Protein: E3 ubiquitin-protein ligase NEDD4 (Homo sapiens)
UniProt: P46934
EC number: 2.3.2.26
Mutation: I859E
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.848973713887627
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)