LiteFold/GO huggingface dataset:
rixosome complex (GO:0120330)
Namespace: cellular_component
Definition: A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans.
Synonyms: rix1 complex
endothelial tube formation (GO:0120331)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of an endothelial tube.
histone H3K79 dimethyltransferase activity (GO:0120506)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl79-[histone H3] + 2 S-adenosyl-L-methionine = 2H+ + N6,N6-methyl-L-lysyl79-[histone H3] + 2 S-adenosyl-L-homocysteine.
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
hydroxypyruvate reductase (NADPH) activity (GO:0120509)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-glycerate + NADP+ = 3-hydroxypyruvate + NADPH + H+.
mitochondrial [4Fe-4S] assembly complex (GO:0120510)
Namespace: cellular_component
Definition: A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in mitochondria. In S. cerevisiae, it consists of Isa1 and Isa2. In humans it consists of ISCA1 and ISCA2. Additional proteins may be present.
Synonyms: iron-sulfur assembly complex; ISA complex
inositol pentakisphosphate kinase activity (GO:0120517)
Namespace: molecular_function
Definition: Catalysis of the reaction: inositol pentakisphosphate + ATP = inositol hexakisphosphate + ADP + H+.
tubulin N-terminal-methionine acetyltransferase activity (GO:0120519)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H+ + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]. The N-terminus of both alpha- and beta-tubulin are acetylated.
Synonyms: tubulin N-terminal N-acetyltransferase activity
aliphatic desulfoglucosinolate sulfotransferase activity (GO:0120527)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H+.
glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (non-phosphorylating) activity (GO:0120533)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O = (2R)-3-phosphoglycerate + NAD(P)H + 2 H+.
Synonyms: GAPN activity; non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase activity
nucleic acid conformation isomerase activity (GO:0120545)
Namespace: molecular_function
Definition: Catalysis of a reaction that alters the conformation of a nucleic acid.
phosphatidylinositol phospholipase C activity (GO:0120548)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+.
Synonyms: phosphatidylinositol phospholipase C-type activity
NADH dehydrogenase (ubiquinone) (non-electrogenic) activity (GO:0120555)
Namespace: molecular_function
Definition: Catalysis of the reaction: a ubiquinone + NADH + H+ = a ubiquinol + NAD+.
dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity (GO:0120563)
Namespace: molecular_function
Definition: Catalysis of the transfer of an alpha-D-mannosyl residue from dolichol-P-mannose to Man(1)-GlcN-acyl-PI, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage. This transfers the second mannose to the GPI precursor.
Synonyms: glycosylphosphatidylinositol-mannosyltransferase II activity; GPI-MT-II activity
GPI anchor remodelling (GO:0120574)
Namespace: biological_process
Definition: Any process leading to the modification of the GPI-anchor after its transfer and attachment to a protein.
histone H3Q5ser reader activity (GO:0140004)
Namespace: molecular_function
Definition: A histone reader that recognizes a histone H3 serotonylated at glutamine 5.
Synonyms: H3Q5-serotonin histone reader activity; H3Q5-serotonin modified histone binding
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
mitotic nuclear division (GO:0140014)
Namespace: biological_process
Definition: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
Synonyms: mitosis
mitochondrial ADP transmembrane transport (GO:0140021)
Namespace: biological_process
Definition: The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion.
contractile vacuole tethering involved in discharge (GO:0140025)
Namespace: biological_process
Definition: The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.
Synonyms: contractile vacuole tethering to plasma membrane
cellular detoxification of methylglyoxal (GO:0140041)
Namespace: biological_process
Definition: Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal. These may include chemical modification or transport of methylglyoxal away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
lipid droplet formation (GO:0140042)
Namespace: biological_process
Definition: A process that results in the assembly, arrangement of constituent parts of a lipid droplet.
Synonyms: adiposome formation; lipid body formation; lipid particle formation
positive regulation of endocardial cushion to mesenchymal transition (GO:0140051)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition.
peptidyl-lysine crotonylation (GO:0140066)
Namespace: biological_process
Definition: The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid.
basement membrane/interstitial matrix interface (GO:0140086)
Namespace: cellular_component
Definition: The structure located at the interface of the basement membrane and interstitial extracellular matrix and anchoring the two types of ECM to one another.
protein storage (GO:0140089)
Namespace: biological_process
Definition: The accumulation and maintenance in cells of proteins. Protein reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
structural constituent of cytoplasmic lattice (GO:0140094)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of cytoplasmic lattice of the the mammalian ooplasm.
catalytic activity, acting on DNA (GO:0140097)
Namespace: molecular_function
Definition: Catalytic activity that acts to modify DNA.
lytic exotransglycosylase activity (GO:0140100)
Namespace: molecular_function
Definition: Catalysis of the exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
Synonyms: murein lytic endotransglycosylase E activity
iron-sulfur cluster chaperone activity (GO:0140132)
Namespace: molecular_function
Definition: Binding to an iron-sulfur cluster and delivering it to an acceptor molecule.
Synonyms: iron-sulfur cluster carrier activity
venom-mediated perturbation of nervous system process (GO:0140136)
Namespace: biological_process
Definition: A process in which an organism alters or subverts a nervous system process in another organism via the action of a venom.
gel phase of basement membrane (GO:0140148)
Namespace: cellular_component
Definition: Gel formed of proteglycans filling the basement membrane ECM space.
(2R)-2-hydroxycarboxylate dehydrogenase activity (GO:0140174)
Namespace: molecular_function
Definition: Catalysis of the activity: a (2R)-2-hydroxycarboxylate + FAD + H+ = a 2-oxocarboxylate + FADH2.
venom-mediated suppression of blood coagulation, intrinsic pathway (GO:0140184)
Namespace: biological_process
Definition: A process in which an organism inhibits or disrupts blood coagulation in another organism by suppression of the intrinsic pathway via the action of a venom. A common mechanism is the blocking the activity of host coagulation Factor XIIa (F12).
Synonyms: venom-mediated suppression of blood coagulation cascade, contact activation system
regulation of translation at postsynapse (GO:0140245)
Namespace: biological_process
Definition: Any process that regulates translation occurring at the postsynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
protein catabolic process at postsynapse (GO:0140249)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation protein catabolic process at synapse (GO:0140250)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.
Comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
cell-cell fusion (GO:0140253)
Namespace: biological_process
Definition: A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.
Synonyms: cell cell fusion; cell fusion; plasma membrane fusion
symbiont entry into host cell via permeabilization of host membrane (GO:0140267)
Namespace: biological_process
Definition: The entry of a symbiont into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration symbiont protein. This process mediates the entry of some non-enveloped virus into host cells, and results in the release of the virus contents into the host cell cytoplasm.
Synonyms: viral entry via permeabilization of host membrane
hexose import across plasma membrane (GO:0140271)
Namespace: biological_process
Definition: The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol.
obsolete pericentric heterochromatin maintenance (GO:0140276)
Namespace: biological_process
Definition: OBSOLETE. Any heterochromatin maintenance that is involved in chromatin silencing at or near a centromere.
Synonyms: heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region; heterochromatin maintenance involved in chromatin silencing at centromeric outer repeats; heterochromatin maintenance involved in chromatin silencing at pericentric region
Comment: This term was obsoleted because it represents a phenotype.
mitotic division septum assembly (GO:0140278)
Namespace: biological_process
Definition: The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
regulation of mitotic division septum assembly (GO:0140279)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
Synonyms: regulation of division septum formation involved in mitotic cell cycle; regulation of formation of division septum involved in mitotic cell cycle; regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle; regulation of septin assembly and septum formation involved in mitotic cell cycle
ADP-ribosylglutamate hydrolase activity (GO:0140293)
Namespace: molecular_function
Definition: Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose.
lysophospholipid translocation (GO:0140329)
Namespace: biological_process
Definition: The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
lipopolysaccharide localization to cell outer membrane (GO:0140334)
Namespace: biological_process
Definition: A process in which a lipopolysaccharide is transported to the cell outer membrane.
Synonyms: LPS localization to cell outer membrane
diacylglyceride transfer activity (GO:0140337)
Namespace: molecular_function
Definition: Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location.
Synonyms: diacylglyceride carrier activity
phosphatidylcholine flippase activity (GO:0140345)
Namespace: molecular_function
Definition: Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: phosphatidylcholine flippase activity (exoplasmic to cytosolic leaflet)
RNP body (GO:0140365)
Namespace: cellular_component
Definition: A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules.
Synonyms: BR-body
obsolete histone H3 ubiquitination (GO:0140372)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the addition of one or more ubiquitin groups.
Synonyms: histone H3 ubiquitylation
Comment: This term was obsoleted because it represents a molecular function.
amino acid acyltransferase activity (GO:0140379)
Namespace: molecular_function
Definition: Catalysis of the transfer of an acyl group to an acceptor group on a free amino acid, usually using acetyl-CoA as donor.
Synonyms: amino acid N-acetyltransferase activity
positive regulation of mRNA alternative polyadenylation (GO:0140409)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation.
heme import into cell (GO:0140420)
Namespace: biological_process
Definition: The directed movement of a heme from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
Synonyms: heme assimilation
5'-hydroxyl dinucleotide hydrolase activity (GO:0140432)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-NpN-RNA + H20 = 5'OH-NpN + 5'P-RNA, where NpN represents a dinucleotide.
negative regulation of protein localization to meiotic spindle pole body (GO:0140435)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a meiotic spindle pole body.
protein-cysteine S-arachidonoyltransferase activity (GO:0140441)
Namespace: molecular_function
Definition: Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein].
peroxide sensor activity (GO:0140442)
Namespace: molecular_function
Definition: Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.
counting factor complex (GO:0140451)
Namespace: cellular_component
Definition: A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum.
obsolete subtelomeric heterochromatin organization (GO:0140461)
Namespace: biological_process
Definition: OBSOLETE. The organization of chromatin into heterochromatin at the subtelomeric region of a chromosome.
Comment: This term has been obsoleted because it represents a different process, GO:0097240 attachment of telomeric heterochromatin to nuclear envelope.
telomere-nuclear envelope anchor activity (GO:0140473)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location.
Synonyms: nuclear envelope-telomere anchor activity; telomere-nuclear envelope anchoring activity
mannan polymerase I complex (GO:0140498)
Namespace: cellular_component
Definition: A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p.
mitotic nuclear bridge midzone (GO:0140512)
Namespace: cellular_component
Definition: The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei.
nuclear protein-containing complex (GO:0140513)
Namespace: cellular_component
Definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
Synonyms: nuclear complex
protein-RNA adaptor activity (GO:0140517)
Namespace: molecular_function
Definition: The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way.
antipodal site (GO:0140525)
Namespace: cellular_component
Definition: The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication.
Synonyms: antipodal zone
CMG complex assembly (GO:0140529)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes.
intracellular protein-containing complex (GO:0140535)
Namespace: cellular_component
Definition: A protein-containing complex located intracellularly.
extraction of mislocalized protein from mitochondrial outer membrane (GO:0140570)
Namespace: biological_process
Definition: The removal of a mislocalized protein from the mitochondrial outer membrane.
Synonyms: extraction of mislocalized protein from outer mitochondrion membrane
mitochondrion autophagosome adaptor activity (GO:0140580)
Namespace: molecular_function
Definition: The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy.
Synonyms: mitophagy receptor
P-type monovalent copper transporter activity (GO:0140581)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out).
Comment: Note that this enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC:7.2.2.9, which mainly transports the divalent copper ion (source: EC:7.2.2.8).
obsolete ATP hydrolysis activity (GO:0140603)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
Comment: This term was deprecated because it was created in the wrong branch on the ontology.
EGAD pathway (GO:0140624)
Namespace: biological_process
Definition: The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation.
opioid growth factor receptor activity (GO:0140625)
Namespace: molecular_function
Definition: Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes.
Synonyms: met-enkephalin receptor activity; metenkefalin receptor activity; methionine enkephalin receptor activity
copper import into the mitochondrion (GO:0140636)
Namespace: biological_process
Definition: The process in which copper is transported from the cytosol into the mitochondrial matrix.
positive regulation of pyroptotic inflammatory response (GO:0140639)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of a pyroptotic inflammatory response.
Synonyms: positive regulation of pyroptosis
catalytic activity, acting on a nucleic acid (GO:0140640)
Namespace: molecular_function
Definition: Catalytic activity that acts to modify a nucleic acid.
negative regulation of pre-B cell receptor expression (GO:0140646)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells.
obsolete mitochondrial proliferation (GO:0140655)
Namespace: biological_process
Definition: OBSOLETE. The multiplication of mitochondria, resulting in the expansion of the number of mitochondria within a cell.
Comment: This term was obsoleted because it was not clearly defined and usage has been inconsistent.
regulation of oxytocin production (GO:0140667)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of production of oxytocin.