Protein: POU domain, class 3, transcription factor 4 (Homo sapiens)
UniProt: P49335
Mutation: E333I
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.611048743115326
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)