LiteFold/GO huggingface dataset:
ventral spinal cord interneuron differentiation (GO:0021514)
Namespace: biological_process
Definition: The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.
cell differentiation in spinal cord (GO:0021515)
Namespace: biological_process
Definition: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.
spinal cord oligodendrocyte cell differentiation (GO:0021529)
Namespace: biological_process
Definition: The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.
corpus callosum morphogenesis (GO:0021540)
Namespace: biological_process
Definition: The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres.
ammon gyrus development (GO:0021541)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.
Synonyms: Ammon's horn development; cornu ammonis development
pallium development (GO:0021543)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.
pons development (GO:0021548)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.
cerebellum maturation (GO:0021590)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
cranial nerve structural organization (GO:0021604)
Namespace: biological_process
Definition: The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
Synonyms: cranial nerve structural organisation
accessory nerve structural organization (GO:0021609)
Namespace: biological_process
Definition: The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.
Synonyms: accessory nerve structural organisation; CN XI structural organization
oculomotor nerve maturation (GO:0021625)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
Synonyms: CN III maturation
olfactory nerve maturation (GO:0021630)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
Synonyms: CN I maturation
optic nerve morphogenesis (GO:0021631)
Namespace: biological_process
Definition: The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
Synonyms: CN II morphogenesis
optic nerve structural organization (GO:0021633)
Namespace: biological_process
Definition: The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
Synonyms: CN II structural organization; optic nerve structural organisation
trigeminal nerve morphogenesis (GO:0021636)
Namespace: biological_process
Definition: The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
Synonyms: CN V morphogenesis
vagus nerve structural organization (GO:0021645)
Namespace: biological_process
Definition: The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.
Synonyms: CN X structural organization; vagus nerve structural organisation
rhombomere 2 structural organization (GO:0021656)
Namespace: biological_process
Definition: The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.
Synonyms: rhombomere 2 structural organisation
rhombomere 2 formation (GO:0021657)
Namespace: biological_process
Definition: The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
rhombomere 8 formation (GO:0021677)
Namespace: biological_process
Definition: The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
third ventricle development (GO:0021678)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina.
cerebellar molecular layer maturation (GO:0021690)
Namespace: biological_process
Definition: A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
cerebellar Purkinje cell layer formation (GO:0021694)
Namespace: biological_process
Definition: The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
cerebellar cortex structural organization (GO:0021698)
Namespace: biological_process
Definition: The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
Synonyms: cerebellar cortex structural organisation
cerebellar Golgi cell differentiation (GO:0021701)
Namespace: biological_process
Definition: The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
locus ceruleus development (GO:0021703)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
Synonyms: locus caeruleus development; locus coeruleus development
candelabrum cell differentiation (GO:0021712)
Namespace: biological_process
Definition: The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.
nucleus ambiguus development (GO:0021745)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure.
cochlear nucleus development (GO:0021747)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.
hippocampus development (GO:0021766)
Namespace: biological_process
Definition: The progression of the hippocampus over time from its initial formation until its mature state.
Synonyms: hippocampal formation development
nucleus accumbens development (GO:0021768)
Namespace: biological_process
Definition: The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.
Synonyms: accumbens nucleus development; ventral striatum development
smoothened signaling pathway involved in ventral spinal cord interneuron specification (GO:0021775)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
Synonyms: hedgehog signaling pathway involved in ventral spinal cord interneuron specification; hh signaling pathway involved in ventral spinal cord interneuron specification; smoothened signalling pathway involved in ventral spinal cord interneuron specification
glial cell development (GO:0021782)
Namespace: biological_process
Definition: The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
extension of leading cell process to pial surface (GO:0021803)
Namespace: biological_process
Definition: The extension of a long process to the pial surface as a cell leaves the ventricular zone.
layer formation in cerebral cortex (GO:0021819)
Namespace: biological_process
Definition: The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
Synonyms: cerebral cortex lamination
obsolete cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions (GO:0021832)
Namespace: biological_process
Definition: OBSOLETE. The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
hypothalamus development (GO:0021854)
Namespace: biological_process
Definition: The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
obsolete asymmetric radial glial cell division in forebrain (GO:0021866)
Namespace: biological_process
Definition: OBSOLETE. The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type.
Comment: This term was obsoleted because it represents a GO-CAM model.
Wnt signaling pathway involved in forebrain neuroblast division (GO:0021874)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.
Synonyms: Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signalling pathway in forebrain neuroblast division; Wnt-activated signaling pathway involved in forebrain neuroblast division
forebrain neuron development (GO:0021884)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
hypothalamus gonadotrophin-releasing hormone neuron fate commitment (GO:0021887)
Namespace: biological_process
Definition: The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone.
Synonyms: hypothalamus gonadotropin-releasing hormone neuron fate commitment
rostrocaudal neural tube patterning (GO:0021903)
Namespace: biological_process
Definition: The process in which the neural tube is divided into specific regions along the rostrocaudal axis.
Synonyms: anterior-posterior neural tube patterning
obsolete regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification (GO:0021913)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord.
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning (GO:0021914)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.
Synonyms: down regulation of smoothened signaling pathway in ventral spinal cord patterning; down-regulation of smoothened signaling pathway in ventral spinal cord patterning; downregulation of smoothened signaling pathway in ventral spinal cord patterning; inhibition of smoothened signaling pathway in ventral spinal cord patterning; negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning; negative regulation of hh signaling pathway involved in ventral spinal cord patterning; negative regulation of smoothened signalling pathway in ventral spinal cord patterning
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
neural tube development (GO:0021915)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
negative regulation of cerebellar granule cell precursor proliferation (GO:0021941)
Namespace: biological_process
Definition: The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation.
Synonyms: down regulation of granule cell precursor proliferation; down-regulation of granule cell precursor proliferation; downregulation of granule cell precursor proliferation; inhibition of granule cell precursor proliferation
central nervous system interneuron axonogenesis (GO:0021956)
Namespace: biological_process
Definition: Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.
anterior commissure morphogenesis (GO:0021960)
Namespace: biological_process
Definition: Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.
corticospinal neuron axon decussation (GO:0021973)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side.
tectospinal tract morphogenesis (GO:0021977)
Namespace: biological_process
Definition: Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord.
pineal gland development (GO:0021982)
Namespace: biological_process
Definition: The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms.
Synonyms: epiphysis development
neural plate formation (GO:0021990)
Namespace: biological_process
Definition: The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.