Protein: Histone-lysine N-methyltransferase SETD2 (Homo sapiens)
UniProt: Q9BYW2
EC number: 2.1.1.359
Mutation: T2421Y
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.123296047509849
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)