LiteFold/DisProt huggingface dataset:
Protein: 40S ribosomal protein SA
UniProt accession: A4IDS4
Organism: Leishmania infantum
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: LinJ36.5570, LinJ36.5680, LinJ_36_5240, LinJ_36_5350
Length: 246 residues
Disorder content (fraction disordered): 0.14227642276422764
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 212
Curated region end positions: 246
Curated region terms: disorder
Domain/feature annotations: Ribosomal protein S2
Cross-references: EMDB:7024, PDB:6AZ1
Sequence:
MTAVESGSKVLRMKESDAQKLLAMRCHIGTRNQSSAMKKYIYGRTAEGSHIIDLHMMWEKLILAARVIAAVENPKDVCVCSSRLYGTRAIYKFSQHVGTSFHGGRFIPGTFTNQIQKKFVQPRVLVVTDPRTDHQAIREASLVNIPVIALCDTDAPLEYVDIAIPCNNRGIKSIGMMYWLLAREVLRLRGTIVRSVPWEEKVDLFFYRDPNEAAEEKAAAAAAAPAAEAEEGFGWVERNDDNAWEA
Protein: Nonstructural protein 5
UniProt accession: B6VDJ7
Organism: Dengue virus 3
Taxonomy: Viruses, Riboviria, Orthornavirae, Kitrinoviricota, Flasuviricetes, Amarillovirales, Flaviviridae, Flavivirus
Length: 85 residues
Disorder content (fraction disordered): 0.18823529411764703
Dataset labels: Neglected tropical diseases proteins, Viral proteins
Curated region start positions: 50
Curated region end positions: 65
Curated region terms: disorder
Domain/feature annotations: Flavivirus RNA-directed RNA polymerase, thumb domain
Cross-references: PDB:5FC8
Sequence:
VWIEDNPWMEDKTPVTTWENVPYLGKREDQWCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYMPSMKRFRKEEESEGAIW
Protein: Protein argonaute-1
UniProt accession: Q9UL18
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: AGO1, EIF2C1
Length: 857 residues
Disorder content (fraction disordered): 0.059509918319719954
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 1, 113, 819
Curated region end positions: 21, 126, 834
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: PAZ domain, Piwi domain, Argonaute linker 1 domain, N-terminal domain of argonaute, Mid domain of argonaute, Argonaute linker 2 domain
Cross-references: PDB:4KXT
Sequence:
MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA
Protein: Galactose-1-phosphate uridylyltransferase
UniProt accession: P07902
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GALT
Length: 379 residues
Disorder content (fraction disordered): 0.12928759894459102
Dataset labels: NDDs-related proteins
Curated region start positions: 1, 49, 367
Curated region end positions: 21, 63, 379
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Galactose-1-phosphate uridyl transferase, N-terminal domain, Galactose-1-phosphate uridyl transferase, C-terminal domain
Cross-references: PDB:5IN3
Sequence:
MSRSGTDPQQRQQASEADAAAATFRANDHQHIRYNPLQDEWVLVSAHRMKRPWQGQVEPQLLKTVPRHDPLNPLCPGAIRANGEVNPQYDSTFLFDNDFPALQPDAPSPGPSDHPLFQAKSARGVCKVMCFHPWSDVTLPLMSVPEIRAVVDAWASVTEELGAQYPWVQIFENKGAMMGCSNPHPHCQVWASSFLPDIAQREERSQQAYKSQHGEPLLMEYSRQELLRKERLVLTSEHWLVLVPFWATWPYQTLLLPRRHVRRLPELTPAERDDLASIMKKLLTKYDNLFETSFPYSMGWHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRALPEVHYHLGQKDRETATIA
Protein: Major curlin subunit
UniProt accession: P28307
Organism: Escherichia coli (strain K12)
Taxonomy: Bacteria, Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, Escherichia
Gene names: JW1025, b1042, csgA
Length: 151 residues
Disorder content (fraction disordered): 1
Dataset labels: Extracellular matrix proteins, Condensates-related proteins
Curated region start positions: 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 43, 43, 88, 88, 133, 133, 66, 111, 1
Curated region end positions: 151, 151, 151, 151, 151, 151, 151, 151, 22, 151, 65, 65, 110, 110, 151, 151, 87, 132, 151
Curated region terms: disorder, amyloid fibril formation, disorder to order, disorder, amyloid fibril formation, disorder, disorder to order, disorder, protein binding, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, amyloid fibril formation, regulation of amyloid fibril formation
Domain/feature annotations: Curlin associated repeat, Curlin associated repeat
Cross-references: AmyPro:AP00036
Sequence:
MKLLKVAAIAAIVFSGSALAGVVPQYGGGGNHGGGGNNSGPNSELNIYQYGGGNSALALQTDARNSDLTITQHGGGNGADVGQGSDDSSIDLTQRGFGNSATLDQWNGKNSEMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAHQY
Protein: Mitogen-activated protein kinase kinase kinase 7
UniProt accession: O43318
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MAP3K7, TAK1
Length: 606 residues
Disorder content (fraction disordered): 0.0462046204620462
Dataset labels: NDDs-related proteins
Curated region start positions: 66, 178
Curated region end positions: 80, 190
Curated region terms: disorder, disorder
Domain/feature annotations: Protein tyrosine and serine/threonine kinase
Cross-references: PDB:5E7R, PDB:5J7S, PDB:5J8I, PDB:5J9I, PDB:5JH6, PDB:5JK3
Sequence:
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
Protein: Multiple PDZ domain protein
UniProt accession: O75970
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MPDZ, MUPP1
Length: 2070 residues
Disorder content (fraction disordered): 0.006280193236714976
Dataset labels: NDDs-related proteins
Curated region start positions: 1171
Curated region end positions: 1183
Curated region terms: disorder
Domain/feature annotations: PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, PDZ domain, L27_2, Unstructured region 10 on multiple PDZ protein
Cross-references: PDB:2FCF
Sequence:
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS
Protein: Methionine synthase reductase
UniProt accession: Q9UBK8
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MTRR
Length: 698 residues
Disorder content (fraction disordered): 0.11461318051575932
Dataset labels: NDDs-related proteins
Curated region start positions: 165, 258, 502
Curated region end positions: 216, 271, 515
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Oxidoreductase NAD-binding domain, Flavodoxin, FAD binding domain
Cross-references: PDB:2QTL, PDB:2QTZ
Sequence:
MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS
Protein: Asparagine--tRNA ligase, cytoplasmic
UniProt accession: O43776
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NARS, NARS1, NRS
Length: 548 residues
Disorder content (fraction disordered): 0.023722627737226276
Dataset labels: NDDs-related proteins, RNA-binding proteins
Curated region start positions: 98
Curated region end positions: 110
Curated region terms: disorder
Domain/feature annotations: tRNA synthetases class II (D, K and N), OB-fold nucleic acid binding domain, Asparaginal-tRNA synthetase, N-terminal domain
Cross-references: PDB:5XIX
Sequence:
MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWNVISKSQLKNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGALEGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVAVYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCDVVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYPRFVQRCTP
Protein: NPC intracellular cholesterol transporter 1
UniProt accession: O15118
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: NPC1
Length: 1278 residues
Disorder content (fraction disordered): 0.12832550860719874
Dataset labels: NDDs-related proteins, Autophagy-related proteins
Curated region start positions: 605, 374, 288, 797, 1256, 289, 773, 960, 1252
Curated region end positions: 620, 383, 333, 813, 1278, 329, 803, 983, 1278
Curated region terms: disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder, disorder
Domain/feature annotations: Sterol-sensing domain of SREBP cleavage-activation, Niemann-Pick C1 N terminus, NPC1, middle luminal domain
Cross-references: PDB:5F18, PDB:5F1B, PDB:5JNX, PDB:6UOX
Sequence:
MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKSCATEERYKGTERERLLNF
Protein: Small ubiquitin-related modifier 2
UniProt accession: P61956
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: SMT3B, SMT3H2, SUMO2
Length: 95 residues
Disorder content (fraction disordered): 0.14736842105263157
Curated region start positions: 1
Curated region end positions: 14
Curated region terms: disorder
Domain/feature annotations: Ubiquitin-2 like Rad60 SUMO-like
Sequence:
MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
Protein: Phenylalanine-4-hydroxylase
UniProt accession: P00439
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: PAH
Length: 452 residues
Disorder content (fraction disordered): 0.04424778761061947
Dataset labels: NDDs-related proteins
Curated region start positions: 1
Curated region end positions: 20
Curated region terms: disorder
Domain/feature annotations: Biopterin-dependent aromatic amino acid hydroxylase, ACT domain
Cross-references: PDB:6HYC
Sequence:
MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK
Protein: Flagellar attachment zone protein 1
UniProt accession: A0A504WW14
Organism: Leishmania donovani
Taxonomy: Eukaryota, Discoba, Euglenozoa, Kinetoplastea, Metakinetoplastina, Trypanosomatida, Trypanosomatidae, Leishmaniinae, Leishmania
Gene names: CGC21_25710
Length: 1347 residues
Disorder content (fraction disordered): 0.9346696362286564
Dataset labels: Neglected tropical diseases proteins
Curated region start positions: 1
Curated region end positions: 1259
Curated region terms: disorder
Cross-references: EMDB:11796, EMDB:11821, PDB:7AIH, PDB:7AM2
Sequence:
MLARYLDPSVHPLRVGQVVAYDYLHAAKTWQWTLGTVREIKDYTAVVQQWGLHTGDIDTLRSILLKEVDTENGRMKNYHDMLAIAREKLASIRRSNEDRVSHVRGHFDKAREKVELIDEVDLRKVTAQAAPSPVAVAVLKAVWAVAKCDPTAVEFYEWADVQLEYRKPAALDEIAKTDVLAKLYPSAESLQQSLEQDPKLNYKAAARDSPVVASLHAWVITALAYQQAYNLLAHDKRIQEQNDAIAAAIAGMKACRAKIAKLKDELSSKDTAALPGQVTSFTRTSVLVTIPLSAVISPVNVDTDVKRCVLTKDEVEQIPIDAKITRYAQKQKLAITGSHLLDQYAAATTTHIYVTELEDRLFFFQHYMASALRDAQTAAVDAHQRLAVSLHELEAFRQKRHDAKKARAAEPELADADGVEPSSGPTSSRSPTGRAAPRGQSAAPRGTASQQHKLLGPAYQSIDPATIANEPLYAVTIEEYKAKDAAGERAMDEAERMADEVQRLAVELEDAKAAADKLAEELAAKDEELAAHRQKRHDAQQARASDPALAAADAVAPRSGKGAASPHVGAVQRQAVDPATVPVAPAVIAEEPLYVATAEELQHVRDFADQLAEELEAFRQKRHDAKKARAAEPELADADGVEPSSGPTSSRSPTGRAAPRGQSAAPRGTASQQHKLLGPAYQSIDPATIANEPLYAVTIEEYKAKDAAGERAMDEAERMADEVQRLAVELEDAKAAADKLAEELAAKDEELAAHRQKRHDAQQARASDPALAAADAVAPRSGKGAASPHVGAVQRQAVDPATVPVAPAVIAEEPLYVATAEELQHVRDFADQLAEELEAFRQKRHDAKKARAAEPELADADGVEPSSGPTSSRSPTGRAAPRGQSAAPRGTASQQHKLLGPAYQSIDPATIANEPLYAVTIEEYKAKDAAGERAMDEAERMADEVQRLAVELEDAKAAADKLAEELAAKDEELAAHRQKRHDAQQARASDPALAAADAVAPRSGKGAASPHVGAVQRQAVDPATVPVAPAVIAEEPLYVATAEELQHVRDFADQAAHDAATREAEVAGTVENLRNELDDVREMNAKLEDEVFALKEQLSDAEDAYKKLAGALVVAEDERQELCDDLEAALDELEQKKDEYDELLGNLEEVQGLLEAADVAGRTAVEALEQRNRDMADLQGELANALDASKENENLRALLDAKEREIDRLKEYNSFWTDTVGTGKQKVTHRLTKIFDGDWTRLMRHRPEALKAAFVIDSSNACHVPGDQIFLVSNSFTRRLLTRTDHCPKCDRLSTFRFMSVSGMVGRMPYKPVDTPGPSYATLYWRKQRSGKIASQPLNEVCNKNEF
Protein: Protein Mdm4
UniProt accession: O15151
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: MDM4, MDMX
Length: 490 residues
Disorder content (fraction disordered): 0.24489795918367344
Dataset labels: Cancer-related proteins
Curated region start positions: 181, 181, 181
Curated region end positions: 300, 300, 300
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: Zn-finger in Ran binding protein and others, Zinc finger, C3HC4 type (RING finger)
Cross-references: BMRB:51090
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
Protein: Vicilin
UniProt accession: B0JEU3
Organism: Solanum lycopersicum
Taxonomy: Eukaryota, Viridiplantae, Streptophyta, Embryophyta, Tracheophyta, Spermatophyta, Magnoliopsida, eudicotyledons, Gunneridae, Pentapetalae, asterids, lamiids, Solanales, Solanaceae, Solanoideae, Solaneae, Solanum, Solanum subgen. Lycopersicon
Gene names: vicilin
Length: 569 residues
Disorder content (fraction disordered): 0.1054481546572935
Curated region start positions: 418, 543
Curated region end positions: 450, 569
Curated region terms: disorder, disorder
Domain/feature annotations: Cupin, Cupin, Vicilin N terminal region
Cross-references: PDB:6L4M
Sequence:
MAIFTKPKLLFIFFLILSLVLVSQCYDQNPRGYQDPQEKLRECQQRCERQQPGQQKQLCKQRCEQQYRKEQQQQHGGETGEDDLGNRGPDKSYKRLQECQRRCQSEQQGQRLQECQQRCQQEYQREKGQHQGETNPQWEQQEKSNNPYLFESQRFRSRFRASHGDFRILERFNQRSQLLKGIEKYRVAILELEPQSFVLPHHCDGEAIYVVVKGQGVINIAEQDNKNSFNLQKGDVIRLFAGSNVYLLNKDNNEKLFVYVLAKSVNAPGNLQEYFSAGGQNPESFYRAFSSDILESAFNNPRDKLERLFGQHKEGIIIKASEEQIRAISEHASRSTQQTRGRTQGPFNLMKERPVFESRFGQFFEARPERYEQLRDLDAAVGFMNINQGGMVLPYYNTKSTKLVMVIEGNARFEMACPHLGRQSQSPWSRGQGREQEREQEQEQEEGDVHYQKIRGNLNVGDVLVIPAGHPITFVATGNSNLRIVGFGVDAENNKKNFLAGKQNIWRNIDREAKELSFSMPGREVEEIFQRQDQSYFVAGPEHRQQRERGEEGRRGQDQYLSSILDFVF
Protein: Glutamate receptor ionotropic, NMDA 2B
UniProt accession: Q13224
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: GRIN2B, NMDAR2B
Length: 1484 residues
Disorder content (fraction disordered): 0.05053908355795148
Dataset labels: NDDs-related proteins, Age-related disorders proteins
Curated region start positions: 1, 201, 393, 580
Curated region end positions: 33, 212, 402, 599
Curated region terms: disorder, disorder, disorder, disorder
Domain/feature annotations: Ligand-gated ion channel, Receptor family ligand binding region, N-methyl D-aspartate receptor 2B3 C-terminus, Ligated ion channel L-glutamate- and glycine-binding site
Cross-references: EMDB:EMD-31309, PDB:7EU8
Sequence:
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
Protein: AMP deaminase 2
UniProt accession: Q01433
Organism: Homo sapiens
Taxonomy: Eukaryota, Metazoa, Chordata, Craniata, Vertebrata, Euteleostomi, Mammalia, Eutheria, Euarchontoglires, Primates, Haplorrhini, Catarrhini, Hominidae, Homo
Gene names: AMPD2
Length: 825 residues
Disorder content (fraction disordered): 0.08848484848484849
Dataset labels: NDDs-related proteins
Curated region start positions: 229, 390, 228
Curated region end positions: 248, 441, 248
Curated region terms: disorder, disorder, disorder
Domain/feature annotations: AMP deaminase
Cross-references: PDB:8HU6, PDB:8HUB
Sequence:
MASYPSGSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLDLRTSMDGKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPPALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ