Protein: NEDD4-like E3 ubiquitin-protein ligase WWP2 (Homo sapiens)
UniProt: O00308
EC number: 2.3.2.26
Mutation: L446S
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.600502604544697
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)