LiteFold/GO huggingface dataset:
filamentous growth of a unicellular organism (GO:0044180)
Namespace: biological_process
Definition: The process in which a unicellular organism grows in a threadlike, filamentous shape.
obsolete host cell microsome (GO:0044189)
Namespace: cellular_component
Definition: OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g.
Synonyms: host cell microsomal membrane; host cell microsome
Comment: This term was obsoleted because it refers to a cell fractionation experimental result and not a bona fide cellular component.
host cell mitochondrial membrane (GO:0044191)
Namespace: cellular_component
Definition: Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope.
host cell mitochondrial outer membrane (GO:0044193)
Namespace: cellular_component
Definition: The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope.
host cell nuclear membrane (GO:0044200)
Namespace: cellular_component
Definition: Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space.
CTP salvage (GO:0044211)
Namespace: biological_process
Definition: Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis.
Synonyms: CTP biosynthetic process via salvage pathway; cytidine 5'-triphosphate salvage
obsolete other organism (GO:0044215)
Namespace: cellular_component
Definition: OBSOLETE. A secondary organism with which the first organism is interacting.
Comment: This term was obsoleted because it represents an organism, which is outside the scope of GO.
juxtaparanode region of axon (GO:0044224)
Namespace: cellular_component
Definition: A region of an axon near a node of Ranvier that is between the paranode and internode regions.
Synonyms: juxta paranode axon; juxtaparanodal region; juxtaparanode
basal pole of neuron (GO:0044226)
Namespace: cellular_component
Definition: Portion of a neuron cell soma closest to the point where the basilar dendrite emerges.
host cell envelope (GO:0044230)
Namespace: cellular_component
Definition: An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present.
host cell presynaptic membrane (GO:0044231)
Namespace: cellular_component
Definition: A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
Synonyms: host cell pre-synaptic membrane; other organism pre-synaptic membrane; other organism presynaptic membrane
organelle membrane contact site (GO:0044232)
Namespace: cellular_component
Definition: A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.
Synonyms: inter-organelle junction; interorganelle junction; MCS
mitochondria-associated endoplasmic reticulum membrane contact site (GO:0044233)
Namespace: cellular_component
Definition: A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.
Synonyms: endoplasmic reticulum-mitochondrion membrane contact site; ER-mitochondrion membrane contact site; MAM; mitochondria-associated ER membrane; mitochondria-associated membrane; mitochondria-endoplasmic reticulum (ER) contact
obsolete cellular metabolic process (GO:0044237)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances.
Synonyms: cellular metabolism; intermediary metabolism
Comment: The reason for obsoletion is that this term is now redundant with GO:0008152, metabolic process
polysaccharide digestion (GO:0044245)
Namespace: biological_process
Definition: The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.
small molecule biosynthetic process (GO:0044283)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
Synonyms: small molecule biosynthesis
Comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
cell body (GO:0044297)
Namespace: cellular_component
Definition: The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
Synonyms: cell soma
Comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
cellular response to leptin stimulus (GO:0044320)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
retinoic acid-responsive element binding (GO:0044323)
Namespace: molecular_function
Definition: Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind.
Synonyms: RARE binding
obsolete Wnt signaling pathway involved in digestive tract morphogenesis (GO:0044333)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract.
Synonyms: Wnt receptor signaling pathway involved in digestive tract morphogenesis; Wnt receptor signalling pathway involved in digestive tract morphogenesis; Wnt-activated signaling pathway involved in digestive tract morphogenesis
Comment: This term was obsoleted because it represents a GO-CAM model.
canonical Wnt signaling pathway involved in negative regulation of apoptotic process (GO:0044336)
Namespace: biological_process
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process.
Synonyms: canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis; canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process; canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis
macropinosome (GO:0044354)
Namespace: cellular_component
Definition: A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
obsolete negative regulation of voltage-gated potassium channel activity in another organism (GO:0044361)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism.
Synonyms: negative regulation of voltage-gated potassium channel activity in other organism
Comment: This term was obsoleted because it is too general.
obsolete RNA polymerase II complex import to nucleus (GO:0044376)
Namespace: biological_process
Definition: OBSOLETE. The directed movement of the DNA-directed RNA polymerase II core complex from the cytoplasm into the nucleus.
Synonyms: DNA-directed RNA polymerase II core complex import into nucleus; DNA-directed RNA polymerase II core complex localization to nucleus; RNA polymerase II complex import into nucleus; RNA polymerase II complex localisation to nucleus
Comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
obsolete integral to membrane of host cell (GO:0044385)
Namespace: cellular_component
Definition: OBSOLETE. Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell.
Comment: This term was obsoleted because it represents protein topology, not a cellular component.
ubiquitin-like protein conjugating enzyme binding (GO:0044390)
Namespace: molecular_function
Definition: Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme.
Synonyms: E2 protein ligase binding; small protein conjugating enzyme binding
protein malonylation (GO:0044394)
Namespace: biological_process
Definition: The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group.
obsolete growth or development of symbiont on or near host (GO:0044408)
Namespace: biological_process
Definition: OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism.
Synonyms: growth or development of organism on or near host surface; growth or development of symbiont on or near host
obsolete organelle part (GO:0044422)
Namespace: cellular_component
Definition: OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
obsolete nucleolar part (GO:0044452)
Namespace: cellular_component
Definition: OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis.
Synonyms: nucleolus component
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
obsolete cell projection part (GO:0044463)
Namespace: cellular_component
Definition: OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
venom-mediated activation of voltage-gated sodium channel activity (GO:0044494)
Namespace: biological_process
Definition: A process in which an organism initiates, promotes, or enhances the activity of a voltage-gated sodium channel in another organism via the action of a venom.
Synonyms: envenomation resulting in positive regulation of voltage-gated sodium channel activity in another organism; envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism
peptidyl-cystine sulfhydration (GO:0044525)
Namespace: biological_process
Definition: The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide.
S100 protein binding (GO:0044548)
Namespace: molecular_function
Definition: Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.
Synonyms: S100 alpha binding; S100 beta binding; S100 binding
venom-mediated perturbation of ion channel activity (GO:0044560)
Namespace: biological_process
Definition: A process in which an organism alters or subverts the activity of an ion channel in another organism via the action of a venom.
Synonyms: envenomation resulting in modulation of ion channel activity in another organism; envenomation resulting in modulation of ion channel activity in other organism; envenomation resulting in regulation of ion channel activity in other organism
[2Fe-2S] cluster assembly (GO:0044571)
Namespace: biological_process
Definition: The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
Synonyms: 2Fe-2S cluster assembly; [2Fe-2S] cluster biosynthetic process
butyryl-CoA catabolic process to butyrate (GO:0044581)
Namespace: biological_process
Definition: The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate.
Synonyms: butyryl-CoA catabolism to butyrate
pectin binding (GO:0044589)
Namespace: molecular_function
Definition: Binding to pectin.
17-beta-hydroxysteroid dehydrogenase (NAD+) activity (GO:0044594)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+.
AP-5 adaptor complex (GO:0044599)
Namespace: cellular_component
Definition: An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo.
Synonyms: adaptor protein-5 adaptor complex
obsolete peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine (GO:0044608)
Namespace: biological_process
Definition: OBSOLETE. The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester.
Synonyms: peptidyl-threonine esterification
Comment: This term was obsoleted because it represents a molecular function.
obsolete modulation of relaxation of uterine smooth muscle in another organism (GO:0044618)
Namespace: biological_process
Definition: OBSOLETE. The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism.
Synonyms: modulation of relaxation of uterine smooth muscle in other organism; regulation of relaxation of uterine smooth muscle in other organism
Comment: This term was obsoleted because it is too general.
obsolete positive regulation of cell migration in another organism (GO:0044623)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of cell migration in a second organism.
Synonyms: envenomation resulting in positive regulation of cell migration in another organism; envenomation resulting in positive regulation of cell migration in other organism; positive regulation of cell migration in other organism
Comment: This term was obsoleted because it is too general.
obsolete negative regulation of complement activation, lectin pathway in another organism (GO:0044632)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism.
Synonyms: negative regulation of complement activation, lectin pathway in other organism
Comment: This term was obsoleted because it is too specific.
obsolete envenomation resulting in modulation of complement activation, classical pathway in another organism (GO:0044636)
Namespace: biological_process
Definition: OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism.
Synonyms: envenomation resulting in modulation of complement activation, classical pathway in other organism
Comment: This term was obsoleted because it is too specific.
obsolete envenomation resulting in positive regulation of complement activation, classical pathway in another organism (GO:0044638)
Namespace: biological_process
Definition: OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism.
Synonyms: envenomation resulting in positive regulation of complement activation, classical pathway in other organism
Comment: This term was obsoleted because this process does not exist.
obsolete envenomation resulting in modulation of complement activation, lectin pathway in another organism (GO:0044639)
Namespace: biological_process
Definition: OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism.
Synonyms: envenomation resulting in modulation of complement activation, lectin pathway in other organism; envenomation resulting in regulation of complement activation, lectin pathway in other organism
Comment: This term was obsoleted because it is too specific.
obsolete envenomation resulting in positive regulation of complement activation, alternative pathway in another organism (GO:0044643)
Namespace: biological_process
Definition: OBSOLETE. A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism.
Synonyms: envenomation resulting in positive regulation of complement activation, alternative pathway in other organism
Comment: This term was obsoleted because this pathway does not exist.
obsolete modulation of complement activation in another organism (GO:0044645)
Namespace: biological_process
Definition: OBSOLETE. A process that modulates the frequency, rate or extent of complement activation in a different organism.
Synonyms: modulation of complement activation in other organism; regulation of complement activation in other organism
Comment: This term was obsoleted because it is too general ; consider symbiont-mediated suppression of host complement activation ; GO:0042784.
adhesion of symbiont to host epithelial cell (GO:0044651)
Namespace: biological_process
Definition: The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly.
obsolete starch alpha-glucosidase activity (GO:0044654)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: starch + H2O = alpha-D-glucose.
Comment: This term was obsoleted because it represents a specific substrate of alpha-1,4-glucosidase activity ; GO:0004558.
viral release via pore formation in host cell membrane (GO:0044660)
Namespace: biological_process
Definition: The dissemination of mature viral particles from a host cell via the formation by the virus of pores in its host cell membrane.
Synonyms: cytolysis by virus via pore formation in host cell membrane; viral exit by cytolysis via pore formation in host cell membrane; viral release by cytolysis via pore formation in host cell membrane
acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex (GO:0044672)
Namespace: cellular_component
Definition: A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis.
Synonyms: carbon monoxide dehydrogenase; carbon-monoxide:(acceptor) oxidoreductase complex; CO dehydrogenase complex; CO dehydrogenase/acetyl-CoA synthase complex; CODH; CODH/ACS complex
methylthiol:coenzyme M methyltransferase complex (GO:0044680)
Namespace: cellular_component
Definition: A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis.
Synonyms: methylthiol coenzyme M methyl transferase complex; methylthiol:coenzyme M methyl transferase complex; methylthiol:CoM methyltransferase complex
geranylfarnesyl diphosphate synthase activity (GO:0044687)
Namespace: molecular_function
Definition: Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate.
Synonyms: FGPP synthase activity
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity (GO:0044689)
Namespace: molecular_function
Definition: Catalysis of the reaction: 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H+ + L-methionine + NH4+.
Synonyms: FO synthase
obsolete response to stimulus by single organism (GO:0044701)
Namespace: biological_process
Definition: OBSOLETE. A response to a stimulus that involves only one organism.
Synonyms: response to stimulus by single organism
Comment: This term was made obsolete because we decided that all responses are single-organism.
8-hydroxy-dADP phosphatase activity (GO:0044717)
Namespace: molecular_function
Definition: Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate.
hemi-methylated DNA-binding (GO:0044729)
Namespace: molecular_function
Definition: Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
Synonyms: double-stranded hemi-methylated DNA binding
venom-mediated increase of sensory perception of pain (GO:0044742)
Namespace: biological_process
Definition: A process in which an organism initiates, promotes, or enhances sensory perception of pain in another organism via the action of a venom. Can manifest as allodynia, a condition that causes pain when a stimulus that normally wouldn't cause pain, or hyperalgesia, an increased sensitivity to feeling pain and an extreme response to pain.
Synonyms: allodynia; hyperalgesia
symbiont-mediated suppression of host synaptic transmission (GO:0044759)
Namespace: biological_process
Definition: A process in which a symbiont inhibits or disrupts the normal execution of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism.
Synonyms: negative regulation by symbiont of host synaptic transmission