LiteFold/GO huggingface dataset:
obsolete fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation (GO:0003268)
Namespace: biological_process
Definition: OBSOLETE. The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
Synonyms: fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation; fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation; fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation
Comment: This term was obsoleted because it represents a GO-CAM model.
atrial septum secundum morphogenesis (GO:0003290)
Namespace: biological_process
Definition: The process in which anatomical structure of an atrial septum secundum is generated and organized.
atrial septum intermedium morphogenesis (GO:0003291)
Namespace: biological_process
Definition: The process in which anatomical structure of an atrial septum intermedium is generated and organized.
heart valve cell differentiation (GO:0003293)
Namespace: biological_process
Definition: The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve.
heart rudiment formation (GO:0003315)
Namespace: biological_process
Definition: The developmental process pertaining to the initial formation of the heart rudiment.
Synonyms: heart cone formation
brainstem development (GO:0003360)
Namespace: biological_process
Definition: The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.
establishment of cell polarity involved in gastrulation cell migration (GO:0003379)
Namespace: biological_process
Definition: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.
neural retina development (GO:0003407)
Namespace: biological_process
Definition: The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
obsolete chondrocyte morphogenesis involved in endochondral bone morphogenesis (GO:0003414)
Namespace: biological_process
Definition: OBSOLETE. The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
chondrocyte intercalation involved in growth plate cartilage morphogenesis (GO:0003428)
Namespace: biological_process
Definition: The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone.
obsolete cell growth involved in growth plate cartilage chondrocyte morphogenesis (GO:0003432)
Namespace: biological_process
Definition: OBSOLETE. The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time.
Comment: This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
minor groove of adenine-thymine-rich DNA binding (GO:0003680)
Namespace: molecular_function
Definition: Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.
Synonyms: AT binding; AT DNA binding; AT-rich DNA binding
obsolete DNA repair enzyme (GO:0003686)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: DNA repair enzyme
Comment: This term was made obsolete because it includes a process term.
obsolete ligand-regulated transcription factor activity (GO:0003706)
Namespace: molecular_function
Definition: OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand.
Synonyms: ligand-regulated transcription factor activity
Comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism.
obsolete RNA polymerase III transcription termination factor activity (GO:0003718)
Namespace: molecular_function
Definition: OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III.
Synonyms: Pol III transcription termination factor activity; RNA polymerase III transcription termination factor activity
Comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
obsolete cell cycle regulator (GO:0003750)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: cell cycle regulator
Comment: This term was made obsolete because it does not represent a single molecular function.
obsolete co-chaperone activity (GO:0003767)
Namespace: molecular_function
Definition: OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity.
Synonyms: co-chaperone activity
Comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
obsolete antibacterial peptide activity (GO:0003797)
Namespace: molecular_function
Definition: OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells.
Synonyms: antibacterial peptide activity
Comment: This term was made obsolete because it describes involvement in a process and not a function.
obsolete antiviral response protein activity (GO:0003800)
Namespace: molecular_function
Definition: OBSOLETE. A protein involved in an antiviral response.
Synonyms: antiviral response protein activity
Comment: This term was made obsolete because it refers to involvement in a biological process.
obsolete complement component C1s activity (GO:0003816)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).
Synonyms: activated complement C1s; C1 esterase activity; C1s esterase activity; complement C1s; complement component C1s activity; complement subcomponent C1s
Comment: This term was made obsolete because it represents a gene product.
beta-alanyl-dopamine hydrolase activity (GO:0003832)
Namespace: molecular_function
Definition: Catalysis of the reaction: beta-alanyl-dopamine + H2O = dopamine + beta-alanine.
Synonyms: N-beta-alanyl-dopamine hydrolase activity; NBAD hydrolase activity
beta-alanyl amine synthase activity (GO:0003833)
Namespace: molecular_function
Definition: Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine.
Synonyms: beta-alanyl-dopamine synthase activity; N-beta-alanyl dopamine synthetase activity; NBAD transferase activity
obsolete DNA-directed RNA polymerase III activity (GO:0003902)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Synonyms: DNA-directed RNA polymerase III activity
Comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'.
DNA topoisomerase type I (single strand cut, ATP-independent) activity (GO:0003917)
Namespace: molecular_function
Definition: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
Synonyms: deoxyribonucleate topoisomerase; DNA topoisomerase I activity; nicking-closing enzyme activity; omega-protein activity; relaxing enzyme activity; swivelase activity; topoisomerase; type I DNA topoisomerase activity; type I topoisomerase activity; untwisting enzyme activity
Comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity (GO:0003944)
Namespace: molecular_function
Definition: Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose.
Synonyms: 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity; alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity; alpha-N-acetylglucosaminyl phosphodiesterase activity; glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity; lysosomal alpha-N-acetylglucosaminidase activity; phosphodiester glycosidase activity
(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity (GO:0003947)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.
Synonyms: asialo-GM2 synthase activity; beta-1,4N-aetylgalactosaminyltransferase activity; GalNAc-T activity; ganglioside GM2 synthase activity; ganglioside GM3 acetylgalactosaminyltransferase activity; GM2 synthase activity; GM2/GD2-synthase activity; UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity; UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity; UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity; UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity; uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity; uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity; uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity (GO:0003975)
Namespace: molecular_function
Definition: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
Synonyms: chitobiosylpyrophosphoryldolichol synthase activity; dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity; GlcNAc-1-P transferase activity; N-acetylglucosamine-1-phosphate transferase activity; UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity; UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity; UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity; UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity; UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity; UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity; uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity (GO:0003992)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
Synonyms: 2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; acetylornithine 5-aminotransferase activity; acetylornithine aminotransferase activity; acetylornithine delta-transaminase activity; acetylornithine transaminase activity; ACOAT activity; N(2)-acetylornithine 5-transaminase activity; N-acetylornithine aminotransferase activity; N-acetylornithine-delta-transaminase activity; N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity; N2-acetylornithine 5-aminotransferase activity; N2-acetylornithine 5-transaminase activity; succinylornithine aminotransferase activity
acyl-CoA oxidase activity (GO:0003997)
Namespace: molecular_function
Definition: Catalysis of the reaction: a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.
Synonyms: acyl coenzyme A oxidase activity; acyl-CoA:oxygen 2-oxidoreductase activity; fatty acyl-CoA oxidase activity; fatty acyl-coenzyme A oxidase activity
adenosine kinase activity (GO:0004001)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP + adenosine = ADP + AMP.
Synonyms: adenosine 5-phosphotransferase activity; adenosine kinase (phosphorylating); ATP:adenosine 5'-phosphotransferase activity
adenylate cyclase activity (GO:0004016)
Namespace: molecular_function
Definition: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
Synonyms: 3',5'-cyclic AMP synthetase activity; adenyl cyclase activity; adenylyl cyclase activity; adenylylcyclase activity; ATP diphosphate-lyase (cyclizing) activity; ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity; ATP pyrophosphate-lyase activity; cAMP generating peptide activity
alcohol O-acetyltransferase activity (GO:0004026)
Namespace: molecular_function
Definition: Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.
Synonyms: AATASE activity; acetyl-CoA:alcohol O-acetyltransferase activity; alcohol acetyltransferase activity
dihydroxy-acid dehydratase activity (GO:0004160)
Namespace: molecular_function
Definition: Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
Synonyms: 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming); 2,3-dihydroxy-acid hydro-lyase activity; 2,3-dihydroxyisovalerate dehydratase activity; acetohydroxyacid dehydratase activity; alpha,beta-dihydroxyacid dehydratase activity; alpha,beta-dihydroxyisovalerate dehydratase activity; DHAD; dihydroxy acid dehydrase activity
obsolete dimethylnitrosamine demethylase activity (GO:0004162)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the removal of a methyl group from N-nitrosodimethylamine.
Synonyms: N-nitrosodimethylamine demethylase activity
Comment: This term was obsoleted because it represents a specific substrate.
ecdysone O-acyltransferase activity (GO:0004173)
Namespace: molecular_function
Definition: Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate.
Synonyms: acyl-CoA:ecdysone acyltransferase activity; fatty acyl-CoA:ecdysone acyltransferase activity; palmitoyl-CoA:ecdysone palmitoyltransferase activity
aminopeptidase activity (GO:0004177)
Namespace: molecular_function
Definition: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
obsolete lysine carboxypeptidase activity (GO:0004184)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.
Synonyms: anaphylatoxin inactivator activity; arginine carboxypeptidase activity; bradykinase activity; bradykinin-decomposing enzyme; carboxypeptidase N activity; CPase N; creatine kinase conversion factor; creatinine kinase convertase activity; hippuryllysine hydrolase activity; kininase I activity; kininase Ia; lysine (arginine) carboxypeptidase activity; lysine carboxypeptidase activity; lysine(arginine) carboxypeptidase activity; peptidyl-L-lysine(-L-arginine) hydrolase; plasma carboxypeptidase B
Comment: This term was made obsolete because it represents a gene product.
obsolete cathepsin D activity (GO:0004192)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.
Synonyms: cathepsin D activity
Comment: This term was made obsolete because it represents a gene product.
obsolete caspase-5 activity (GO:0004204)
Namespace: molecular_function
Definition: OBSOLETE. (Was not defined before being made obsolete).
Synonyms: caspase-5 activity
Comment: This term was made obsolete because it represents a gene product.
obsolete neprilysin activity (GO:0004245)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.
Synonyms: acute lymphoblastic leukemia antigen; CALLA; CALLA (common acute lymphoblastic leukemia-associated) antigens; CALLA antigen; CALLA glycoprotein; CALLA glycoproteins; CD10; common acute lymphoblastic leukemia antigen; common acute lymphoblastic leukemia-associated antigens; endopeptidase 24.11; endopeptidase-2 activity; enkephalinase activity; kidney-brush-border neutral endopeptidase; kidney-brush-border neutral peptidase; kidney-brush-border neutral proteinase activity; membrane metalloendopeptidase activity; neprilysin activity; neutral endopeptidase 24.11; neutral endopeptidase activity; neutral metallendopeptidase activity
Comment: This term was made obsolete because it represents a gene product.
obsolete subtilisin activity (GO:0004291)
Namespace: molecular_function
Definition: OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
Synonyms: alcalase 0.6L; alcalase 2.5L; alcalase activity; ALK-enzyme; bacillopeptidase A; bacillopeptidase B; bacillus subtilis alkaline proteinase activity; bacillus subtilis alkaline proteinase bioprase activity; bioprase AL 15; bioprase APL 30; colistinase activity; esperase activity; genenase I; kazusase activity; maxatase activity; opticlean; orientase 10B; protease S; protease VIII; protease XXVII; protin A 3L; savinase 16.0L; savinase 32.0 L EX; savinase 4.0T; savinase 8.0L; savinase activity; SP 266; subtilisin activity; subtilisin BL; subtilisin DY; subtilisin E; subtilisin GX; subtilisin J; subtilisin S41; subtilisin sendai; subtilopeptidase activity; superase activity; thermoase; thermoase PC 10
Comment: This term was made obsolete because it represents a gene product.
epoxide hydrolase activity (GO:0004301)
Namespace: molecular_function
Definition: Catalysis of the reaction: an epoxide + H2O = an ethanediol.
Synonyms: arene-oxide hydratase activity; aryl epoxide hydrase activity; cytosolic epoxide hydrolase activity; epoxide hydrase activity; epoxide hydratase activity; sEH; soluble epoxide hydrolase activity; trans-stilbene oxide hydrolase activity
ferredoxin-NADP+ reductase activity (GO:0004324)
Namespace: molecular_function
Definition: Catalysis of the reaction: 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH.
Synonyms: ferredoxin-NADP oxidoreductase activity; ferredoxin-NADP reductase activity; ferredoxin-NADP-oxidoreductase activity; ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity; ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity; ferredoxin-TPN reductase activity; ferredoxin:NADP+ oxidoreductase activity; NADP:ferredoxin oxidoreductase activity; NADPH:ferredoxin oxidoreductase activity; reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity; TPNH-ferredoxin reductase activity
glucose-6-phosphatase activity (GO:0004346)
Namespace: molecular_function
Definition: Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.
Synonyms: D-glucose-6-phosphate phosphohydrolase activity; glucose 6-phosphate phosphatase activity
glutamate-5-semialdehyde dehydrogenase activity (GO:0004350)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.
Synonyms: beta-glutamylphosphate reductase activity; gamma-glutamyl phosphate reductase activity; gamma-glutamylphosphate reductase activity; glutamate semialdehyde dehydrogenase activity; glutamate-gamma-semialdehyde dehydrogenase activity; glutamate-phosphate reductase activity; glutamyl-gamma-semialdehyde dehydrogenase activity; glutamylphosphate reductase activity; L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
glutaminase activity (GO:0004359)
Namespace: molecular_function
Definition: Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+.
Synonyms: glutaminase I; glutamine aminohydrolase activity; L-glutaminase activity; L-glutamine amidohydrolase activity
glycine dehydrogenase (decarboxylating) activity (GO:0004375)
Namespace: molecular_function
Definition: Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H+ = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2.
Synonyms: glycine cleavage system P-protein activity; glycine decarboxylase activity; glycine-cleavage complex; glycine-cleavage complex P-protein activity; glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating); glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating); P-protein; protein P1
glycylpeptide N-tetradecanoyltransferase activity (GO:0004379)
Namespace: molecular_function
Definition: Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.
Synonyms: myristoyl-CoA-protein N-myristoyltransferase activity; myristoyl-coenzyme A:protein N-myristoyl transferase activity; myristoylating enzymes; N-myristoyltransferase activity; peptide N-myristoyltransferase activity; peptide N-tetradecanoyltransferase activity; protein N-myristoyltransferase activity; tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity