LiteFold/DisProt huggingface dataset:
Protein: Vitronectin
UniProt accession: P04004
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: VTN
Length: 478 residues
Disorder content (fraction disordered): 0.2719665271966527
Dataset labels: Extracellular matrix proteins
Curated region start positions: 48, 1, 1, 1, 1, 1, 59, 22, 22, 22
Curated region end positions: 130, 130, 130, 130, 130, 71, 70, 58, 58, 58
Curated region terms: disorder, disorder, molecular adaptor activity, protein binding, disorder to order, protein binding, disorder, protein binding, disorder to order, molecular function regulator
Domain/feature annotations: Hemopexin, Hemopexin, Hemopexin, Hemopexin, Somatomedin B domain
Cross-references: PDB:1OC0
Sequence:
MAPLRPLLILALLAWVALADQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQVTRGDVFTMPEDEYTVYDDGEEKNNATVHEQVGGPSLTSDLQAQSKGNPEQTPVLKPEEEAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKGKQYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQRDSWEDIFELLFWGRTSAGTRQPQFISRDWHGVPGQVDAAMAGRIYISGMAPRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQNSRRPSRATWLSLFSSEESNLGANNYDDYRMDWLVPATCEPIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAPGHL
Protein: Retinoic acid receptor RXR-gamma
UniProt accession: P48443
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NR2B3, RXRG
Length: 463 residues
Disorder content (fraction disordered): 0.27213822894168466
Dataset labels: Condensates-related proteins
Curated region start positions: 2, 2, 2, 2, 2, 2
Curated region end positions: 127, 127, 127, 127, 127, 127
Curated region terms: disorder, disorder, pre-molten globule, pre-molten globule, disorder, molecular condensate scaffold activity
Domain/feature annotations: Ligand-binding domain of nuclear hormone receptor, Double treble clef zinc finger, C4 type, Nuclear/hormone receptor activator site AF-1
Sequence:
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
Protein: Caprin-1
UniProt accession: Q14444
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CAPRIN1, GPIAP1, GPIP137, M11S1, RNG105
Length: 709 residues
Disorder content (fraction disordered): 0.14527503526093088
Dataset labels: NDDs-related proteins, Condensates-related proteins
Curated region start positions: 607, 607, 607, 607
Curated region end positions: 709, 709, 709, 709
Curated region terms: disorder, molecular condensate scaffold activity, protein binding, protein binding
Domain/feature annotations: Cytoplasmic activation/proliferation-associated protein-1 C term, Caprin-1 dimerization domain
Sequence:
MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQTVVGTYHGSPDQSHQVTGNHQQPPQQNTGFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSNTPNSGYTQSQFSAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN
Protein: Transcription factor PU.1
UniProt accession: P17947
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SPI1
Length: 270 residues
Disorder content (fraction disordered): 0.6703703703703704
Dataset labels: Age-related disorders proteins
Curated region start positions: 118, 1, 258, 118
Curated region end positions: 165, 168, 270, 165
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Ets-domain
Sequence:
MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHSEFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRHPPH
Protein: Ankyrin repeat domain-containing protein EMB506, chloroplastic
UniProt accession: Q9SQK3
Organism: Arabidopsis thaliana
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, rosids, malvids, Brassicales, Brassicaceae, Camelineae, Arabidopsis
Gene names: At5g40160, EMB506, MSN9.60
Length: 315 residues
Disorder content (fraction disordered): 0.23174603174603176
Dataset labels: Condensates-related proteins
Curated region start positions: 40, 40, 40, 40
Curated region end positions: 112, 112, 112, 112
Curated region terms: disorder, protein binding, protein binding, molecular condensate scaffold activity
Domain/feature annotations: Ankyrin repeats (3 copies)
Sequence:
MVSSVLSIPPQTCLLPRLPISDSVNCKSKIVYCLSTSVRGSSVKRQSTARTRSFTETNRRTPSVQSKHEFWEDPDDGSDSENEYEGEEEDGIGNDLDNESDWEDDSRVQKLTTTDNYEEELAKEVEQLLEPEERVILQQNEKPNLKMISTKSWKPLQTLALSMQIQLMDNLIENGLDIDDVDKDNQTALHKAIIGKKEAVISHLLRKGANPHLQDRDGAAPIHYAVQVGALQTVKLLFKYNVDVNVADNEGWTPLHIAVQSRNRDITKILLTNGADKTRRTKDGKLALDLALCFGRDFKSYDLVKLLKIMPTGDI
Protein: Ankyrin repeat domain-containing protein, chloroplastic
UniProt accession: Q05753
Organism: Arabidopsis thaliana
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, rosids, malvids, Brassicales, Brassicaceae, Camelineae, Arabidopsis
Gene names: AKR, AKRP, At5g66055, EMB2036, K2A18.13
Length: 435 residues
Disorder content (fraction disordered): 0.4482758620689655
Dataset labels: Condensates-related proteins
Curated region start positions: 37, 37, 37, 37
Curated region end positions: 231, 231, 231, 231
Curated region terms: disorder, protein binding, protein binding, molecular condensate scaffold activity
Domain/feature annotations: Ankyrin repeats (3 copies), Ankyrin repeats (many copies)
Sequence:
MQSLSTPHTISLLLPRTSPSRLSPSLHSLAFPTRLRSLSYSSQTSILPDAGDDFIVGDCLVYEDGVFEDPYLDKEVTQVAKQERKKNRRGGAKRLDESEIEPENLVPEEWRDIQAEVNLTKKDKRKIAQEMEFGVRVEKKRQGLIPLRKVDLNDFLTYKEAKLAQLRPVILDKPGNFSDDSGASSDGETAVSSPSERVAPKNPRWAVYGKGFDHVAKFFNSDKYDPSDKKSDGPRKLLSKEEKFMLNSRNPDLAVATSKKWLPLHTLAACGEFYLVDSLLKHNLDINATDVGGLTVLHRAIIGKKQAITNYLLRESANPFVLDDEGATLMHYAVQTASAPTIKLLLLYNADINAQDRDGWTPLHVAVQARRSDIVKLLLIKGADIEVKNKDGLTPLGLCLYLGREIRTYEVMKLLKEFPLSRHKKRLVTTDEDIE
Protein: Splicing factor U2AF 65 kDa subunit
UniProt accession: P26368
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: U2AF2, U2AF65
Length: 475 residues
Disorder content (fraction disordered): 0.05894736842105263
Dataset labels: Condensates-related proteins
Curated region start positions: 231, 250, 231, 231, 231
Curated region end positions: 258, 259, 235, 258, 258
Curated region terms: disorder, protein binding, protein binding, molecular function inhibitor activity, flexible linker
Domain/feature annotations: RNA recognition motif, RNA recognition motif, RNA recognition motif
Cross-references: PDB:6TR0
Sequence:
MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
Protein: Glycoprotein hormones alpha chain
UniProt accession: P01215
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CGA
Length: 116 residues
Disorder content (fraction disordered): 0.3017241379310345
Curated region start positions: 33, 1
Curated region end positions: 57, 10
Curated region terms: disorder, disorder
Domain/feature annotations: Glycoprotein hormone
Cross-references: PDB:1DZ7
Sequence:
MDYYRKYAAIFLVTLSVFLHVLHSAPDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
Protein: Hypoxanthine-guanine-xanthine phosphoribosyltransferase
UniProt accession: Q26997
Organism: Toxoplasma gondii
Taxonomy: Eukaryota, Sar, Alveolata, Apicomplexa, Conoidasida, Coccidia, Eucoccidiorida, Eimeriorina, Sarcocystidae, Toxoplasma
Gene names: HPRT
Length: 230 residues
Disorder content (fraction disordered): 0.04782608695652174
Curated region start positions: 116
Curated region end positions: 126
Curated region terms: disorder
Domain/feature annotations: Phosphoribosyl transferase domain
Cross-references: PDB:1DBR
Sequence:
MASKPIEDYGKGKGRIEPMYIPDNTFYNADDFLVPPHCKPYIDKILLPGGLVKDRVEKLAYDIHRTYFGEELHIICILKGSRGFFNLLIDYLATIQKYSGRESSVPPFFEHYVRLKSYQNDNSTGQLTVLSDDLSIFRDKHVLIVEDIVDTGFTLTEFGERLKAVGPKSMRIATLVEKRTDRSNSLKGDFVGFSIEDVWIVGCCYDFNEMFRDFDHVAVLSDAARKKFEK
Protein: AcrIIA5
UniProt accession: A0A220GHA5
Organism: Streptococcus phage D4276
Taxonomy: Viruses, Duplodnaviria, Heunggongvirae, Uroviricota, Caudoviricetes, Caudovirales, Siphoviridae, Moineauvirus, unclassified Moineauvirus
Gene names: D4276_028
Length: 140 residues
Disorder content (fraction disordered): 0.15714285714285714
Dataset labels: Viral proteins, RNA-binding proteins
Curated region start positions: 1, 1, 1
Curated region end positions: 22, 22, 22
Curated region terms: disorder, molecular function inhibitor activity, RNA binding
Cross-references: BMRB:50185, PDB:6LKF
Sequence:
MAYGKSRYNSYRKRSFNRSNKQRREYAQEMDRLEKAFENLDGWYLSSMKDSAYKDFGKYEIRLSNHSADNKYHDLENGRLIVNIKASKLNFVDIIENKLDKIIEKIDKLDLDKYRFINATNLEHDIKCYYKGFKTKKEVI
Protein: MAPK phosphothreonine lyase
UniProt accession: P0A2N1
Organism: Salmonella enteritidis
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Salmonella
Gene names: mkaD, spvC, vsdD
Length: 241 residues
Disorder content (fraction disordered): 0.1078838174273859
Dataset labels: Bacterial virulence-related proteins
Curated region start positions: 1
Curated region end positions: 26
Curated region terms: disorder
Domain/feature annotations: Salmonella virulence-associated 28kDa protein
Cross-references: PDB:2P1W, PDB:2Q8Y
Sequence:
MPINRPNLNLNIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE
Protein: Epsin-1
UniProt accession: Q9Y6I3
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: EPN1
Length: 576 residues
Disorder content (fraction disordered): 0.03125
Curated region start positions: 1, 1, 1, 1, 1
Curated region end positions: 18, 18, 18, 18, 18
Curated region terms: disorder, small molecule binding, disorder to order, molecular sequestering activity, molecular sequestering activity
Domain/feature annotations: ENTH domain
Sequence:
MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
Protein: Peptidylarginine deiminase
UniProt accession: Q9RQJ2
Organism: Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomy: Bacteria, Bacteroidetes, Bacteroidia, Bacteroidales, Porphyromonadaceae, Porphyromonas
Gene names: PG_1424
Length: 556 residues
Disorder content (fraction disordered): 0.03776978417266187
Curated region start positions: 464, 464
Curated region end positions: 484, 484
Curated region terms: disorder, flexible linker
Domain/feature annotations: Porphyromonas-type peptidyl-arginine deiminase
Cross-references: PDB:5AK7, PDB:5AK8
Sequence:
MKKLLQAKALILALGLFQLPAIAQTQMQADRTNGQFATEEMQRAFQETNPPAGPVRAIAEYERSAAVLVRYPFGIPMELIKELAKNDKVITIVASESQKNTVITQYTQSGVNLSNCDFIIAKTDSYWTRDYTGWFAMYDTNKVGLVDFIYNRPRPNDDEFPKYEAQYLGIEMFGMKLKQTGGNYMTDGYGSAVQSHIAYTENSSLSQAQVNQKMKDYLGITHHDVVQDPNGEYINHVDCWGKYLAPNKILIRKVPDNHPQHQALEDMAAYFAAQTCAWGTKYEVYRALATNEQPYTNSLILNNRVFVPVNGPASVDNDALNVYKTAMPGYEIIGVKGASGTPWLGTDALHCRTHEVADKGYLYIKHYPILGEQAGPDYKIEADVVSCANATISPVQCYYRINGSGSFKAADMTMESTGHYTYSFTGLNKNDKVEYYISAADNSGRKETYPFIGEPDPFKFTCMNETNTCTVTGAAKALRAWFNAGRSELAVSVSLNIAGTYRIKLYNTAGEEVAAMTKELVAGTSVFSMDVYSQAPGTYVLVVEGNGIRETMKILK
Protein: Acid phosphatase
UniProt accession: Q8I2X3
Organism: Plasmodium falciparum (isolate 3D7)
Taxonomy: Eukaryota, Sar, Alveolata, Apicomplexa, Aconoidasida, Haemosporida, Plasmodiidae, Plasmodium, Plasmodium (Laverania)
Gene names: PF3D7_0918000
Length: 396 residues
Disorder content (fraction disordered): 0.03787878787878788
Curated region start positions: 122
Curated region end positions: 136
Curated region terms: disorder
Domain/feature annotations: Calcineurin-like phosphoesterase
Cross-references: PDB:3TGH
Sequence:
MNYCKTTFHIFFFVLFFITIYEIKCQLRFASLGDWGKDTKGQILNAKYFKQFIKNERVTFIVSPGSNFIDGVKGLNDPAWKNLYEDVYSEEKGDMYMPFFTVLGTRDWTGNYNAQLLKGQGIYIEKNGETSIEKDADATNYPKWIMPNYWYHYFTHFTVSSGPSIVKTGHKDLAAAFIFIDTWVLSSNFPYKKIHEKAWNDLKSQLSVAKKIADFIIVVGDQPIYSSGYSRGSSYLAYYLLPLLKDAEVDLYISGHDNNMEVIEDNDMAHITCGSGSMSQGKSGMKNSKSLFFSSDIGFCVHELSNNGIVTKFVSSKKGEVIYTHKLNIKKKKTLDKVNALQHFAALPNVELTDVPSSGPMGNKDTFVRVVGTIGILIGSVIVFIGASSFLSKNMK
Protein: Uncharacterized protein
UniProt accession: A0A0H3MCR9
Organism: Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Taxonomy: Bacteria, Chlamydiae, Chlamydiales, Chlamydiaceae, Chlamydia/Chlamydophila group, Chlamydia
Gene names: CTL0847
Length: 183 residues
Disorder content (fraction disordered): 0.07103825136612021
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1
Curated region end positions: 13
Curated region terms: disorder
Domain/feature annotations: CT_584-like
Cross-references: PDB:4MLK
Sequence:
MTTKPKTLEIDNNTFLLLEGNLKRIFATPIGYTTFREFQNVVFNCAQGQQELANFLFEMLINGKLLQELPAGQKQSAQSLIVQFMMPIRVAKDIHERGEFINFITSDMLAQQERCVFLNRLSRVDGQEFLLMTDVQNTCHLIRHLLSRLLEAQKNPIGEKNLQEIQEDLDSLRAHFEELTKSV
Protein: Flagellar calcium-binding protein
UniProt accession: P07749
Organism: Trypanosoma cruzi
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Trypanosoma, Schizotrypanum
Gene names: FCABP
Length: 211 residues
Disorder content (fraction disordered): 0.08056872037914692
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1, 1
Curated region end positions: 17, 17
Curated region terms: disorder, disorder
Domain/feature annotations: EF-hand domain pair, FCaBP EF-hand domain
Cross-references: PDB:3CS1
Sequence:
MGACGSKGSTSDKGLASDKDGKKAKDRKEAWERIRQAIPREKTAEAKQRRIELFKKFDKNETGKLCYDEVHSGCLEVLKLDEFTPRVRDITKRAFDKARALGSKLENKGSEDFVEFLEFRLMLCYIYDFFELTVMFDEIDASGNMLVDEEELKRAVPKLEAWGAKVEDPAALFKELDKNGTGSVTFDEFAAWASAVKLDADGDPDNVPESA
Protein: Apical membrane antigen 1
UniProt accession: P50490
Organism: Plasmodium falciparum (isolate FCR-3 / Gambia)
Taxonomy: Eukaryota, Sar, Alveolata, Apicomplexa, Aconoidasida, Haemosporida, Plasmodiidae, Plasmodium, Plasmodium (Laverania)
Gene names: AMA-1, PF83
Length: 622 residues
Disorder content (fraction disordered): 0.12057877813504823
Curated region start positions: 513, 439
Curated region end positions: 546, 479
Curated region terms: disorder, disorder
Domain/feature annotations: Apical membrane antigen 1
Cross-references: PDB:2J5L, PDB:2j5l, PDB:4r1a
Sequence:
MRKLYCVLLLSAFEFTYMINFGRGQNYWEHPYQKSGVYHPINEHREHPKEYEYPLHQEHTYQQEDSGEDENTLQHAYPIDHEGAEPAPQEQNLFSSIEIVERSNYMGNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVFGKGIIIENSNTTFLKPVATGNQDLKDGGFAFPPTNPLISPMTLNGMRDFYKNNEYVKNLDELTLCSRHAGNMNPDNDKNSNYKYPAVYDYNDKKCHILYIAAQENNGPRYCNKDQSKRNSMFCFRPAKDKLFENYTYLSKNVVDNWEEVCPRKNLENAKFGLWVDGNCEDIPHVNEFSANDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNRETQKCEIFNVKPTCLINNSSYIATTALSHPIEVEHNFPCSLYKDEIKKEIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKPTYDNMKIIIASSAAVAVLATILMVYLYKRKGNAEKYDKMDQPQHYGKSTSRNDEMLDPEASFWGEEKRASHTTPVLMEKPYY
Protein: 14-3-3 protein zeta/delta
UniProt accession: P63101
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Ywhaz
Length: 245 residues
Disorder content (fraction disordered): 0.04897959183673469
Curated region start positions: 234
Curated region end positions: 245
Curated region terms: disorder
Domain/feature annotations: 14-3-3 protein
Sequence:
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Protein: Pannexin-1
UniProt accession: Q96RD7
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MRS1, PANX1, UNQ2529/PRO6028
Length: 426 residues
Disorder content (fraction disordered): 0.19014084507042253
Curated region start positions: 163, 163, 374, 374
Curated region end positions: 190, 190, 426, 426
Curated region terms: disorder, flexible linker, disorder, flexible C-terminal tail
Domain/feature annotations: Innexin
Cross-references: PDB:6WBF
Sequence:
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
Protein: Toxin CfTX-1
UniProt accession: A7L035
Organism: Chironex fleckeri
Taxonomy: Eukaryota, Metazoa, Cnidaria, Cubozoa, Chirodropida, Chirodropidae, Chironex
Length: 456 residues
Disorder content (fraction disordered): 0.05701754385964912
Curated region start positions: 22, 22
Curated region end positions: 47, 47
Curated region terms: disorder, disorder to order
Sequence:
MVKMLFFAFLPLLFMTGIAAESTISSGLNSLKTKIDAKMPSGKQLFDKVVEMQKQIDAKFSNDDERAKVMGAIGSLSTAVGKFQSGDPAKIASGCLDILVGISSVLKDFAKFSPIFSILSLVVGLFSGTKAEESVGSVVKKAVQEQSDQELQEALYGVKREYAVSKAFLDGVRNETSDLSPTEVSALAANVPIYQGVRFIAMVVQRIKYIKPKTESEIKRMLTMLELFTDLCSLRDLILLDLYQLVATPGHSPNIASGIKEVSNLGREEYKKVFEDLLKNDDKETYLFLSYLYPREKNEQSRKIFNFFDLMKVKYDDRLKQDLTGVKIFSNVHWPNYFMCSSNDYLALICTKPYGSLKLDKLNDGYYSIKTTQHDPKICHRYGNYILFTHKRNDDLEKFNFVPVKLEKREIYLLSSKESPNKFAYVPQNADGALFFVDGIPSKVGYGNQGYFTLVE
Protein: Alpha-conotoxin VxXXIVA
UniProt accession: J7JU64
Organism: Conus vexillum
Taxonomy: Eukaryota, Metazoa, Spiralia, Lophotrochozoa, Mollusca, Gastropoda, Caenogastropoda, Neogastropoda, Conoidea, Conidae, Conus, Rhizoconus
Length: 68 residues
Disorder content (fraction disordered): 0.5882352941176471
Curated region start positions: 29, 29
Curated region end positions: 68, 68
Curated region terms: disorder, disorder
Sequence:
METLTLLWRASSSCLLVVLSHSLLRLLGVRCLEKSGAQPNKLFRPPCCQKGPSFARHSRCVYYTQSRE
Protein: Uncharacterized protein
UniProt accession: O25555
Organism: Helicobacter pylori (strain ATCC 700392 / 26695)
Taxonomy: Bacteria, Proteobacteria, Epsilonproteobacteria, Campylobacterales, Helicobacteraceae, Helicobacter
Gene names: HP_0895
Length: 125 residues
Disorder content (fraction disordered): 0.24
Dataset labels: Unicellular toxins and antitoxins
Curated region start positions: 96, 96, 96, 96
Curated region end positions: 125, 125, 125, 125
Curated region terms: disorder, protein binding, disorder to order, toxin sequestering activity
Sequence:
MPNTTAKKDYTKYSKKQLFNLIHQLERKIKKMQNDRISFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLGHEIPNIETQQAMRDVGNKETDLIVEDFSSYSNERKRALGVEAQS
Protein: Antitoxin RelB
UniProt accession: P0C079
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW1556, b1564, relB
Length: 79 residues
Disorder content (fraction disordered): 0.4683544303797468
Dataset labels: Unicellular toxins and antitoxins
Curated region start positions: 43, 43, 52, 52, 47, 47, 47, 47, 47, 47
Curated region end positions: 65, 79, 79, 79, 79, 79, 79, 79, 79, 79
Curated region terms: disorder, disorder, protein binding, toxin sequestering activity, disorder, disorder to order, protein binding, toxin sequestering activity, disorder, disorder
Domain/feature annotations: RelB antitoxin
Cross-references: PDB:2KC8
Sequence:
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Protein: Melittin
UniProt accession: P01501
Organism: Apis mellifera
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Arthropoda, Hexapoda, Insecta, Pterygota, Neoptera, Endopterygota, Hymenoptera, Apocrita, Aculeata, Apoidea, Apidae, Apis
Gene names: MELT
Length: 70 residues
Disorder content (fraction disordered): 0.3857142857142858
Curated region start positions: 44, 44, 58, 44, 63, 63, 44
Curated region end positions: 70, 70, 63, 69, 68, 68, 70
Curated region terms: disorder, disorder to order, protein binding, protein binding, lipid binding, localization, molecular function inhibitor activity
Domain/feature annotations: Melittin
Sequence:
MKFLVNVALVFMVVYISYIYAAPEPEPAPEPEAEADAEADPEAGIGAVLKVLTTGLPALISWIKRKRQQG