Protein: E3 ubiquitin-protein ligase Midline-1 (Homo sapiens)
UniProt: O15344
EC number: 2.3.2.27
Mutation: M174L
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.0495568157479653
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)