Protein: E3 ubiquitin-protein ligase HUWE1 (Homo sapiens)
UniProt: Q7Z6Z7
EC number: 2.3.2.26
Mutation: L1325K
Experiment dataset: Domainome FITNESS
Domainome fitness: -0.623812035646939
Reference: Site-saturation mutagenesis of 500 human protein domains. — Beltran Antoni (Nature;637;885-894, 2025)