Protein: E3 ubiquitin-protein ligase NEDD4-like (Homo sapiens)
UniProt: Q96PU5
EC number: 2.3.2.26|2.3.2.36
Mutation: R223I
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.666536683920486
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)