LiteFold/DisProt huggingface dataset:
Protein: Troponin I, fast skeletal muscle
UniProt accession: P48788
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: TNNI2
Length: 182 residues
Disorder content (fraction disordered): 0.4725274725274725
Curated region start positions: 97, 98
Curated region end positions: 182, 182
Curated region terms: disorder, disorder
Domain/feature annotations: 1.20.5.350, Troponin
Sequence:
MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES
Protein: E3 ubiquitin-protein ligase RBX1
UniProt accession: P62877
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: RBX1, RNF75, ROC1
Length: 108 residues
Disorder content (fraction disordered): 0.3611111111111111
Dataset labels: Condensates-related proteins
Curated region start positions: 12, 12, 12, 12, 12, 1
Curated region end positions: 39, 39, 39, 39, 39, 18
Curated region terms: disorder, disorder to order, disorder to order, protein binding, molecular adaptor activity, disorder
Domain/feature annotations: Zinc/RING finger domain, C3HC4 (zinc finger), RING-H2 zinc finger domain
Cross-references: PDB:1LDJ, PDB:1LDK, PDB:1U6G, PDB:2LGV
Sequence:
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
Protein: U4/U6 small nuclear ribonucleoprotein Prp4
UniProt accession: O43172
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PRP4, PRPF4
Length: 522 residues
Disorder content (fraction disordered): 0.32375478927203066
Dataset labels: RNA-binding proteins
Curated region start positions: 1, 1, 106, 106, 1, 1, 106, 107, 107, 107, 107
Curated region end positions: 169, 169, 169, 169, 98, 169, 169, 137, 137, 137, 137
Curated region terms: disorder, molten globule, protein binding, protein binding, protein binding, disorder, protein binding, disorder, order, disorder to order, protein binding
Domain/feature annotations: Pre-mRNA processing factor 4 domain, YVTN repeat-like/Quinoprotein amine dehydrogenase, YVTN repeat-like/Quinoprotein amine dehydrogenase, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, WD domain, G-beta repeat, pre-mRNA processing factor 4 (PRP4) like
Cross-references: PDB:1MZW
Sequence:
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
Protein: Cell cycle regulator of non-homologous end joining
UniProt accession: Q8BHZ5
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Cyren, Mri
Length: 157 residues
Disorder content (fraction disordered): 1
Curated region start positions: 1, 1, 1, 1, 1, 1, 143, 1, 1, 1, 1, 1, 1
Curated region end positions: 157, 157, 157, 157, 157, 17, 157, 157, 157, 157, 157, 157, 157
Curated region terms: disorder, disorder, protein homooligomerization, protein binding, DNA repair complex, protein binding, protein binding, molecular adaptor activity, positive regulation of double-strand break repair via nonhomologous end joining, protein localization to site of double-strand break, double-strand break repair via nonhomologous end joining, damaged DNA binding, cellular response to DNA damage stimulus
Domain/feature annotations: Modulator of retrovirus infection
Sequence:
METLKSKTKTRVLPSWMTAPVDERKVVSVKTATRKQTAAWAQRVGAATRAPATETVYCMNEAEMVDVALGILIEGRKQEKPWEQRSLEATDKLQLSPPCSSSPGSSSEEEDSRISSLAPGLSPPRGPEASDSPCSRSPEEEKEEEDALKYVREIFFS
Protein: Transient receptor potential cation channel subfamily V member 5
UniProt accession: Q9NQA5
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ECAC1, TRPV5
Length: 729 residues
Disorder content (fraction disordered): 0.1906721536351166
Curated region start positions: 587, 587, 587
Curated region end positions: 725, 725, 725
Curated region terms: disorder, disorder, protein binding
Domain/feature annotations: Ankyrin repeat-containing domain, Ankyrin repeat-containing domain, Ankyrin repeat, Ion transport protein, Ankyrin repeats (3 copies)
Sequence:
MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF
Protein: Emerin
UniProt accession: P50402
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: EDMD, EMD, STA
Length: 254 residues
Disorder content (fraction disordered): 0.5590551181102362
Curated region start positions: 46, 67, 95, 131
Curated region end positions: 187, 170, 99, 135
Curated region terms: disorder, disorder, amyloid fibril formation, amyloid fibril formation
Domain/feature annotations: 1.10.720.40, LEM domain
Cross-references: BMRB:26654
Sequence:
MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRLSPPSSSAASSYSFSDLNSTRGDADMYDLPKKEDALLYQSKGYNDDYYEESYFTTRTYGEPESAGPSRAVRQSVTSFPDADAFHHQVHDDDLLSSSEEECKDRERPMYGRDSAYQSITHYRPVSASRSSLDLSYYPTSSSTSFMSSSSSSSSWLTRRAIRPENRAPGAGLGQDRQVPLWGQLLLFLVFVIVLFFIYHFMQAEEGNPF
Protein: U1 small nuclear ribonucleoprotein A
UniProt accession: P09012
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SNRPA
Length: 282 residues
Disorder content (fraction disordered): 0.38652482269503546
Curated region start positions: 102, 102, 115, 115, 99
Curated region end positions: 117, 117, 207, 207, 117
Curated region terms: disorder, DNA binding, disorder, flexible linker, disorder
Domain/feature annotations: 3.30.70.330, 3.30.70.330, RNA recognition motif, RNA recognition motif
Cross-references: PDB:1FHT, PDB:1fht, PDB:3PGW, PMID:21113136
Sequence:
MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
Protein: Proheparin-binding EGF-like growth factor
UniProt accession: Q99075
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: DTR, DTS, HBEGF, HEGFL
Length: 208 residues
Disorder content (fraction disordered): 0.16346153846153846
Curated region start positions: 73
Curated region end positions: 106
Curated region terms: disorder
Domain/feature annotations: Laminin
Cross-references: PDB:1XDT
Sequence:
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH
Protein: Protein SMG5
UniProt accession: Q9UPR3
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: EST1B, KIAA1089, SMG5
Length: 1016 residues
Disorder content (fraction disordered): 0.022637795275590553
Curated region start positions: 924
Curated region end positions: 946
Curated region terms: disorder
Domain/feature annotations: 5'-nuclease, Est1 DNA/RNA binding domain, Telomerase activating protein Est1, PIN domain
Cross-references: PDB:2HWY
Sequence:
MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
Protein: FeS cluster assembly protein SufB
UniProt accession: P77522
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW5273, b1683, sufB, ynhE
Length: 495 residues
Disorder content (fraction disordered): 0.2222222222222222
Curated region start positions: 80, 1
Curated region end positions: 156, 33
Curated region terms: disorder, disorder
Domain/feature annotations: SUF system FeS cluster assembly, SufBD core domain, SufBD protein N-terminal region
Cross-references: PDB:5AWF
Sequence:
MSRNTEATDDVKTWTGGPLNYKEGFFTQLATDELAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHWLKAHYDKLNYQDYSYYSAPSCGNCDDTCASEPGAVQQTGANAFLSKEVEAAFEQLGVPVREGKEVAVDAIFDSVSVATTYREKLAEQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPVRDSYQLHAAVVEVIIHKNAEVKYSTVQNWFPGDNNTGGILNFVTKRALCEGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG
Protein: ATP-dependent DNA helicase Saci_0192
UniProt accession: Q4JC68
Organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomy: Archaea, Crenarchaeota, Thermoprotei, Sulfolobales, Sulfolobaceae, Sulfolobus
Gene names: Saci_0192
Length: 551 residues
Disorder content (fraction disordered): 0.08166969147005444
Curated region start positions: 99, 99, 99
Curated region end positions: 143, 143, 143
Curated region terms: disorder, disorder to order, metal ion binding
Domain/feature annotations: P-loop containing nucleotide triphosphate hydrolases, 1.10.275.30, P-loop containing nucleotide triphosphate hydrolases, DEAD_2, Helicase C-terminal domain
Cross-references: PDB:3CRW
Sequence:
MLKLRDWQEKLKDKVIEGLRNNFLVALNAPTGSGKTLFSLLVSLEVKPKVLFVVRTHNEFYPIYRDLTKIREKRNITFSFLVGKPSSCLYAEKGAESEDIPCKYCELKGSIVEVKTDDSPLSLVKKLKKDGLQDKFCPYYSLLNSLYKADVIALTYPYFFIDRYREFIDIDLREYMIVIDEAHNLDKVNELEERSLSEITIQMAIKQSKSEESRRILSKLLNQLREVVLPDEKYIKVENVPKLSKEELEILADDYEDIRKDSLKQGKVNKIHIGSILRFFSLLSIGSFIPFSYSKRLVIKNPEISYYLNLLNDNELSIILMSGTLPPREYMEKVWGIKRNMLYLDVEREIQKRVSGSYECYIGVDVTSKYDMRSDNMWKRYADYLLKIYFQAKANVLVVFPSYEIMDRVMSRISLPKYVESEDSSVEDLYSAISANNKVLIGSVGKGKLAEGIELRNNDRSLISDVVIVGIPYPPPDDYLKILAQRVSLKMNRENEEFLFKIPALVTIKQAIGRAIRDVNDKCNVWLLDKRFESLYWKKNLKCLNANKMKL
Protein: 50S ribosomal protein L4
UniProt accession: P38516
Organism: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomy: Bacteria, Thermotogae, Thermotogales, Thermotogaceae, Thermotoga
Gene names: TM_1499, rplD
Length: 235 residues
Disorder content (fraction disordered): 0.225531914893617
Curated region start positions: 43, 43
Curated region end positions: 95, 95
Curated region terms: disorder, DNA binding
Domain/feature annotations: 3.40.1370.10, Ribosomal protein L4/L1 family
Cross-references: PDB:1DMG
Sequence:
MAQVDLLNVKGEKVGTLEISDFVFNIDPNYDVMWRYVDMQLSNRRAGTASTKTRGEVSGGGRKPWPQKHTGRARHGSIRSPIWRHGGVVHGPKPRDWSKKLNKKMKKLALRSALSVKYRENKLLVLDDLKLERPKTKSLKEILQNLQLSDKKTLIVLPWKEEGYMNVKLSGRNLPDVKVIIADNPNNSKNGEKAVRIDGLNVFDMLKYDYLVLTRDMVSKIEEVLGNEAGKALTA
Protein: Osteocalcin
UniProt accession: Q8HYY9
Organism: Sus scrofa
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Laurasiatheria, Artiodactyla, Suina, Suidae, Sus
Gene names: BGLAP
Length: 49 residues
Disorder content (fraction disordered): 0.24489795918367344
Dataset labels: Extracellular matrix proteins
Curated region start positions: 1
Curated region end positions: 12
Curated region terms: disorder
Domain/feature annotations: Osteocalcin, C-terminal domain
Cross-references: PDB:1Q8H
Sequence:
YLDHGLGAPAPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGIA
Protein: Peroxiredoxin-4
UniProt accession: O08807
Organism: Mus musculus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Mus, Mus
Gene names: Prdx4
Length: 274 residues
Disorder content (fraction disordered): 0.11313868613138686
Curated region start positions: 256, 244, 244, 244, 252, 246
Curated region end positions: 274, 263, 263, 263, 263, 251
Curated region terms: disorder, disorder, protein binding, disorder to order, disorder, protein binding
Domain/feature annotations: Glutaredoxin, AhpC/TSA family, C-terminal domain of 1-Cys peroxiredoxin
Cross-references: PDB:3VWU, PDB:3W8J
Sequence:
MEARSKLLDGTTASRRWTRKLVLLLPPLLLFLLRTESLQGLESDERFRTRENECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN
Protein: Cell death protein 4
UniProt accession: P30429-1
Organism: Caenorhabditis elegans
Taxonomy: Eukaryota, Metazoa, Ecdysozoa, Nematoda, Chromadorea, Rhabditida, Rhabditina, Rhabditomorpha, Rhabditoidea, Rhabditidae, Peloderinae, Caenorhabditis
Gene names: C35D10.9, ced-4
Length: 571 residues
Disorder content (fraction disordered): 0.18914185639229425
Curated region start positions: 1
Curated region end positions: 108
Curated region terms: disorder
Domain/feature annotations: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain, Death Domain, Fas, P-loop containing nucleotide triphosphate hydrolases, Ced-4 linker helical domain-like
Cross-references: PDB:2A5Y
Sequence:
MLCEIECRALSTAHTRLIHDFEPRDALTYLEGKNIFTEDHSELISKMSTRLERIANFLRIYRRQASELGPLIDFFNYNNQSHLADFLEDYIDFAINEPDLLRPVVIAPQFSRQMLDRKLLLGNVPKQMTCYIREYHVDRVIKKLDEMCDLDSFFLFLHGRAGSGKSVIASQALSKSDQLIGINYDSIVWLKDSGTAPKSTFDLFTDILLMLARVVSDTDDSHSITDFINRVLSRSEDDLLNFPSVEHVTSVVLKRMICNALIDRPNTLFVFDDVVQEETIRWAQELRLRCLVTTRDVEISNAASQTCEFIEVTSLEIDECYDFLEAYGMPMPVGEKEEDVLNKTIELSSGNPATLMMFFKSCEPKTFEKMAQLNNKLESRGLVGVECITPYSYKSLAMALQRCVEVLSDEDRSALAFAVVMPPGVDIPVKLWSCVIPVDICSNEEEQLDDEVADRLKRLSKRGALLSGKRMPVLTFKIDHIIHMFLKHVVDAQTIANGISILEQRLLEIGNNNVSVPERHIPSHFQKFRRSSASEMYPKTTEETVIRPEDFPKFMQLHQKFYDSLKNFACC
Protein: Origin recognition complex subunit 1
UniProt accession: Q13415
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: ORC1, ORC1L, PARC1
Length: 861 residues
Disorder content (fraction disordered): 0.036004645760743324
Dataset labels: NDDs-related proteins
Curated region start positions: 662, 471
Curated region end positions: 673, 489
Curated region terms: disorder, disorder
Domain/feature annotations: P-loop containing nucleotide triphosphate hydrolases, 2.30.30.490, ATPase family associated with various cellular activities (AAA), BAH domain, CDC6, C terminal winged helix domain, AAA lid domain
Cross-references: PDB:5UJ7, PDB:5UJM
Sequence:
MAHYPTRLKTRKTYSWVGRPLLDRKLHYQTYREMCVKTEGCSTEIHIQIGQFVLIEGDDDENPYVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYPACDSNINAETIIGLVRVIPLAPKDVVPTNLKNEKTLFVKLSWNEKKFRPLSSELFAELNKPQESAAKCQKPVRAKSKSAESPSWTPAEHVAKRIESRHSASKSRQTPTHPLTPRARKRLELGNLGNPQMSQQTSCASLDSPGRIKRKVAFSEITSPSKRSQPDKLQTLSPALKAPEKTRETGLSYTEDDKKASPEHRIILRTRIAASKTIDIREERTLTPISGGQRSSVVPSVILKPENIKKRDAKEAKAQNEATSTPHRIRRKSSVLTMNRIRQQLRFLGNSKSDQEEKEILPAAEISDSSSDEEEASTPPLPRRAPRTVSRNLRSSLKSSLHTLTKVPKKSLKPRTPRCAAPQIRSRSLAAQEPASVLEEARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTRGSPQETTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERIMMNRVSSRLGLTRMCFQPYTYSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSQQKPDSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKDE
Protein: Pre-mRNA-splicing factor 18
UniProt accession: P33411
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: PRP18, YGR006W
Length: 251 residues
Disorder content (fraction disordered): 0.0796812749003984
Curated region start positions: 198
Curated region end positions: 217
Curated region terms: disorder
Domain/feature annotations: Functional domain of the splicing factor Prp18, Prp18 domain
Cross-references: PDB:1DVK
Sequence:
MDLDLASILKGEISKKKKELANSKGVQPPCTEKFQPHESANIDETPRQVEQESTDEENLSDNQSDDIRTTISKLENRPERIQEAIAQDKTISVIIDPSQIGSTEGKPLLSMKCNLYIHEILSRWKASLEAYHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQGGRNAANIMIDERTRLWITSIKRLITFEEWYTSNHDSLA
Protein: Pre-mRNA-splicing factor cwf10
UniProt accession: O94316
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Taphrinomycotina, Schizosaccharomycetes, Schizosaccharomycetales, Schizosaccharomycetaceae, Schizosaccharomyces
Gene names: SPBC215.12, cwf10, snu114, spef2
Length: 984 residues
Disorder content (fraction disordered): 0.06097560975609756
Curated region start positions: 1
Curated region end positions: 60
Curated region terms: disorder
Domain/feature annotations: 3.30.230.10, 3.30.70.240, Yeast translation eEF2 (G' domain), Elongation Factor G (Translational Gtpase), domain 3, Translation factors, P-loop containing nucleotide triphosphate hydrolases, Elongation factor Tu GTP binding domain, Elongation factor G C-terminus, Elongation factor Tu domain 2, Elongation factor G, domain IV, 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
Sequence:
MMEEDLYDEFGNYIGPENEEDEEELFPQAPSPTIAQVPSFEEVIPDEELEDVERAEEMALSHLEPQNAVVLHEDKQYYPSAEEVYGSNVDIMVQEQDTQPLSQPIIEPIRHKRIAIETTNVPDTVYKKEFLFGLLTGTDDVRSFIVAGHLHHGKSALLDLLVYYTHPDTKPPKRRSLRYTDTHYLERERVMSIKSTPLTLAVSDMKGKTFAFQCIDTPGHVDFVDEVAAPMAISDGVVLVVDVIEGVMINTTRIIKHAILHDMPIVLVLNKVDRLILELRLPPNDAYHKLRHVIDEVNDNICQISKDLKYRVSPELGNVCFASCDLGYCFTLSSFAKLYIDRHGGIDVDLFSKRLWGDIYFDSKTRKFAKQSLDGSGVRSFVHFILEPLYKLHTLTISDEAEKLKKHLSSFQIYLKPKDYLLDPKPLLQLICASFFGFPVGFVNAVTRHIPSPRENAARKASQSYIGPINSSIGKAILEMSREESAPLVMHVTKLYNTVDANNFYAFARVYSGQVKKGQKVKVLGENYSLEDEEDMVVAHIAEICVPCARYRLHVDGAVAGMLVLLGGVDNSISKTATIVSDNLKDDPYIFRPIAHMSESVFKVAVEPHNPSELPKLLDGLRKTNKSYPLSITKVEESGEHTIFGTGEMYMDCLLYDLRTLYSEIEIRVSDPVARFCETAVDTSSIKCFSDTPNKKNRITMVVEPLEKGISNDIENGKVNINWPQKRISEFFQKNYDWDLLASRSIWAFGPDDRGTNILRDDTLSTDVDKNVLNSVKEYIKQGFQWGTREGPLCDETIRNVNFRLMDVVLAPEQIYRGGGQIIPTARRVCYSSFLTASPRLMEPVYMVEVHAPADSLPIIYDLLTRRRGHVLQDIPRPGSPLYLVRALIPVIDSCGFETDLRVHTQGQAMCQMVFDHWQVVPGDPLDKSIKPKPLEPARGSDLARDFLIKTRRRKGLVEDVSTTRYFDQEMIDSLKEAGVVLSL
Protein: Choline-phosphate cytidylyltransferase A
UniProt accession: P19836
Organism: Rattus norvegicus
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Glires, Rodentia, Myomorpha, Muroidea, Muridae, Murinae, Rattus
Gene names: Ctpct, Pcyt1, Pcyt1a
Length: 367 residues
Disorder content (fraction disordered): 0.5994550408719346
Curated region start positions: 1, 1, 217, 237, 294, 311, 313, 237, 237, 238, 238, 271, 275, 312, 312, 36, 36, 36, 237
Curated region end positions: 39, 15, 236, 293, 312, 367, 367, 293, 293, 299, 299, 293, 295, 367, 367, 69, 69, 69, 293
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, phosphorylation display site, order, disorder to order, choline-phosphate cytidylyltransferase activity, localization, molecular function inhibitor activity, self-assembly, disorder, phosphorylation display site, disorder, order to disorder, order, lipid binding
Domain/feature annotations: HUPs, Cytidylyltransferase-like
Cross-references: PDB:3HL4, PDB:4MVC, PDB:4MVD
Sequence:
MDAQSSAKVNSRKRRKEVPGPNGATEEDGIPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRCKAVTCDISEDEED
Protein: Regulatory protein GAL4
UniProt accession: P04386
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Taxonomy: Eukaryota, Fungi, Dikarya, Ascomycota, Saccharomycotina, Saccharomycetes, Saccharomycetales, Saccharomycetaceae, Saccharomyces
Gene names: GAL4, YPL248C
Length: 881 residues
Disorder content (fraction disordered): 0.043132803632236094
Curated region start positions: 107
Curated region end positions: 144
Curated region terms: disorder
Domain/feature annotations: Zn(2)-C6 fungal-type DNA-binding domain, 1.20.5.170, Fungal Zn(2)-Cys(6) binuclear cluster domain, Gal4-like dimerisation domain, Fungal specific transcription factor domain
Sequence:
MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSIDSAAHHDNSTIPLDFMPRDALHGFDWSEEDDMSDGLPFLKTDPNNNGFFGDGSLLCILRSIGFKPENYTNSNVNRLPTMITDRYTLASRSTTSRLLQSYLNNFHPYCPIVHSPTLMMLYNNQIEIASKDQWQILFNCILAIGAWCIEGESTDIDVFYYQNAKSHLTSKVFESGSIILVTALHLLSRYTQWRQKTNTSYNFHSFSIRMAISLGLNRDLPSSFSDSSILEQRRRIWWSVYSWEIQLSLLYGRSIQLSQNTISFPSSVDDVQRTTTGPTIYHGIIETARLLQVFTKIYELDKTVTAEKSPICAKKCLMICNEIEEVSRQAPKFLQMDISTTALTNLLKEHPWLSFTRFELKWKQLSLIIYVLRDFFTNFTQKKSQLEQDQNDHQSYEVKRCSIMLSDAAQRTVMSVSSYMDNHNVTPYFAWNCSYYLFNAVLVPIKTLLSNSKSNAENNETAQLLQQINTVLMLLKKLATFKIQTCEKYIQVLEEVCAPFLLSQCAIPLPHISYNNSNGSAIKNIVGSATIAQYPTLPEENVNNISVKYVSPGSVGPSPVPLKSGASFSDLVKLLSNRPPSRNSPVTIPRSTPSHRSVTPFLGQQQQLQSLVPLTPSALFGGANFNQSGNIADSSLSFTFTNSSNGPNLITTQTNSQALSQPIASSNVHDNFMNNEITASKIDDGNNSKPLSPGWTDQTAYNAFGITTGMFNTTTMDDVYNYLFDDEDTPPNPKKE