LiteFold/DisProt huggingface dataset:
Protein: Proline-rich nuclear receptor coactivator 2
UniProt accession: Q9NPJ4
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HSPC208, PNRC2
Length: 139 residues
Disorder content (fraction disordered): 0.7266187050359713
Dataset labels: RNA-binding proteins
Curated region start positions: 1
Curated region end positions: 101
Curated region terms: disorder
Domain/feature annotations: Proline-rich nuclear receptor coactivator motif
Cross-references: PDB:4B6H
Sequence:
MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV
Protein: Receptor-interacting serine/threonine-protein kinase 1
UniProt accession: Q13546
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: RIP, RIP1, RIPK1
Length: 671 residues
Disorder content (fraction disordered): 0.4232488822652757
Dataset labels: Condensates-related proteins
Curated region start positions: 300, 496, 549, 496, 525, 532, 532, 532, 496, 496, 496, 496, 496, 539, 539, 539
Curated region end positions: 560, 531, 583, 583, 555, 548, 549, 549, 583, 583, 583, 583, 583, 545, 545, 545
Curated region terms: disorder, disorder, disorder, amyloid fibril formation, protein serine/threonine kinase binding, protein serine/threonine kinase binding, order, disorder to order, amyloid fibril formation, identical protein binding, identical protein binding, amyloid fibril formation, amyloid fibril formation, necroptotic process, activation of protein kinase activity, ripoptosome assembly involved in necroptotic process
Domain/feature annotations: Death domain, Protein tyrosine and serine/threonine kinase
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
Protein: Receptor-interacting serine/threonine-protein kinase 2
UniProt accession: O43353
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Length: 540 residues
Disorder content (fraction disordered): 0.07407407407407407
Curated region start positions: 173, 519, 512
Curated region end positions: 183, 540, 540
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Caspase recruitment domain, Protein tyrosine and serine/threonine kinase
Cross-references: BMRB:27555, EMDB:4399, PDB:5NG0, PDB:6GGS
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Protein: Origin recognition complex subunit 2
UniProt accession: Q75PQ8
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Orc2, Orc2l
Length: 576 residues
Disorder content (fraction disordered): 0.1423611111111111
Curated region start positions: 1, 29
Curated region end positions: 10, 100
Curated region terms: disorder, disorder
Domain/feature annotations: Origin recognition complex subunit 2 RecA-like domain, ORC2 WHD
Cross-references: PDB:8SIU
Sequence:
MSTLRLKEAKVPSVQFVGDDDVLSHILDREGGTKLKKEKVQLLVNPQKVIKKAECELEKSDLEVLEDQNYVEVLGRNIQESLGNGSAVDGRNKVYSFQHRKHPEEMTKLALELAKTSGKIDPLASNDPKITKNIARKSKGHSSEKAPLENNNKNEFPSIQPHNVRKRLIASRSHCDSESEYSASSSEDDEEVAKDDEEDTNVVRCSKKSQGQNRLLPAPVSKEILPKKRKRDKAGDLVEEYFEAHSSSKVLTSDRTLQKLRRARVDQKTLRNLLSKFVPSFSTEIGQLNQQHERLFDKWILQLRLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGFFPGISVKSILNSITEDVLSHMGTFQSVLDQRDWIMNRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLRNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKYQLDNQDCPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGTLADFLEKEEEEES
Protein: Histone H2A type 1
UniProt accession: P06897
Organism: Xenopus laevis
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Amphibia, Batrachia, Anura, Pipoidea, Pipidae, Xenopodinae, Xenopus, Xenopus
Length: 130 residues
Disorder content (fraction disordered): 0.08461538461538462
Curated region start positions: 120
Curated region end positions: 130
Curated region terms: disorder
Domain/feature annotations: Core histone H2A/H2B/H3/H4 domain, C-terminus of histone H2A
Cross-references: PDB:8SIY
Sequence:
MSGRGKQGGKTRAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQSVLLPKKTESAKSAKSK
Protein: Subtilisin-like protease 1
UniProt accession: Q8I0V0
Organism: Plasmodium falciparum (isolate 3D7)
Taxonomy: Eukaryota, Sar, Alveolata, Apicomplexa, Aconoidasida, Haemosporida, Plasmodiidae, Plasmodium, Plasmodium (Laverania)
Gene names: PF3D7_0507500, SUB1
Length: 688 residues
Disorder content (fraction disordered): 0
Curated region start positions: 218, 218
Curated region end positions: 222, 329
Curated region terms: self proteolysis, flexible N-terminal tail
Domain/feature annotations: Subtilase family, SUB1 protease Prodomain ProdP9
Cross-references: PDB:8POL
Sequence:
MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH
Protein: Arginase
UniProt accession: Q8I384
Organism: Plasmodium falciparum (isolate 3D7)
Taxonomy: Eukaryota, Sar, Alveolata, Apicomplexa, Aconoidasida, Haemosporida, Plasmodiidae, Plasmodium, Plasmodium (Laverania)
Gene names: ARG, PF3D7_0906500
Length: 411 residues
Disorder content (fraction disordered): 0.19951338199513385
Curated region start positions: 72
Curated region end positions: 153
Curated region terms: disorder
Domain/feature annotations: Arginase family
Cross-references: PDB:3MMR
Sequence:
MLDTIESYIKSHKEKENLYVKKNVSIIGSPLAAGQPLGGVQLACDDLRKLGLHNVIDVLGWKYEDIGNIDNGDNEMKQEKKTNNYINNNDNNNDNNNDNNNDNNNNCYIPNGVIKEKKHDLSNNKMNGYVNHNFYGNYEENNVISTNDKYKNNCYYDNIRNIKEIGIFSKNLFDTMSNELRKKNFVLNIGGDHGVAFSSILSSLQMYQNLRVIWIDAHGDINIPETSPSGNYHGMTLAHTLGLFKKKVPYFEWSENLTYLKPENTAIIGIRDIDAYEKIILKKCNINYYTIFDIEKNGIYNTICTALEKIDPNSNCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILAETKRVVSMDLVEYNPSLDEVDKKVHGDSLPILDNATKTGKLCLELIARVLGYDIV
Protein: 60S ribosomal subunit assembly/export protein LOC1
UniProt accession: P43586
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: LOC1, YFR001W
Length: 204 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 39, 63, 89, 137, 154, 170, 191, 1, 1, 1, 1, 1, 1
Curated region end positions: 204, 14, 47, 69, 95, 147, 165, 178, 199, 204, 204, 204, 204, 204, 20
Curated region terms: disorder, RNA binding, RNA binding, RNA binding, RNA binding, RNA binding, RNA binding, RNA binding, RNA binding, rRNA binding, RNA folding chaperone, RNA strand annealing activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity
Sequence:
MAPKKPSKRQNLRREVAPEVFQDSQARNQLANVPHLTEKSAQRKPSKTKVKKEQSLARLYGAKKDKKGKYSEKDLNIPTLNRAIVPGVKIRRGKKGKKFIADNDTLTLNRLITTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEALKQDKLEEKKDEIKKKSSVARTIRRKNKRDMLKSEAKASESKTEGRKVKKVSFAQ
Protein: Heat shock protein beta-8
UniProt accession: Q9UJY1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CRYAC, E2IG1, HSP22, HSPB8, PP1629
Length: 196 residues
Disorder content (fraction disordered): 0.5867346938775511
Dataset labels: Autophagy-related proteins, Age-related disorders proteins
Curated region start positions: 1, 171
Curated region end positions: 89, 196
Curated region terms: disorder, disorder
Domain/feature annotations: Hsp20/alpha crystallin family
Sequence:
MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT
Protein: Endonuclease 8-like 2
UniProt accession: Q969S2
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NEIL2
Length: 332 residues
Disorder content (fraction disordered): 0.22289156626506024
Curated region start positions: 56
Curated region end positions: 129
Curated region terms: disorder
Domain/feature annotations: Formamidopyrimidine-DNA glycosylase H2TH domain
Sequence:
MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHFGGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREVLVDHVVEFSTAWLQGKFQGRPQHTQVYQKEQCPAGHQVMKEAFGPEDGLQRLTWWCPQCQPQLSEEPEQCQFS
Protein: Bouquet formation protein 4
UniProt accession: O60158
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Taphrinomycotina, Schizosaccharomycetes, Schizosaccharomycetales, Schizosaccharomycetaceae, Schizosaccharomyces
Gene names: SPBC19C7.10, bqt4
Length: 432 residues
Disorder content (fraction disordered): 0.11574074074074074
Curated region start positions: 364, 364, 364, 372, 364, 364, 364, 364, 364, 364, 364, 364
Curated region end positions: 413, 413, 413, 377, 413, 413, 413, 383, 413, 413, 413, 413
Curated region terms: nuclear membrane biogenesis, chromosome organization, lipid binding, lipid binding, molecular condensate scaffold activity, molecular condensate scaffold activity, disorder, nuclear membrane organization, nuclear envelope, nuclear envelope organization, centromere clustering at the mitotic interphase nuclear envelope, regulation of membrane lipid distribution
Sequence:
MTENEKSRSLPAERNPLYKDDTLDHTPLIPKCRAQVIEFPDGPATFVRLKCTNPESKVPHFLMRMAKDSSISATSMFRSAFPKATQEEEDLEMRWIRDNLNPIEDKRVAGLWVPPADALALAKDYSMTPFINALLEASSTPSTYATPSRPTAQKSETSEGEPESSTSATTTSVARRTRQRLAEHLENSKKTILQHDNKEEDKEIHSEENETKDEIKSEKKEPEIKKQEGGSSTEKVGQPSSSDDKAKGSTSKDQPSEEEEKTSDIQDRKIKTPIKPSLLGKIRSSVNKGMTDVASQVNRGMTDVASQVNKGVNGVASQVNKGMNGVANQVNKGVTGVASQVRKPVGKLEKKFENLEKSIGDTLKSSIRSSPKSKKRSREDFEENEDYNAMVPVKRSRITKLESEVYYEKRKVRALGGIAIGLGVGAILPFLF
Protein: Transcription factor PU.1
UniProt accession: P17433
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Sfpi-1, Sfpi1, Spi1
Length: 272 residues
Disorder content (fraction disordered): 0.6727941176470589
Curated region start positions: 1, 260
Curated region end positions: 170, 272
Curated region terms: disorder, disorder
Domain/feature annotations: Ets-domain
Cross-references: EMDB:28629, PDB:8EVH
Sequence:
MLQACKMEGFSLTAPPSDDLVTYDSELYQRPMHDYYSFVGSDGESHSDHYWDFSAHHVHNNEFENFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHTGLSHQVSYMPRMCFPYQTLSPAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH
Protein: Neurofilament light polypeptide
UniProt accession: P08551
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Nefl, Nf68, Nfl
Length: 543 residues
Disorder content (fraction disordered): 0.26887661141804786
Curated region start positions: 440, 399, 399, 398, 399, 398
Curated region end positions: 543, 439, 439, 543, 439, 543
Curated region terms: disorder, identical protein binding, molecular condensate scaffold activity, disorder, intermediate filament polymerization, disorder
Domain/feature annotations: Intermediate filament protein, Intermediate filament head (DNA binding) region
Sequence:
MSSFGYDPYFSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQAQIQYAQISVEMDVSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRSTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYSGLQSSSYLMSARSFPAYYTSHVQEEQTEVEETIEATKAEEAKDEPPSEGEAEEEEKEKEEGEEEEGAEEEEAAKDESEDTKEEEEGGEGEEEDTKESEEEEKKEESAGEEQVAKKKD
Protein: Damage suppressor protein
UniProt accession: P0DOW4
Organism: Ramazzottius varieornatus
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Tardigrada, Eutardigrada, Parachela, Hypsibioidea, Ramazzottiidae, Ramazzottius
Gene names: Dsup, RvY_17224
Length: 445 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1
Curated region end positions: 445, 445, 445
Curated region terms: disorder, disorder, DNA binding
Sequence:
MASTHQSSTEPSSTGKSEETKKDASQGSGQDSKNVTVTKGTGSSATSAAIVKTGGSQGKDSSTTAGSSSTQGQKFSTTPTDPKTFSSDQKEKSKSPAKEVPSGGDSKSQGDTKSQSDAKSSGQSQGQSKDSGKSSSDSSKSHSVIGAVKDVVAGAKDVAGKAVEDAPSIMHTAVDAVKNAATTVKDVASSAASTVAEKVVDAYHSVVGDKTDDKKEGEHSGDKKDDSKAGSGSGQGGDNKKSEGETSGQAESSSGNEGAAPAKGRGRGRPPAAAKGVAKGAAKGAAASKGAKSGAESSKGGEQSSGDIEMADASSKGGSDQRDSAATVGEGGASGSEGGAKKGRGRGAGKKADAGDTSAEPPRRSSRLTSSGTGAGSAPAAAKGGAKRAASSSSTPSNAKKQATGGAGKAAATKATAAKSAASKAPQNGAGAKKKGGKAGGRKRK
Protein: YopH targeting protein
UniProt accession: Q7BTX0
Organism: Yersinia pestis
Taxonomy: Bacteria, Pseudomonadota, Gammaproteobacteria, Enterobacterales, Yersiniaceae, Yersinia
Gene names: Y0082, YPCD1.95c, sycH
Length: 141 residues
Disorder content (fraction disordered): 0.14893617021276595
Curated region start positions: 121, 121
Curated region end positions: 141, 141
Curated region terms: disorder, flexible C-terminal tail
Domain/feature annotations: Tir chaperone protein (CesT) family
Cross-references: PDB:1TTW
Sequence:
MRTYSSLLEEFATELGLEEIETNELGHGAVTIDKIWVVHLAPINEKELVAFMRAGILTGQSQLYDILRKNLFSPLSGVIRCALDKDDHWLLWSQLNINDTSGTQLASVLTSLVDKAVTLSCEPTMKKEEDDHRPSSSHLLV
Protein: Homeobox protein MSX-1
UniProt accession: P28360
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: HOX7, MSX1
Length: 303 residues
Disorder content (fraction disordered): 0.5676567656765676
Curated region start positions: 1
Curated region end positions: 172
Curated region terms: disorder
Domain/feature annotations: Homeodomain
Sequence:
MAPAADMTSLPLGVKVEDSAFGKPAGGGAGQAPSAAAATAAAMGADEEGAKPKVSPSLLPFSVEALMADHRKPGAKESALAPSEGVQAAGGSAQPLGVPPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKPERTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT
Protein: N-acetylmuramoyl-L-alanine amidase
UniProt accession: Q96PD5
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PGLYRP2, PGLYRPL, PGRPL, UNQ3103/PRO10102
Length: 576 residues
Disorder content (fraction disordered): 0.078125
Curated region start positions: 164, 164
Curated region end positions: 208, 208
Curated region terms: molecular condensate scaffold activity, disorder
Domain/feature annotations: N-acetylmuramoyl-L-alanine amidase
Sequence:
MAQGVLWILLGLLLWSDPGTASLPLLMDSVIQALAELEQKVPAAKTRHTASAWLMSAPNSGPHNRLYHFLLGAWSLNATELDPCPLSPELLGLTKEVARHDVREGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGRRVINLPLDSMAAPWETGDTFPDVVAIAPDVRATSSPGLRDGSPDVTTADIGANTPDATKGCPDVQASLPDAKAKSPPTMVDSLLAVTLAGNLGLTFLRGSQTQSHPDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGALDGVILGDYLSRTPEPRPSLSHLLSQYYGAGVARDPGFRSNFRRQNGAALTSASILAQQVWGTLVLLQRLEPVHLQLQCMSQEQLAQVAANATKEFTEAFLGCPAIHPRCRWGAAPYRGRPKLLQLPLGFLYVHHTYVPAPPCTDFTRCAANMRSMQRYHQDTQGWGDIGYSFVVGSDGYVYEGRGWHWVGAHTLGHNSRGFGVAIVGNYTAALPTEAALRTVRDTLPSCAVRAGLLRPDYALLGHRQLVRTDCPGDALFDLLRTWPHFTATVKPRPARSVSKRSRREPPPRTLPATDLQ
Protein: Protein shisa-5
UniProt accession: Q8N114
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PSEC0133, SCOTIN, SHISA5
Length: 240 residues
Disorder content (fraction disordered): 0.4791666666666667
Curated region start positions: 126, 126, 150, 150, 126, 150, 150, 150, 150, 126
Curated region end positions: 240, 240, 177, 177, 240, 177, 177, 177, 177, 240
Curated region terms: disorder, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, molecular condensate scaffold activity, regulation of ER to Golgi vesicle-mediated transport, regulation of COPII vesicle uncoating, positive regulation of endoplasmic reticulum unfolded protein response, positive regulation of response to endoplasmic reticulum stress
Domain/feature annotations: Shisa, N-terminal domain
Sequence:
MTAPVPAPRILLPLLLLLLLTPPPGARGEVCMASRGLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPAYHETLAGGAAAPYPASQPPYNPAYMDAPKAAL
Protein: AP2 domain transcription factor AP2-I, putative
UniProt accession: A0A564ZT73
Organism: Plasmodium vivax
Taxonomy: Eukaryota, Sar, Alveolata, Apicomplexa, Aconoidasida, Haemosporida, Plasmodiidae, Plasmodium, Plasmodium (Plasmodium)
Gene names: PVP01_0807400
Length: 1397 residues
Disorder content (fraction disordered): 0.07874015748031496
Curated region start positions: 29, 148
Curated region end positions: 56, 229
Curated region terms: disorder, disorder
Domain/feature annotations: AP2 domain, AP2 domain, AP2-coincident C-terminal
Cross-references: PDB:8RWU
Sequence:
MEALTTDKDMSIKNEERNENGTDLLIGLASLNEHEGEVAYDKKEDAEISMHMNEQDKLDVPSLVEICKQQLIVILKDMCADSNSSDEKASFMYHLNRLRSAVTVVDLHNYIAVFGPCLSYNKLPSTWNISVCDYLKQQLNILRAADSQQSSSNHVSYLELHNDYEDIIHDKKGNATTTASNSMQGNMNSNNLNSQLSMKGSSIHMNSANSTSNVSGNATGNASGHISINAEGGNLGCFTLGDHEDSNIVEDYYDCLMRTNLSDDSPNCLKYMMNSKNDSLSNTEVENVISYLKKYEVKANKNYCSLEEELKYSKDSDFEYQEDYLKDKTLYDSDLDDNNLFDSNLISSSRNMNDSGSSMMNMNLSIPNSGSANNNNSNNLSGKNYNMKYDSMKKNNSDVMNTWTRACTEGHPEYLPRIPGVRFNPKKQQWLAAWNDNTREIRRYFSVKQYGFEQARILAVKARQEAEKAGARCKPMFHVHGRKTVDSAANEAMKNNNDMGMEDGTMGNNNMGGSGVGGSMGMMSGSGNNASHAGTNAAMNSGGMSTGGTHEHMNKKDHLKNENNKGIKRGRGRPPKRKLSEDSQLSLDDMEQTLCRNGENADLMEAIDSFDKNCTRPMKGVSYNDRKGSWLAYWSIGKNFQMRRFPIKKLGFEKAKELAIQCRLEAEQAGATTTENRTKRIRNLLTMNSENTMDVMMDMNSLDPEDNLNDTNKNMNGNMIMSQMHHHYNAHGMNNNNNMHPNKMPHSDCQESENDYSPTKRTRAPRGRRMESLTARASALTPVEGVRFDPYSYSWFAKYLENENSKEPKISKYLLKKWGFNKAHSLAVHTVKCAYKAVPFTDEELINIFNVDSKNLMNNQNSLMNLAFKDTYGNNAGANGNAYNANNYGAMGVSSSANGALMGNMGYMNGAMGGAVGMDHVVGGMPIGGVSGVSGGNFAQSMGAYKGGVNAHGIMNSMGNSGGEKNADMGNMNDEETTIGNGSSNNANNMLSGMDGANGMLNSVEGANNMNAASKMGIMNGCAYNYSGGSSAVNDSAGGAVAGAGAATVGAATVGAATVGAATVGAAGQNNFHHGGLLPNSGIVVGAGLGENNVNGPSSMKGNATIANGVNVYMNEQMGLGANYSGKSFPSGEVLVAPGTSSAMMDDENPKVLNKAHLMESSNGAGNNAGGSVLQNSSVDNYLVVSECVLNNNNRKVGGAHVGNKTIGGAAAAAAAAFGHHHMEDPAVVGVVRLNEMHMNAENDINANQSNTQYGIASTGSNMNMNAEPVMSKAMVNSASGSVNLGTNKDSTGSIMEGRDVLDNSRGAEHPLEQRKFVNIMNESGNIDSGVSGVSGDSGANSSYANNNPYGPNAGANFNSYDGENAGAANMIGSNANELNESSMYYMSVKPEIKTEQ
Protein: Protein kinase OspG
UniProt accession: Q99PZ6
Organism: Shigella flexneri
Taxonomy: Bacteria, Pseudomonadota, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Shigella
Gene names: CP0227, SFLP087, ospG, pWR501_0237
Length: 196 residues
Disorder content (fraction disordered): 0.12755102040816327
Dataset labels: Bacterial virulence-related proteins
Curated region start positions: 1, 1
Curated region end positions: 25, 25
Curated region terms: disorder, flexible N-terminal tail
Domain/feature annotations: Protein kinase OspG, kinase domain
Cross-references: PDB:4BVU
Sequence:
MKITSTIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNRKYL
Protein: Poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase TarS
UniProt accession: A0A0H3JPC6
Organism: Staphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomy: Bacteria, Bacillati, Bacillota, Bacilli, Bacillales, Staphylococcaceae, Staphylococcus
Gene names: SAV0258, tarS
Length: 573 residues
Disorder content (fraction disordered): 0.019197207678883072
Dataset labels: Bacterial virulence-related proteins
Curated region start positions: 206, 208, 206
Curated region end positions: 216, 213, 216
Curated region terms: disorder to order, hydrolase activity, acting on glycosyl bonds, disorder
Domain/feature annotations: Glycosyl transferase family 2, TarS beta-glycosyltransferase C-terminal domain 1, Glycosyl transferase TarS linker domain, TarS C-terminal domain 2
Cross-references: PDB:5TZI, PDB:5TZJ
Sequence:
MMKFSVIVPTYNSEKYITELLNSLAKQDFPKTEFEVVVVDDCSTDQTLQIVEKYRNKLNLKVSQLETNSGGPGKPRNVALKQAEGEFVLFVDSDDYINKETLKDAAAFIDEHHSDVLLIKMKGVNGRGVPQSMFKETAPEVTLLNSRIIYTLSPTKIYRTALLKDNDIYFPEELKSAEDQLFTMKAYLNANRISVLSDKAYYYATKREGEHMSSAYVSPEDFYEVMRLIAVEILNADLEEAHKDQILAEFLNRHFSFSRTNGFSLKVKLEEQPQWINALGDFIQAVPERVDALVMSKLRPLLHYARAKDIDNYRTVEESYRQGQYYRFDIVDGKLNIQFNEGEPYFEGIDIAKPKVKMTAFKFDNHKIVTELTLNEFMIGEGHYDVRLKLHSRNKKHTMYVPLSVNANKQYRFNIMLEDIKAYLPKEKIWDVFLEVQIGTEVFEVRVGNQRNKYAYTAETSALIHLNNDFYRLTPYFTKDFNNISLYFTAITLTDSISMKLKGKNKIILTGLDRGYVFEEGMASVVLKDDMIMGMLSQTSENEVEILLSKDIKKRDFKNIVKLNTAHMTYSLK
Protein: PE family protein PE8
UniProt accession: L7N667
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomy: Bacteria, Bacillati, Actinomycetota, Actinomycetes, Mycobacteriales, Mycobacteriaceae, Mycobacterium, Mycobacterium tuberculosis complex
Gene names: PE8, Rv1040c
Length: 275 residues
Disorder content (fraction disordered): 0.05454545454545454
Dataset labels: Bacterial virulence-related proteins
Curated region start positions: 85
Curated region end positions: 99
Curated region terms: disorder
Domain/feature annotations: PE family, PPE-SVP subfamily C-terminal region
Cross-references: PDB:5XFS
Sequence:
MSFLKTVPEELTAAAAQLGTIGAAMAAQNAAAAAPTTAIAPAALDEVSALQAALFTAYGTFYQQVSAEAQAMHDMFVNTLGISAGTYGVTESLNSSAAASPLSGITGEASAIIQATTGLFPPELSGGIGNILNIGAGNWASATSTLIGLAGGGLLPAEEAAEAASALGGEAALGELGALGAAEAALGEAGIAAGLGSASAIGMLSVPPAWAGQATLVSTTSTLPGAGWTAAAPQAAAGTFIPGMPGVASAARNSAGFGAPRYGVKPIVMPKPATV