LiteFold/GO huggingface dataset:
obsolete axon part (GO:0033267)
Namespace: cellular_component
Definition: OBSOLETE. A part of an axon, a cell projection of a neuron.
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
paranode region of axon (GO:0033270)
Namespace: cellular_component
Definition: An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.
Synonyms: paranode
TAT protein transport complex (GO:0033281)
Namespace: cellular_component
Definition: A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.
Synonyms: TAT protein secretion complex; TAT protein translocation system complex; Twin-arginine translocation complex
intraconoid microtubule (GO:0033289)
Namespace: cellular_component
Definition: A microtubule located such that it threads through the conoid and projects through the polar ring.
ectoine binding (GO:0033294)
Namespace: molecular_function
Definition: Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid.
dehydroascorbic acid transmembrane transporter activity (GO:0033300)
Namespace: molecular_function
Definition: Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.
Synonyms: dehydroascorbate transporter activity; dehydroascorbic acid transporter activity
phytol salvage (GO:0033307)
Namespace: biological_process
Definition: A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis.
Synonyms: phytol salvage pathway
UDP-D-xylose biosynthetic process (GO:0033320)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate.
Synonyms: UDP-D-xylose anabolism; UDP-D-xylose biosynthesis; UDP-D-xylose formation; UDP-D-xylose synthesis
pectoral fin development (GO:0033339)
Namespace: biological_process
Definition: The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.
tetrose metabolic process (GO:0033347)
Namespace: biological_process
Definition: The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule.
Synonyms: tetrose metabolism
ascorbate glutathione cycle (GO:0033355)
Namespace: biological_process
Definition: A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges H2O2 and reduces it to water, with concomitant oxidation of NADPH.
Synonyms: hydrogen peroxide detoxification
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway (GO:0033362)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps.
Synonyms: lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway; lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway; lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway; lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
protein localization to organelle (GO:0033365)
Namespace: biological_process
Definition: A process in which a protein is transported to, or maintained in, a location within an organelle.
Synonyms: protein localisation to organelle; protein localization in organelle
protease localization to T cell secretory granule (GO:0033375)
Namespace: biological_process
Definition: Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell.
Synonyms: protease localisation in T cell secretory granule; protease localization in T cell secretory granule; protease localization in T lymphocyte secretory granule; protease localization in T-cell secretory granule; protease localization in T-lymphocyte secretory granule
geranylgeranyl diphosphate metabolic process (GO:0033385)
Namespace: biological_process
Definition: The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins.
Synonyms: geranylgeranyl diphosphate metabolism; geranylgeranyldiphosphate metabolic process
geranylgeranyl diphosphate biosynthetic process (GO:0033386)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.
Synonyms: geranylgeranyl diphosphate anabolism; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate formation; geranylgeranyl diphosphate synthesis
obsolete beta-alanine biosynthetic process via 3-ureidopropionate (GO:0033396)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate.
Synonyms: beta-alanine anabolism via 3-ureidopropionate; beta-alanine formation via 3-ureidopropionate; beta-alanine synthesis via 3-ureidopropionate
Comment: The reason for obsoletion is that this term represents a GO-CAM model.
zeatin biosynthetic process (GO:0033398)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol.
Synonyms: zeatin anabolism; zeatin biosynthesis; zeatin formation; zeatin synthesis
UUA codon-amino acid adaptor activity (GO:0033403)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a UUA codon.
Synonyms: leucine tRNA; TTA codon-amino acid adaptor activity
Comment: Note that in the standard genetic code, TTA codes for leucine.
UCA codon-amino acid adaptor activity (GO:0033407)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a UCA codon.
Synonyms: serine tRNA; TCA codon-amino acid adaptor activity
Comment: Note that in the standard genetic code, TCA codes for serine.
UCG codon-amino acid adaptor activity (GO:0033408)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a UCG codon.
Synonyms: serine tRNA; TCG codon-amino acid adaptor activity
Comment: Note that in the standard genetic code, TCG codes for serine.
CUU codon-amino acid adaptor activity (GO:0033417)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a CUU codon.
Synonyms: CTT codon-amino acid adaptor activity; leucine tRNA
Comment: Note that in the standard genetic code, CTT codes for leucine.
CCA codon-amino acid adaptor activity (GO:0033423)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a CCA codon.
Synonyms: proline tRNA
Comment: Note that in the standard genetic code, CCA codes for proline.
CCG codon-amino acid adaptor activity (GO:0033424)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a CCG codon.
Synonyms: proline tRNA
Comment: Note that in the standard genetic code, CCG codes for proline.
CAG codon-amino acid adaptor activity (GO:0033428)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a CAG codon.
Synonyms: glutamine tRNA
Comment: Note that in the standard genetic code, CAG codes for glutamine.
CGA codon-amino acid adaptor activity (GO:0033431)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a CGA codon.
Synonyms: arginine tRNA
Comment: Note that in the standard genetic code, CGA codes for arginine.
AUA codon-amino acid adaptor activity (GO:0033435)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes an AUA codon.
Synonyms: ATA codon-amino acid adaptor activity; isoleucine tRNA
Comment: Note that in the standard genetic code, ATA codes for isoleucine.
AUG codon-amino acid adaptor activity (GO:0033436)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes an AUG codon.
Synonyms: ATG codon-amino acid adaptor activity; initiator methionine tRNA; methionine tRNA
Comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon.
AAU codon-amino acid adaptor activity (GO:0033441)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes an AAU codon.
Synonyms: AAT codon-amino acid adaptor activity; asparagine tRNA
Comment: Note that in the standard genetic code, AAT codes for asparagine.
AAC codon-amino acid adaptor activity (GO:0033442)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes an AAC codon.
Synonyms: asparagine tRNA
Comment: Note that in the standard genetic code, AAC codes for asparagine.
GUU codon-amino acid adaptor activity (GO:0033449)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a GUU codon.
Synonyms: GTT codon-amino acid adaptor activity; valine tRNA
Comment: Note that in the standard genetic code, GTT codes for valine.
GUA codon-amino acid adaptor activity (GO:0033451)
Namespace: molecular_function
Definition: A triplet codon-amino acid adaptor activity that recognizes a GUA codon.
Synonyms: GTA codon-amino acid adaptor activity; valine tRNA
Comment: Note that in the standard genetic code, GTA codes for valine.
obsolete GDP-L-galactose metabolic process (GO:0033471)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate.
Synonyms: GDP-L-galactose metabolism
Comment: This term was obsoleted because it is an unnecessary grouping term.
indoleacetic acid conjugate biosynthetic process (GO:0033474)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule.
Synonyms: IAA conjugate biosynthetic process; indole acetic acid conjugate biosynthesis; indole acetic acid conjugate biosynthetic process; indoleacetic acid conjugate anabolism; indoleacetic acid conjugate biosynthesis; indoleacetic acid conjugate formation; indoleacetic acid conjugate synthesis
obsolete L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine (GO:0033516)
Namespace: biological_process
Definition: OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine.
Synonyms: L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine; L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine; L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine; methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine
Comment: The reason for obsoletion is that this term is a duplicate of GO:0019283 and was added in error.
fatty acid beta-oxidation, unsaturated, even number (GO:0033542)
Namespace: biological_process
Definition: A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway (GO:0033543)
Namespace: biological_process
Definition: A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
high-affinity iron permease complex (GO:0033573)
Namespace: cellular_component
Definition: A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
Synonyms: high affinity iron permease complex
response to testosterone (GO:0033574)
Namespace: biological_process
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
Synonyms: response to testosterone stimulus
obsolete protein glycosylation in Golgi (GO:0033578)
Namespace: biological_process
Definition: OBSOLETE. The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus.
Synonyms: protein amino acid glycosylation in Golgi; terminal glycosylation
obsolete protein galactosylation in Golgi (GO:0033581)
Namespace: biological_process
Definition: OBSOLETE. The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus.
Synonyms: protein amino acid galactosylation in Golgi
mammary gland epithelial cell proliferation (GO:0033598)
Namespace: biological_process
Definition: The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
oxalate catabolic process (GO:0033611)
Namespace: biological_process
Definition: The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate.
Synonyms: ethanedioate catabolic process; ethanedioic acid catabolic process; oxalate breakdown; oxalate catabolism; oxalate degradation; oxalic acid catabolic process
negative regulation of integrin activation (GO:0033624)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation.
Synonyms: negative regulation of integrin complex activation
obsolete modulation by symbiont of host response to osmotic stress (GO:0033640)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete modulation by symbiont of host response to gravitational stimulus (GO:0033642)
Namespace: biological_process
Definition: OBSOLETE. Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Synonyms: response to gravitational stimulus
Comment: This term was obsoleted because there is no evidence that this process exists.
obsolete modulation by symbiont of host defense-related protein level (GO:0033662)
Namespace: biological_process
Definition: OBSOLETE. The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
obsolete negative regulation by symbiont of host defense-related protein level (GO:0033663)
Namespace: biological_process
Definition: OBSOLETE. Any process in which the symbiont reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms.
negative regulation of kinase activity (GO:0033673)
Namespace: biological_process
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
Synonyms: down regulation of kinase activity; down-regulation of kinase activity; downregulation of kinase activity; inhibition of kinase activity; kinase inhibitor
GDP-4-dehydro-6-deoxy-D-mannose reductase activity (GO:0033705)
Namespace: molecular_function
Definition: Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+.
Synonyms: GDP-4-keto-6-deoxy-D-mannose reductase activity; GDP-6-deoxy-D-lyxo-4-hexulose reductase activity; GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity; Rmd
Comment: Note that this enzyme differs from EC:1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose).
obsolete quinate/shikimate dehydrogenase activity (GO:0033706)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+, and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+.
Synonyms: L-quinate:NAD(P)+ 3-oxidoreductase activity; quinate/shikimate dehydrogenase activity; YdiB
Comment: This term was made obsolete because it represents four reactions, and should be four separate terms.
isocitrate-homoisocitrate dehydrogenase activity (GO:0033708)
Namespace: molecular_function
Definition: Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+.
Synonyms: homoisocitrate-isocitrate dehydrogenase activity; isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity; PH1722
nucleoside oxidase (hydrogen peroxide-forming) activity (GO:0033716)
Namespace: molecular_function
Definition: Catalysis of the reaction: adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 + H+.
Synonyms: nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity
Comment: Two other reactions might be associated with this activity: (1a) adenosine + O2 = 5'-dehydroadenosine + hydrogen peroxide, and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + hydrogen peroxide.
malonate-semialdehyde dehydrogenase activity (GO:0033722)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+.
Synonyms: 3-oxopropanoate:NAD(P)+ oxidoreductase activity; malonic semialdehyde dehydrogenase activity
aldehyde dehydrogenase (FAD-independent) activity (GO:0033727)
Namespace: molecular_function
Definition: Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor.
Synonyms: aldehyde oxidoreductase activity; aldehyde:acceptor oxidoreductase (FAD-independent) activity; AORDd; Mop
anthocyanidin reductase activity (GO:0033729)
Namespace: molecular_function
Definition: Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+.
Synonyms: ANR; AtANR; flavan-3-ol:NAD(P)+ oxidoreductase activity; MtANR
arogenate dehydrogenase [NAD(P)+] activity (GO:0033731)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2.
Synonyms: arogenic dehydrogenase activity; L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity; pretyrosine dehydrogenase activity
histone H3R2 demethylase activity (GO:0033746)
Namespace: molecular_function
Definition: Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
Synonyms: histone demethylase activity (H3-R2 specific); histone H3-methyl-arginine-2 demethylase activity; histone H3-R2 demethylase activity; histone H3R2me demethylase activity
Comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
indoleamine 2,3-dioxygenase activity (GO:0033754)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-tryptophan + O2 = N-formyl-D-kynurenine.
Synonyms: D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity; IDO; tryptophan pyrrolase activity
2'-deoxymugineic-acid 2'-dioxygenase activity (GO:0033760)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + H+ + mugineate + succinate.
Synonyms: 2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity; IDS3
sarcosine reductase activity (GO:0033794)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin.
Synonyms: acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity
flavonol-3-O-triglucoside O-coumaroyltransferase activity (GO:0033811)
Namespace: molecular_function
Definition: Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside].
Synonyms: 4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity
biphenyl synthase activity (GO:0033815)
Namespace: molecular_function
Definition: Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2.
Synonyms: BIS; malonyl-CoA:benzoyl-CoA malonyltransferase activity
diaminobutyrate acetyltransferase activity (GO:0033816)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H+.
Synonyms: 2,4-diaminobutanoate acetyltransferase activity; acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity; acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity; DAB acetyltransferase activity; DABA acetyltransferase activity; DABAcT; diaminobutyric acid acetyltransferase activity; EctA; L-2,4-diaminobutanoate acetyltransferase activity; L-2,4-diaminobutyrate acetyltransferase activity