LiteFold/GO huggingface dataset:
single-stranded DNA-binding protein complex (GO:0044777)
Namespace: cellular_component
Definition: A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair.
Synonyms: SSB complex
obsolete multi-organism membrane organization (GO:0044803)
Namespace: biological_process
Definition: OBSOLETE. A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism.
Comment: This term was obsoleted because there is no evidence that this process exists.
oncostatin M production (GO:0044808)
Namespace: biological_process
Definition: The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: OSM production
Nsk1-Dlc1 complex (GO:0044816)
Namespace: cellular_component
Definition: A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation.
mitotic G2/M transition checkpoint (GO:0044818)
Namespace: biological_process
Definition: A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.
host-mediated perturbation of viral RNA genome replication (GO:0044830)
Namespace: biological_process
Definition: A process in which a host organism alters or subverts viral RNA genome replication.
Synonyms: modulation by host of viral RNA genome replication; regulation by host of viral RNA genome replication
cell cycle G1/S phase transition (GO:0044843)
Namespace: biological_process
Definition: The cell cycle process by which a cell in G1 phase commits to S phase.
meiotic interphase II (GO:0044844)
Namespace: biological_process
Definition: The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge.
Comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
estrous cycle (GO:0044849)
Namespace: biological_process
Definition: A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
modulation by host of viral catalytic activity (GO:0044867)
Namespace: biological_process
Definition: The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected.
chitosome (GO:0045009)
Namespace: cellular_component
Definition: An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum.
mitochondrial degradosome (GO:0045025)
Namespace: cellular_component
Definition: A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.
Synonyms: mtEXO
T cell selection (GO:0045058)
Namespace: biological_process
Definition: The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms: T lymphocyte selection; T-cell selection; T-lymphocyte selection
negative thymic T cell selection (GO:0045060)
Namespace: biological_process
Definition: The process of elimination of immature T cells in the thymus which react strongly with self-antigens.
Synonyms: negative thymic T lymphocyte selection; negative thymic T-cell selection; negative thymic T-lymphocyte selection
positive extrathymic T cell selection (GO:0045067)
Namespace: biological_process
Definition: The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms: positive extrathymic T lymphocyte selection; positive extrathymic T-cell selection; positive extrathymic T-lymphocyte selection
obsolete peripherin (GO:0045102)
Namespace: cellular_component
Definition: OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system.
Synonyms: peripherin
Comment: This term was made obsolete because it represents a gene product.
intermediate filament depolymerization (GO:0045106)
Namespace: biological_process
Definition: Disassembly of intermediate filaments by the removal of component monomers from a filament.
development of secondary sexual characteristics (GO:0045136)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.
meiotic sister chromatid segregation (GO:0045144)
Namespace: biological_process
Definition: The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle.
Synonyms: meiosis II, chromosome segregation
single-stranded DNA 5'-3' DNA exonuclease activity (GO:0045145)
Namespace: molecular_function
Definition: Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.
Synonyms: single-stranded DNA specific 5'-3' exodeoxyribonuclease activity; ssDNA-specific 5'-3' exodeoxyribonuclease activity
tripeptide aminopeptidase activity (GO:0045148)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide.
Synonyms: alanine-phenylalanine-proline arylamidase activity; aminoexotripeptidase activity; aminotripeptidase activity; imidoendopeptidase activity; lymphopeptidase activity; peptidase B; peptidase T
obsolete secretin (sensu Mammalia) (GO:0045164)
Namespace: molecular_function
Definition: OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract.
Synonyms: secretin (sensu Mammalia)
Comment: This term was made obsolete because it represents a gene product rather than a molecular function.
basal protein localization (GO:0045175)
Namespace: biological_process
Definition: Any process in which a protein is transported to, or maintained in, basal regions of the cell.
Synonyms: basal protein localisation; establishment and maintenance of basal protein localization; establishment and maintenance of protein localization in basal part of cell
regulation of circadian sleep/wake cycle, non-REM sleep (GO:0045188)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.
Synonyms: regulation of non-REM sleep
maintenance of neuroblast polarity (GO:0045201)
Namespace: biological_process
Definition: The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
Synonyms: maintenance of neuroblast cell polarity
obsolete MAPK phosphatase transporter activity (GO:0045206)
Namespace: molecular_function
Definition: OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells.
Synonyms: leptomycin B-sensitive MAPK phosphatase transporter activity; leptomycin B-sensitive MKP shuttle; MAPK phosphatase transporter activity; MKP shuttle
Comment: This term was made obsolete because we do not know what it was intended to represent when it was created.
obsolete positive regulation of FasL production (GO:0045220)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.
Synonyms: activation of FasL biosynthetic process; positive regulation of FasL anabolism; positive regulation of FasL biosynthesis; positive regulation of FasL biosynthetic process; positive regulation of FasL formation; positive regulation of FasL synthesis; stimulation of FasL biosynthetic process; up regulation of FasL biosynthetic process; up-regulation of FasL biosynthetic process; upregulation of FasL biosynthetic process
Comment: The reason for obsoletion is that this term represents a gene product.
obsolete cytosolic isocitrate dehydrogenase complex (NAD+) (GO:0045243)
Namespace: cellular_component
Definition: OBSOLETE. Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity.
Synonyms: isocitrate dehydrogenase complex (NAD+)
Comment: The reason for obsoletion is that this term is unnecessarily taxon-specific.
obsolete plasma membrane respiratory chain complex II (GO:0045274)
Namespace: cellular_component
Definition: OBSOLETE. A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species.
Synonyms: respiratory chain complex II
Comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
luciferin monooxygenase activity (GO:0045289)
Namespace: molecular_function
Definition: Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation.
Synonyms: luciferase activity; luciferase monooxygenase activity
gamma-catenin binding (GO:0045295)
Namespace: molecular_function
Definition: Binding to catenin complex gamma subunit.
Synonyms: plakoglobin binding
regulation of establishment of competence for transformation (GO:0045304)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome.
Synonyms: regulator of establishment of competence for transformation activity
obsolete activator of the establishment of competence for transformation activity (GO:0045307)
Namespace: molecular_function
Definition: OBSOLETE. Activates the establishment of competence for transformation.
Synonyms: activator of the establishment of competence for transformation activity
Comment: This term was made obsolete because it does not represent a true function.
late endosome to vacuole transport (GO:0045324)
Namespace: biological_process
Definition: The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.
obsolete protein-DNA covalent cross-linking via peptidyl-tyrosine (GO:0045327)
Namespace: biological_process
Definition: OBSOLETE. The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue.
Synonyms: DNA-protein covalent cross-linking via peptidyl-tyrosine
Comment: The reason for obsoletion is that is not known to be catalyzed by any gene product.
male courtship behavior, veined wing generated song production (GO:0045433)
Namespace: biological_process
Definition: The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.
Synonyms: male courtship behavior, song production; male courtship behaviour, song production; male courtship behaviour, veined wing generated song production
endothelial cell differentiation (GO:0045446)
Namespace: biological_process
Definition: The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
trichothecene 3-O-acetyltransferase activity (GO:0045462)
Namespace: molecular_function
Definition: Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis.
R7 cell differentiation (GO:0045466)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor.
response to ether (GO:0045472)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.
obsolete response to ether (sensu Insecta) (GO:0045474)
Namespace: biological_process
Definition: OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus.
Synonyms: response to ether (sensu Insecta)
Comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
trichodiene synthase activity (GO:0045482)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene.
Synonyms: sesquiterpene cyclase activity; trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming); trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity; trichodiene synthetase activity
pole plasm (GO:0045495)
Namespace: cellular_component
Definition: Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.
Synonyms: germ plasm; polar plasm
interleukin-25 receptor activity (GO:0045507)
Namespace: molecular_function
Definition: Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: IL-25 receptor activity; IL-25R
interleukin-19 receptor binding (GO:0045516)
Namespace: molecular_function
Definition: Binding to an interleukin-19 receptor.
Synonyms: IL-19; interleukin-19 receptor ligand
interleukin-27 receptor binding (GO:0045523)
Namespace: molecular_function
Definition: Binding to an interleukin-27 receptor.
Synonyms: IL-27; interleukin-27 receptor ligand
gibberellin 20-oxidase activity (GO:0045544)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 2-oxoglutarate + gibberellin A12 (GA12) + H+ + 3 O2 = 3 CO2 + gibberellin A9 (GA9) + 2 H2O + 2 succinate. This reaction results in the oxidation of C-20 gibberellins to form the corresponding C-19 lactones, via a three-step oxidation at C-20 of the GA skeleton. Also converts GA53 to GA20. GA25 is also formed as a minor product.
9-cis-epoxycarotenoid dioxygenase activity (GO:0045549)
Namespace: molecular_function
Definition: Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al.
Synonyms: 9-cis-epoxycarotenoid 11,12-dioxygenase activity; AtNCED3; NCED; neoxanthin cleavage enzyme; nine-cis-epoxycarotenoid dioxygenase activity; PvNCED1; VP14
cinnamyl-alcohol dehydrogenase activity (GO:0045551)
Namespace: molecular_function
Definition: Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. Also acts on coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol.
Synonyms: CAD activity; cinnamyl alcohol dehydrogenase activity; cinnamyl-alcohol:NADP+ oxidoreductase activity
obsolete TRAIL receptor 1 biosynthetic process (GO:0045558)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway.
Synonyms: TRAIL receptor 1 anabolism; TRAIL receptor 1 biosynthesis; TRAIL receptor 1 formation; TRAIL receptor 1 synthesis; tumor necrosis factor receptor superfamily member 10A biosynthetic process
Comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
obsolete positive regulation of TRAIL receptor 1 biosynthetic process (GO:0045566)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1.
Synonyms: activation of TRAIL receptor 1 biosynthetic process; positive regulation of TRAIL receptor 1 anabolism; positive regulation of TRAIL receptor 1 biosynthesis; positive regulation of TRAIL receptor 1 formation; positive regulation of TRAIL receptor 1 synthesis; stimulation of TRAIL receptor 1 biosynthetic process; up regulation of TRAIL receptor 1 biosynthetic process; up-regulation of TRAIL receptor 1 biosynthetic process; upregulation of TRAIL receptor 1 biosynthetic process
Comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term.
mast cell activation (GO:0045576)
Namespace: biological_process
Definition: The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.
negative regulation of cytotoxic T cell differentiation (GO:0045584)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation.
Synonyms: down regulation of cytotoxic T cell differentiation; down-regulation of cytotoxic T cell differentiation; downregulation of cytotoxic T cell differentiation; inhibition of cytotoxic T cell differentiation; negative regulation of cytotoxic T cell development; negative regulation of cytotoxic T lymphocyte differentiation; negative regulation of cytotoxic T-cell differentiation; negative regulation of cytotoxic T-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
regulation of regulatory T cell differentiation (GO:0045589)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
Synonyms: regulation of regulatory T cell development; regulation of regulatory T lymphocyte differentiation; regulation of regulatory T-cell differentiation; regulation of regulatory T-lymphocyte differentiation; regulation of suppressor T cell differentiation; regulation of suppressor T lymphocyte differentiation; regulation of suppressor T-cell differentiation; regulation of suppressor T-lymphocyte differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
positive regulation of cell differentiation (GO:0045597)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cell differentiation.
Synonyms: activation of cell differentiation; stimulation of cell differentiation; up regulation of cell differentiation; up-regulation of cell differentiation; upregulation of cell differentiation
regulation of epidermal cell differentiation (GO:0045604)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of epidermal cell differentiation.
Synonyms: regulation of hypodermal cell differentiation
negative regulation of epidermal cell differentiation (GO:0045605)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.
Synonyms: down regulation of epidermal cell differentiation; down-regulation of epidermal cell differentiation; downregulation of epidermal cell differentiation; inhibition of epidermal cell differentiation; negative regulation of hypodermal cell differentiation
regulation of hemocyte differentiation (GO:0045610)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of hemocyte differentiation.
Synonyms: regulation of arthropod blood cell differentiation
regulation of lymphocyte differentiation (GO:0045619)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of lymphocyte differentiation.
Synonyms: regulation of lymphocyte development
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
negative regulation of lymphocyte differentiation (GO:0045620)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.
Synonyms: down regulation of lymphocyte differentiation; down-regulation of lymphocyte differentiation; downregulation of lymphocyte differentiation; inhibition of lymphocyte differentiation; negative regulation of lymphocyte development
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
positive regulation of T-helper cell differentiation (GO:0045624)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.
Synonyms: activation of T-helper cell differentiation; positive regulation of T-helper cell development; stimulation of T-helper cell differentiation; up regulation of T-helper cell differentiation; up-regulation of T-helper cell differentiation; upregulation of T-helper cell differentiation
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
regulation of monocyte differentiation (GO:0045655)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of monocyte differentiation.
regulation of neutrophil differentiation (GO:0045658)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of neutrophil differentiation.