LiteFold/GO huggingface dataset:
positive regulation of oxytocin production (GO:0140668)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of production of oxytocin.
negative regulation of oxytocin production (GO:0140669)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the rate of production of oxytocin.
molecular condensate scaffold activity (GO:0140693)
Namespace: molecular_function
Definition: Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate.
Synonyms: phase separation nucleation activity; phase separation nucleator activity
attachment of telomeric heterochromatin to nuclear envelope (GO:0140698)
Namespace: biological_process
Definition: The process in which physical connections are formed between sub-telomeric heterochromatin and the nuclear envelope facilitating bouquet formation.
Synonyms: attachment of telomeres to nuclear envelope; attachment of telomeric chromatin to nuclear envelope; heterochromatin organization
chromatin-nuclear membrane anchor activity (GO:0140707)
Namespace: molecular_function
Definition: Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis.
NLRP6 inflammasome complex assembly (GO:0140739)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex.
tRNA-uracil-4 sulfurtransferase activity (GO:0140741)
Namespace: molecular_function
Definition: Catalyzes the reaction: ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster = AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster.
Synonyms: tRNA U4 sulfurtransferase; tRNA uracil 4 sulfurtransferase; tRNA uracil 4-sulfurtransferase
positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process (GO:0140748)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process.
NAD-dependent protein depalmitoylase activity (GO:0140774)
Namespace: molecular_function
Definition: Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
protein-containing complex destabilizing activity (GO:0140776)
Namespace: molecular_function
Definition: A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex.
Synonyms: protein unfoldase activity
novofumigatonin biosynthetic process (GO:0140782)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety.
Synonyms: novofumigatonin anabolism; novofumigatonin biosynthesis; novofumigatonin formation; novofumigatonin synthesis
histone H3R26 arginine deiminase activity (GO:0140798)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone H3 L-arginyl (position 26)= histone H3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26.
Synonyms: H3-R26 citrullination; histone H3-R26 arginine deiminase activity; histone-arginine deiminase activity (H3-R26 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism. The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
histone H4R3 arginine deiminase activity (GO:0140809)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3.
Synonyms: H4-R3 citrullination; histone H4-R3 arginine deiminase activity; histone-arginine deiminase activity (H4-R3 specific)
Comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1. The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
histone H2AR3 arginine deiminase activity (GO:0140811)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3.
Synonyms: H2A-R3 citrullination; histone H2A-R3 arginine deiminase activity; histone-arginine deiminase activity (H2A-R3 specific)
Comment: Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue seems to be only present in animals. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism. The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635).
ATP-dependent H2AZ histone chaperone activity (GO:0140849)
Namespace: molecular_function
Definition: A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.
Synonyms: ATP-dependent H2A.Z histone chaperone activity; H2AZ histone exchange activity
Comment: Drosophila H2AV corresponds to histone H2AZ.
pterocarpan synthase activity (GO:0140859)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol.
Synonyms: 2',7-dihydroxy-4'-methoxyisoflavanol dehydratase activity; 2'-hydroxyisoflavanol 4,2'-dehydratase activity; 7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase activity; medicarpan synthase activity; medicarpin synthase activity
interleukin-20-mediated signaling pathway (GO:0140866)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-20 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-20-mediated signaling pathway; interleukin-20-mediated signalling pathway
viridicatumtoxin biosynthetic process (GO:0140872)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system.
Synonyms: viridicatumtoxin anabolism; viridicatumtoxin biosynthesis; viridicatumtoxin formation; viridicatumtoxin synthesis
PR-toxin biosynthetic process (GO:0140875)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin.
Synonyms: PR-toxin anabolism; PR-toxin biosynthesis; PR-toxin formation; PR-toxin synthesis
positive regulation terrein biosynthetic process (GO:0140881)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of the fungal metabolite terrein.
DNA replication-dependent chromatin disassembly (GO:0140889)
Namespace: biological_process
Definition: The disruption of nucleosomes during DNA replication to allow the replication machinery to access the DNA.
histone H3K122 acetyltransferase activity (GO:0140908)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122).
Synonyms: histone acetylase activity (H3-K122 specific); histone acetyltransferase activity (H3-K122 specific); histone H3-K122 acetyltransferase activity; histone lysine N-acetyltransferase activity (H3-K122 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
magnetosome assembly (GO:0140923)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a magnetosome. Magnetosomes are specialized organelles for magnetic navigation that comprise membrane-enveloped, nano-sized crystals of a magnetic iron mineral; they are formed by a diverse group of magnetotactic bacteria (MTB).
Synonyms: magnetosome formation
histone H3K9 monomethyltransferase activity (GO:0140948)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me.
Synonyms: histone H3-K9 methylation; histone H3K9 methylation; histone H3K9 monomethylase activity; histone lysine N-monomethyltransferase activity (H3-K9 specific)
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
cellular detoxification of sulfide (GO:0140974)
Namespace: biological_process
Definition: Any process carried out at the cellular level that reduces or removes the toxicity of a sulfide. These may include chemical modification or transport of sulfide away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
ADP:phosphate antiporter activity (GO:0140988)
Namespace: molecular_function
Definition: Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + phosphate(in) = ADP(in) + phosphate(out).
Synonyms: ADP:inorganic phosphate antiporter activity; inorganic phosphate:ADP antiporter activity
transposable element silencing by heterochromatin formation (GO:0141005)
Namespace: biological_process
Definition: A transposable element silencing mechanism involving heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
Synonyms: retrotransposon silencing by heterochromatin formation
purine nucleotide import into lysosome (GO:0141013)
Namespace: biological_process
Definition: The directed import of purine nucleotide from the cytosol, across the lysosomal membrane, into the lysosome.
symbiont-mediated disruption of host focal adhesion (GO:0141029)
Namespace: biological_process
Definition: A process in which a symbiont alters or subverts focal adhesion in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption by symbiont of host focal adhesion
histone H2B ubiquitin ligase activity (GO:0141054)
Namespace: molecular_function
Definition: Catalysis of the transfer of ubiquitin to a histone H2B substrate.
histone H4 ubiquitin ligase activity (GO:0141056)
Namespace: molecular_function
Definition: Catalysis of the transfer of ubiquitin to a histone H4 substrate.
disruption of anatomical structure in another organism (GO:0141060)
Namespace: biological_process
Definition: The disruption of an anatomical structure of another organism, leading to damage or temporary subversion of that structure.
obsolete disruption of tissue in another organism (GO:0141062)
Namespace: biological_process
Definition: OBSOLETE. The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue.
Synonyms: tissue necrosis in another organism
Comment: This term was obsoleted because it is an unnecessary grouping class.
symbiont-mediated suppression of host cGAS-STING signal transduction (GO:0141074)
Namespace: biological_process
Definition: A process in which a virus interferes with, inhibits or disrupt a cGAS/STING signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: disruption of host cGAS-STING signal transduction; disruption of host cGAS-STING signaling; suppression of host cGAS-STING
positive regulation of nodal signaling pathway (GO:0141092)
Namespace: biological_process
Definition: Any process that increases the rate, frequency or extent of nodal signaling pathway.
tRNA (guanine(18)-2'-O-ribose)-methyltransferase activity (GO:0141100)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 18 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 18 in tRNA + H+.
Synonyms: tRNA (guanine(18)-2'-O-)-methyltransferase activity; tRNA (guanosine(18)-2'-O)-methyltransferase activity
tRNA(Ser) (uridine(44)-2'-O-ribose)-methyltransferase activity (GO:0141101)
Namespace: molecular_function
Definition: Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + uridine44 in tRNASer = 2'-O-methyluridine44 in tRNASer + H+ + S-adenosyl-L-homocysteine.
Synonyms: tRNA(Ser) (uracil(44)-2'-O-)-methyltransferase activity; tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity
transporter inhibitor activity (GO:0141110)
Namespace: molecular_function
Definition: Binds to and stops, prevents, or reduces the activity of a transporter.
nitric oxide dioxygenase activity, heme protein as donor (GO:0141118)
Namespace: molecular_function
Definition: Catalysis of the reaction: Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate.
Comment: Note that this activity is similar to nitric oxide dioxygenase activity ; GO:0008941, but GO:000894 uses NADPH as the electron donor.
chromosomal DNA methylation maintenance following DNA replication (GO:0141119)
Namespace: biological_process
Definition: The process that maintains methylated cytosine in newly synthesized DNA following DNA replication. After the establishment of novel DNA methylation marks, the newly created patterns must be faithfully transmitted by maintenance DNA methyltransferases during cell division.
Synonyms: DNA methylation; DNA methylation maintenance; DNA methylation maintenance following cell division; DNA methylation maintenance following DNA replication; genome methylation maintenance following DNA replication
Comment: CG methylation is maintained by two evolutionarily conserved core partners: (1) a maintenance DNA methyltransferase called DNMT1 in mammals and MET1 (DNA METHYLTRANSFERASE 1) in plants and (2) a cofactor named UHRF1 in mammals and VIM (VARIANT IN METHYLATION) in plants. In mammals, the maintenance of non-CG methylation typically involves DNMT3 enzymes. In plants, non-CG methylation is further divided in two classes of sequence, CHG and CHH, and requires distinct enzymatic machineries.
venom-mediated dermonecrosis in another organism (GO:0141123)
Namespace: biological_process
Definition: The disruption of the skin of another organism, leading to damage or temporary subversion of the skin.
mitochondrial protein quality control (GO:0141164)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the mitochondrion, which are targeted for degradation.
chromosomal 5-methylcytosine DNA demethylation pathway (GO:0141166)
Namespace: biological_process
Definition: A process that chemically modifies 5-methylcytosine (5meC) to make it a substrate for the base excision repair pathway, which then restores the unmodified cytosine.
Synonyms: epigenetic 5-methylcytosine DNA demethylation; epigenetic 5-methylcytosine DNA demethylation pathway; epigenetic DNA demethylation
Comment: Note that this term describes the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child.
chromosomal 5-methylcytosine DNA demethylation, oxidative deamination pathway (GO:0141168)
Namespace: biological_process
Definition: An epigenetic cytosine DNA demethylation pathway that includes a deamination step to produce either a thymine (T), or a 5-hydroxymethyluracil (5hmU), if the 5meC had first been converted to 5hmC. A DNA glycosylase (e. g. TDG) recognizes the T mispaired with a G or the 5hmC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair.
Synonyms: epigenetic 5-methylcytosine DNA demethylation, oxidative deamination pathway; epigenetic DNA demethylation, oxidative deamination pathway
Comment: Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child. A similar pathway may also convert chromosomal DNA N6-methyladenosine to adenosine but little evidence exists for this pathway. Current evidence indicates that this pathway in used for DNA repair, and not for epigenetic gene expression regulation.
dsDNA-RNA triple helix-forming chromatin adaptor activity (GO:0141180)
Namespace: molecular_function
Definition: A chromatin-protein adaptor activity that bridges dsDNA and chromatin proteins to bring regions of a chromosome in proximity. The DNA:DNA:RNA triple-helical structure is formed non-Watson-Crick base-pairing.
ATP:ATP adenylyltransferase activity (GO:0141192)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 ATP + H+ = diphosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
Synonyms: adenine triphosphate adenylyltransferase activity
phospholipase C/protein kinase C signal transduction (GO:0141212)
Namespace: biological_process
Definition: An intracellular signaling cassette that starts with activation of phospholipase C (PLC) activity and ends with the activation of protein kinase C (PKC). PLC produces inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. This cassette is often part of the phospholipase C-activating G protein-coupled receptor signaling pathway.
Synonyms: PLC/PKC signaling; PLC/PKC/PKD signaling
NAD-dependent protein lysine deacylase activity (GO:0141218)
Namespace: molecular_function
Definition: Catalysis of the reaction: N6-acyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-acyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein].
Synonyms: protein lysine deacylase activity
histone H3K4 deacetylase activity, NAD-dependent (GO:0141222)
Namespace: molecular_function
Definition: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K4 to NAD, producing nicotinamide.
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
clathrin-dependent synaptic vesicle endocytosis (GO:0150007)
Namespace: biological_process
Definition: Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.
apical proximal dendrite (GO:0150015)
Namespace: cellular_component
Definition: The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma).
postsynaptic septin cytoskeleton (GO:0150050)
Namespace: cellular_component
Definition: The portion of the septin cytoskeleton contained within the postsynapse.
vertebrate eye-specific patterning (GO:0150064)
Namespace: biological_process
Definition: Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus.
Synonyms: binocular vision development; eye-specific patterning; eye-specific segregation; vertebrate eye-specific segregation
obsolete positive regulation of arginase activity (GO:0150072)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of arginase activity.
Comment: This term was obsoleted because it represents a molecular function.
obsolete regulation of protein-glutamine gamma-glutamyltransferase activity (GO:0150073)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.
Comment: This term was obsoleted because it represents a molecular function.
amyloid-beta clearance by cellular catabolic process (GO:0150094)
Namespace: biological_process
Definition: The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
Synonyms: amyloid-beta clearance by phagocytosis
positive regulation of cell-substrate junction organization (GO:0150117)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization.
negative regulation of cell-substrate junction organization (GO:0150118)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization.
regulation of interleukin-37 production (GO:0150136)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of interleukin-37 production.
Synonyms: regulation of interleukin-37 biosynthetic process
interleukin-37 production (GO:0150137)
Namespace: biological_process
Definition: The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
Synonyms: interleukin-37 biosynthetic process
interleukin-34 production (GO:0150155)
Namespace: biological_process
Definition: The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
obsolete positive regulation of histone H3-K4 acetylation (GO:0150167)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H3-K4 acetylation.
Comment: This term was obsoleted because it represents a molecular function.