Protein: Bromodomain-containing protein 2 (Homo sapiens)
UniProt: P25440
Mutation: E140K
PDB: 3ONI|4ALH
Experiment dataset: ProTherm
Method: Thermal
Measure: CD
pH: 7.5
Buffer: Tris-HCl 20mM
Ion: NaCl 0.2M
Tm: 44
dTm: -10.8
Reversibility: yes
State: 2.0
Reference: Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability. — Consalvi Valerio|Chiaraluce Roberta|Petrosino Maria|Lori Laura|Pasquo Alessandra|Lori Clorinda|Knapp Stefan|Tallant Cynthia (PLoS One;11;e0159180, 2016)