LiteFold/DisProt huggingface dataset:
Protein: Phosphoprotein
UniProt accession: Q9IK91
Organism: Nipah virus
Taxonomy: Viruses, Riboviria, Orthornavirae, Negarnaviricota, Haploviricotina, Monjiviricetes, Mononegavirales, Paramyxoviridae, Orthoparamyxovirinae, Henipavirus
Gene names: P/V/C
Length: 709 residues
Disorder content (fraction disordered): 0.5726375176304654
Dataset labels: Viral proteins
Curated region start positions: 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
Curated region end positions: 406, 406, 406, 406, 406, 406, 406, 406, 100, 100, 100, 35, 35, 50, 50, 50, 50, 35, 100
Curated region terms: pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, disorder, disorder, disorder, disorder, disorder, protein binding, disorder to order, protein binding, protein binding, molecular adaptor activity, molecular adaptor activity, molecular adaptor activity, disorder to order
Domain/feature annotations: DNA helicase RuvA subunit, C-terminal domain, Paramyxovirus P/V phosphoprotein C-terminal, Paramyxovirus structural protein V/P N-terminus, N-terminal region of Paramyxovirinae phosphoprotein (P), Phosphoprotein P region PNT disordered
Cross-references: BMRB:50370, PDB:4CO6, SASBDB:SASDJB5
Sequence:
MDKLELVNDGLNIIDFIQKNQKEIQKTYGRSSIQQPSIKDQTKAWEDFLQCTSGESEQVEGGMSKDDGDVERRNLEDLSSTSPTDGTIGKRVSNTRDWAEGSDDIQLDPVVTDVVYHDHGGECTGYGFTSSPERGWSDYTSGANNGNVCLVSDAKMLSYAPEIAVSKEDRETDLVHLENKLSTTGLNPTAVPFTLRNLSDPAKDSPVIAEHYYGLGVKEQNVGPQTSRNVNLDSIKLYTSDDEEADQLEFEDEFAGSSSEVIVGISPEDEEPSSVGGKPNESIGRTIEGQSIRDNLQAKDNKSTDVPGAGPKDSAVKEEPPQKRLPMLAEEFECSGSEDPIIRELLKENSLINCQQGKDAQPPYHWSIERSISPDKTEIVNGAVQTADRQRPGTPMPKSRGIPIKKGTDAKYPSAGTENVPGSKSGATRHVRGSPPYQEGKSVNAENVQLNASTAVKETDKSEVNPVDDNDSLDDKYIMPSDDFSNTFFPHDTDRLNYHADHLGDYDLETLCEESVLMGVINSIKLINLDMRLNHIEEQVKEIPKIINKLESIDRVLAKTNTALSTIEGHLVSMMIMIPGKGKGERKGKNNPELKPVIGRDILEQQSLFSFDNVKNFRDGSLTNEPYGAAVQLREDLILPELNFEETNASQFVPMADDSSRDVIKTLIRTHIKDRELRSELIGYLNKAENDEEIQEIANTVNDIIDGNI
Protein: Phosphoprotein
UniProt accession: O55778
Organism: Hendra virus (isolate Horse/Autralia/Hendra/1994)
Taxonomy: Viruses, Riboviria, Orthornavirae, Negarnaviricota, Haploviricotina, Monjiviricetes, Mononegavirales, Paramyxoviridae, Orthoparamyxovirinae, Henipavirus
Gene names: P/V/C
Length: 707 residues
Disorder content (fraction disordered): 0.5742574257425742
Dataset labels: Viral proteins, Condensates-related proteins
Curated region start positions: 1, 1, 1, 1, 1, 1, 200, 200, 200, 200, 200, 200, 300, 300, 300
Curated region end positions: 404, 404, 404, 404, 404, 404, 310, 310, 310, 310, 310, 310, 406, 406, 406
Curated region terms: pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, disorder, disorder, amyloid fibril formation, disorder, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, disorder, disorder, disorder
Domain/feature annotations: DNA helicase RuvA subunit, C-terminal domain, Paramyxovirus P/V phosphoprotein C-terminal, Paramyxovirus structural protein V/P N-terminus, N-terminal region of Paramyxovirinae phosphoprotein (P), Phosphoprotein P region PNT disordered
Sequence:
MDKLDLVNDGLDIIDFIQKNQKEIQKTYGRSSIQQPSTKDRTRAWEDFLQSTSGEHEQAEGGMPKNDGGTEGRNVEDLSSVTSSDGTIGQRVSNTRAWAEDPDDIQLDPMVTDVVYHDHGGECTGHGPSSSPERGWSYHMSGTHDGNVRAVPDTKVLPNAPKTTVPEEVREIDLIGLEDKFASAGLNPAAVPFVPKNQSTPTEEPPVIPEYYYGSGRRGDLSKSPPRGNVNLDSIKIYTSDDEDENQLEYEDEFAKSSSEVVIDTTPEDNDSINQEEVVGDPSDQGLEHPFPLGKFPEKEETPDVRRKDSLMQDSCKRGGVPKRLPMLSEEFECSGSDDPIIQELEREGSHPGGSLRLREPPQSSGNSRNQPDRQLKTGDAASPGGVQRPGTPMPKSRIMPIKKGTDAKSQYVGTEDVPGSKSGATRYVRGLPPNQESKSVTAENVQLSAPSAVTRNEGHDQEVTSNEDSLDDKYIMPSDDFANTFLPHDTDRLNYHADHLNDYDLETLCEESVLMGIVNAIKLINIDMRLNHIEEQMKEIPKIINKIDSIDRVLAKTNTALSTIEGHLVSMMIMIPGKGKGERKGKTNPELKPVIGRNILEQQELFSFDNLKNFRDGSLTDEPYGGVARIRDDLILPELNFSETNASQFVPLADDASKDVVRTMIRTHIKDRELRSELMDYLNRAETDEEVQEVANTVNDIIDGNI
Protein: Transcriptional coactivator YAP1
UniProt accession: P46937
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: YAP1, YAP65
Length: 504 residues
Disorder content (fraction disordered): 0.2420634920634921
Dataset labels: NDDs-related proteins, Condensates-related proteins
Curated region start positions: 101, 50
Curated region end positions: 171, 171
Curated region terms: disorder, disorder
Domain/feature annotations: 2.20.70.10, 2.20.70.10, WW domain, WW domain, Omega loop, TEAD interacting region 3
Cross-references: BMRB:27290, PDB:3KYS
Sequence:
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL
Protein: Growth arrest and DNA damage-inducible protein GADD45 alpha
UniProt accession: P24522
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DDIT1, GADD45, GADD45A
Length: 165 residues
Disorder content (fraction disordered): 0.18181818181818185
Curated region start positions: 1, 1, 105, 105, 105, 105
Curated region end positions: 16, 16, 118, 118, 118, 118
Curated region terms: disorder, disorder, disorder, molecular function regulator, protein binding, disorder
Domain/feature annotations: 3.30.1330.30, Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Cross-references: PDB:2KG4
Sequence:
MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER
Protein: Corneodesmosin
UniProt accession: Q15517
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CDSN
Length: 529 residues
Disorder content (fraction disordered): 0.21172022684310016
Dataset labels: Condensates-related proteins
Curated region start positions: 60, 60, 60
Curated region end positions: 171, 171, 171
Curated region terms: disorder, amyloid fibril formation, amyloid fibril formation
Sequence:
MGSSRAPWMGRVGGHGMMALLLAGLLLPGTLAKSIGTFSDPCKDPTRITSPNDPCLTGKGDSSGFSSYSGSSSSGSSISSARSSGGGSSGSSSGSSIAQGGSAGSFKPGTGYSQVSYSSGSGSSLQGASGSSQLGSSSSHSGNSGSHSGSSSSHSSSSSSFQFSSSSFQVGNGSALPTNDNSYRGILNPSQPGQSSSSSQTFGVSSSGQSVSSNQRPCSSDIPDSPCSGGPIVSHSGPYIPSSHSVSGGQRPVVVVVDQHGSGAPGVVQGPPCSNGGLPGKPCPPITSVDKSYGGYEVVGGSSDSYLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNPIIPSQSAASSAIAFQPVGTGGVQLCGGGSTGSKGPCSPSSSRVPSSSSISSSSGLPYHPCGSASQSPCSPPGTGSFSSSSSSQSSGKIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPSAGAKPCGSSSAGKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLNSP
Protein: Death domain-associated protein 6
UniProt accession: Q9UER7
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BING2, DAP6, DAXX
Length: 740 residues
Disorder content (fraction disordered): 0.6824324324324325
Dataset labels: Condensates-related proteins, Cancer-related proteins
Curated region start positions: 347, 495, 495, 495, 566, 161, 435, 1
Curated region end positions: 420, 740, 740, 740, 739, 243, 486, 50
Curated region terms: disorder, disorder, protein binding, molecular condensate scaffold activity, disorder, disorder, disorder, disorder
Domain/feature annotations: Daxx helical bundle domain, 1.20.58.2170, Daxx N-terminal Rassf1C-interacting domain, Death domain-associated protein 6, histone binding domain
Sequence:
MATANSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD
Protein: Death domain-associated protein 6
UniProt accession: O35613
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Daxx
Length: 739 residues
Disorder content (fraction disordered): 0.3152909336941813
Dataset labels: Condensates-related proteins
Curated region start positions: 566, 441
Curated region end positions: 739, 499
Curated region terms: disorder, disorder
Domain/feature annotations: Daxx helical bundle domain, 1.20.58.2170, Daxx N-terminal Rassf1C-interacting domain, Death domain-associated protein 6, histone binding domain
Sequence:
MATDDSIIVLDDDDEDEAAAQPGPSNLPPNPASTGPGPGLSQQATGLSEPRVDGGSSNSGSRKCYKLDNEKLFEEFLELCKTETSDHPEVVPFLHKLQQRAQSVFLASAEFCNILSRVLARSRKRPAKIYVYINELCTVLKAHSIKKKLNLAPAASTTSEASGPNPPTEPPSDLTNTENTASEASRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSSYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGLDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPTLARRLRENRTLAMNRLDEVISKYAMMQDKTEEGERQKRRARLLGTAPQPSDPPQASSESGEGPSGMASQECPTTSKAETDDDDDDDDDDDEDNEESEEEEEEEEEEKEATEDEDEDLEQLQEDQGGDEEEEGGDNEGNESPTSPSDFFHRRNSEPAEGLRTPEGQQKRGLTETPASPPGASLDPPSTDAESSGEQLLEPLLGDESPVSQLAELEMEALPEERDISSPRKKSEDSLPTILENGAAVVTSTSVNGRVSSHTWRDASPPSKRFRKEKKQLGSGLLGNSYIKEPMAQQDSGQNTSVQPMPSPPLASVASVADSSTRVDSPSHELVTSSLCSPSPSLLLQTPQAQSLRQCIYKTSVATQCDPEEIIVLSDSD
Protein: Protein chibby homolog 1
UniProt accession: Q9Y3M2
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ARB1, C22orf2, CBY, CBY1, HRIHFB2025, PGEA1
Length: 126 residues
Disorder content (fraction disordered): 0.7222222222222222
Dataset labels: NDDs-related proteins
Curated region start positions: 1, 1, 1, 1, 102, 102, 102, 1, 1
Curated region end positions: 63, 63, 63, 63, 126, 126, 126, 63, 66
Curated region terms: disorder, negative regulation of protein binding, disorder, negative regulation of protein binding, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: Chibby family
Sequence:
MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK
Protein: Lysine-specific demethylase 5B
UniProt accession: Q9UGL1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: JARID1B, KDM5B, PLU1, RBBP2H1
Length: 1544 residues
Disorder content (fraction disordered): 0.29080310880829013
Dataset labels: NDDs-related proteins
Curated region start positions: 115, 115, 188, 119, 1, 198, 339, 430, 441, 469, 543, 1078, 1271, 1376
Curated region end positions: 129, 129, 199, 128, 27, 311, 375, 453, 453, 481, 554, 1125, 1344, 1450
Curated region terms: disorder, nucleic acid binding, disorder, nucleic acid binding, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: ARID DNA-binding domain, Zinc/RING finger domain, C3HC4 (zinc finger), Zinc/RING finger domain, C3HC4 (zinc finger), Cupin, Cupin, PHD-finger, PHD-finger, PHD-finger, ARID/BRIGHT DNA binding domain, JmjC domain, hydroxylase, jmjN domain, C5HC2 zinc finger, PLU-1-like protein, Lysine-specific demethylase 5, C-terminal helical domain
Cross-references: DisProt:DP00712r010, PDB:5FPU
Sequence:
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEFDVELPQLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAGGRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTENSPYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWDNRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQQTDRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVKDAPSRK
Protein: Prelamin-A/C
UniProt accession: P02545
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: LMN1, LMNA
Length: 664 residues
Disorder content (fraction disordered): 0.14759036144578314
Dataset labels: Cancer-related proteins, Condensates-related proteins, Age-related disorders proteins
Curated region start positions: 567
Curated region end positions: 664
Curated region terms: disorder
Domain/feature annotations: Vasodilator-stimulated phosphoprotein, Lamin Tail domain, 1.20.5.170, Single helix bin, Intermediate filament protein, Lamin Tail Domain
Sequence:
METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM
Protein: Methylosome subunit pICln
UniProt accession: P35521
Organism: Canis lupus familiaris
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Laurasiatheria, Carnivora, Caniformia, Canidae, Canis
Gene names: CLNS1A, ICLN
Length: 235 residues
Disorder content (fraction disordered): 0.14468085106382975
Curated region start positions: 75, 75, 75, 75, 93, 93, 93, 93
Curated region end positions: 85, 85, 85, 85, 115, 115, 115, 115
Curated region terms: disorder, protein binding, small molecule binding, lipid binding, disorder, protein binding, small molecule binding, lipid binding
Domain/feature annotations: Regulator of volume decrease after cellular swelling
Cross-references: PDB:1ZYI
Sequence:
MSFLKSFPPPGSAEGLRQQQPETEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDLNAYPREHLYVMVNAKFGEESKESVAEEEDSDDDVEPIAEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSTRDYEDGMEVDTTPTVAGQFEDADVDH
Protein: Peroxisome proliferator-activated receptor gamma
UniProt accession: P37231
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NR1C3, PPARG
Length: 505 residues
Disorder content (fraction disordered): 0.592079207920792
Dataset labels: Cancer-related proteins
Curated region start positions: 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 9, 112, 112, 112, 112, 112, 112, 112, 112, 175, 175, 175, 175, 175, 175, 238, 238, 238, 238, 238, 238, 279, 279, 279, 279, 279, 279, 443, 443, 443, 443, 443, 443, 443, 443, 453, 453, 453, 453, 453, 453
Curated region end positions: 111, 111, 111, 111, 111, 111, 111, 111, 111, 111, 111, 111, 174, 174, 174, 174, 174, 174, 174, 174, 211, 211, 211, 211, 211, 211, 278, 278, 278, 278, 278, 278, 298, 298, 298, 298, 298, 298, 452, 452, 452, 452, 452, 452, 452, 452, 477, 477, 477, 477, 477, 477
Curated region terms: disorder, molecular function regulator, protein binding, disorder, molecular function regulator, protein binding, disorder, molecular function regulator, protein binding, disorder, molecular function regulator, protein binding, disorder, molecular function regulator, disorder to order, protein binding, disorder, molecular function regulator, disorder to order, protein binding, disorder, molecular function regulator, nucleic acid binding, disorder, molecular function regulator, nucleic acid binding, disorder, molecular function regulator, protein binding, disorder, molecular function regulator, protein binding, disorder, molecular function regulator, disorder to order, disorder, molecular function regulator, disorder to order, disorder, molecular function regulator, order to disorder, protein binding, disorder, molecular function regulator, order to disorder, protein binding, disorder, molecular function regulator, protein binding, disorder, molecular function regulator, protein binding
Domain/feature annotations: Erythroid Transcription Factor GATA-1, subunit A, Retinoid X Receptor, Ligand-binding domain of nuclear hormone receptor, Double treble clef zinc finger, C4 type, PPAR gamma N-terminal region
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Protein: G/T mismatch-specific thymine DNA glycosylase
UniProt accession: Q13569
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TDG
Length: 410 residues
Disorder content (fraction disordered): 0.44390243902439025
Curated region start positions: 1, 1, 51, 51, 51, 51, 340, 340
Curated region end positions: 50, 50, 111, 111, 111, 111, 410, 410
Curated region terms: disorder, molecular function regulator, disorder, molecular function regulator, disorder to order, nucleic acid binding, disorder, self-inhibition
Domain/feature annotations: Uracil DNA glycosylase superfamily
Sequence:
MEAENAGSYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKGRKRKPRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNMDVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCSSEPCGFSSNGLIESVELRGESAFSGIPNGQWMTQSFTDQIPSFSNHCGTQEQEEESHA
Protein: FACT complex subunit Ssrp1
UniProt accession: Q05344
Organism: Drosophila melanogaster
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Arthropoda, Hexapoda, Insecta, Pterygota, Neoptera, Endopterygota, Diptera, Brachycera, Muscomorpha, Ephydroidea, Drosophilidae, Drosophila, Sophophora
Gene names: CF5, CG4817, SSRP1, Ssrp
Length: 723 residues
Disorder content (fraction disordered): 0.30013831258644535
Curated region start positions: 437, 519, 519, 519, 519, 437, 625
Curated region end positions: 518, 554, 554, 554, 554, 518, 723
Curated region terms: disorder, disorder, protein binding, disorder, protein binding, disorder, disorder
Domain/feature annotations: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), High mobility group box domain, Structure-specific recognition protein (SSRP1), 2.30.29.150, HMG (high mobility group) box, Structure-specific recognition protein (SSRP1), Histone chaperone Rttp106-like, middle domain, POB3-like N-terminal PH domain, SSRP1 PH domain
Sequence:
MTDSLEYNDINAEVRGVLCSGRLKMTEQNIIFKNTKTGKVEQISAEDIDLINSQKFVGTWGLRVFTKGGVLHRFTGFRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDKESKTIFEVPLSHVSQCVTGKNEVTLEFHQNDDAPVGLLEMRFHIPAVESAEEDPVDKFHQNVMSKASVISASGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDYKIPMDSVLRLFMLPHKDSRQMFFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDKYEGKLEKEISGPVYEVMGKVMKVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYIHKPPLHIRFEEISSVNFARSGGSTRSFDFEVTLKNGTVHIFSSIEKEEYAKLFDYITQKKLHVSNMGKDKSGYKDVDFGDSDNENEPDAYLARLKAEAREKEEDDDDGDSDEESTDEDFKPNENESDVAEEYDSNVESDSDDDSDASGGGGDSDGAKKKKEKKSEKKEKKEKKHKEKERTKKPSKKKKDSGKPKRATTAFMLWLNDTRESIKRENPGIKVTEIAKKGGEMWKELKDKSKWEDAAAKDKQRYHDEMRNYKPEAGGDSDNEKGGKSSKKRKTEPSPSKKANTSGSGFKSKEYISDDDSTSSDDEKDNEPAKKKSKPPSDGDAKKKKAKSESEPEESEEDSNASDEDEEDEASD
Protein: FACT complex subunit spt16
UniProt accession: Q8IRG6
Organism: Drosophila melanogaster
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Arthropoda, Hexapoda, Insecta, Pterygota, Neoptera, Endopterygota, Diptera, Brachycera, Muscomorpha, Ephydroidea, Drosophilidae, Drosophila, Sophophora
Gene names: CG1828, dre4, spt16
Length: 1083 residues
Disorder content (fraction disordered): 0.1440443213296399
Curated region start positions: 889
Curated region end positions: 1044
Curated region terms: disorder
Domain/feature annotations: Creatinase/prolidase N-terminal domain, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Creatinase/methionine aminopeptidase superfamily, FACT complex subunit Spt16p/Cdc68p, 2.30.29.150, Metallopeptidase family M24, Histone chaperone Rttp106-like, middle domain, FACT complex subunit (SPT16/CDC68), FACT complex subunit SPT16 N-terminal lobe domain, FACT complex subunit SPT16, C-terminal domain, FACT complex subunit SPT16 PH-like domain
Sequence:
MSSFVLDKEAFVRRVKRLYTEWRAPSIGHDDALRNLDCIMSIVGVEEDVMYSKSMALQLWLLGYELTDTISVFCSDAVYFLTSKKKIEFLKQTQNITEEGFPEINLLVRDRTDKDQGNFEKLIKALQNSKKGKRLGVFAKDAYPGEFSEAWKKSLTASKFEHVDISTIIAYLMCPKDESEINNIRKASLVSMDIFNKYLKDEIMDIIDSDRKVKHNKLSDGCEAAIGEKKYTSGLDPRLLDMAYPPIIQSGGAYSLKFSAVADKNPLHFGVIVCSLGARYKSYCSNISRTFLVNPTEAMQENYTFLVSVQEEILKLLVPGTKLCDVYEKTLDFVKKEKPSMVDNLPKSFGFAMGLEFRENSIVIGPKCQALLKKNMVFNLHVGISNLTNPEATDKEGKNYALFIGDTVLVGEQSPASVMTPSKKKIKNVGIFIKDDSDEEDVDDKKTAKEDQGTEILGRSKRNAVLESKLRNEINTEEKRKEHQRELAQQLNERAKDRLARQGNSKEVEKVRKNTVSYKSISQMPREPEVKELKLYVDKKYETVIMPVFGIQVPFHISTIKNISQSVEGEYTYLRINFFHPGATMGRNEGGLYPQPEATFVKEVTYRSSNVKEHGEVGAPSANLNNAFRLIKEVQKRFKTREAEEREKEDLVKQDTLILSQNKGNPKLKDLYIRPNIVTKRMTGSLEAHSNGFRYISVRGDKVDILYNNIKSAFFQPCDGEMIILLHFHLKYAIMFGKKKHVDVQFYTEVGEITTDLGKHQHMHDRDDLAAEQAERELRHKLKTAFKSFCEKVETMTKSVVEFDTPFRELGFPGAPFRSTVTLQPTSGSLVNLTEWPPFVITLDDVELVHFERVQFHLRNFDMIFVFKEYNKKVAMVNAIPMNMLDHVKEWLNSCDIRYSEGVQSLNWQKIMKTITDDPEGFFEQGGWTFLDPESGSEGENETAESEEDEAYNPTDAESDEESDEDSEYSEASEDSEESDEDLGSDEESGKDWSDLEREAAEEDRNHDYAADDKPRNGKFDSKKHGKSSKHSPSKSSKDKYNSRDKHHSSSSSGNKSSSKDKDRKRSRDDSRDNGHKSKKSRH