LiteFold/DisProt huggingface dataset:
Protein: Calcium-binding protein 4
UniProt accession: Q8VHC5
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Cabp4
Length: 271 residues
Disorder content (fraction disordered): 0.07749077490774908
Curated region start positions: 100
Curated region end positions: 120
Curated region terms: disorder
Domain/feature annotations: EF-hand, EF-hand, EF hand domain, EF-hand domain pair
Sequence:
MATEHNVQLVPGSQKIPKGVVSPRSAAEGPALTRRRSKKESWHPGSQKASSGDQSSSQGSEASGSSKHPPRTKVGQEEPSSAPARPASHRHSHRHRSDPQQDAAQRTYGPLLNRMFGKDRELGPEELEELQAAFEEFDTDQDGYIGYRELGDCMRTLGYMPTEMELLEVSQHVKMRMGGFVDFEEFVELISPKLREETAHMLGVRELRIAFREFDKDRDGRITVAELRQAAPALLGEPLEGTELDEMLREMDLNGDGTIDFDEFVMMLSTG
Protein: Pre-mRNA-splicing factor ISY1
UniProt accession: P21374
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: ISY1, J1657, NTC30, UTR3, YJR050W
Length: 235 residues
Disorder content (fraction disordered): 0.5957446808510638
Curated region start positions: 97, 96
Curated region end positions: 235, 235
Curated region terms: disorder, disorder
Domain/feature annotations: Helix hairpin bin, Isy1-like splicing family
Sequence:
MSRNVDKANSVLVRFQEQQAESAGGYKDYSRYQRPRNVSKVKSIKEANEWKRQVSKEIKQKSTRIYDPSLNEMQIAELNDELNNLFKEWKRWQWHIDHTLMEKKTKRKRLEDSHVLMNSGKLINGKRYFGRALELPEVKEWLKQSQRQNDGGSINTKCIPKDRNDFYYHGKVTAALTEFEANWTSILKAHYNVPVNEDEEEMSRQTQEIHVPTLADMEHWLVQRRKKKLMDELNL
Protein: Ribonuclease H2 subunit B
UniProt accession: Q80ZV0
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Dleu8, Rnaseh2b
Length: 308 residues
Disorder content (fraction disordered): 0.5
Curated region start positions: 103, 107, 182, 283, 182
Curated region end positions: 145, 122, 202, 308, 266
Curated region terms: disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: 1.10.20.120, 2.20.25.530, Ydr279p protein family (RNase H2 complex component) wHTH domain, Ydr279p protein triple barrel domain
Sequence:
MAGGRDRGDLAARQLVFLLPEHLKDASKKKKKSSLLFVKLANPHSGEGATYLIDMCLQQLFEIKVFKEKHHSWFINQSVQSGGLLHFATPMDPLFLLLHYLLKAGKEGKYQPLDQVVVDDTFPDCTLLLRFPELEKSLRHVTEEKEVNSKKYYKYSSEKTLKWLEKKVNQTVVALKANNVNVGARVQSSAYFSGGQVSRDKEEDYVRYAHGLISDYIPKELSDDLSKFLKLPEPPASLTNPPSKKLKLSDEPVEAKEDYTKFNTKDLKTGKKNSKMTAAQKALAKVDKSGMKSIDAFFGAKNKKTGKI
Protein: Pancreas/duodenum homeobox protein 1
UniProt accession: P52945
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: IPF1, PDX1, STF1
Length: 283 residues
Disorder content (fraction disordered): 0.2826855123674912
Curated region start positions: 204
Curated region end positions: 283
Curated region terms: disorder
Domain/feature annotations: Homeodomain-like, Homeodomain
Sequence:
MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR
Protein: Vacuolar protein-sorting-associated protein 25
UniProt accession: Q9BRG1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DERP9, EAP20, VPS25
Length: 176 residues
Disorder content (fraction disordered): 0.07386363636363637
Curated region start positions: 133
Curated region end positions: 145
Curated region terms: disorder
Domain/feature annotations: "Winged helix" DNA-binding domain. Chain C. Domain 1, Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, ESCRT-II complex subunit
Sequence:
MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF
Protein: Vacuolar protein-sorting-associated protein 25
UniProt accession: P47142
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: J1957, VPS25, VPT25, YJR102C
Length: 202 residues
Disorder content (fraction disordered): 0.0891089108910891
Curated region start positions: 55, 56, 56
Curated region end positions: 71, 70, 72
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, "Winged helix" DNA-binding domain. Chain C. Domain 1, ESCRT-II complex subunit
Cross-references: PDB:1XB4
Sequence:
MSALPPVYSFPPLYTRQPNSLTRRQQISTWIDIISQYCKTKKIWYMSVDGTVINDNELDSGSTDNDDSKKISKNLFNNEDIQRSVSQVFIDEIWSQMTKEGKCLPIDQSGRRSSNTTTTRYFILWKSLDSWASLILQWFEDSGKLNQVITLYELSEGDETVNWEFHRMPESLLYYCLKPLCDRNRATMLKDENDKVIAIKVV
Protein: Regulatory protein YscM2
UniProt accession: Q93KQ4
Organism: Yersinia enterocolitica
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Yersiniaceae, Yersinia
Gene names: yscM2
Length: 116 residues
Disorder content (fraction disordered): 0.2672413793103448
Dataset labels: Bacterial virulence-related proteins
Curated region start positions: 51
Curated region end positions: 81
Curated region terms: disorder
Domain/feature annotations: Protein-tyrosine phosphatase, YopH, N-terminal domain, YopH, N-terminal
Cross-references: PDB:1TTW
Sequence:
MGSIMKINDLKSLISMQIAEFGGGEKIGRLKSTLQQVSTQAITSDERRFAYAVLEHAKNTILNRQDVAKLLPRASNFELSQGKKGEVILKGLRVEQLSLEDAKLLLDAVTRKMQKL
Protein: Polypyrimidine tract-binding protein 1
UniProt accession: P26599
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PTB, PTBP1
Length: 557 residues
Disorder content (fraction disordered): 0.1490125673249551
Dataset labels: Condensates-related proteins, RNA-binding proteins, Cancer-related proteins
Curated region start positions: 409, 431, 431, 143, 143
Curated region end positions: 425, 454, 454, 184, 184
Curated region terms: disorder, disorder, flexible linker, disorder, flexible linker
Domain/feature annotations: 3.30.70.330, 3.30.70.330, 3.30.70.330, 3.30.70.330, RRM-like domain, RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), RRM domain
Cross-references: BMRB:5409, PDB:1QM9
Sequence:
MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGAPGIISASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGNQAQLAMSHLNGHKLHGKPIRITLSKHQNVQLPREGQEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNHDLGENHHLRVSFSKSTI
Protein: Stimulator of interferon genes protein
UniProt accession: Q86WV6
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ERIS, MITA, STING, STING1, TMEM173
Length: 379 residues
Disorder content (fraction disordered): 0.10026385224274406
Dataset labels: Condensates-related proteins
Curated region start positions: 342, 359, 358, 344, 344, 342, 358
Curated region end positions: 379, 379, 379, 379, 379, 379, 366
Curated region terms: disorder, protein binding, phosphorylation display site, disorder, disorder, protein binding, protein binding
Domain/feature annotations: Stimulator of interferon genes protein, STING ligand-binding domain, STING transmembrane domain
Cross-references: PDB:4EF4, PDB:4EF5, PDB:4F5W, PDB:4F5Y, PDB:5JEJ
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
Protein: PRKC apoptosis WT1 regulator protein
UniProt accession: Q96IZ0
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PAR4, PAWR
Length: 340 residues
Disorder content (fraction disordered): 0.06764705882352941
Curated region start positions: 59, 62, 62, 62, 62
Curated region end positions: 77, 81, 81, 77, 77
Curated region terms: disorder, disorder, protein binding, disorder, protein binding
Cross-references: PDB:2jk9
Sequence:
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
Protein: Protein RIF2
UniProt accession: Q06208
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: RIF2, YLR453C
Length: 395 residues
Disorder content (fraction disordered): 0.1189873417721519
Curated region start positions: 152, 49
Curated region end positions: 186, 60
Curated region terms: disorder, disorder
Domain/feature annotations: RIF2, ASCE domain, RIF2, AAA+ lid domain
Cross-references: PDB:4bj1, PDB:4bj6
Sequence:
MEHVDSDFAPIRRSKKVVDSDKIVKAISDDLEQKNFTVLRKLNLVPIKKSVSSPKVCKPSPVKERVDHVFYQKFKSMALQELGTNYLSISYVPSLSKFLSKNLRSMKNCIVFFDKVEHIHQYAGIDRAVSETLSLVDINVVIIEMNDYLMKEGIQSSKSKECIESMGQASYSGQLDFEASEKPSNHTSDLMMMVMRKINNDESIDHIVYFKFEQLDKLSTSTIIEPSKLTEFINVLSVLEKSNNIAFKVLIYSNNVSISSLLSTSLKKKLNTKYTVFEMPILTCAQEQEYLKKMIKFTFDSGSKLLQSYNSLVTCQLNNKESNLAIFFEFLKVFPHPFTYLFNAYTEIIVQSRTFDELLDKIRNRLTIKNYPHSAYNFKKNQRLPLKLTRKVHDR
Protein: Telomere length regulator protein RIF1
UniProt accession: P29539
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: RIF1, YBR1743, YBR275C
Length: 1916 residues
Disorder content (fraction disordered): 0.04384133611691023
Curated region start positions: 1773
Curated region end positions: 1856
Curated region terms: disorder
Domain/feature annotations: Rap1-interacting factor 1 N terminal
Sequence:
MSKDFSDKKKHTIDRIDQHILRRSQHDNYSNGSSPWMKTNLPPPSPQAHMHIQSDLSPTPKRRKLASSSDCENKQFDLSAINKNLYPEDTGSRLMQSLPELSASNSDNVSPVTKSVAFSDRIESSPIYRIPGSSPKPSPSSKPGKSILRNRLPSVRTVSDLSYNKLQYTQHKLHNGNIFTSPYKETRVNPRALEYWVSGEIHGLVDNESVSEFKEIIEGGLGILRQESEDYVARRFEVYATFNNIIPILTTKNVNEVDQKFNILIVNIESIIEICIPHLQIAQDTLLSSSEKKNPFVIRLYVQIVRFFSAIMSNFKIVKWLTKRPDLVNKLKVIYRWTTGALRNENSNKIIITAQVSFLRDEKFGTFFLSNEEIKPIISTFTEIMEINSHNLIYEKLLLIRGFLSKYPKLMIETVTSWLPGEVLPRIIIGDEIYSMKILITSIVVLLELLKKCLDFVDEHERIYQCIMLSPVCETIPEKFLSKLPLNSYDSANLDKVTIGHLLTQQIKNYIVVKNDNKIAMDLWLSMTGLLYDSGKRVYDLTSESNKVWFDLNNLCFINNHPKTRLMSIKVWRIITYCICTKISQKNQEGNKSLLSLLRTPFQMTLPYVNDPSAREGIIYHLLGVVYTAFTSNKNLSTDMFELFWDHLITPIYEDYVFKYDSIHLQNVLFTVLHLLIGGKNADVALERKYKKHIHPMSVIASEGVKLKDISSLPPQIIKREYDKIMKVVFQAVEVAISNVNLAHDLILTSLKHLPEDRKDQTHLESFSSLILKVTQNNKDTPIFRDFFGAVTSSFVYTFLDLFLRKNDSSLVNFNIQISKVGISQGNMTLDLLKDVIRKARNETSEFLIIEKFLELDDKKTEVYAQNWVGSTLLPPNISFREFQSLANIVNKVPNENSIENFLDLCLKLSFPVNLFTLLHVSMWSNNNFIYFIQSYVSKNENKLNVDLITLLKTSLPGNPELFSGLLPFLRRNKFMDILEYCIHSNPNLLNSIPDLNSDLLLKLLPRSRASYFAANIKLFKCSEQLTLVRWLLKGQQLEQLNQNFSEIENVLQNASDSELEKSEIIRELLHLAMANPIEPLFSGLLNFCIKNNMADHLDEFCGNMTSEVLFKISPELLLKLLTYKEKPNGKLLAAVIEKIENGDDDYILELLEKIIIQKEIQILEKLKEPLLVFFLNPVSSNMQKHKKSTNMLRELVLLYLTKPLSRSAAKKFFSMLISILPPNPNYQTIDMVNLLIDLIKSHNRKFKDKRTYNATLKTIGKWIQESGVVHQGDSSKEIEAIPDTKSMYIPCEGSENKLSNLQRKVDSQDIQVPATQGMKEPPSSIQISSQISAKDSDSISLKNTAIMNSSQQESHANRSRSIDDETLEEVDNESIREIDQQMKSTQLDKNVANHSNICSTKSDEVDVTELHESIDTQSSEVNAYQPIEVLTSELKAVTNRSIKTNPDHNVVNSDNPLKRPSKETPTSENKRSKGHETMVDVLVSEEQAVSPSSDVICTNIKSIANEESSLALRNSIKVETNCNENSLNVTLDLDQQTITKEDGKGQVEHVQRQENQESMNKINSKSFTQDNIAQYKSVKKARPNNEGENNDYACNVEQASPVRNEVPGDGIQIPSGTILLNSSKQTEKSKVDDLRSDEDEHGTVAQEKHQVGAINSRNKNNDRMDSTPIQGTEEESREVVMTEEGINVRLEDSGTCELNKNLKGPLKGDKDANINDDFVPVEENVRDEGFLKSMEHAVSKETGLEEQPEVADISVLPEIRIPIFNSLKMQGSKSQIKEKLKKRLQRNELMPPDSPPRMTENTNINAQNGLDTVPKTIGGKEKHHEIQLGQAHTEADGEPLLGGDGNEDATSREATPSLKVHFFSKKSRRLVARLRGFTPGDLNGISVEERRNLRIELLDFMMRLEYYSNRDNDMN
Protein: Potassium voltage-gated channel subfamily E member 3
UniProt accession: Q9Y6H6
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: KCNE3
Length: 103 residues
Disorder content (fraction disordered): 0.34951456310679613
Curated region start positions: 1, 31
Curated region end positions: 10, 56
Curated region terms: disorder, disorder
Domain/feature annotations: Slow voltage-gated potassium channel
Sequence:
METTNGTETWYESLHAVLKALNATLHSNLLCRPGPGLGPDNQTEERRASLPGRDDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
Protein: Vacuolar protein-sorting-associated protein 36
UniProt accession: Q06696
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: GRD12, VAC3, VPL11, VPS36, YLR417W
Length: 566 residues
Disorder content (fraction disordered): 0.6978798586572438
Curated region start positions: 203, 1, 1, 203, 177, 177
Curated region end positions: 395, 395, 395, 395, 205, 205
Curated region terms: disorder, disorder, disorder, flexible linker, localization, protein binding
Domain/feature annotations: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), EAP30/Vps36 family, Vacuolar protein sorting protein 36 Vps36, Vacuolar protein sorting 36 NZF-N zinc-finger domain
Cross-references: PDB:1U5T, PDB:1W7P
Sequence:
MEYWHYVETTSSGQPLLREGEKDIFIDQSVGLYHGKSKILQRQRGRIFLTSQRIIYIDDAKPTQNSLGLELDDLAYVNYSSGFLTRSPRLILFFKDPSSKDELGKSAETASADVVSTWVCPICMVSNETQGEFTKDTLPTPICINCGVPADYELTKSSINCSNAIDPNANPQNQFGVNSENICPACTFANHPQIGNCEICGHRLPNASKVRSKLNRLNFHDSRVHIELEKNSLARNKSSHSALSSSSSTGSSTEFVQLSFRKSDGVLFSQATERALENILTEKNKHIFNQNVVSVNGVDMRKGASSHEYNNEVPFIETKLSRIGISSLEKSRENQLLNNDILFNNALTDLNKLMSLATSIERLYKNSNITMKTKTLNLQDESTVNEPKTRRPLLILDREKFLNKELFLDEIAREIYEFTLSEFKDLNSDTNYMIITLVDLYAMYNKSMRIGTGLISPMEMREACERFEHLGLNELKLVKVNKRILCVTSEKFDVVKEKLVDLIGDNPGSDLLRLTQILSSNNSKSNWTLGILMEVLQNCVDEGDLLIDKQLSGIYYYKNSYWPSHI
Protein: Beclin-1
UniProt accession: O88597
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Becn1
Length: 448 residues
Disorder content (fraction disordered): 0.060267857142857144
Curated region start positions: 124
Curated region end positions: 150
Curated region terms: disorder
Domain/feature annotations: Autophagy protein 6/Beclin 1, Apg6 BARA domain, Beclin-1 BH3 domain, Bcl-2-interacting, Apg6 coiled-coil region
Cross-references: PDB:3bl2
Sequence:
MEGSKASSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEEANSGEEPFIETRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
Protein: Fermitin family homolog 2
UniProt accession: Q96AC1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FERMT2, KIND2, MIG2, PLEKHC1
Length: 680 residues
Disorder content (fraction disordered): 0.09705882352941177
Curated region start positions: 328, 350, 1, 95, 350
Curated region end positions: 367, 357, 15, 105, 357
Curated region terms: disorder, protein binding, disorder, disorder, protein binding
Domain/feature annotations: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1, FERM central domain, FERM central domain, Kindlin-2 N-terminal domain
Cross-references: BMRB:17827, PDB:2LGX
Sequence:
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV
Protein: Interferon regulatory factor 3
UniProt accession: Q14653
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: IRF3
Length: 427 residues
Disorder content (fraction disordered): 0.03747072599531616
Curated region start positions: 173
Curated region end positions: 188
Curated region terms: disorder
Domain/feature annotations: 2.60.200.10, Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, Interferon regulatory factor transcription factor, Interferon-regulatory factor 3
Cross-references: PDB:1QWT
Sequence:
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES
Protein: Protein E6
UniProt accession: P03126
Organism: Human papillomavirus type 16
Taxonomy: Viruses, Monodnaviria, Shotokuvirae, Cossaviricota, Papovaviricetes, Zurhausenvirales, Papillomaviridae, Firstpapillomavirinae, Alphapapillomavirus
Gene names: E6
Length: 158 residues
Disorder content (fraction disordered): 0.13291139240506328
Dataset labels: Viral proteins
Curated region start positions: 1, 148, 148, 148, 148, 148, 148, 148, 148, 1
Curated region end positions: 10, 158, 158, 158, 158, 158, 158, 158, 158, 10
Curated region terms: disorder, disorder, flexible C-terminal tail, protein binding, protein binding, regulation of proteolysis, protein binding, regulation of proteolysis, regulation of proteolysis, flexible N-terminal tail
Domain/feature annotations: E6 early regulatory protein, E6 early regulatory protein, Early Protein (E6)
Cross-references: BMRB:17967, BMRB:17968, BMRB:6707, PDB:2FK4, PDB:2LJX, PDB:2LJY, PDB:6HKS
Sequence:
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
Protein: Large T antigen
UniProt accession: P03070
Organism: Simian virus 40
Taxonomy: Viruses, Monodnaviria, Shotokuvirae, Cossaviricota, Papovaviricetes, Sepolyvirales, Polyomaviridae, Betapolyomavirus
Length: 708 residues
Disorder content (fraction disordered): 0.1172316384180791
Dataset labels: Viral proteins
Curated region start positions: 17, 39, 39, 82, 68, 103, 103
Curated region end positions: 26, 48, 48, 130, 87, 117, 117
Curated region terms: disorder, disorder, protein binding, disorder, disorder, disorder, protein binding
Domain/feature annotations: DnaJ domain, 3.40.1310.20, Large T antigen, SV40, domain 3, P-loop containing nucleotide triphosphate hydrolases, Zinc finger, large T-antigen D1 domain, Origin of replication binding protein, Polyomavirus large T antigen C-terminus
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
Protein: Diablo homolog, mitochondrial
UniProt accession: Q9NR28
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DIABLO, SMAC
Length: 239 residues
Disorder content (fraction disordered): 0.06276150627615062
Curated region start positions: 56, 56, 56, 56, 56
Curated region end positions: 69, 67, 70, 70, 65
Curated region terms: disorder, disorder, disorder, protein binding, disorder
Domain/feature annotations: 1.20.58.70, Second Mitochondria-derived Activator of Caspases
Sequence:
MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTIGFGVTLCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRED
Protein: Hepatocyte nuclear factor 1-alpha
UniProt accession: P20823
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HNF1A, TCF1
Length: 631 residues
Disorder content (fraction disordered): 0.03169572107765452
Dataset labels: Cancer-related proteins
Curated region start positions: 181, 181
Curated region end positions: 200, 200
Curated region terms: disorder, flexible linker
Domain/feature annotations: Homeodomain-like, lambda repressor-like DNA-binding domains, Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus, Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus, Hepatocyte nuclear factor 1 (HNF-1), N terminus
Cross-references: PDB:1IC8
Sequence:
MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAELPNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSHSLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTKQVFTSDTEASSESGLHTPASQATTLHVPSQDPASIQHLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETFISTQMASSSQ