Protein: POU domain, class 6, transcription factor 2 (Homo sapiens)
UniProt: P78424
Mutation: E649M
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.420059323617693
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)