LiteFold/DisProt huggingface dataset:
Protein: Snurportin-1
UniProt accession: O95149
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: RNUT1, SNUPN, SPN1
Length: 360 residues
Disorder content (fraction disordered): 0.225
Curated region start positions: 288, 72
Curated region end positions: 348, 91
Curated region terms: disorder, disorder
Domain/feature annotations: DNA ligase/mRNA capping enzyme, Snurportin1, Snurportin1, m3G cap-binding domain
Cross-references: PDB:3GJX
Sequence:
MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN
Protein: 120 kDa immunodominant surface protein
UniProt accession: Q2GI62
Organism: Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Taxonomy: Bacteria, Proteobacteria, Alphaproteobacteria, Rickettsiales, Anaplasmataceae, Ehrlichia
Gene names: ECH_0039
Length: 548 residues
Disorder content (fraction disordered): 0.145985401459854
Curated region start positions: 142, 142, 142, 142
Curated region end positions: 221, 221, 221, 221
Curated region terms: disorder, nucleic acid binding, disorder, disorder
Domain/feature annotations: Ehrlichia tandem repeat (Ehrlichia_rpt), Ehrlichia tandem repeat (Ehrlichia_rpt), Ehrlichia tandem repeat (Ehrlichia_rpt), Ehrlichia tandem repeat (Ehrlichia_rpt), Ehrlichia tandem repeat (Ehrlichia_rpt)
Sequence:
MDIDNSNISTADIRSNTDGLIDIIMRILGFGNKNIVQPQDLGSEIYQQEQEDDTVSQPSLEPFVAESEVSKVEQEKTNPEVLIKDLQDVASHESGVSDQPAQVVTERENEIESHQGETEKESGITESHQKEDEIVSQSSSEPFVAESEVSKVEQEETNPEVLIKDLQDVASHESGVSDQPAQVVTERESEIESHQGETEKESGITESHQKEDEIVSQPSSEPFVAESEVSKVEQEETNPEVLIKDLQDVASHESGVSDQPAQVVTERESEIESHQGETEKESGITESHQKEDEIVSQPSSEPFVAESEVSKVEQEETNPEVLIKDLQDVASHESGVSDQPAQVVTERESEIESHQGETEKESGITESHQKEDEIVSQPSSEPFVAESEVSKVEQEKTNPEILVEDLPLGQVIPVVVEKDEMFAPSFNPIVIKEEDKVCETCEQEFEIVKDSQTVKGSEDIISPIECLESMDSIVSTIFESGMLCPMSKPGQYVCGYEMYMYGFQDVKDLLGGLLSNVPVCCNVSLYFMEHNYFTNHENINHNVVNDIV
Protein: High mobility group protein HMGI-C
UniProt accession: P52926
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HMGA2, HMGIC
Length: 109 residues
Disorder content (fraction disordered): 1
Dataset labels: Cancer-related proteins
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 109, 109, 109, 109
Curated region terms: disorder, disorder, nucleic acid binding, disorder
Domain/feature annotations: AT hook motif, AT hook motif, AT hook motif
Sequence:
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED
Protein: Crossover junction endonuclease EME1
UniProt accession: Q96AY2
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: EME1, MMS4
Length: 570 residues
Disorder content (fraction disordered): 0.05964912280701754
Curated region start positions: 445, 369, 369, 369, 369
Curated region end positions: 455, 402, 402, 402, 402
Curated region terms: disorder to order, disorder, DNA binding, flexible linker, molecular function regulator
Domain/feature annotations: Crossover junction endonuclease EME1, DNA-binding domain, ERCC4, Mus81-Eme1 complex, nuclease domain, subdomain 2, ERCC4, Mus81-Eme1 complex, nuclease domain, subdomain 2, ERCC4, Mus81-Eme1 complex, nuclease domain, subdomain 1, ERCC4 domain, EME1/MUS81, C-terminal
Cross-references: PDB:2ZIU, PDB:2ZIV, PDB:2ZIW, PDB:2ZIX
Sequence:
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALSLVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTEAQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTSTSRRIGPELSRRIYLQMTTLQPHLSLDSAD
Protein: Nuclear pore complex protein Nup50
UniProt accession: Q9JIH2
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Npap60, Nup50
Length: 466 residues
Disorder content (fraction disordered): 0.1351931330472103
Curated region start positions: 47
Curated region end positions: 109
Curated region terms: disorder
Domain/feature annotations: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), RanBP1 domain, NUP50 (Nucleoporin 50 kDa)
Cross-references: PDB:2C1M
Sequence:
MAKRVAEKELTDRNWDEEDEVEEMGTFSVASEEVMKNRAVKKAKRRNVGFESDSGGAFKGFKGLVVPSGGGGFSGFGGSGGKPLEGLTNGNSTDNATPFSNVKTAAEPKAAFGSFAVNGPTTLVDKKISSPKCNNSNQPPSSGPASSTACPGNAYHKQLAGLNCSVRDWIVKHVNTNPLCDLTPIFKDYERYLATIEKQLENGGGSSSESQTDRATAGMEPPSLFGSTKLQQESPFSFHGNKAEDTSEKVEFTAEKKSDAAQGATSASFSFGKKIESSALGSLSSGSLTGFSFSAGSSSLFGKDAAQSKAASSLFSAKASESPAGGGSSECRDGEEEENDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGVGTLHLKPTATQKTQLLVRADTNLGNILLNVLIAPNMPCTRTGKNNVLIVCVPNPPLDEKQPTLPATMLIRVKTSEDADELHKILLEKKDA
Protein: Nuclear receptor coactivator 2
UniProt accession: Q15596
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BHLHE75, NCOA2, SRC2, TIF2
Length: 1464 residues
Disorder content (fraction disordered): 0.1407103825136612
Dataset labels: Cancer-related proteins
Curated region start positions: 624, 624
Curated region end positions: 829, 829
Curated region terms: disorder, protein binding
Domain/feature annotations: Helix-loop-helix DNA-binding domain, PAS domain, PAS domain, PAS fold, Nuclear receptor coactivator, DUF1518, Nuclear receptor coactivator, Steroid receptor coactivator, PAS domain, Domain of unknown function (DUF4927), Unstructured region on nuclear receptor coactivator protein, Nuclear receptor coactivators bHLH domain
Sequence:
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC
Protein: mRNA interferase toxin RelE
UniProt accession: P0C077
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW1555, b1563, relE
Length: 95 residues
Disorder content (fraction disordered): 0.11578947368421053
Dataset labels: Unicellular toxins and antitoxins, RNA-binding proteins
Curated region start positions: 85, 81, 81
Curated region end positions: 95, 95, 95
Curated region terms: disorder, disorder to order, toxin sequestering activity
Domain/feature annotations: RelE-like, ParE toxin of type II toxin-antitoxin system, parDE
Cross-references: PDB:2KC8, PDB:2KC9, PDB:4FXE
Sequence:
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGKRERSEVYSEAVKRIL
Protein: Apolipoprotein C-II
UniProt accession: P02655
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: APC2, APOC2
Length: 101 residues
Disorder content (fraction disordered): 0.25742574257425743
Curated region start positions: 40, 40
Curated region end positions: 65, 65
Curated region terms: disorder, molecular function activator activity
Domain/feature annotations: Apolipoprotein C-II, Apolipoprotein C-II
Cross-references: PDB:1SOH
Sequence:
MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE
Protein: F-box only protein 4
UniProt accession: Q9UKT5
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: FBX4, FBXO4
Length: 387 residues
Disorder content (fraction disordered): 0.07751937984496124
Curated region start positions: 242
Curated region end positions: 271
Curated region terms: disorder
Domain/feature annotations: 1.20.1280.50, P-loop containing nucleotide triphosphate hydrolases, F-box-like
Cross-references: PDB:3L2O
Sequence:
MAGSEPRSGTNSPPPPFSDWGRLEAAILSGWKTFWQSVSKERVARTTSREEVDEAASTLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPISEVTDGAFFDYMAVYRMCCPYTRRASKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVNFQLNNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSRHNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSHIMAMTDPAFGSSGRPLLVLSCISQGDVKRMPCFYLAHELHLNLLNHPWLVQDTEAETLTGFLNGIEWILEEVESKRAR
Protein: Amyloid-beta A4 protein
UniProt accession: P08592
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: A4, AD1, App
Length: 770 residues
Disorder content (fraction disordered): 0.02077922077922078
Curated region start positions: 672, 672
Curated region end positions: 687, 687
Curated region terms: disorder, zinc ion binding
Domain/feature annotations: Amyloidogenic glycoprotein, heparin-binding domain, Amyloidogenic glycoprotein, amyloid-beta peptide, Amyloidogenic glycoprotein, copper-binding domain, Amyloid precursor protein, E2 domain, Pancreatic trypsin inhibitor Kunitz domain, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Kunitz/Bovine pancreatic trypsin inhibitor domain, Amyloid A4 N-terminal heparin-binding, Beta-amyloid peptide (beta-APP), Beta-amyloid precursor protein C-terminus, Copper-binding of amyloid precursor, CuBD, E2 domain of amyloid precursor protein
Sequence:
MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSIDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEAEDDEDVEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVSSQSLLKTTSEPLPQDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Protein: Pre-mRNA leakage protein 1
UniProt accession: Q07930
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: L1591, PML1, YLR016C
Length: 204 residues
Disorder content (fraction disordered): 0.3480392156862745
Curated region start positions: 1, 112, 22, 22, 1
Curated region end positions: 51, 121, 42, 42, 61
Curated region terms: disorder, disorder, disorder, protein binding, disorder
Domain/feature annotations: 2.60.200.20, FHA domain
Sequence:
MFHRRKRPYNTRNYGHDDKKFKSQYIDIMPDFSPSGLLELESNNKEGIALKHVEPQDAISPDNYMDMLGLEARDRTMYELVIYRKNDKDKGPWKRYDLNGRSCYLVGRELGHSLDTDLDDRTEIVVADIGIPEETSSKQHCVIQFRNVRGILKCYVMDLDSSNGTCLNNVVIPGARYIELRSGDVLTLSEFEEDNDYELIFMNV
Protein: Transcription elongation regulator 1
UniProt accession: O14776
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CA150, TAF2S, TCERG1
Length: 1098 residues
Disorder content (fraction disordered): 0.010018214936247724
Curated region start positions: 98, 98, 98
Curated region end positions: 108, 108, 108
Curated region terms: disorder, protein binding, disorder to order
Domain/feature annotations: FF domain, FF domain, FF domain, FF domain, FF domain, FF domain, 2.20.70.10, 2.20.70.10, 2.20.70.10, WW domain, WW domain, FF domain, FF domain, FF domain, FF domain, FF domain, FF domain, TCERG1 WW domain
Cross-references: PDB:3Q1I
Sequence:
MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK
Protein: Bromodomain-containing protein 4
UniProt accession: O60885
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BRD4, HUNK1
Length: 1362 residues
Disorder content (fraction disordered): 0.012481644640234948
Dataset labels: Cancer-related proteins, NDDs-related proteins, Condensates-related proteins
Curated region start positions: 333
Curated region end positions: 349
Curated region terms: disorder
Domain/feature annotations: Bromodomain-like, 1.20.1270.220, Bromodomain-like, Bromodomain, Bromodomain, Bromodomain extra-terminal - transcription regulation, C-terminal domain of bromodomain protein 4
Cross-references: PDB:2OUO
Sequence:
MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
Protein: Interferon regulatory factor 5
UniProt accession: Q13568
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: IRF5
Length: 498 residues
Disorder content (fraction disordered): 0.02008032128514056
Curated region start positions: 458
Curated region end positions: 467
Curated region terms: disorder
Domain/feature annotations: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, 2.60.200.10, Interferon regulatory factor transcription factor, Interferon-regulatory factor 3
Cross-references: PDB:3DSH
Sequence:
MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ
Protein: Bile acid receptor
UniProt accession: Q96RI1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Length: 486 residues
Disorder content (fraction disordered): 0.03292181069958848
Curated region start positions: 275
Curated region end positions: 290
Curated region terms: disorder
Domain/feature annotations: Retinoid X Receptor, Erythroid Transcription Factor GATA-1, subunit A, Ligand-binding domain of nuclear hormone receptor, Double treble clef zinc finger, C4 type
Cross-references: PDB:1OSH
Sequence:
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
Protein: Regulator of nonsense transcripts 1
UniProt accession: Q92900
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: KIAA0221, RENT1, UPF1
Length: 1129 residues
Disorder content (fraction disordered): 0.010628875110717449
Curated region start positions: 348, 348, 348, 348, 348
Curated region end positions: 359, 359, 359, 359, 359
Curated region terms: disorder, molecular function regulator, molecular function regulator, molecular function regulator, molecular function regulator
Domain/feature annotations: P-loop containing nucleotide triphosphate hydrolases, 2.40.30.230, Type III restriction enzyme, res subunit, RNA helicase (UPF2 interacting domain), AAA domain, AAA domain, RNA helicase UPF1, 1B domain
Cross-references: PDB:6EJ5
Sequence:
MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAGGPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPIHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVIIWLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRGTPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
Protein: Myocyte-specific enhancer factor 2A
UniProt accession: Q02078
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MEF2, MEF2A
Length: 507 residues
Disorder content (fraction disordered): 0.023668639053254437
Curated region start positions: 75
Curated region end positions: 86
Curated region terms: disorder
Domain/feature annotations: Transcription factor, MADS-box, SRF-type transcription factor (DNA-binding and dimerisation domain), Holliday junction regulator protein family C-terminal repeat
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNTQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNTEDRESPSVKRMRMDAWVT
Protein: Lysine--tRNA ligase
UniProt accession: C4M7X2
Organism: Entamoeba histolytica
Taxonomy: Eukaryota, Amoebozoa, Evosea, Archamoebae, Mastigamoebida, Entamoebidae, Entamoeba
Gene names: EHI_047810
Length: 769 residues
Disorder content (fraction disordered): 0.24317295188556567
Curated region start positions: 583
Curated region end positions: 769
Curated region terms: disorder
Domain/feature annotations: Nucleic acid-binding proteins, Nucleic acid-binding proteins, tRNA synthetases class II (D, K and N), tRNA synthetases class II (D, K and N), OB-fold nucleic acid binding domain, Putative tRNA binding domain
Cross-references: PDB:4UP7, PDB:4UP8, PDB:4UP9, PDB:4UPA
Sequence:
MSKQLFLNRCKDVEEYQKAGHNPWPHKFNVSITVPEFIAKYSGLEKSQVSDDIVSVAGRVLSKRSSSSALMFIDLHDSQTKLQIMLNKSAYENKEDFVSLTKMIYRGDICGFTGHPTRTKTGELSLIPISGMILSPCLHMLPSMHYGLGDQETRFRKRYLDLIVNPESVKNFVLRTKVVKAVRKYLDDKGFLEVETPILNTIPGGATARPFITHHNQLDIQMYMRIAPELYLKELVVGGINRVYEIGRLFRNEGIDQTHNPEFTTCEFYMAYADYNDIMKMTEELLGNMVKDITGGSTKLEIKDRLMDINNEEDIKMLEKFFKEPIPRPFNSAECSKVIEKHCTELNYYYDGNNEKAMKKLFADFVTEKKMVLDFTAPFKRISYVHALEEKFGEKIPRPLDGPEALTFLKKQAIRFNAICAEPQTTARVMDKLFGDLIEVDLVQPTFVCDQPQLMSPLAKYHRSEPELTERFELFILKREIANAYTELNNPIVQRSNFEQQAKDKAAGDDEAQLVDEVFLDAIEHAFPPTGGWGLGIDRLAMLLADVDNIKEVILFPTMRPEDELEKKAREAKEDAMVAQELAATEEKGGKKVVKPKANKQQPVKEVLDGFQLEIRVGKIVEAGPHPNSEHLLALKVDVGEEKPRSVVAGLAEHYKPEELLNQKATFVCNLKPSKLRGVASEAMILAATSLDGTKVKFCHPSADAAIGAQVIPKEGKVTISAKKISIDVVGKMNLALKGGLVRTNDVPLIVKDTELTVTVDEVVDGTVR