LiteFold/DisProt huggingface dataset:
Protein: Synaptic functional regulator FMR1
UniProt accession: Q06787
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FMR1
Length: 632 residues
Disorder content (fraction disordered): 0.5237341772151899
Dataset labels: NDDs-related proteins, Condensates-related proteins, RNA-binding proteins
Curated region start positions: 281, 516, 444, 444, 445, 445, 445, 445, 527, 527, 529, 529, 281, 516, 516, 516
Curated region end positions: 422, 632, 632, 632, 632, 632, 632, 632, 541, 541, 542, 542, 422, 632, 632, 632
Curated region terms: disorder, poly(A) binding, intracellular non-membrane-bounded organelle, disorder, protein binding, protein binding, molecular condensate scaffold activity, molecular condensate scaffold activity, disorder to order, G-quadruplex RNA binding, disorder to order, G-quadruplex RNA binding, disorder, disorder, poly(G) binding, poly(U) RNA binding
Domain/feature annotations: K Homology domain, type 1, 2.30.30.140, 2.30.30.140, KH domain, KH domain, Agenet domain, Fragile X-related 1 protein core C terminal, Fragile X messenger ribonucleoprotein 1, C-terminal region 2, FMRP KH0 domain, Fragile X messenger ribonucleoprotein 1, Tudor domain
Cross-references: PDB:2LA5, PDB:5DE5, PDB:5DE8, PDB:5DEA
Sequence:
MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP
Protein: Heat shock factor protein
UniProt accession: P10961
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: HSF1, YGL073W
Length: 833 residues
Disorder content (fraction disordered): 0.28811524609843936
Dataset labels: Condensates-related proteins
Curated region start positions: 1, 260, 260, 1, 1
Curated region end positions: 167, 332, 332, 167, 167
Curated region terms: disorder, disorder, flexible linker, molecular function activator activity, disorder
Domain/feature annotations: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, HSF-type DNA-binding
Sequence:
MNNAANTGTTNESNVSDAPRIEPLPSLNDDDIEKILQPNDIFTTDRTDASTTSSTAIEDIINPSLDPQSAASPVPSSSFFHDSRKPSTSTHLVRRGTPLGIYQTNLYGHNSRENTNPNSTLLSSKLLAHPPVPYGQNPDLLQHAVYRAQPSSGTTNAQPRQTTRRYQSHKSRPAFVNKLWSMLNDDSNTKLIQWAEDGKSFIVTNREEFVHQILPKYFKHSNFASFVRQLNMYGWHKVQDVKSGSIQSSSDDKWQFENENFIRGREDLLEKIIRQKGSSNNHNSPSGNGNPANGSNIPLDNAAGSNNSNNNISSSNSFFNNGHLLQGKTLRLMNEANLGDKNDVTAILGELEQIKYNQIAISKDLLRINKDNELLWQENMMARERHRTQQQALEKMFRFLTSIVPHLDPKMIMDGLGDPKVNNEKLNSANNIGLNRDNTGTIDELKSNDSFINDDRNSFTNATTNARNNMSPNNDDNSIDTASTNTTNRKKNIDENIKNNNDIINDIIFNTNLANNLSNYNSNNNAGSPIRPYKQRYLLKNRANSSTSSENPSLTPFDIESNNDRKISEIPFDDEEEEETDFRPFTSRDPNNQTSENTFDPNRFTMLSDDDLKKDSHTNDNKHNESDLFWDNVHRNIDEQDARLQNLENMVHILSPGYPNKSFNNKTSSTNTNSNMESAVNVNSPGFNLQDYLTGESNSPNSVHSVPSNGSGSTPLPMPNDNDTEHASTSVNQGENGSGLTPFLTVDDHTLNDNNTSEGSTRVSPDIKFSATENTKVSDNLPSFNDHSYSTQADTAPENAKKRFVEEIPEPAIVEIQDPTEYNDHRLPKRAKK
Protein: Histone H1.4
UniProt accession: P15865
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: H1-4, H1f4
Length: 219 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1
Curated region end positions: 219, 219, 219
Curated region terms: disorder, disorder to order, DNA binding
Domain/feature annotations: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, linker histone H1 and H5 family
Sequence:
MSETAPAAPAAPAPAEKTPIKKKARKAAGGAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKKATGTATPKKSTKKTPKKAKKPAAAAGAKKAKSPKKAKATKAKKAPKSPAKARAVKPKAAKPKTSKPKAAKPKKTAAKKK
Protein: Hirudin variant-1
UniProt accession: P01050
Organism: Hirudo medicinalis
Taxonomy: Eukaryota, Metazoa, Spiralia, Lophotrochozoa, Annelida, Clitellata, Hirudinea, Hirudinida, Hirudiniformes, Hirudinidae, Hirudo
Length: 65 residues
Disorder content (fraction disordered): 0.24615384615384617
Curated region start positions: 50, 55, 55, 50, 50
Curated region end positions: 65, 64, 64, 65, 65
Curated region terms: disorder, protein binding, disorder to order, protein binding, disorder to order
Domain/feature annotations: Thrombin Inhibitor (Hirudin), subunit I, Hirudin
Cross-references: PDB:1AHT, PDB:1HRT, PDB:2HIR, PDB:4HIR, PDB:5HIR, PDB:6HIR
Sequence:
VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ
Protein: Parathyroid hormone-related protein
UniProt accession: P12272
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PTHLH, PTHRP
Length: 177 residues
Disorder content (fraction disordered): 0.5141242937853108
Curated region start positions: 37, 68
Curated region end positions: 50, 144
Curated region terms: disorder, disorder
Domain/feature annotations: Parathyroid hormone family
Cross-references: PDB:3FFD
Sequence:
MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH
Protein: 50S ribosomal protein L27
UniProt accession: P0A7L8
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW3152, b3185, rpmA
Length: 85 residues
Disorder content (fraction disordered): 1
Dataset labels: RNA-binding proteins
Curated region start positions: 1, 1
Curated region end positions: 85, 85
Curated region terms: disorder, disorder
Domain/feature annotations: 2.40.50.100, Ribosomal L27 protein
Sequence:
MAHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE
Protein: Heat shock protein beta-1
UniProt accession: P14602
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Hsp25, Hsp27, Hspb1
Length: 209 residues
Disorder content (fraction disordered): 0.0861244019138756
Curated region start positions: 192, 199, 199, 192
Curated region end positions: 209, 204, 204, 209
Curated region terms: disorder, protein stabilization, protein folding chaperone, protein folding chaperone
Domain/feature annotations: 2.60.40.790, Hsp20/alpha crystallin family
Sequence:
MTERRVPFSLLRSPSWEPFRDWYPAHSRLFDQAFGVPRLPDEWSQWFSAAGWPGYVRPLPAATAEGPAAVTLAAPAFSRALNRQLSSGVSEIRQTADRWRVSLDVNHFAPEELTVKTKEGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSSLSPEGTLTVEAPLPKAVTQSAEITIPVTFEARAQIGGPEAGKSEQSGAK
Protein: Histone RNA hairpin-binding protein
UniProt accession: Q9VAN6
Organism: Drosophila melanogaster
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Arthropoda, Hexapoda, Insecta, Pterygota, Neoptera, Endopterygota, Diptera, Brachycera, Muscomorpha, Ephydroidea, Drosophilidae, Drosophila, Sophophora
Gene names: CG11886, Slbp
Length: 276 residues
Disorder content (fraction disordered): 0.7028985507246377
Dataset labels: RNA-binding proteins
Curated region start positions: 258, 108, 1, 109, 1, 17
Curated region end positions: 276, 172, 16, 175, 175, 108
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: Histone RNA hairpin-binding protein RNA-binding domain, Histone RNA hairpin-binding protein RNA-binding domain
Cross-references: PDB:4TUX
Sequence:
MLCEDQHMSVENTPQKGSGSLNSSASSISIDVKPTMQSWAQEVRAEFGHSDEASSSLNSSAASCGSLAKKETADGNLESKDGEGREMAFEFLDGVNEVKFERLVKEEKLKTPYKRRHSFTPPSNENSRSNSPNSSNSSANGDAAAPKGGNNPHSRNSKKSGNFRAHKEEKRVRHNSYTSSTSSSSSYTEADPAILSRRQKQIDYGKNTAAYERYVEMVPKDERTRDHPRTPNKYGKYSRRAFDGLVKIWRKSLHIYDPPTQARDTAKDSNSDSDSD
Protein: Gag polyprotein
UniProt accession: P03347
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BH10)
Taxonomy: Viruses, Riboviria, Pararnavirae, Artverviricota, Revtraviricetes, Ortervirales, Retroviridae, Orthoretrovirinae, Lentivirus
Gene names: gag
Length: 512 residues
Disorder content (fraction disordered): 0.06640625
Dataset labels: Viral proteins, RNA-binding proteins
Curated region start positions: 378, 428
Curated region end positions: 389, 449
Curated region terms: disorder, disorder
Domain/feature annotations: Human Immunodeficiency Virus Type 1 Capsid Protein, Immunodeficiency lentiviruses, gag gene matrix protein p17, 1.10.1200.30, Zinc finger, CCHC-type, Single helix bin, Zinc knuckle, Zinc knuckle, gag gene protein p17 (matrix protein), gag protein p24 N-terminal domain, Gag protein p6, Gag protein p24 C-terminal domain
Sequence:
MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSSQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNTATIMMQRGNFRNQRKMVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSYKGRPGNFLQSRPEPTAPPFLQSRPEPTAPPEESFRSGVETTTPPQKQEPIDKELYPLTSLRSLFGNDPSSQ
Protein: Neurofilament light polypeptide
UniProt accession: P02547
Organism: Sus scrofa
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Laurasiatheria, Artiodactyla, Suina, Suidae, Sus
Gene names: NEFL
Length: 549 residues
Disorder content (fraction disordered): 0.1930783242258652
Curated region start positions: 444, 444
Curated region end positions: 549, 549
Curated region terms: disorder, flexible C-terminal tail
Domain/feature annotations: Vasodilator-stimulated phosphoprotein, 1.20.5.170, Single helix bin, Intermediate filament protein, Intermediate filament head (DNA binding) region
Sequence:
MSSFYSEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAQLLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQAQIQYAQISVEMDVSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSLTTGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEGKEKEEAEAEAEAEEEGAQEEEEAAEKEESEEAKEEEGGEGEQGEETKEAEEEEKKDEGAGEEQATKKKD
Protein: DNA repair protein XRCC4
UniProt accession: Q13426
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: XRCC4
Length: 336 residues
Disorder content (fraction disordered): 0.4017857142857143
Dataset labels: NDDs-related proteins
Curated region start positions: 204, 202, 262, 202
Curated region end positions: 265, 336, 288, 336
Curated region terms: disorder, disorder, DNA binding, disorder
Domain/feature annotations: 1.20.5.370, DNA double-strand break repair and VJ recombination XRCC4, N-terminal, XRCC4 N-terminal domain, XRCC4 coiled-coil, XRCC4 C-terminal region
Cross-references: BMRB:52398, PDB:1FU1, PDB:7NFC, PDB:7NFE
Sequence:
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAMEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPAEVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSRPDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Protein: GTPase HRas
UniProt accession: P01112
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HRAS, HRAS1
Length: 189 residues
Disorder content (fraction disordered): 0.1058201058201058
Dataset labels: Cancer-related proteins, NDDs-related proteins
Curated region start positions: 170
Curated region end positions: 189
Curated region terms: disorder
Domain/feature annotations: P-loop containing nucleotide triphosphate hydrolases, Ras family
Cross-references: PDB:4Q21
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
Protein: Syntaxin-1A
UniProt accession: P32851
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Sap, Stx1a
Length: 288 residues
Disorder content (fraction disordered): 0.059027777777777776
Curated region start positions: 10, 10
Curated region end positions: 26, 26
Curated region terms: disorder, disorder
Domain/feature annotations: 1.20.5.110, 1.20.58.70, Syntaxin, SNARE domain
Cross-references: PDB:3C98, PDB:4JEU
Sequence:
MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIIIASTIGGIFG
Protein: Cell invasion protein SipA
UniProt accession: P0CL52
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Salmonella
Gene names: STM2882, sipA, sspA
Length: 685 residues
Disorder content (fraction disordered): 0.18832116788321168
Dataset labels: Bacterial virulence-related proteins
Curated region start positions: 497, 659, 446, 659, 426, 659, 426, 659, 229
Curated region end positions: 513, 670, 513, 685, 513, 685, 513, 685, 242
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: SipA N-terminal domain-like, Salmonella invasion protein A, C-terminal actin-binding domain, SipA N-terminal domain, Salmonella Invasion protein A, C-terminal actin binding domain
Cross-references: PDB:1Q5Z, PDB:2FM9
Sequence:
MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNSQRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHATAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFDARETFLGVIRKALEPDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETDYVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR
Protein: Cadherin-1
UniProt accession: P09803
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Cdh1
Length: 884 residues
Disorder content (fraction disordered): 0.16855203619909503
Curated region start positions: 812, 812, 812, 812, 812, 812, 812, 812, 812, 812, 812, 812, 732, 778, 784, 855, 778, 736, 736, 736, 736, 812, 812, 812, 812, 736
Curated region end positions: 884, 884, 884, 884, 884, 884, 884, 884, 884, 884, 884, 884, 884, 884, 852, 881, 884, 884, 884, 884, 884, 884, 884, 884, 884, 884
Curated region terms: molecular adaptor activity, disorder to order, protein binding, molecular adaptor activity, disorder to order, protein binding, molecular adaptor activity, disorder to order, protein binding, molecular adaptor activity, disorder to order, protein binding, protein binding, protein binding, disorder to order, disorder to order, phosphorylation display site, disorder, disorder, disorder, disorder, molecular function regulator, molecular function regulator, molecular function regulator, molecular function regulator, protein binding
Domain/feature annotations: TCF3-CBD (Catenin binding domain), Cadherins, Cadherins, Cadherins, Cadherins, Cadherins, Cadherins, Cadherin domain, Cadherin domain, Cadherin domain, Cadherin domain, Cadherin domain, Cadherin, Y-type LIR-motif, Cadherin prodomain like
Cross-references: PDB:3IFQ
Sequence:
MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD
Protein: Cell division protein ZipA
UniProt accession: P77173
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW2404, b2412, zipA
Length: 328 residues
Disorder content (fraction disordered): 0.47865853658536583
Curated region start positions: 29, 29
Curated region end positions: 185, 185
Curated region terms: disorder, flexible linker
Domain/feature annotations: ZipA, C-terminal FtsZ-binding domain, ZipA, C-terminal FtsZ-binding domain
Sequence:
MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPVQQPPEAQVPPQHAPHPAQPVQQPAYQPQPEQPLQQPVSPQVAPAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA
Protein: Stannin
UniProt accession: O75324
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SNN
Length: 88 residues
Disorder content (fraction disordered): 0.3068181818181818
Curated region start positions: 34, 34
Curated region end positions: 60, 60
Curated region terms: disorder, flexible linker
Domain/feature annotations: membrane protein stannin, Stannin transmembrane, Stannin unstructured linker, Stannin cytoplasmic
Cross-references: PDB:1ZZA
Sequence:
MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTPNGPEVHG
Protein: Protein GIR2
UniProt accession: Q03768
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: DFRP2, GIR2, YD8358.08, YDR152W
Length: 265 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 166, 265, 166, 265
Curated region terms: disorder, disorder, disorder, pre-molten globule
Domain/feature annotations: RWD domain
Sequence:
MDYKEEQKQELEVLESIYPDELRIINDEYPKIKFEVAIKLELDTGDSTSVLTKEHTIIAEFKLPENYPDEPCLISLEAQEVALNDNEEDNEEDEDEVEYDDHGNKVLKKFENLPDLISFKGYLPELTVQLESQIETDMLLGMQMCFALISSIKERCEQWYSEQLNKLEKQYELEAQEREKKEQAKFHGTKVTRESYLEWRSKFRQELKLDERDQVRRMKAHHGKLTGKQMFEQGVVGTGDEYMEEDDASVDDVAKGLAKTEIANQ
Protein: 60S acidic ribosomal protein P1-alpha
UniProt accession: P05318
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: L12EIIA, RPA1, RPLA1, RPP1A, YDL081C
Length: 106 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 106, 106, 106, 106
Curated region terms: disorder, disorder, protein binding, protein binding
Domain/feature annotations: 1.10.10.1410, 60s Acidic ribosomal protein
Sequence:
MSTESALSYAALILADSEIEISSEKLLTLTNAANVPVENIWADIFAKALDGQNLKDLLVNFSAGAAAPAGVAGGVAGGEAGEAEAEKEEEEAKEESDDDMGFGLFD
Protein: Troponin I, cardiac muscle
UniProt accession: P19429
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TNNC1, TNNI3
Length: 210 residues
Disorder content (fraction disordered): 0.45714285714285713
Curated region start positions: 192, 137, 137, 1, 167, 167
Curated region end positions: 210, 148, 148, 40, 210, 210
Curated region terms: disorder, disorder, flexible linker, disorder, disorder, order to disorder
Domain/feature annotations: 1.20.5.350, Troponin, Troponin I residues 1-32
Cross-references: PDB:1J1D, PDB:1J1E, PDB:7UTI, PDB:7UTL
Sequence:
MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSGMEGRKKKFES
Protein: Pyridoxine-5'-phosphate oxidase
UniProt accession: Q9NVS9
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PNPO
Length: 261 residues
Disorder content (fraction disordered): 0.1839080459770115
Dataset labels: NDDs-related proteins
Curated region start positions: 1
Curated region end positions: 48
Curated region terms: disorder
Domain/feature annotations: Electron Transport, Fmn-binding Protein; Chain A, Pyridoxamine 5'-phosphate oxidase, Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
Cross-references: PDB:1NRG
Sequence:
MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAFEETHLTSLDPVKQFAAWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKELDSNPFASLVFYWEPLNRQVRVEGPVKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPDREYLRKKNEELEQLYQDQEVPKPKSWGGYVLYPQVMEFWQGQTNRLHDRIVFRRGLPTGDSPLGPMTHRGEEDWLYERLAP
Protein: Tubulin beta-2 chain
UniProt accession: P32882
Organism: Gallus gallus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Archelosauria, Archosauria, Dinosauria, Saurischia, Theropoda, Coelurosauria, Aves, Neognathae, Galloanserae, Galliformes, Phasianidae, Phasianinae, Gallus
Length: 445 residues
Disorder content (fraction disordered): 0.03146067415730337
Curated region start positions: 432
Curated region end positions: 445
Curated region terms: disorder
Domain/feature annotations: Helix hairpin bin, Tubulin/FtsZ, GTPase domain, Tubulin/FtsZ, C-terminal domain, Tubulin/FtsZ family, GTPase domain, Tubulin C-terminal domain
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA