Protein: Histidine--tRNA ligase, cytoplasmic (Homo sapiens)
UniProt: P12081
EC number: 6.1.1.21
Mutation: K25F
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.450349092409835
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)