LiteFold/DisProt huggingface dataset:
Protein: Taurocyamine kinase
UniProt accession: P16641
Organism: Schistosoma mansoni
Taxonomy: Eukaryota, Metazoa, Spiralia, Lophotrochozoa, Platyhelminthes, Trematoda, Digenea, Strigeidida, Schistosomatoidea, Schistosomatidae, Schistosoma
Gene names: Smp_194770
Length: 746 residues
Disorder content (fraction disordered): 0.013404825737265416
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 701
Curated region end positions: 710
Curated region terms: disorder
Domain/feature annotations: ATP:guanido phosphotransferase, C-terminal catalytic domain, ATP:guanido phosphotransferase, C-terminal catalytic domain, ATP:guanido phosphotransferase, N-terminal domain, ATP:guanido phosphotransferase, N-terminal domain
Cross-references: PDB:4WO8, PDB:4WOD
Sequence:
MTCTSAFIKVVRFIQVVIDTREIRSLCTIRMQVESLQNLQAKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGDLIAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTHGEHTESVGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEDFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGLYGEHTESPDGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL
Protein: Uncharacterized protein
UniProt accession: A0A504XZ90
Organism: Leishmania donovani
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: CGC21_38360
Length: 301 residues
Disorder content (fraction disordered): 0.2757475083056478
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1, 184
Curated region end positions: 29, 237
Curated region terms: disorder, disorder
Cross-references: EMDB:11821, PDB:7AM2
Sequence:
MILITSNCARVAAFARKAACRGALCDRHRCISGGGRGDLFTRHASAFKPPAFGVLRGLTHSSQTTHPQTGQLRARKLIQHAMHDRTLSGSGHHRTAVATWSYLLPSLRQNVEQAVPDTLYEKLLTDEVPLTPAESRQLADAHRLLRFELQKRIGLLEDSLADAALPYLLQWPALFQRAWLRLPMDQGSASVTDAKRDAVVPAPPSFVHAPAALPITEWAPTLSPASPSACSNGLIGRGALVPRLAQLTRHVIRCVEEDLGRLEHGSEPREDGAPRSRRQVTLEAAWRAQWASLLSWHAGTS
Protein: Glutathione peroxidase
UniProt accession: Q869A5
Organism: Trypanosoma brucei
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Trypanosoma
Gene names: gpx3
Length: 176 residues
Disorder content (fraction disordered): 0.23295454545454544
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 76
Curated region end positions: 116
Curated region terms: disorder
Domain/feature annotations: Glutathione peroxidase
Cross-references: PDB:2RM5, PDB:2RM6
Sequence:
MLRSSRKKMSAASSIFDFEVLDADHKPYNLVQHKGSPLLIYNVASKCGYTKGGYETATALYNKYKSQGFTVLAFPCNQFGGQEPGTEEEIKEFVCTKFKAEFPIMAKINVNGENAHPLYEYMKKTKPGILATKAIKWNFTSFLIDRDGVPVERFSPGASVKDIEEKLIPLLGSARL
Protein: Ribonuclease H2 subunit C
UniProt accession: Q8TDP1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: AYP1, RNASEH2C
Length: 164 residues
Disorder content (fraction disordered): 0.2682926829268293
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 1, 87, 93
Curated region end positions: 13, 117, 107
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Ribonuclease H2 non-catalytic subunit (Ylr154p-like)
Cross-references: PDB:3P56, PDB:3PUF
Sequence:
MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED
Protein: Histone H3.3
UniProt accession: P84243
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: H3-3A, H3-3B, H3.3A, H3.3B, H3F3, H3F3A, H3F3B, PP781
Length: 136 residues
Disorder content (fraction disordered): 0.27941176470588236
Dataset labels: NDDs-related proteins, Cancer-related proteins
Curated region start positions: 1
Curated region end positions: 38
Curated region terms: disorder
Domain/feature annotations: Core histone H2A/H2B/H3/H4 domain
Cross-references: PDB:6A5L, PDB:6A5O, PDB:6A5P, PDB:6A5R, PDB:6A5T, PDB:6A5U, PDB:6INQ
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: Glutathione S-transferase omega-like 2
UniProt accession: P36156
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: ECM4, GTO2, YKR076W
Length: 370 residues
Disorder content (fraction disordered): 0.05405405405405406
Curated region start positions: 1, 84
Curated region end positions: 10, 93
Curated region terms: disorder, disorder
Domain/feature annotations: Glutathione S-transferase, N-terminal domain, Glutathione S-transferase, C-terminal domain
Cross-references: PDB:5LKB, PDB:5LKD
Sequence:
MSKQWASGTNGAFKRQVSSFRETISKQHPIYKPAKGRYWLYVSLACPWAHRTLITRALKGLTSVIGCSVVHWHLDEKGWRFLDMEKQLEDSEDFLEHWHDVAGGIRTAKEDSSKSFAEIKNDSQRFMVDATNEPHYGYKRISDLYYKSDPQYSARFTVPVLWDLETQTIVNNESSEIIRILNSSAFDEFVDDDHKKTDLVPAQLKTQIDDFNSWVYDSINNGVYKTGFAEKAEVYESEVNNVFEHLDKVEKILSDKYSKLKAKYGEEDRQKILGEFFTVGDQLTEADIRLYTTVIRFDPVYVQHFKCNFTSIRAGYPFIHLWVRNLYWNYDAFRYTTDFDHIKLHYTRSHTRINPLGITPLGPKPDIRPL
Protein: Phosphodiesterase
UniProt accession: Q8WQX9
Organism: Trypanosoma brucei
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Trypanosoma
Gene names: PDEB1
Length: 930 residues
Disorder content (fraction disordered): 0.02258064516129032
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 576, 565
Curated region end positions: 585, 585
Curated region terms: disorder, disorder
Domain/feature annotations: 3'5'-cyclic nucleotide phosphodiesterase, GAF domain, GAF domain
Cross-references: PDB:4I15, PDB:5G2B, PDB:5G57, PDB:5G5V, PDB:5L8C, PDB:5L8Y, PDB:5L9H
Sequence:
MFMNKPFGSKRCEPFHESEHLCEAFAITEAILARYQRGKRSFTSSEKSGLAALIKRIPYDILVEVLDQSGFTPTSNATPPVDYLAMMEHTMTHGASITHALQYLNDLMTKCTGCPGIRTYYHNPNDDVLADPVHDTAALIDETTAVGKSVVTKQYLNIAGAHYIPLIHGDIVVGCVEVPRFSGNLEKLPSFPSLIRAVTCTAHKFIEEARINWNREKAEAMLQMATRLARDNLDETVLASSIMNTVKSLTESARCSLFLVKDDKLEAHFEDGNVVSIPKGTGIVGYVAQTGETVNIVDAYADDRFNREVDKATGYRTKTILCMPVMYEGTIVAVTQLINKLDLTTESGLRLPRVFGKRDEELFQTFSMFAGASLRNCRINDRLLKEKKKSDVILDVVTVLSNTDIRDVDGIVRHALHGAKKLLNADRSTLFLVDKERNELCSRMADSVAGKEIRFPCGQGIAGTVAASGVGENIQDAYQDPRFNREVDKQLGYRTQTILCEPIILNGEILAVVQLVNKLDTSGEVTVFTEDDRDTFRVFSLFAGISINNSHLLEFAVKAGREVMELNEHRATLFNKNVPSRAVKRVTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRLLLGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIHTFLYRGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSASGNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDMAKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQWAMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPFFQKIVDACLQGMQWTVDRIKSNRAQWERVLETRLSTSSGNNSSTR
Protein: Farnesyl pyrophosphate synthase
UniProt accession: Q86C09
Organism: Trypanosoma brucei
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Trypanosoma
Length: 367 residues
Disorder content (fraction disordered): 0.027247956403269755
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 64
Curated region end positions: 73
Curated region terms: disorder
Domain/feature annotations: Polyprenyl synthetase
Cross-references: PDB:2P1C
Sequence:
MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLSPNNNGEEDDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK
Protein: Disulfide-bond oxidoreductase YfcG
UniProt accession: P77526
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW2299, b2302, yfcG
Length: 215 residues
Disorder content (fraction disordered): 0.05116279069767442
Curated region start positions: 205
Curated region end positions: 215
Curated region terms: disorder
Domain/feature annotations: Glutathione S-transferase, C-terminal domain, Glutathione S-transferase, N-terminal domain
Cross-references: PDB:3GX0
Sequence:
MIDLYFAPTPNGHKITLFLEEAELDYRLIKVDLGKGGQFRPEFLRISPNNKIPAIVDHSPADGGEPLSLFESGAILLYLAEKTGLFLSHETRERAATLQWLFWQVGGLGPMLGQNHHFNHAAPQTIPYAIERYQVETQRLYHVLNKRLENSPWLGGENYSIADIACWPWVNAWTRQRIDLAMYPAVKNWHERIRSRPATGQALLKAQLGDERSDS
Protein: Transcription antitermination protein RfaH
UniProt accession: P0AFW0
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW3818, b3842, hlyT, rfaH, sfrB
Length: 162 residues
Disorder content (fraction disordered): 0.08641975308641975
Curated region start positions: 101, 101
Curated region end positions: 114, 114
Curated region terms: disorder, flexible linker
Domain/feature annotations: Transcription termination factor nusG
Cross-references: PDB:2OUG
Sequence:
MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPATPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL
Protein: Putative dynein intermediate chain protein
UniProt accession: G0SCF1
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Pezizomycotina, Sordariomycetes, Sordariomycetidae, Sordariales, Chaetomiaceae, Thermochaetoides
Gene names: CTHT_0056990
Length: 707 residues
Disorder content (fraction disordered): 0.18528995756718528
Curated region start positions: 31, 31, 50, 77
Curated region end positions: 88, 88, 64, 161
Curated region terms: disorder, protein binding, protein binding, disorder
Domain/feature annotations: WD domain, G-beta repeat, WD domain, G-beta repeat
Cross-references: PDB:6PQT
Sequence:
MQARREELLAKKARLAEIKRQRELRAQQAAGRSITPSELVSPTPSRANSRREIESLIDSILSSSAGANSPRRGSRPNSVISTGELSTDNASEITATTTGQLPSQPQPLSTVPLQTVYECPPSPVKEIISYSKGVQTTEEWTPRKSRGVGDSDDEDLGAAASPSKRLSRRERDREEELREKIRKEIEEELKATKELVADGVLKQSGAQNFPVRALTAEELDAVTKSVEFMDFIDRSTKVIEKALDQEYDILTDYTLQVHDVEDEDEQSGNVGGKGRRKVREIAQFYDERWSKKRMISSIDFSPKFSELLLASYTKNPTAPHDPDGIVQVWNLHLHDRPEFVFHAQSDILTAKFSPFHPNLIIGGAYSGQVLLWDTRARSAPVQKTPLTGSGHTHPVYCIDIVGTQNANNIISCSTDGAVCGWSVDMLAQPQESLTLLAPLPAKSEDLSPTCMAFPQADPTFFLVGTEEGTIYPCHRYDRAGAKAGVDPRVSYRGHAGPVMSVAFHPARGPVDLGDLVLSSSLDWSVKLWKVRAPAATSGVLSSGSVTSPSAAAAAAAAAAAVTAPLPGSTTGSLDSQVTPLLDLVREDVVYDAAWSPIKPGVFGLVDGAGTLEIWDITVETEEPVARVVPTPRKDRGALLGMKSLNKVAWEPSEGKRLATGGLDGVVSMFEVGPDLGGKEGLRNEDWGTVKKLVNRLEAGGSVDGVGM
Protein: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2
UniProt accession: P22108
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: APA2, D9719.33, YDR530C
Length: 325 residues
Disorder content (fraction disordered): 0.033846153846153845
Curated region start positions: 53
Curated region end positions: 63
Curated region terms: disorder
Domain/feature annotations: ATP adenylyltransferase C-terminal domain, Ap4A phosphorylase N-terminal domain
Cross-references: PDB:4I5T, PDB:4I5W
Sequence:
MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSLALKPDANKNSDSKAEDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDLMTAYNVLCSLQGDKDDDVTCERYLVFYNCGPHSGSSQDHKHLQIMQMPEKFIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLLAMCYVSLMQRALTFFQDWTNESPELTKSYNVLLTKKWICVVPRSHAKSGPPLMLNINSTGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQKPTEYHY
Protein: SERF-like protein YDL085C-A
UniProt accession: Q3E7B7
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: YDL085C-A
Length: 68 residues
Disorder content (fraction disordered): 0.5147058823529411
Curated region start positions: 1
Curated region end positions: 35
Curated region terms: disorder
Domain/feature annotations: Small EDRK-rich factor 1/2-like, N-terminal
Cross-references: BMRB:51051, BMRB:51287
Sequence:
MARGNQRDLARQKNLKKQKDMAKNQKKSGDPKKRMESDAEILRQKQAAADARREAEKLEKLKAEKTRR
Protein: Cold-inducible RNA-binding protein
UniProt accession: Q14011
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: A18HNRNP, CIRBP, CIRP
Length: 172 residues
Disorder content (fraction disordered): 0.48255813953488375
Dataset labels: Condensates-related proteins, RNA-binding proteins
Curated region start positions: 90
Curated region end positions: 172
Curated region terms: disorder
Domain/feature annotations: RNA recognition motif
Cross-references: BMRB:51517
Sequence:
MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE
Protein: Large delta antigen
UniProt accession: O39946
Organism: Hepatitis delta virus
Taxonomy: Viruses, Ribozyviria, Kolmioviridae, Deltavirus
Length: 214 residues
Disorder content (fraction disordered): 0.35514018691588783
Dataset labels: Viral proteins
Curated region start positions: 61, 150
Curated region end positions: 91, 194
Curated region terms: disorder, disorder
Domain/feature annotations: Hepatitis delta virus delta antigen
Cross-references: BMRB:51340
Sequence:
MSRSESRKNRGGREEILEQWVAGRKKLEELERDLRKTKKKLKKIEDENPWLGNIKGILGKKDKDGEGAPPAKRARTDQMEVDSGPGKRPLRGGFTDKERQDHRRRKALENKKKQLSAGGKNLSKEEEEELRRLTEEDERRERRVAGPPVGGVNPLEGGSRGAPGGGFVPNLQGVPESPFSRTGEGLDIRGNQGFPWDILFPADPPFSPQSCRPQ
Protein: C3H1-type domain-containing protein
UniProt accession: D8SB57
Organism: Selaginella moellendorffii
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Lycopodiopsida, Selaginellales, Selaginellaceae, Selaginella
Gene names: SELMODRAFT_112852
Length: 119 residues
Disorder content (fraction disordered): 0.1176470588235294
Curated region start positions: 39
Curated region end positions: 52
Curated region terms: disorder
Domain/feature annotations: Zinc finger C-x8-C-x5-C-x3-H type (and similar), Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Cross-references: BMRB:51209, BMRB:51210
Sequence:
MAEESDASKLYKTELCRSWEETGSCRYGNKCQFAHGKEDLRPVNRHPKYKTEVCRTFSAAGTCPYGKRCRFIHATPKLSDVKLPPLVAPAMNLTKLLLHDNAAAMAPRSRLPVFREICL
Protein: B6 protein
UniProt accession: A5Y0M2
Organism: Trichonephila antipodiana
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Arthropoda, Chelicerata, Arachnida, Araneae, Araneomorphae, Entelegynae, Araneoidea, Nephilidae, Trichonephila
Length: 270 residues
Disorder content (fraction disordered): 0.07777777777777778
Curated region start positions: 92
Curated region end positions: 112
Curated region terms: disorder
Cross-references: BMRB:36395
Sequence:
EFAKCMYELVLKSANSLGVLNPHLIANNIYQSIVSNLDILHSSVMINLYANAMARNLFHEGFLNLDNAATLAKKCANDMEAFAKKMVETGPNLSIGDTTSIIQLFKNFTGPPSVATFISNFHSIVQSSKTLLNLFDVAEENPLEFAKCMYELVLKSANSLGVLNPHLIANNIYQSVVSNLDILHSSAMVNLYANAMAGSLFLEGILNSDNAATLAKKCANDMEAFAKKMVEIGNSISNIQDFPDVSARILGNLSLPLLDDVLDLLSSFLP
Protein: Stromal interaction molecule 1
UniProt accession: Q13586
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GOK, STIM1
Length: 685 residues
Disorder content (fraction disordered): 0.0145985401459854
Dataset labels: NDDs-related proteins
Curated region start positions: 395
Curated region end positions: 404
Curated region terms: disorder
Domain/feature annotations: SAM domain (Sterile alpha motif), STIM1 Orai1-activating region, Stromal interaction molecule 1-like, EF-hand
Cross-references: BMRB:50683
Sequence:
MDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMSRAADEALNAMTSNGSHRLIEGVHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRNTRIPHLAGKKAVAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK
Protein: p17 protein
UniProt accession: Q9R825
Organism: Borreliella afzelii
Taxonomy: Bacteria, Spirochaetes, Spirochaetales, Borreliaceae, Borreliella
Gene names: p17
Length: 150 residues
Disorder content (fraction disordered): 0.12
Curated region start positions: 31
Curated region end positions: 48
Curated region terms: disorder
Domain/feature annotations: Decorin binding protein
Cross-references: BMRB:50751
Sequence:
MSLTGKARLESSVKDITNEIEKAIKEAEDAGVKTDAFTETQTGGKVGGSQIRAAKIRVADLTIKFLEATEEETITFKENGAGEEDFSGIYDLILNAAKAVEKIGMQGMKQAVEEAAKEKPKTTADGIIAIVKVMKAKVENIKEKQTKNQK
Protein: Disks large homolog 4
UniProt accession: P78352
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DLG4, PSD95
Length: 724 residues
Disorder content (fraction disordered): 0.09806629834254144
Dataset labels: NDDs-related proteins, Condensates-related proteins
Curated region start positions: 1
Curated region end positions: 71
Curated region terms: disorder
Domain/feature annotations: SH3 domain, PDZ domain, PDZ domain, PDZ domain, Guanylate kinase, PDZ-associated domain of NMDA receptors, Polyubiquitination (PEST) N-terminal domain of MAGUK
Cross-references: BMRB:50752
Sequence:
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
Protein: Methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein
UniProt accession: Q4Q5U3
Organism: Leishmania major
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: LMJF_31_3130
Length: 687 residues
Disorder content (fraction disordered): 0.023289665211062592
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 602
Curated region end positions: 617
Curated region terms: disorder
Domain/feature annotations: Biotin carboxylase, N-terminal domain, Biotin-requiring enzyme, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, ATP binding domain
Cross-references: BMRB:50309
Sequence:
MLRRTDRCGQRKVEKLLVANRGEIACRVFRTCREMHIRTVALFCEAERNAKHVVEADEAVCIGPPPAVNSYLRGDHIISVAKQLNVDAIHPGYGFLSENADFAEAVTRSGIEFIGPPASAISLMGSKSESKRIMEAAGVPVVPGYYGENQNVSFLAEEANRVGFPILIKAVSGGGGKGMKIVERPEDFAFMLESAKREAANFFKDDRVILERYVKRPRHIECQIFFDKHGRGVFFFERDCSVQRRYQKVLEEAPAPHLSMEMRQRIGEVALQAAKAVGYVGAGTVEFIFDTSTGDFYFMEMNTRLQVEHPVTEEVCRIKGAPLDLVKLQIKTAMGKPLTFSQEDVALVGSCIEARVYAESPERGFLPESGPLTFIREPFQGVRGPTRTRLDTGFCEGDNVLIHYDPMLAKVISWGRNREDALKGLRQALGEYKVAGINTNIEFLKRCCEAPEFARGGVTTNFISEHEKQLLNAPAVTPKVAAMAATAWLLNRCDNWRGAFRLNGDTSATVHFYIDNRPVEVRLHTEGANYHKIFFSVWDHEGSFAVGSGPVTSKHRDQRSIVNGFTFLFENGMRHTVLAVATEGDVTIIGSFGLHQIRLLPLTDGFGDASMAGGTSAKIVSPMPGKVSKFLVNSGDFVEKGQALMIVEAMKMEHPVKALQDGQVSFLVKEGEVVGSDHVLATVVQKE
Protein: G-protein-signaling modulator 2
UniProt accession: P81274
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GPSM2, LGN
Length: 684 residues
Disorder content (fraction disordered): 0.2149122807017544
Dataset labels: NDDs-related proteins
Curated region start positions: 355, 275
Curated region end positions: 421, 421
Curated region terms: disorder, disorder
Domain/feature annotations: GoLoco motif, GoLoco motif, GoLoco motif, GoLoco motif, Tetratricopeptide repeat, Tetratricopeptide repeat, Tetratricopeptide repeat, Tetratricopeptide repeat, Tetratricopeptide repeat
Cross-references: PDB:4WND, PDB:4WNE, PDB:4WNF, PDB:4WNG
Sequence:
MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDILVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQNRDTDFGLKDFLQNNALLEFKNSGKKSADH
Protein: Peptide synthetase PaxA
UniProt accession: W1J0W9
Organism: Xenorhabdus cabanillasii JM26
Taxonomy: Bacteria, Pseudomonadota, Gammaproteobacteria, Enterobacterales, Morganellaceae, Xenorhabdus
Gene names: XCR1_180002, paxA
Length: 1084 residues
Disorder content (fraction disordered): 0.05627306273062731
Curated region start positions: 982, 1070, 1073, 1073
Curated region end positions: 1027, 1084, 1082, 1082
Curated region terms: disorder, disorder, disorder to order, protein binding
Domain/feature annotations: AMP-binding enzyme, Phosphopantetheine attachment site, Condensation domain, AMP-binding enzyme C-terminal domain
Cross-references: BMRB:34575, BMRB:50594
Sequence:
MNYPDTLKSFALSEAQSSRWFQYQINPAQRGQNNSAFCARVKGLTAEKLEDALNHLIKRHPMLRASFGQYDGKLGYQIAENAVIKITRHNARDLSEETLQQVVRNDCWHAFDLNNPLRVYASWYQCDDQESVMVLTFDHLAVDGWSYWILLEELGKLLTEQELPPAPERSYQDYVIWQQQWLNSNNAKKQQQFWCDNLSGHLTELQLPASNKPVINQSPSATDKITVPGKLSDTLARKLLVMAEKYGNSLFAIFLAAYQILLHRYTGQDDIFIGSIMPGRSRAPWGKLVGEFVNPVALRGQINDEMTVQEHILQAAKTIRQAIENQKYPFPKILEQIKVQRHADTHPVFQTIMTFQQPRYISNLVSLWMDQSSSTTVHWGGAELRSFPYPYYAEMPVPLMVNVIEVDQQINCGFHYDTKLFDAELITQLMNNFFNLLTAMADDEQQTIDSLPLMNESERQRILYNFNATDISYPQNVLLHQLFEQQVNYTPAAIALICDNHQLTYEELNRQANKLAHAFVAAGIQADNRIGLCMERSPEMVIALLGILKAGAAYVPLDPEYPADRLRHILTDSEPALVLSHHGLQSHLPDTSVPLWIWESGEFQATITEQQEDNLSITDLGLTSRNLAYVLYTSGSTGLPKGVMNEHRGIVNRLLWAKDEYQLNPNDLVLQKTPFSFDVSVWEFFLPLLAGAQLVMARPGGHKDPLYLLEEIESRGITTLHFVPSMLQSFIHLTPAERCPSLRQILCSGEALPYSLQQQCLSHFPHSELHNLYGPTEAAIDVTSWRCGSEKYVDLVPIGHPIANTQIYILDKLGRLVPIGVTGEIHIGGIGVARGYLNRPELTAERFVHDPFSNLPDARMYKTGDLGRWLPDGSIDYLGRNDFQVKIRGNRIELEEIETRLAQCAGVQQVVVVARAYDSADTRLIAYIIPQSGTTLNIPELREQLGNSLPDYMIPGAFVMLDTFPLTLSGKLDRRALPIPDHSSVITQEYAAPQGEIEEQLADIWQTILKIDRIGRYDNFFELGGHSLLVLQLQSRINEIFDVDISIQQLFAHPSICQLEECIINAQLLQFDADSLQDIYKSME