Protein: Insulin receptor (Homo sapiens)
UniProt: P06213
EC number: 2.7.10.1
Mutation: W1202F
PDB: 1IR3
Experiment dataset: ProTherm
Method: GdnHCl
Measure: Fluorescence
pH: 7
Buffer: Tris-acetate 50 mM
Temperature: 24
dG: 9.5
ddG: -0.6
Cm: 2.8
m-value: 3.4
Reversibility: yes
Reference: Autophosphorylation dependent destabilization of the insulin receptor kinase domain: tryptophan-1175 reports changes in the catalytic cleft. — Bishop S M|Ross J B|Kohanski R A (Biochemistry;38;3079-89, 1999)