LiteFold/DisProt huggingface dataset:
Protein: Glutaminase kidney isoform, mitochondrial
UniProt accession: O94925
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GLS, GLS1, KIAA0838
Length: 669 residues
Disorder content (fraction disordered): 0.13452914798206278
Dataset labels: NDDs-related proteins
Curated region start positions: 71, 72, 646, 72
Curated region end positions: 135, 135, 669, 136
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Glutaminase, Ankyrin repeats (3 copies), EF-hand domain
Cross-references: PDB:3UNW, PDB:3UO9, PDB:5FI2, PDB:5FI6, PDB:5FI7, PDB:5I94, PDB:5U0I, PDB:5U0J, PDB:5WJ6
Sequence:
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
Protein: Gephyrin
UniProt accession: Q9NQX3
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GPH, GPHN, KIAA1385
Length: 736 residues
Disorder content (fraction disordered): 0.016304347826086956
Dataset labels: NDDs-related proteins, Cancer-related proteins
Curated region start positions: 1
Curated region end positions: 12
Curated region terms: disorder
Domain/feature annotations: Probable molybdopterin binding domain, Probable molybdopterin binding domain, MoeA N-terminal region (domain I and II), MoeA C-terminal region (domain IV)
Cross-references: PDB:1JLJ
Sequence:
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
Protein: Hypoxanthine-guanine phosphoribosyltransferase
UniProt accession: P00492
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HPRT, HPRT1
Length: 218 residues
Disorder content (fraction disordered): 0.10091743119266056
Dataset labels: NDDs-related proteins, Age-related disorders proteins
Curated region start positions: 104, 104, 103, 102
Curated region end positions: 123, 113, 119, 121
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Phosphoribosyl transferase domain
Cross-references: PDB:4KN6, PDB:4RAB, PDB:4RAC, PDB:4RAN, PDB:4RAQ, PDB:5BRN, PDB:5BSK
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
Protein: Acyl carrier protein
UniProt accession: E9AD06
Organism: Leishmania major
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: ACP, LMJF_27_0290
Length: 150 residues
Disorder content (fraction disordered): 0.44
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1
Curated region end positions: 66
Curated region terms: disorder
Domain/feature annotations: Phosphopantetheine attachment site
Cross-references: PDB:7AM2
Sequence:
MQRQVIRRLGNRSAFPLVAAVARSSQIRGAVRGDSGSRARVIPSFMCSLRAYSGGHHEEPSSRSGQYLLDKSDVLTRVLEVVKNFEKVDASKVTPESHFVKDLGLNSLDVVEVVFAIEQEFILDIPDHDAEKIQSIPDAVEYIAQNPMAK
Protein: Small nuclear ribonucleoprotein-associated proteins B and B'
UniProt accession: P14678
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: COD, SNRPB, SNRPB1
Length: 240 residues
Disorder content (fraction disordered): 0.7166666666666667
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 90, 50, 92, 88, 46
Curated region end positions: 229, 62, 240, 174, 64
Curated region terms: disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: LSM domain
Cross-references: EMDB:EMD-4658, EMDB:EMD-4665, EMDB:EMD-9621, PDB:3CW1, PDB:6AH0, PDB:6QW6, PDB:6QX9
Sequence:
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPMPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMGRGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGPPPPGMRPPRP
Protein: Minor curlin subunit
UniProt accession: P0ABK7
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW1024, b1041, csgB
Length: 151 residues
Disorder content (fraction disordered): 1
Dataset labels: Extracellular matrix proteins, Condensates-related proteins
Curated region start positions: 1, 1, 1, 1, 1, 1
Curated region end positions: 151, 151, 151, 151, 151, 151
Curated region terms: disorder, disorder to order, disorder to order, amyloid fibril formation, regulation of amyloid fibril formation, regulation of amyloid fibril formation
Domain/feature annotations: Curlin associated repeat, Curlin associated repeat
Cross-references: AmyPro:AP00037
Sequence:
MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQLRQGGSKLLAVVAQEGSSNRAKIDQTGDYNLAYIDQAGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAIVVQRQSQMAIRVTQR
Protein: 3-hydroxyacyl-CoA dehydrogenase type-2
UniProt accession: Q99714
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ERAB, HADH2, HSD17B10, MRPP2, SCHAD, SDR5C1, XH98G2
Length: 261 residues
Disorder content (fraction disordered): 0.1532567049808429
Dataset labels: NDDs-related proteins
Curated region start positions: 95, 208, 97
Curated region end positions: 113, 228, 102
Curated region terms: disorder, disorder, protein binding
Domain/feature annotations: short chain dehydrogenase
Cross-references: PDB:1SO8
Sequence:
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP
Protein: Alpha-L-iduronidase
UniProt accession: P35475
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: IDUA
Length: 653 residues
Disorder content (fraction disordered): 0.016845329249617153
Dataset labels: NDDs-related proteins
Curated region start positions: 643
Curated region end positions: 653
Curated region terms: disorder
Domain/feature annotations: Glycosyl hydrolases family 39, Alpha-L-iduronidase C-terminal domain
Cross-references: PDB:4KGJ, PDB:4KGL, PDB:4KH2, PDB:4MJ2, PDB:4MJ4
Sequence:
MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP
Protein: Insulin-like growth factor I
UniProt accession: P05019
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: IBP1, IGF1
Length: 195 residues
Disorder content (fraction disordered): 0.1076923076923077
Dataset labels: NDDs-related proteins
Curated region start positions: 70
Curated region end positions: 90
Curated region terms: disorder
Domain/feature annotations: Insulin/IGF/Relaxin family
Cross-references: PDB:6FF3
Sequence:
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK
Protein: Kinesin-like protein KIF7
UniProt accession: Q2M1P5
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: KIF7, UNQ340/PRO539
Length: 1343 residues
Disorder content (fraction disordered): 0.16381236038719285
Dataset labels: NDDs-related proteins
Curated region start positions: 349, 349, 261, 230
Curated region end positions: 543, 398, 273, 241
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Kinesin motor domain, KIF21A-like domain
Cross-references: PDB:2XT3, PDB:4A14, PDB:6MLQ, PDB:6MLR, PDB:7RX0
Sequence:
MGLEAQRLPGAEEAPVRVALRVRPLLPKELLHGHQSCLQVEPGLGRVTLGRDRHFGFHVVLAEDAGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLLEDEQGIVPRAMAEAFKLIDENDLLDCLVHVSYLEVYKEEFRDLLEVGTASRDIQLREDERGNVVLCGVKEVDVEGLDEVLSLLEMGNAARHTGATHLNHLSSRSHTVFTVTLEQRGRAPSRLPRPAPGQLLVSKFHFVDLAGSERVLKTGSTGERLKESIQINSSLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRPEAERPPEETASGARGPPRHRSETRIIHRGRRAPGPATASAAAAMRLGAECARYRACTDAAYSLLRELQAEPGLPGAAARKVRDWLCAVEGERSALSSASGPDSGIESASVEDQAAQGAGGRKEDEGAQQLLTLQNQVARLEEENRDFLAALEDAMEQYKLQSDRLREQQEEMVELRLRLELVRPGWGGPRLLNGLPPGSFVPRPHTAPLGGAHAHVLGMVPPACLPGDEVGSEQRGEQVTNGREAGAELLTEVNRLGSGSSAASEEEEEEEEPPRRTLHLRRNRISNCSQRAGARPGSLPERKGPELCLEELDAAIPGSRAVGGSKARVQARQVPPATASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQALNRQHSQRIRELEQEAEQVRAELSEGQRQLRELEGKELQDAGERSRLQEFRRRVAAAQSQVQVLKEKKQATERLVSLSAQSEKRLQELERNVQLMRQQQGQLQRRLREETEQKRRLEAEMSKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRLEHLEKELSEKSGQLRQGSAQSQQQIRGEIDSLRQEKDSLLKQRLEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRASASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYWLEVALERQRLEMDRQLTLQQKEHEQNMQLLLQQSRDHLGEGLADSRRQYEARIQALEKELGRYMWINQELKQKLGGVNAVGHSRGGEKRSLCSEGRQAPGNEDELHLAPELLWLSPLTEGAPRTREETRDLVHAPLPLTWKRSSLCGEEQGSPEELRQREAAEPLVGRVLPVGEAGLPWNFGPLSKPRRELRRASPGMIDVRKNPL
Protein: GTPase KRas
UniProt accession: P01116
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: KRAS, KRAS2, RASK2
Length: 189 residues
Disorder content (fraction disordered): 0.17989417989417988
Dataset labels: NDDs-related proteins, Cancer-related proteins, Condensates-related proteins
Curated region start positions: 174, 167, 60, 60
Curated region end positions: 189, 189, 70, 64
Curated region terms: disorder, disorder, disorder, GTPase activity
Domain/feature annotations: Ras family
Cross-references: PDB:4WA7, PDB:5OCG, PDB:7VVB
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
Protein: Lon protease homolog, mitochondrial
UniProt accession: P36776
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: LONP1, PRSS15
Length: 959 residues
Disorder content (fraction disordered): 0.17935349322210636
Dataset labels: NDDs-related proteins
Curated region start positions: 1, 222
Curated region end positions: 122, 271
Curated region terms: disorder, disorder
Domain/feature annotations: ATPase family associated with various cellular activities (AAA), ATP-dependent protease La (LON) substrate-binding domain, Lon protease (S16) C-terminal proteolytic domain, Lon protease AAA+ ATPase lid domain
Cross-references: PDB:7NFY, PDB:7NG4, PDB:7NG5, PDB:7NGP, PDB:7NGQ, PDB:7OXO
Sequence:
MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER
Protein: Amine oxidase [flavin-containing] A
UniProt accession: P21397
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MAOA
Length: 527 residues
Disorder content (fraction disordered): 0.14041745730550284
Dataset labels: NDDs-related proteins
Curated region start positions: 465, 1, 507
Curated region end positions: 527, 11, 527
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Flavin containing amine oxidoreductase
Cross-references: PDB:2BXR, PDB:2BXS
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Protein: Mitogen-activated protein kinase 1
UniProt accession: P28482
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Length: 360 residues
Disorder content (fraction disordered): 0.08333333333333333
Dataset labels: NDDs-related proteins, Autophagy-related proteins, Cancer-related proteins
Curated region start positions: 1, 175
Curated region end positions: 15, 189
Curated region terms: disorder, disorder
Domain/feature annotations: Protein kinase domain
Cross-references: PDB:1PME, PDB:5BUE, PDB:5BUJ
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Protein: Malonyl-CoA decarboxylase, mitochondrial
UniProt accession: O95822
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MLYCD
Length: 493 residues
Disorder content (fraction disordered): 0.056795131845841784
Dataset labels: NDDs-related proteins
Curated region start positions: 344
Curated region end positions: 371
Curated region terms: disorder
Domain/feature annotations: Malonyl-CoA decarboxylase C-terminal domain, Malonyl-CoA decarboxylase N-terminal domain
Cross-references: PDB:2YGW
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
Protein: Methylmalonic aciduria type A protein, mitochondrial
UniProt accession: Q8IVH4
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MMAA
Length: 418 residues
Disorder content (fraction disordered): 0.06698564593301436
Dataset labels: NDDs-related proteins
Curated region start positions: 182, 268, 182, 268
Curated region end positions: 197, 279, 197, 279
Curated region terms: disorder, disorder, flexible linker, flexible linker
Domain/feature annotations: Methylmalonyl Co-A mutase-associated GTPase MeaB
Cross-references: PDB:2WWW
Sequence:
MPMLLPHPHQHFLKGLLRAPFRCYHFIFHSSTHLGSGIPCAQPFNSLGLHCTKWMLLSDGLKRKLCVQTTLKDHTEGLSDKEQRFVDKLYTGLIQGQRACLAEAITLVESTHSRKKELAQVLLQKVLLYHREQEQSNKGKPLAFRVGLSGPPGAGKSTFIEYFGKMLTERGHKLSVLAVDPSSCTSGGSLLGDKTRMTELSRDMNAYIRPSPTRGTLGGVTRTTNEAILLCEGAGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVAVTKSDGDLIVPARRIQAEYVSALKLLRKRSQVWKPKVIRISARSGEGISEMWDKMKDFQDLMLASGELTAKRRKQQKVWMWNLIQESVLEHFRTHPTVREQIPLLEQKVLIGALSPGLAADFLLKAFKSRD
Protein: Cyanocobalamin reductase / alkylcobalamin dealkylase
UniProt accession: Q9Y4U1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MMACHC
Length: 282 residues
Disorder content (fraction disordered): 0.18439716312056736
Dataset labels: NDDs-related proteins
Curated region start positions: 231
Curated region end positions: 282
Curated region terms: disorder
Domain/feature annotations: Methylmalonic aciduria and homocystinuria type C family
Cross-references: PDB:3SOM
Sequence:
MEPKVAELKQKIEDTLCPFGFEVYPFQVAWYNELLPPAFHLPLPGPTLAFLVLSTPAMFDRALKPFLQSCHLRMLTDPVDQCVAYHLGRVRESLPELQIEIIADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVEADPWGNQRISGVCIHPRFGGWFAIRGVVLLPGIEVPDLPPRKPHDCVPTRADRIALLEGFNFHWRDWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGLAQPSEKPSSPSPDLPFTTPAPKKPGNPSRARSWLSPRVSPPASPGP
Protein: Cobalamin trafficking protein CblD
UniProt accession: Q9H3L0
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: C2orf25, CL25022, HSPC161, MMADHC, My011
Length: 296 residues
Disorder content (fraction disordered): 0.08783783783783784
Dataset labels: NDDs-related proteins
Curated region start positions: 108, 108
Curated region end positions: 133, 132
Curated region terms: disorder, disorder
Domain/feature annotations: Methylmalonic aciduria and homocystinuria type D protein
Cross-references: PDB:5CUZ, PDB:5CV0, PDB:6X8Z
Sequence:
MANVLCNRARLVSYLPGFCSLVKRVVNPKAFSTAGSSGSDESHVAAAPPDICSRTVWPDETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSLVHKTLPDVLAEPLSSERHEFVMAQYVNEFQGNDAPVEQEINSAETYFESARVECAIQTCPELLRKDFESLFPEVANGKLMILTVTQKTKNDMTVWSEEVEIEREVLLEKFINGAKEICYALRAEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATPDSHIMKKLSGN
Protein: Methylmalonyl-CoA mutase, mitochondrial
UniProt accession: P22033
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MMUT, MUT
Length: 750 residues
Disorder content (fraction disordered): 0.032
Dataset labels: NDDs-related proteins
Curated region start positions: 12, 12
Curated region end positions: 35, 26
Curated region terms: disorder, disorder
Domain/feature annotations: Methylmalonyl-CoA mutase, B12 binding domain
Cross-references: PDB:2XIJ, PDB:2XIQ, PDB:3BIC
Sequence:
MLRAKNQLFLLSPHYLRQVKESSGSRLIQQRLLHQQQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIKPLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYTLADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDAVEVLAIDNTSVRNRQIEKLKKIKSSRDQALAERCLAALTECAASGDGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGISTLAAGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTRIPKAAVQVLDDIEKCLEKKQQSV
Protein: NAD-dependent protein deacetylase
UniProt accession: A0A6L0XH39
Organism: Leishmania infantum
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: LINJ_26_0200, SIR2, SIR2RP1, TbSIR2, TbSIR2RP1
Length: 373 residues
Disorder content (fraction disordered): 0.13404825737265416
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 304, 268, 268, 361
Curated region end positions: 323, 284, 284, 373
Curated region terms: disorder, disorder, flexible linker, disorder
Domain/feature annotations: Sir2 family
Cross-references: PDB:5OL0
Sequence:
MTASPRAPHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFRSPDTGIYANLGKYNLEDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSRCSTCGGIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFALLPCVVPKSVPRVVMNRERVGGLLFRFPDDPLNTVHEDAVAKEGRSSSSQSRSPSASPRREEGGTEDSPSSPNEEVEEASTSSSSDGYGQYGDYHAHPDVCRDVLFRGDCQENVVTLAEYLGLSEALAKRMRLSDAAPATAQRAPNET
Protein: HASPA protein
UniProt accession: O77299
Organism: Leishmania donovani
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: HASPA
Length: 80 residues
Disorder content (fraction disordered): 1
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1
Curated region end positions: 80
Curated region terms: disorder
Sequence:
MGSSCTKDSAKESQKRADNIDTTTRSDEKDGIHVQESAGPVQENFGDAQEKNEDGHNVGDGANGNEDGNDNQPKEHAAGN