LiteFold/DisProt huggingface dataset:
Protein: DNA-binding protein
UniProt accession: P03265
Organism: Human adenovirus C serotype 5
Taxonomy: Viruses, Varidnaviria, Bamfordvirae, Preplasmiviricota, Tectiliviricetes, Rowavirales, Adenoviridae, Mastadenovirus
Gene names: DBP
Length: 529 residues
Disorder content (fraction disordered): 0.09829867674858224
Dataset labels: Viral proteins
Curated region start positions: 294, 454
Curated region end positions: 334, 464
Curated region terms: disorder, disorder
Domain/feature annotations: Adenovirus DNA-binding, N-terminal domain, Adenovirus DNA-binding, N-terminal domain, Adenovirus DNA-binding, C-terminal domain superfamily/Adenovirus DNA-binding, zinc binding domain, Viral DNA-binding protein, all alpha domain, Viral DNA-binding protein, zinc binding domain, Viral DNA-binding protein, zinc binding domain
Cross-references: PDB:1ADU, PDB:1ADV
Sequence:
MASREEEQRETTPERGRGAARRPPTMEDVSSPSPSPPPPRAPPKKRMRRRIESEDEEDSSQDALVPRTPSPRPSTSAADLAIAPKKKKKRPSPKPERPPSPEVIVDSEEEREDVALQMVGFSNPPVLIKHGKGGKRTVRRLNEDDPVARGMRTQEEEEEPSEAESEITVMNPLSVPIVSAWEKGMEAARALMDKYHVDNDLKANFKLLPDQVEALAAVCKTWLNEEHRGLQLTFTSKKTFVTMMGRFLQAYLQSFAEVTYKHHEPTGCALWLHRCAEIEGELKCLHGSIMINKEHVIEMDVTSENGQRALKEQSSKAKIVKNRWGRNVVQISNTDARCCVHDAACPANQFSGKSCGMFFSEGAKAQVAFKQIKAFMQALYPNAQTGHGHLLMPLRCECNSKPGHAPFLGRQLPKLTPFALSNAEDLDADLISDKSVLASVHHPALIVFQCCNPVYRNSRAQGGGPNCDFKISAPDLLNALVMVRSLWSENFTELPRMVVPEFKWSTKHQYRNVSLPVAHSDARQNPFDF
Protein: Cathelicidin antimicrobial peptide
UniProt accession: P49913
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CAMP, CAP18, FALL39, HSD26
Length: 170 residues
Disorder content (fraction disordered): 0.21764705882352944
Curated region start positions: 134, 134, 134, 150, 150
Curated region end positions: 170, 170, 170, 162, 162
Curated region terms: disorder, disorder to order, cytolysis, amyloid fibril formation, amyloid fibril formation
Domain/feature annotations: 3.10.450.10, Cathelicidin, LPS binding domain of CAP18 (C terminal)
Cross-references: PDB:6S6M
Sequence:
MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAIDGINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Protein: Antitermination protein N
UniProt accession: P03045
Organism: Escherichia phage lambda
Taxonomy: Viruses, Duplodnaviria, Heunggongvirae, Uroviricota, Caudoviricetes, Caudovirales, Siphoviridae, Lambdavirus
Gene names: N, lambdap49
Length: 107 residues
Disorder content (fraction disordered): 1
Dataset labels: Viral proteins, RNA-binding proteins
Curated region start positions: 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 34, 34, 1, 1, 1, 1
Curated region end positions: 107, 107, 107, 107, 107, 107, 107, 107, 107, 22, 47, 47, 22, 22, 107, 36
Curated region terms: disorder, disorder, disorder, single-stranded RNA binding, disorder, regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, RNA polymerase binding, disorder to order, protein binding, protein binding, RNA binding, regulation of transcription by RNA polymerase II, disorder, disorder to order
Domain/feature annotations: 36-mer N-terminal peptide of the N protein (N36)
Cross-references: PDB:6GOV
Sequence:
MDAQTRRRERRAEKQAQWKAANPLLVGVSAKPVNRPILSLNRKPKSRVESALNPIDLTVLAEYHKQIESNLQRIERKNQRTWYSKPGERGITCSGRQKIKGKSIPLI
Protein: Cytochrome c
UniProt accession: P00004
Organism: Equus caballus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Laurasiatheria, Perissodactyla, Equidae, Equus
Gene names: CYC, CYCS
Length: 105 residues
Disorder content (fraction disordered): 0.9904761904761904
Curated region start positions: 1, 1, 2, 2
Curated region end positions: 104, 104, 105, 105
Curated region terms: order to disorder, lipid binding, disorder, disorder
Domain/feature annotations: Cytochrome c-like domain, Cytochrome c
Sequence:
MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE
Protein: DNA-(apurinic or apyrimidinic site) lyase
UniProt accession: P27695
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: APE, APE1, APEX, APEX1, APX, HAP1, REF1
Length: 318 residues
Disorder content (fraction disordered): 0.13522012578616352
Dataset labels: Age-related disorders proteins
Curated region start positions: 1, 1, 32, 2
Curated region end positions: 42, 36, 43, 40
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Endonuclease/exonuclease/phosphatase, Endonuclease/Exonuclease/phosphatase family
Cross-references: PDB:1BIX, PDB:1E9N, PDB:4IEM
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
Protein: POU domain class 2-associating factor 1
UniProt accession: Q64693
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Obf-1, Pou2af1
Length: 256 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1, 1
Curated region end positions: 256, 256, 256, 65, 256
Curated region terms: disorder, disorder, disorder, disorder to order, protein binding
Domain/feature annotations: POU domain, class 2, associating factor 1
Sequence:
MLWQKSTAPEQAPAPPRPYQGVRVKEPVKELLRRKRGHTSVGAAGPPTAVVLPHQPLATYSTVGPSCLDMEVSASTVTEEGTLCAGWLSQPAPATLQPLAPWTPYTEYVSHEAVSCPYSTDMYVQPVCPSYTVVGPSSVLTYASPPLITNVTPRSTATPAVGPQLEGPEHQAPLTYFPWPQPLSTLPTSSLQYQPPAPTLSGPQFVQLPISIPEPVLQDMDDPRRAISSLTIDKLLLEEEESNTYELNHTLSVEGF
Protein: Transcription initiation factor IIA subunit 2
UniProt accession: P32774
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: TOA2, YKL058W
Length: 122 residues
Disorder content (fraction disordered): 0.12295081967213116
Curated region start positions: 89, 89, 90
Curated region end positions: 103, 103, 102
Curated region terms: disorder, flexible linker, disorder
Domain/feature annotations: Transcription factor IIA gamma subunit, alpha-helical domain, Transcription factor IIA (TFIIA), beta-barrel domain, Transcription initiation factor IIA, gamma subunit, helical domain, Transcription initiation factor IIA, gamma subunit
Cross-references: PDB:1NH2, PDB:1YTF
Sequence:
MAVPGYYELYRRSTIGNSLVDALDTLISDGRIEASLAMRVLETFDKVVAETLKDNTQSKLTVKGNLDTYGFCDDVWTFIVKNCQVTVEDSHRDASQNGSGDSQSVISVDKLRIVACNSKKSE
Protein: Sulfotransferase 1A3
UniProt accession: P0DMM9
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: STM, SULT1A3
Length: 295 residues
Disorder content (fraction disordered): 0.2033898305084746
Curated region start positions: 64, 64, 216
Curated region end positions: 77, 77, 261
Curated region terms: disorder, flexible linker, disorder
Domain/feature annotations: P-loop containing nucleotide triphosphate hydrolases, Sulfotransferase domain
Cross-references: PDB:1CJM
Sequence:
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
Protein: Cystic fibrosis transmembrane conductance regulator
UniProt accession: P13569
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ABCC7, CFTR
Length: 1480 residues
Disorder content (fraction disordered): 0.125
Curated region start positions: 708, 708, 654, 654, 708, 789, 762, 747, 747, 762, 789, 766, 766, 751, 698, 751, 764, 793
Curated region end positions: 831, 831, 838, 838, 831, 819, 801, 774, 774, 801, 819, 770, 770, 758, 702, 755, 774, 798
Curated region terms: disorder, phosphorylation display site, disorder, phosphorylation display site, disorder, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding, 14-3-3 protein binding
Domain/feature annotations: ABC transporter type 1, transmembrane domain, ABC transporter type 1, transmembrane domain, P-loop containing nucleotide triphosphate hydrolases, P-loop containing nucleotide triphosphate hydrolases, ABC transporter, ABC transporter, ABC transporter transmembrane region, ABC transporter transmembrane region, Cystic fibrosis TM conductance regulator (CFTR), regulator domain
Cross-references: BMRB:15336, BMRB:15340, ELM: LIG_14-3-3_CanoR_1, ELM:LIG_14-3-3_CanoR_1, PDB:5D2D, PDB:5D3E
Sequence:
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL
Protein: Choriogonadotropin subunit beta 3
UniProt accession: P0DN86
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CGB, CGB3, CGB5, CGB8
Length: 165 residues
Disorder content (fraction disordered): 0.20606060606060608
Curated region start positions: 132, 132, 133, 143
Curated region end positions: 165, 165, 165, 165
Curated region terms: disorder, disorder, disorder, glycosylation display site
Domain/feature annotations: Cystine-knot cytokines, Cystine-knot domain
Cross-references: PDB:1HCN, PDB:1HRP, PDB:1QFW
Sequence:
MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ
Protein: cAMP-dependent protein kinase inhibitor alpha
UniProt accession: P61926
Organism: Oryctolagus cuniculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Lagomorpha, Leporidae, Oryctolagus
Gene names: PKIA, PRKACN1
Length: 76 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1, 1, 1, 15, 38, 48, 48, 1, 15, 15, 1, 1, 1, 1, 1, 1
Curated region end positions: 76, 76, 76, 76, 76, 14, 24, 47, 75, 75, 14, 24, 24, 14, 14, 14, 76, 76, 76
Curated region terms: disorder, disorder, disorder, disorder, disorder, pre-molten globule to molten globule, disorder to molten globule, pre-molten globule to molten globule, protein binding, molecular adaptor activity, molecular adaptor activity, molecular adaptor activity, protein binding, protein binding, protein binding, pre-molten globule to molten globule, protein binding, molecular adaptor activity, molecular function inhibitor activity
Domain/feature annotations: cAMP-dependent protein kinase inhibitor
Cross-references: BMRB:50238, BMRB:50243
Sequence:
MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRSSTEQSGEAQGEAAKSES
Protein: Cyclin-dependent kinase inhibitor 1
UniProt accession: P38936
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CAP20, CDKN1, CDKN1A, CIP1, MDA6, PIC1, SDI1, WAF1
Length: 164 residues
Disorder content (fraction disordered): 1
Dataset labels: Cancer-related proteins, Autophagy-related proteins
Curated region start positions: 1, 1, 1, 1, 9, 9, 9, 1, 1, 1, 9, 9, 1, 1, 1, 1, 1, 1, 139, 139, 1, 1, 152, 1, 1, 143, 143, 139, 139, 143, 1, 143, 1, 1, 1, 1, 1
Curated region end positions: 164, 164, 164, 94, 84, 84, 84, 94, 94, 94, 84, 84, 164, 164, 164, 164, 164, 164, 160, 160, 164, 164, 158, 164, 164, 147, 147, 160, 143, 147, 164, 147, 164, 164, 164, 49, 164
Curated region terms: disorder, disorder, disorder, disorder, disorder to order, protein binding, disorder, disorder, molecular function inhibitor activity, protein binding, protein binding, molecular function inhibitor activity, molecular function inhibitor activity, protein binding, positive regulation of protein phosphorylation, negative regulation of protein phosphorylation, protein binding, ubiquitination display site, protein binding, protein sequestering activity, negative regulation of cell population proliferation, molecular function activator activity, protein binding, protein binding, protein binding, phosphorylation display site, phosphorylation display site, protein binding, import into nucleus, negative regulation of protein binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, phosphorylation display site, protein binding, PCNA-p21 complex, protein serine/threonine kinase binding, protein binding, protein binding
Domain/feature annotations: p27, Cyclin-dependent kinase inhibitor
Cross-references: DisProt:DP00287r060, DisProt:DP00287r063, ELM:LIG_PCNA_PIPBox_1, ELM:MOD_PKB_1, ELM:TRG_NLS_Bipartite_1, PDB:1AXC
Sequence:
MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
Protein: Cyclin-dependent kinase inhibitor 1C
UniProt accession: P49918
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CDKN1C, KIP2
Length: 316 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 27, 27, 27, 27, 1, 1
Curated region end positions: 316, 316, 316, 97, 97, 97, 97, 61, 316
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, molecular function inhibitor activity, protein binding, protein binding
Domain/feature annotations: p27, Cyclin-dependent kinase inhibitor
Cross-references: DisProt:DP00287r060, DisProt:DP00287r063
Sequence:
MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSAAPGVGSVEQTPRKRLR
Protein: Cyclin-dependent kinase inhibitor 1B
UniProt accession: P46527
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CDKN1B, KIP1, p27
Length: 198 residues
Disorder content (fraction disordered): 1
Dataset labels: Autophagy-related proteins, Cancer-related proteins
Curated region start positions: 38, 38, 105, 1, 55, 1, 97, 22, 22, 22, 22, 25, 25, 25, 25, 181, 181, 181, 185, 185, 1, 22, 1, 28, 66, 32, 8, 8, 32, 22, 38, 22, 22, 22, 86, 86, 91, 58, 58, 1, 1
Curated region end positions: 59, 59, 198, 198, 95, 50, 197, 97, 97, 97, 97, 93, 93, 93, 93, 185, 190, 190, 189, 190, 198, 105, 198, 37, 88, 45, 12, 12, 45, 105, 90, 97, 97, 97, 90, 90, 96, 105, 105, 60, 198
Curated region terms: flexible linker, disorder to order, disorder, disorder, protein binding, disorder, disorder, disorder, disorder, disorder to pre-molten globule, molecular function inhibitor activity, disorder to order, protein binding, molecular adaptor activity, cyclin-dependent protein kinase activating kinase regulator activity, protein binding, disorder to order, ubiquitin ligase activator activity, phosphorylation display site, ubiquitin protein ligase binding, localization, disorder, disorder, protein binding, protein binding, localization, nuclear export, phosphorylation display site, phosphorylation display site, disorder, disorder to order, disorder, disorder, protein binding, phosphorylation display site, phosphorylation display site, protein binding, disorder, disorder, protein binding, protein binding
Domain/feature annotations: p27, Cyclin-dependent kinase inhibitor
Cross-references: DisProt:DP00287r060, DisProt:DP00287r063, ELM:DEG_SCF_SKP2-CKS1_1, ELM:DOC_CYCLIN_RxL_1, ELM:MOD_CDK_SPxK_1, PDB:1JSU, PDB:2AST, PDB:5UQ3
Sequence:
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
Protein: DNA-binding protein RAP1
UniProt accession: P11938
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: GRF1, N1310, RAP1, TUF1, YNL216W
Length: 827 residues
Disorder content (fraction disordered): 0.28657799274486095
Curated region start positions: 1, 482, 627, 565, 627
Curated region end positions: 123, 512, 675, 598, 674
Curated region terms: disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: 1.10.10.2170, BRCT domain, 1.20.120.1480, Homeodomain-like, Homeodomain-like, Myb-like DNA-binding domain, Rap1, DNA-binding, TRF2-interacting telomeric protein/Rap1 - C terminal domain, BRCT domain
Cross-references: BMRB:17212, PDB:1IGN, PDB:2L42, PDB:4BJ6, PDB:4BJT
Sequence:
MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKANQNEENTGATAAETSEKVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGASVTEPTTDDTAADEKKEQVSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEVLDSKPRESKENVFIVSPYNHTNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVDSRLQEESHSNGVDNSNSNSDNKDSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARLQEQAQLLRQHVSSTASITSGGHNDLVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQTADEGNASFQAQRSMISRGALPSHNKASFTDEEDEFILDVVRKNPTRRTTHTLYDEISHYVPNHTGNSIRHRFRVYLSKRLEYVYEVDKFGKLVRDDDGNLIKTKVLPPSIKRKFSADEDYTLAIAVKKQFYRDLFQIDPDTGRSLITDEDTPTAIARRNMTMDPNHVPGSEPNFAAYRTQSRRGPIAREFFKHFAEEHAAHTENAWRDRFRKFLLAYGIDDYISYYEAEKAQNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRARNYSSQRNVQPTANAASANAAAAAAAAASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEKDLL
Protein: Elongation factor G
UniProt accession: P13551
Organism: Thermus thermophilus
Taxonomy: Bacteria, Deinococcus-Thermus, Deinococci, Thermales, Thermaceae, Thermus
Gene names: fus, fusA
Length: 691 residues
Disorder content (fraction disordered): 0.085383502170767
Curated region start positions: 40, 44, 42, 40, 416, 464
Curated region end positions: 64, 63, 60, 67, 434, 475
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: 3.30.230.10, Translation factors, P-loop containing nucleotide triphosphate hydrolases, Elongation Factor G (Translational Gtpase), domain 3, 3.30.70.240, Elongation factor Tu GTP binding domain, Elongation factor G C-terminus, Elongation factor Tu domain 2, Elongation factor G, domain IV, Elongation Factor G, domain III
Cross-references: PDB:1FNM, PDB:2BM0, PDB:2BM1, PDB:2BV3
Sequence:
MAVKVEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIHKIGEVHEGAATMDFMEQERERGITITAAVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGREDTFSGIIDVLRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLEGEEPTEEELVAAIRKGTIDLKITPVFLGSALKNKGVQLLLDAVVDYLPSPLDIPPIKGTTPEGEVVEIHPDPNGPLAALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMHANHREEVEELKAGDLGAVVGLKETITGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKADQEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKPQVAYRETITKPVDVEGKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFVNAIVGGVIPKEYIPAVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYHEVDSSEMAFKIAGSMAIKEAVQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARRGQILGMEPRGNAQVIRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQEVPKQVQEKLIKGQ
Protein: Estradiol 17-beta-dehydrogenase 1
UniProt accession: P14061
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: E17KSR, EDH17B1, EDH17B2, EDHB17, HSD17B1, SDR28C1
Length: 328 residues
Disorder content (fraction disordered): 0.13109756097560976
Curated region start positions: 286, 191, 191, 286
Curated region end positions: 328, 199, 199, 328
Curated region terms: disorder, flexible linker, small molecule binding, disorder
Domain/feature annotations: NAD(P)-binding Rossmann-like Domain, short chain dehydrogenase
Cross-references: PDB:1BHS, PDB:1FDU, PDB:1FDV, PDB:1FDW
Sequence:
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
Protein: Protein E7
UniProt accession: P03129
Organism: Human papillomavirus type 16
Taxonomy: Viruses, Monodnaviria, Shotokuvirae, Cossaviricota, Papovaviricetes, Zurhausenvirales, Papillomaviridae, Firstpapillomavirinae, Alphapapillomavirus
Gene names: E7
Length: 98 residues
Disorder content (fraction disordered): 0.5204081632653061
Dataset labels: Viral proteins
Curated region start positions: 1, 1, 1, 1, 1, 1, 1, 1, 21, 21, 21, 16, 16, 1, 1, 1, 1, 1, 1
Curated region end positions: 40, 40, 40, 40, 40, 40, 40, 46, 29, 29, 29, 40, 40, 40, 40, 40, 51, 51, 51
Curated region terms: disorder to order, disorder, disorder, disorder, disorder to order, disorder, disorder, disorder, viral process, protein binding, protein binding, protein binding, disorder, disorder, order, order, disorder, protein binding, protein binding
Domain/feature annotations: E7 protein, Early protein
Cross-references: BMRB:19269, BMRB:19442, PDB:4YOZ
Sequence:
MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP