LiteFold/GO huggingface dataset:
detection of chemical stimulus involved in sensory perception of sour taste (GO:0001581)
Namespace: biological_process
Definition: The series of events required for a sour taste stimulus to be received and converted to a molecular signal.
Synonyms: perception of sour taste, detection of chemical stimulus; perception of sour taste, sensory transduction of chemical stimulus; sensory detection of chemical stimulus during perception of sour taste; sensory detection of sour taste; sensory transduction of chemical stimulus during perception of sour taste; sensory transduction of sour taste; sour taste detection
detection of chemical stimulus involved in sensory perception of sweet taste (GO:0001582)
Namespace: biological_process
Definition: The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
Synonyms: perception of sweet taste, detection of chemical stimulus; perception of sweet taste, sensory transduction of chemical stimulus; sensory detection of chemical stimulus during perception of sweet taste; sensory detection of sweet taste; sensory transduction of chemical stimulus during perception of sweet taste; sensory transduction of sweet taste; sweet taste detection
obsolete detection of chemical stimulus involved in sensory perception of salty taste (GO:0001583)
Namespace: biological_process
Definition: OBSOLETE. The series of events required for a salty taste stimulus to be received and converted to a molecular signal.
Synonyms: perception of salty taste, detection of chemical stimulus; perception of salty taste, sensory transduction of chemical stimulus; salty taste detection; sensory detection of chemical stimulus during perception of salty taste; sensory detection of salty taste; sensory transduction of chemical stimulus during perception of salty taste; sensory transduction of salty taste
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete rhodopsin-like receptor activity (GO:0001584)
Namespace: molecular_function
Definition: OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor.
Synonyms: Class A G protein coupled receptor; Class A G-protein coupled receptor; Class A GPCR; class A orphan receptor activity; rhodopsin-like receptor activity
Comment: This term was made obsolete because it represents a gene product and is named based on protein features.
Gi/o-coupled serotonin receptor activity (GO:0001586)
Namespace: molecular_function
Definition: Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.
Synonyms: 5-HT1 receptor activity; serotonin receptor activity, coupled via Gi/o
Gq/11-coupled serotonin receptor activity (GO:0001587)
Namespace: molecular_function
Definition: Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
Synonyms: 5-HT2 receptor activity; serotonin receptor activity, coupled via Gq/11
dopamine neurotransmitter receptor activity, coupled via Gs (GO:0001588)
Namespace: molecular_function
Definition: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
Synonyms: dopamine D1 receptor activity; dopamine D5 receptor activity
dopamine neurotransmitter receptor activity, coupled via Gi/Go (GO:0001591)
Namespace: molecular_function
Definition: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
Synonyms: dopamine D2 receptor activity; dopamine D3 receptor activity; dopamine D4 receptor activity
trace-amine receptor activity (GO:0001594)
Namespace: molecular_function
Definition: Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.
angiotensin type I receptor activity (GO:0001596)
Namespace: molecular_function
Definition: An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.
Synonyms: PLC-activating angiotensin receptor activity
obsolete apelin-like receptor (GO:0001597)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: apelin-like receptor; APJ-like receptor
Comment: This term was made obsolete because the function it represents does not exist.
obsolete chemokine receptor-like receptor activity (GO:0001598)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: chemokine receptor-like receptor activity
Comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
peptide YY receptor activity (GO:0001601)
Namespace: molecular_function
Definition: Combining with gut peptide YY to initiate a change in cell activity.
pancreatic polypeptide receptor activity (GO:0001602)
Namespace: molecular_function
Definition: Combining with pancreatic polypeptide PP to initiate a change in cell activity.
obsolete vasopressin-like receptor activity (GO:0001603)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: vasopressin-like receptor activity
urotensin II receptor activity (GO:0001604)
Namespace: molecular_function
Definition: Combining with urotensin II to initiate a change in cell activity.
adrenomedullin receptor activity (GO:0001605)
Namespace: molecular_function
Definition: Combining with adrenomedullin to initiate a change in cell activity.
Synonyms: G10D receptor
obsolete GPR37/endothelin B-like receptor activity (GO:0001606)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: GPR37/endothelin B-like receptor activity
Comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
G protein-coupled nucleotide receptor activity (GO:0001608)
Namespace: molecular_function
Definition: Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G protein coupled nucleotide receptor activity; G-protein coupled nucleotide receptor activity; nucleotide receptor activity, G protein coupled; nucleotide receptor activity, G-protein coupled
G protein-coupled adenosine receptor activity (GO:0001609)
Namespace: molecular_function
Definition: Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: A1 adenosine receptor activity, G protein coupled; A1 adenosine receptor activity, G-protein coupled; A2A adenosine receptor activity, G protein coupled; A2A adenosine receptor activity, G-protein coupled; A2B adenosine receptor activity, G protein coupled; A2B adenosine receptor activity, G-protein coupled; A3 adenosine receptor activity, G protein coupled; A3 adenosine receptor activity, G-protein coupled; adenosine nucleotide receptor; adenosine receptor activity, G protein coupled; adenosine receptor activity, G-protein coupled; G protein coupled A1 adenosine receptor activity; G protein coupled A2A adenosine receptor activity; G protein coupled A2B adenosine receptor activity; G protein coupled A3 adenosine receptor activity; G protein coupled adenosine receptor activity; G-protein coupled adenosine receptor activity; G-protein-coupled A1 adenosine receptor activity; G-protein-coupled A2A adenosine receptor activity; G-protein-coupled A2B adenosine receptor activity; G-protein-coupled A3 adenosine receptor activity; P1 receptor
growth hormone secretagogue receptor activity (GO:0001616)
Namespace: molecular_function
Definition: Combining with ghrelin to initiate a change in cell activity.
Synonyms: ghrelin receptor activity
obsolete growth hormone secretagogue-like receptor activity (GO:0001617)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: growth hormone secretagogue-like receptor activity
Comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
virus receptor activity (GO:0001618)
Namespace: molecular_function
Definition: Combining with a virus component and mediating entry of the virus into the cell.
Synonyms: viral receptor activity
obsolete lysosphingolipid and lysophosphatidic acid receptor activity (GO:0001619)
Namespace: molecular_function
Definition: OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity.
Synonyms: lysosphingolipid and lysophosphatidic acid receptor activity
G protein-coupled ADP receptor activity (GO:0001621)
Namespace: molecular_function
Definition: Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: ADP receptor activity; ADP-activated adenosine receptor activity; ADP-activated nucleotide receptor activity; K101 receptor; platelet ADP receptor activity
nociceptin receptor activity (GO:0001626)
Namespace: molecular_function
Definition: Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.
Synonyms: nociceptin/orphanin-FQ receptor activity; OFQ receptor activity; ORPH receptor; orphanin-FQ receptor activity; X-opioid receptor activity
obsolete leucine-rich G-protein receptor-like receptor activity (GO:0001627)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: leucine-rich G protein receptor-like receptor activity; leucine-rich G-protein receptor-like receptor activity; LGR-like receptor
Comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
obsolete gastropyloric receptor activity (GO:0001628)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: gastropyloric receptor activity; GPR receptor
Comment: This term was made obsolete because the gastropyloric receptor is a type of neuron.
obsolete G-protein receptor 45-like receptor activity (GO:0001629)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: G protein receptor 45-like receptor activity; G-protein receptor 45-like receptor activity; GPR45-like receptor
Comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
cysteinyl leukotriene receptor activity (GO:0001631)
Namespace: molecular_function
Definition: Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.
Synonyms: CysLT receptor
leukotriene B4 receptor activity (GO:0001632)
Namespace: molecular_function
Definition: Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.
Synonyms: BLT receptor
pituitary adenylate cyclase-activating polypeptide receptor activity (GO:0001634)
Namespace: molecular_function
Definition: A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide.
Synonyms: PACAP receptor; pituitary adenylate cyclase activating polypeptide receptor; pituitary adenylate cyclase activating protein receptor activity; pituitary adenylate cyclase-activating peptide receptor activity; pituitary adenylyl cyclase activating protein receptor activity
calcitonin gene-related peptide receptor activity (GO:0001635)
Namespace: molecular_function
Definition: Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.
Synonyms: calcitonin gene-related polypeptide receptor activity; CGRP receptor
obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity (GO:0001636)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
Comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
G protein-coupled chemoattractant receptor activity (GO:0001637)
Namespace: molecular_function
Definition: Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G protein chemoattractant receptor activity; G-protein chemoattractant receptor activity; G-protein coupled chemoattractant receptor activity
PLC activating G protein-coupled glutamate receptor activity (GO:0001639)
Namespace: molecular_function
Definition: A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.
Synonyms: Group I metabotropic glutamate receptor; group I metabotropic glutamate receptor activity; phospholipase C activating metabotropic glutamate receptor activity; PLC activating G-protein coupled glutamate receptor activity; PLC activating metabotropic glutamate receptor activity
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity (GO:0001640)
Namespace: molecular_function
Definition: Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
Synonyms: adenylate cyclase inhibiting metabotropic glutamate receptor activity; adenylyl cyclase inhibiting metabotropic glutamate receptor activity
group II metabotropic glutamate receptor activity (GO:0001641)
Namespace: molecular_function
Definition: A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.
group III metabotropic glutamate receptor activity (GO:0001642)
Namespace: molecular_function
Definition: A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.
cAMP receptor activity (GO:0001646)
Namespace: molecular_function
Definition: Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: 3',5' cAMP receptor activity; 3',5'-cAMP receptor activity; adenosine 3',5'-cyclophosphate receptor activity; class E G protein coupled receptor; class E G-protein coupled receptor; class E GPCR; cyclic AMP receptor activity
G protein-coupled cytokinin receptor activity (GO:0001647)
Namespace: molecular_function
Definition: Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: cytokinin receptor activity, G-protein coupled; G protein coupled cytokinin receptor activity; G-protein coupled cytokinin receptor activity
osteoblast differentiation (GO:0001649)
Namespace: biological_process
Definition: The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
Synonyms: osteoblast cell differentiation
fibrillar center (GO:0001650)
Namespace: cellular_component
Definition: A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
Synonyms: fibrillar centre
dense fibrillar component (GO:0001651)
Namespace: cellular_component
Definition: A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.
Synonyms: pars fibrosa
granular component (GO:0001652)
Namespace: cellular_component
Definition: A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.
Synonyms: pars granulosa
peptide receptor activity (GO:0001653)
Namespace: molecular_function
Definition: Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
Synonyms: endogenous peptide receptor activity; exogenous peptide receptor activity
eye development (GO:0001654)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
urogenital system development (GO:0001655)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
metanephros development (GO:0001656)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
ureteric bud development (GO:0001657)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
temperature homeostasis (GO:0001659)
Namespace: biological_process
Definition: A homeostatic process in which an organism modulates its internal body temperature.
Synonyms: thermoregulation
fever generation (GO:0001660)
Namespace: biological_process
Definition: The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
Synonyms: pyrexia
conditioned taste aversion (GO:0001661)
Namespace: biological_process
Definition: A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.
behavioral fear response (GO:0001662)
Namespace: biological_process
Definition: An acute behavioral change resulting from a perceived external threat.
Synonyms: behavioural fear response
G protein-coupled receptor binding (GO:0001664)
Namespace: molecular_function
Definition: Binding to a G protein-coupled receptor.
Synonyms: G protein coupled receptor binding; G protein coupled receptor ligand; G-protein coupled receptor binding; G-protein-coupled receptor ligand
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity (GO:0001665)
Namespace: molecular_function
Definition: Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.
Synonyms: GalNAc alpha-2,6-sialyltransferase I activity
response to hypoxia (GO:0001666)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Synonyms: response to hypoxic stress; response to intermittent hypoxia; response to lowered oxygen tension; response to sustained hypoxia
Comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
ameboidal-type cell migration (GO:0001667)
Namespace: biological_process
Definition: Cell migration that is accomplished by extension and retraction of a pseudopodium.
Synonyms: ameboid cell migration; amoeboid cell migration; amoeboidal cell migration
Comment: Note that this term refers to a mode of migration rather than to any particular cell type.
acrosomal vesicle (GO:0001669)
Namespace: cellular_component
Definition: A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
Synonyms: acrosomal granule; acrosome
ATPase activator activity (GO:0001671)
Namespace: molecular_function
Definition: Binds to and increases the activity of an ATP hydrolysis activity.
Synonyms: ATPase stimulator activity
male germ cell nucleus (GO:0001673)
Namespace: cellular_component
Definition: The nucleus of a male germ cell, a reproductive cell in males.
Synonyms: male germ-cell nucleus
female germ cell nucleus (GO:0001674)
Namespace: cellular_component
Definition: The nucleus of the female germ cell, a reproductive cell in females.
Synonyms: female germ-cell nucleus
acrosome assembly (GO:0001675)
Namespace: biological_process
Definition: The formation of the acrosome from the spermatid Golgi.
Synonyms: acrosome formation
long-chain fatty acid metabolic process (GO:0001676)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Synonyms: long-chain fatty acid metabolism
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
formation of translation initiation ternary complex (GO:0001677)
Namespace: biological_process
Definition: Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
Synonyms: translation initiation ternary complex assembly
intracellular glucose homeostasis (GO:0001678)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.
Synonyms: cell glucose homeostasis; cellular glucose homeostasis
tRNA 3'-terminal CCA addition (GO:0001680)
Namespace: biological_process
Definition: Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.
sialate O-acetylesterase activity (GO:0001681)
Namespace: molecular_function
Definition: Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.
Synonyms: N-acetylneuraminate acetyltransferase activity
tRNA 5'-leader removal (GO:0001682)
Namespace: biological_process
Definition: Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
Synonyms: tRNA 5' leader removal