Protein: E3 ubiquitin-protein ligase CBL (Homo sapiens)
UniProt: P22681
EC number: 2.3.2.27
Mutation: I874E
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.833481842122966
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)