LiteFold/DisProt huggingface dataset:
Protein: Tegument protein VP16
UniProt accession: P06492
Organism: Human herpesvirus 1 (strain 17)
Taxonomy: Viruses, Duplodnaviria, Heunggongvirae, Peploviricota, Herviviricetes, Herpesvirales, Herpesviridae, Alphaherpesvirinae, Simplexvirus
Gene names: UL48
Length: 490 residues
Disorder content (fraction disordered): 0.2714285714285714
Dataset labels: Viral proteins
Curated region start positions: 350, 403, 412, 412, 412, 412, 452, 452, 452, 452, 456, 456, 469, 469, 469, 469, 475, 475, 475, 412, 456, 456, 456, 412, 412, 412, 454, 412, 412, 350, 403
Curated region end positions: 394, 490, 490, 490, 490, 490, 490, 490, 490, 490, 490, 490, 485, 485, 485, 485, 484, 484, 484, 456, 490, 490, 490, 456, 490, 490, 490, 490, 490, 394, 412
Curated region terms: disorder, disorder, disorder, disorder, disorder to order, protein binding, disorder, protein binding, disorder to order, molecular function activator activity, disorder, protein binding, disorder, disorder to order, protein binding, molecular function activator activity, molecular function activator activity, disorder to order, protein binding, protein binding, protein binding, molecular function activator activity, molecular function activator activity, molecular function activator activity, protein binding, protein binding, protein binding, molecular function activator activity, molecular function activator activity, disorder, disorder
Domain/feature annotations: Alpha trans-inducing (Alpha-TIF), Alpha trans-inducing protein (Alpha-TIF), Herpes simplex virus virion protein 16 C terminal
Cross-references: BMRB:6099, PDB:16VP, PDB:2K2U, PDB:2PHE, PDB:2PHG
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
Protein: Heat shock factor-binding protein 1
UniProt accession: O75506
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HSBP1, HSF1BP
Length: 76 residues
Disorder content (fraction disordered): 0.35526315789473684
Curated region start positions: 1, 60, 60, 60, 60
Curated region end positions: 10, 76, 76, 76, 76
Curated region terms: disorder, disorder, protein binding, disorder, protein binding
Domain/feature annotations: 1.20.5.430, Heat shock factor binding protein 1
Sequence:
MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELESENKIPATQKS
Protein: Fibroblast growth factor 2
UniProt accession: P09038
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FGF2, FGFB
Length: 288 residues
Disorder content (fraction disordered): 0.0625
Dataset labels: Extracellular matrix proteins
Curated region start positions: 143
Curated region end positions: 160
Curated region terms: disorder
Domain/feature annotations: 2.80.10.50, Fibroblast growth factor
Cross-references: PDB:1BFG
Sequence:
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein: Zona pellucida sperm-binding protein 2
UniProt accession: P20239
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Zp-2, Zp2, Zpa
Length: 713 residues
Disorder content (fraction disordered): 0.030855539971949508
Curated region start positions: 463
Curated region end positions: 484
Curated region terms: disorder
Domain/feature annotations: Zona pellucida, ZP-N domain, Zona pellucida, ZP-C domain, ZP-C domain, ZP-N domain, Zona pellucida sperm-binding protein 2, Ig-like domain, Zona pellucida sperm-binding protein 2, Ig-like domain, Zona pellucida sperm-binding protein 2, Ig-like domain
Sequence:
MARWQRKASVSSPCGRSIYRFLSLLFTLVTSVNSVSLPQSENPAFPGTLICDKDEVRIEFSSRFDMEKWNPSVVDTLGSEILNCTYALDLERFVLKFPYETCTIKVVGGYQVNIRVGDTTTDVRYKDDMYHFFCPAIQAETHEISEIVVCRRDLISFSFPQLFSRLADENQNVSEMGWIVKIGNGTRAHILPLKDAIVQGFNLLIDSQKVTLHVPANATGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAPDLSVACNATHMTLTIPEFPGKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSEKCPFYQFYLSSLKLTFYFQGNMLSTVIDPECHCESPVSIDELCAQDGFMDFEVYSHQTKPALNLDTLLVGNSSCQPIFKVQSVGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIVFRNSEFRMTVRCYYIRDSMLLNAHVKGHPSPEAFVKPGPLVLVLQTYPDQSYQRPYRKDEYPLVRYLRQPIYMEVKVLSRNDPNIKLVLDDCWATSSEDPASAPQWQIVMDGCEYELDNYRTTFHPAGSSAAHSGHYQRFDVKTFAFVSEARGLSSLIYFHCSALICNQVSLDSPLCSVTCPASLRSKREANKEDTMTVSLPGPILLLSDVSSSKGVDPSSSEITKDIIAKDIASKTLGAVAALVGSAVILGFICYLYKKRTIRFNH
Protein: Tyrosine-protein phosphatase non-receptor type 7
UniProt accession: P35236
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PTPN7
Length: 360 residues
Disorder content (fraction disordered): 0.044444444444444446
Curated region start positions: 37, 37, 37
Curated region end positions: 52, 52, 52
Curated region terms: disorder, protein binding, disorder to order
Domain/feature annotations: Protein tyrosine phosphatase superfamily, Protein-tyrosine phosphatase
Cross-references: DIBS:DI1010079, PDB:2GPH
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
Protein: Mothers against decapentaplegic homolog 3
UniProt accession: P84022
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MADH3, SMAD3
Length: 425 residues
Disorder content (fraction disordered): 0.05176470588235294
Dataset labels: Cancer-related proteins, Condensates-related proteins
Curated region start positions: 1, 133
Curated region end positions: 10, 144
Curated region terms: disorder, disorder
Domain/feature annotations: SMAD MH1 domain, 2.60.200.10, MH1 domain, MH2 domain
Cross-references: PDB:1MHD, PDB:1OZJ
Sequence:
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
Protein: Histone H2B 5
UniProt accession: P0C1H4
Organism: Gallus gallus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Archelosauria, Archosauria, Dinosauria, Saurischia, Theropoda, Coelurosauria, Aves, Neognathae, Galloanserae, Galliformes, Phasianidae, Phasianinae, Gallus
Gene names: H2B-V
Length: 126 residues
Disorder content (fraction disordered): 0.2777777777777778
Curated region start positions: 1
Curated region end positions: 35
Curated region terms: disorder
Domain/feature annotations: Histone, subunit A, Core histone H2A/H2B/H3/H4 domain
Cross-references: PDB:2XQL
Sequence:
MPEPAKSAPAPKKGSKKAVTKTQKKGDKKRRKSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: 50S ribosomal protein L7/L12
UniProt accession: P0A7K2
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW3949, b3986, rplL
Length: 121 residues
Disorder content (fraction disordered): 0.09090909090909093
Curated region start positions: 33, 33
Curated region end positions: 43, 43
Curated region terms: disorder, flexible linker
Domain/feature annotations: 3.30.1390.10, Single helix bin, Ribosomal protein L7/L12 C-terminal domain, Ribosomal protein L7/L12 dimerisation domain
Cross-references: PDB:1RQU
Sequence:
MSITKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEVK
Protein: E3 ubiquitin-protein ligase UHRF1
UniProt accession: Q96T88
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ICBP90, NP95, RNF106, UHRF1
Length: 793 residues
Disorder content (fraction disordered): 0.09836065573770492
Curated region start positions: 165, 286, 286, 490, 490, 646, 646
Curated region end positions: 181, 301, 301, 501, 501, 678, 678
Curated region terms: disorder, disorder, phosphorylation display site, disorder, nucleic acid binding, disorder, protein binding
Domain/feature annotations: Zinc/RING finger domain, C3HC4 (zinc finger), SRA-YDG, 2.30.30.1150, 2.30.30.140, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1, Ubiquitin family, PHD-finger, SAD/SRA domain, Tandem tudor domain within UHRF1
Cross-references: PDB:2L3R, PDB:3BI7, PDB:5C6D
Sequence:
MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKSSTHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR
Protein: Diphthamide biosynthesis protein 3
UniProt accession: Q3E840
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: DPH3, KTI11, YBL071W-A
Length: 82 residues
Disorder content (fraction disordered): 0.15853658536585366
Curated region start positions: 70
Curated region end positions: 82
Curated region terms: disorder
Domain/feature annotations: DPH Zinc finger, CSL zinc finger
Cross-references: PDB:1YOP
Sequence:
MSTYDEIEIEDMTFEPENQMFTYPCPCGDRFQIYLDDMFEGEKVAVCPSCSLMIDVVFDKEDLAEYYEEAGIHPPEPIAAAA
Protein: 60S ribosomal protein L4
UniProt accession: P36578
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: RPL1, RPL4
Length: 427 residues
Disorder content (fraction disordered): 0.3091334894613583
Curated region start positions: 46, 80, 301, 369
Curated region end positions: 63, 114, 320, 427
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: 3.40.1370.10, Ribosomal protein L4/L1 family, 60S ribosomal protein L4 C-terminal domain
Cross-references: PDB:5LKS
Sequence:
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAALQAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTTEEKKPAA
Protein: Coatomer subunit delta
UniProt accession: Q5XJY5
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Arcn1, Copd
Length: 511 residues
Disorder content (fraction disordered): 0.1643835616438356
Curated region start positions: 166, 245
Curated region end positions: 232, 261
Curated region terms: disorder, disorder
Domain/feature annotations: Mu homology domain, subdomain B, Mu homology domain, subdomain B, 3.30.450.60, Adaptor complexes medium subunit family, Clathrin adaptor complex small chain
Cross-references: EMDB:EMD-3720, EMDB:EMD-3721, EMDB:EMD-3722, EMDB:EMD-3723, EMDB:EMD-3724, PDB:5NZR, PDB:5NZS, PDB:5NZT, PDB:5NZU, PDB:5NZV
Sequence:
MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKAPGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGPSKALKLGAKGKEVDNFVDKLKSEGETIMSSNMGKRTSEATKVHAPPINMESVHMKIEEKITLTCGRDGGLQNMELHGMIMLRISDDKFGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTEESFIPLTINCWPSESGNGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIPGQPNDFFPVQVSFISKKNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL
Protein: Pre-mRNA-processing protein 45
UniProt accession: Q09882
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Taphrinomycotina, Schizosaccharomycetes, Schizosaccharomycetales, Schizosaccharomycetaceae, Schizosaccharomyces
Gene names: SPCC188.11, SPCC584.08, cwf13, prp45, snw1
Length: 557 residues
Disorder content (fraction disordered): 0.6122082585278277
Curated region start positions: 316, 1, 100, 100, 100, 100
Curated region end positions: 557, 99, 315, 315, 315, 315
Curated region terms: disorder, disorder, disorder to order, RNA binding, protein binding, molecular adaptor activity
Domain/feature annotations: SKIP/SNW domain
Cross-references: PDB:3JB9
Sequence:
MALLSEELSSILPNPDFDDEEEDYVERETSHADERQIGVKFHIPPYGQRKGWFPSSPEDFGDGGAFPEIHVAQYPLDMGRKRSAKSAGNTLALQVTSSGAVDYNAIARQGHEHGELVQASFRDLIPLRARLGVGEISLEKPSDEQKQEVANKTKLALQKILSKQIAQSQPKSAVVQQRDDPVYIRYTPSNQMGQALSKQRIIKMVTAEQDPMEPPKFRHKKVPRGPPSPPPPVLHSPPRKVSAQEQQDWQIPPSISNWKNPKGYTIPLDKRLAADGRGLNDVEINDGFAKFSEALYTVERQAREEVRYRAIMRQKMAEKEKQEKEQRLFMLAQKAREDRMGRNAASSGPSHAKPRSTSVSSEERSRSRAGSFSHHSESENEDEDSEAFRRRQELRRERRRQAEKDLRLSRMGAEKRAKLAEKDRPRDVAERVALGLSKPSMSSDTMIDSRLFNQASGLGSGFQDEDSYNVYDKPWRAAPSSTLYRPGATLSRQVDASAELERITSESRYDVLGNAHKKFKGSDEVVESRAGPVTFEKDIADPFGVDTFLNNVSSKKT
Protein: Caltractin
UniProt accession: P05434
Organism: Chlamydomonas reinhardtii
Taxonomy: Eukaryota, Viridiplantae, Chlorophyta, core chlorophytes, Chlorophyceae, CS clade, Chlamydomonadales, Chlamydomonadaceae, Chlamydomonas
Length: 169 residues
Disorder content (fraction disordered): 0.13609467455621302
Curated region start positions: 1
Curated region end positions: 23
Curated region terms: disorder
Domain/feature annotations: EF-hand, EF-hand, EF-hand, EF-hand domain pair, EF-hand domain pair
Cross-references: BMRB:6820, PDB:2AMI
Sequence:
MSYKAKTVVSARRDQKKGRVGLTEEQKQEIREAFDLFDTDGSGTIDAKELKVAMRALGFEPKKEEIKKMISEIDKDGSGTIDFEEFLTMMTAKMGERDSREEILKAFRLFDDDNSGTITIKDLRRVAKELGENLTEEELQEMIAEADRNDDNEIDEDEFIRIMKKTSLF
Protein: Oxygen-evolving enhancer protein 3, chloroplastic
UniProt accession: P12301
Organism: Spinacia oleracea
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, Caryophyllales, Chenopodiaceae, Chenopodioideae, Anserineae, Spinacia
Gene names: PSBQ
Length: 232 residues
Disorder content (fraction disordered): 0.5129310344827587
Curated region start positions: 97, 84, 1
Curated region end positions: 116, 119, 83
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle, Oxygen evolving enhancer protein 3
Cross-references: BMRB:25350, EMDB:EMD-6617, PDB:1VYK, PDB:2MWQ, PDB:3JCU
Sequence:
MAQAMASMAGLRGASQAVLEGSLQISGSNRLSGPTTSRVAVPKMGLNIRAQQVSAEAETSRRAMLGFVAAGLASGSFVKAVLAEARPIVVGPPPPLSGGLPGTENSDQARDGTLPYTKDRFYLQPLPPTEAAQRAKVSASEILNVKQFIDRKAWPSLQNDLRLRASYLRYDLKTVISAKPKDEKKSLQELTSKLFSSIDNLDHAAKIKSPTEAEKYYGQTVSNINEVLAKLG
Protein: BH3-interacting domain death agonist
UniProt accession: P70444
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Bid
Length: 195 residues
Disorder content (fraction disordered): 0.21025641025641023
Curated region start positions: 41, 41
Curated region end positions: 81, 81
Curated region terms: disorder, flexible linker
Domain/feature annotations: Blc2-like, BH3 interacting domain (BID)
Cross-references: PDB:1DDB
Sequence:
MDSEVSNGSGLGAEHITDLLVFGFLQSSGCTRQELEVLGRELPVQAYWEADLEDELQTDGSQASRSFNQGRIEPDSESQEEIIHNIARHLAQIGDEMDHNIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTAFPRDMENDKAMLIMTMLLAKKVASHAPSLLRDVFHTTVNFINQNLFSYVRNLVRNEMD
Protein: Major prion protein homolog
UniProt accession: P27177
Organism: Gallus gallus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Archelosauria, Archosauria, Dinosauria, Saurischia, Theropoda, Coelurosauria, Aves, Neognathae, Galloanserae, Galliformes, Phasianidae, Phasianinae, Gallus
Gene names: PRN-P, PRNP
Length: 273 residues
Disorder content (fraction disordered): 0.46886446886446886
Curated region start positions: 25, 200, 200
Curated region end positions: 134, 217, 217
Curated region terms: disorder, disorder, flexible linker
Domain/feature annotations: Prion/Doppel protein, beta-ribbon domain, Prion/Doppel alpha-helical domain
Cross-references: PDB:1U3M
Sequence:
MARLLTTCCLLALLLAACTDVALSKKGKGKPSGGGWGAGSHRQPSYPRQPGYPHNPGYPHNPGYPHNPGYPHNPGYPHNPGYPQNPGYPHNPGYPGWGQGYNPSSGGSYHNQKPWKPPKTNFKHVAGAAAAGAVVGGLGGYAMGRVMSGMNYHFDSPDEYRWWSENSARYPNRVYYRDYSSPVPQDVFVADCFNITVTEYSIGPAAKKNTSEAVAAANQTEVEMENKVVTKVIREMCVQQYREYRLASGIQLHPADTWLAVLLLLLTTLFAMH
Protein: Prion protein
UniProt accession: Q9I9C0
Organism: Trachemys scripta
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Archelosauria, Testudines, Cryptodira, Durocryptodira, Testudinoidea, Emydidae, Trachemys
Gene names: prnp
Length: 270 residues
Disorder content (fraction disordered): 0.43703703703703706
Curated region start positions: 25
Curated region end positions: 142
Curated region terms: disorder
Domain/feature annotations: Prion/Doppel protein, beta-ribbon domain, Prion/Doppel alpha-helical domain, Major prion protein bPrPp - N terminal
Cross-references: PDB:1U5L
Sequence:
MGRYRLTCWIVVLLVVMWSDVSFSKKGKGKGGGGGNTGSNRNPNYPSNPGYPQNPGYPRNPSYPHNPAYPPNPAYPPNPGYPHNPSYPRNPSYPQNPGYPGGGGQHYNPAGGGTNFKNQKPWKPDKPKTNMKAMAGAAAAGAVVGGLGGYALGSAMSGMRMNFDRPEERQWWNENSNRYPNQVYYKEYNDRSVPEGRFVRDCLNNTVTEYKIDPNENQNVTQVEVRVMKQVIQEMCMQQYQQYQLASGVKLLSDPSLMLIIMLVIFFVMH
Protein: Prion protein
UniProt accession: Q5S1W7
Organism: Xenopus laevis
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Amphibia, Batrachia, Anura, Pipoidea, Pipidae, Xenopodinae, Xenopus, Xenopus
Length: 171 residues
Disorder content (fraction disordered): 0.40350877192982454
Curated region start positions: 1
Curated region end positions: 69
Curated region terms: disorder
Domain/feature annotations: Prion/Doppel protein, beta-ribbon domain, Prion/Doppel alpha-helical domain
Cross-references: PDB:1XU0
Sequence:
KKSGGGKSKTGGWNTGSNRNPNYPGGYPGNTGGSWGQQPYNPSGYNKQWKPPKSKTNMKSVAIGAAAGAIGGYMLGNAVGRMSYQFNNPMESRYYNDYYNQMPNRVYRPMYRGEEYVSEDRFVRDCYNMSVTEYIIKPAEGKNNSELNQLDTTVKSQIIREMCITEYRRGS
Protein: Nuclear transcription factor RelA
UniProt accession: Q548Y4
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Rela
Length: 549 residues
Disorder content (fraction disordered): 0.11839708561020036
Curated region start positions: 426, 426
Curated region end positions: 490, 490
Curated region terms: disorder, protein binding
Domain/feature annotations: Rel homology domain (RHD), DNA-binding domain, Immunoglobulins, Rel homology DNA-binding domain, Rel homology dimerisation domain
Sequence:
MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
Protein: Histidine--tRNA ligase, cytoplasmic
UniProt accession: P12081
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HARS, HARS1, HRS
Length: 509 residues
Disorder content (fraction disordered): 0.12573673870333987
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 344, 1
Curated region end positions: 355, 52
Curated region terms: disorder, disorder
Domain/feature annotations: Anticodon-binding domain, S15/NS1, RNA-binding, Bira Bifunctional Protein; Domain 2, WHEP-TRS domain, Anticodon binding domain, Histidyl-tRNA synthetase
Cross-references: PDB:4PHC
Sequence:
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC
Protein: Flagellar calcium-binding protein TB-24
UniProt accession: Q26680
Organism: Trypanosoma brucei brucei
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Trypanosoma
Length: 218 residues
Disorder content (fraction disordered): 0.1743119266055046
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1, 206
Curated region end positions: 25, 218
Curated region terms: disorder, disorder
Domain/feature annotations: EF-hand, EF-hand domain pair, FCaBP EF-hand domain
Cross-references: PDB:2LVV
Sequence:
MGCSASKDTTNSKDGAASKGGKDGKTTADRKVAWERIRCAIPRDKDAESKSRRIELFKQFDTNGTGKLGFREVLDGCYGILKLDEFTTHLPDIVQRAFDKAKDLGNKVKGVGEEDLVEFLEFRLMLCYIYDIFELTVMFDTMDKDGSLLLELQEFKEALPKLKEWGVDITDATTVFNEIDTNGSGVVTFDEFSCWAVTKKLQVCGDPDGEENGANEGN