LiteFold/DisProt huggingface dataset:
Protein: Protein unc-13 homolog A
UniProt accession: Q62768
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Unc13a, Unc13h1
Length: 1735 residues
Disorder content (fraction disordered): 0.0207492795389049
Curated region start positions: 1341, 1458, 1517
Curated region end positions: 1351, 1467, 1531
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Phorbol esters/diacylglycerol binding domain (C1 domain), C2 domain, C2 domain, C2 domain, MUN domain
Cross-references: PDB:3SWH
Sequence:
MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQAIMADSEICGTKDPTFHRILLDAHFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDQQDKPLPVPSSQCCNWNYFGWGEQNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPRALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSELDDERDRDSYHSCHSSVSYHKDSPRWDQDEEDLEDLEDLEDEELPEEEELEEEELEEEEELEEEELELEEEEEVPDDLASYTQQEDTTVAEPKEFKRISFPTAAPQKEDKVSAVPIEAPDVSKGIPKAATPEEKAAAECAQEAEPPKSEESFRSREAEEGQEGQDAMSRAKANWLRAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEVFAVTKSAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVLDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYGREYQTDPAKKGEVPPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWSLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVAELPTFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIVSKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASGTLKELQVKLNNVLDELSHVFATSFQPHIEECVRQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMERTIVLPPLTDQTMIGTLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQVHGGKGTRFTLSEDVCPEMGSGVEDPVGEVSVHVELFTHPGTGEQKVTVKVVAANDLKWQTSGIFRPFIEVNIVGPQLSDKKRKFATKSKNNSWAPKYNESFQFSLSADAGPECYELQVCVKDYCFAREDRTVELAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP
Protein: Protein transport protein DSL1
UniProt accession: P53847
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: DSL1, N0842, YNL258C
Length: 754 residues
Disorder content (fraction disordered): 0.15384615384615383
Curated region start positions: 1, 388
Curated region end positions: 36, 467
Curated region terms: disorder, disorder
Domain/feature annotations: Retrograde transport protein Dsl1 N terminal, Retrograde transport protein Dsl1 C terminal
Cross-references: PDB:3ETU
Sequence:
MESLFPNKGEIIRELLKDPLILKNDSKRSNGSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMRNNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITENSIQFTPTVEWGKDKVHIEYDTFMDFVAQQYFPKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSSSHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPLKNLVSVINNKLTRLVAKSEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIRSIFEDPKKSWQNLEVVELTTSNTNTMSEKIGKNDSDVQNEKELHNAVSKDDDWNWEVEDDDADAWGDEIDVNIDDEEEKTNQEKEKEPEEEENAWDEAWAIDENIDDASLENGKEHLKAHDVGSLDKDHIEVTQLPKLFLAISQNFKSSFADSHVDEQYFAYKYNLLQTSYMAMCTANFSHNWCQLYVDMRYLIERDEKLYRIKELTRNLLETKLNMKYRIVCQLIRHQLTEFRENERNPSWDATIEKLLPYILKEIVRPLQKIRGEEGSRYLLSFLNFLYNDCVTKEILKWQIISEVNSENLGELVSLLVNNTDIQLLAKEPSYKKMREKFATMGKFLPLHLKEIMEMFYNGDFYLFATDELIQWIELLFADTPLRRNAIDDIYEIRGTALDD
Protein: Gamma-aminobutyric acid receptor subunit alpha-1
UniProt accession: P14867
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GABRA1
Length: 456 residues
Disorder content (fraction disordered): 0.13157894736842105
Dataset labels: NDDs-related proteins
Curated region start positions: 351
Curated region end positions: 410
Curated region terms: disorder
Domain/feature annotations: Neurotransmitter-gated ion-channel ligand binding domain, Neurotransmitter-gated ion-channel transmembrane region, Neurotransmitter-gated ion-channel transmembrane region
Cross-references: EMDB:EMD-4411, PDB:6I53
Sequence:
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
Protein: Gamma-aminobutyric acid receptor subunit beta-3
UniProt accession: P28472
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GABRB3
Length: 473 residues
Disorder content (fraction disordered): 0.2156448202959831
Dataset labels: NDDs-related proteins
Curated region start positions: 338
Curated region end positions: 439
Curated region terms: disorder
Domain/feature annotations: Neurotransmitter-gated ion-channel ligand binding domain, Neurotransmitter-gated ion-channel transmembrane region
Cross-references: EMDB:EMD-4411, PDB:6I53
Sequence:
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
Protein: Gamma-aminobutyric acid receptor subunit gamma-2
UniProt accession: P18507
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GABRG2
Length: 475 residues
Disorder content (fraction disordered): 0.3094736842105263
Dataset labels: NDDs-related proteins
Curated region start positions: 363, 1
Curated region end positions: 444, 65
Curated region terms: disorder, disorder
Domain/feature annotations: Neurotransmitter-gated ion-channel ligand binding domain, Neurotransmitter-gated ion-channel transmembrane region
Cross-references: EMDB:EMD-4411, PDB:6I53
Sequence:
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Protein: Exocyst complex component EXO70
UniProt accession: P19658
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: EXO70, J0932, YJL085W
Length: 623 residues
Disorder content (fraction disordered): 0.019261637239165328
Curated region start positions: 222
Curated region end positions: 233
Curated region terms: disorder
Domain/feature annotations: Exo70 exocyst complex subunit C-terminal, Exocyst complex component Exo70 N-terminal
Cross-references: PDB:2B1E
Sequence:
MPAEIDIDEADVLVLSQELQKTSKLTFEINKSLKKIAATSNQSSQLFTPILARNNVLTTLQRNIESTLNSVASVKDLANEASKYEIILQKGINQVGLKQYTQVVHKLDDMLEDIQSGQANREENSEFHGILTHLEQLIKRSEAQLRVYFISILNSIKPFDPQINITKKMPFPYYEDQQLGALSWILDYFHGNSEGSIIQDILVGERSKLILKCMAFLEPFAKEISTAKNAPYEKGSSGMNSYTEALLGFIANEKSLVDDLYSQYTESKPHVLSQILSPLISAYAKLFGANLKIVRSNLENFGFFSFELVESINDVKKSLRGKELQNYNLLQDCTQEVRQVTQSLFRDAIDRIIKKANSISTIPSNNGVTEATVDTMSRLRKFSEYKNGCLGAMDNITRENWLPSNYKEKEYTLQNEALNWEDHNVLLSCFISDCIDTLAVNLERKAQIALMPNQEPDVANPNSSKNKHKQRIGFFILMNLTLVEQIVEKSELNLMLAGEGHSRLERLKKRYISYMVSDWRDLTANLMDSVFIDSSGKKSKDKEQIKEKFRKFNEGFEDLVSKTKQYKLSDPSLKVTLKSEIISLVMPMYERFYSRYKDSFKNPRKHIKYTPDELTTVLNQLVR
Protein: pH-response transcription factor pacC/RIM101
UniProt accession: F2SDI0
Organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Pezizomycotina, Eurotiomycetes, Eurotiomycetidae, Onygenales, Arthrodermataceae, Trichophyton
Gene names: TERG_00838
Length: 815 residues
Disorder content (fraction disordered): 0.28343558282208586
Curated region start positions: 585, 585, 585, 585
Curated region end positions: 815, 815, 815, 815
Curated region terms: disorder, disorder, disorder, disorder
Sequence:
MSSTQDQDHSALAQHQQQHPPSQHQQQSQQQQHQHQQAAAGSQSEQTQAQAQQPRSQMQSAPSLQQQPPQQQQPQQQGQQGQQGQQQQPTSQTVQSVPVQASLQHAAAAAAAVAPPGVQQVAPSSPNAPGSLECQWQGCQELCPTPEALYEHVCERHVGRKSTNNLNLTCGWSNCRTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSVLMRSPEPGAGQRQQPPTGMFGVGLGPDGKPAHFFEGSLGPVPQAYGHPPPQYYQPQPPQQQPNPSYGNVYYAVGHDAAHQASYESKKRGYDALNEFFGDLKRRQFDPTSYAAVGQRLLNLHGLPLPLTHAGAVPEYQPMPAMVSVGGGHSGYQSAGPIPTQSYHLPPMGNLRTKADLMNIDQFLEQMQSTVYESDENVAAAGVAQPGAHYVQGPLSYRTTNSPPTHHQSHHHHPHATATTATTTTAATTASMISTPAAATPASSVSAASRSPHASTPALTPPSSAQSYTSGRSPISLASSHGMSPSHHPSTAGMYPTLPATTGQDSLSSSGYPTTVSSAAPPSTLSSIFDDDRRRYTGGMLQRSRPDIDLSTPSIKRDADAAAAAAAKDEPKLSSSVIDPALSRASADMDEDAAPRRSPSSTPTPTATTAAAAGPDDRQPVGEQQWVENVRLLQRLRDYVLERLNNGDYVDEDKQEDSDKEEDAKTDKASPGSASASDAATRAGEYPSIKMHGMEAIAAAAVAHEEGRDSQMPRDDEDQESPSTPTARSTTTMLDAEEEAKQAGENLYPVLKMAVDDDGADTDGDEKMGQ
Protein: Isoform 3 of Protein CLEC16A
UniProt accession: Q80U30-3
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Clec16a, Kiaa0350
Length: 912 residues
Disorder content (fraction disordered): 0.13815789473684212
Curated region start positions: 347, 347, 347, 347, 347, 347, 347
Curated region end positions: 472, 472, 472, 472, 472, 472, 472
Curated region terms: disorder, disorder, disorder, disorder, protein binding, regulation of proteasomal ubiquitin-dependent protein catabolic process, protein destabilization
Sequence:
MFGRSRSWVGGGHSKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENPDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYTKPAQDVPRSSAKPSIRCFIKPTETLERSLEMNKHKGKKRMQKRPNYKNVGEEEDEERGSAEDAQEDAEKTKGTEGGSKSMKTSGEREEIEMVIMKLGKLSEVAAAGTSVQEQNTTDEEKSAATNSENAQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLKRIQLPVPSEAEKTTYNHLLAERLIRIMNNAAQPDGRIRLATLELSCLLLKQQVLTSSGCVIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTIKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFVFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLCSSSSSSQHLPFRFYEQCRRGSSDPTVQRSVFASVDKVPGKPHLLLGTQAAFLLSPLEAFLSESRLLAALAS
Protein: 25 kDa protein dehydrin
UniProt accession: Q7Y1A0
Organism: Solanum sogarandinum
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, asterids, lamiids, Solanales, Solanaceae, Solanoideae, Solaneae, Solanum
Length: 210 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1
Curated region end positions: 210, 210, 210, 210
Curated region terms: disorder, disorder to order, phospholipid binding, phospholipid binding
Domain/feature annotations: Dehydrin
Sequence:
MADQYEQNKPSVEETVGANVEATDRGLFDFIGKKEEEKPSHAHEEEAISSEFCEKVKVSEEEEHKEKEKKEEKKLHRSSSSSSSSSDEEEEIGEDGQIIKKKKKKGLKEKIKEKISGDHKEEVKTEDTSVPVEKYEETEEKKGFLEKIKEKLPGGGHKKTEEVAAPPPPPPAAVDHEAEGKEKKGFLDKIKEKLPGYHSKTEEEKEKEKD
Protein: Silver-binding protein SilE
UniProt accession: Q9Z4N3
Organism: Salmonella typhimurium
Taxonomy: Bacteria, Pseudomonadota, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Salmonella
Gene names: silE
Length: 143 residues
Disorder content (fraction disordered): 0.8601398601398601
Curated region start positions: 21, 21, 110, 110, 128, 57, 21, 80, 59, 129
Curated region end positions: 143, 143, 122, 123, 142, 95, 143, 90, 72, 141
Curated region terms: disorder, disorder to order, metal ion binding, disorder to order, disorder to order, disorder to order, disorder to order, metal ion binding, metal ion binding, metal ion binding
Sequence:
MKNIVLASLLGFGLISSAWATETVNIHERVNNAQAPAHQMQSAAAPVGIQGTAPRMAGMDQHEQAIIAHETMTNGSADAHQKMVESHQRMMGSQTVSPTGPSKSLAAMNEHERAAVAHEFMNNGQSGPHQAMAEAHRRMLSAG
Protein: Kinesin-like protein KIF2C
UniProt accession: Q922S8
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Kif2c
Length: 721 residues
Disorder content (fraction disordered): 0.056865464632454926
Curated region start positions: 183
Curated region end positions: 223
Curated region terms: disorder
Domain/feature annotations: Kinesin motor domain, Kinesin-like protein KIF2A-like, N-terminal
Cross-references: PDB:1V8J
Sequence:
MESLHARLFPGLSINIQRSNGLIHPANISTVNVEKSCVSVEWIEGGTTKGKEIDIDDVAAINPELLQLLPLRPKDSLPLQENVTVPKQKRKSVNSKIPALKEGLRSRSTRMSTVSEVRIPAQENEMEVELPVPTNSRKQFAIPSHPRASCSTVTELPLLMVSEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKMKNKREEKRAQNSELRIKRAQEYDSSFPNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGQTFANSNSSRSHACFQILLRTKGRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQPVQMETEVMEASSNGTSLTGNEEEELSSQMSSFNEAMTQIRELEERALEELREIIQQGPNWLELSEMTDQPDYDLETFVNKAESALTQQAKQAKHFSALREVIKALRLAMQLEEQASKQINSKKRHQ
Protein: Active regulator of SIRT1
UniProt accession: Q86WX3
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: AROS, RPS19BP1
Length: 136 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 62, 1, 1
Curated region end positions: 136, 136, 136, 71, 136, 136
Curated region terms: disorder, disorder, negative regulation of deacetylase activity, protein binding, protein binding, protein binding
Domain/feature annotations: Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
Sequence:
MSAALLRRGLELLAASEAPRDPPGQAKPRGAPVKRPRKTKAIQAQKLRNSAKGKVPKSALDEYRKRECRDHLRVNLKFLTRTRSTVAESVSQQILRQNRGRKACDRPVAKTKKKKAEGTVFTEEDFQKFQQEYFGS
Protein: Outer membrane lipoprotein omp19
UniProt accession: Q2YLR6
Organism: Brucella abortus (strain 2308)
Taxonomy: Bacteria, Pseudomonadota, Alphaproteobacteria, Hyphomicrobiales, Brucellaceae, Brucella/Ochrobactrum group, Brucella
Gene names: BAB1_1930, omp19
Length: 177 residues
Disorder content (fraction disordered): 0.3615819209039548
Curated region start positions: 22, 22, 22, 22, 22, 22
Curated region end positions: 85, 61, 81, 81, 81, 81
Curated region terms: disorder, negative regulation of peptidase activity, disorder, positive regulation of immune response, disorder, disorder
Domain/feature annotations: Protease inhibitor Inh
Sequence:
MGISKASLLSLAAAGIVLAGCQSSRLGNLDNVSPPPPPAPVNAVPAGTVQKGNLDSPTQFPNAPSTDMSAQSGTQVASLPPASAPDLTPGAVAGVWNASLGGQSCKIATPQTKYGQGYRAGPLRCPGELANLASWAVNGKQLVLYDANGGTVASLYSSGQGRFDGQTTGGQAVTLSR
Protein: Protein NDRG1
UniProt accession: Q92597
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CAP43, DRG1, NDRG1, RTP
Length: 394 residues
Disorder content (fraction disordered): 0.21065989847715735
Dataset labels: Cancer-related proteins, Age-related disorders proteins
Curated region start positions: 312, 312, 338, 312
Curated region end positions: 394, 394, 394, 394
Curated region terms: disorder, disorder, nickel cation binding, nickel cation binding
Domain/feature annotations: Ndr family
Sequence:
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSAGPKSMEVSC
Protein: GTP cyclohydrolase-2
UniProt accession: P0A7I7
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Pseudomonadota, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW1269, b1277, ribA
Length: 196 residues
Disorder content (fraction disordered): 0.11224489795918367
Curated region start positions: 175
Curated region end positions: 196
Curated region terms: disorder
Domain/feature annotations: GTP cyclohydrolase II
Cross-references: PDB:2BZ0, PDB:2BZ1
Sequence:
MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK
Protein: Defective in cullin neddylation protein 1
UniProt accession: Q12395
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: DCN1, L3111, YLR128W
Length: 269 residues
Disorder content (fraction disordered): 0.07806691449814127
Curated region start positions: 1, 56
Curated region end positions: 11, 65
Curated region terms: disorder, disorder
Domain/feature annotations: Cullin binding, UBA-like domain
Cross-references: PDB:3BQ3
Sequence:
MSNNKIKRKDASPEQEAIESFTSLTKCDPKVSRKYLQRNHWNINYALNDYYDKEIGTFTDEVSTVAHPPVYPKELTQVFEHYINNNLFDIDSLVKFIEELGYNLEDLATLCLAHLLGYKKLEEPLKREDFLSTWFMQGCSTISDMQECIKTLDVKLHEDLQYFTQIYNYAFNLILDPNRKDIDTDEGIQYWKLFFQPEYPVRMEPDLLEAWFRFLRDEGKTTISKDTWRMLLLFFKRYPTIQKIISDYDETAAWPFIIDEFYECLQDQQ
Protein: GTPase ObgE/CgtA
UniProt accession: P42641
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Pseudomonadota, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW3150, b3183, cgtA, obg, obgE, yhbZ
Length: 390 residues
Disorder content (fraction disordered): 0.1358974358974359
Dataset labels: RNA-binding proteins
Curated region start positions: 361, 361, 338
Curated region end positions: 382, 382, 390
Curated region terms: disorder to order, disorder, disorder
Domain/feature annotations: GTP1/OBG, 50S ribosome-binding GTPase
Cross-references: PDB:4CSU, PDB:8BFT
Sequence:
MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGTDPVENARIIISELEKYSQDLATKPRWLVFNKIDLLDKVEAEEKAKAIAEALGWEDKYYLISAASGLGVKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQLEEIAEEDDEDWDDDWDEDDEEGVEFIYKR
Protein: DBF2 kinase activator protein MOB1
UniProt accession: P40484
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: MOB1, YIL106W
Length: 314 residues
Disorder content (fraction disordered): 0.07643312101910828
Curated region start positions: 114, 86, 114, 86
Curated region end positions: 125, 97, 125, 97
Curated region terms: disorder, disorder, flexible linker, flexible linker
Domain/feature annotations: Mob1/phocein family
Cross-references: PDB:2HJN
Sequence:
MSFLQNFHISPGQTIRSTRGFKWNTANAANNAGSVSPTKATPHNNTINGNNNNANTINNRADFTNNPVNGYNESDHGRMSPVLTTPKRHAPPPEQLQNVTDFNYTPSHQKPFLQPQAGTTVTTHQDIKQIVEMTLGSEGVLNQAVKLPRGEDENEWLAVHCVDFYNQINMLYGSITEFCSPQTCPRMIATNEYEYLWAFQKGQPPVSVSAPKYVECLMRWCQDQFDDESLFPSKVTGTFPEGFIQRVIQPILRRLFRVYAHIYCHHFNEILELNLQTVLNTSFRHFCLFAQEFELLRPADFGPLLELVMELRDR
Protein: Apical membrane antigen 1
UniProt accession: C0IR59
Organism: Babesia divergens
Taxonomy: Eukaryota, Sar, Alveolata, Apicomplexa, Aconoidasida, Piroplasmida, Babesiidae, Babesia
Length: 606 residues
Disorder content (fraction disordered): 0.12211221122112212
Curated region start positions: 173, 258, 353
Curated region end positions: 193, 271, 391
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Apical membrane antigen 1
Cross-references: PDB:4APM
Sequence:
MEATTTAKTGIWKKYLTLVVPILCVVILSGEVVPTEAAFHIRENEPKRRTSRRDGGRSSRRQTTNSRLSADDDDSDDGDDSDRPRGRQQSSKSTPKDIWGRYMAKFDLAKSHGSGIYVDLGGTERVGATQHRMPTGKCPVMGKVINLGNNADFLNRISAENPQDRGLAFPDTAVAVTRNSNARNRAAAEKTEIILSPVSAADLVRWGYDGNDVANCAEYAGNIIPASDTATKYRYPCVYDAKEEMCHILFTPMQYNRGSRYCDNDGSQDEGTSSLLCMEPMKSGIDAHLYYGSSRVDKKWEENCPMYPVKDAIFGRGANGSCVAIESAFEEFTRDAEECSALMFENAAADLEIDEEADNFDELKTLSDGLRNIKASKIAQALFSPIAKAGTSAKNSKGVGMNWANYDSNTGLCRVIEETPNCLIIDAGSFAMTAVGSPLEQDAVPFPCDIVTNGYIEPRPRSRHRNTTPIFEVTTALSREALKCSKYVHEKYSESCGTYYYCSEEKPSSWAFWRNLDWKRVAKYVMSLIAIAILYMAIHWTYKRLWTTKAKPESDEYERFMSKYDYDEGIHTKGHMDQQLRSDAYVWGEAAARPSDVTPVHLSKVQ
Protein: NB-ARC domain-containing protein
UniProt accession: A0A3Q7EK40
Organism: Solanum lycopersicum
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, asterids, lamiids, Solanales, Solanaceae, Solanoideae, Solaneae, Solanum, Solanum subgen. Lycopersicon
Length: 932 residues
Disorder content (fraction disordered): 0.05472103004291846
Curated region start positions: 275, 374, 416
Curated region end positions: 287, 391, 435
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: NB-ARC domain, Rx N-terminal domain, Disease resistance protein Winged helix domain, Leucine-rich repeat region
Cross-references: PDB:6S2P
Sequence:
MIIYPSQLSKMQTNCLHNTHFSSSSEHNSLLLQEINRKKKKENNMVDVGVEFLLENLKQLVLDNVELIGGAKDEIENLRDDLSEFNAFLKQAAMVRSENPVLKELVRSIRKVVNRAEDAVDKFVIEAKVHKDKGFKGVFDKPGHYRRVRDAAVEIKGIRDKMREIRQNKAHGLQALLQDHDDSISRGGEERQPPVVEEDDVVGFDDEAQTVIDRLLEGSGDLEVIPVVGMPGLGKTTLATKIFKHPKIEYEFFTRLWLYVSQSYKTRELYLNIISKFTGNTKHCRDMSEKDLALKVQEILEEGGKYLIVLDDVWSTDAWDRIKIAFPKNDKGNRVLLTTRDHRVARYCNRSPHDLKFLTDEESWILLEKRAFHKAKCLPELETNGKSIARKCKGLPLAIVVIAGALIGKSKTIKEWEQVDQSVGEHFINRDQPNSCDKLVRMSYDVLPYDWKACFLYFGTFPRGYLIPARKLIRLWIAEGFIQYRGDLSPECKAEEYLNELVNRNLVMVMQRTVDGQIKTCRVHDMLYEFCWQEATTEENLFHEVKFGGEQSVREVSTHRRLCIHSSVVEFISKKPSGEHVRSFLCFSPEKIDTPPTVSANISKAFPLLRVFDTESIKINRFCKEFFQLYHLRYIAFSFDSIKVIPKHVGELWNVQTLIVNTQQINLDIQADILNMPRLRHLLTNTSAKLPALANPKTSKTTLVNQSLQTLSTIAPESCTEYVLSRAPNLKKLGIRGKIAKLMEPSQSVLLNNVKRLQFLENLKLINVGQIDQTQLRLPPASIFPTKLRKLTLLDTWLEWDDMSVLKQLENLQVLKLKDNAFKGENWELNDGGFPFLQVLCIERANLVSWNASGDHFPRLKHLHISCDKLEKIPIGLADICSLQVMDLRNSTKSAAKSAREIQAKKNKLQPAKSQKFELSVFPPDSDVQTAS