Protein: Cyclin-dependent kinase inhibitor 2A (Homo sapiens)
UniProt: P42771
Mutation: W15D|L37S|L121R
PDB: 1A5E
Experiment dataset: ProTherm
Method: Urea
Measure: CD
pH: 8.5
Buffer: Tris 10 mM
Temperature: 20
dG: 4.77
ddG: -1.42
Cm: 2.8
m-value: 1.56
Reversibility: yes
Reference: Design and characterization of a hyperstable p16INK4a that restores Cdk4 binding activity when combined with oncogenic mutations. — Cammett Tobin J|Luo Li|Peng Zheng-yu (J Mol Biol;327;285-97, 2003)