LiteFold/GO huggingface dataset:
Pi Mi complex (GO:0062071)
Namespace: cellular_component
Definition: A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis.
histone mRNA stem-loop binding complex (GO:0062073)
Namespace: cellular_component
Definition: A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export.
Synonyms: SLBP-MIF4GD complex; SLBP-SLIP1 complex
inhibitory MHC class Ib receptor activity (GO:0062080)
Namespace: molecular_function
Definition: Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte.
positive regulation of taurine biosynthetic process (GO:0062090)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of taurine biosynthesis.
zinc ion import into organelle (GO:0062111)
Namespace: biological_process
Definition: The directed import of zinc(2+) from the cytosol, across an organelle membrane, into the organelle.
obsolete adhesive extracellular matrix (GO:0062130)
Namespace: cellular_component
Definition: OBSOLETE. A extracellular matrix which attaches an organism to a substrate.
Synonyms: puparial glue
Comment: This term was obsoleted because it was too broadly defined. It represents Drosophila 'glue' proteins but this is not clear from the definition.
catalase complex (GO:0062151)
Namespace: cellular_component
Definition: A protein-containing complex that is capable of catalase activity.
curli secretion complex (GO:0062155)
Namespace: cellular_component
Definition: A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms.
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity (GO:0062181)
Namespace: molecular_function
Definition: Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin].
galactoxylomannan biosynthetic process (GO:0062191)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals.
Synonyms: galactoxylomannan anabolism; galactoxylomannan biosynthesis; galactoxylomannan formation; galactoxylomannan synthesis; GalXM biosynthetic process; glucuronoxylomannogalactan biosynthetic process
negative regulation of adult somatic muscle development (GO:0062228)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of adult somatic muscle development.
negative regulation of larval somatic muscle development (GO:0062230)
Namespace: biological_process
Definition: Any process that decreases the rate, frequency or extent of larval somatic muscle development.
armadillo repeat domain binding (GO:0070016)
Namespace: molecular_function
Definition: Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation.
Synonyms: Arm repeat domain binding; armadillo domain binding; armadillo repeat binding
transforming growth factor beta ligand-receptor complex (GO:0070021)
Namespace: cellular_component
Definition: A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand.
Synonyms: TGF-beta 1:type II receptor:type I receptor complex; TGF-beta ligand-receptor complex; TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex; TGF-beta1 ligand-receptor complex; TGF-beta1-beta2 ligand-receptor complex; TGF-beta1-type II receptor-type I receptor complex; TGF-beta2 ligand-receptor complex; TGFb ligand-receptor complex; TGFbeta ligand-receptor complex; TGFbeta1 ligand-receptor complex; TGFbeta1-beta2 ligand-receptor complex; TGFbeta2 ligand-receptor complex; transforming growth factor beta1-type II receptor-type I receptor complex
nitric oxide binding (GO:0070026)
Namespace: molecular_function
Definition: Binding to nitric oxide (NO).
Synonyms: nitrogen monoxide binding; nitrosyl binding; NO binding
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex (GO:0070032)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
Synonyms: SNARE complex (Vamp2, Snap25, Stx1a, Cplx1); Vamp2-Snap25-Stx1a-Cplx1 complex
endobrevin-SNAP-25-syntaxin-1a complex (GO:0070048)
Namespace: cellular_component
Definition: A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof).
Synonyms: SNARE complex (Stx1a, Snap25, Vamp8); Stx1a-Snap25-Vamp8 complex
endobrevin-SNAP-25-syntaxin-2 complex (GO:0070049)
Namespace: cellular_component
Definition: A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof).
Synonyms: SNARE complex (Stx2, Snap25, Vamp8); Stx2-Snap25-Vamp8 complex
proline-rich region binding (GO:0070064)
Namespace: molecular_function
Definition: Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
cytochrome complex (GO:0070069)
Namespace: cellular_component
Definition: A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
ubiquitin-dependent endocytosis (GO:0070086)
Namespace: biological_process
Definition: Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.
Synonyms: ubiquitin-mediated endocytosis
mitochondrial outer membrane translocase complex assembly (GO:0070096)
Namespace: biological_process
Definition: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.
Synonyms: mitochondrion outer membrane translocase complex assembly; TOM complex assembly
delta-catenin binding (GO:0070097)
Namespace: molecular_function
Definition: Binding to the delta subunit of the catenin complex.
interleukin-6-mediated signaling pathway (GO:0070102)
Namespace: biological_process
Definition: The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: IL-6-mediated signaling pathway; interleukin-6-mediated signalling pathway
organellar chromatophore thylakoid lumen (GO:0070117)
Namespace: cellular_component
Definition: The volume enclosed by an organellar chromatophore thylakoid membrane.
Synonyms: Paulinella-type chromatophore thylakoid lumen
obsolete isopeptidase activity (GO:0070122)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond).
Comment: This term was obsoleted because it represents an unnecessary grouping class.
tight junction (GO:0070160)
Namespace: cellular_component
Definition: A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
Synonyms: occluding cell junction; occluding junction
small ribosomal subunit rRNA binding (GO:0070181)
Namespace: molecular_function
Definition: Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.
Synonyms: 18S rRNA binding; SSU rRNA binding
mitochondrial tyrosyl-tRNA aminoacylation (GO:0070184)
Namespace: biological_process
Definition: The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.
growth hormone receptor complex (GO:0070195)
Namespace: cellular_component
Definition: A receptor complex that consists of two identical subunits and binds growth hormone.
sulfide:quinone oxidoreductase activity (GO:0070224)
Namespace: molecular_function
Definition: Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone.
Synonyms: sulfide-quinone reductase activity; sulphide:quinone oxidoreductase activity
Comment: Note that EC:1.8.5.4 describes this reaction as bacterial-specific, but it has also been observed in eukaryotes (PMID:22852582, PMID:10224084).
obsolete sulfur:ferric ion oxidoreductase activity (GO:0070226)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: S-sulfanylglutathione + 4 Fe3+ + 3 H2O = sulfite + 4 Fe2+ + glutathione + 6 H+.
Synonyms: hydrogen sulfide:ferric ion oxidoreductase
Comment: This term was obsoleted because it represents a specific substrate.
regulation of lymphocyte apoptotic process (GO:0070228)
Namespace: biological_process
Definition: Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.
Synonyms: regulation of lymphocyte apoptosis
Comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
regulation of T cell apoptotic process (GO:0070232)
Namespace: biological_process
Definition: Any process that modulates the occurrence or rate of T cell death by apoptotic process.
Synonyms: regulation of programmed cell death of T cells by apoptosis; regulation of T cell apoptosis; regulation of T lymphocyte apoptosis; regulation of T-cell apoptosis; regulation of T-lymphocyte apoptosis
positive regulation of T cell apoptotic process (GO:0070234)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.
Synonyms: activation of T cell apoptosis; positive regulation of programmed cell death of T cells by apoptosis; positive regulation of T cell apoptosis; positive regulation of T lymphocyte apoptosis; positive regulation of T-cell apoptosis; positive regulation of T-lymphocyte apoptosis; stimulation of T cell apoptosis; up regulation of T cell apoptosis; up-regulation of T cell apoptosis; upregulation of T cell apoptosis
negative regulation of activated T cell autonomous cell death (GO:0070240)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death.
Synonyms: down regulation of activated T cell autonomous cell death; down-regulation of activated T cell autonomous cell death; downregulation of activated T cell autonomous cell death; inhibition of activated T cell autonomous cell death; negative regulation of ACAD; negative regulation of activated cell autonomous cell death; negative regulation of activated T cell apoptosis; negative regulation of activated T lymphocyte autonomous cell death; negative regulation of activated T-cell autonomous cell death; negative regulation of activated T-lymphocyte autonomous cell death
mucus secretion (GO:0070254)
Namespace: biological_process
Definition: The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.
Synonyms: mucus production
regulation of mucus secretion (GO:0070255)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
Synonyms: regulation of mucus production
positive regulation of mucus secretion (GO:0070257)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
Synonyms: positive regulation of mucus production
external side of fungal-type cell wall (GO:0070263)
Namespace: cellular_component
Definition: The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents.
necroptotic process (GO:0070266)
Namespace: biological_process
Definition: A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
Synonyms: activation of necroptosis; activation of necroptosis by extracellular signals; activation of necroptosis in response to extracellular signals; activation of necroptosis of activated-T cells; establishment of necroptosis; establishment of necroptosis of activated-T cells; extracellular signal-induced necroptosis; induction of necroptosis; induction of necroptosis by extracellular signals; induction of necroptosis of activated-T cells; necroptosis; PARP-dependent cell death; parthanatos; programmed necrosis; programmed necrotic cell death; RIPK1-mediated regulated necrosis; TNF-induced necroptosis
Comment: Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
obsolete iodide oxidation (GO:0070277)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons.
Comment: This term was obsoleted because it represents a molecular function.
extracellular matrix constituent secretion (GO:0070278)
Namespace: biological_process
Definition: The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell.
Synonyms: ECM constituent secretion; ECM secretion
ferritin complex (GO:0070288)
Namespace: cellular_component
Definition: A protein complex that binds iron and acts as a major iron storage system. There are three major subclasses of ferritins: the classical ferritins (Ftn), the heme-containing bacterioferritins (Bfr) and the DNA-binding proteins from starved cells (Dps). Ftn and Bfr are made of 24 subunits, whereas Dps are smaller with 12 subunits. Ftn is found in most kindoms, while Bfr and Dps are restricted to prokaryotes.
N-acylethanolamine metabolic process (GO:0070291)
Namespace: biological_process
Definition: The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group.
Synonyms: N-acylethanolamine metabolism; NAE metabolic process; NAE metabolism
negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms: down regulation of stress-activated protein kinase signaling pathway; down-regulation of stress-activated protein kinase signaling pathway; downregulation of stress-activated protein kinase signaling pathway; inhibition of stress-activated protein kinase signaling pathway; negative regulation of SAPK signaling pathway; negative regulation of stress-activated protein kinase signaling pathway; negative regulation of stress-activated protein kinase signalling pathway
lens fiber cell differentiation (GO:0070306)
Namespace: biological_process
Definition: The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
Synonyms: lens fibre cell differentiation
positive regulation of fat cell proliferation (GO:0070346)
Namespace: biological_process
Definition: Any process that activates or increases the rate or extent of fat cell proliferation.
Synonyms: activation of fat cell proliferation; positive regulation of adipocyte proliferation; positive regulation of adipose cell proliferation; stimulation of fat cell proliferation; up regulation of fat cell proliferation; up-regulation of fat cell proliferation; upregulation of fat cell proliferation
regulation of brown fat cell proliferation (GO:0070347)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of brown fat cell proliferation.
Synonyms: regulation of brown adipocyte proliferation; regulation of brown adipose cell proliferation
regulation of white fat cell proliferation (GO:0070350)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of white fat cell proliferation.
Synonyms: regulation of white adipocyte proliferation; regulation of white adipose cell proliferation
negative regulation of white fat cell proliferation (GO:0070351)
Namespace: biological_process
Definition: Any process that stops or decreases the rate or extent of white fat cell proliferation.
Synonyms: down regulation of white fat cell proliferation; down-regulation of white fat cell proliferation; downregulation of white fat cell proliferation; inhibition of white fat cell proliferation; negative regulation of white adipocyte proliferation; negative regulation of white adipose cell proliferation
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex (GO:0070356)
Namespace: cellular_component
Definition: A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof).
Synonyms: SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2); STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex
beta-catenin-TCF7L2 complex (GO:0070369)
Namespace: cellular_component
Definition: A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.
Synonyms: beta-catenin-TCF4 complex
positive regulation of ERK1 and ERK2 cascade (GO:0070374)
Namespace: biological_process
Definition: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Synonyms: activation of ERK1 and ERK2 cascade; positive regulation of ERK cascade; positive regulation of ERK1 and ERK2 signaling pathway; positive regulation of ERK1 and ERK2 signalling pathway; positive regulation of ERK1 cascade; positive regulation of ERK1/2 cascade; positive regulation of ERK2 cascade; positive regulation of MAPK1 cascade; positive regulation of MAPK3 cascade; stimulation of ERK1 and ERK2 cascade; up regulation of ERK1 and ERK2 cascade; up-regulation of ERK1 and ERK2 cascade; upregulation of ERK1 and ERK2 cascade
high mobility group box 1 receptor activity (GO:0070380)
Namespace: molecular_function
Definition: Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: HMGB1 receptor activity
procollagen-proline 4-dioxygenase complex, alpha(I) type (GO:0070386)
Namespace: cellular_component
Definition: A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline).
Synonyms: procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type; prolyl 4-hydroxylase complex (alpha(I)-type)
response to lipoteichoic acid (GO:0070391)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
Synonyms: response to LTA
lipoteichoic acid biosynthetic process (GO:0070395)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
Synonyms: lipoteichoic acid anabolism; lipoteichoic acid biosynthesis; lipoteichoic acid formation; lipoteichoic acid synthesis; LTA biosynthetic process
cellular response to cold (GO:0070417)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
Synonyms: cellular response to cold stress
DNA-dependent protein kinase complex (GO:0070418)
Namespace: cellular_component
Definition: A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.
Synonyms: DNA-dependent protein kinase, DNA-end-binding complex; DNA-PK complex; DNA-PK-Ku antigen complex
Ku-DNA ligase complex (GO:0070420)
Namespace: cellular_component
Definition: A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria.
Grb2-Shc complex (GO:0070437)
Namespace: cellular_component
Definition: A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway.
Synonyms: Grb2-Shc complex, EGF stimulated
elongin complex (GO:0070449)
Namespace: cellular_component
Definition: A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits.
Synonyms: elongin (SIII) complex; transcription elongation factor SIII complex; transcription factor B (SIII) complex
Comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.