Protein: Gag-Pol polyprotein
UniProt accession: P12497
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate NY5)
Taxonomy: Viruses, Riboviria, Pararnavirae, Artverviricota, Revtraviricetes, Ortervirales, Retroviridae, Orthoretrovirinae, Lentivirus
Gene names: gag-pol
Length: 1435 residues
Disorder content (fraction disordered): 0.14146341463414633
Dataset labels: Viral proteins, RNA-binding proteins
Curated region start positions: 354, 351, 108, 108, 123, 123, 217, 133, 352, 1288, 1193, 1286, 8, 44, 44, 115, 8, 8, 8, 8, 8, 8, 8
Curated region end positions: 363, 377, 143, 143, 143, 143, 231, 143, 377, 1300, 1202, 1295, 31, 114, 132, 132, 43, 43, 43, 43, 43, 43, 43
Curated region terms: disorder, disorder, disorder, flexible linker, flexible linker, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, order to disorder, disorder, disorder, disorder, disorder to order, disorder, disorder to order, protein binding, protein binding, protein binding
Domain/feature annotations: Ribonuclease H-like superfamily/Ribonuclease H, Immunodeficiency lentiviruses, gag gene matrix protein p17, Integrase, C-terminal domain superfamily, retroviral, Human Immunodeficiency Virus Type 1 Capsid Protein, 1.10.1200.30, Ribonuclease H-like superfamily/Ribonuclease H, 1.10.10.200, Acid Proteases, HIV Type 1 Reverse Transcriptase, subunit A, domain 1, 3.30.70.270, 3.30.70.270, Single helix bin, Zinc finger, CCHC-type, 3.30.70.270, RNase H, Retroviral aspartyl protease, Reverse transcriptase (RNA-dependent DNA polymerase), Zinc knuckle, Zinc knuckle, gag gene protein p17 (matrix protein), Integrase DNA binding domain, Integrase core domain, Integrase Zinc binding domain, Reverse transcriptase connection domain, Reverse transcriptase thumb domain, Gag protein p24 C-terminal domain
Cross-references: BMRB:19604, BMRB:5316, PDB:1A43, PDB:1BAJ, PDB:1GWP, PDB:1ITG, PDB:1L6N, PDB:2GOL, PDB:2GON, PDB:2JYG, PDB:2JYL, PDB:2MGU, PDB:6VRG
Sequence:
MGARASVLSGGELDKWEKIRLRPGGKKQYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTIAVLYCVHQRIDVKDTKEALDKIEEEQNKSKKKAQQAAADTGNNSQVSQNYPIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPGATLEEMMTACQGVGGPGHKARVLAEAMSQVTNPATIMIQKGNFRNQRKTVKCFNCGKEGHIAKNCRAPRKKGCWKCGKEGHQMKDCTERQANFLREDLAFPQGKAREFSSEQTRANSPTRRELQVWGRDNNSLSEAGADRQGTVSFSFPQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDGLVSAGIRKVLFLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED