LiteFold/DisProt huggingface dataset:
Protein: Ubiquitin-conjugating enzyme E2 T
UniProt accession: Q9NPD8
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HSPC150, PIG50, UBE2T
Length: 197 residues
Disorder content (fraction disordered): 0.20812182741116753
Curated region start positions: 157, 157
Curated region end positions: 197, 197
Curated region terms: disorder, flexible C-terminal tail
Domain/feature annotations: Ubiquitin-conjugating enzyme
Sequence:
MQRASRLKRELHMLATEPPPGITCWQDKDQMDDLRAQILGGANTPYEKGVFKLEVIIPERYPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATVLTSIQLLMSEPNPDDPLMADISSEFKYNKPAFLKNARQWTEKHARQKQKADEEEMLDNLPEAGDSRVHNSTQKRKASQLVGIEKKFHPDV
Protein: Auxin-responsive protein IAA17
UniProt accession: P93830
Organism: Arabidopsis thaliana
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, rosids, malvids, Brassicales, Brassicaceae, Camelineae, Arabidopsis
Gene names: AXR3, At1g04250, F19P19.31, IAA17
Length: 229 residues
Disorder content (fraction disordered): 0.5414847161572053
Curated region start positions: 1, 1, 150, 150
Curated region end positions: 101, 101, 172, 172
Curated region terms: disorder, disorder, disorder, flexible linker
Domain/feature annotations: AUX/IAA family
Cross-references: BMRB:25217, BMRB:52109, PDB:2MUK
Sequence:
MMGSVELNLRETELCLGLPGGDTVAPVTGNKRGFSETVDLKLNLNNEPANKEGSTTHDVVTFDSKEKSACPKDPAKPPAKAQVVGWPPVRSYRKNVMVSCQKSSGGPEAAAFVKVSMDGAPYLRKIDLRMYKSYDELSNALSNMFSSFTMGKHGGEEGMIDFMNERKLMDLVNSWDYVPSYEDKDGDWMLVGDVPWPMFVDTCKRLRLMKGSDAIGLAPRAMEKCKSRA
Protein: COP9 signalosome complex subunit 9
UniProt accession: Q8WXC6
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: COPS9, MYEOV2
Length: 57 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1
Curated region end positions: 40, 57
Curated region terms: disorder, disorder
Domain/feature annotations: Myeloma-overexpressed-like
Cross-references: BMRB:50908
Sequence:
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDIQ
Protein: Apolipoprotein A-I
UniProt accession: P02647
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: APOA1
Length: 267 residues
Disorder content (fraction disordered): 0.9101123595505618
Dataset labels: Age-related disorders proteins
Curated region start positions: 210, 140, 25, 70, 70, 25, 44
Curated region end positions: 267, 170, 267, 83, 83, 267, 54
Curated region terms: disorder, disorder, amyloid-beta formation, disorder to order, amyloid-beta formation, molten globule, disorder
Domain/feature annotations: Apolipoprotein A1/A4/E domain
Sequence:
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
Protein: DNA polymerase alpha catalytic subunit
UniProt accession: P33609
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Pola, Pola1
Length: 1465 residues
Disorder content (fraction disordered): 0.22525597269624573
Curated region start positions: 1, 1, 220, 1
Curated region end positions: 330, 330, 330, 330
Curated region terms: disorder, disorder, protein binding, protein binding
Domain/feature annotations: DNA polymerase family B, DNA polymerase family B, exonuclease domain, DNA Polymerase alpha zinc finger, DNA polymerase alpha subunit p180 N terminal
Sequence:
MAPMHEEDCKLEASAVSDSGSFAASRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDLTSVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDTCGKGSDGKAHRKDRKDVKKPSVTKPNNIKAMFIASAGKKTTDKAVDLSKDDLLGDILQDLNTETAQITPPPVLIPKKKRSTGALLNPFSVHTPKAIPSGKPASPVLRNEPLLTPIPLKRAELAGELAQPECPEDEQELGVMEFEDGDFDESMDTEKVDEKPVTAKTWDQETEPVERVEHEADPERGTTSYLENFLPDVSCWDIDQDDESIPQEVQVDSSNLPLVKGADDEQVFQFYWLDAYEDPYNQPGVVFLFGKVWIESVKTHVSCCVMVKNIERTLYFLPREMKFDLNTGKETAIPVTMKDVYEEFDSKISAKYKIMKFKSKIVEKNYAFEIPDVPEKSEYLEVRYSAEVPQLPQNLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKNPQLLNQPISWCKFEVMALKPDLVNVIKDVSPPPLVVMSFSMKTMQNVQNHQHEIIAMAALVHHSFALDKAPPEPPFQTHFCVVSKPKDCIFPCDFKEVISKKNMKVEIAATERTLIGFFLAKVHKIDPDILVGHNICSFELEVLLQRINECKVPYWSKIGRLRRSNMPKLGSRSGFGERNATCGRMICDVEISAKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYSESSYLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKATYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVTSEVQKATEDEEQEQIPELPDPNLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKDMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDAVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDRKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTATQRAYAPEQLQKLDNLAIDTQYYLAQQIHPVVARICEPIDGIDAVLIALWLGLDSTQFRVHQYHKDEENDALLGGPAQLTDEEKYKDCEKFKCLCPSCGTENIYDNVFEGSGLDMEPSLYRCSNVDCKVSPLTFMVQLSNKLIMDIRRCIKKYYDGWLICEEPTCCSRLRRLPLHFSRNGPLCPVCMKAVLRPEYSDKSLYTQLCFYRYIFDADCALEKLTEHEKDKLKKQFFPLRVLQDYRKVKNIAEQFLSWSGYSEVNLSKLFANYAGKS
Protein: Caspase recruitment domain-containing protein 8
UniProt accession: Q9Y2G2
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CARD8, DACAR, KIAA0955, NDPP1
Length: 537 residues
Disorder content (fraction disordered): 0.3016759776536313
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 162, 162, 162, 162
Curated region terms: disorder, flexible N-terminal tail, positive regulation of inflammatory response, protein destabilization
Domain/feature annotations: Caspase recruitment domain, Function to find, UPA-FIIND domain
Sequence:
MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFFQAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSEEQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL
Protein: Exosome complex exonuclease RRP46 homolog
UniProt accession: Q84T68
Organism: Oryza sativa subsp. japonica
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, Liliopsida, Poales, Poaceae, BOP clade, Oryzoideae, Oryzeae, Oryzinae, Oryza, Oryza sativa
Gene names: LOC_Os03g63720, Os03g0854200, RRP46
Length: 238 residues
Disorder content (fraction disordered): 0.06302521008403361
Dataset labels: RNA-binding proteins
Curated region start positions: 177
Curated region end positions: 191
Curated region terms: disorder
Domain/feature annotations: 3' exoribonuclease family, domain 1
Cross-references: PDB:3HKM
Sequence:
MEESRADGRNPNQLRPFSCTRNPLDRAHGSARWAQGDTIVLAAVYGPKPGTRKGENPEKASIEVVWKPMTGQIGKQEKEYEMTLKRTLQSICLLTVHPNTTTSVILQVVGNDGSLLPCAINACCAALVFAGIPLKHLAVAIGCGVLEDGEVILDTNKAEEQQLKSFAHLVFPNSRKSASSKEPNQKEEDSERGLITSITHGVMSEEDYFSCIERGLAASSRISDFMRTTLQKQAPGDV
Protein: Phosphatidylinositol-3-phosphate phosphatase MTMR1
UniProt accession: Q13613
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MTMR1
Length: 665 residues
Disorder content (fraction disordered): 0.14135338345864662
Dataset labels: Age-related disorders proteins
Curated region start positions: 1, 1, 1
Curated region end positions: 94, 94, 94
Curated region terms: disorder, flexible N-terminal tail, protein destabilization
Domain/feature annotations: GRAM domain, Myotubularin-like phosphatase domain
Sequence:
MDRPAAAAAAGCEGGGGPNPGPAGGRRPPRAAGGATAGSRQPSVETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGESIKAIVKDVMYICPFMGAVSGTLTVTDFKLYFKNVERDPHFILDVPLGVISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKFPINGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNYENHVLYPVASLSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAVRAELQKRVEGLQREVATRAVSSSSERGSSPSHSATSVHTSV
Protein: D-2-hydroxyglutarate dehydrogenase, mitochondrial
UniProt accession: Q8N465
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: D2HGD, D2HGDH
Length: 521 residues
Disorder content (fraction disordered): 0.09788867562380038
Dataset labels: NDDs-related proteins
Curated region start positions: 1, 1, 1
Curated region end positions: 51, 51, 51
Curated region terms: disorder, flexible N-terminal tail, protein destabilization
Domain/feature annotations: FAD binding domain, FAD linked oxidases, C-terminal domain
Sequence:
MLPRRPLAWPAWLLRGAPGAAGSWGRPVGPLARRGCCSAPGTPEVPLTRERYPVRRLPFSTVSKQDLAAFERIVPGGVVTDPEALQAPNVDWLRTLRGCSKVLLRPRTSEEVSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQAGCVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLGLEVVLADGTVLDCLTSLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVAFLGCPGFAEVLQTFSTCKGMLGEILSAFEFMDAVCMQLVGRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA
Protein: U3 small nucleolar RNA-associated protein NOL7
UniProt accession: Q9UMY1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: C6orf90, NOL7, NOP27
Length: 257 residues
Disorder content (fraction disordered): 0.3657587548638132
Curated region start positions: 1, 1
Curated region end positions: 94, 94
Curated region terms: disorder, flexible N-terminal tail
Domain/feature annotations: NUC129 domain
Sequence:
MVQLRPRASRAPASAEAMVDEGQLASEEEEAEHGLLLGQPSSGAAAEPLEEDEEGDDEFDDEAPEELTFASAQAEAREEERRVRETVRRDKTLLKEKRKRREELFIEQKKRKLLPDTILEKLTTASQTNIKKSPGKVKEVNLQKKNEDCEKGNDSKKVKVQKVQSVSQNKSYLAVRLKDQDLRDSRQQAAQAFIHNSLYGPGTNRTTVNKFLSLANKRLPVKRAAVQFLNNAWGIQKKQNAKRFKRRWMVRKMKTKK
Protein: Frequency clock protein
UniProt accession: P19970
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Pezizomycotina, Sordariomycetes, Sordariomycetidae, Sordariales, Sordariaceae, Neurospora
Gene names: B13D24.170, NCU02265, frq
Length: 989 residues
Disorder content (fraction disordered): 1
Dataset labels: Condensates-related proteins
Curated region start positions: 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
Curated region end positions: 989, 989, 989, 989, 989, 989, 989, 989, 989, 989, 989
Curated region terms: disorder, disorder, protein homodimerization activity, phosphorylation display site, disorder, protein binding, protein binding, molecular condensate scaffold activity, molecular condensate scaffold activity, nucleus, non-membrane-bounded organelle assembly
Domain/feature annotations: Frequency clock protein
Sequence:
MADSGDKSQGMRPPPFDSRGHPLPRRASPDKSITLENHRLARDTSSRVTSSSALGVTESQPQLKSSPTRRNSSGESEPTNWFNQSNRNPAAAFHDESHIMEVDPPFYQKETDSSNEESRYPPGRNPVHPPGGVQLPGFRPVAAHSSAADDYRSVIDDLTVENKRLKEELKRYKQFGSDVMRKEKLFEIKVHGLPRRKKRELEATLRDFAASLGDSSESTSQRRKTGRHGTAVHSSGVSLSKHDSSSSSRSRPVDSAYNSMSTGRSSHAPHSSGPSLGRPSLTRAKSVGTQKVENYLRDTPDGLLPHHIVMTDKEKKKLVVRRLEQLFTGKISGRNMQRNQSMPSMDAPLAPEGTNMAPPRPPPEGLREACIQLQDGDNPRKNRSSKDNGSASNSGGDQTELGGTGTGSGDGSGSGGRTGNNTSPPGAIAPDQRPTRPRDLDPDRVQIPSENMDYIRHLGLVSPEFLQGSRTSYQDVAPDAEGWVYLNLLCNLAQLHMVNVTPSFIRQAVSEKSTKFQLSADGRKIRWRGGTDGTKFSSDSSEDKSQQSPMTEDTEDGSDKNGRRKKRKTQQASSEIGRFGPSRSPSDTFHYKPMFVHRNSSSIETSLEESMSQGSEDAVDESNMGNSKWDFSGSGTTQQRRKRRYDGAIVYYTGAPFCTDLSGDPGDMSPTAQMTAGREVEGSGSGDEVEHVLQRTLSGSSLPIRPLSDDRARVAEVLDFDPGNPPELVADDGSSPNDEDFVFPWCEDPAKVRIQPIAKEVMEPSGLGGVLPDDHFVMLVTTRRVVRPILQRQLSRSTTSEDTAEFIAERLAAIRTSSPLPPRSHRLTVAPLQVEYVSGQFRRLNPAPLPPPAIFYPPFSTDSSWDDGDDLASDDEEVEEVEEDSYSEGQISRRANPHFSDNNTYMRKDDLAFDTETDVRMDSDDNRLSDSGHNMRAMMPRAEAVDGDDSPLAAVTGKEVDMLHTGSSVATAGGAESGYSSSMEDVSSS
Protein: Histone H3.1
UniProt accession: P68431
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Length: 136 residues
Disorder content (fraction disordered): 0.27941176470588236
Dataset labels: Cancer-related proteins, Condensates-related proteins
Curated region start positions: 1, 1
Curated region end positions: 38, 38
Curated region terms: disorder, flexible N-terminal tail
Domain/feature annotations: Core histone H2A/H2B/H3/H4 domain
Sequence:
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein: Transcriptional regulatory protein BaeR
UniProt accession: P69229
Organism: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomy: Bacteria, Pseudomonadota, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: baeR, c2605
Length: 240 residues
Disorder content (fraction disordered): 0.0625
Curated region start positions: 127
Curated region end positions: 141
Curated region terms: disorder
Domain/feature annotations: Response regulator receiver domain, Transcriptional regulatory protein, C terminal
Cross-references: PDB:4B09
Sequence:
MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV
Protein: Serine/threonine-protein kinase Nek7
UniProt accession: Q8TDX7
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NEK7
Length: 302 residues
Disorder content (fraction disordered): 0.10927152317880796
Curated region start positions: 182, 190, 182, 1, 1, 190
Curated region end positions: 195, 195, 195, 19, 19, 195
Curated region terms: disorder, phosphorylation display site, flexible linker, flexible N-terminal tail, disorder, regulation of kinase activity
Domain/feature annotations: Protein kinase domain
Cross-references: PDB:2WQM, PDB:5DE2
Sequence:
MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS
Protein: Lariat debranching enzyme
UniProt accession: Q9UK59
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DBR1
Length: 544 residues
Disorder content (fraction disordered): 0.2775735294117647
Curated region start positions: 394, 503, 394
Curated region end positions: 544, 544, 544
Curated region terms: disorder, protein stabilization, flexible C-terminal tail
Domain/feature annotations: Calcineurin-like phosphoesterase, Lariat debranching enzyme, C-terminal domain
Sequence:
MRVAVAGCCHGELDKIYETLALAERRGPGPVDLLLCCGDFQAVRNEADLRCMAVPPKYRHMQTFYRYYSGEKKAPVLTLFIGGNHEASNHLQELPYGGWVAPNIYYLGLAGVVKYRGVRIGGISGIFKSHDYRKGHFECPPYNSSTIRSIYHVRNIEVYKLKQLKQPIDIFLSHDWPRSIYHYGNKKQLLKTKSFFRQEVENNTLGSPAASELLEHLKPTYWFSAHLHVKFAALMQHQAKDKGQTARATKFLALDKCLPHRDFLQILEIEHDPSAPDYLEYDIEWLTILRATDDLINVTGRLWNMPENNGLHARWDYSATEEGMKEVLEKLNHDLKVPCNFSVTAACYDPSKPQTQMQLIHRINPQTTEFCAQLGIIDINVRLQKSKEEHHVCGEYEEQDDVESNDSGEDQSEYNTDTSALSSINPDEIMLDEEEDEDSIVSAHSGMNTPSVEPSDQASEFSASFSDVRILPGSMIVSSDDTVDSTIDREGKPGGTVESGNGEDLTKVPLKRLSDEHEPEQRKKIKRRNQAIYAAVDDDDDDAA
Protein: M-phase-specific PLK1-interacting protein
UniProt accession: Q8TAP9
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: C7orf11, MPLKIP, TTDN1
Length: 179 residues
Disorder content (fraction disordered): 0.8659217877094972
Dataset labels: NDDs-related proteins
Curated region start positions: 1, 160
Curated region end positions: 135, 179
Curated region terms: disorder, disorder
Domain/feature annotations: M-phase-specific PLK1-interacting protein
Sequence:
MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDGYGSPHHTPPYGPRSRPYGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFGYSPGQQQTHPQGSPRTSTPFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFC
Protein: Tax1-binding protein 3
UniProt accession: O14907
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TAX1BP3, TIP1
Length: 124 residues
Disorder content (fraction disordered): 0.1774193548387097
Curated region start positions: 1, 113
Curated region end positions: 10, 124
Curated region terms: disorder, disorder
Domain/feature annotations: PDZ domain
Cross-references: BMRB:17254, PDB:2L4S
Sequence:
MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS
Protein: Beta-arrestin-1
UniProt accession: P29066
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Arrb1
Length: 418 residues
Disorder content (fraction disordered): 0.05502392344497608
Curated region start positions: 360
Curated region end positions: 382
Curated region terms: disorder
Domain/feature annotations: Arrestin (or S-antigen), N-terminal domain, Arrestin (or S-antigen), C-terminal domain
Cross-references: PDB:8HSV
Sequence:
MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPPHREVPESETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKDEEDDGTGSPHLNNR
Protein: Histone H3-like centromeric protein cid
UniProt accession: Q9V6Q2
Organism: Drosophila melanogaster
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Arthropoda, Hexapoda, Insecta, Pterygota, Neoptera, Endopterygota, Diptera, Brachycera, Muscomorpha, Ephydroidea, Drosophilidae, Drosophila, Sophophora
Gene names: CENP-A, CG13329, cid
Length: 225 residues
Disorder content (fraction disordered): 0.6488888888888888
Curated region start positions: 101, 1
Curated region end positions: 146, 131
Curated region terms: disorder, disorder
Domain/feature annotations: Core histone H2A/H2B/H3/H4 domain
Cross-references: PDB:6XWT
Sequence:
MPRHSRAKRAPRPSANNSKSPNDDDTAFRSPEPEDGTDYGLEFTTSQLTLQDNNRRSSTLRRDAGRRQPAARDSSTSGEEEDQENRYPTTRSPQTRRMTVQQESKTRAAGPVAAQNQTRRRKAANPMSRAKRMDREIRRLQHHPGTLIPKLPFSRLVREFIVKYSDDEPLRVTEGALLAMQESCEMYLTQRLADSYMLTKHRNRVTLEVRDMALMAYICDRGRQF
Protein: MBD domain-containing protein
UniProt accession: I1KDC1
Organism: Glycine max
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, rosids, fabids, Fabales, Fabaceae, Papilionoideae, 50 kb inversion clade, NPAAA clade, indigoferoid/millettioid clade, Phaseoleae, Glycine, Glycine subgen. Soja
Gene names: 100796239, GLYMA_06G217500
Length: 305 residues
Disorder content (fraction disordered): 0.740983606557377
Curated region start positions: 80, 80
Curated region end positions: 305, 305
Curated region terms: disorder, disorder
Domain/feature annotations: Methyl-CpG binding domain
Sequence:
MASAVEKEGGASEETLSLELPAPPGWKKQFIPKKAGTPKKNEIVFTAPTGEEINNRKQLEKYLKAHPGGPAVSEFDWGTGETPRRSTRISEKAKAAPPTQREPPKKRTKRSSASQKEISQEEKEEETKEAEMQEADDTTKGDNDIEKEKVVVNENHDKSVEDTDVNKSTRYGEEAKAGENVEVPIEEEKSNAADGELPALKDKADDKVTEGSEVFLRKDEEKIEQPQEETKEYSGFGEPEKLETCTTADKTVEVEGVNKEDHVKSTHEFEVGEIEGTKVNGEEHHKLDEINKAEAELTVNGTHES
Protein: Receptor-interacting serine/threonine-protein kinase 3
UniProt accession: Q9Y572
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: RIP3, RIPK3
Length: 518 residues
Disorder content (fraction disordered): 0.4227799227799228
Dataset labels: Condensates-related proteins
Curated region start positions: 387, 387, 430, 388, 470, 476, 418, 447, 447, 448, 448, 388, 388, 448, 446, 388, 388, 457, 457, 300
Curated region end positions: 518, 518, 465, 447, 518, 518, 446, 475, 475, 469, 469, 518, 518, 462, 464, 518, 518, 461, 461, 518
Curated region terms: disorder, amyloid fibril formation, identical protein binding, disorder, disorder, disorder, disorder, order, disorder to order, disorder to order, order, amyloid fibril formation, ripoptosome, protein serine/threonine kinase binding, protein serine/threonine kinase binding, amyloid fibril formation, ripoptosome assembly involved in necroptotic process, necroptotic process, activation of protein kinase activity, disorder
Domain/feature annotations: Protein kinase domain, RIP homotypic interaction motif
Cross-references: EMDB:30622, PDB:5V7Z, PDB:7DA4, PDB:7DAC
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
Protein: mRNA-decapping enzyme subunit 1
UniProt accession: Q12517
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: DCP1, YOL149W
Length: 231 residues
Disorder content (fraction disordered): 0.30303030303030304
Dataset labels: Condensates-related proteins, RNA-binding proteins
Curated region start positions: 1, 81
Curated region end positions: 16, 134
Curated region terms: disorder, disorder
Domain/feature annotations: Dcp1-like decapping family, Dcp1-like decapping family
Cross-references: PDB:1Q67
Sequence:
MTGAATAAENSATQLEFYRKALNFNVIGRYDPKIKQLLFHTPHASLYKWDFKKDEWNKLEYQGVLAIYLRDVSQNTNLLPVSPQEVDIFDSQNGSNNIQVNNGSDNSNRNSSGNGNSYKSNDSLTYNCGKTLSGKDIYNYGLIILNRINPDNFSMGIVPNSVVNKRKVFNAEEDTLNPLECMGVEVKDELVIIKNLKHEVYGIWIHTVSDRQNIYELIKYLLENEPKDSFA