LiteFold/DisProt huggingface dataset:
Protein: Anaphase-promoting complex subunit hcn1
UniProt accession: O13916
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Taphrinomycotina, Schizosaccharomycetes, Schizosaccharomycetales, Schizosaccharomycetaceae, Schizosaccharomyces
Gene names: SPAC23C11.12, hcn1
Length: 80 residues
Disorder content (fraction disordered): 0.7
Curated region start positions: 25
Curated region end positions: 80
Curated region terms: disorder
Domain/feature annotations: Anaphase-promoting complex APC subunit CDC26
Sequence:
MLRRNPTAIQITAEDVLAYDEEKLRQTLDSESTTEEALQKNEESTRLSPEKKKIIRERRIGITQIFDSSMHPSQGGAAQS
Protein: Vesicle-associated membrane protein-associated protein B/C
UniProt accession: O95292
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: UNQ484/PRO983, VAPB
Length: 243 residues
Disorder content (fraction disordered): 0.6172839506172839
Dataset labels: Age-related disorders proteins
Curated region start positions: 1, 1, 125, 125, 1, 1, 1, 1
Curated region end positions: 125, 125, 150, 150, 125, 125, 125, 125
Curated region terms: disorder, order to disorder, disorder, flexible linker, disorder, order to disorder, order, order
Domain/feature annotations: Immunoglobulins, MSP (Major sperm protein) domain
Sequence:
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL
Protein: C-X-C chemokine receptor type 4
UniProt accession: P61073
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CXCR4
Length: 352 residues
Disorder content (fraction disordered): 0.1590909090909091
Dataset labels: Autophagy-related proteins, Cancer-related proteins
Curated region start positions: 1, 1, 304, 1, 1, 313
Curated region end positions: 26, 24, 319, 27, 34, 325
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: Rhodopsin 7-helix transmembrane proteins, 7 transmembrane receptor (rhodopsin family), CXCR4 Chemokine receptor N terminal
Cross-references: PDB:3ODU, PDB:3OE0, PDB:3OE6, PDB:3OE8, PDB:3OE9
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Protein: Histone H2B
UniProt accession: P02283
Organism: Drosophila melanogaster
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Arthropoda, Hexapoda, Insecta, Pterygota, Neoptera, Endopterygota, Diptera, Brachycera, Muscomorpha, Ephydroidea, Drosophilidae, Drosophila, Sophophora
Gene names: CG17949, CG33868, CG33870, CG33872, CG33874, CG33876, CG33878, CG33880, CG33882, CG33884, CG33886, CG33888, CG33890, CG33892, CG33894, CG33896, CG33898, CG33900, CG33902, CG33904, CG33906, CG33908, CG33910, His2B, His2B:CG17949, His2B:CG33868, His2B:CG33870, His2B:CG33872, His2B:CG33874, His2B:CG33876, His2B:CG33878, His2B:CG33880, His2B:CG33882, His2B:CG33884, His2B:CG33886, His2B:CG33888, His2B:CG33890, His2B:CG33892, His2B:CG33894, His2B:CG33896, His2B:CG33898, His2B:CG33900, His2B:CG33902, His2B:CG33904, His2B:CG33906, His2B:CG33908, His2B:CG33910
Length: 123 residues
Disorder content (fraction disordered): 0.2682926829268293
Curated region start positions: 2, 2, 2
Curated region end positions: 27, 34, 34
Curated region terms: disorder, disorder, flexible N-terminal tail
Domain/feature annotations: Histone, subunit A, Core histone H2A/H2B/H3/H4 domain
Cross-references: PDB:2PYO, PDB:7PJ1
Sequence:
MPPKTSGKAAKKAGKAQKNITKTDKKKKRKRKESYAIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
Protein: Transforming growth factor beta-1 proprotein
UniProt accession: P01137
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TGFB, TGFB1
Length: 390 residues
Disorder content (fraction disordered): 0.05641025641025641
Dataset labels: Autophagy-related proteins, Extracellular matrix proteins
Curated region start positions: 240, 257, 257
Curated region end positions: 261, 260, 260
Curated region terms: disorder, selective autophagy, protein binding
Domain/feature annotations: Cystine-knot cytokines, 2.60.120.970, Transforming growth factor beta like domain, TGF-beta propeptide
Sequence:
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Protein: 60S acidic ribosomal protein P1
UniProt accession: P05386
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: RPLP1, RRP1
Length: 114 residues
Disorder content (fraction disordered): 0.45614035087719296
Curated region start positions: 63, 63
Curated region end positions: 114, 114
Curated region terms: disorder, protein binding
Domain/feature annotations: 1.10.10.1410, 60s Acidic ribosomal protein
Cross-references: PMCID:PMC3794596
Sequence:
MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD
Protein: X-ray repair cross-complementing protein 6
UniProt accession: P12956
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: G22P1, XRCC6
Length: 609 residues
Disorder content (fraction disordered): 0.1264367816091954
Curated region start positions: 533
Curated region end positions: 609
Curated region terms: disorder
Domain/feature annotations: von Willebrand factor, type A domain, Ku70, bridge and pillars, SAP domain, 2.40.290.10, 1.10.1600.10, SAP domain, Ku70/Ku80 beta-barrel domain, Ku70/Ku80 C-terminal arm, Ku70/Ku80 N-terminal alpha/beta domain
Sequence:
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELLEALTKHFQD
Protein: X-ray repair cross-complementing protein 5
UniProt accession: P13010
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: G22P2, XRCC5
Length: 732 residues
Disorder content (fraction disordered): 0.0273224043715847
Curated region start positions: 546
Curated region end positions: 565
Curated region terms: disorder
Domain/feature annotations: Ku, C-terminal domain, 2.40.290.10, von Willebrand factor, type A domain, 1.10.1600.10, Ku70/Ku80 beta-barrel domain, Ku70/Ku80 C-terminal arm, Ku70/Ku80 N-terminal alpha/beta domain, Ku C terminal domain like
Sequence:
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI
Protein: U6 snRNA-associated Sm-like protein LSm7
UniProt accession: P53905
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: LSM7, N1202, N1780, YNL147W
Length: 115 residues
Disorder content (fraction disordered): 0.3217391304347826
Curated region start positions: 1, 105
Curated region end positions: 26, 115
Curated region terms: disorder, disorder
Domain/feature annotations: 2.30.30.100, LSM domain
Cross-references: PDB:4M75, PDB:4M77, PDB:4M78, PDB:4M7A, PDB:4M7D
Sequence:
MHQQHSKSENKPQQQRKKFEGPKREAILDLAKYKDSKIRVKLMGGKLVIGVLKGYDQLMNLVLDDTVEYMSNPDDENNTELISKNARKLGLTVIRGTILVSLSSAEGSDVLYMQK
Protein: Transcription initiation factor TFIID subunit 6
UniProt accession: P49848
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TAF2E, TAF6, TAFII70
Length: 677 residues
Disorder content (fraction disordered): 0.6750369276218612
Dataset labels: NDDs-related proteins
Curated region start positions: 1, 437
Curated region end positions: 216, 677
Curated region terms: disorder, disorder
Domain/feature annotations: Histone, subunit A, TAF6, C-terminal HEAT repeat domain, TATA box binding protein associated factor (TAF), TAF6 C-terminal HEAT repeat domain
Cross-references: EMDB:3305, PDB:5FUR
Sequence:
MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP
Protein: 5' exonuclease Apollo
UniProt accession: Q9H816
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DCLRE1B, SNM1B
Length: 532 residues
Disorder content (fraction disordered): 0.041353383458646614
Curated region start positions: 314
Curated region end positions: 335
Curated region terms: disorder
Domain/feature annotations: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like, 3.40.50.12650, DNA repair metallo-beta-lactamase
Cross-references: PDB:5AHO
Sequence:
MNGVLIPHTPIAVDFWSLRRAGTARLFFLSHMHSDHTVGLSSTWARPLYCSPITAHLLHRHLQVSKQWIQALEVGESHVLPLDEIGQETMTVTLLDANHCPGSVMFLFEGYFGTILYTGDFRYTPSMLKEPALTLGKQIHTLYLDNTNCNPALVLPSRQEAAHQIVQLIRKHPQHNIKIGLYSLGKESLLEQLALEFQTWVVLSPRRLELVQLLGLADVFTVEEKAGRIHAVDHMEICHSNMLRWNQTHPTIAILPTSRKIHSSHPDIHVIPYSDHSSYSELRAFVAALKPCQVVPIVSRRPCGGFQDSLSPRISVPLIPDSVQQYMSSSSRKPSLLWLLERRLKRPRTQGVVFESPEESADQSQADRDSKKAKKEKLSPWPADLEKQPSHHPLRIKKQLFPDLYSKEWNKAVPFCESQKRVTMLTAPLGFSVHLRSTDEEFISQKTREEIGLGSPLVPMGDDDGGPEATGNQSAWMGHGSPLSHSSKGTPLLATEFRGLALKYLLTPVNFFQAGYSSRRFDQQVEKYHKPC
Protein: Activating transcription factor 7-interacting protein 1
UniProt accession: Q6VMQ6
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ATF7IP, MCAF, MCAF1
Length: 1270 residues
Disorder content (fraction disordered): 0.02125984251968504
Curated region start positions: 938
Curated region end positions: 964
Curated region terms: disorder
Domain/feature annotations: Immunoglobulins, ATF-interacting protein binding domain, Fibronectin-III type domain
Sequence:
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSTGPQLTVHHRPPQVHTEPPRPVHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEEPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSTQSS
Protein: Male-specific lethal 1 homolog
UniProt accession: Q68DK7
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MSL1, MSL1L1
Length: 614 residues
Disorder content (fraction disordered): 0.017915309446254073
Curated region start positions: 558
Curated region end positions: 568
Curated region terms: disorder
Domain/feature annotations: 1.20.5.170, PEHE domain, Dimerisation domain of Male-specific-Lethal 1
Sequence:
MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDEPGAAEAHFLPRHRKLKEPGPPLASSQGGSPAPSPAGCGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPAAAGAGCSPRPKYQAVLPIQTGSLVAAAKEPTPWAGDKGGAASPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSMRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEIEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRLEIQKKQTPHRTCRK
Protein: Male-specific lethal 3 homolog
UniProt accession: Q8N5Y2
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MSL3, MSL3L1
Length: 521 residues
Disorder content (fraction disordered): 0.061420345489443376
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 226, 508
Curated region end positions: 246, 518
Curated region terms: disorder, disorder
Domain/feature annotations: MRG domain, MRG domain, 2.30.30.140, MRG, MSL3 chromodomain-like
Cross-references: PDB:2Y0N
Sequence:
MSASEGMKFKFHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARLRSTGRKKKRCRLPGVDSVLKGLPTEEKDENDENSLSSSSDCSENKDEEISEESDIEEKTEVKEEPELQTRREMEERTITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHVMPHANMNVHYIPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQYKKVTSSKFFLPIKESATSTNRSQEELSPSPPLLNPSTPQSTESQPTTGEPATPKRRKAEPEALQSLRRSTRHSANCDRLSESSASPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKEGSAVFAGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY
Protein: Amyloid-beta precursor protein
UniProt accession: P05067
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: A4, AD1, APP
Length: 770 residues
Disorder content (fraction disordered): 0.05194805194805195
Dataset labels: Condensates-related proteins, Age-related disorders proteins
Curated region start positions: 672, 672, 672, 672, 672, 672, 672, 672
Curated region end positions: 711, 711, 711, 686, 711, 711, 711, 711
Curated region terms: disorder, amyloid fibril formation, disorder to order, disorder, disorder, disorder, amyloid fibril formation, amyloid fibril formation
Domain/feature annotations: Amyloidogenic glycoprotein, copper-binding domain, Amyloid precursor protein, E2 domain, Amyloidogenic glycoprotein, heparin-binding domain, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB), Amyloidogenic glycoprotein, amyloid-beta peptide, Pancreatic trypsin inhibitor Kunitz domain, Kunitz/Bovine pancreatic trypsin inhibitor domain, Amyloid A4 N-terminal heparin-binding, Beta-amyloid peptide (beta-APP), Beta-amyloid precursor protein C-terminus, Copper-binding of amyloid precursor, CuBD, E2 domain of amyloid precursor protein
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Protein: Histone-binding protein RBBP7
UniProt accession: Q16576
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: RBAP46, RBBP7
Length: 425 residues
Disorder content (fraction disordered): 0.08941176470588236
Curated region start positions: 90, 409
Curated region end positions: 110, 425
Curated region terms: disorder, disorder
Domain/feature annotations: YVTN repeat-like/Quinoprotein amine dehydrogenase, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, Histone-binding protein RBBP4 or subunit C of CAF1 complex
Sequence:
MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSELEGQGS
Protein: Iota-conotoxin RXIA
UniProt accession: Q7Z094
Organism: Conus radiatus
Taxonomy: Eukaryota, Metazoa, Spiralia, Lophotrochozoa, Mollusca, Gastropoda, Caenogastropoda, Neogastropoda, Conoidea, Conidae, Conus, Phasmoconus
Length: 46 residues
Disorder content (fraction disordered): 0.2391304347826087
Curated region start positions: 36
Curated region end positions: 46
Curated region terms: disorder
Domain/feature annotations: Conotoxin I-superfamily
Sequence:
GPSFCKADEKPCEYHADCCNCCLSGICAPSTNWILPGCSTSSFFKI
Protein: ATM interactor
UniProt accession: O43313
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ATMIN, KIAA0431, ZNF822
Length: 823 residues
Disorder content (fraction disordered): 0.5613608748481167
Curated region start positions: 362, 362
Curated region end positions: 823, 823
Curated region terms: disorder, protein binding
Domain/feature annotations: Classic Zinc Finger, ASCIZ first and second C2H2 zinc finger domains, ASCIZ first and second C2H2 zinc finger domains, ASCIZ third C2HC zinc finger domain, ASCIZ forth C2H2 zinc finger domain
Sequence:
MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF
Protein: Antitoxin HigA-2
UniProt accession: Q9KMA5
Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Vibrionales, Vibrionaceae, Vibrio
Gene names: VC_A0469, higA-2
Length: 104 residues
Disorder content (fraction disordered): 0.34615384615384615
Dataset labels: Unicellular toxins and antitoxins
Curated region start positions: 1, 1, 1, 1, 3, 3, 1, 3, 3
Curated region end positions: 36, 36, 36, 36, 33, 22, 36, 36, 36
Curated region terms: disorder, disorder, disorder to order, disorder, disorder, toxin sequestering activity, protein binding, disorder to order, protein binding
Domain/feature annotations: lambda repressor-like DNA-binding domains, Antitoxin component of bacterial toxin-antitoxin system, MqsA
Cross-references: PDB:5J9I, PDB:5JAA
Sequence:
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVPNGQAVTLLKLVQRHPETLSHIAEL
Protein: Antitoxin MazE
UniProt accession: P0AE72
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW2754, b2783, chpAI, chpR, mazE
Length: 82 residues
Disorder content (fraction disordered): 0.4268292682926829
Dataset labels: Unicellular toxins and antitoxins
Curated region start positions: 48, 51, 51, 48, 48, 51, 68, 68, 68, 50
Curated region end positions: 82, 82, 82, 76, 76, 82, 82, 82, 82, 82
Curated region terms: disorder, disorder, disorder, disorder to order, protein binding, DNA binding, disorder to order, protein binding, toxin sequestering activity, protein binding
Domain/feature annotations: 2.10.260.10, Antidote-toxin recognition MazE, bacterial antitoxin
Cross-references: BMRB:25093, PDB:1MVF, PDB:1UB4, PDB:2MRN, PDB:2MRU, PDB:5CQX, PDB:5CQY
Sequence:
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKEVW