LiteFold/DisProt huggingface dataset:
Protein: Presenilin-1
UniProt accession: P49768
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: AD3, PS1, PSEN1, PSNL1
Length: 467 residues
Disorder content (fraction disordered): 0.41541755888650966
Dataset labels: Age-related disorders proteins
Curated region start positions: 1, 262
Curated region end positions: 77, 378
Curated region terms: disorder, disorder
Domain/feature annotations: Presenilin, Presenilin
Cross-references: EMDB:3061, PDB:5A63
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
Protein: Eukaryotic translation initiation factor 4E-binding protein 2
UniProt accession: Q13542
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: EIF4EBP2
Length: 120 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 18, 18, 18, 1
Curated region end positions: 120, 120, 62, 62, 62, 120
Curated region terms: disorder, protein binding, phosphorylation display site, disorder to order, order, protein binding
Domain/feature annotations: Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Cross-references: IntAct:EBI-16080855, PDB:2MX4
Sequence:
MSSSAGSGHQPSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIEDSKVEVNNLNNLNNHDRKHAVGDDAQFEMDI
Protein: Protein Tat
UniProt accession: Q98XH7
Organism: Human immunodeficiency virus 1
Taxonomy: Viruses, Riboviria, Pararnavirae, Artverviricota, Revtraviricetes, Ortervirales, Retroviridae, Orthoretrovirinae, Lentivirus
Gene names: tat
Length: 72 residues
Disorder content (fraction disordered): 0.20833333333333337
Dataset labels: Viral proteins, RNA-binding proteins
Curated region start positions: 6, 2, 6, 6, 2, 2
Curated region end positions: 14, 16, 14, 14, 16, 16
Curated region terms: protein binding, protein binding, protein binding, molecular adaptor activity, molecular adaptor activity, disorder
Domain/feature annotations: Tat domain, Transactivating regulatory protein (Tat)
Cross-references: PDB:3O6L, PDB:3O6M
Sequence:
MEPVDPKLEPWKHPGSQPKTACNNCYCKRCCLHCQVCFMTKGLGIYYGRKKRRQRRRASQDRQTHQDSLSEQ
Protein: CP12
UniProt accession: Q6BBK3
Organism: Synechococcus elongatus (strain PCC 7942)
Taxonomy: Bacteria, Cyanobacteria, Synechococcales, Synechococcaceae, Synechococcus
Gene names: Synpcc7942_0361, cp12
Length: 75 residues
Disorder content (fraction disordered): 0.6933333333333334
Curated region start positions: 1, 1, 1
Curated region end positions: 52, 52, 52
Curated region terms: disorder, disorder to order, protein binding
Domain/feature annotations: CP12 domain
Cross-references: imex:DIP-59423N
Sequence:
MSDIQEKIEQARQEAHAISEEKGATSPDAAAAWDAVEELQAEAAHQRQQKSETEPFFGDYCSENPDAAECLIYDD
Protein: Late embryogenesis abundant protein 18
UniProt accession: Q96273
Organism: Arabidopsis thaliana
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, rosids, malvids, Brassicales, Brassicaceae, Camelineae, Arabidopsis
Gene names: At2g35300, LEA18, LEA4-2
Length: 97 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1
Curated region end positions: 97, 97, 97
Curated region terms: disorder, protein stabilization, cold acclimation
Domain/feature annotations: Late embryogenesis abundant (LEA) group 1
Sequence:
MQSAKEKISDMASTAKEKLNIGGAKAQGHAEKTMARTKKEKKLAQEREKSKEAQAKADLHQSKAEHAADAQVHGHHLPGHSTYPTRATGANYPPGQI
Protein: Dehydrin HIRD11
UniProt accession: Q9SLJ2
Organism: Arabidopsis thaliana
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, rosids, malvids, Brassicales, Brassicaceae, Camelineae, Arabidopsis
Gene names: At1g54410, F20D21.23, HIRD11, SRC1
Length: 98 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1
Curated region end positions: 98
Curated region terms: disorder
Sequence:
MAGLINKIGDALHIGGGNKEGEHKKEEEHKKHVDEHKSGEHKEGIVDKIKDKIHGGEGKSHDGEGKSHDGEKKKKKDKKEKKHHDDGHHSSSSDSDSD
Protein: Dehydrodolichyl diphosphate synthase complex subunit Nus1
UniProt accession: Q99LJ8
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: D10Ertd438e, Ngbr, Nus1
Length: 297 residues
Disorder content (fraction disordered): 0.24915824915824916
Curated region start positions: 47, 47, 47, 47, 47, 47
Curated region end positions: 120, 120, 120, 120, 120, 120
Curated region terms: disorder, disorder to order, disorder, disorder to order, disorder, disorder to order
Domain/feature annotations: Decaprenyl diphosphate synthase-like, Putative undecaprenyl diphosphate synthase
Sequence:
MTGLYELVWRVLHALLCLHLTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPRAVGRNRRHHRHPHGGPGPGPGPAATHPRLRWRADVRSLQKLPVHMGLLVTEEVQEPSFSDIASLVVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGQDCSKYSAEFANSNDKDDQDLNCPSAVKVLSPEDGKADIVRAAQDFCQLVAQQQRKPTDLDVDLLGSLLSSHGFPDPDLVLKFGPVDSTLGFLPWQIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
Protein: Major viral transcription factor ICP4
UniProt accession: P08392
Organism: Human herpesvirus 1 (strain 17)
Taxonomy: Viruses, Duplodnaviria, Heunggongvirae, Peploviricota, Herviviricetes, Herpesvirales, Herpesviridae, Alphaherpesvirinae, Simplexvirus
Gene names: ICP4, IE175, RS1
Length: 1298 residues
Disorder content (fraction disordered): 0.02465331278890601
Dataset labels: Viral proteins
Curated region start positions: 258, 258, 258, 258
Curated region end positions: 286, 289, 287, 289
Curated region terms: disorder, disorder, DNA binding, flexible linker
Domain/feature annotations: Herpesvirus ICP4-like protein N-terminal region, Herpesvirus ICP4-like protein C-terminal region
Cross-references: BMRB:26957, PDB:5MHK
Sequence:
MASENKQRPGSPGPTDGPPPTPSPDRDERGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFRADDDDGDEYDDAADAAGDRAPARGREREAPLRGAYPDPTDRLSPRPPAQPPRRRRHGRWRPSASSTSSDSGSSSSSSASSSSSSSDEDEDDDGNDAADHAREARAVGRGPSSAAPAAPGRTPPPPGPPPLSEAAPKPRAAARTPAASAGRIERRRARAAVAGRDATGRFTAGQPRRVELDADATSGAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACFRISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAALTGAAGSPGAGADDEGVAAVAAAAPGERAVPAGYGAAGILAALGRLSAAPASPAGGDDPDAARHADADDDAGRRAQAGRVAVECLAACRGILEALAEGFDGDLAAVPGLAGARPASPPRPEGPAGPASPPPPHADAPRLRAWLRELRFVRDALVLMRLRGDLRVAGGSEAAVAAVRAVSLVAGALGPALPRDPRLPSSAAAAAADLLFDNQSLRPLLAAAASAPDAADALAAAAASAAPREGRKRKSPGPARPPGGGGPRPPKTKKSGADAPGSDARAPLPAPAPPSTPPGPEPAPAQPAAPRAAAAQARPRPVAVSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAPAAQAACGGGDDDDNPHPHGAAGGRLFGPLRASGPLRRMAAWMRQIPDPEDVRVVVLYSPLPGEDLAGGGASGGPPEWSAERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYLACELLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDAMAPGAPDFCEEEAHSHAACARWGLGAPLRPVYVALGREAVRAGPARWRGPRRDFCARALLEPDDDAPPLVLRGDDDGPGALPPAPPGIRWASATGRSGTVLAAAGAVEVLGAEAGLATPPRREVVDWEGAWDEDDGGAFEGDGVL
Protein: Polyglutamine-binding protein 1
UniProt accession: O60828
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: JM26, NPW38, PQBP1
Length: 265 residues
Disorder content (fraction disordered): 1
Dataset labels: NDDs-related proteins
Curated region start positions: 82, 1, 1, 1, 1, 1, 223, 223, 223, 220, 238, 223, 238, 1, 1, 94, 94, 1, 193, 1
Curated region end positions: 265, 265, 265, 265, 265, 265, 265, 265, 265, 265, 260, 243, 260, 265, 265, 265, 265, 265, 265, 265
Curated region terms: disorder, pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, pre-molten globule, protein binding, protein binding, protein binding, disorder, disorder to order, disorder, protein binding, disorder, disorder, disorder, disorder, protein binding, protein binding, protein binding
Domain/feature annotations: 2.20.70.10, Glutaredoxin
Cross-references: PDB:4BWQ, PDB:4BWS, PDB:4CDO
Sequence:
MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSCGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRGHDKSDRSHEKLDRGHDKSDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHRREELAPYPKSKKAVSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD
Protein: Cyclin-dependent kinase 9
UniProt accession: P50750
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: CDC2L4, CDK9, TAK
Length: 372 residues
Disorder content (fraction disordered): 0.1935483870967742
Dataset labels: NDDs-related proteins
Curated region start positions: 87, 328, 328, 345, 259, 88, 330
Curated region end positions: 98, 372, 338, 357, 273, 97, 372
Curated region terms: disorder, disorder, disorder to order, nucleus localization, disorder, disorder, kinase activity
Domain/feature annotations: Transferase(Phosphotransferase) domain 1, Phosphorylase Kinase; domain 1, Protein kinase domain
Cross-references: PDB:3BLH, PDB:3BLQ, PDB:3BLR, PDB:3TNH, PDB:3TNI , PDB:4EC8, PDB:4EC9
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
Protein: Calcium-binding mitochondrial carrier protein SCaMC-1
UniProt accession: Q6NUK1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: APC1, MCSC1, SCAMC1, SLC25A24
Length: 477 residues
Disorder content (fraction disordered): 0.18867924528301888
Curated region start positions: 50, 50, 99, 99, 159, 1, 177, 99, 159, 68
Curated region end positions: 78, 78, 109, 109, 170, 21, 193, 109, 170, 79
Curated region terms: disorder, disorder to order, disorder, calcium ion binding, disorder, disorder, disorder, disorder to order, disorder to order, calcium ion binding
Domain/feature annotations: Mitochondrial carrier domain, EF-hand, EF-hand, Mitochondrial carrier protein, Mitochondrial carrier protein, Mitochondrial carrier protein, EF-hand domain pair, EF-hand domain pair
Cross-references: PDB:4N5X
Sequence:
MLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVDIGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK
Protein: Suppressor of fused homolog
UniProt accession: Q9UMX1
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SUFU, UNQ650/PRO1280
Length: 484 residues
Disorder content (fraction disordered): 0.16942148760330578
Dataset labels: Cancer-related proteins, NDDs-related proteins
Curated region start positions: 279
Curated region end positions: 360
Curated region terms: disorder
Domain/feature annotations: Sufu, C-terminal domain, Suppressor of fused protein (SUFU), Suppressor of Fused Gli/Ci N terminal binding domain
Cross-references: PDB:4BL8
Sequence:
MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAHDRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH
Protein: Polycomb complex protein BMI-1
UniProt accession: P25916
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Bmi-1, Bmi1, Pcgf4
Length: 324 residues
Disorder content (fraction disordered): 0.4166666666666667
Curated region start positions: 106
Curated region end positions: 240
Curated region terms: disorder
Domain/feature annotations: Zinc/RING finger domain, C3HC4 (zinc finger), Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1, Zinc finger, C3HC4 type (RING finger), RAWUL domain RING finger- and WD40-associated ubiquitin-like
Sequence:
MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEEKRIITDDEIISLSIEFFDQSRLDRKVNKEKPKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKMSHQRDGLTNAGELESDSGSDKANSPAGGVPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSANHQSSFASRPRKSSLNGSSATSSG
Protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
UniProt accession: O60741
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: BCNG1, HCN1
Length: 890 residues
Disorder content (fraction disordered): 0.10449438202247192
Dataset labels: NDDs-related proteins
Curated region start positions: 1
Curated region end positions: 93
Curated region terms: disorder
Domain/feature annotations: Jelly Rolls, Helix hairpin bin, 1.10.287.70, Cyclic nucleotide-binding domain, Ion transport protein, Ion transport protein N-terminal
Cross-references: EMDB:EMD-8511, EMDB:EMD-8512, PDB:5U6O, PDB:5U6P
Sequence:
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL
Protein: Mothers against decapentaplegic homolog 2
UniProt accession: Q15796
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MADH2, MADR2, SMAD2
Length: 467 residues
Disorder content (fraction disordered): 0.10920770877944326
Dataset labels: Cancer-related proteins
Curated region start positions: 241, 457, 457, 463, 463, 18, 18, 18
Curated region end positions: 264, 467, 467, 467, 467, 33, 33, 33
Curated region terms: disorder, disorder, disorder to order, phosphorylation display site, protein binding, disorder, disorder, disorder
Domain/feature annotations: 2.60.200.10, MH1 domain, MH2 domain
Cross-references: BMRB:27742, PDB:1DEV, PDB:1KHX
Sequence:
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
Protein: Fe-S cluster assembly protein DRE2
UniProt accession: P36152
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: DRE2, YKR071C
Length: 348 residues
Disorder content (fraction disordered): 0.33045977011494254
Curated region start positions: 234, 234
Curated region end positions: 348, 348
Curated region terms: disorder, molecular adaptor activity
Domain/feature annotations: Fe-S cluster assembly protein Dre2, N-terminal domain, Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, Fe-S cluster assembly protein DRE2 N-terminus
Sequence:
MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEENEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL
Protein: Fibronectin-binding protein
UniProt accession: Q01924
Organism: Streptococcus pyogenes
Taxonomy: Bacteria, Firmicutes, Bacilli, Lactobacillales, Streptococcaceae, Streptococcus
Gene names: Sfb
Length: 638 residues
Disorder content (fraction disordered): 0.3072100313479624
Curated region start positions: 396, 396
Curated region end positions: 591, 591
Curated region terms: disorder, order to disorder
Domain/feature annotations: Thioester domain, 1.10.150.480, Fibronectin binding repeat, Fibronectin binding repeat, Fibronectin binding repeat, Fibronectin binding repeat, Fibronectin binding repeat, Thioester domain
Sequence:
MNNKMFLNKEAGFLAHTKRKRRFAVTLVGVFFMLLASAGAIGFGQVAYAADEKTVPHRVSQNPEFPWYGYDFYKGPYTRYHNLQLNLNGSKTYQAYCFNLKRFEPKKEGSYFPNWYKRWDGSEETFVKYADNPRKDNESSRVIDVELEKNILRVLYNGYPNNGNGIMEGLEPLNAILVTQNAVWYYSDNSSIFNTDNFFTTEAKDLNIKPEQLSLMRVALKKLIDPKLSEESLKPVPSTFRLNIFESQDKLYQNLLSAEFVPENPPKPGETPEHGPKTPELDGTPIPEGPQRPNESLEPTLPPVMLDGQEVPEVPSESLEPALPPLMPELDGQEVPEVPSESLEPALPPLMPELDGQEVPEKPSVDLPIEDPRYEFNNKDQSPLAGESGETEYITEVYGNQQNPVDIDKKLPNETGFSGNMVETEDTKEPGVLMGGQSESVEFTKDTQTGMSGQTTPQVETEDTKEPGVLMGGQSESVEFTKDTQTGMSGQTASQVETEDTKEPGVLMGGQSESVEFTKDTQTGMSGQTTPQVETEDTKEPGVLMGGQSESVEFTKDTQTGMSGFSETVTIVEDTRPKLVFHFDNNEPKVEENREKPTKNITPILPATGDIENVLAFLGILILSVLPIFSLLKKQTKQ
Protein: HMG box-containing protein 1
UniProt accession: Q8R316
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Hbp1
Length: 516 residues
Disorder content (fraction disordered): 0.07170542635658915
Curated region start positions: 242, 358, 366, 366, 366, 358
Curated region end positions: 255, 380, 376, 376, 376, 380
Curated region terms: disorder, disorder, disorder to order, order, protein binding, protein binding
Domain/feature annotations: High mobility group box domain, HMG (high mobility group) box, Ataxin-1 and HBP1 module (AXH)
Cross-references: PDB:1S5R, PDB:1V06
Sequence:
MVWEVKTNQMPNAVQKLLLVMDKRAPGMSDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSAIYQLSSDVSHQEYPRSSWSQNTSDIPENTHREDEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSGPAFPHDHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTIWHCFLKGTRLCFHKESNKEWQDVEDFARAASCDNEEEIQMGTHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEIHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGGPGTGQEFSGSEFSKSCGSPGSSQLSSSSLYAKAVKSHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
Protein: Trinucleotide repeat-containing gene 6C protein
UniProt accession: Q9HCJ0
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: KIAA1582, TNRC6C
Length: 1936 residues
Disorder content (fraction disordered): 0.011363636363636364
Dataset labels: NDDs-related proteins
Curated region start positions: 1592, 1587, 1591, 1591, 1591, 1591, 1591
Curated region end positions: 1606, 1608, 1606, 1606, 1606, 1606, 1606
Curated region terms: protein binding, disorder, protein binding, protein binding, disorder to order, disorder to order, protein binding
Domain/feature annotations: 3.30.70.330, DNA helicase RuvA subunit, C-terminal domain, RNA recognition motif, UBA/TS-N domain, Argonaute hook, M domain of GW182, TNRC6-PABC binding domain
Cross-references: PDB:3KTP
Sequence:
MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTISSSNNGKRASASGQQPAASRYLPREVPPRFRQQEQKQLLKRGQPLPTGTLTSVSPTQGAGPAGVSPPPLPGAGTQHHPSKLQPDLSHSGLADHYENSHWGQQPTYRSEANCSWDKVIIDRTDKEAWPSITGTETESASECTTDTDSASNCGSENSSMATGSAQGNFTGHTKKTNGNNGTNGALVQSPSNQSALGAGGANSNGSAARVWGVATGSSSGLAHCSVSGGDGKMDTMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVATGNPSSICSPVSAIGQNMGNQNGNPTGTLGAWGNLLPQESTEPQTSTSQNVSFSAQPQNLNTDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAKQNGSSSAVQKEGSGGNAWDSGPPAGPGILAWGRGSGNNGVGNIHSGAWGHPSRSTSNGVNGEWGKPPNQHSNSDINGKGSTGWESPSVTSQNPTVQPGGEHMNSWAKAASSGTTASEGSSDGSGNHNEGSTGREGTGEGRRRDKGIIDQGHIQLPRNDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQASNSGGKNDGSIMNSTNTSSVSGWVNAPPAAVPANTGWGDSNNKAPSGPGVWGDSISSTAVSTAAAAKSGHAWSGAANQEDKSPTWGEPPKPKSQHWGDGQRSNPAWSAGGGDWADSSSVLGHLGDGKKNGSGWDADSNRSGSGWNDTTRSGNSGWGNSTNTKANPGTNWGETLKPGPQQNWASKPQDNNVSNWGGAASVKQTGTGWIGGPVPVKQKDSSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPVIQSSTTTNTTTTTTTTTSNTTHRVETPPPHQAGTQLNRSPLLGPVSSGWGEMPNVHSKTENSWGEPSSPSTLVDNGTAAWGKPPSSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGGDEMNLSTSQWEDEEGDVWNNAASQESTSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDHNGMAAKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTPSPFLPSPSLKLPLSHSALPSQALGGIASGLGMQNLNSSRQIPSGNLGMFGNSGAAQARTMQQPPQPPVQPLNSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGSMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKQPPPPPPPPHLSLHPSAGKSAMDSFPSHPQTPGLPDLQTKEQQSSPNTFAPYPLAGLNPNMNVNSMDMTGGLSVKDPSQSQSRLPQWTHPNSMDNLPSAASPLEQNPSKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVAGKLSDIKSTWSSGPTSHTQASLSHELWKVPRNSTAPTRPPPGLTNPKPSSTWGASPLGWTSSYSSGSAWSTDTSGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSASSQPRLSAAGSSHGLVRSDAGHWNAPCLGGKGSSELLWGGVPQYSSSLWGPPSADDSRVIGSPTPLTTLLPGDLLSGESL
Protein: Isoform ARTS of Septin-4
UniProt accession: O43236-6
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: C17orf47, PNUTL2, SEP4, SEPT4, SEPTIN4, hucep-7
Length: 274 residues
Disorder content (fraction disordered): 0.09854014598540146
Curated region start positions: 248, 248, 248, 248
Curated region end positions: 274, 274, 274, 274
Curated region terms: disorder, protein binding, disorder, protein binding
Sequence:
MIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGYGPSLRLLAPPGAVKGTGQEHQGQGCH