LiteFold/GO huggingface dataset:
upstream stimulatory factor complex (GO:1990378)
Namespace: cellular_component
Definition: A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters.
Synonyms: USF complex; USF1 homodimer; USF1-USF2 heterodimer; USF2 homodimer
Comment: An example of this is USF1 in human (UniProt symbol P22415) in PMID:8576131 (inferred from direct assay).
meiotic spindle midzone (GO:1990385)
Namespace: cellular_component
Definition: The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap.
xylem-to-phloem iron transport (GO:1990388)
Namespace: biological_process
Definition: The directed movement of iron ions into the phloem from the xylem.
embryonic lung development (GO:1990401)
Namespace: biological_process
Definition: The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure.
protein antigen binding (GO:1990405)
Namespace: molecular_function
Definition: Binding to a protein antigen.
cellular response to brain-derived neurotrophic factor stimulus (GO:1990416)
Namespace: biological_process
Definition: A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
Synonyms: cellular response to BDNF stimulus
glyoxalase (glycolic acid-forming) activity (GO:1990422)
Namespace: molecular_function
Definition: Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor.
CSL-Notch-Mastermind transcription factor complex (GO:1990433)
Namespace: cellular_component
Definition: A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes.
Synonyms: CSL-NotchIC-MASTERMIND complex
U2 snRNP binding (GO:1990447)
Namespace: molecular_function
Definition: Binding to a U2 small nuclear ribonucleoprotein particle.
mitochondrion-endoplasmic reticulum membrane tethering (GO:1990456)
Namespace: biological_process
Definition: The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
Synonyms: mitochondrion-endoplasmic reticulum attachment; mitochondrion-endoplasmic reticulum tethering; mitochondrion-ER attachment; mitochondrion-ER membrane tethering; mitochondrion-ER tethering
pexophagosome (GO:1990457)
Namespace: cellular_component
Definition: A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy.
piRNA uni-strand cluster binding (GO:1990471)
Namespace: molecular_function
Definition: Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa.
synaptic vesicle, recycling pool (GO:1990475)
Namespace: cellular_component
Definition: A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state.
Synonyms: recycling pool of synaptic vesicles
obsolete response to lipoic acid (GO:1990479)
Namespace: biological_process
Definition: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus.
Synonyms: response to 5-(1,2-dithiolan-3-yl)pentanoic acid
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete cyclin H-CDK7 complex (GO:1990493)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
Synonyms: cyclin H-CDK7 complex
Comment: This term was made obsolete because it was added in error.
obsolete actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly (GO:1990495)
Namespace: biological_process
Definition: OBSOLETE. An actin filament organization process that contributes to actomyosin contractile ring assembly during mitotic cytokinesis.
Synonyms: actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
3' transitive RNA interference (GO:1990515)
Namespace: biological_process
Definition: An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA.
Rvs161p-Rvs167p complex (GO:1990528)
Namespace: cellular_component
Definition: A protein complex that is involved in endocytosis in the yeast S. cerevisiae.
Cdc50p-Drs2p complex (GO:1990530)
Namespace: cellular_component
Definition: A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome.
mitotic spindle polar microtubule (GO:1990537)
Namespace: cellular_component
Definition: Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone.
mitochondrial coenzyme A transmembrane transport (GO:1990559)
Namespace: biological_process
Definition: The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion.
I(KACh) inward rectifier potassium channel complex (GO:1990566)
Namespace: cellular_component
Definition: An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signaling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits.
Synonyms: GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex; Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex; muscarinic potassium channel complex
Comment: Examples of this are KCNJ3 and KCNJ5 in human (Uniprot symbols P48549 and P48544) in PMID:9765280 inferred from orthology sequence evidence.
G protein-coupled glucose receptor activity (GO:1990576)
Namespace: molecular_function
Definition: Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms: G-protein coupled glucose receptor activity
obsolete lysosome lysis (GO:1990581)
Namespace: biological_process
Definition: OBSOLETE. The rupture of the lysosomal membrane and loss of contents as a result of osmotic change, G-protein-driven disintegration, or unspecified cause.
Synonyms: lysosomal lysis; lysosome lysis
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
divisome complex (GO:1990586)
Namespace: cellular_component
Definition: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells.
mast cell secretagogue receptor activity (GO:1990595)
Namespace: molecular_function
Definition: Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells.
obsolete importin alpha-subunit nuclear import complex (GO:1990602)
Namespace: cellular_component
Definition: OBSOLETE. A trimeric protein complex which functions to transport the importin alpha-subunit into the nucleus through the nuclear pore to facilitate another round of mRNP incorporation and regulation. In Drosophila it consists of Cdm (Imp13), Mago and Tsu (Y14).
Synonyms: Cdm-Mago-Tsu complex; Importin13-Mago-Tsu complex
Comment: The reason for obsoletion is that these terms include the substrate of the reaction.
obsolete Sigma-E factor negative regulation complex (GO:1990628)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex consisting of RseA, RseB and RpoE. It form the inactive form of the sigma-E transcription factor. In response to stress, outer membrane proteins accumulate in the periplasm and activate cleavage of RseA periplasmic domain by DegS, triggering a proteolytic cascade that frees sigma-E to activate gene expression. RseB binding to RseA prevents activated DegS from cleaving RseA. Sigma-E-mediated envelope stress response is the major pathway to ensure homeostasis in the envelope compartment of the cell.
Synonyms: RseA-RseB-RpoE complex; Sigma-E factor negative regulation complex
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
IRE1-RACK1-PP2A complex (GO:1990630)
Namespace: cellular_component
Definition: A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A.
Synonyms: ERN1-RACK1-PP2A complex; IRE1alpha-RACK1-PP2A complex
obsolete branching involved in submandibular gland morphogenesis (GO:1990632)
Namespace: biological_process
Definition: OBSOLETE. The process in which the branching structure of the submandibular gland is generated and organized.
Synonyms: submandibular gland branching morphogenesis; submandibular gland ductal branching
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
proximal dendrite (GO:1990635)
Namespace: cellular_component
Definition: The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma).
reproductive senescence (GO:1990636)
Namespace: biological_process
Definition: A life cycle stage during which the reproductive capacity and fitness of an organism declines.
Synonyms: ovarian senescence
Comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
PCSK9-LDLR complex (GO:1990666)
Namespace: cellular_component
Definition: A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.
Synonyms: PCSK9.LDLR complex; PCSK9/LDL-R complex; PCSK9:EGF-A complex; PCSK9:low-density lipoprotein receptor complex
PCSK9-AnxA2 complex (GO:1990667)
Namespace: cellular_component
Definition: A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2).
Synonyms: PCSK9-Annexin A2 complex; PCSK9.AnxA2 complex; PCSK9:ANXA2 complex
vesicle fusion with Golgi medial cisterna membrane (GO:1990671)
Namespace: biological_process
Definition: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles.
protein depalmitoleylation (GO:1990697)
Namespace: biological_process
Definition: The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein.
obsolete integral component of Golgi medial cisterna membrane (GO:1990703)
Namespace: cellular_component
Definition: OBSOLETE. The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Synonyms: integral component of medial-Golgi cisterna membrane
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
MAD1 complex (GO:1990706)
Namespace: cellular_component
Definition: A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C).
Synonyms: MAD1 homodimer
obsolete prostatic acid phosphatase complex (GO:1990721)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP.
Synonyms: ACPP homodimer complex; PAP complex; prostatic acid phosphatase complex
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
regulation of vascular associated smooth muscle cell membrane depolarization (GO:1990736)
Namespace: biological_process
Definition: Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell.
Synonyms: regulation of vascular smooth muscle cell membrane depolarization
granulosa cell proliferation (GO:1990739)
Namespace: biological_process
Definition: The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge.
obsolete GABAergic neuronal action potential (GO:1990754)
Namespace: biological_process
Definition: OBSOLETE. An action potential that occurs in a GABAergic neuron.
Synonyms: GABAergic neuronal action potential
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
cytoplasmic alanyl-tRNA aminoacylation (GO:1990762)
Namespace: biological_process
Definition: The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation.
proximal neuron projection (GO:1990769)
Namespace: cellular_component
Definition: The portion of an axon or dendrite that is close to the neuronal cell body.
response to angiotensin (GO:1990776)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
protein localization to cell periphery (GO:1990778)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, the cell periphery.
periphagosomal region of cytoplasm (GO:1990783)
Namespace: cellular_component
Definition: Cytoplasm situated near, or occurring around, a phagosome.
thyroid gland epithelial cell proliferation (GO:1990789)
Namespace: biological_process
Definition: The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population.
Synonyms: Hurthle cell proliferation; thyroid follicular cell proliferation
obsolete meiotic APC-fizzy-related complex (GO:1990800)
Namespace: cellular_component
Definition: OBSOLETE. An anaphase promoting complex bound to a fizzy-related family APC activator that regulates meiotic exit by activating the APC/C to target meiotic cyclins for destruction during meiosis.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
obsolete protein phosphorylation involved in double-strand break repair via nonhomologous end joining (GO:1990804)
Namespace: biological_process
Definition: OBSOLETE. Any protein phosphorylation process that is required for double-strand break repair via nonhomologous end joining.
Synonyms: protein amino acid phosphorylation involved in double-strand break repair via nonhomologous end joining; protein amino acid phosphorylation involved in NHEJ; protein phosphorylation involved in NHEJ
Comment: This term has been obsoleted because it represents a GO-CAM model.
F-bar domain binding (GO:1990808)
Namespace: molecular_function
Definition: Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins.
endoplasmic reticulum tubular network membrane organization (GO:1990809)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane.
DNA/DNA annealing activity (GO:1990814)
Namespace: molecular_function
Definition: An activity that facilitates the formation of a complementary double-stranded DNA molecule.
Synonyms: DNA reannealing activity
obsolete regulation of protein localization to cell division site after cytokinesis (GO:1990815)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in cell separation after cytokinesis.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
clathrin-uncoating ATPase activity (GO:1990833)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP.
Wnt-Frizzled-LRP5/6 complex (GO:1990851)
Namespace: cellular_component
Definition: A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6.
Synonyms: Frizzled-LRP5/6 complex; Fz/Wnt/LRP6 complex; Wnt receptor complex; WNT-FZD-LRP5 complex; Wnt-FZD-LRP5/6 trimeric complex; WNT-FZD-LRP6 complex; Wnt-induced Frizzled-LRP5/6 complex; Wnt.Fz.LRP ternary complex
Comment: Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form.
obsolete histone H2A SQE motif phosphorylation (GO:1990853)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone.
Comment: This term was obsoleted because it represents a molecular function.
obsolete response to intermittent hypoxia (GO:1990865)
Namespace: biological_process
Definition: OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
response to chemokine (GO:1990868)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
obsolete protein serine/threonine kinase binding (GO:1990885)
Namespace: molecular_function
Definition: OBSOLETE. Binding to a protein serine/threonine kinase.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
dinoflagellate peduncle (GO:1990905)
Namespace: cellular_component
Definition: A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy).
Comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures.
response to psychosocial stress (GO:1990911)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.
ooplasm (GO:1990917)
Namespace: cellular_component
Definition: The cytoplasm of an ovum.
obsolete proteasome localization to nuclear periphery (GO:1990920)
Namespace: biological_process
Definition: OBSOLETE. Any process in which the proteasome is transported to, or maintained at the nuclear periphery.
Comment: This term was obsoleted because it represents a molecular function.
mitotic metaphase chromosome recapture (GO:1990942)
Namespace: biological_process
Definition: A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate.
Synonyms: kinetochore retrieval; metaphase chromosome retrieval to the spindle pole body; microtubule sliding involved in kinetochore retrieval; microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body; microtubule sliding involved in mitotic metaphase chromosome recapture; microtubule sliding involved in sister kinetochore recapture; sister kinetochore recapture
meiosis I/meiosis II transition (GO:1990946)
Namespace: biological_process
Definition: The cell cycle process in which a cell progresses from meiosis I to meiosis II.
ubiquitin ligase inhibitor activity (GO:1990948)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.
Synonyms: APC-Cdc20 complex inhibitor activity; mitotic anaphase-promoting complex inhibitor activity
obsolete regulation of protein localization to cell division site involved in cell separation after cytokinesis (GO:1990981)
Namespace: biological_process
Definition: OBSOLETE. A regulation of protein localization to cell division site involved in cell separation after cytokinesis.
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
positive regulation of protein localization to cell surface (GO:2000010)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
Synonyms: positive regulation of protein localisation at cell surface; positive regulation of protein localization at cell surface
regulation of adaxial/abaxial pattern formation (GO:2000011)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation.
Synonyms: regulation of adaxial/abaxial pattern specification
regulation of photoperiodism, flowering (GO:2000028)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of photoperiodism, flowering.
Synonyms: regulation of photoperiodic control of flowering time; regulation of photoperiodic control of inflorescence development; regulation of response to day length, flowering; regulation of response to night length, flowering; regulation of response to photoperiod, flowering