LiteFold/DisProt huggingface dataset:
Protein: Isoform Tau-F of Microtubule-associated protein tau
UniProt accession: P10636-8
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MAPT, MAPTL, MTBT1, TAU
Length: 441 residues
Disorder content (fraction disordered): 1
Dataset labels: Condensates-related proteins
Curated region start positions: 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
Curated region end positions: 441, 441, 441, 441, 441, 441, 441, 441, 441, 441, 441, 441, 441, 441, 441
Curated region terms: disorder, disorder, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, disorder, disorder, disorder, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, disorder, disorder
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Protein: RNA-binding protein FUS
UniProt accession: P35637
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FUS, TLS
Length: 526 residues
Disorder content (fraction disordered): 0.9638783269961976
Dataset labels: Condensates-related proteins, Cancer-related proteins, RNA-binding proteins, Age-related disorders proteins
Curated region start positions: 1, 508, 37, 149, 1, 1, 285, 285, 421, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 98, 39, 1, 305, 1, 1, 221, 221, 221, 221, 1, 221, 1, 221
Curated region end positions: 507, 526, 41, 154, 163, 526, 370, 370, 455, 526, 163, 163, 526, 163, 526, 214, 214, 214, 526, 526, 422, 526, 526, 526, 36, 214, 95, 211, 368, 526, 526, 526, 526, 526, 526, 526, 526, 211, 526
Curated region terms: disorder, protein binding, protein binding, protein binding, intracellular non-membrane-bounded organelle, molecular condensate scaffold activity, RNA binding, disorder to order, disorder to order, molecular condensate scaffold activity, disorder, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, intracellular non-membrane-bounded organelle, intracellular non-membrane-bounded organelle, amyloid fibril formation, intracellular non-membrane-bounded organelle, intracellular non-membrane-bounded organelle, intracellular non-membrane-bounded organelle, intracellular non-membrane-bounded organelle, intracellular non-membrane-bounded organelle, molecular condensate scaffold activity, molecular condensate scaffold activity, disorder, disorder, amyloid fibril formation, RNA binding, molecular condensate scaffold activity, nucleoplasm, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, RNA binding, RNA binding, RNA binding, RNA binding, non-membrane-bounded organelle assembly
Domain/feature annotations: 3.30.70.330, Zinc finger, RanBP2-type, RNA recognition motif, Zn-finger in Ran binding protein and others
Cross-references: PDB:5W3N, PDB:5YVG, PDB:5YVH, PDB:5YVI
Sequence:
MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY
Protein: Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt accession: Q13698
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CACH1, CACN1, CACNA1S, CACNL1A3
Length: 1873 residues
Disorder content (fraction disordered): 0.06780565936999466
Curated region start positions: 665, 665, 665, 665, 665, 665, 666, 666, 666
Curated region end positions: 785, 785, 785, 785, 785, 785, 791, 791, 791
Curated region terms: disorder, molecular function activator activity, small molecule binding, disorder, molecular function activator activity, small molecule binding, disorder, molecular function activator activity, small molecule binding
Domain/feature annotations: Voltage-gated potassium channels. Chain C, Voltage-gated potassium channels. Chain C, Voltage-gated potassium channels. Chain C, Voltage-gated potassium channels. Chain C, 1.10.287.70, 1.10.287.70, 1.10.287.70, EF-hand, Ion transport protein, Ion transport protein, Ion transport protein, Ion transport protein, Voltage gated calcium channel IQ domain, Voltage-dependent L-type calcium channel, IQ-associated
Sequence:
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHVFSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAPCQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQHQGSQETLIPPRL
Protein: Protein kinase C alpha type
UniProt accession: P20444
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Pkca, Prkca
Length: 672 residues
Disorder content (fraction disordered): 0.09970238095238096
Curated region start positions: 606, 606, 606, 606, 606, 606, 606
Curated region end positions: 672, 672, 672, 672, 672, 672, 672
Curated region terms: disorder, limited proteolysis display site, lipid binding, disorder, limited proteolysis display site, disorder to order, lipid binding
Domain/feature annotations: C2 domain, 3.30.60.20, Transferase(Phosphotransferase) domain 1, 3.30.60.20, Phosphorylase Kinase; domain 1, Phosphorylase Kinase; domain 1, Protein kinase domain, Phorbol esters/diacylglycerol binding domain (C1 domain), Phorbol esters/diacylglycerol binding domain (C1 domain), C2 domain, Protein kinase C terminal domain
Sequence:
MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKAHNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPVGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
Protein: Prolactin receptor
UniProt accession: P16471
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PRLR
Length: 622 residues
Disorder content (fraction disordered): 0.5836012861736335
Curated region start positions: 236, 236, 236, 236, 236, 236, 350, 547, 281
Curated region end positions: 598, 598, 598, 396, 396, 300, 383, 598, 285
Curated region terms: disorder, disorder, disorder, disorder, lipid binding, lipid binding, lipid binding, lipid binding, phosphorylation display site
Domain/feature annotations: Immunoglobulins, Immunoglobulins, Erythropoietin receptor, ligand binding
Sequence:
MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH
Protein: TAR DNA-binding protein 43
UniProt accession: Q13148
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TARDBP, TDP43
Length: 414 residues
Disorder content (fraction disordered): 0.3671497584541063
Dataset labels: Condensates-related proteins, RNA-binding proteins
Curated region start positions: 266, 266, 266, 267, 267, 267, 267, 321, 266, 266, 266, 263, 263, 263, 263, 263, 263, 263, 263, 263, 263, 263, 263, 263
Curated region end positions: 414, 414, 414, 414, 414, 414, 414, 343, 414, 414, 414, 414, 414, 414, 414, 414, 414, 414, 414, 414, 414, 414, 414, 414
Curated region terms: disorder, molecular condensate scaffold activity, molecular condensate scaffold activity, disorder, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, intracellular non-membrane-bounded organelle, disorder, disorder, intracellular non-membrane-bounded organelle, intracellular non-membrane-bounded organelle, amyloid fibril formation, amyloid fibril formation, intracellular non-membrane-bounded organelle, disorder to order, DNA binding, DNA binding, disorder to order, lipid binding, lipid binding
Domain/feature annotations: 3.30.70.330, 3.30.70.330, RNA recognition motif, RNA recognition motif, TAR DNA-binding protein 43, N-terminal domain, TAR DNA-binding protein 43, C-terminal
Cross-references: PDB:2N2C
Sequence:
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
Protein: Heterogeneous nuclear ribonucleoproteins A2/B1
UniProt accession: P22626
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HNRNPA2B1, HNRPA2B1
Length: 353 residues
Disorder content (fraction disordered): 0.4305949008498583
Dataset labels: Condensates-related proteins, Cancer-related proteins, RNA-binding proteins
Curated region start positions: 190, 190, 190, 190
Curated region end positions: 341, 341, 341, 341
Curated region terms: disorder, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity
Domain/feature annotations: 3.30.70.330, 3.30.70.330, RNA recognition motif, RNA recognition motif, Heterogeneous nuclear ribonucleoprotein A1, LC domain
Sequence:
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
Protein: Ubiquilin-2
UniProt accession: Q9UHD9
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HRIHFB2157, N4BP4, PLIC2, UBQLN2
Length: 624 residues
Disorder content (fraction disordered): 0.20352564102564105
Dataset labels: Condensates-related proteins
Curated region start positions: 450, 450
Curated region end positions: 576, 576
Curated region terms: disorder, molecular condensate scaffold activity
Domain/feature annotations: 1.10.260.100, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1, 1.10.260.100, DNA helicase RuvA subunit, C-terminal domain, Ubiquitin family, UBA/TS-N domain, Ubiquilin-1-like domain
Sequence:
MAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPISTNSNPFGLGSLGGLAGLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQSSATTSTTTSTGSGSGNSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAAQMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGGPTGPTVSSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS
Protein: Sequestosome-1
UniProt accession: Q13501
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ORCA, OSIL, SQSTM1
Length: 440 residues
Disorder content (fraction disordered): 0.10454545454545454
Dataset labels: Autophagy-related proteins, NDDs-related proteins, Condensates-related proteins, Age-related disorders proteins
Curated region start positions: 341, 341
Curated region end positions: 386, 386
Curated region terms: disorder, disorder
Domain/feature annotations: 3.30.60.90, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1, DNA helicase RuvA subunit, C-terminal domain, PB1 domain, Zinc finger, ZZ type, UBA domain
Sequence:
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
Protein: Phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt accession: P27986
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GRB1, PIK3R1
Length: 724 residues
Disorder content (fraction disordered): 0.019337016574585635
Dataset labels: Cancer-related proteins, NDDs-related proteins
Curated region start positions: 91, 91, 91, 91, 91
Curated region end positions: 104, 104, 104, 104, 104
Curated region terms: disorder, protein binding, disorder, protein binding, protein binding
Domain/feature annotations: Rho GTPase activation protein, SH2 domain, SH2 domain, SH3 Domains, SH2 domain, SH2 domain, RhoGAP domain, Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Cross-references: PDB:1A0N, PDB:1AZG
Sequence:
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
Protein: ATP-dependent RNA helicase laf-1
UniProt accession: D0PV95
Organism: Caenorhabditis elegans
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Nematoda, Chromadorea, Rhabditida, Rhabditina, Rhabditomorpha, Rhabditoidea, Rhabditidae, Peloderinae, Caenorhabditis
Gene names: Y71H2AM.19, laf-1
Length: 708 residues
Disorder content (fraction disordered): 0.23728813559322037
Dataset labels: Condensates-related proteins, RNA-binding proteins
Curated region start positions: 1, 1, 1
Curated region end positions: 168, 168, 168
Curated region terms: disorder, molecular condensate scaffold activity, RNA binding
Domain/feature annotations: P-loop containing nucleotide triphosphate hydrolases, P-loop containing nucleotide triphosphate hydrolases, DEAD/DEAH box helicase, Helicase conserved C-terminal domain
Sequence:
MESNQSNNGGSGNAALNRGGRYVPPHLRGGDGGAAAAASAGGDDRRGGAGGGGYRRGGGNSGGGGGGGYDRGYNDNRDDRDNRGGSGGYGRDRNYEDRGYNGGGGGGGNRGYNNNRGGGGGGYNRQDRGDGGSSNFSRGGYNNRDEGSDNRGSGRSYNNDRRDNGGDGQNTRWNNLDAPPSRGTSKWENRGARDERIEQELFSGQLSGINFDKYEEIPVEATGDDVPQPISLFSDLSLHEWIEENIKTAGYDRPTPVQKYSIPALQGGRDLMSCAQTGSGKTAAFLVPLVNAILQDGPDAVHRSVTSSGGRKKQYPSALVLSPTRELSLQIFNESRKFAYRTPITSALLYGGRENYKDQIHKLRLGCHILIATPGRLIDVMDQGLIGMEGCRYLVLDEADRMLDMGFEPQIRQIVECNRMPSKEERITAMFSATFPKEIQLLAQDFLKENYVFLAVGRVGSTSENIMQKIVWVEEDEKRSYLMDLLDATGDSSLTLVFVETKRGASDLAYYLNRQNYEVVTIHGDLKQFEREKHLDLFRTGTAPILVATAVAARGLDIPNVKHVINYDLPSDVDEYVHRIGRTGRVGNVGLATSFFNDKNRNIARELMDLIVEANQELPDWLEGMSGDMRSGGGYRGRGGRGNGQRFGGRDHRYQGGSGNGGGGNGGGGGFGGGGQRSGGGGGFQSGGGGGRQQQQQQRAQPQQDWWS
Protein: Cytoplasmic protein NCK1
UniProt accession: P16333
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NCK, NCK1
Length: 377 residues
Disorder content (fraction disordered): 0.13262599469496025
Dataset labels: Condensates-related proteins
Curated region start positions: 59, 59
Curated region end positions: 108, 108
Curated region terms: disorder, molecular condensate scaffold activity
Domain/feature annotations: SH2 domain, SH3 Domains, SH3 Domains, SH3 Domains, SH2 domain, SH3 domain, SH3 domain, SH3 domain
Sequence:
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
Protein: Nuclear factor erythroid 2-related factor 2
UniProt accession: Q16236
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NFE2L2, NRF2
Length: 605 residues
Disorder content (fraction disordered): 1
Dataset labels: Autophagy-related proteins, Cancer-related proteins, Condensates-related proteins
Curated region start positions: 69, 1, 1, 1, 1, 17, 17, 76, 76, 17, 74, 1, 1, 1, 209, 209, 1, 1, 1, 1
Curated region end positions: 84, 605, 605, 605, 605, 46, 46, 84, 84, 46, 87, 56, 605, 208, 605, 605, 208, 208, 605, 605
Curated region terms: protein binding, pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule to order, protein binding, protein binding, regulation of cellular response to oxidative stress, regulation of cellular response to oxidative stress, ubiquitin protein ligase binding, ubiquitin protein ligase binding, non-membrane-bounded organelle, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, positive regulation of transcription, DNA-templated, mediator complex, non-membrane-bounded organelle
Domain/feature annotations: Transcription factor, Skn-1-like, DNA-binding domain, bZIP Maf transcription factor
Cross-references: ELM:DEG_Kelch_Keap1_1, PDB:2FLU
Sequence:
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN
Protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
UniProt accession: O60566
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BUB1B, BUBR1, MAD3L, SSK1
Length: 1050 residues
Disorder content (fraction disordered): 0.021904761904761903
Dataset labels: Cancer-related proteins, NDDs-related proteins
Curated region start positions: 20, 20, 20
Curated region end positions: 42, 42, 42
Curated region terms: disorder, protein binding, protein binding
Domain/feature annotations: Transferase(Phosphotransferase) domain 1, 1.25.40.430, Mad3/BUB1 homology region 1
Cross-references: ELM:DEG_APCC_KENBOX_2, ELM:ELMI002601, PDB:4GGD
Sequence:
MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSHLNKALWKVGKLTSPGALLFQ