Protein: Rho guanine nucleotide exchange factor TIAM1 (Homo sapiens)
UniProt: Q13009
Mutation: Y858K
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.951081234270063
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)