LiteFold/GO huggingface dataset:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway (GO:0007188)
Namespace: biological_process
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
Synonyms: adenylate cyclase-modulating GPCR signaling pathway; G protein signaling, coupled to cAMP nucleotide second messenger; G protein signaling, coupled to cyclic AMP nucleotide second messenger; G protein signalling, coupled to cAMP nucleotide second messenger; G protein signalling, coupled to cyclic AMP nucleotide second messenger; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic AMP nucleotide second messenger; G-protein signalling, coupled to cAMP nucleotide second messenger; G-protein signalling, coupled to cyclic AMP nucleotide second messenger; GPCR signaling pathway via cAMP second messenger; GPCR signaling pathway via modulation of adenylate cyclase activity
Comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway ; GO:0010578.
obsolete protein kinase C-activating G protein-coupled receptor signaling pathway (GO:0007205)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
Synonyms: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway; protein kinase C-activating G-protein coupled receptor signaling pathway
Comment: This term was obsoleted because it represents the same pathway as phospholipase C-activating G protein-coupled receptor signaling pathway ; GO:0007200.
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway (GO:0007206)
Namespace: biological_process
Definition: A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms: activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway; activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway; activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway; metabotropic glutamate receptor, phospholipase C activating pathway; phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
obsolete nuclear translocation of Hog1 (GO:0007240)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: nuclear translocation of Hog1
Comment: This term was made obsolete because it contains gene product and species specific information.
tyrosine phosphorylation of STAT protein (GO:0007260)
Namespace: biological_process
Definition: The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
Synonyms: tyrosine phosphorylation of Stat1 protein; tyrosine phosphorylation of Stat2 protein; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat4 protein; tyrosine phosphorylation of Stat5 protein; tyrosine phosphorylation of Stat6 protein; tyrosine phosphorylation of Stat7 protein
neurotransmitter secretion (GO:0007269)
Namespace: biological_process
Definition: The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
Synonyms: neurotransmitter release; neurotransmitter secretory pathway
Comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
growth of a germarium-derived egg chamber (GO:0007295)
Namespace: biological_process
Definition: Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster.
Synonyms: egg chamber growth
obsolete positive regulation of transcription from RNA polymerase II promoter by pheromones (GO:0007329)
Namespace: biological_process
Definition: OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter.
Synonyms: activation of transcription from RNA polymerase II promoter by pheromones; positive regulation of transcription from Pol II promoter by pheromones; stimulation of transcription from RNA polymerase II promoter by pheromones; up regulation of transcription from RNA polymerase II promoter by pheromones; up-regulation of transcription from RNA polymerase II promoter by pheromones; upregulation of transcription from RNA polymerase II promoter by pheromones
Comment: This term has been obsoleted because it represents a GO-CAM model.
regulation of syncytial blastoderm mitotic cell cycle (GO:0007348)
Namespace: biological_process
Definition: A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle.
Synonyms: modulation of syncytial blastoderm cell cycle progression; regulation of progression through syncytial blastoderm mitotic cell cycle; regulation of syncytial blastoderm cell cycle; regulation of syncytial blastoderm cell cycle progression; syncytial blastoderm cell cycle modulation; syncytial blastoderm cell cycle regulation; syncytial blastoderm cell cycle regulator
obsolete positive regulation of posterior gap gene transcription (GO:0007360)
Namespace: biological_process
Definition: OBSOLETE. The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene.
Synonyms: activation of posterior gap gene; activation of posterior gap gene transcription; knirps activation; stimulation of posterior gap gene transcription; up regulation of posterior gap gene transcription; up-regulation of posterior gap gene transcription; upregulation of posterior gap gene transcription
Comment: This term was obsoleted because it represents a GO-CAM model.
obsolete establishment of posterior gap gene boundaries (GO:0007361)
Namespace: biological_process
Definition: OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps.
Comment: This term has been obsoleted because it represents a transcriptional feedback loop covered by other processes.
anterior midgut invagination (GO:0007375)
Namespace: biological_process
Definition: Internalization of the anterior midgut into the interior of the embryo.
secondary branching, open tracheal system (GO:0007429)
Namespace: biological_process
Definition: Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster.
Synonyms: secondary tracheal branching
imaginal disc development (GO:0007444)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.).
imaginal disc pattern formation (GO:0007447)
Namespace: biological_process
Definition: The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.
dorsal/ventral lineage restriction, imaginal disc (GO:0007451)
Namespace: biological_process
Definition: Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment.
Synonyms: dorsal-ventral lineage restriction, imaginal disc; dorsoventral lineage restriction, imaginal disc
R7 cell fate commitment (GO:0007465)
Namespace: biological_process
Definition: The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
imaginal disc-derived wing vein specification (GO:0007474)
Namespace: biological_process
Definition: The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
Synonyms: wing vein specification
leg disc morphogenesis (GO:0007478)
Namespace: biological_process
Definition: The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura.
Synonyms: leg disc metamorphosis
imaginal disc-derived female genitalia development (GO:0007486)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.
Synonyms: female genital development
tergite morphogenesis (GO:0007490)
Namespace: biological_process
Definition: The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment.
sternite morphogenesis (GO:0007491)
Namespace: biological_process
Definition: The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment.
mesodermal cell fate determination (GO:0007500)
Namespace: biological_process
Definition: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.
Synonyms: mesoderm cell fate determination
Comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'.
somatic muscle development (GO:0007525)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
obsolete maintenance of dosage compensation (GO:0007551)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: maintenance of dosage compensation
Comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms.
eclosion (GO:0007562)
Namespace: biological_process
Definition: The emergence of an adult insect from a pupa case.
regulation of chitin-based cuticle tanning (GO:0007564)
Namespace: biological_process
Definition: Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning.
Synonyms: regulation of cuticle hardening; regulation of cuticle tanning
female pregnancy (GO:0007565)
Namespace: biological_process
Definition: The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
Synonyms: carrying of young; gestation
obsolete protein-based cuticle development (GO:0007592)
Namespace: biological_process
Definition: OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans.
Synonyms: protein-based cuticle anabolism; protein-based cuticle biosynthetic process; protein-based cuticle development; protein-based cuticle formation; protein-based cuticle synthesis
Comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term.
lactation (GO:0007595)
Namespace: biological_process
Definition: The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
Synonyms: milk secretion
sensory perception of chemical stimulus (GO:0007606)
Namespace: biological_process
Definition: The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
Synonyms: chemosensory perception
courtship behavior (GO:0007619)
Namespace: biological_process
Definition: The behavior of an organism for the purpose of attracting sexual partners.
Synonyms: courtship behaviour
locomotory behavior (GO:0007626)
Namespace: biological_process
Definition: The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
Synonyms: behavior via locomotion; locomotion in response to stimulus; locomotory behavioral response to stimulus; locomotory behaviour; locomotory behavioural response to stimulus
adult walking behavior (GO:0007628)
Namespace: biological_process
Definition: The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
Synonyms: adult walking behaviour
jump response (GO:0007630)
Namespace: biological_process
Definition: The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.
chemosensory jump behavior (GO:0007636)
Namespace: biological_process
Definition: The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance.
Synonyms: chemosensory jump behaviour; jump response to chemical stimulus
transcription elongation factor complex (GO:0008023)
Namespace: cellular_component
Definition: Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
neuronal pentraxin receptor activity (GO:0008030)
Namespace: molecular_function
Definition: Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
Synonyms: neuronal pentaxin receptor
obsolete iron-sulfur electron transfer carrier (GO:0008042)
Namespace: molecular_function
Definition: OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system.
Synonyms: ferredoxin; iron-sulfur electron transfer carrier; iron-sulphur electron transfer carrier
Comment: This term was made obsolete because it refers to a class of gene products.
motor neuron axon guidance (GO:0008045)
Namespace: biological_process
Definition: The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
Synonyms: motoneuron axon guidance; motor axon guidance; motor axon pathfinding
chitin binding (GO:0008061)
Namespace: molecular_function
Definition: Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
translation termination factor activity (GO:0008079)
Namespace: molecular_function
Definition: Functions in the termination of translation.
growth factor activity (GO:0008083)
Namespace: molecular_function
Definition: The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
Comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.
imaginal disc growth factor receptor binding (GO:0008084)
Namespace: molecular_function
Definition: Binding to an imaginal disc growth factor receptor.
Synonyms: imaginal disc growth factor
obsolete phototransduction, visible light, light adaptation (GO:0008085)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: phototransduction, visible light, light adaptation
Comment: This term was made obsolete because the term name is ambiguous.
light-activated voltage-gated calcium channel activity (GO:0008086)
Namespace: molecular_function
Definition: Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Synonyms: light-activated voltage gated calcium channel activity; light-activated voltage-dependent calcium channel activity
alcohol dehydrogenase (NADP+) activity (GO:0008106)
Namespace: molecular_function
Definition: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or ketone + NADPH + H+.
Synonyms: alcohol:NADP dehydrogenase activity; aldehyde reductase (NADPH) activity; NADP-aldehyde reductase activity
galactoside 2-alpha-L-fucosyltransferase activity (GO:0008107)
Namespace: molecular_function
Definition: Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R.
Synonyms: alpha(1,2)-L-fucosyltransferase activity; alpha-(1->2)-L-fucosyltransferase activity; alpha-2-fucosyltransferase activity; alpha-2-L-fucosyltransferase activity; beta-galactoside alpha-1->2 fucosyltransferase activity; beta-galactoside alpha1->2 fucosyltransferase activity; blood group H alpha-2-fucosyltransferase activity; blood-group substance H-dependent fucosyltransferase activity; galactoside 2-L-fucosyltransferase activity; GDP fucose-lactose fucosyltransferase activity; GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity; GDP-L-fucose:lactose fucosyltransferase activity; guanosine diphospho-L-fucose-lactose fucosyltransferase activity; guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity; guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity; guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity; guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity; guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity; guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity; guanosine diphosphofucose-lactose fucosyltransferase activity; H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity; H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity; secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity; secretor-type beta-galactoside alpha1->2 fucosyltransferase activity
nicotinamide N-methyltransferase activity (GO:0008112)
Namespace: molecular_function
Definition: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine.
Synonyms: nicotinamide methyltransferase activity; S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity
peptide-methionine (S)-S-oxide reductase activity (GO:0008113)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol.
Synonyms: methionine sulfoxide (protein) reductase activity; peptide-methionine-(S)-S-oxide reductase activity; protein-methionine-S-oxide reductase activity
obsolete pancreatic elastase I activity (GO:0008125)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa.
Synonyms: elaszym; pancreatic elastase I activity; pancreatopeptidase E activity; serine elastase
Comment: This term was made obsolete because it represents a gene product.
obsolete neutrophil collagenase activity (GO:0008130)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
Synonyms: matrix metalloproteinase 8 activity; MMP-8; neutrophil collagenase activity; PMNL collagenase activity
Comment: This term was made obsolete because it represents a gene product.
translation factor activity, RNA binding (GO:0008135)
Namespace: molecular_function
Definition: Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
Synonyms: translation factor activity, nucleic acid binding
cAMP response element binding protein binding (GO:0008140)
Namespace: molecular_function
Definition: Binding to a cAMP response element binding protein (a CREB protein).
Synonyms: 3',5' cAMP response element binding protein binding; 3',5'-cAMP response element binding protein binding; adenosine 3',5'-cyclophosphate response element binding protein binding; CBP; CREB binding; cyclic AMP response element binding protein binding
obsolete puparial glue (sensu Diptera) (GO:0008141)
Namespace: molecular_function
Definition: OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147).
Synonyms: puparial glue (sensu Diptera)
Comment: This term was made obsolete because it represents a gene product and not a molecular function.
actin polymerization or depolymerization (GO:0008154)
Namespace: biological_process
Definition: Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
obsolete larval behavior (sensu Drosophila) (GO:0008155)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: larval behavior (sensu Drosophila)
Comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
obsolete DDT resistance (GO:0008163)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: DDT resistance
Comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
obsolete pyrethroid resistance (GO:0008165)
Namespace: biological_process
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: pyrethroid resistance
Comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.