Protein: E3 ubiquitin-protein ligase Itchy homolog (Homo sapiens)
UniProt: Q96J02
EC number: 2.3.2.26
Mutation: E477D
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.559915317854478
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)