Protein: E3 ubiquitin-protein ligase Mdm2 (Homo sapiens)
UniProt: Q00987
EC number: 2.3.2.27
Mutation: R321F
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.322788607044207
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)