Protein: POU domain, class 3, transcription factor 3 (Homo sapiens)
UniProt: P20264
Mutation: E446M
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.428467072534374
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)