane-derived thylakoid lumen (GO:0031979)
Namespace: cellular_component
Definition: The volume enclosed by a plasma membrane-derived thylakoid.
Synonyms: plasma membrane thylakoid lumen
nuclear lumen (GO:0031981)
Namespace: cellular_component
Definition: The volume enclosed by the nuclear inner membrane.
vesicle (GO:0031982)
Namespace: cellular_component
Definition: Any small, fluid-filled, spherical organelle enclosed by membrane.
Synonyms: membrane-bounded vesicle; membrane-enclosed vesicle
vesicle lumen (GO:0031983)
Namespace: cellular_component
Definition: The volume enclosed by the membrane or protein that forms a vesicle.
organelle subcompartment (GO:0031984)
Namespace: cellular_component
Definition: A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle.
Synonyms: suborganelle compartment
Comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles.
Golgi cisterna (GO:0031985)
Namespace: cellular_component
Definition: Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.
Synonyms: Golgi apparatus cisterna; Golgi lamellae
proteinoplast (GO:0031986)
Namespace: cellular_component
Definition: A leucoplast in which protein is stored.
locomotion involved in locomotory behavior (GO:0031987)
Namespace: biological_process
Definition: Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
Synonyms: locomotion during locomotory behaviour
bombesin receptor signaling pathway (GO:0031989)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: bombesin receptor signalling pathway
mRNA export from nucleus in response to heat stress (GO:0031990)
Namespace: biological_process
Definition: The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export.
Synonyms: mRNA export from cell nucleus during heat stress; mRNA export from nucleus during heat stress
regulation of actomyosin contractile ring contraction (GO:0031991)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle.
Synonyms: regulation of actomyosin contractile ring constriction; regulation of contractile ring contraction involved in cell cycle cytokinesis; regulation of contractile ring contraction involved in cytokinesis during cell cycle
light transducer activity (GO:0031993)
Namespace: molecular_function
Definition: Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell.
insulin-like growth factor I binding (GO:0031994)
Namespace: molecular_function
Definition: Binding to insulin-like growth factor I.
Synonyms: IGF-I binding
insulin-like growth factor II binding (GO:0031995)
Namespace: molecular_function
Definition: Binding to insulin-like growth factor II.
Synonyms: IGF-II binding
thioesterase binding (GO:0031996)
Namespace: molecular_function
Definition: Binding to a thioesterase.
Synonyms: thiolesterase binding
regulation of fatty acid beta-oxidation (GO:0031998)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.
negative regulation of fatty acid beta-oxidation (GO:0031999)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.
Synonyms: down regulation of fatty acid beta-oxidation; down-regulation of fatty acid beta-oxidation; downregulation of fatty acid beta-oxidation; inhibition of fatty acid beta-oxidation
positive regulation of fatty acid beta-oxidation (GO:0032000)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.
Synonyms: activation of fatty acid beta-oxidation; stimulation of fatty acid beta-oxidation; up regulation of fatty acid beta-oxidation; up-regulation of fatty acid beta-oxidation; upregulation of fatty acid beta-oxidation
1,4-alpha-glucan 6-alpha-glucosyltransferase activity (GO:0032001)
Namespace: molecular_function
Definition: Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan.
Synonyms: 1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity; 1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity; D-glucosyltransferase; oligoglucan-branching glycosyltransferase activity; T-enzyme
interleukin-28 receptor complex (GO:0032002)
Namespace: cellular_component
Definition: A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1).
Synonyms: IL-28 receptor complex
interleukin-28 receptor binding (GO:0032003)
Namespace: molecular_function
Definition: Binding to an interleukin-28 receptor.
Synonyms: IL-28; interleukin-28 receptor ligand
signal transduction involved in positive regulation of conjugation with cellular fusion (GO:0032005)
Namespace: biological_process
Definition: The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion.
regulation of TOR signaling (GO:0032006)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of TOR signaling.
Synonyms: regulation of target of rapamycin signaling pathway; regulation of target of rapamycin signalling pathway; regulation of TOR signaling cascade; regulation of TOR signaling pathway; regulation of TOR signalling pathway
negative regulation of TOR signaling (GO:0032007)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
Synonyms: down regulation of TOR signaling pathway; down-regulation of TOR signaling pathway; downregulation of TOR signaling pathway; inhibition of TOR signaling pathway; negative regulation of target of rapamycin signaling pathway; negative regulation of target of rapamycin signalling pathway; negative regulation of TOR signaling cascade; negative regulation of TOR signaling pathway; negative regulation of TOR signalling pathway
positive regulation of TOR signaling (GO:0032008)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of TOR signaling.
Synonyms: activation of TOR signaling pathway; positive regulation of target of rapamycin signaling pathway; positive regulation of target of rapamycin signalling pathway; positive regulation of TOR signaling cascade; positive regulation of TOR signaling pathway; positive regulation of TOR signalling pathway; stimulation of TOR signaling pathway; up regulation of TOR signaling pathway; up-regulation of TOR signaling pathway; upregulation of TOR signaling pathway
early phagosome (GO:0032009)
Namespace: cellular_component
Definition: A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
Synonyms: early phagocytic vesicle
phagolysosome (GO:0032010)
Namespace: cellular_component
Definition: A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.
Synonyms: late phagocytic vesicle; late phagosome
ARF protein signal transduction (GO:0032011)
Namespace: biological_process
Definition: An intracellular signaling cassette in which a small monomeric GTPase of the ARF subfamily relays a signal.
regulation of ARF protein signal transduction (GO:0032012)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of ARF protein signal transduction.
negative regulation of ARF protein signal transduction (GO:0032013)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction.
Synonyms: down regulation of ARF protein signal transduction; down-regulation of ARF protein signal transduction; downregulation of ARF protein signal transduction; inhibition of ARF protein signal transduction
positive regulation of ARF protein signal transduction (GO:0032014)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.
Synonyms: activation of ARF protein signal transduction; stimulation of ARF protein signal transduction; up regulation of ARF protein signal transduction; up-regulation of ARF protein signal transduction; upregulation of ARF protein signal transduction
obsolete regulation of Ran protein signal transduction (GO:0032015)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of Ran protein signal transduction.
Comment: This term was obsoleted because this process is not known to be regulated.
obsolete negative regulation of Ran protein signal transduction (GO:0032016)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction.
Synonyms: down regulation of Ran protein signal transduction; down-regulation of Ran protein signal transduction; downregulation of Ran protein signal transduction; inhibition of Ran protein signal transduction
Comment: This term was obsoleted because this process is not known to be regulated.
obsolete positive regulation of Ran protein signal transduction (GO:0032017)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction.
Synonyms: activation of Ran protein signal transduction; stimulation of Ran protein signal transduction; up regulation of Ran protein signal transduction; up-regulation of Ran protein signal transduction; upregulation of Ran protein signal transduction
Comment: This term was obsoleted because this process is not known to be regulated.
2-methylbutanal reductase (NADPH) activity (GO:0032018)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-methylbutan-1-ol + NADP+ = 2-methylbutanal + NADPH + H+.
Synonyms: 2-methylbutanal reductase (NADP) activity; 2-methylbutanol:NADP oxidoreductase activity; 2-methylbutyraldehyde reductase (NADP) activity
mitochondrial cloud (GO:0032019)
Namespace: cellular_component
Definition: A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material.
Synonyms: Balbiani body; mitochondrial aggregate
ISG15-protein conjugation (GO:0032020)
Namespace: biological_process
Definition: The covalent addition to a protein of ISG15, a ubiquitin-like protein.
trypsinogen activation (GO:0032023)
Namespace: biological_process
Definition: The proteolytic processing of trypsinogen to the active form, trypsin.
Synonyms: cleavage of trypsinogen to trypsin
positive regulation of insulin secretion (GO:0032024)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
Synonyms: activation of insulin secretion; stimulation of insulin secretion; up regulation of insulin secretion; up-regulation of insulin secretion; upregulation of insulin secretion
response to cobalt ion (GO:0032025)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion (Co2+) stimulus.
response to magnesium ion (GO:0032026)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
myosin light chain binding (GO:0032027)
Namespace: molecular_function
Definition: Binding to a light chain of a myosin complex.
myosin head/neck binding (GO:0032028)
Namespace: molecular_function
Definition: Binding to the head/neck region of a myosin heavy chain.
myosin tail binding (GO:0032029)
Namespace: molecular_function
Definition: Binding to the tail region of a myosin heavy chain.
myosin I light chain binding (GO:0032030)
Namespace: molecular_function
Definition: Binding to a light chain of a myosin I complex.
myosin I tail binding (GO:0032032)
Namespace: molecular_function
Definition: Binding to the tail region of a myosin I heavy chain.
myosin II light chain binding (GO:0032033)
Namespace: molecular_function
Definition: Binding to a light chain of a myosin II complex.
myosin II head/neck binding (GO:0032034)
Namespace: molecular_function
Definition: Binding to the head/neck region of a myosin II heavy chain.
myosin I heavy chain binding (GO:0032037)
Namespace: molecular_function
Definition: Binding to a heavy chain of a myosin I complex.
myosin II heavy chain binding (GO:0032038)
Namespace: molecular_function
Definition: Binding to a heavy chain of a myosin II complex.
integrator complex (GO:0032039)
Namespace: cellular_component
Definition: A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.
small-subunit processome (GO:0032040)
Namespace: cellular_component
Definition: A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
Synonyms: small subunit processome; SSU processome
histone H3K14 deacetylase activity, NAD-dependent (GO:0032041)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K14 to NAD, producing nicotinamide.
Synonyms: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone H3-K14 deacetylase activity; NAD-dependent histone H3K14 deacetylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
mitochondrial DNA metabolic process (GO:0032042)
Namespace: biological_process
Definition: The chemical reactions and pathways involving mitochondrial DNA.
Synonyms: mitochondrial DNA metabolism; mtDNA metabolic process; mtDNA metabolism
DSIF complex (GO:0032044)
Namespace: cellular_component
Definition: A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
Synonyms: 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex; DRB sensitivity inducing factor complex; Spt4-Spt5 complex; Spt5-Spt4 complex
guanyl-nucleotide exchange factor complex (GO:0032045)
Namespace: cellular_component
Definition: A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
Synonyms: guanine nucleotide exchange factor
micropexophagy-specific membrane apparatus (GO:0032046)
Namespace: cellular_component
Definition: A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole.
Synonyms: micropexophagic apparatus; MIPA
mitosome (GO:0032047)
Namespace: cellular_component
Definition: A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria.
Synonyms: crypton
Comment: In Giardia species, mitosomes are sometimes present between the two nuclei.
cardiolipin metabolic process (GO:0032048)
Namespace: biological_process
Definition: The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
Synonyms: cardiolipin metabolism; diphosphatidylglycerol metabolic process; diphosphatidylglycerol metabolism
clathrin heavy chain binding (GO:0032050)
Namespace: molecular_function
Definition: Binding to a clathrin heavy chain.
clathrin light chain binding (GO:0032051)
Namespace: molecular_function
Definition: Binding to a clathrin light chain.
bile acid binding (GO:0032052)
Namespace: molecular_function
Definition: Binding to a bile acid, a steroid carboxylic acids occurring in bile.
ciliary basal body organization (GO:0032053)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum).
Synonyms: microtubule basal body organisation; microtubule basal body organization; microtubule basal body organization and biogenesis
negative regulation of translation in response to stress (GO:0032055)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.
Synonyms: down regulation of translation in response to stress; down-regulation of translation in response to stress; downregulation of translation in response to stress; inhibition of translation in response to stress
positive regulation of translation in response to stress (GO:0032056)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.
Synonyms: activation of translation in response to stress; stimulation of translation in response to stress; up regulation of translation in response to stress; up-regulation of translation in response to stress; upregulation of translation in response to stress
negative regulation of translational initiation in response to stress (GO:0032057)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.
Synonyms: down regulation of translation initiation in response to stress; down-regulation of translation initiation in response to stress; downregulation of translation initiation in response to stress; inhibition of translation initiation in response to stress
positive regulation of translational initiation in response to stress (GO:0032058)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.
Synonyms: activation of translation initiation in response to stress; stimulation of translation initiation in response to stress; up regulation of translation initiation in response to stress; up-regulation of translation initiation in response to stress; upregulation of translation initiation in response to stress
bleb (GO:0032059)
Namespace: cellular_component
Definition: A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
Synonyms: plasma membrane bleb