LiteFold/GO huggingface dataset:
negative regulation of interleukin-10 production (GO:0032693)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
Synonyms: down regulation of interleukin-10 production; down-regulation of interleukin-10 production; downregulation of interleukin-10 production; inhibition of interleukin-10 production; negative regulation of IL-10 production; negative regulation of interleukin-10 biosynthetic process; negative regulation of interleukin-10 secretion
negative regulation of interleukin-6 production (GO:0032715)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
Synonyms: down regulation of interleukin-6 production; down-regulation of interleukin-6 production; downregulation of interleukin-6 production; inhibition of interleukin-6 production; negative regulation of IL-6 production; negative regulation of interleukin-6 biosynthetic process; negative regulation of interleukin-6 secretion
negative regulation of TRAIL production (GO:0032719)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production.
Synonyms: down regulation of TRAIL production; down-regulation of TRAIL production; downregulation of TRAIL production; inhibition of TRAIL production; negative regulation of TRAIL biosynthetic process
negative regulation of lymphotoxin A production (GO:0032721)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production.
Synonyms: down regulation of lymphotoxin A production; down-regulation of lymphotoxin A production; downregulation of lymphotoxin A production; inhibition of lymphotoxin A production; negative regulation of LTA production; negative regulation of lymphotoxin A biosynthetic process; negative regulation of lymphotoxin-alpha production; negative regulation of TNF-beta production; negative regulation of tumor necrosis factor-beta production
positive regulation of interleukin-10 production (GO:0032733)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
Synonyms: activation of interleukin-10 production; positive regulation of IL-10 production; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-10 secretion; stimulation of interleukin-10 production; up regulation of interleukin-10 production; up-regulation of interleukin-10 production; upregulation of interleukin-10 production
positive regulation of interleukin-24 production (GO:0032748)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate, or extent of interleukin-24 production.
Synonyms: activation of interleukin-24 production; positive regulation of IL-24 production; positive regulation of interleukin-24 biosynthetic process; stimulation of interleukin-24 production; up regulation of interleukin-24 production; up-regulation of interleukin-24 production; upregulation of interleukin-24 production
positive regulation of tumor necrosis factor production (GO:0032760)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
Synonyms: activation of tumor necrosis factor production; positive regulation of cachectin secretion; positive regulation of TNF production; positive regulation of TNF secretion; positive regulation of TNF-alpha production; positive regulation of tumor necrosis factor biosynthesis; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor formation; positive regulation of tumor necrosis factor secretion; positive regulation of tumor necrosis factor-alpha production; stimulation of tumor necrosis factor production; up regulation of tumor necrosis factor production; up-regulation of tumor necrosis factor production; upregulation of tumor necrosis factor production
Comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
regulation of mast cell cytokine production (GO:0032763)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of mast cell cytokine production.
obsolete regulation of tyrosinase activity (GO:0032771)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the activity of a tyrosinase enzyme.
Synonyms: regulation of monophenol monooxygenase activity; regulation of monophenol oxygenase activity
Comment: This term was obsoleted because it represents a molecular function.
P-type cobalt transporter activity (GO:0032778)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Co2+(out) = ADP + phosphate + Co2+(in).
Synonyms: ATP-dependent cobalt transmembrane transporter activity; ATPase-coupled cobalt transmembrane transporter activity; cobalt porter activity; cobalt transporting ATPase activity; cobalt-transporting ATPase activity
negative regulation of DNA-templated transcription, elongation (GO:0032785)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
Synonyms: down regulation of RNA elongation; down-regulation of RNA elongation; downregulation of RNA elongation; inhibition of RNA elongation; negative regulation of DNA-dependent transcription, elongation; negative regulation of transcription elongation; negative regulation of transcription elongation, DNA-dependent; negative regulation of transcriptional elongation; negative transcription elongation regulator activity
unsaturated monocarboxylic acid metabolic process (GO:0032789)
Namespace: biological_process
Definition: The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds.
Synonyms: unsaturated monocarboxylate metabolic process; unsaturated monocarboxylic acid metabolism
low-density lipoprotein particle receptor catabolic process (GO:0032802)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Synonyms: LDL receptor breakdown; LDL receptor catabolic process; LDL receptor catabolism; LDL receptor degradation; low-density lipoprotein receptor breakdown; low-density lipoprotein receptor catabolic process; low-density lipoprotein receptor catabolism; low-density lipoprotein receptor degradation
obsolete positive regulation of natural killer cell differentiation involved in immune response (GO:0032828)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response.
Synonyms: activation of natural killer cell differentiation during immune response; positive regulation of natural killer cell development involved in immune response; positive regulation of natural killer cell differentiation during immune response; positive regulation of NK cell differentiation during immune response; stimulation of natural killer cell differentiation during immune response; up regulation of natural killer cell differentiation during immune response; up-regulation of natural killer cell differentiation during immune response; upregulation of natural killer cell differentiation during immune response
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
L-arabinose reductase (NADPH) activity (GO:0032867)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+.
Synonyms: arabinose reductase activity; arabinose:NADP reductase activity; L-arabinose:NADP reductase activity
regulation of polysaccharide biosynthetic process (GO:0032885)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
regulation of vacuole fusion, non-autophagic (GO:0032889)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole.
regulation of organic acid transport (GO:0032890)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of neurotrophin production (GO:0032900)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin.
Synonyms: down regulation of neurotrophin production; down-regulation of neurotrophin production; downregulation of neurotrophin production; inhibition of neurotrophin production
negative regulation of transforming growth factor beta2 production (GO:0032912)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2.
Synonyms: down regulation of transforming growth factor-beta2 production; down-regulation of transforming growth factor-beta2 production; downregulation of transforming growth factor-beta2 production; inhibition of transforming growth factor-beta2 production; negative regulation of TGF-B2 production; negative regulation of TGFB2 production; negative regulation of transforming growth factor-beta2 production
secretion by cell (GO:0032940)
Namespace: biological_process
Definition: The controlled release of a substance by a cell.
Synonyms: cellular secretion
regulation of beta-glucan biosynthetic process (GO:0032951)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans.
Synonyms: regulation of beta-glucan anabolism; regulation of beta-glucan biosynthesis; regulation of beta-glucan formation; regulation of beta-glucan synthesis
inositol trisphosphate metabolic process (GO:0032957)
Namespace: biological_process
Definition: The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
Synonyms: inositol trisphosphate metabolism; IP3 metabolic process; IP3 metabolism; myo-inositol trisphosphate metabolic process
collagen metabolic process (GO:0032963)
Namespace: biological_process
Definition: The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
Synonyms: collagen metabolism
positive regulation of collagen biosynthetic process (GO:0032967)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
Synonyms: positive regulation of collagen anabolism; positive regulation of collagen biosynthesis; positive regulation of collagen formation; positive regulation of collagen synthesis
regulation of actin filament-based process (GO:0032970)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.
amino acid export across plasma membrane (GO:0032973)
Namespace: biological_process
Definition: The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.
Synonyms: amino acid efflux; amino acid export; amino acid transmembrane export
amino acid transmembrane import into vacuole (GO:0032975)
Namespace: biological_process
Definition: The directed movement of amino acids into the vacuole across the vacuolar membrane.
Synonyms: vacuolar amino acid import
myosin filament (GO:0032982)
Namespace: cellular_component
Definition: A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.
Synonyms: myosin thick filament; thick filament
protein-lipid complex disassembly (GO:0032987)
Namespace: biological_process
Definition: The disaggregation of a protein-lipid complex into its constituent components.
protein-RNA complex disassembly (GO:0032988)
Namespace: biological_process
Definition: The disaggregation of a protein-RNA complex into its constituent components.
Synonyms: ribonucleoprotein complex disassembly; RNA-protein complex disassembly; RNP complex disassembly
protein-DNA complex (GO:0032993)
Namespace: cellular_component
Definition: A macromolecular complex containing both protein and DNA molecules.
Synonyms: DNA-protein complex
Comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here.
Fc-epsilon receptor I complex (GO:0032998)
Namespace: cellular_component
Definition: A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.
Synonyms: FceRI complex; IgE receptor complex; immunoglobulin E receptor complex
tetrapyrrole catabolic process (GO:0033015)
Namespace: biological_process
Definition: The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
Synonyms: tetrapyrrole breakdown; tetrapyrrole catabolism; tetrapyrrole degradation
obsolete 5-hydroxyvalerate dehydrogenase activity (GO:0033019)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH.
Comment: This term was obsoleted because it is not known to be catalyzed by any gene product or it represents a specific substrate.
mast cell homeostasis (GO:0033023)
Namespace: biological_process
Definition: The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus.
regulation of mast cell apoptotic process (GO:0033025)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.
Synonyms: regulation of mast cell apoptosis
myeloid cell apoptotic process (GO:0033028)
Namespace: biological_process
Definition: Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
Synonyms: apoptosis of myeloid cells; myeloid cell apoptosis
polysaccharide localization (GO:0033037)
Namespace: biological_process
Definition: Any process in which a polysaccharide is transported to, or maintained in, a specific location.
Synonyms: polysaccharide localisation
ansamycin biosynthetic process (GO:0033070)
Namespace: biological_process
Definition: The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.
Synonyms: ansamycin anabolism; ansamycin biosynthesis; ansamycin formation; ansamycin synthesis
immature T cell proliferation (GO:0033079)
Namespace: biological_process
Definition: The expansion of an immature T cell population by cell division.
regulation of immature T cell proliferation in thymus (GO:0033084)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus.
Synonyms: regulation of thymic T cell proliferation; regulation of thymocyte cell proliferation; regulation of thymocyte proliferation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
negative regulation of T cell differentiation in thymus (GO:0033085)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.
Synonyms: negative regulation of T cell development in thymus; negative regulation of thymic T cell differentiation; negative regulation of thymocyte cell differentiation; negative regulation of thymocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
protein secretion by the type VI secretion system (GO:0033103)
Namespace: biological_process
Definition: The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
Synonyms: protein secretion by the T6SS; protein secretion by the type VI protein secretion system; type VI protein secretion system
Comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'.
type VI protein secretion system complex (GO:0033104)
Namespace: cellular_component
Definition: A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.
Synonyms: T6SS complex
cis-Golgi network membrane (GO:0033106)
Namespace: cellular_component
Definition: The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.
Synonyms: cis Golgi network membrane; Golgi cis face membrane
cyanelle thylakoid membrane (GO:0033115)
Namespace: cellular_component
Definition: The lipid bilayer membrane of any thylakoid within a cyanelle.
negative regulation of RNA splicing (GO:0033119)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.
regulation of intracellular protein transport (GO:0033157)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
mitogen-activated protein kinase kinase kinase kinase binding (GO:0033161)
Namespace: molecular_function
Definition: Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase.
Synonyms: MAPKKKK binding
obsolete chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) (GO:0033174)
Namespace: cellular_component
Definition: OBSOLETE. The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.
Synonyms: chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)
Comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
dolichol-phosphate-mannose synthase complex (GO:0033185)
Namespace: cellular_component
Definition: A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.
Synonyms: dolichyl-phosphate beta-D-mannosyltransferase complex; DPM synthase complex
tryparedoxin peroxidase activity (GO:0033196)
Namespace: molecular_function
Definition: Catalysis of the reaction: tryparedoxin + H2O2 = tryparedoxin disulfide + H2O.
Synonyms: TXNPx activity
obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity (GO:0033199)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.
Synonyms: inositol heptakisphosphate 4-kinase or 6-kinase activity
Comment: This term was made obsolete because it represents two reactions, and should be two separate terms.
2-aminoethylphosphonate transport (GO:0033223)
Namespace: biological_process
Definition: The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Synonyms: 2-phosphonoethylamine transport; ciliatine transport
carbohydrate export (GO:0033231)
Namespace: biological_process
Definition: The directed movement of carbohydrates out of a cell or organelle.
positive regulation of amine metabolic process (GO:0033240)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.
Synonyms: positive regulation of amine metabolism; positive regulation of cellular amine metabolic process
nuclear DNA replication (GO:0033260)
Namespace: biological_process
Definition: The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
Synonyms: DNA replication during S phase; DNA replication involved in S phase; DNA replication involved in S-phase; nuclear cell cycle DNA replication
CORVET complex (GO:0033263)
Namespace: cellular_component
Definition: A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p.