LiteFold/GO huggingface dataset:
obsolete positive regulation of phosphatidylcholine metabolic process (GO:0150173)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylcholine metabolic process.
Comment: This term was obsoleted because it is an unnecessary grouping class.
poly-ADP-D-ribose modification-dependent protein binding (GO:0160004)
Namespace: molecular_function
Definition: Binding to a protein upon poly-ADP-ribosylation of the target protein.
Comment: This term should only be used when the binding is shown to require a poly-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
craniofacial suture closure (GO:0160048)
Namespace: biological_process
Definition: The process of fusing together the edges of a craniofacial suture.
macropinosome membrane (GO:0160056)
Namespace: cellular_component
Definition: The lipid bilayer surrounding a macropinosome.
multi-pass translocon complex (GO:0160064)
Namespace: cellular_component
Definition: A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47).
Synonyms: MPT complex; TMCO1 translocon
non-canonical inflammasome complex (GO:0160074)
Namespace: cellular_component
Definition: An inflammasome complex containing CASP4, known as caspase-11 (Casp11) in mouse, which assembles upon cytosolic lipopolysaccharide-binding and directly activates Gasdermin-D (GSDMD).
G protein-coupled glycine receptor activity (GO:0160079)
Namespace: molecular_function
Definition: Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signaling.
Synonyms: metabotropic glycine receptor activity; mGlyR
protein localization to polar microtubule (GO:0160086)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a location within a polar microtubule.
animal gross anatomical part developmental process (GO:0160108)
Namespace: biological_process
Definition: Any developmental process whose specific outcome is the progression of a gross anatomical part of an animal from an initial immature state, to a later, more mature state.
Synonyms: animal development
axonemal B tubule inner sheath (GO:0160112)
Namespace: cellular_component
Definition: A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule.
tRNA (guanine(6)-N2)-methyltransferase activity (GO:0160117)
Namespace: molecular_function
Definition: Catalysis of the reaction: guanosine(6) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine.
Synonyms: m(2)G6 methyltransferase; methyltransferase Trm14
mRNA cap methyltransferase RNMT:RAMAC complex (GO:0160130)
Namespace: cellular_component
Definition: A protein complex that consists of RNA guanine-7 methyltransferase (RNMT) and RNA guanine-7 methyltransferase activating subunit (RAMAC) and is involved in mRNA cap methylation.
23S rRNA pseudouridine(2605) synthase activity (GO:0160139)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA.
mitochondrial tRNA pseudouridine(27/28) synthase activity (GO:0160153)
Namespace: molecular_function
Definition: Catalysis of the reaction: uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA.
fibrous body-membranous organelle (GO:0160208)
Namespace: cellular_component
Definition: A Golgi-derived organelle that forms in primary spermatocytes during spermatogenesis of some nematodes including C. elegans. This 'double organelle' consists of a fibrous body containing major sperm protein and a membranous organelle that envelops the developing fibrous body.
Synonyms: FB-MO
deacylase activity (GO:0160215)
Namespace: molecular_function
Definition: Catalysis of the reaction: R-CO-X + H2O = R-COOH + HX, hydrolysis of an acyl group or groups from a substrate molecule.
negative regulation of pyruvate decarboxylation to acetyl-CoA (GO:0160218)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions.
Synonyms: negative regulation of acetyl-CoA biosynthetic process from pyruvate
cortical endoplasmic reticulum membrane (GO:0160219)
Namespace: cellular_component
Definition: The lipid bilayer surrounding the cortical endoplasmic reticulum.
RNA polymerase II transcription initiation surveillance (GO:0160240)
Namespace: biological_process
Definition: A process that promotes premature RNA polymerase II transcription termination of transcripts that are unfavorably configured for transcriptional elongation by releasing RNA polymerase II from bound DNA or promoting RNA polymerase II degradation.
sulfite export across plasma membrane (GO:0160244)
Namespace: biological_process
Definition: The directed movement of sulfite from inside of a cell, across the plasma membrane and into the extracellular region.
Synonyms: sulfite efflux
tRNA queuosine(34) biosynthetic process from salvaged queuine (GO:0160255)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of tRNA queuosine(34) by salvaging available queuine.
endoplasmic reticulum-trans-Golgi network membrane contact site (GO:0160258)
Namespace: cellular_component
Definition: An organelle membrane contact site between the endoplasmic reticulum (ER) membrane and the trans-Golgi network (TGN) membrane.
lumenal side of cis-Golgi cisternae membrane (GO:0160277)
Namespace: cellular_component
Definition: The leaflet of the cis-Golgi cisternae membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where glycosylation and lumen-facing cargo recognition occur.
Synonyms: lumenal face of cis-Golgi cisternae membrane; lumenal leaflet of cis-Golgi cisternae membrane
sodium-translocating NADH-quinone reductase complex assembly (GO:0160293)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a sodium-translocating NADH-quinone reductase complex.
Synonyms: Na(+)-NQR complex assembly; Na(+)-translocating NADH-quinone reductase complex assembly
cap-dependent translation initiation factor activity (GO:0160296)
Namespace: molecular_function
Definition: A translation initiation factor activity that enables the recognition and binding to the 7-methylguanosine cap structure at the 5' end of eukaryotic mRNAs, promoting ribosome recruitment and assembly and translation initiation in a cap-dependent manner.
iron-guanylylpyridinol cofactor biosynthetic process (GO:0160300)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of iron-guanylylpyridinol cofactor, in which mononuclear Fe(II) is ligated with a pyridinol and two CO ligands.
Synonyms: Fe-GP cofactor biosynthetic process
octopamine loading into synaptic vesicle (GO:0160312)
Namespace: biological_process
Definition: The active transport of octopamine neurotransmitters into a synaptic vesicle.
ergothioneine transmembrane transporter activity (GO:0170001)
Namespace: molecular_function
Definition: Enables the transfer of ergothioneine from one side of a membrane to the other.
heme B transmembrane transporter activity (GO:0170003)
Namespace: molecular_function
Definition: Enables the transfer of heme B from one side of a membrane to the other.
export from the mitochondrion (GO:0170037)
Namespace: biological_process
Definition: The directed movement of substances from the mitochondrion to the cytosol.
isopentenyl pyrophosphate transmembrane transporter activity (GO:0170045)
Namespace: molecular_function
Definition: Enables the transfer of isopentenyl pyrophosphate from one side of a membrane to the other.
Synonyms: IPP transmembrane transport activity; isopentenyl diphosphate transmembrane transport activity
nickel chaperone activity (GO:0170061)
Namespace: molecular_function
Definition: Directly binding to and delivering nickel ions to a target protein.
Synonyms: nickel carrier activity
geranylgeranyltransferase type III activity (GO:0170068)
Namespace: molecular_function
Definition: Catalyzes the covalent addition of a geranylgeranyl group to a mono-farnesylated substrate via a thioether linkage to a cysteine residue located within a conserved C-terminal tandem cysteine motif (CCAIM or CCIIM) that is used in substrate recognition. Known substrates include mono-farnesylated Golgi SNARE proteins.
Synonyms: Geranylgeranyl transferase type-3 activity; geranylgeranyltransferase type 3 activity; GGTase-3 activity; GGTase-III activity; GGTase3 activity
cytosolic mRNA polyadenylation (GO:0180011)
Namespace: biological_process
Definition: Any process by which dormant, translationally inactive mRNAs become activated, or mRNAs become stabilized, via the elongation of their poly(A) tails in the cytosol.
K11-linked deubiquitinase activity (GO:0180017)
Namespace: molecular_function
Definition: Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin.
inner nuclear membrane-associated protein degradation pathway (GO:0180027)
Namespace: biological_process
Definition: A protein quality control pathway that removes ubiquitinated proteins from the nuclear inner membrane before transferring them to the proteasome for degradation.
Synonyms: INMAD pathway
response to metal ion starvation (GO:0180055)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of some metal ion.
protein O-linked glycosylation via galactose (GO:0180062)
Namespace: biological_process
Definition: A glycoprotein biosynthetic process starting with the covalent linkage of galactose via a beta-glycosidic bond to the oxygen atom of the hydroxyl group of a hydroxyproline, a hydroxylysine, a serine or a threonine in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan. Hydroxylysine modification occurs in the endoplasmic reticulum and is predominantly found in collagen. Hydroxyproline modification occurs in the Golgi and is found only in plant proteins.
Synonyms: protein O-linked galactosylation
mitochondrial small ribosomal subunit binding (GO:0180065)
Namespace: molecular_function
Definition: Binding to a mitochondrial small ribosomal subunit.
Synonyms: mtSSU binding
obsolete cell-cell signaling by wnt (GO:0198738)
Namespace: biological_process
Definition: OBSOLETE. Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the receiving cell.
Comment: The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.
positive regulation of ruffle assembly (GO:1900029)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of ruffle assembly.
Synonyms: positive regulation of membrane ruffle formation; positive regulation of membrane ruffling; up regulation of membrane ruffle formation; up regulation of membrane ruffling; up regulation of ruffle assembly
positive regulation of cellular response to heat (GO:1900036)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of cellular response to heat.
Synonyms: activation of cellular response to heat; activation of cellular response to heat stress; positive regulation of cellular response to heat stress; up regulation of cellular response to heat; up regulation of cellular response to heat stress; up-regulation of cellular response to heat; up-regulation of cellular response to heat stress; upregulation of cellular response to heat; upregulation of cellular response to heat stress
negative regulation of leaf senescence (GO:1900056)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence.
Synonyms: down regulation of leaf senescence; down-regulation of leaf senescence; downregulation of leaf senescence; inhibition of leaf senescence
negative regulation of ceramide biosynthetic process (GO:1900060)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.
Synonyms: down regulation of ceramide anabolism; down regulation of ceramide biosynthesis; down regulation of ceramide biosynthetic process; down regulation of ceramide formation; down regulation of ceramide synthesis; down-regulation of ceramide anabolism; down-regulation of ceramide biosynthesis; down-regulation of ceramide biosynthetic process; down-regulation of ceramide formation; down-regulation of ceramide synthesis; downregulation of ceramide anabolism; downregulation of ceramide biosynthesis; downregulation of ceramide biosynthetic process; downregulation of ceramide formation; downregulation of ceramide synthesis; inhibition of ceramide anabolism; inhibition of ceramide biosynthesis; inhibition of ceramide biosynthetic process; inhibition of ceramide formation; inhibition of ceramide synthesis; negative regulation of ceramide anabolism; negative regulation of ceramide biosynthesis; negative regulation of ceramide formation; negative regulation of ceramide synthesis
obsolete regulation of Sertoli cell proliferation (GO:1900083)
Namespace: biological_process
Definition: OBSOLETE. Any process that modulates the frequency, rate or extent of Sertoli cell proliferation.
Synonyms: regulation of Sertoli cell proliferation
Comment: This term was obsoleted at the TermGenie Gatekeeper stage.
negative regulation of peptidyl-tyrosine autophosphorylation (GO:1900085)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.
Synonyms: down regulation of peptidyl-tyrosine autophosphorylation; down regulation of receptor tyrosine kinase autophosphorylation; down regulation of tyrosine autophosphorylation; down-regulation of peptidyl-tyrosine autophosphorylation; down-regulation of receptor tyrosine kinase autophosphorylation; down-regulation of tyrosine autophosphorylation; downregulation of peptidyl-tyrosine autophosphorylation; downregulation of receptor tyrosine kinase autophosphorylation; downregulation of tyrosine autophosphorylation; inhibition of peptidyl-tyrosine autophosphorylation; inhibition of receptor tyrosine kinase autophosphorylation; inhibition of tyrosine autophosphorylation; negative regulation of receptor tyrosine kinase autophosphorylation; negative regulation of tyrosine autophosphorylation
regulation of raffinose biosynthetic process (GO:1900091)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of raffinose biosynthetic process.
Synonyms: regulation of raffinose anabolism; regulation of raffinose biosynthesis; regulation of raffinose formation; regulation of raffinose synthesis
regulation of plasma cell differentiation (GO:1900098)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of plasma cell differentiation.
Synonyms: regulation of plasma cell development
negative regulation of plasma cell differentiation (GO:1900099)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation.
Synonyms: down regulation of plasma cell development; down regulation of plasma cell differentiation; down-regulation of plasma cell development; down-regulation of plasma cell differentiation; downregulation of plasma cell development; downregulation of plasma cell differentiation; inhibition of plasma cell development; inhibition of plasma cell differentiation; negative regulation of plasma cell development
regulation of endoplasmic reticulum unfolded protein response (GO:1900101)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
Synonyms: regulation of ER unfolded protein response; regulation of erUPR; regulation of SREBP-mediated signalling pathway
extracellular regulation of signal transduction (GO:1900115)
Namespace: biological_process
Definition: Any regulation of signal transduction that takes place in the extracellular region.
Synonyms: regulation of signaling pathway in extracellular region; regulation of signalling pathway in extracellular region
extracellular negative regulation of signal transduction (GO:1900116)
Namespace: biological_process
Definition: Any negative regulation of signal transduction that takes place in extracellular region.
Synonyms: down regulation of signal transduction in extracellular region; down-regulation of signal transduction in extracellular region; downregulation of signal transduction in extracellular region; extracellular inhibition of signaling pathway; inhibition of signal transduction in extracellular region; negative regulation of signaling pathway in extracellular region; negative regulation of signalling pathway in extracellular region
regulation of nodal receptor complex assembly (GO:1900123)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of nodal receptor complex assembly.
Synonyms: regulation of ActRIIB.ALK4.EGF-CFC complex formation; regulation of nodal receptor complex formation
negative regulation of hyaluronan biosynthetic process (GO:1900126)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.
Synonyms: down regulation of hyaluronan anabolism; down regulation of hyaluronan biosynthesis; down regulation of hyaluronan biosynthetic process; down regulation of hyaluronan formation; down regulation of hyaluronan synthesis; down-regulation of hyaluronan anabolism; down-regulation of hyaluronan biosynthesis; down-regulation of hyaluronan biosynthetic process; down-regulation of hyaluronan formation; down-regulation of hyaluronan synthesis; downregulation of hyaluronan anabolism; downregulation of hyaluronan biosynthesis; downregulation of hyaluronan biosynthetic process; downregulation of hyaluronan formation; downregulation of hyaluronan synthesis; inhibition of hyaluronan anabolism; inhibition of hyaluronan biosynthesis; inhibition of hyaluronan biosynthetic process; inhibition of hyaluronan formation; inhibition of hyaluronan synthesis; negative regulation of hyaluronan anabolism; negative regulation of hyaluronan biosynthesis; negative regulation of hyaluronan formation; negative regulation of hyaluronan synthesis
obsolete positive regulation of lipid binding (GO:1900132)
Namespace: biological_process
Definition: OBSOLETE. Any process that activates or increases the frequency, rate or extent of lipid binding.
Synonyms: activation of lipid binding; up regulation of lipid binding; up-regulation of lipid binding; upregulation of lipid binding
Comment: This term was obsoleted because it represents a molecular function.
positive regulation of renin secretion into blood stream (GO:1900135)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream.
Synonyms: activation of renin release into blood stream; activation of renin secretion into blood stream; positive regulation of renin release into blood stream; up regulation of renin release into blood stream; up regulation of renin secretion into blood stream; up-regulation of renin release into blood stream; up-regulation of renin secretion into blood stream; upregulation of renin release into blood stream; upregulation of renin secretion into blood stream
obsolete negative regulation of phospholipid scramblase activity (GO:1900162)
Namespace: biological_process
Definition: OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity.
Synonyms: down regulation of phospholipid scramblase activity; down-regulation of phospholipid scramblase activity; downregulation of phospholipid scramblase activity; inhibition of phospholipid scramblase activity
Comment: This term was obsoleted because it represents a molecular function.
positive regulation of single-species biofilm formation (GO:1900192)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of single-species biofilm formation.
Synonyms: activation of single-species biofilm formation; up regulation of single-species biofilm formation; up-regulation of single-species biofilm formation; upregulation of single-species biofilm formation
negative regulation of oocyte maturation (GO:1900194)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.
Synonyms: down regulation of oocyte maturation; down-regulation of oocyte maturation; downregulation of oocyte maturation; inhibition of oocyte maturation
regulation of penicillin biosynthetic process (GO:1900196)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of penicillin biosynthetic process.
Synonyms: regulation of penicillin anabolism; regulation of penicillin biosynthesis; regulation of penicillin formation; regulation of penicillin synthesis
negative regulation of cardiolipin metabolic process (GO:1900209)
Namespace: biological_process
Definition: Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process.
Synonyms: down regulation of cardiolipin metabolic process; down regulation of cardiolipin metabolism; down regulation of diphosphatidylglycerol metabolic process; down regulation of diphosphatidylglycerol metabolism; down-regulation of cardiolipin metabolic process; down-regulation of cardiolipin metabolism; down-regulation of diphosphatidylglycerol metabolic process; down-regulation of diphosphatidylglycerol metabolism; downregulation of cardiolipin metabolic process; downregulation of cardiolipin metabolism; downregulation of diphosphatidylglycerol metabolic process; downregulation of diphosphatidylglycerol metabolism; inhibition of cardiolipin metabolic process; inhibition of cardiolipin metabolism; inhibition of diphosphatidylglycerol metabolic process; inhibition of diphosphatidylglycerol metabolism; negative regulation of cardiolipin metabolism; negative regulation of diphosphatidylglycerol metabolic process; negative regulation of diphosphatidylglycerol metabolism