Protein: E3 ubiquitin-protein ligase SMURF2 (Homo sapiens)
UniProt: Q9HAU4
EC number: 2.3.2.26
Mutation: E186Y
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.792065629042091
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)