Protein: Disks large homolog 4 (Homo sapiens)
UniProt: P78352
Mutation: I189E
PDB: 3K82
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.862024329141736
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)