Protein: Antithrombin-III (Homo sapiens)
UniProt: P01008
Mutation: N167A|F109L
PDB: 1ANT
Experiment dataset: ProTherm
Method: Thermal
Measure: CD
pH: 7.4
Buffer: sodium phosphate 20 mM
Ion: NaCl 0.1 M
Tm: 46
dTm: -13
Reversibility: Unknown
Reference: Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability. — Whisstock James C|Bottomley Stephen P|Quinsey Noelene S|Fitton Hazel L|Coughlin Paul|Dafforn Timothy R|Carrell Robin W|Pike Robert N (Biochemistry;42;10169-73, 2003)