LiteFold/GO huggingface dataset:
interleukin-9-mediated signaling pathway (GO:0038113)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-9 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-9-mediated signaling pathway; interleukin-9-mediated signalling pathway
interleukin-21-mediated signaling pathway (GO:0038114)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-21 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-21-mediated signaling pathway; interleukin-21-mediated signalling pathway
chemokine (C-C motif) ligand 19 signaling pathway (GO:0038115)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: C-C chemokine receptor type 7 signaling pathway; CCL19-mediated signaling pathway; chemokine (C-C motif) ligand 19 signalling pathway
Comment: The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'.
chemokine (C-C motif) ligand 21 signaling pathway (GO:0038116)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: C-C chemokine receptor type 7 signaling pathway; CCL21-mediated signaling pathway; chemokine (C-C motif) ligand 21 signalling pathway
Comment: The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
C-C motif chemokine 19 receptor activity (GO:0038117)
Namespace: molecular_function
Definition: Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: CCL19 receptor activity
C-C chemokine receptor CCR7 signaling pathway (GO:0038118)
Namespace: biological_process
Definition: The series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: C-C chemokine receptor CCR7 signalling pathway; CCR7 signaling pathway
Comment: This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
CCL19-activated CCR7 signaling pathway (GO:0038119)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CCL19-activated CCR7 signalling pathway
CCL21-activated CCR7 signaling pathway (GO:0038120)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CCL21-activated CCR7 signalling pathway
C-C motif chemokine 21 receptor activity (GO:0038121)
Namespace: molecular_function
Definition: Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: CCL21 receptor activity
C-C motif chemokine 5 receptor activity (GO:0038122)
Namespace: molecular_function
Definition: Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: CCL5 receptor activity; RANTES receptor activity; small inducible cytokine A5 receptor activity
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding of a heterodimeric TLR1:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: TLR2:TLR1 signaling pathway; toll-like receptor TLR1:TLR2 signalling pathway
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124)
Namespace: biological_process
Definition: The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: TLR2:TLR6 signaling pathway; toll-like receptor TLR6:TLR2 signalling pathway
ERBB signaling pathway (GO:0038127)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: EGF receptor family signaling pathway; EGFR family signaling pathway; ErbB signaling; ERBB signalling pathway
ERBB2 signaling pathway (GO:0038128)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
Synonyms: ERBB2 signalling pathway; HER2 signaling pathway; NEU signaling; receptor tyrosine-protein kinase erbB-2 signaling pathway
ERBB3 signaling pathway (GO:0038129)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission.
Synonyms: ERBB3 signalling pathway; HER3 signaling pathway; receptor tyrosine-protein kinase erbB-3 signaling pathway
neuregulin receptor activity (GO:0038131)
Namespace: molecular_function
Definition: Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: NRG receptor activity; NRG1 receptor activity; NRG2 receptor activity
Comment: Consider also annotating to 'ERBB3 signaling pathway ; GO:0038129' and/or 'ERBB4 signaling pathway ; GO:0038130'.
neuregulin binding (GO:0038132)
Namespace: molecular_function
Definition: Binding to a neuregulin, a member of the EGF family of growth factors.
ERBB2-ERBB3 signaling pathway (GO:0038133)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission.
Synonyms: ERBB2-ERBB3 signalling pathway; HER2-HER3 signaling pathway
ERBB2-EGFR signaling pathway (GO:0038134)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.
Synonyms: EGFR-HER2 signaling pathway; ERBB2-EGFR signalling pathway
ERBB2-ERBB4 signaling pathway (GO:0038135)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.
Synonyms: ERBB2-ERBB4 signalling pathway; HER2-HER4 signaling pathway
ERBB3-ERBB4 signaling pathway (GO:0038136)
Namespace: biological_process
Definition: The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms: ERBB3-ERBB4 signalling pathway; HER3-HER4 signaling pathway
ERBB4-EGFR signaling pathway (GO:0038137)
Namespace: biological_process
Definition: The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms: ERBB1-ERBB4 signaling pathway; ERBB4-EGFR signalling pathway; HER1-HER4 signaling pathway
ERBB4-ERBB4 signaling pathway (GO:0038138)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms: ERBB4 homodimeric signaling pathway; ERBB4-ERBB4 signalling pathway; HER4-HER4 signaling pathway
ERBB4-EGFR complex (GO:0038139)
Namespace: cellular_component
Definition: A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1).
Synonyms: EGFR-ERBB4 complex; ERBB4:EGFR heterodimer
ERBB4-ERBB3 complex (GO:0038140)
Namespace: cellular_component
Definition: A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission.
Synonyms: ERBB3-ERBB4 complex; ERBB4:ERBB3 heterodimer
ERBB4-ERBB4 complex (GO:0038141)
Namespace: cellular_component
Definition: A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4).
Synonyms: ERBB4 homodimer
EGFR:ERBB2 complex (GO:0038142)
Namespace: cellular_component
Definition: A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.
Synonyms: EGF:EGFR:ERBB2 complex; EGFR:ERBB2 heterodimer
ERBB3:ERBB2 complex (GO:0038143)
Namespace: cellular_component
Definition: A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3.
Synonyms: EGFR:ERBB2 heterodimer; NRG1/2:ERBB3:ERBB2
ERBB4:ERBB2 complex (GO:0038144)
Namespace: cellular_component
Definition: A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.
Synonyms: ERBB4:ERBB2 heterodimer; NRGs/EGFLs:ERBB4:ERBB2
macrophage colony-stimulating factor signaling pathway (GO:0038145)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: M-CSF signaling pathway; macrophage colony-stimulating factor signalling pathway
chemokine (C-X-C motif) ligand 12 signaling pathway (GO:0038146)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CXCL12 signaling pathway; CXCL12-activated CXCR7 signaling pathway; SDF1 signaling pathway; stromal cell-derived factor-1 signaling pathway
C-X-C motif chemokine 12 receptor activity (GO:0038147)
Namespace: molecular_function
Definition: Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: CXCL12 receptor activity; CXCR4; CXCR7; SDF-1 receptor activity; stromal cell-derived factor-1 receptor activity
chemokine (C-C motif) ligand 2 signaling pathway (GO:0038148)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CCL2 signaling pathway
C-C motif chemokine 2 receptor activity (GO:0038149)
Namespace: molecular_function
Definition: Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: CCL2 receptor activity
C-C chemokine receptor CCR2 signaling pathway (GO:0038150)
Namespace: biological_process
Definition: The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: C-C chemokine receptor type 2 signaling pathway
CCL2-activated CCR2 signaling pathway (GO:0038151)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CCL2/CCR2 signaling pathway
C-C chemokine receptor CCR4 signaling pathway (GO:0038152)
Namespace: biological_process
Definition: The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: C-C chemokine receptor type 4 signaling pathway; chemokine receptor CCR4 signaling pathway
CCL2-activated CCR4 signaling pathway (GO:0038153)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CCL2/CCR4 signaling pathway
interleukin-11-mediated signaling pathway (GO:0038154)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-11-mediated signaling pathway; interleukin-11-mediated signalling pathway
interleukin-23-mediated signaling pathway (GO:0038155)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-23 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-23-mediated signaling pathway; interleukin-23-mediated signalling pathway
interleukin-3-mediated signaling pathway (GO:0038156)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-3-mediated signaling pathway; interleukin-3-mediated signalling pathway
granulocyte-macrophage colony-stimulating factor signaling pathway (GO:0038157)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.
Synonyms: CSF2 signaling pathway; GM-CSF receptor signaling pathway; GM-CSF signaling pathway; granulocyte-macrophage colony-stimulating factor receptor signaling pathway; granulocyte-macrophage colony-stimulating factor signalling pathway
granulocyte colony-stimulating factor signaling pathway (GO:0038158)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R).
Synonyms: CSF3 signaling pathway; G-CSF receptor signaling pathway; G-CSF signaling pathway; granulocyte colony-stimulating factor receptor signaling pathway; granulocyte colony-stimulating factor signalling pathway
C-X-C chemokine receptor CXCR4 signaling pathway (GO:0038159)
Namespace: biological_process
Definition: The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CXCR4 signaling pathway
CXCL12-activated CXCR4 signaling pathway (GO:0038160)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: CXCL12-activated CXCR4 signalling pathway
thrombopoietin-mediated signaling pathway (GO:0038163)
Namespace: biological_process
Definition: The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: THPO signaling pathway; THPO/MPL signaling pathway; thrombopoietin receptor signaling pathway
thrombopoietin receptor activity (GO:0038164)
Namespace: molecular_function
Definition: Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
oncostatin-M-mediated signaling pathway (GO:0038165)
Namespace: biological_process
Definition: The series of molecular signals initiated by oncostatin-M (OSM) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways.
Synonyms: oncostatin-M signaling pathway; OSM signaling pathway
angiotensin-activated signaling pathway (GO:0038166)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: angiotensin II-mediated signaling pathway; angiotensin receptor signaling pathway; angiotensin-mediated signaling pathway
obsolete epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity (GO:0038167)
Namespace: biological_process
Definition: OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal transmitted via the activation of the transcription factor NF-kappaB.
Synonyms: EGFR signaling pathway via activation of NF-kappaB; epidermal growth factor receptor signalling pathway via positive regulation of NF-kappaB transcription factor activity
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade (GO:0038168)
Namespace: biological_process
Definition: OBSOLETE. An epidermal growth factor receptor signaling pathway in which the signal transmitted via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB.
Synonyms: EGFR signaling pathway via IKK-dependent activation of NF-kappaB; EGFR signaling pathway via IKK/NF-kappaB cascade
Comment: This term was obsoleted because it represents a GO-CAM model.
somatostatin receptor signaling pathway (GO:0038169)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms: SST receptor signaling pathway; SSTR signaling pathway
Comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'.
somatostatin signaling pathway (GO:0038170)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: somatostatin signalling pathway; somatostatin-activated somatostatin receptor signaling pathway; somatostatin-mediated signaling pathway; somatotrophin release inhibiting factor signaling pathway; SRIF signaling pathway; SST signaling pathway
cannabinoid signaling pathway (GO:0038171)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.
Synonyms: cannabinoid receptor signaling pathway; cannabinoid-activated signaling pathway; cannabinoid-mediated signaling pathway