LiteFold/GO huggingface dataset:
cleavage furrow (GO:0032154)
Namespace: cellular_component
Definition: The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
Comment: While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists.
germ tube septin cap (GO:0032171)
Namespace: cellular_component
Definition: A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.
obsolete ubiquinone biosynthetic process from tyrosine (GO:0032180)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate.
Comment: The reason for obsoletion is that it is more specific than the specificity of any known gene product.
SUMO polymer binding (GO:0032184)
Namespace: molecular_function
Definition: Binding to a polymer of the small ubiquitin-like protein SUMO.
Synonyms: Smt3 polymer binding
obsolete ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate (GO:0032194)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate.
Comment: The reason for obsoletion is that it is more specific than the specificity of any known gene product.
retrotransposition (GO:0032197)
Namespace: biological_process
Definition: A type of transposition in which a transposable element (transposon) copies and pastes itself into a different genomic location by transcription and convertsion of the transcribed RNA back into DNA through reverse transcription.
Synonyms: Class I transposition; retrotransposon transposition; RNA-mediated transposition; Tf transposition; transposition via RNA intermediate; transposition, RNA-mediated; Ty element transposition; Ty1 element transposition; Ty2 element transposition; Ty3 element transposition
negative regulation of telomere maintenance via recombination (GO:0032208)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.
Synonyms: down regulation of telomere maintenance via recombination; down-regulation of telomere maintenance via recombination; downregulation of telomere maintenance via recombination; inhibition of telomere maintenance via recombination
obsolete plasma membrane fusion involved in cytogamy (GO:0032220)
Namespace: biological_process
Definition: OBSOLETE. The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy.
Synonyms: plasma membrane fusion during cytogamy; plasma membrane organization involved in conjugation with cellular fusion
Comment: precomposed term, represents a GO-CAM model.
positive regulation of synaptic transmission, dopaminergic (GO:0032226)
Namespace: biological_process
Definition: Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.
Synonyms: activation of synaptic transmission, dopaminergic; stimulation of synaptic transmission, dopaminergic; up regulation of synaptic transmission, dopaminergic; up-regulation of synaptic transmission, dopaminergic; upregulation of synaptic transmission, dopaminergic
regulation of synaptic transmission, GABAergic (GO:0032228)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
negative regulation of nucleobase-containing compound transport (GO:0032240)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport; down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport; downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport; inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport; negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
regulation of nucleoside transport (GO:0032242)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of purine nucleoside transport (GO:0032245)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of purine nucleoside transport (GO:0032248)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: activation of purine nucleoside transport; stimulation of purine nucleoside transport; up regulation of purine nucleoside transport; up-regulation of purine nucleoside transport; upregulation of purine nucleoside transport
establishment of secretory granule localization (GO:0032254)
Namespace: biological_process
Definition: The directed movement of a secretory granule to a specific location.
Synonyms: establishment of secretory granule localisation
cytoplasm to vacuole targeting by the Cvt pathway (GO:0032258)
Namespace: biological_process
Definition: A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.
negative regulation of protein polymerization (GO:0032272)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.
Synonyms: down regulation of protein polymerization; down-regulation of protein polymerization; downregulation of protein polymerization; inhibition of protein polymerization
positive regulation of protein polymerization (GO:0032273)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
Synonyms: activation of protein polymerization; stimulation of protein polymerization; up regulation of protein polymerization; up-regulation of protein polymerization; upregulation of protein polymerization
peripheral nervous system axon ensheathment (GO:0032292)
Namespace: biological_process
Definition: The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.
Synonyms: ensheathment of axons in peripheral nervous system
double-stranded RNA-specific ribonuclease activity (GO:0032296)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules.
Synonyms: double-stranded RNA-specific RNase activity; dsRNA-specific ribonuclease activity; dsRNA-specific RNase activity
negative regulation of icosanoid secretion (GO:0032304)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.
Synonyms: down regulation of icosanoid secretion; down-regulation of icosanoid secretion; downregulation of icosanoid secretion; inhibition of icosanoid secretion; negative regulation of eicosanoid secretion
Mo-molybdopterin cofactor catabolic process (GO:0032326)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
Synonyms: Mo-molybdopterin cofactor breakdown; Mo-molybdopterin cofactor catabolism; Mo-molybdopterin cofactor degradation; Moco catabolic process; Moco catabolism
positive regulation of inhibin secretion (GO:0032340)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell.
Synonyms: activation of inhibin secretion; stimulation of inhibin secretion; up regulation of inhibin secretion; up-regulation of inhibin secretion; upregulation of inhibin secretion
aldosterone catabolic process (GO:0032343)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.
obsolete negative regulation of aldosterone metabolic process (GO:0032345)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.
Synonyms: down regulation of aldosterone metabolic process; down-regulation of aldosterone metabolic process; downregulation of aldosterone metabolic process; inhibition of aldosterone metabolic process; negative regulation of aldosterone metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
negative regulation of aldosterone biosynthetic process (GO:0032348)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.
Synonyms: down regulation of aldosterone biosynthetic process; down-regulation of aldosterone biosynthetic process; downregulation of aldosterone biosynthetic process; inhibition of aldosterone biosynthetic process
regulation of intracellular lipid transport (GO:0032377)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.
positive regulation of intracellular sterol transport (GO:0032382)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells.
Synonyms: activation of intracellular sterol transport; stimulation of intracellular sterol transport; up regulation of intracellular sterol transport; up-regulation of intracellular sterol transport; upregulation of intracellular sterol transport
negative regulation of intracellular cholesterol transport (GO:0032384)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells.
Synonyms: down regulation of intracellular cholesterol transport; down-regulation of intracellular cholesterol transport; downregulation of intracellular cholesterol transport; inhibition of intracellular cholesterol transport
photoreceptor connecting cilium (GO:0032391)
Namespace: cellular_component
Definition: The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.
Synonyms: photoreceptor cilium
MHC class Ib protein complex (GO:0032398)
Namespace: cellular_component
Definition: A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.
melanosome localization (GO:0032400)
Namespace: biological_process
Definition: Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.
Synonyms: melanosome localisation
establishment of melanosome localization (GO:0032401)
Namespace: biological_process
Definition: The directed movement of a melanosome to a specific location.
Synonyms: establishment of melanosome localisation
positive regulation of sodium:proton antiporter activity (GO:0032417)
Namespace: biological_process
Definition: Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Synonyms: activation of sodium:hydrogen antiporter activity; positive regulation of sodium:hydrogen antiporter activity; stimulation of sodium:hydrogen antiporter activity; up regulation of sodium:hydrogen antiporter activity; up-regulation of sodium:hydrogen antiporter activity; upregulation of sodium:hydrogen antiporter activity
negative regulation of mismatch repair (GO:0032424)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair.
Synonyms: down regulation of mismatch repair; down-regulation of mismatch repair; downregulation of mismatch repair; inhibition of mismatch repair
obsolete activation of phospholipase A2 activity (GO:0032431)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme phospholipase A2.
Synonyms: phospholipase A2 activation
Comment: This term was obsoleted because it represents a molecular function.
melanosome organization (GO:0032438)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
Synonyms: melanosome organisation; melanosome organization and biogenesis
protein urmylation (GO:0032447)
Namespace: biological_process
Definition: Covalent attachment of the ubiquitin-like protein URM1 to another protein.
DNA hairpin binding (GO:0032448)
Namespace: molecular_function
Definition: Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences.
nerve growth factor processing (GO:0032455)
Namespace: biological_process
Definition: The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor.
Synonyms: beta-nerve growth factor processing; NGF processing
regulation of protein homooligomerization (GO:0032462)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of protein homooligomerization.
cytoplasmic side of mitochondrial outer membrane (GO:0032473)
Namespace: cellular_component
Definition: The leaflet of the mitochondrial outer membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
Synonyms: cytosolic side of mitochondrial outer membrane; external leaflet of mitochondrial outer membrane; external side of mitochondrial envelope; external side of mitochondrial outer membrane
Comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane.
positive regulation of type I interferon production (GO:0032481)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms: activation of type I interferon production; positive regulation of type I IFN production; stimulation of type I interferon production; up regulation of type I interferon production; up-regulation of type I interferon production; upregulation of type I interferon production
Cdc42 protein signal transduction (GO:0032488)
Namespace: biological_process
Definition: An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal.
Synonyms: Cdc42 signaling; Cdc42 signaling pathway; cdc42 signalling pathway
detection of molecule of oomycetes origin (GO:0032492)
Namespace: biological_process
Definition: The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal.
Synonyms: detection of oomycetes associated molecule
detection of peptidoglycan (GO:0032499)
Namespace: biological_process
Definition: The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule.
multicellular organismal process (GO:0032501)
Namespace: biological_process
Definition: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
Synonyms: organismal physiological process; single-multicellular organism process
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
somite rostral/caudal axis specification (GO:0032525)
Namespace: biological_process
Definition: The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.
Synonyms: somite rostrocaudal axis specification; somite rostrocaudal polarity
response to retinoic acid (GO:0032526)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
Synonyms: response to vitamin A acid
regulation of host-seeking behavior (GO:0032538)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism.
Synonyms: regulation of host-seeking behaviour
plastid translation (GO:0032544)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
Synonyms: plastid protein anabolism; plastid protein biosynthesis; plastid protein formation; plastid protein synthesis; plastid protein translation
CURI complex (GO:0032545)
Namespace: cellular_component
Definition: A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.
guanyl deoxyribonucleotide binding (GO:0032560)
Namespace: molecular_function
Definition: Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.
dADP binding (GO:0032563)
Namespace: molecular_function
Definition: Binding to dADP, deoxyadenosine diphosphate.
Golgi cisterna membrane (GO:0032580)
Namespace: cellular_component
Definition: The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.
Synonyms: Golgi apparatus cisterna membrane; Golgi stack membrane
growth cone membrane (GO:0032584)
Namespace: cellular_component
Definition: The portion of the plasma membrane surrounding a growth cone.
type II interferon production (GO:0032609)
Namespace: biological_process
Definition: The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
Synonyms: IFNG production; interferon-gamma biosynthetic process; interferon-gamma production; interferon-gamma secretion; type II IFN production
interleukin-15 production (GO:0032618)
Namespace: biological_process
Definition: The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: IL-15 production; interleukin-15 biosynthetic process; interleukin-15 secretion
regulation of interleukin-19 production (GO:0032662)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of interleukin-19 production.
Synonyms: regulation of IL-19 production; regulation of interleukin-19 biosynthetic process
regulation of interleukin-2 production (GO:0032663)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of interleukin-2 production.
Synonyms: regulation of IL-2 production; regulation of interleukin-2 biosynthetic process; regulation of interleukin-2 secretion
regulation of interleukin-3 production (GO:0032672)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of interleukin-3 production.
Synonyms: regulation of IL-3 production; regulation of interleukin-3 biosynthetic process
regulation of interleukin-9 production (GO:0032678)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of interleukin-9 production.
Synonyms: regulation of IL-9 production; regulation of interleukin-9 biosynthetic process
regulation of TRAIL production (GO:0032679)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of TRAIL production.
Synonyms: regulation of TRAIL biosynthetic process
negative regulation of chemokine production (GO:0032682)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production.
Synonyms: down regulation of chemokine production; down-regulation of chemokine production; downregulation of chemokine production; inhibition of chemokine production; negative regulation of chemokine biosynthetic process; negative regulation of chemokine secretion
negative regulation of interferon-beta production (GO:0032688)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.
Synonyms: down regulation of interferon-beta production; down-regulation of interferon-beta production; downregulation of interferon-beta production; inhibition of interferon-beta production; negative regulation of IFN-beta production; negative regulation of interferon-beta biosynthetic process; negative regulation of interferon-beta secretion