LiteFold/GO huggingface dataset:
lamellocyte differentiation (GO:0035171)
Namespace: biological_process
Definition: The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.
Synonyms: lamellocyte cell differentiation
larval wandering behavior (GO:0035180)
Namespace: biological_process
Definition: The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction.
Synonyms: larval wandering behaviour
wing disc development (GO:0035220)
Namespace: biological_process
Definition: Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
obsolete negative regulation of glutamate-cysteine ligase activity (GO:0035228)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase.
Synonyms: down regulation of glutamate-cysteine ligase activity; down-regulation of glutamate-cysteine ligase activity; downregulation of glutamate-cysteine ligase activity; inhibition of glutamate-cysteine ligase activity
Comment: This term was obsoleted because it represents a molecular function.
synaptic transmission, glutamatergic (GO:0035249)
Namespace: biological_process
Definition: The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms: glutamatergic synaptic transmission
gonad morphogenesis (GO:0035262)
Namespace: biological_process
Definition: The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
pre-miRNA export from nucleus (GO:0035281)
Namespace: biological_process
Definition: Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product.
Synonyms: pre-microRNA export from cell nucleus; pre-microRNA export from nucleus; pre-microRNA export out of nucleus; pre-microRNA transport from nucleus to cytoplasm; pre-microRNA-nucleus export
head segmentation (GO:0035287)
Namespace: biological_process
Definition: Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial).
Comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children.
wing cell fate specification (GO:0035311)
Namespace: biological_process
Definition: The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment.
imaginal disc-derived wing hair outgrowth (GO:0035318)
Namespace: biological_process
Definition: Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair.
Synonyms: wing hair outgrowth; wing prehair outgrowth
long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Synonyms: long-chain fatty acyl CoA biosynthetic process; long-chain fatty-acyl-CoA anabolism; long-chain fatty-acyl-CoA biosynthesis; long-chain fatty-acyl-CoA formation; long-chain fatty-acyl-CoA synthesis
Comment: While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
negative regulation of inosine transport (GO:0035343)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: negative regulation of hypoxanthine riboside transport
peroxisome proliferator activated receptor signaling pathway (GO:0035357)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by a ligand binding to an intracellular peroxisome proliferator activated receptor (alpha, beta or gamma) of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: peroxisome proliferator activated receptor signalling pathway; peroxisome proliferator-activated receptor signaling pathway; PPAR signaling pathway
thymine transport (GO:0035364)
Namespace: biological_process
Definition: The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: 5-methyluracil transport; thymine transmembrane transport
selenocysteine insertion sequence binding (GO:0035368)
Namespace: molecular_function
Definition: Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.
Synonyms: SECIS binding
obsolete UBC13-UEV1A complex (GO:0035370)
Namespace: cellular_component
Definition: OBSOLETE. A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A).
Comment: This term was obsoleted because it represents the same concept as UBC13-MMS2 complex ; GO:0031372.
ATP-gated ion channel activity (GO:0035381)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.
positive regulation of Roundabout signaling pathway (GO:0035388)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway.
Synonyms: positive regulation of Roundabout signalling pathway
obsolete activation of MAPKK activity involved in innate immune response (GO:0035421)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.
regulation of gluconate transmembrane transport (GO:0035430)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore.
Synonyms: regulation of gluconate membrane transport; regulation of gluconate transport
nickel cation transmembrane transport (GO:0035444)
Namespace: biological_process
Definition: The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore.
Synonyms: nickel cation membrane transport
Comment: Note that this term is not intended for use in annotating lateral movement within membranes.
luteinizing hormone signaling pathway involved in ovarian follicle development (GO:0035471)
Namespace: biological_process
Definition: The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure.
Synonyms: luteinizing hormone signalling pathway involved in ovarian follicle development
DNA dealkylation (GO:0035510)
Namespace: biological_process
Definition: The removal of an alkyl group from one or more nucleotides within an DNA molecule.
obsolete monoubiquitinated histone deubiquitination (GO:0035521)
Namespace: biological_process
Definition: OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone protein.
Synonyms: monoubiquitinated histone deubiquitinylation; monoubiquitinated histone deubiquitylation
Comment: This term was obsoleted because it represents a molecular function.
protein K29-linked deubiquitination (GO:0035523)
Namespace: biological_process
Definition: A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein.
Synonyms: protein K29-linked deubiquitinylation; protein K29-linked deubiquitylation
regulation of chemokine (C-C motif) ligand 6 production (GO:0035531)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).
Synonyms: chemokine (C-C motif) ligand 6 secretion; regulation of CCL6 production; regulation of chemokine (C-C motif) ligand 6 secretion
positive regulation of SNARE complex disassembly (GO:0035540)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
negative regulation of SNARE complex disassembly (GO:0035541)
Namespace: biological_process
Definition: Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
obsolete oxidative single-stranded RNA demethylation (GO:0035553)
Namespace: biological_process
Definition: OBSOLETE. Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
Synonyms: oxidative ssRNA demethylation
Comment: This term was obsoleted because it represents a molecular function.
obsolete intracellular signal transduction involved in cell surface receptor linked signaling (GO:0035557)
Namespace: biological_process
Definition: OBSOLETE. The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms: intracellular signal transduction involved in cell surface receptor linked signaling; intracellular signal transduction involved in cell surface receptor linked signalling; intracellular signaling cascade involved in cell surface receptor linked signaling; intracellular signaling chain involved in cell surface receptor signaling
Comment: This term was made obsolete because the syntax of the term is incorrect.
histone H4K20 demethylase activity (GO:0035575)
Namespace: molecular_function
Definition: Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
Synonyms: histone demethylase activity (H4-K20 specific); histone demethylase activity (H4K20-specific); histone H4-K20 demethylase activity; histone H4-methyl-lysine-20 demethylase activity; histone H4K20me demethylase activity
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
obsolete sequestering of BMP in extracellular matrix (GO:0035582)
Namespace: biological_process
Definition: OBSOLETE. Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
Synonyms: BMP sequestration in the ECM; negative regulation of BMP signaling pathway by extracellular sequestering of BMP; negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP; negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein
Comment: The reason for obsoletion is that this term represents a molecular function and not a real GO process.
G protein-coupled purinergic nucleotide receptor signaling pathway (GO:0035589)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process.
Synonyms: G-protein coupled purinergic nucleotide receptor signaling pathway; G-protein coupled purinergic nucleotide receptor signalling pathway; P2Y receptor signaling pathway
methylthiotransferase activity (GO:0035596)
Namespace: molecular_function
Definition: Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor.
Synonyms: MTTase
aspartic acid methylthiotransferase activity (GO:0035599)
Namespace: molecular_function
Definition: Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid.
Comment: Note that peptidyl-L-beta-methylthioaspartic acid is typical of bacterial ribosomal protein S12.
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development (GO:0035607)
Namespace: biological_process
Definition: The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state.
Synonyms: FGF receptor signaling pathway involved in orbitofrontal cortex development; FGFR signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development
C-terminal protein deglutamylation (GO:0035609)
Namespace: biological_process
Definition: The removal of a C-terminal, gene-encoded glutamate residue from a protein.
Synonyms: protein primary sequence deglutamylation
clathrin-cargo adaptor activity (GO:0035615)
Namespace: molecular_function
Definition: Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.
Synonyms: clathrin adaptor activity; clathrin-associated adaptor activity
intrahepatic bile duct development (GO:0035622)
Namespace: biological_process
Definition: The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).
Synonyms: IHBD development; intrahepatic biliary duct development
mitochondrial prohibitin complex (GO:0035632)
Namespace: cellular_component
Definition: A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death.
Synonyms: mitochondrial inner membrane prohibitin complex
Mon1-Ccz1 complex (GO:0035658)
Namespace: cellular_component
Definition: A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.
Toll-like receptor 2 binding (GO:0035663)
Namespace: molecular_function
Definition: Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.
Synonyms: TLR2 binding
T-helper 1 cell extravasation (GO:0035687)
Namespace: biological_process
Definition: The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.
Synonyms: Th1 cell extravasation
CD8-positive, alpha-beta T cell extravasation (GO:0035697)
Namespace: biological_process
Definition: The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue.
hematopoietic stem cell migration (GO:0035701)
Namespace: biological_process
Definition: The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
Synonyms: hemopoietic stem cell migration
chemokine (C-C motif) ligand 2 binding (GO:0035715)
Namespace: molecular_function
Definition: Binding to chemokine (C-C motif) ligand 2.
Synonyms: CCL2 binding
S-nitrosoglutathione binding (GO:0035730)
Namespace: molecular_function
Definition: Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.
Synonyms: GSNO binding
granzyme A production (GO:0035746)
Namespace: biological_process
Definition: The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
platelet-derived growth factor receptor-beta signaling pathway (GO:0035791)
Namespace: biological_process
Definition: The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: betaPDGF receptor signaling pathway; PDGF receptor-beta signaling pathway; PDGFR-beta signaling pathway; platelet-derived growth factor receptor-beta signalling pathway
adrenal cortex formation (GO:0035802)
Namespace: biological_process
Definition: The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).
Synonyms: adrenal gland cortex formation
positive regulation of urine volume (GO:0035810)
Namespace: biological_process
Definition: Any process that increases the amount of urine excreted from the body over a unit of time.
Synonyms: diuresis; elevation of urinary volume; increase in urine flow
negative regulation of renal sodium excretion (GO:0035814)
Namespace: biological_process
Definition: Any process that decreases the amount of sodium excreted in urine over a unit of time.
Comment: The amount of sodium excreted in urine over a unit of time can be decreased by decreasing the volume of urine produced (antidiuresis) and/or by decreasing the concentration of sodium in the urine.
positive regulation of urine volume by pressure natriuresis (GO:0035818)
Namespace: biological_process
Definition: An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis.
Synonyms: diuresis resulting from pressure natriuresis
short tract gene conversion (GO:0035823)
Namespace: biological_process
Definition: A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor.
cloaca development (GO:0035844)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.
Synonyms: cloacal development
eosinophil fate commitment (GO:0035854)
Namespace: biological_process
Definition: The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin.
Synonyms: eosinophil cell fate commitment
Seh1-associated complex (GO:0035859)
Namespace: cellular_component
Definition: A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.
Synonyms: GATOR complex; SEA complex
Comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
obsolete dITP metabolic process (GO:0035862)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.
Synonyms: 2'-Deoxyinosine 5'-triphosphate metabolic process; 2'-Deoxyinosine-5'-triphosphate metabolic process; deoxyinosine 5'-triphosphate metabolic process; deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process; dITP metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.