Protein: Spectrin alpha chain, non-erythrocytic 1 (Gallus gallus)
UniProt: P07751
Mutation: W1784F
PDB: 1SHG|1U4Q|1AJ3|1CUN
Experiment dataset: ProTherm
Method: Urea
Measure: Fluorescence
pH: 7.5
Buffer: Tris-HCl 10 mM
Temperature: 25
Ion: NaCl 0.14 M
dG: 3.66
ddG: 1.11
Cm: 1.91
m-value: 1.92
Reversibility: yes
Reference: Site-directed mutagenesis of either the highly conserved Trp-22 or the moderately conserved Trp-95 to a large, hydrophobic residue reduces the thermodynamic stability of a spectrin repeating unit. — Pantazatos D P|MacDonald R I (J Biol Chem;272;21052-9, 1997)