LiteFold/GO huggingface dataset:
zona limitans intrathalamica formation (GO:0022006)
Namespace: biological_process
Definition: The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon.
Synonyms: zli biosynthesis; zli formation
obsolete leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment (GO:0022025)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by the binding of leukemia inhibitory factor to its receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
Synonyms: leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
obsolete epidermal growth factor signaling pathway involved in forebrain neuron fate commitment (GO:0022026)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
Synonyms: epidermal growth factor signalling pathway involved in forebrain neuron fate commitment
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
tangential migration from the subventricular zone to the olfactory bulb (GO:0022028)
Namespace: biological_process
Definition: The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.
Synonyms: rostral migratory stream migration
cell cycle process (GO:0022402)
Namespace: biological_process
Definition: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
negative regulation of cell-cell adhesion (GO:0022408)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
Synonyms: down regulation of cell-cell adhesion; down-regulation of cell-cell adhesion; downregulation of cell-cell adhesion; inhibition of cell-cell adhesion
digestive system process (GO:0022600)
Namespace: biological_process
Definition: A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
mammalian oogenesis stage (GO:0022605)
Namespace: biological_process
Definition: A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell.
Synonyms: mammalian oogenesis process
DNA strand elongation (GO:0022616)
Namespace: biological_process
Definition: The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.
chloroplast large ribosomal subunit (GO:0022628)
Namespace: cellular_component
Definition: The large subunit of a ribosome contained within a chloroplast.
Synonyms: chloroplast ribosomal large subunit complex; chloroplast ribosomal LSU complex
mobile ion carrier activity (GO:0022809)
Namespace: molecular_function
Definition: Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane.
Synonyms: ionophore
obsolete large uncharged polar molecule transmembrane transporter activity (GO:0022815)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other.
Synonyms: large uncharged polar molecule transmembrane transporter activity
Comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term.
glutamate-gated calcium ion channel activity (GO:0022849)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
obsolete positive regulation of initiation of T cell receptor signaling (GO:0023011)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling.
Synonyms: positive regulation of initiation of T cell receptor signaling; positive regulation of initiation of T cell receptor signalling
Comment: This term was made obsolete because the meaning of the term is ambiguous.
termination of signal transduction (GO:0023021)
Namespace: biological_process
Definition: The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.
Comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn.
obsolete signal initiation by protein/peptide mediator (GO:0023049)
Namespace: biological_process
Definition: OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor.
Synonyms: signal initiation by protein/peptide mediator
Comment: This term was made obsolete because the meaning of the term is ambiguous.
obsolete signal transmission via transcytosis (GO:0023062)
Namespace: biological_process
Definition: OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
Synonyms: signal transmission via transcytosis
Comment: This term was made obsolete because the meaning of the term is ambiguous.
obsolete signal transmission via lymphatic system (GO:0023067)
Namespace: biological_process
Definition: OBSOLETE. The process in which a signal is conveyed via the lymphatic system.
Synonyms: signal transmission via lymphatic system
Comment: This term was made obsolete because the meaning of the term is ambiguous.
extracellular matrix structural constituent conferring tensile strength (GO:0030020)
Namespace: molecular_function
Definition: A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.
Synonyms: core extracellular matrix; core matrisome
Comment: Extracellular matrix collagen proteins may be annotated to this term. PMID:29632050, PMID:24443019
extracellular matrix structural constituent conferring compression resistance (GO:0030021)
Namespace: molecular_function
Definition: A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.
Synonyms: core extracellular matrix; core matrisome
Comment: Extracellular matrix proteoglycans may be annotated to this term. PMID:8346704
obsolete adhesive extracellular matrix constituent (GO:0030022)
Namespace: molecular_function
Definition: OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix.
Synonyms: adhesive extracellular matrix constituent
Comment: This term was made obsolete because it does not represent a molecular function.
cell projection organization (GO:0030030)
Namespace: biological_process
Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
Synonyms: cell projection organisation; cell projection organization and biogenesis; cell surface structure organization and biogenesis
microvillus assembly (GO:0030033)
Namespace: biological_process
Definition: Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
Synonyms: microvillus biogenesis
actin modification (GO:0030047)
Namespace: biological_process
Definition: Covalent modification of an actin molecule.
L-malate dehydrogenase (NAD+) activity (GO:0030060)
Namespace: molecular_function
Definition: Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
Synonyms: (S)-malate:NAD+ oxidoreductase activity; L-malate-NAD+ oxidoreductase activity; malate (NAD) dehydrogenase activity; malic acid dehydrogenase activity; malic dehydrogenase activity; MDH; NAD-dependent malate dehydrogenase activity; NAD-dependent malic dehydrogenase activity; NAD-L-malate dehydrogenase activity; NAD-linked malate dehydrogenase activity; NAD-malate dehydrogenase activity; NAD-malic dehydrogenase activity; NAD-specific malate dehydrogenase activity
obsolete lytic viral life cycle (GO:0030068)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: lytic viral life cycle
Comment: This term was made obsolete because more specific terms were created.
B875 antenna complex (GO:0030080)
Namespace: cellular_component
Definition: Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm.
Synonyms: LH1 complex; light harvesting complex I
obsolete PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex (GO:0030086)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex
Comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
obsolete PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex (GO:0030087)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex
Comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
protein repair (GO:0030091)
Namespace: biological_process
Definition: The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
chloroplast photosystem I (GO:0030093)
Namespace: cellular_component
Definition: Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana.
chloroplast photosystem II (GO:0030095)
Namespace: cellular_component
Definition: An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.
HLA-A specific inhibitory MHC class I receptor activity (GO:0030107)
Namespace: molecular_function
Definition: Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.
regulation of Wnt signaling pathway (GO:0030111)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
Synonyms: regulation of frizzled signaling pathway; regulation of frizzled signalling pathway; regulation of Wnt receptor signaling pathway; regulation of Wnt receptor signalling pathway; regulation of Wnt-activated signaling pathway
clathrin coat (GO:0030118)
Namespace: cellular_component
Definition: A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.
Synonyms: clathrin cage
bacteriocin immunity (GO:0030153)
Namespace: biological_process
Definition: A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.
voltage-gated proton channel activity (GO:0030171)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: voltage gated proton channel activity; voltage-dependent proton channel activity
neutrophil differentiation (GO:0030223)
Namespace: biological_process
Definition: The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.
Synonyms: neutrophil cell differentiation; neutrophil granulocyte differentiation; neutrophil granulocytopoiesis
guanylate cyclase regulator activity (GO:0030249)
Namespace: molecular_function
Definition: Modulates the activity of guanylate cyclase.
melanin-concentrating hormone receptor activity (GO:0030273)
Namespace: molecular_function
Definition: Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity.
Synonyms: MCH receptor
negative regulation of ossification (GO:0030279)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms: down regulation of ossification; down-regulation of ossification; downregulation of ossification; inhibition of ossification; negative regulation of bone biosynthesis; negative regulation of bone formation
positive regulation of cell growth (GO:0030307)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, extent or direction of cell growth.
Synonyms: activation of cell growth; stimulation of cell growth; up regulation of cell growth; up-regulation of cell growth; upregulation of cell growth
negative regulation of cell growth (GO:0030308)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
Synonyms: down regulation of cell growth; down-regulation of cell growth; downregulation of cell growth; inhibition of cell growth
embryonic limb morphogenesis (GO:0030326)
Namespace: biological_process
Definition: The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
obsolete cleavage stimulation factor activity (GO:0030365)
Namespace: molecular_function
Definition: OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide.
Synonyms: cleavage stimulation factor activity; CstF
Comment: This term was made obsolete because it describes a cellular component.
interleukin-17 receptor binding (GO:0030367)
Namespace: molecular_function
Definition: Binding to an interleukin-17 receptor.
Synonyms: IL-17; interleukin-17 receptor ligand
urokinase plasminogen activator receptor activity (GO:0030377)
Namespace: molecular_function
Definition: Combining with the urokinase plasminogen activator to initiate a change in cell activity.
Synonyms: U-plasminogen activator receptor activity; uPAR; urokinase plasminogen activator receptor
sporulation resulting in formation of a cellular spore (GO:0030435)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction.
Synonyms: cellular spore formation by sporulation; spore biosynthesis; spore differentiation; spore formation
Comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo.
obsolete microtubule depolymerization during nuclear congression (GO:0030444)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: microtubule depolymerization during nuclear congression
Comment: This term was made obsolete because the entire branch of the ontology was changed.
regulation of complement activation, alternative pathway (GO:0030451)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation.
Synonyms: regulation of complement cascade, alternative pathway
obsolete activation of MAPKKK (mating sensu Fungi) (GO:0030458)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: activation of MAPKKK (mating sensu Fungi)
Comment: This term was made obsolete because it is a gene product specific term.
obsolete aging dependent sterility (sensu Fungi) (GO:0030464)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: aging dependent sterility (sensu Fungi)
Comment: This term was made obsolete because it reflected a trait or phenotype.
negative regulation of bone mineralization (GO:0030502)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
Synonyms: down regulation of bone mineralization; down-regulation of bone mineralization; downregulation of bone mineralization; inhibition of bone mineralization
regulation of BMP signaling pathway (GO:0030510)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
Synonyms: regulation of BMP receptor signaling pathway; regulation of BMP signalling pathway; regulation of bone morphogenetic protein signaling pathway; regulation of bone morphogenetic protein signalling pathway; regulation of decapentaplegic receptor signaling pathway; regulation of decapentaplegic receptor signalling pathway; regulation of decapentaplegic signaling pathway
nuclear receptor-mediated steroid hormone signaling pathway (GO:0030518)
Namespace: biological_process
Definition: A nuclear receptor-mediated signaling pathway initiated by a steroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms: intracellular steroid hormone receptor signaling pathway; steroid hormone receptor signaling pathway; steroid hormone receptor signalling pathway
female genitalia development (GO:0030540)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure.
Synonyms: female genital development
acetylcholine receptor inhibitor activity (GO:0030550)
Namespace: molecular_function
Definition: Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.
cGMP binding (GO:0030553)
Namespace: molecular_function
Definition: Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
Synonyms: 3',5' cGMP binding; 3',5'-cGMP binding; cyclic GMP binding
snRNA pseudouridylation guide activity (GO:0030565)
Namespace: molecular_function
Definition: Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
snRNA modification guide activity (GO:0030566)
Namespace: molecular_function
Definition: Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue.
Comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
obsolete chymotrypsin inhibitor activity (GO:0030569)
Namespace: molecular_function
Definition: OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin.
Synonyms: chymotrypsin inhibitor activity
Comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term.
first cell cycle pseudocleavage (GO:0030590)
Namespace: biological_process
Definition: A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms.
feruloyl esterase activity (GO:0030600)
Namespace: molecular_function
Definition: Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide.
Synonyms: 4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity; cinnAE; cinnamoyl ester hydrolase activity; FAE-I; FAE-II; FAE-III; FAEA; ferulic acid esterase activity; hemicellulase accessory; hydroxycinnamoyl esterase activity
oxaloacetase activity (GO:0030603)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + oxaloacetate = acetate + H+ + oxalate.
Synonyms: oxalacetic hydrolase activity; oxaloacetate acetylhydrolase activity
oxidoreductase activity, acting on phosphorus or arsenic in donors (GO:0030613)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
Synonyms: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors
oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor (GO:0030614)
Namespace: molecular_function
Definition: Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide.
Synonyms: oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor
intracellular sulfate ion homeostasis (GO:0030642)
Namespace: biological_process
Definition: A homeostatic process involved in the maintenance of a steady state level of sulfate ions within a cell.
Synonyms: cellular sulfate ion homeostasis; sulphate ion homeostasis
aminoglycoside antibiotic catabolic process (GO:0030649)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.
Synonyms: aminoglycoside antibiotic breakdown; aminoglycoside antibiotic catabolism; aminoglycoside antibiotic degradation
cytoplasmic vesicle membrane (GO:0030659)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a cytoplasmic vesicle.
endocytic vesicle membrane (GO:0030666)
Namespace: cellular_component
Definition: The lipid bilayer surrounding an endocytic vesicle.