LiteFold/GO huggingface dataset:
cholecystokinin receptor activity (GO:0004951)
Namespace: molecular_function
Definition: Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone.
Synonyms: CCK receptor activity
beta-endorphin receptor activity (GO:0004979)
Namespace: molecular_function
Definition: Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC).
Synonyms: mu-opioid receptor activity
obsolete mu-opioid receptor activity (GO:0004988)
Namespace: molecular_function
Definition: OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins.
Synonyms: mu-opioid receptor activity
Comment: This term was made obsolete because the receptor is defined based on its pharmacological properties.
oxytocin receptor activity (GO:0004990)
Namespace: molecular_function
Definition: Combining with oxytocin to initiate a change in cell activity.
thyroid-stimulating hormone receptor activity (GO:0004996)
Namespace: molecular_function
Definition: Combining with thyroid-stimulating hormone to initiate a change in cell activity.
Synonyms: thyroid stimulating hormone receptor activity; thyrotropin receptor; TSH receptor activity
platelet-derived growth factor alpha-receptor activity (GO:0005018)
Namespace: molecular_function
Definition: Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.
Synonyms: alphaPDGF receptor activity; PDGF alpha-receptor activity
transforming growth factor beta receptor activity, type II (GO:0005026)
Namespace: molecular_function
Definition: Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor.
Synonyms: transforming growth factor beta ligand binding to type II receptor; type II TGF-beta receptor activity; type II TGFbeta receptor activity; type II transforming growth factor beta receptor activity
obsolete CD40 receptor activity (GO:0005028)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: CD40 receptor activity
Comment: This term was made obsolete because it describes the receptor type, and not an activity.
obsolete death receptor-associated factor activity (GO:0005039)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: death receptor-associated factor activity
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
signal sequence binding (GO:0005048)
Namespace: molecular_function
Definition: Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.
Synonyms: leader sequence binding; protein signal sequence binding; signal sequence receptor
obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity (GO:0005071)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: transmembrane receptor protein serine/threonine kinase signaling protein activity; transmembrane receptor protein serine/threonine kinase signalling protein activity
Comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
obsolete pathway-specific SMAD protein (GO:0005075)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: pathway-specific SMAD protein
Comment: This term was made obsolete because it represents a family of gene products.
obsolete MAP-kinase anchoring activity (GO:0005077)
Namespace: molecular_function
Definition: OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location.
Synonyms: MAP-kinase anchor protein activity; MAP-kinase anchoring activity
Comment: This term was made obsolete because it represents a combination of process and function information.
MAP kinase scaffold activity (GO:0005078)
Namespace: molecular_function
Definition: The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
Synonyms: MAP-kinase scaffold protein activity
fibroblast growth factor receptor binding (GO:0005104)
Namespace: molecular_function
Definition: Binding to a fibroblast growth factor receptor (FGFR).
Synonyms: FGF receptor binding; FGFR binding; FGFR ligand; fibroblast growth factor; fibroblast growth factor receptor ligand
Comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor.
obsolete transmembrane ephrin (GO:0005108)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: transmembrane ephrin
Comment: This term was made obsolete because it refers to a class of gene products.
scavenger receptor binding (GO:0005124)
Namespace: molecular_function
Definition: Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.
Synonyms: scavenger receptor ligand
cytokine activity (GO:0005125)
Namespace: molecular_function
Definition: The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
Synonyms: autocrine activity; paracrine activity; phytocytokine activity
interleukin-2 receptor binding (GO:0005134)
Namespace: molecular_function
Definition: Binding to an interleukin-2 receptor.
Synonyms: IL-2; interleukin-2 receptor ligand
interleukin-6 receptor binding (GO:0005138)
Namespace: molecular_function
Definition: Binding to an interleukin-6 receptor.
Synonyms: IL-6; interleukin-6 receptor ligand
interleukin-9 receptor binding (GO:0005140)
Namespace: molecular_function
Definition: Binding to an interleukin-9 receptor.
Synonyms: IL-9; interleukin-9 receptor ligand
interleukin-12 receptor binding (GO:0005143)
Namespace: molecular_function
Definition: Binding to an interleukin-12 receptor.
Synonyms: IL-12; interleukin-12 receptor ligand
integrin binding (GO:0005178)
Namespace: molecular_function
Definition: Binding to an integrin.
Synonyms: integrin ligand
obsolete glycopeptide hormone (GO:0005181)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: glycopeptide hormone
Comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
neurohypophyseal hormone activity (GO:0005185)
Namespace: molecular_function
Definition: The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin.
Synonyms: neurohypophysial hormone activity
pheromone activity (GO:0005186)
Namespace: molecular_function
Definition: The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant.
Comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.
obsolete acidic epididymal glycoprotein (GO:0005191)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: acidic epididymal glycoprotein
Comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
structural molecule activity (GO:0005198)
Namespace: molecular_function
Definition: The action of a molecule that contributes to the structural integrity of a complex.
calcium channel regulator activity (GO:0005246)
Namespace: molecular_function
Definition: Modulates the activity of a calcium channel.
chloride channel activity (GO:0005254)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.
monoatomic cation channel activity (GO:0005261)
Namespace: molecular_function
Definition: Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel.
Synonyms: cation channel activity; cation diffusion facilitator activity; non-selective cation channel activity
L-histidine transmembrane transporter activity (GO:0005290)
Namespace: molecular_function
Definition: Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
Synonyms: histidine/arginine/lysine/ornithine porter activity; L-histidine transporter activity
high-affinity L-glutamate transmembrane transporter activity (GO:0005314)
Namespace: molecular_function
Definition: Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high-affinity glutamate transmembrane transporter activity; high-affinity glutamate transporter activity
nucleotide-sulfate transmembrane transporter activity (GO:0005340)
Namespace: molecular_function
Definition: Enables the transfer of nucleotide-sulfate from one side of a membrane to the other.
Synonyms: nucleotide-sulphate transporter activity
ATP transmembrane transporter activity (GO:0005347)
Namespace: molecular_function
Definition: Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other.
carbohydrate:proton symporter activity (GO:0005351)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
Synonyms: cation/sugar symporter activity; hydrogen:sugar symporter activity; hydrogen:sugar transporter activity; lactose/glucose efflux transporter activity; proton:sugar symporter activity; sugar efflux transmembrane transporter activity; sugar porter activity; sugar transporter; sugar:hydrogen ion symporter activity; sugar:hydrogen symporter activity; sugar:proton symporter activity
maltose transmembrane transporter activity (GO:0005363)
Namespace: molecular_function
Definition: Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch.
Synonyms: maltose porter activity
water transmembrane transporter activity (GO:0005372)
Namespace: molecular_function
Definition: Enables the transfer of water (H2O) from one side of a membrane to the other.
obsolete synaptic vesicle amine transmembrane transporter activity (GO:0005430)
Namespace: molecular_function
Definition: OBSOLETE. Enables the transfer of amines across synaptic vesicle membranes.
Comment: The class was obsoleted because the cellular location of a function should not be part of the class label.
calcium:sodium antiporter activity (GO:0005432)
Namespace: molecular_function
Definition: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
Synonyms: mitochondrial sodium/calcium ion exchange; sodium/calcium exchanger; sodium:calcium exchange
pyruvate secondary active transmembrane transporter activity (GO:0005477)
Namespace: molecular_function
Definition: Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
Synonyms: pyruvate carrier activity
obsolete vesicle transport (GO:0005480)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: vesicle transport
Comment: This term was made obsolete because it represents a biological process and not a molecular function.
iron ion binding (GO:0005506)
Namespace: molecular_function
Definition: Binding to an iron (Fe) ion.
Synonyms: iron binding
insulin-like growth factor binding (GO:0005520)
Namespace: molecular_function
Definition: Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
Synonyms: IGF binding
ATP binding (GO:0005524)
Namespace: molecular_function
Definition: Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Synonyms: Mg-ATP binding; MgATP binding
GTP binding (GO:0005525)
Namespace: molecular_function
Definition: Binding to GTP, guanosine triphosphate.
1-phosphatidylinositol binding (GO:0005545)
Namespace: molecular_function
Definition: Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
odorant binding (GO:0005549)
Namespace: molecular_function
Definition: Binding to an odorant, any substance capable of stimulating the sense of smell.
obsolete polyubiquitin (GO:0005552)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: polyubiquitin
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
obsolete membrane attack complex protein alphaM chain (GO:0005580)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: membrane attack complex protein alphaM chain
Comment: This term was made obsolete because it represents a single gene product and not a complex.
collagen type I trimer (GO:0005584)
Namespace: cellular_component
Definition: A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.
collagen type XIII trimer (GO:0005600)
Namespace: cellular_component
Definition: A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane.
laminin-332 trimer (GO:0005610)
Namespace: cellular_component
Definition: A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains.
Synonyms: laminin-332 complex; laminin-3A32 complex; laminin-5 complex; laminin-5A complex
obsolete larval serum protein-1 (GO:0005617)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: larval serum protein-1; LSP1
Comment: This term was made obsolete because it represents a gene product.
prospore membrane (GO:0005628)
Namespace: cellular_component
Definition: The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe.
Synonyms: ascospore-type prospore membrane; forespore membrane; FSM
obsolete RAN-binding protein (GO:0005645)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: RAN-binding protein
Comment: This term was made obsolete because it represents a single gene product and not a complex.
RNA polymerase transcription factor SL1 complex (GO:0005668)
Namespace: cellular_component
Definition: A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.
Synonyms: selectivity factor SL1 complex; TIF-IB
transcription factor TFIID complex (GO:0005669)
Namespace: cellular_component
Definition: A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
obsolete telomere (GO:0005696)
Namespace: cellular_component
Definition: OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA.
Synonyms: telomere
Comment: This term was made obsolete because the definition was too sequence oriented and too restrictive.
polytene chromosome band (GO:0005704)
Namespace: cellular_component
Definition: A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band.
polytene chromosome ectopic fiber (GO:0005706)
Namespace: cellular_component
Definition: A thread-like connection joining two regions of ectopically paired polytene chromosomes.
Synonyms: polytene chromosome ectopic fibre
pericentric heterochromatin (GO:0005721)
Namespace: cellular_component
Definition: Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).
Synonyms: centric heterochromatin; centromeric heterochromatin; chromosome, centric outer repeat region; chromosome, centromeric inner repeat region; chromosome, centromeric outer repeat region; nuclear centric heterochromatin; nuclear cluster; nuclear pericentric heterochromatin
2-micrometer circle DNA (GO:0005729)
Namespace: cellular_component
Definition: A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies.
obsolete box C + D snoRNP protein (GO:0005734)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: box C + D snoRNP protein
Comment: This term was made obsolete because it represents a gene product.
cytoplasm (GO:0005737)
Namespace: cellular_component
Definition: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
m-AAA complex (GO:0005745)
Namespace: cellular_component
Definition: Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria.
obsolete mitochondrial respiratory chain complex IV (GO:0005751)
Namespace: cellular_component
Definition: OBSOLETE. A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
Comment: The reason for obsoletion is that this term unnecssarily specified a cellular compartment.
gamma DNA polymerase complex (GO:0005760)
Namespace: cellular_component
Definition: A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.
smooth endoplasmic reticulum (GO:0005790)
Namespace: cellular_component
Definition: The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
Synonyms: SER; smooth ER
Golgi-associated vesicle (GO:0005798)
Namespace: cellular_component
Definition: Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.
Synonyms: Golgi vesicle; vesicular component
Comment: Note that this definition includes vesicles that are transiently associated with the Golgi.
obsolete coatomer (GO:0005799)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: coatomer; COPI vesicle
Comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself.
obsolete centrosomal mitotic factor (GO:0005817)
Namespace: cellular_component
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: centrosomal mitotic factor
Comment: This term was made obsolete because it was not defined.
aster (GO:0005818)
Namespace: cellular_component
Definition: An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores.
outer plaque of spindle pole body (GO:0005824)
Namespace: cellular_component
Definition: One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm.
nuclear cap binding complex (GO:0005846)
Namespace: cellular_component
Definition: A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
Synonyms: CBC; mRNA cap binding complex; NCBP-NIP1 complex; nuclear CBC; snRNA cap binding complex
Comment: Note that this complex can be found in the cytoplasm as well as the nucleus.
mRNA cleavage factor complex (GO:0005849)
Namespace: cellular_component
Definition: Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.
eukaryotic translation initiation factor 2B complex (GO:0005851)
Namespace: cellular_component
Definition: A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
Synonyms: eIF-2B; eif2B