Protein: DNA topoisomerase 3-alpha (Homo sapiens)
UniProt: Q13472
EC number: 5.6.2.1
Mutation: F845E
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.625894259833444
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)