Protein: Disks large homolog 4 (Homo sapiens)
UniProt: P78352
Mutation: I189S
PDB: 3K82
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.733003277511662
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)