Protein: E3 ubiquitin-protein ligase HERC2 (Homo sapiens)
UniProt: O95714
EC number: 2.3.2.26
Mutation: V2586I
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.3117937143598
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)