LiteFold/DisProt huggingface dataset:
Protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
UniProt accession: P10688
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Plcd1
Length: 756 residues
Disorder content (fraction disordered): 0.08333333333333333
Curated region start positions: 133, 446
Curated region end positions: 157, 483
Curated region terms: disorder, disorder
Domain/feature annotations: C2 domain, Phosphatidylinositol (PI) phosphodiesterase, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), EF-hand, EF-hand, C2 domain, Phosphatidylinositol-specific phospholipase C, Y domain, Phosphatidylinositol-specific phospholipase C, X domain, Phosphoinositide-specific phospholipase C, efhand-like, Pleckstrin homology domain
Cross-references: PDB:1DJW, PDB:1DJX, PDB:1DJY, PDB:1DJZ
Sequence:
MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD
Protein: Sperm histone
UniProt accession: P15340
Organism: Gallus gallus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Archelosauria, Archosauria, Dinosauria, Saurischia, Theropoda, Coelurosauria, Aves, Neognathae, Galloanserae, Galliformes, Phasianidae, Phasianinae, Gallus
Length: 62 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 62, 62, 62, 62
Curated region terms: disorder, disorder to order, carboxylic acid binding, DNA binding
Sequence:
MARYRRSRTRSRSPRSRRRRRRSGRRRSPRRRRRYGSARRSRRSVGGRRRRYGSRRRRRRRY
Protein: Modification methylase PvuII
UniProt accession: P11409
Organism: Proteus hauseri
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Morganellaceae, Proteus
Gene names: pvuIIM
Length: 336 residues
Disorder content (fraction disordered): 0.1130952380952381
Curated region start positions: 179
Curated region end positions: 216
Curated region terms: disorder
Domain/feature annotations: DNA methylase
Cross-references: PDB:1BOO
Sequence:
MMTLNLQTMSSNDMLNFGKKPAYTTSNGSMYIGDSLELLESFPDESISLVMTSPPFALQRKKEYGNLEQHEYVDWFLSFAKVVNKKLKPDGSFVVDFGGAYMKGVPARSIYNFRVLIRMIDEVGFFLAEDFYWFNPSKLPSPIEWVNKRKIRVKDAVNTVWWFSKTEWPKSDITKVLAPYSDRMKKLIEDPDKFYTPKTRPSGHDIGKSFSKDNGGSIPPNLLQISNSESNGQYLANCKLMGIKAHPARFPAKLPEFFIRMLTEPDDLVVDIFGGSNTTGLVAERESRKWISFEMKPEYVAASAFRFLDNNISEEKITDIYNRILNGESLDLNSII
Protein: Retinoic acid receptor RXR-alpha
UniProt accession: P19793
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NR2B1, RXRA
Length: 462 residues
Disorder content (fraction disordered): 0.3268398268398268
Curated region start positions: 1, 1, 178, 178, 169
Curated region end positions: 130, 130, 187, 187, 189
Curated region terms: disorder, disorder, disorder, zinc ion binding, disorder
Domain/feature annotations: Erythroid Transcription Factor GATA-1, subunit A, Retinoid X Receptor, Ligand-binding domain of nuclear hormone receptor, Double treble clef zinc finger, C4 type, Nuclear/hormone receptor activator site AF-1
Cross-references: PDB:1RXR
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
Protein: Regulator of G-protein signaling 4
UniProt accession: P49799
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Rgs4
Length: 205 residues
Disorder content (fraction disordered): 0.375609756097561
Curated region start positions: 1, 179
Curated region end positions: 50, 205
Curated region terms: disorder, disorder
Domain/feature annotations: 1.10.196.10, 1.10.196.10, Regulator of G-protein Signalling 4, domain 2, Regulator of G protein signaling domain
Cross-references: PDB:1AGR
Sequence:
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDKVVTCQRVSQEEVKKWAESLENLINHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLTNPSSCGAEKQKGAKSSADCTSLVPQCA
Protein: Capsid protein
UniProt accession: P03607
Organism: Southern cowpea mosaic virus
Taxonomy: Viruses, Riboviria, Orthornavirae, Pisuviricota, Pisoniviricetes, Sobelivirales, Solemoviridae, Sobemovirus
Gene names: ORF3
Length: 279 residues
Disorder content (fraction disordered): 0.13620071684587814
Dataset labels: Viral proteins
Curated region start positions: 20
Curated region end positions: 57
Curated region terms: disorder
Domain/feature annotations: 2.60.120.20, Viral coat protein (S domain)
Cross-references: PDB:4SBV
Sequence:
MSGLFHHRTKPREIRAFVMATRLTKKQLAQAIQNTLPNPPRRKRRAKRRAAQVPKPTQAGVSMAPIAQGTMVKLRPPMLRSSMDVTILSHCELSTELAVTVTIVVTSELVMPFTVGTWLRGVAQNWSKYAWVAIRYTYLPSCPTTTSGAIHMGFQYDMADTLPVSVNQLSNLKGYVTGPVWEGQSGLCFVNNTKCPDTSRAITIALDTNEVSEKRYPFKTATDYATAVGVNANIGNILVPARLVTAMEGGSSKTAVNTGRLYASYTIRLIEPIAAALNL
Protein: Serine-aspartate repeat-containing protein D
UniProt accession: O86488
Organism: Staphylococcus aureus (strain Newman)
Taxonomy: Bacteria, Firmicutes, Bacilli, Bacillales, Staphylococcaceae, Staphylococcus
Gene names: NWMN_0524, sdrD
Length: 1315 residues
Disorder content (fraction disordered): 0.5186311787072243
Curated region start positions: 569, 569, 569, 569, 569, 569, 569, 569, 569, 569, 569, 1117
Curated region end positions: 1123, 1123, 1123, 1123, 1123, 1123, 1123, 1123, 1123, 1123, 1123, 1250
Curated region terms: disorder, calcium ion binding, disorder, disorder to order, calcium ion binding, disorder, disorder to order, calcium ion binding, disorder, disorder to order, calcium ion binding, disorder
Domain/feature annotations: Immunoglobulins, Immunoglobulins, Immunoglobulins, 2.60.40.1280, Immunoglobulins, Immunoglobulins, 2.60.40.1290, LPXTG cell wall anchor motif, YSIRK type signal peptide, C-terminus of bacterial fibrinogen-binding adhesin, SdrD B-like domain, SdrD B-like domain, SdrD B-like domain, SdrD B-like domain, SdrD B-like domain, Bacterial Ig domain
Sequence:
MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKELNEATTSASDNQSSDKVDMQQLNQEDNTKNDNQKEMVSSQGNETTSNGNKLIEKESVQSTTGNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEALQPDLQENKSVVNVQPTNEENKKVDAKTESTTLNVKSDAIKSNDETLVDNNSNSNNENNADIILPKSTAPKRLNTRMRIAAVQPSSTEAKNVNDLITSNTTLTVVDADKNNKIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIKNIGDIKDPNNGETIATAKHDTANNLITYTFTDYVDRFNSVQMGINYSIYMDADTIPVSKNDVEFNVTIGNTTTKTTANIQYPDYVVNEKNSIGSAFTETVSHVGNKENPGYYKQTIYVNPSENSLTNAKLKVQAYHSSYPNNIGQINKDVTDIKIYQVPKGYTLNKGYDVNTKELTDVTNQYLQKITYGDNNSAVIDFGNADSAYVVMVNTKFQYTNSESPTLVQMATLSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTVFDNNTNTKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNEELDSNGLSSVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVWEDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGTSTTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVTLLNEKGEVIGTTKTDENGKYCFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDRDSDSDSDSDSDSDSDSDSDSDSDSDSDSDRDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGNENSGSNNATLFGGLFAALGSLLLFGRRKKQNK
Protein: Small heat shock protein HSP16.5
UniProt accession: Q57733
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Taxonomy: Archaea, Euryarchaeota, Methanomada group, Methanococci, Methanococcales, Methanocaldococcaceae, Methanocaldococcus
Gene names: MJ0285
Length: 147 residues
Disorder content (fraction disordered): 0.22448979591836735
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 32, 32, 33, 33
Curated region terms: disorder, flexible N-terminal tail, disorder, flexible N-terminal tail
Domain/feature annotations: 2.60.40.790, Hsp20/alpha crystallin family
Cross-references: PDB:1SHS, PDB:4I88
Sequence:
MFGRDPFDSLFERMFKEFFATPMTGTTMIQSSTGIQISGKGFMPISIIEGDQHIKVIAWLPGVNKEDIILNAVGDTLEIRAKRSPLMITESERIIYSEIPEEEEIYRTIKLPATVKEENASAKFENGVLSVILPKAESSIKKGINIE
Protein: Synaptosomal-associated protein 25
UniProt accession: P60881
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Snap, Snap25
Length: 206 residues
Disorder content (fraction disordered): 0.9951456310679612
Curated region start positions: 120, 2, 2, 2, 84, 2
Curated region end positions: 206, 83, 83, 83, 119, 83
Curated region terms: disorder, protein binding, protein binding, disorder to order, disorder, disorder
Domain/feature annotations: 1.20.5.110, 1.20.5.110, SNAP-25 family
Sequence:
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
Protein: Vesicle-associated membrane protein 2
UniProt accession: P63027
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SYB2, VAMP2
Length: 116 residues
Disorder content (fraction disordered): 0.2413793103448276
Dataset labels: NDDs-related proteins
Curated region start positions: 40, 40
Curated region end positions: 67, 67
Curated region terms: disorder, disorder to order
Domain/feature annotations: 1.20.5.110, Synaptobrevin
Sequence:
MSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST
Protein: Alpha-synuclein
UniProt accession: P37840
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NACP, PARK1, SNCA
Length: 140 residues
Disorder content (fraction disordered): 1
Dataset labels: Condensates-related proteins, Age-related disorders proteins
Curated region start positions: 1, 100, 1, 1, 42, 42, 42, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 61, 1, 1, 1, 101
Curated region end positions: 140, 140, 140, 140, 92, 92, 92, 140, 140, 140, 140, 102, 102, 140, 140, 140, 140, 95, 102, 102, 103, 140
Curated region terms: disorder, disorder, disorder, lipid binding, disorder, disorder to order, lipid binding, disorder, disorder to order, tubulin binding, disorder, disorder to order, lipid binding, disorder, disorder, disorder, disorder, amyloid fibril formation, lipid binding, disorder to order, disorder, disorder
Domain/feature annotations: Helix hairpin bin, Synuclein
Cross-references: PDB:2KKW
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Protein: Homeobox protein Nkx-2.1
UniProt accession: P23441
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Nkx-2.1, Nkx2-1, Titf1, Ttf-1, Ttf1
Length: 372 residues
Disorder content (fraction disordered): 0.41935483870967744
Curated region start positions: 1, 1, 58, 1, 1, 1
Curated region end positions: 156, 156, 78, 156, 156, 156
Curated region terms: disorder, disorder to order, disorder to order, disorder, transcription coactivator activity, protein binding
Domain/feature annotations: Homeodomain-like, Homeodomain
Sequence:
MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW
Protein: Thymidylate synthase
UniProt accession: P04818
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: OK/SW-cl.29, TS, TYMS
Length: 313 residues
Disorder content (fraction disordered): 0.15654952076677317
Curated region start positions: 1, 107, 1, 117
Curated region end positions: 25, 128, 27, 128
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Thymidylate synthase/dCMP hydroxymethylase domain, Thymidylate synthase
Cross-references: PDB:1HW3, PDB:1HW4
Sequence:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
Protein: Estrogen receptor
UniProt accession: P03372
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ESR, ESR1, NR3A1
Length: 595 residues
Disorder content (fraction disordered): 0.39663865546218485
Dataset labels: Cancer-related proteins, Condensates-related proteins
Curated region start positions: 1, 1, 1, 214, 253, 1, 287, 287, 287, 300, 300, 1, 301, 301
Curated region end positions: 184, 184, 184, 236, 262, 184, 305, 305, 305, 304, 305, 180, 305, 305
Curated region terms: disorder, disorder to order, disorder, disorder, disorder, TBP-class protein binding, disorder, disorder to order, calmodulin binding, methylation display site, methylation display site, 14-3-3 protein binding, acetylation display site, phosphorylation display site
Domain/feature annotations: Retinoid X Receptor, Erythroid Transcription Factor GATA-1, subunit A, Ligand-binding domain of nuclear hormone receptor, Double treble clef zinc finger, C4 type, Oestrogen receptor, Oestrogen-type nuclear receptor final C-terminal
Cross-references: PDB:1HCP, PDB:2LLO, PDB:2LLQ
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Protein: DNA topoisomerase 1
UniProt accession: P11387
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TOP1
Length: 765 residues
Disorder content (fraction disordered): 0.4
Dataset labels: Cancer-related proteins, Condensates-related proteins
Curated region start positions: 1, 652, 636, 636, 175, 628, 1, 1, 1, 1, 1, 1, 1
Curated region end positions: 174, 696, 712, 712, 214, 719, 174, 174, 174, 214, 214, 214, 214
Curated region terms: disorder, disorder, disorder, flexible linker, disorder, disorder, disorder, DNA binding, bending, DNA binding, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity
Domain/feature annotations: Topoisomerase I; Chain A, domain 3, 1.10.132.10, Yeast DNA topoisomerase - domain 1, DNA Topoisomerase I, domain 2, Eukaryotic DNA topoisomerase I, catalytic core, Eukaryotic DNA topoisomerase I, DNA binding fragment, C-terminal topoisomerase domain
Cross-references: PDB:1A31, PDB:1A35
Sequence:
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
Protein: DNA topoisomerase 2
UniProt accession: P06786
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: N2244, TOP2, TOR3, YNL088W
Length: 1428 residues
Disorder content (fraction disordered): 0.09733893557422968
Curated region start positions: 632, 660, 1072, 1179, 1071, 259, 409, 1077, 1178, 633, 409, 259, 409
Curated region end positions: 652, 674, 1106, 1201, 1106, 274, 418, 1106, 1201, 681, 420, 275, 418
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: 3.40.50.670, 3.30.230.10, Histidine kinase-like ATPase, C-terminal domain, 3.30.1490.30, DNA gyrase B, DNA gyrase/topoisomerase IV, subunit A, Toprim domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, C-terminal associated domain of TOPRIM
Cross-references: PDB:1BGW, PDB:1BJT, PDB:1QZR, PDB:4GFH
Sequence:
MSTEPVSASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRFGMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLKSLEKKRQLDNGEDGAAKSDIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQIVKKISEILKKKKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGSRCEIPLEYINKIMKTDLATRMFEIADANEENALKKSDGTRKSRITNYPKLEDANKAGTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYEKWREEESHKFTWKQKYYKGLGTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQYEPGTVLDPTLKEIPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDNIKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKLSAKDIWNTDLKAFEVGYQEFLQRDAEARGGNVPNKGSKTKGKGKRKLVDDEDYDPSKKNKKSTARKGKKIKLEDKNFERILLEQKLVTKSKAPTKIKKEKTPSVSETKTEEEENAPSSTSSSSIFDIKKEDKDEGELSKISNKFKKISTIFDKMGSTSATSKENTPEQDDVATKKNQTTAKKTAVKPKLAKKPVRKQQKVVELSGESDLEILDSYTDREDSNKDEDDAIPQRSRRQRSSRAASVPKKSYVETLELSDDSFIEDDEEENQGSDVSFNEED
Protein: Regulatory protein ADR1
UniProt accession: P07248
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: ADR1, YD8142.16, YD8142B.08, YDR216W
Length: 1323 residues
Disorder content (fraction disordered): 0.021919879062736205
Curated region start positions: 75, 75, 75, 75, 84, 84, 84, 86, 86, 86
Curated region end positions: 103, 103, 103, 103, 102, 102, 102, 102, 102, 102
Curated region terms: disorder, molecular adaptor activity, nucleic acid binding, disorder to order, disorder, nucleic acid binding, disorder to order, disorder, disorder to order, nucleic acid binding
Domain/feature annotations: Classic Zinc Finger, Classic Zinc Finger, Zinc finger, C2H2 type, Zinc finger, C2H2 type
Cross-references: PDB:2ADR
Sequence:
MANVEKPNDCSGFPVVDLNSCFSNGFNNEKQEIEMETDDSPILLMSSSASRENSNTFSVIQRTPDGKIITTNNNMNSKINKQLDKLPENLRLNGRTPSGKLRSFVCEVCTRAFARQEHLKRHYRSHTNEKPYPCGLCNRCFTRRDLLIRHAQKIHSGNLGETISHTKKVSRTITKARKNSASSVKFQTPTYGTPDNGNFLNRTTANTRRKASPEANVKRKYLKKLTRRASFSAQSASSYALPDQSSLEQHPKDRVKFSTPELVPLDLKNPELDSSFDLNMNLDLNLNLDSNFNIALNRSDSSGSTMNLDYKLPESANNYTYSSGSPTRAYVGANTNSKNASFNDADLLSSSYWIKAYNDHLFSVSESDETSPMNSELNDTKLIVPDFKSTIHHLKDSRSSSWTVAIDNNSNNNKVSDNQPDFVDFQELLDNDTLGNDLLETTAVLKEFELLHDDSVSATATSNEIDLSHLNLSNSPISPHKLIYKNKEGTNDDMLISFGLDHPSNREDDLDKLCNMTRDVQAIFSQYLKGEESKRSLEDFLSTSNRKEKPDSGNYTFYGLDCLTLSKISRALPASTVNNNQPSHSIESKLFNEPMRNMCIKVLRYYEKFSHDSSESVMDSNPNLLSKELLMPAVSELNEYLDLFKNNFLPHFPIIHPSLLDLDLDSLQRYTNEDGYDDAENAQLFDRLSQGTDKEYDYEHYQILSISKIVCLPLFMATFGSLHKFGYKSQTIELYEMSRRILHSFLETKRRCRSTTVNDSYQNIWLMQSLILSFMFALVADYLEKIDSSLMKRQLSALCSTIRSNCLPTISANSEKSINNNNEPLTFGSPLQYIIFESKIRCTLMAYDFCQFLKCFFHIKFDLSIKEKDVETIYIPDNESKWASESIICNGHVVQKQNFYDFRNFYYSFTYGHLHSIPEFLGSSMIYYEYDLRKGTKSHVFLDRIDTKRLERSLDTSSYGNDNMAATNKNIAILIDDTIILKNNLMSMRFIKQIDRSFTEKVRKGQIAKIYDSFLNSVRLNFLKNYSVEVLCEFLVALNFSIRNISSLYVEEESDCSQRMNSPELPRIHLNNQALSVFNLQGYYYCFILIIKFLLDFEATPNFKLLRIFIELRSLANSILLPTLSRLYPQEFSGFPDVVFTQQFINKDNGMLVPGLSANEHHNGASAAVKTKLAKKINVEGLAMFINEILVNSFNDTSFLNMEDPIRNEFSFDNGDRAVTDLPRSAHFLSDTGLEGINFSGLNDSHQTVSTLNLLRYGENHSSKHKNGGKGQGFAEKYQLSLKYVTIAKLFFTNVKENYIHCHMLDKMASDFHTLENHLKGNS
Protein: Proto-oncogene c-Fos
UniProt accession: P01100
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FOS, G0S7
Length: 380 residues
Disorder content (fraction disordered): 0.4342105263157895
Dataset labels: Autophagy-related proteins
Curated region start positions: 216, 216, 216
Curated region end positions: 380, 380, 380
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: 1.20.5.170, bZIP transcription factor
Sequence:
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL