Protein: Fatty acid synthase
UniProt accession: A5YV76
Organism: Sus scrofa
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Laurasiatheria, Artiodactyla, Suina, Suidae, Sus
Gene names: FASN
Length: 2512 residues
Disorder content (fraction disordered): 0.1660031847133758
Curated region start positions: 1975, 1975, 1975, 2188, 2188, 2112
Curated region end positions: 1990, 1990, 1990, 2212, 2212, 2512
Curated region terms: disorder, disorder to order, small molecule binding, disorder, entropic chain, disorder
Domain/feature annotations: alpha/beta hydrolase, 3.40.47.10, Polyketide synthase dehydratase, ACP-like, Malonyl-Coenzyme A Acyl Carrier Protein, domain 2, Fatty acid synthase; domain 2, Vaccinia Virus protein VP39, 3.30.70.3290, Medium-chain alcohol dehydrogenases, catalytic domain, NAD(P)-binding Rossmann-like Domain, Beta-ketoacyl synthase, N-terminal domain, Phosphopantetheine attachment site, Acyl transferase domain, Thioesterase domain, Beta-ketoacyl synthase, C-terminal domain, Methyltransferase domain, KR domain, Zinc-binding dehydrogenase, Ketoacyl-synthetase C-terminal extension, Polyketide synthase dehydratase domain, Fatty acid synthase, pseudo-KR domain
Cross-references: PDB:2VZ8, PDB:2VZ9
Sequence:
MEEVVIAGMSGKLPESENLEEFWANLIGGVDMVTADDRRWKAGLYGLPRRMGKLKDLSRFDASFFGVHSKQANTMDPQLRMLLEVTYEAIVDGGINPASLRGTSTGVWVGVSSSDASEALSRDPETLVGYSMIGCQRAMMANRLSFFFDFKGPSITIDTACSSSLLALQSAYQAIRGGECSAAVVGGLNVLLKPNSSLQFMKLGMLSQDGTCRSFDAEGTGYCRAEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQGVTFPSGDVQEQLIRSLYAPAGPDPESLEYIEAHGTGTKVGDPQELNGIVNALCATRREPLLIGSTKSNMGHPEPASGVAALIKVLLSLEHGVWAPNLHYHTPNPEIPALQDGRLQVVDRPLPIRGGNVGINSFGFGGSNVHVILQPNSRPAPPPAQHAALPRLLQASGRTLEAVQTLLEQGLRHSRDLAFVGMLNEIAAVSPVAMPFRGYAVLGGEAGSQEVQQVPGSKRPVWFICSGMGAQWQGMGLSLMRLDRFRDSILRSDQALKPLGLRVSDLLLSTDEAVLDDIVSSFVSLTSIQIALIDLLTSLGLQPDGIIGHSLGEVACGYADGCLTQEEAVLSSYWRGYCIKEANVLPGAMAAVGLSWEECKQRCPPGIVPACHNSKDTVTISGPQAAMSEFLQQLKREDVFVKEVRTGGIAFHSYFMESIAPTLLRQLRKVILDPKPRSKRWLSTSIPEAQWQGSLARTFSAEYSVNNLVSPVLFQEALQHVPAHAVVVEIAPHALLQAVLKRSLESSCTIIPLMKKDHRDNLEFFLSNVGRLHLAGVSVNPNGLFPPVEFPAPRGTPLISPHXKWDHSQAWDVPSAADFPSGSSCSSVAVYKFDVSPESPDHYLVDHCIDGRVLFPGTGYLWLTWKTLARALSQNLEETPVVFEDVTLHQATILPKTGTVSLEVRLLEASHAFEVSDSNGSLIASGKVYQWESPDPKLFDTRAAVDPADSTAEFRLSQGDVYKDLRLRGYDYGPFFQLVLESDLEGNRGRLQWNDSWVSFLDAMLHMSILAPGQLGLYLPTRFTSIRIDPVTHRQKLYTLQDTTQAADVVVDRNLNTVVAGGALFLGAHSSVAPRRPQEHLKPILEKFCFTPHVESGCLAGNTALQEELQLCRGLAQALQTKVAQQGLKMVVPGLDGAQAPREAPQQSLPRLLAAACQLQLNGNLQLELGQVLAQERPLLCDDPLLSGLLDAPALKACVDTALENMASPKMKVVEVLAGDGQLYSRIPALLNTQPVMDLDYTATDRNPQALEAAQAKLEQLHVTQGQWDPANPAPGSLGKADLLVCNCALATLGDPAVAVGNMAATLKEGGFLLLHTLLAGHPLGEMVGFLTSPEQGGRHLLSQDQWESLFAGASLHLVALKRSFYGSVLFLCRQQTPQDSPVFLSVEDTSFRWVDSLKDILADASSRPVWLMAVGCSTSGVVGMVNCLRKEPGGHRIRCVLVSNLSSTSPAPEMHPSSSELQKVLQGDLVMNVYRDGAWGAFRHFPLEQDRPEKQTEHAFVNVLSRGDLSSIRWVCSPLHYALPASCQDRLCSVYYTSLNFRDVMLATGKLSPDSIPGKWLTRDCMLGMEFSGRDASGRRVMGMVPAEGLATSVLLLQHATWEVPSTWTLEEAASVPIVYTTAYYSLVVRGRMQPGESVLIHSGSGGVGQAAIAIALSRGCRVFTTVGSAEKRAYLQARFPQLDETCFANSRDTSFEQHVLRHTAGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHALGMAVFLKNVTFHGILLDSLFEEGGATWQEVSELLKAGIQEGVVQPLKCTVFPRTKVEAAFRYMAQGKHIGKVVIQVREEEQGPAPRGLPPIALTGLSKTFCPPHKSYVITGGLGGFGLQLAQWLRLRGAQKLVLTSRSGIRTGYQARQVREWRRQGVQVLVSTSNASSLDGARSLITEATQLGPVGGVFNLAMVLRDAVLENQTPEFFQDVSKPKYSGTANLDRVTREACPELDYFVIFSSVSCGRGNAGQANYGFANSAMERICEKRRHDGLPGLAVQWGAIGDVGVVLETMGTNDTVIGGTLPQRIASCLEVLDLFLSQPHPVLSSFVLAEKKAAAPRDGSSQKDLVKAVAHILGIRDVASINPDSTLVDLGLDSLMGVEVRQILEREHDLVLSMREVRQLSLRKLQELSSKTSTDADPATPTSHEDSPVRQQATLNLSTLLVNPEGPTLTRLNSVQSAERPLFLVHPIEGSITVFHGLAAKLSIPTYGLQCTGAAPLDSIQSLASYYIECIRQVQPEGPYRIAGYSYGACVAFEMCSQLQAQQSATPGNHSLFLFDGSHTFVLAYTQSVRAKMTPGCEAEAEAKAMYFFVQQFTDMEQGKVLEALIPLQGLEARVAATVDLITQSHAGLDRHALSFAARSFYQKLRAAENYWPQATYHGNVTLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESILSIIHSCLAEPRVSVREG