Protein: Pyruvate dehydrogenase protein X component, mitochondrial (Homo sapiens)
UniProt: O00330
Mutation: L222M
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.0899062908938555
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)