LiteFold/DisProt huggingface dataset:
Protein: Bcl-2-like protein 1
UniProt accession: Q07817
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BCL2L, BCL2L1, BCLX
Length: 233 residues
Disorder content (fraction disordered): 0.24034334763948495
Dataset labels: Autophagy-related proteins
Curated region start positions: 28, 28, 28, 28, 28, 28, 25
Curated region end positions: 80, 80, 80, 80, 80, 80, 80
Curated region terms: disorder, flexible linker, disorder, flexible linker, disorder, phosphorylation display site, disorder
Domain/feature annotations: Blc2-like, Apoptosis regulator proteins, Bcl-2 family, Bcl-2 homology region 4
Cross-references: PDB:1LXL, PDB:1R2G, PDB:4HNJ
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Protein: Endoribonuclease toxin MazF
UniProt accession: P0AE70
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW2753, b2782, chpA, chpAK, mazF
Length: 111 residues
Disorder content (fraction disordered): 0.12612612612612611
Dataset labels: Unicellular toxins and antitoxins, RNA-binding proteins
Curated region start positions: 16, 16, 16
Curated region end positions: 29, 29, 29
Curated region terms: disorder, disorder to order, molecular function activator activity
Domain/feature annotations: 2.30.30.110, PemK-like, MazF-like toxin of type II toxin-antitoxin system
Cross-references: PDB:5CK9, PDB:5CKB, PDB:5CO7, PDB:5CQX, PDB:5CQY, PDB:5CR2
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
Protein: Dihydrofolate reductase
UniProt accession: P0ABQ4
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW0047, b0048, folA, tmrA
Length: 159 residues
Disorder content (fraction disordered): 0.27044025157232704
Curated region start positions: 63, 63, 63, 63, 63, 63, 63, 63, 116, 116, 116, 116, 116, 116, 116, 116, 9, 9, 9, 9, 9, 9, 9, 9
Curated region end positions: 72, 72, 72, 72, 72, 72, 72, 72, 132, 132, 132, 132, 132, 132, 132, 132, 24, 24, 24, 24, 24, 24, 24, 24
Curated region terms: disorder, molecular function regulator, disorder to order, protein binding, disorder, molecular function regulator, disorder to order, protein binding, disorder, molecular function regulator, disorder to order, protein binding, disorder, molecular function regulator, disorder to order, protein binding, disorder, molecular function regulator, disorder to order, protein binding, disorder, molecular function regulator, disorder to order, protein binding
Domain/feature annotations: Dihydrofolate Reductase, subunit A, Dihydrofolate Reductase, subunit A, Dihydrofolate reductase
Cross-references: PDB:1RX9
Sequence:
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Protein: RAC-beta serine/threonine-protein kinase
UniProt accession: P31751
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: AKT2
Length: 481 residues
Disorder content (fraction disordered): 0.14345114345114346
Dataset labels: Cancer-related proteins
Curated region start positions: 298, 297, 442, 442, 441, 190, 298, 472
Curated region end positions: 310, 312, 460, 480, 481, 201, 310, 476
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, molecular function activator activity, phosphorylation display site
Domain/feature annotations: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Transferase(Phosphotransferase) domain 1, Phosphorylase Kinase; domain 1, Protein kinase domain, PH domain, Protein kinase C terminal domain
Cross-references: PDB:1GZK, PDB:1GZN, PDB:1GZO, PDB:1MRV, PDB:1MRY
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
Protein: Early activation antigen CD69
UniProt accession: Q07108
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CD69, CLEC2C
Length: 199 residues
Disorder content (fraction disordered): 0.10552763819095476
Curated region start positions: 64
Curated region end positions: 84
Curated region terms: disorder
Domain/feature annotations: Mannose-Binding Protein A, subunit A, Lectin C-type domain
Cross-references: PDB:1FM5
Sequence:
MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK
Protein: Cyclin-H
UniProt accession: P51946
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CCNH
Length: 323 residues
Disorder content (fraction disordered): 0.14241486068111456
Curated region start positions: 288, 1, 288, 1
Curated region end positions: 323, 10, 323, 10
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Cyclin-like, Cyclin-like, Cyclin, N-terminal domain, Cyclin C-terminal domain
Cross-references: PDB:1JKW, PDB:1KXU
Sequence:
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL
Protein: Uroporphyrinogen decarboxylase
UniProt accession: P06132
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: UROD
Length: 367 residues
Disorder content (fraction disordered): 0.027247956403269755
Curated region start positions: 1, 1
Curated region end positions: 10, 10
Curated region terms: disorder, protein binding
Domain/feature annotations: 3.20.20.210, Uroporphyrinogen decarboxylase (URO-D)
Cross-references: PDB:1JPH
Sequence:
MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN
Protein: Epidermal growth factor receptor
UniProt accession: P00533
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: EGFR, ERBB, ERBB1, HER1
Length: 1210 residues
Disorder content (fraction disordered): 0.4487603305785124
Dataset labels: Autophagy-related proteins, Cancer-related proteins
Curated region start positions: 985, 989, 668, 668, 668, 668, 668, 668, 1067, 1170, 668
Curated region end positions: 1012, 1000, 1210, 1210, 1210, 1210, 1210, 1210, 1071, 1174, 1210
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, phosphorylation display site, phosphorylation display site, protein binding
Domain/feature annotations: Receptor L-domain, Receptor L-domain, Immunoglobulin FC, subunit C, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2, Phosphorylase Kinase; domain 1, Transferase(Phosphotransferase) domain 1, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2, Furin-like cysteine rich region, Receptor L domain, Receptor L domain, Protein tyrosine and serine/threonine kinase, Growth factor receptor domain IV, Epidermal growth factor receptor transmembrane-juxtamembrane segment
Cross-references: PDB:1M14, PDB:1M17
Sequence:
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Protein: Eukaryotic peptide chain release factor subunit 1
UniProt accession: P62495
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ERF1, ETF1, RF1, SUP45L1
Length: 437 residues
Disorder content (fraction disordered): 0.15560640732265446
Dataset labels: RNA-binding proteins
Curated region start positions: 333, 358, 423, 414, 329
Curated region end positions: 342, 370, 437, 437, 372
Curated region terms: disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: eRF1 domain 2, 3.30.1330.30, eRF1 domain 1, eRF1 domain 1, eRF1 domain 2, eRF1 domain 3
Cross-references: PDB:1DT9
Sequence:
MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQGMEYQGGDDEFFDLDDY
Protein: Immunoglobulin alpha Fc receptor
UniProt accession: P24071
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CD89, FCAR
Length: 287 residues
Disorder content (fraction disordered): 0.04529616724738676
Curated region start positions: 217
Curated region end positions: 229
Curated region terms: disorder
Domain/feature annotations: Immunoglobulins, Immunoglobulins, Immunoglobulin domain
Cross-references: PDB:1UCT
Sequence:
MDPKQTTLLCLVLCLGQRIQAQEGDFPMPFISAKSSPVIPLDGSVKIQCQAIREAYLTQLMIIKNSTYREIGRRLKFWNETDPEFVIDHMDANKAGRYQCQYRIGHYRFRYSDTLELVVTGLYGKPFLSADRGLVLMPGENISLTCSSAHIPFDRFSLAKEGELSLPQHQSGEHPANFSLGPVDLNVSGIYRCYGWYNRSPYLWSFPSNALELVVTDSIHQDYTTQNLIRMAVAGLVLVALLAILVENWHSHTALNKEASADVAEPSWSQQMCQPGLTFARTPSVCK
Protein: ADP-ribosylation factor-binding protein GGA1
UniProt accession: Q9UJY5
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GGA1
Length: 639 residues
Disorder content (fraction disordered): 0.10954616588419404
Curated region start positions: 166, 144, 303
Curated region end positions: 189, 170, 326
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: 1.25.40.90, 1.20.58.160, 1.20.5.170, 2.60.40.1230, VHS domain, Adaptin C-terminal domain, GAT domain, N-terminal extension of GAT domain
Cross-references: PDB:1NWM, PDB:1OXZ
Sequence:
MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSGPSLDGTGWNSFQSSDATEPPAPALAQAPSMESRPPAQTSLPASSGLDDLDLLGKTLLQQSLPPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGDVDQFPPPETWGSL
Protein: Serine protease HTRA2, mitochondrial
UniProt accession: O43464
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HTRA2, OMI, PRSS25
Length: 458 residues
Disorder content (fraction disordered): 0.0611353711790393
Dataset labels: NDDs-related proteins
Curated region start positions: 344, 280, 344, 344, 344, 345, 345
Curated region end positions: 358, 292, 358, 357, 357, 358, 358
Curated region terms: disorder, disorder, flexible linker, disorder, flexible linker, disorder, flexible linker
Domain/feature annotations: 2.30.42.10, 2.40.10.120, Trypsin-like peptidase domain, PDZ domain
Cross-references: PDB:1LCY, PDB:5FHT, PDB:5M3N
Sequence:
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
Protein: Plasminogen activator inhibitor 1
UniProt accession: P05121
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PAI1, PLANH1, SERPINE1
Length: 402 residues
Disorder content (fraction disordered): 0.03980099502487562
Dataset labels: Extracellular matrix proteins, NDDs-related proteins
Curated region start positions: 355, 361, 355
Curated region end positions: 370, 370, 370
Curated region terms: disorder, disorder, molecular function regulator
Domain/feature annotations: Alpha-1-antitrypsin, domain 1, Antithrombin, subunit I, domain 2, Serpin (serine protease inhibitor)
Cross-references: PDB:1OC0, PDB:3Q02, PDB:3Q03
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Protein: Protein-arginine deiminase type-4
UniProt accession: Q9UM07
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PAD4, PADI4, PADI5, PDI5
Length: 663 residues
Disorder content (fraction disordered): 0.09803921568627452
Curated region start positions: 55, 158, 338, 371, 633
Curated region end positions: 65, 171, 348, 387, 644
Curated region terms: disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: Protein-arginine deiminase, central domain, Protein-arginine deiminase, N-terminal domain, L-arginine/glycine Amidinotransferase; Chain A, Protein-arginine deiminase (PAD), Protein-arginine deiminase (PAD) N-terminal domain, Protein-arginine deiminase (PAD) middle domain
Cross-references: PDB:1WD8
Sequence:
MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHGPPAKKKSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCADITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWNMVP
Protein: Serine/threonine-protein kinase pim-1
UniProt accession: P11309
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PIM1
Length: 313 residues
Disorder content (fraction disordered): 0.05750798722044728
Dataset labels: Cancer-related proteins
Curated region start positions: 14
Curated region end positions: 31
Curated region terms: disorder
Domain/feature annotations: Transferase(Phosphotransferase) domain 1, Phosphorylase Kinase; domain 1, Protein kinase domain
Cross-references: PDB:1XQZ
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
Protein: Nuclear receptor subfamily 1 group I member 2
UniProt accession: O75469
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NR1I2, PXR
Length: 434 residues
Disorder content (fraction disordered): 0.07373271889400922
Curated region start positions: 130, 178
Curated region end positions: 141, 197
Curated region terms: disorder, disorder
Domain/feature annotations: Erythroid Transcription Factor GATA-1, subunit A, Retinoid X Receptor, Ligand-binding domain of nuclear hormone receptor, Double treble clef zinc finger, C4 type
Cross-references: PDB:1ILG
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Protein: Heterogeneous nuclear ribonucleoprotein A1
UniProt accession: P09651
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HNRNPA1, HNRPA1
Length: 372 residues
Disorder content (fraction disordered): 0.1129032258064516
Dataset labels: Condensates-related proteins, RNA-binding proteins
Curated region start positions: 92, 92, 182, 92, 92, 92, 183, 342, 182, 93
Curated region end positions: 102, 102, 196, 102, 102, 102, 190, 357, 186, 97
Curated region terms: disorder, flexible linker, disorder, disorder to order, DNA binding, flexible linker, DNA binding, disorder, ubiquitination display site, phosphorylation display site
Domain/feature annotations: 3.30.70.330, 3.30.70.330, RNA recognition motif, RNA recognition motif, Heterogeneous nuclear ribonucleoprotein A1, LC domain
Cross-references: PDB:1L3K, PDB:2H4M, PDB:2UP1
Sequence:
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
Protein: Protein phosphatase 1 regulatory subunit 1A
UniProt accession: P01099
Organism: Oryctolagus cuniculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Lagomorpha, Leporidae, Oryctolagus
Gene names: IPP1, PPP1R1A
Length: 166 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 166, 166, 166, 166
Curated region terms: disorder, molecular function inhibitor activity, disorder, molecular function inhibitor activity
Domain/feature annotations: Protein phosphatase inhibitor 1/DARPP-32
Sequence:
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEVDEDRIPNPLLKPSLAMSPRQRKKMTRTTPTMKELQMMVEHHLGQQEQGEEPEGAAEGTGAQESQPPGTPGTGAESRLGPSATAQKPAQPSPRAQERRGEEPSTAKTSQDSQGASAV
Protein: Phytanoyl-CoA dioxygenase, peroxisomal
UniProt accession: O14832
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PAHX, PHYH
Length: 338 residues
Disorder content (fraction disordered): 0.1153846153846154
Curated region start positions: 31, 223, 303
Curated region end positions: 42, 233, 318
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: q2cbj1_9rhob like domain, Phytanoyl-CoA dioxygenase (PhyH)
Cross-references: PDB:2A1X
Sequence:
MEQLRAAARLQIVLGHLGRPSAGAVVAHPTSGTISSASFHPQQFQYTLDNNVLTLEQRKFYEENGFLVIKNLVPDADIQRFRNEFEKICRKEVKPLGLTVMRDVTISKSEYAPSEKMITKVQDFQEDKELFRYCTLPEILKYVECFTGPNIMAMHTMLINKPPDSGKKTSRHPLHQDLHYFPFRPSDLIVCAWTAMEHISRNNGCLVVLPGTHKGSLKPHDYPKWEGGVNKMFHGIQDYEENKARVHLVMEKGDTVFFHPLLIHGSGQNKTQGFRKAISCHFASADCHYIDVKGTSQENIEKEVVGIAHKFFGAENSVNLKDIWMFRARLVKGERTNL