LiteFold/GO huggingface dataset:
phosphatidylethanolamine flippase activity (GO:0090555)
Namespace: molecular_function
Definition: Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
Synonyms: ATP-dependent phosphatidylethanolamine transporter activity; ATPase-coupled phosphatidylethanolamine transporter activity; phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet); phosphatidylethanolamine-translocating ATPase activity
Comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaflet of a membrane).
protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity (GO:0090566)
Namespace: molecular_function
Definition: Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in).
RNA polymerase II transcription repressor complex (GO:0090571)
Namespace: cellular_component
Definition: A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter.
RNA polymerase V transcription repressor complex (GO:0090574)
Namespace: cellular_component
Definition: A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter.
RNA polymerase V transcription regulator complex (GO:0090578)
Namespace: cellular_component
Definition: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V.
Synonyms: RNA polymerase V transcription factor complex
protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity (GO:0090583)
Namespace: molecular_function
Definition: Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in).
protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity (GO:0090591)
Namespace: molecular_function
Definition: Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in).
L-lysine N6-acetyltransferase activity (GO:0090595)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + L-lysine = CoA + H+ + N6-acetyl-L-lysine.
Synonyms: acetyl-CoA:L-lysine N6-acetyltransferase
sensory organ morphogenesis (GO:0090596)
Namespace: biological_process
Definition: Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
telomerase RNA localization (GO:0090672)
Namespace: biological_process
Definition: Any process in which telomerase RNA is transported to, or maintained in, a specific location.
GPCR taste receptor activity (GO:0090681)
Namespace: molecular_function
Definition: A G protein-coupled receptor activity that is responsible for the sense of taste.
Synonyms: G-protein coupled taste receptor activity; G-protein-coupled taste receptor activity
post-embryonic plant morphogenesis (GO:0090698)
Namespace: biological_process
Definition: The process, occurring after plant embryonic development, by which anatomical structures are generated and organized.
phosphomevalonate decarboxylase activity (GO:0090710)
Namespace: molecular_function
Definition: Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate.
immunological memory formation process (GO:0090715)
Namespace: biological_process
Definition: Any immunological memory process that can contribute to the formation of immunological memory.
adaptive immune effector response (GO:0090718)
Namespace: biological_process
Definition: An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response.
primary adaptive immune response (GO:0090720)
Namespace: biological_process
Definition: An adaptive immune response against an antigen not previously encountered by immune system.
receptor-receptor interaction (GO:0090722)
Namespace: molecular_function
Definition: The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.
Synonyms: hetero-receptor complex formation
site of DNA damage (GO:0090734)
Namespace: cellular_component
Definition: A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
telomere maintenance via telomere trimming (GO:0090737)
Namespace: biological_process
Definition: A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication.
adipokinetic hormone receptor binding (GO:0097005)
Namespace: molecular_function
Definition: Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.
Synonyms: AKH receptor binding
L27 domain binding (GO:0097016)
Namespace: molecular_function
Definition: Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.
ubiquitin-protein transferase activator activity (GO:0097027)
Namespace: molecular_function
Definition: Binds to and increases the activity of a ubiquitin-protein transferase.
phenolic phthiocerol biosynthetic process (GO:0097041)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position.
Synonyms: phenolic phthiocerol anabolism; phenolic phthiocerol biosynthesis; phenolic phthiocerol formation; phenolic phthiocerol synthesis; phenolphthiocerol biosynthesis
obsolete histone H3-K56 acetylation (GO:0097043)
Namespace: biological_process
Definition: OBSOLETE. The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone.
Comment: This term was obsoleted because it represents a molecular function.
agmatine biosynthetic process (GO:0097055)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase.
Synonyms: agmatine anabolism; agmatine biosynthesis; agmatine formation; agmatine synthesis
response to thyroxine (GO:0097068)
Namespace: biological_process
Definition: A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.
Synonyms: response to T4; response to T4 stimulus; response to thyroxine stimulus
interferon regulatory factor complex (GO:0097071)
Namespace: cellular_component
Definition: A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit.
Synonyms: IRF complex
vascular associated smooth muscle cell development (GO:0097084)
Namespace: biological_process
Definition: The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
Synonyms: vascular smooth muscle cell development
obsolete polyacyltrehalose metabolic process (GO:0097092)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid.
Synonyms: polyacyltrehalose metabolism
Comment: This term was obsoleted because it is an unnecessary grouping class.
craniofacial suture morphogenesis (GO:0097094)
Namespace: biological_process
Definition: The process in which any suture between cranial and/or facial bones is generated and organized.
postsynaptic membrane assembly (GO:0097104)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
Synonyms: post-synaptic membrane assembly
postsynaptic density assembly (GO:0097107)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
Synonyms: post synaptic density assembly; post-synaptic density assembly; PSD assembly
BIM-BCL-2 complex (GO:0097141)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
PUMA-BCL-2 complex (GO:0097142)
Namespace: cellular_component
Definition: A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.
positive regulation of inhibitory postsynaptic potential (GO:0097151)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
Synonyms: positive regulation of inhibitory post-synaptic membrane potential; positive regulation of IPSP
execution phase of apoptosis (GO:0097194)
Namespace: biological_process
Definition: A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Synonyms: apoptosis; execution phase of apoptotic process
tetraspanin-enriched microdomain (GO:0097197)
Namespace: cellular_component
Definition: A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities.
Synonyms: membrane tetraspanin-enriched microdomain; TEM
obsolete cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097199)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.
Synonyms: activator caspase activity; apical caspase activity; cysteine-type endopeptidase activity involved in apoptotic signalling pathway; initiator caspase activity
Comment: Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases.\nThe reason for obsoletion is that this term represents a GO-CAM model.
obsolete activation of cysteine-type endopeptidase activity (GO:0097202)
Namespace: biological_process
Definition: OBSOLETE. Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.
Synonyms: activation of caspase activity; activation of metacaspase activity
Comment: This term should be used to annotate gene products within the context of cellular processes other than apoptotic cell death (e.g., cell cycle arrest). To annotate gene products involved in activation of cysteine-type endopeptidases where the activation results in apoptotic process, please use the more granular term GO:0006919.\nThe reason for obsoletion is that this term represents regulation of a molecular function
positive regulation of lysosomal membrane permeability (GO:0097214)
Namespace: biological_process
Definition: Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.
Synonyms: positive regulation of lysosome membrane permeability
guanosine tetraphosphate binding (GO:0097216)
Namespace: molecular_function
Definition: Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions.
Synonyms: 5'-ppGpp-3' binding
sperm mitochondrial sheath (GO:0097226)
Namespace: cellular_component
Definition: The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.
flavanol binding (GO:0097245)
Namespace: molecular_function
Definition: Binding to a flavanol.
Synonyms: flavan-3-ol binding
epigallocatechin 3-gallate binding (GO:0097247)
Namespace: molecular_function
Definition: Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin.
Synonyms: catechin gallate binding; EGCG binding
20-aldehyde-leukotriene B4 20-monooxygenase activity (GO:0097259)
Namespace: molecular_function
Definition: Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase].
obsolete lipoprotein biosynthetic process via diacylglyceryl transfer (GO:0097302)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex.
Synonyms: lipoprotein biosynthesis (diacylglyceryl transfer)
Comment: The reason for obsoletion is that this term represents a molecular function.
obsolete lipoprotein biosynthetic process via N-acyl transfer (GO:0097303)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex.
Synonyms: lipoprotein biosynthesis (N-acyl transfer)
Comment: The reason for obsoletion is that this term represents a molecular function.
cellular response to alcohol (GO:0097306)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.
plasma membrane tubulation (GO:0097320)
Namespace: biological_process
Definition: A membrane tubulation process occurring in a plasma membrane.
Synonyms: membrane tubulation; vesicle scission
melanocyte migration (GO:0097324)
Namespace: biological_process
Definition: The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
response to 5-fluoro-2'-deoxyuridine (GO:0097330)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
centrolateral pattern formation (GO:0097353)
Namespace: biological_process
Definition: The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment.
Synonyms: mediolateral pattern formation
synaptic vesicle lumen acidification (GO:0097401)
Namespace: biological_process
Definition: The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.
Synonyms: synaptic vesicle lumen pH reduction; synaptic vesicle proton loading
cellular response to raffinose (GO:0097403)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus.
classical Lewy body (GO:0097414)
Namespace: cellular_component
Definition: Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils.
Synonyms: brainstem Lewy body
amino acid ligation activity by nonribosomal peptide synthase (GO:0097429)
Namespace: molecular_function
Definition: Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase.
mitotic spindle pole (GO:0097431)
Namespace: cellular_component
Definition: Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
hippocampal pyramidal neuron differentiation (GO:0097432)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus.
basal dendrite (GO:0097441)
Namespace: cellular_component
Definition: A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon.
Synonyms: basilar dendrite
dendritic tree (GO:0097447)
Namespace: cellular_component
Definition: The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
spine mat (GO:0097448)
Namespace: cellular_component
Definition: A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma.
glial limiting end-foot (GO:0097451)
Namespace: cellular_component
Definition: Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans.
Synonyms: glial limiting endfoot
Schwann cell microvillus (GO:0097454)
Namespace: cellular_component
Definition: Small finger-like extension of a Schwann cell that contacts the nodal membrane.
mossy fiber rosette (GO:0097471)
Namespace: cellular_component
Definition: A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.
Synonyms: cerebellar mossy fiber to granule cell synapse
leaflet of membrane bilayer (GO:0097478)
Namespace: cellular_component
Definition: Any of the two layers of lipid molecules that constitute a membrane.
Synonyms: membrane leaflet
dendritic cell dendrite (GO:0097511)
Namespace: cellular_component
Definition: A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.
nucleotide-excision repair, preincision complex (GO:0097520)
Namespace: cellular_component
Definition: A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage.
Synonyms: UvrA(2)-UvrB(2) complex; UvrA(2)B(2) complex; UvrB dimer
lymphoid lineage cell migration (GO:0097534)
Namespace: biological_process
Definition: The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.
Synonyms: lymphoid lineage restricted progenitor cell migration
axonemal basal plate (GO:0097541)
Namespace: cellular_component
Definition: Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure.
Synonyms: axoneme basal plate; basal plate