Protein: E3 ubiquitin-protein ligase Midline-1 (Homo sapiens)
UniProt: O15344
EC number: 2.3.2.27
Mutation: Y186W
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.0886672040276104
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)