Protein: Major prion protein (Mus musculus)
UniProt: P04925
Mutation: F197H|H186Y
PDB: 1AG2|1XYX
Experiment dataset: ProTherm
Method: Thermal
Measure: CD
pH: 5.5
Buffer: sodium acetate 50 mM
Tm: 60.4
dTm: -6.3
ddG: 1.17
dH: 53.3
Reversibility: no
State: 2.0
Reference: Pathological mutations H187R and E196K facilitate subdomain separation and prion protein conversion by destabilization of the native structure. — Had?i San|Ondra?ka Andrej|Jerala Roman|Hafner-Bratkovi? Iva (FASEB J;29;882-93, 2015)