LiteFold/DisProt huggingface dataset:
Protein: Na(+)/H(+) exchange regulatory cofactor NHE-RF1
UniProt accession: O14745
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NHERF, NHERF1, SLC9A3R1
Length: 358 residues
Disorder content (fraction disordered): 0.3268156424581006
Curated region start positions: 242, 242, 242, 242, 242, 242, 242, 242, 242
Curated region end positions: 358, 358, 358, 358, 358, 358, 358, 358, 358
Curated region terms: disorder, protein binding, disorder, disorder to order, disorder, disorder to order, protein binding, disorder, protein binding
Domain/feature annotations: 2.30.42.10, 2.30.42.10, PDZ domain, EBP50, C-terminal, PDZ domain
Cross-references: PDB:2JXO, PDB:2KRG
Sequence:
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
Protein: DNA-(apurinic or apyrimidinic site) lyase
UniProt accession: O15922
Organism: Leishmania major
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: LMJF_16_0680, LmAP
Length: 447 residues
Disorder content (fraction disordered): 0.24608501118568232
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1, 230, 315
Curated region end positions: 89, 240, 324
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Endonuclease/exonuclease/phosphatase, Endonuclease/Exonuclease/phosphatase family
Cross-references: PDB:2J63
Sequence:
MASKRCRQCSGDSASSSTSSLSPSELPPSKKAAGGQRVTAEVEVAPITTDATSATVTAAGGAKKKATTGSPARRTSSAAKITNGDAGELIRTAEALAALNAKKSEKEIWSDVVPFVRRTTDSDFDPSRMYKFITWNVAGLRGLLKKNASALRAFMEAEKPDVLCLQETKLNVDEADANATLGVVDGYSFVDHPCAFKRGYSGTRTYMKNSTTVKGLHARCTRGFALPSEPQADAAAGSRVLVEGAGDEEGRVLTTFLSPDPDSASSSSRIALVNTYVANSGMGLTRLPYRVQSFDPSMREYLHRLDTWATENAAVPSAAAMGSGSSPHGFIWAGDLNVAERDYDRYYAGTFKSMQECSGFAPEERMSFRETMQRTNSVDIFRQLYPQAGPVYSFWSQRINGRPRNLGWRLDYFVVSSRLASYVVDCFPMPTVMGSDHCPFQMWMRHP
Protein: Cyclic AMP-responsive element-binding protein 1
UniProt accession: P16220
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CREB1
Length: 327 residues
Disorder content (fraction disordered): 0.1834862385321101
Dataset labels: Cancer-related proteins
Curated region start positions: 101, 101
Curated region end positions: 160, 160
Curated region terms: disorder, disorder to order
Domain/feature annotations: 1.20.5.170, bZIP transcription factor, pKID domain
Sequence:
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Protein: Alpha-S1-casein
UniProt accession: P47710
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CASA, CSN1, CSN1S1
Length: 185 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1
Curated region end positions: 185
Curated region terms: disorder
Sequence:
MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW
Protein: Thymidine kinase, cytosolic
UniProt accession: P04183
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TK1
Length: 234 residues
Disorder content (fraction disordered): 0.2948717948717949
Curated region start positions: 64, 1, 193
Curated region end positions: 73, 17, 234
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: P-loop containing nucleotide triphosphate hydrolases, 3.30.60.20, Thymidine kinase
Cross-references: PDB:2WVJ
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
Protein: Zinc finger protein 106
UniProt accession: Q9H2Y7
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SH3BP3, ZFP106, ZNF106, ZNF474
Length: 1883 residues
Disorder content (fraction disordered): 0.13648433351035583
Curated region start positions: 1265, 1265, 1256, 1300
Curated region end positions: 1521, 1521, 1521, 1400
Curated region terms: disorder, protein binding, protein binding, protein binding
Domain/feature annotations: YVTN repeat-like/Quinoprotein amine dehydrogenase, YVTN repeat-like/Quinoprotein amine dehydrogenase, Classic Zinc Finger, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat
Sequence:
MPVGRIECPSSPSFPRDISHECRVCGVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKGEEEEEDYFDKELIQLIKQRKEQSRQDEPSNSNQEINSDDRRPQWRREDRIPYQDRESYSQPAWHHRGPPQRDWKWEKDGFNNTRKNSFPHSLRNGGGPRGRSGWHKGVAGGSSTWFHNHSNSGGGWLSNSGAVDWNHNGTGRNSSWLSEGTGGFSSWHMNNSNGNWKSSVRSTNNWNYSGPGDKFQPGRNRNSNCQMEDMTMLWNKKSNKSNKYSHDRYNWQRQENDKLGTVATYRGPSEGFTSDKFPSEGLLDFNFEQLESQTTKQADTATSKVSGKNGSAAREKPRRWTPYPSQKTLDLQSGLKDITGNKSEMIEKPLFDFSLITTGIQEPQTDETRNSPTQKTQKEIHTGSLNHKASSDSAASFEVVRQCPTAEKPEQEHTPNKMPSLKSPLLPCPATKSLSQKQDPKNISKNTKTNFFSPGEHSNPSNKPTVEDNHGPYISKLRSSCPHVLKGNKSTFGSQKQSGDNLNDTLRKAKEVLQCHESLQNPLLSTSKSTRNYAKASRNVEESEKGSLKIEFQVHALEDESDGETSDTEKHGTKIGTLGSATTELLSGSTRTADEKEEDDRILKTSRELSTSPCNPIVRQKESELQMTSAASPHPGLLLDLKTSLEDAQVDDSIKSHVSYETEGFESASLDAELQKSDISQPSGPLLPELSKLGFPASLQRDLTRHISLKSKTGVHLPEPNLNSARRIRNISGHRKSETEKESGLKPTLRQILNASRRNVNWEQVIQQVTKKKQELGKGLPRFGIEMVPLVQNEQEALDLDGEPDLSSLEGFQWEGVSISSSPGLARKRSLSESSVIMDRAPSVYSFFSEEGTGKENEPQQMVSPSNSLRAGQSQKATMHLKQEVTPRAASLRTGERAENVATQRRHSAQLSSDHIIPLMHLAKDLNSQERSIPPSENQNSQESNGEGNCLSSSASSALAISSLADAATDSSCTSGAEQNDGQSIRKKRRATGDGSSPELPSLERKNKRRKIKGKKERSQVDQLLNISLREEELSKSLQCMDNNLLQARAALQTAYVEVQRLLMLKQQITMEMSALRTHRIQILQGLQETYEPSEHPDQVPCSLTRERRNSRSQTSIDAALLPTPFFPLFLEPPSSHVSPSPTGASLQITTSPTFQTHGSVPAPDSSVQIKQEPMSPEQDENVNAVPPSSACNVSKELLEANREISDSCPVYPVITARLSLPESTESFHEPSQELKFSVEQRNTRNRENSPSSQSAGLSSINKEGEEPTKGNSGSEACTSSFLRLSFASETPLEKEPHSPADQPEQQAESTLTSAETRGSKKKKKLRKKKSLRAAHVPENSDTEQDVLTVKPVRKVKAGKLIKGGKVTTSTWEDSRTGREQESVRDEPDSDSSLEVLEIPNPQLEVVAIDSSESGEEKPDSPSKKDIWNSTEQNPLETSRSGCDEVSSTSEIGTRYKDGIPVSVAETQTVISSIKGSKNSSEISSEPGDDDEPTEGSFEGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKNAALYTGSSDHTIRCYNVKSRECVEQLQLEDRVLCLHSRWRILYAGLANGTVVTFNIKNNKRLEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKSMIYTGCYDGSIQAVRLNLMQNYRCWWHGCSLIFGVVDHLKQHLLTDHTNPNFQTLKCRWKNCDAFFTARKGSKQDAAGHIERHAEDDSKIDS
Protein: O-acyltransferase
UniProt accession: Q9M4V2
Organism: Brassica napus
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, rosids, malvids, Brassicales, Brassicaceae, Brassiceae, Brassica
Gene names: DGAT1-4, DGAT1.a
Length: 501 residues
Disorder content (fraction disordered): 0.22554890219560875
Curated region start positions: 1, 1, 1, 1, 1, 1, 1, 1, 1
Curated region end positions: 80, 80, 80, 80, 80, 80, 113, 80, 80
Curated region terms: disorder, protein binding, disorder, disorder, disorder, disorder, disorder, small molecule binding, small molecule binding
Domain/feature annotations: MBOAT, membrane-bound O-acyltransferase family
Sequence:
MEILDSGGVTMPTENGGADLDTLRHRKPRSDSSNGLLPDSVTVSDADVRDRVDSAVEDTQGKANLAGENEIRESGGEAGGNVDVRYTYRPSVPAHRRVRESPLSSDAIFKQSHAGLFNLCVVVLVAVNSRLIIENLMKYGWLIRTDFWFSSTSLRDWPLFMCCLSLSIFPLAAFTVEKLVLQKCISEPVVIILHIIITMTEVLYPVYVTLRCDSAFLSGVTLMLLTCIVWLKLVSYAHTNYDIRTLANSSDKANPEVSYYVSLKSLAYFMLAPTLCYQPSYPRSPCIRKGWVARQFAKLIIFTGFMGFIIEQYINPIVRNSKHPLKGDLLYGVERVLKLSVPNLYVWLCMFYCFFHLWLNILAELLCFGDREFYKDWWNAKSVGDYWRMWNMPVHKWMVRHVYFPCLRRNIPKVPAIILAFLVSAVFHELCIAVPCRLFKLWAFLGIMFQVPLVFITNYLQERFGSMVGNMIFWFTFCIFGQPMCVLLYYHDLMNRKGKMS
Protein: Surfeit locus protein 6
UniProt accession: O75683
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SURF-6, SURF6
Length: 361 residues
Disorder content (fraction disordered): 0.5401662049861495
Dataset labels: Condensates-related proteins
Curated region start positions: 1, 1, 1
Curated region end positions: 182, 195, 182
Curated region terms: disorder, disorder, molecular condensate scaffold activity
Domain/feature annotations: Surfeit locus protein 6
Cross-references: EMDB:29252, EMDB:29253, EMDB:29254, EMDB:29255, PDB:8FKP, PDB:8FKQ, PDB:8FKR, PDB:8FKS
Sequence:
MASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERAGLV
Protein: C-C motif chemokine 28
UniProt accession: Q9NRJ3
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CCL28, SCYA28
Length: 127 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 99
Curated region end positions: 10, 108, 127
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: 2.40.50.40, Small cytokines (intecrine/chemokine), interleukin-8 like
Cross-references: PDB:6CWS
Sequence:
MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY
Protein: Dual-specificity RNA pseudouridine synthase RluF
UniProt accession: P32684
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW3982, b4022, rluF, yjbC
Length: 290 residues
Disorder content (fraction disordered): 0.1310344827586207
Curated region start positions: 253
Curated region end positions: 290
Curated region terms: disorder
Domain/feature annotations: Alpha-L RNA-binding motif, RNA-binding S4 domain, Pseudouridine synthase I, catalytic domain, N-terminal subdomain, RNA pseudouridylate synthase, S4 domain
Cross-references: PDB:3DH3
Sequence:
MLPDSSVRLNKYISESGICSRREADRYIEQGNVFLNGKRATIGDQVKPGDVVKVNGQLIEPREAEDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITEEFIRGMSAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNVSLSGIPLGEWRDLTDDELIDLFKLIENSSSEVKPKAKAKPKTAGIKRPVVKMEKTAEKGGRPASNGKRFTSPGRKKKGR
Protein: Low calcium response E
UniProt accession: Q9Z8L4
Organism: Chlamydia pneumoniae
Taxonomy: Bacteria, Chlamydiae, Chlamydiales, Chlamydiaceae, Chlamydia/Chlamydophila group, Chlamydia
Gene names: BN1224_CV15_B_02610, BN1224_DC9_BL_00250, BN1224_GiD_A_03370, BN1224_H12_DC_00070, BN1224_MUL2216_E_00610, BN1224_PB1_B_03230, BN1224_Panola_E_01460, BN1224_U1271_C_01640, BN1224_UZG1_A_03360, BN1224_Wien2_E_01090, BN1224_YK41_BG_00220, CP_0433, CPn_0324, CWL029c_C_01640, lcrE
Length: 399 residues
Disorder content (fraction disordered): 0.2781954887218045
Curated region start positions: 1, 384
Curated region end positions: 95, 399
Curated region terms: disorder, disorder
Domain/feature annotations: HrpJ-like domain, T3SS, Low calcium response E, third helical domain
Cross-references: PDB:4P40
Sequence:
MAASGGTGGLGGTQGVNLAAVEAAAAKADAAEVVASQEGSEMNMIQQSQDLTNPAAATRTKKKEEKFQTLESRKKGEAGKAEKKSESTEEKPDTDLADKYASGNSEISGQELRGLRDAIGDDASPEDILALVQEKIKDPALQSTALDYLVQTTPPSQGKLKEALIQARNTHTEQFGRTAIGAKNILFASQEYADQLNVSPSGLRSLYLEVTGDTHTCDQLLSMLQDRYTYQDMAIVSSFLMKGMATELKRQGPYVPSAQLQVLMTETRNLQAVLTSYDYFESRVPILLDSLKAEGIQTPSDLNFVKVAESYHKIINDKFPTASKVEREVRNLIGDDVDSVTGVLNLFFSALRQTSSRLFSSADKRQQLGAMIANALDAVNINNEDYPKASDFPKPYPWS
Protein: Calmodulin-1
UniProt accession: P0DP23
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CALM, CALM1, CAM, CAM1
Length: 149 residues
Disorder content (fraction disordered): 0.06711409395973154
Curated region start positions: 76, 76, 76
Curated region end positions: 85, 85, 85
Curated region terms: disorder, order to disorder, flexible linker
Domain/feature annotations: EF-hand, EF-hand, EF-hand, EF-hand domain pair, EF-hand domain pair
Cross-references: BMRB:34608, PDB:7NQC
Sequence:
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Protein: Heterogeneous nuclear ribonucleoprotein M
UniProt accession: P52272
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HNRNPM, HNRPM, NAGR1
Length: 730 residues
Disorder content (fraction disordered): 0.0410958904109589
Curated region start positions: 41, 41, 41
Curated region end positions: 70, 70, 70
Curated region terms: disorder, disorder to order, protein binding
Domain/feature annotations: 3.30.70.330, 3.30.70.330, 3.30.70.330, RNA recognition motif, RNA recognition motif, RNA recognition motif, HnRNP M nuclear localisation signal
Cross-references: PDB:2OT8
Sequence:
MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Protein: PE family protein
UniProt accession: A0A0H3LBR3
Organism: Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Taxonomy: Bacteria, Actinobacteria, Corynebacteriales, Mycobacteriaceae, Mycobacterium, Mycobacterium tuberculosis complex
Gene names: ERDMAN_2675, PE25
Length: 99 residues
Disorder content (fraction disordered): 0.101010101010101
Curated region start positions: 90
Curated region end positions: 99
Curated region terms: disorder
Domain/feature annotations: HP0062-like domain
Cross-references: PDB:4W4K
Sequence:
MSFVITNPEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTGADKYATAEADNIKTFS
Protein: Sphingomyelin phosphodiesterase
UniProt accession: P17405
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ASM, SMPD1
Length: 631 residues
Disorder content (fraction disordered): 0.08716323296354993
Dataset labels: NDDs-related proteins
Curated region start positions: 49, 614
Curated region end positions: 85, 631
Curated region terms: disorder, disorder
Domain/feature annotations: 3.60.21.10, Calcineurin-like phosphoesterase, Acid sphingomyelin phosphodiesterase C-terminal region
Cross-references: PDB:5I81
Sequence:
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC
Protein: Bifunctional protein PutA
UniProt accession: P09546
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW0999, b1014, poaA, putA
Length: 1320 residues
Disorder content (fraction disordered): 0.0893939393939394
Curated region start positions: 611, 185
Curated region end positions: 669, 243
Curated region terms: disorder, disorder
Domain/feature annotations: Single Helix bin, Aldehyde Dehydrogenase; Chain A, domain 2, Aldehyde Dehydrogenase; Chain A, domain 1, Met repressor-like, 3.20.20.220, Aldehyde dehydrogenase family, Proline dehydrogenase, DNA-binding domain of Proline dehydrogenase, Proline utilization A proline dehydrogenase N-terminal domain, PutA, RHH domain
Cross-references: PDB:1TIW, PDB:1TJ0, PDB:1TJ1, PDB:1TJ2
Sequence:
MGTTTMGVKLDDATRERIKSAATRIDRTPHWLIKQAIFSYLEQLENSDTLPELPALLSGAANESDEAPTPAEEPHQPFLDFAEQILPQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKATRDALIRDKISNGNWQSHIGRSPSLFVNAATWGLLFTGKLVSTHNEASLSRSLNRIIGKSGEPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGINIDAEESDRLEISLDLLEKLCFEPELAGWNGIGFVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLIYPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRDLYGHGRDNSAGLDLANEHRLASLSSALLNSALQKWQALPMLEQPVAAGEMSPVINPAEPKDIVGYVREATPREVEQALESAVNNAPIWFATPPAERAAILHRAAVLMESQMQQLIGILVREAGKTFSNAIAEVREAVDFLHYYAGQVRDDFANETHRPLGPVVCISPWNFPLAIFTGQIAAALAAGNSVLAKPAEQTPLIAAQGIAILLEAGVPPGVVQLLPGRGETVGAQLTGDDRVRGVMFTGSTEVATLLQRNIASRLDAQGRPIPLIAETGGMNAMIVDSSALTEQVVVDVLASAFDSAGQRCSALRVLCLQDEIADHTLKMLRGAMAECRMGNPGRLTTDIGPVIDSEAKANIERHIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVFGPVLHVVRYNRNQLPELIEQINASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVGAVVGVQPFGGEGLSGTGPKAGGPLYLYRLLANRPESALAVTLARQDAKYPVDAQLKAALTQPLNALREWAANRPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDEQDALTQLAAVLAVGSQVLWPDDALHRQLVKALPSAVSERIQLAKAENITAQPFDAVIFHGDSDQLRALCEAVAARDGTIVSVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTIG
Protein: Centromere DNA-binding protein complex CBF3 subunit A
UniProt accession: P32504
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: CBF2, CBF3A, CEP2, CTF14, NDC10, YGR140W
Length: 956 residues
Disorder content (fraction disordered): 0.5219665271966527
Curated region start positions: 1, 97, 168, 414, 538, 538, 552, 1
Curated region end positions: 43, 108, 182, 423, 551, 956, 956, 956
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, disorder, DNA binding
Domain/feature annotations: Centromere DNA-binding protein complex CBF3 subunit, domain 2, 1.10.150.130, Transcriptional activator of glycolytic enzymes, Centromere DNA-binding protein complex CBF3 subunit, domain 2, Ndc10 N-terminal domain
Cross-references: PDB:4ACO
Sequence:
MRSSILFLLKLMKIMDVQQQQEAMSSEDRFQELVDSLKPRTAHQYKTYYTKYIQWCQLNQIIPTPEDNSVNSVPYKDLPISAELIHWFLLDTLITDDKPGEKREETEDLDEEEENSFKIATLKKIIGSLNFLSKLCKVHENPNANIDTKYLESVTKLHTHWIDSQKAITTNETNNTNTQVLCPPLLKVSLNLWNPETNHLSEKFFKTCSEKLRFLVDFQLRSYLNLSFEERSKIRFGSLKLGKRDRDAIIYHKVTHSAEKKDTPGHHQLLALLPQDCPFICPQTTLAAYLYLRFYGIPSVSKGDGFPNLNADENGSLLQDIPILRGKSLTTYPREETFSNYYTTVFRYCHLPYKRREYFNKCNLVYPTWDEDTFRTFFNEENHGNWLEQPEAFAFPDKIPFDFKKIMNFKSPYTSYSTNAKKDPFPPPKDLLVQIFPEIDEYKRHDYEGLSQNSRDFLDLMEVLRERFLSNLPWIYKFFPNHDIFQDPIFGNSDFQSYFNDKTIHSKGSPILSFDILPGFNKIYKNKTNFYSLLIERPSQLTFASSHNPDTHPTQKQESEGPLQMSQLDTTQLNELLKQQSFEYVQFQTLSNFQILLSVFNKIFEKLEMKKSSRGYILHQLNLFKITLDERIKKSKIDDADKFIRDNQPIKKEENIVNEDGPNTSRRTKRPKQIRLLSIADSSDESSTEDSNVFKKDGESIEDGAYGENEDENDSEMQEQLKSMINELINSKISTFLRDQMDQFELKINALLDKILEEKVTRIIEQKLGSHTGKFSTLKRPQLYMTEEHNVGFDMEVPKKLRTSGKYAETVKDNDDHQAMSTTASPSPEQDQEAKSYTDEQEFMLDKSIDSIEGIILEWFTPNAKYANQCVHSMNKSGNKSWRANCEALYKERKSIVEFYIYLVNHESLDRYKAVDICEKLRDQNEGSFSRLAKFLRKWRHDHQNSFDGLLVYLSN
Protein: Histone H4
UniProt accession: P62805
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4
Length: 103 residues
Disorder content (fraction disordered): 0.24271844660194175
Dataset labels: Cancer-related proteins, NDDs-related proteins
Curated region start positions: 1
Curated region end positions: 25
Curated region terms: disorder
Domain/feature annotations: Histone, subunit A, Centromere kinetochore component CENP-T histone fold
Cross-references: BMRB:27457
Sequence:
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Protein: Tyrosine--tRNA ligase
UniProt accession: A6QHR2
Organism: Staphylococcus aureus (strain Newman)
Taxonomy: Bacteria, Firmicutes, Bacilli, Bacillales, Staphylococcaceae, Staphylococcus
Gene names: NWMN_1622, tyrS
Length: 420 residues
Disorder content (fraction disordered): 0.23333333333333336
Dataset labels: RNA-binding proteins
Curated region start positions: 323
Curated region end positions: 420
Curated region terms: disorder
Domain/feature annotations: HUPs, RNA-binding S4 domain, Tyrosyl-Transfer RNA Synthetase, tRNA synthetases class I (W and Y), Tyrosine--tRNA ligase SYY-like C-terminal domain
Cross-references: PDB:1JII
Sequence:
MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRFQEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQMHNIFEFGTDHGAVLVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGHLNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAVWLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLAEEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLIETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
Protein: Viral CASP8 and FADD-like apoptosis regulator
UniProt accession: Q98325
Organism: Molluscum contagiosum virus subtype 1
Taxonomy: Viruses, Varidnaviria, Bamfordvirae, Nucleocytoviricota, Pokkesviricetes, Chitovirales, Poxviridae, Chordopoxvirinae, Molluscipoxvirus
Gene names: H-H2.2, MC159L
Length: 241 residues
Disorder content (fraction disordered): 0.2074688796680498
Dataset labels: Viral proteins
Curated region start positions: 192, 214, 228, 211, 228, 214
Curated region end positions: 241, 218, 232, 241, 232, 218
Curated region terms: disorder, protein binding, protein binding, protein binding, negative regulation of apoptotic signaling pathway, negative regulation of apoptotic signaling pathway
Domain/feature annotations: Death Domain, Fas, Death Domain, Fas, Death effector domain
Cross-references: PDB:2BBZ
Sequence:
MSDSKEVPSLPFLRHLLEELDSHEDSLLLFLCHDAAPGCTTVTQALCSLSQQRKLTLAALVEMLYVLQRMDLLKSRFGLSKEGAEQLLGTSFLTRYRKLMVCVGEELDSSELRALRLFACNLNPSLSTALSESSRFVELVLALENVGLVSPSSVSVLADMLRTLRRLDLCQQLVEYEQQEQARYRYCYAASPSLPVRTLRRGHGASEHEQLCMPVQESSDSPELLRTPVQESSSDSPEQTT