LiteFold/DisProt huggingface dataset:
Protein: Solute carrier family 12 member 2
UniProt accession: A0A0G2KTI4
Organism: Danio rerio
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Actinopterygii, Neopterygii, Teleostei, Ostariophysi, Cypriniformes, Danionidae, Danioninae, Danio
Gene names: nkcc1, slc12a2
Length: 1136 residues
Disorder content (fraction disordered): 0.2420774647887324
Curated region start positions: 1, 856, 856
Curated region end positions: 205, 925, 925
Curated region terms: disorder, disorder, flexible linker
Domain/feature annotations: Amino acid permease, Solute carrier family 12, Amino acid permease N-terminal
Cross-references: EMDB:0471, EMDB:0473, EMDB:0475, PDB:6NPJ, PDB:6NPL
Sequence:
MSASPPISAGDYLSAPEPDALKPAGPTPSQSRFQVDLVTESAGDGETTVGFDSSPPEYVAEPPPDGLRDSVSGGEEAKGRFRVVNFAASSPDAAPAETAQNGDTVMSEGSLHSSTGGQQHHHYDTHTNTYYLRTFGHNTIDAVPKIDFYRQTAAPLGEKLIRPTLSELHDELDKEPFEDGFANGEELTPAEESAAKDVSESKGVVKFGWIKGVLVRCMLNIWGVMLFIRMTWIVGQAGIAYSCIIVIMATVVTTITGCSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVELLMDSGLLMIDQTNDIRVIGTITVILLLGISVAGMEWEAKAQIFLLVILITAIFNYFIGSFIAVDSKKKFGFFSYDAGILAENFGPDFRGQTFFSVFSIFFPAATGILAGANISGDLADPQMAIPKGTLLAILITGLVYVGVAISAGACIVRDATGIESNFTLISNCTDAACKYGYDFSSCRPTVEGEVSSCKFGLHNDFQVMSVVSGFSPLISAGIFSATLSSALASLVSAPKVFQALCKDNIYPGIAIFGKGYGKNNEPLRGYFLTFGIALAFILIAELNVIAPIISNFFLASYALINFSVFHASLANSPGWRPSFKYYNMWASLAGAILCCVVMFIINWWAALLTNVIVLSLYIYVSYKKPDVNWGSSTQALTYHQALTHSLQLCGVADHIKTFRPQCLVMTGAPNSRPAILHLVHAFTKNVGLMLCGHVRISSRRPNFKELNSDMLRYQRWLLNNNSKAFYTCVVAEDLRQGTQYMLQAAGLGRLRPNTLVIGFKNDWRTGDIKEVETYINLIHDAFDFQYGVVILRLREGLDISHIQGQDDSSGMKDVVVSVDISKDSDGDSSKPSSKATSVQNSPAVQKDEDDDGKAHTQPLLKKDKKSPTVPLNVADQRLLDASQQFQQKQGKGTVDVWWLFDDGGLTLLIPYLIANKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDITVLGDINTKPKSEGLTEFAEMIEPYKLREDDMEQEAAEKLKSEEPWRITDNELELYKAKGNRQIRLNELLKEHSSTANLIVMSMPLARKGAVSSALYMAWLDTLSKDLPPILLVRGNHQSVLTFYS
Protein: Serine/threonine-protein kinase B-raf
UniProt accession: P15056
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BRAF, BRAF1, RAFB1
Length: 766 residues
Disorder content (fraction disordered): 0.044386422976501305
Dataset labels: NDDs-related proteins, Cancer-related proteins, Condensates-related proteins
Curated region start positions: 600, 601, 597, 600, 601, 601, 432, 432
Curated region end positions: 611, 613, 613, 610, 614, 611, 447, 447
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: Phorbol esters/diacylglycerol binding domain (C1 domain), Raf-like Ras-binding domain, Protein tyrosine and serine/threonine kinase
Cross-references: PDB:1UWH, PDB:2FB8, PDB:3C4C, PDB:3II5, PDB:3OG7, PDB:3PPJ, PDB:3PPK, PDB:3PRF, PDB:3PRI
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Protein: Solute carrier family 12 member 5
UniProt accession: Q91V14
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Kcc2, Kiaa1176, Slc12a5
Length: 1138 residues
Disorder content (fraction disordered): 0.18189806678383127
Curated region start positions: 1, 952, 1027
Curated region end positions: 84, 1074, 1031
Curated region terms: disorder, disorder, phosphorylation display site
Domain/feature annotations: Amino acid permease, Amino acid permease, Solute carrier family 12, Solute carrier family 12, Solute carrier family 12
Cross-references: EMDB:30543, PDB:7D14
Sequence:
MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
Protein: 60S ribosomal protein L27
UniProt accession: Q9U4H7
Organism: Trypanosoma cruzi
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Trypanosoma, Schizotrypanum
Gene names: C3747_12g1558c, C3747_12g1559c, C4B63_9g2155c, C4B63_9g2158c
Length: 133 residues
Disorder content (fraction disordered): 0.15037593984962405
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 87
Curated region end positions: 106
Curated region terms: disorder
Domain/feature annotations: KOW motif, Ribosomal L27e protein family
Cross-references: PDB:5T5H
Sequence:
MKFLKPGKVVIVTSGRYAGKKAVIVQNTDSKSKERPYGHSLIAGMKKYPKKVVRGMSKRTIQRRSRVGVFLRVVNHKHFLPTRYNMDLSRELRGRINVSDASKKAKSKQLVRKLFQARYNAGSNRWFFQRLRF
Protein: Cyclin-dependent kinase 6
UniProt accession: Q00534
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CDK6, CDKN6
Length: 326 residues
Disorder content (fraction disordered): 0.1165644171779141
Dataset labels: NDDs-related proteins, Cancer-related proteins
Curated region start positions: 1, 46, 167, 45, 168, 1
Curated region end positions: 11, 55, 180, 56, 181, 10
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: Protein kinase domain
Cross-references: PDB:3NUP, PDB:3NUX, PDB:4AUA, PDB:4EZ5
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
Protein: Ceramide transfer protein
UniProt accession: Q9Y5P4
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CERT, CERT1, COL4A3BP, STARD11
Length: 624 residues
Disorder content (fraction disordered): 0.18269230769230768
Dataset labels: NDDs-related proteins
Curated region start positions: 344, 344, 187, 300
Curated region end positions: 361, 362, 218, 381
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: PH domain, START domain
Cross-references: PDB:2E3M, PDB:2E3N, PDB:2E3O, PDB:2E3P, PDB:2E3Q, PDB:2E3R, PDB:2E3S, PDB:2Z9Y, PDB:2Z9Z
Sequence:
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
Protein: ATP-dependent Clp protease proteolytic subunit, mitochondrial
UniProt accession: Q16740
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CLPP
Length: 277 residues
Disorder content (fraction disordered): 0.1588447653429603
Dataset labels: NDDs-related proteins
Curated region start positions: 57, 250
Curated region end positions: 72, 277
Curated region terms: disorder, disorder
Domain/feature annotations: Clp protease
Cross-references: PDB:6H23
Sequence:
MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
Protein: Conserved oligomeric Golgi complex subunit 4
UniProt accession: Q9H9E3
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: COG4
Length: 785 residues
Disorder content (fraction disordered): 0.015286624203821656
Dataset labels: NDDs-related proteins
Curated region start positions: 525
Curated region end positions: 536
Curated region terms: disorder
Domain/feature annotations: COG4 transport protein, middle alpha-helical bundle, Conserved oligomeric Golgi complex subunit 4, C-terminal, Conserved oligomeric Golgi complex subunit 4, N-terminal
Cross-references: PDB:3HR0
Sequence:
MADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL
Protein: D-ribitol-5-phosphate cytidylyltransferase
UniProt accession: A4D126
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CRPPA, ISPD
Length: 451 residues
Disorder content (fraction disordered): 0.03547671840354767
Dataset labels: NDDs-related proteins
Curated region start positions: 319
Curated region end positions: 334
Curated region terms: disorder
Domain/feature annotations: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, D-ribitol-5-phosphate cytidylyltransferase C-terminal domain
Cross-references: PDB:4CVH
Sequence:
MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEPGRHPQAVAAVLPAGGCGERMGVPTPKQFCPILERPLISYTLQALERVCWIKDIVVAVTGENMEVMKSIIQKYQHKRISLVEAGVTRHRSIFNGLKALAEDQINSKLSKPEVVIIHDAVRPFVEEGVLLKVVTAAKEHGAAGAIRPLVSTVVSPSADGCLDYSLERARHRASEMPQAFLFDVIYEAYQQCSDYDLEFGTECLQLALKYCCTKAKLVEGSPDLWKVTYKRDLYAAESIIKERISQEICVVMDTEEDNKHVGHLLEEVLKSELNHVKVTSEALGHAGRHLQQIILDQCYNFVCVNVTTSDFQETQKLLSMLEESSLCILYPVVVVSVHFLDFKLVPPSQKMENLMQIREFAKEVKERNILLYGLLISYPQDDQKLQESLRQGAIIIASLIKERNSGLIGQLLIA
Protein: Aspartate--tRNA ligase, cytoplasmic
UniProt accession: P14868
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DARS, DARS1, PIG40
Length: 501 residues
Disorder content (fraction disordered): 0.1277445109780439
Dataset labels: NDDs-related proteins
Curated region start positions: 224, 1, 273, 163, 163, 237, 239
Curated region end positions: 247, 20, 282, 172, 172, 241, 243
Curated region terms: disorder, disorder, disorder, disorder, flexible linker, phosphorylation display site, acetylation display site
Domain/feature annotations: tRNA synthetases class II (D, K and N), OB-fold nucleic acid binding domain
Cross-references: PDB:4J15
Sequence:
MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP
Protein: Aspartate--tRNA ligase, mitochondrial
UniProt accession: Q6PI48
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DARS2
Length: 645 residues
Disorder content (fraction disordered): 0.023255813953488372
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 631
Curated region end positions: 645
Curated region terms: disorder
Domain/feature annotations: tRNA synthetases class II (D, K and N), tRNA synthetases class II (D, K and N), OB-fold nucleic acid binding domain, GAD domain
Cross-references: PDB:4AH6
Sequence:
MYFPSWLSQLYRGLSRPIRRTTQPIWGSLYRSLLQSSQRRIPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSKAERAH
Protein: Deoxyhypusine synthase
UniProt accession: P49366
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DHPS, DS
Length: 369 residues
Disorder content (fraction disordered): 0.11924119241192412
Dataset labels: NDDs-related proteins
Curated region start positions: 76, 1, 1
Curated region end positions: 92, 27, 12
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Deoxyhypusine synthase
Cross-references: PDB:1DHS, PDB:6P4V, PDB:6PGR
Sequence:
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFMHEKNED
Protein: Delta-like protein 1
UniProt accession: O00548
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DLL1, UNQ146/PRO172
Length: 723 residues
Disorder content (fraction disordered): 0.1507607192254495
Dataset labels: NDDs-related proteins
Curated region start positions: 443
Curated region end positions: 551
Curated region terms: disorder
Domain/feature annotations: EGF-like domain, EGF-like domain, EGF-like domain, EGF-like domain, EGF-like domain, EGF-like domain, Delta serrate ligand, N terminus of Notch ligand C2-like domain, Delta-like/Jagged, EGF-like domain
Cross-references: PDB:4XBM
Sequence:
MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIATEV
Protein: Zinc finger protein ubi-d4
UniProt accession: Q92785
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BAF45D, DPF2, REQ, UBID4
Length: 391 residues
Disorder content (fraction disordered): 0.03836317135549872
Dataset labels: NDDs-related proteins
Curated region start positions: 235
Curated region end positions: 249
Curated region terms: disorder
Domain/feature annotations: PHD-finger, PHD-finger, DPF1-3, N-terminal
Cross-references: PDB:3IUF
Sequence:
MAAVVENVVKLLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLEALLRTDPLEKRGAPDPRVDDDSLGEFPVTNSRARKRILEPDDFLDDLDDEDYEEDTPKRRGKGKSKGKGVGSARKKLDASILEDRDKPYACDICGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCDDCDRGYHMYCLTPSMSEPPEGSWSCHLCLDLLKEKASIYQNQNSS
Protein: Bifunctional glutamate/proline--tRNA ligase
UniProt accession: P07814
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: EPRS, EPRS1, GLNS, PARS, PIG32, QARS, QPRS
Length: 1512 residues
Disorder content (fraction disordered): 0.018518518518518517
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 1003, 1464, 998, 1464, 1001
Curated region end positions: 1014, 1473, 1015, 1473, 1014
Curated region terms: disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: WHEP-TRS domain, WHEP-TRS domain, WHEP-TRS domain, tRNA synthetase class II core domain (G, H, P, S and T), tRNA synthetases class I (E and Q), catalytic domain, Anticodon binding domain, tRNA synthetases class I (E and Q), anti-codon binding domain, Prolyl-tRNA synthetase, C-terminal, tRNA synthetases class I (E and Q), anti-codon binding domain, Nuclear-export cofactor Arc1p
Cross-references: PDB:4HVC, PDB:5VAD, PDB:7OSY, PDB:7OSZ, PDB:7OT0, PDB:7OT1, PDB:7OT2, PDB:7OT3
Sequence:
MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTDVNSILRYLARVATTAGLYGSNLMEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNAAWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLENKDYKKTTKVTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPFKERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYKEKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRRRLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEIDCEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY
Protein: Squalene synthase
UniProt accession: P37268
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FDFT1
Length: 417 residues
Disorder content (fraction disordered): 0.03117505995203837
Dataset labels: NDDs-related proteins
Curated region start positions: 315
Curated region end positions: 327
Curated region terms: disorder
Domain/feature annotations: Squalene/phytoene synthase
Cross-references: PDB:1EZF
Sequence:
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
Protein: Alpha-(1,6)-fucosyltransferase
UniProt accession: Q9BYC5
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FUT8
Length: 575 residues
Disorder content (fraction disordered): 0.1165217391304348
Dataset labels: NDDs-related proteins
Curated region start positions: 68, 41
Curated region end positions: 107, 107
Curated region terms: disorder, disorder
Domain/feature annotations: Variant SH3 domain, Alpha-(1,6)-fucosyltransferase N- and catalytic domains
Cross-references: PDB:2DE0, PDB:6X5H, PDB:6X5R, PDB:6X5T, PDB:6X5U
Sequence:
MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGPAIGRVRVLEEQLVKAKEQIENYKKQTRNGLGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLGHHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWETVFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPRPPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPSLLKEAKTKYPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQIAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYKVREKIETVKYPTYPEAEK