Protein: Cystic fibrosis transmembrane conductance regulator (Homo sapiens)
UniProt: P13569
Mutation: F494N|Q637R
Experiment dataset: ProTherm
Method: Thermal
Measure: DSC
pH: 7.5
Buffer: HEPES 20 mM
Ion: NaCl 150 mM
Tm: 52.8
Reversibility: No
Reference: Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1. — Protasevich Irina|Yang Zhengrong|Wang Chi|Atwell Shane|Zhao Xun|Emtage Spencer|Wetmore Diana|Hunt John F|Brouillette Christie G (Protein Sci;19;1917-31, 2010)