Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens)
UniProt: P16885
EC number: 3.1.4.11
Mutation: Y818M
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.416666936324022
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)