Protein: POU domain, class 3, transcription factor 4 (Homo sapiens)
UniProt: P49335
Mutation: E333S
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.679241422905726
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)