Protein: Rho guanine nucleotide exchange factor 28 (Homo sapiens)
UniProt: Q8N1W1
Mutation: E677H
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.996334336140207
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)