Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma
Year: 2025
Type: article
Language: en
Topic: Cancer, Lipids, and Metabolism
Authors and affiliations:
raw_author_name: Yunzhan Li
raw_affiliation_strings: Department of Cell and Biological Systems, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Zekun Li
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Qin Li
raw_affiliation_strings: Department of Cell and Biological Systems, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Dongxiao Sun
raw_affiliation_strings: Department of Neuroscience Experimental Therapeutics, Mass Spectrometry Core Facilities, Penn State College of Medicine, Hershey, PA, USA
Mass Spectrometry Core Facilities, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Bo Ni
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Mingjun Tan
raw_affiliation_strings: Department of Cell and Biological Systems, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Ashley E. Shay
raw_affiliation_strings: Metabolomics Core Facility, The Pennsylvania State University, University Park, PA, USA
The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA
raw_author_name: Min Wang
raw_affiliation_strings: Department of Cell and Biological Systems, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Chenyang Meng
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Guangcong Shen
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Boyang Fu
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Yueying Shan
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Shiqi Zhang
raw_affiliation_strings: The Center for Precision Medicine, Division of Nephrology, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA
raw_author_name: Rifah Rownak Tanshee
raw_affiliation_strings: Department of Cell and Biological Systems, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Tianxing Zhou
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Yongjie Xie
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
raw_author_name: Kun-Ming Chen
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA, USA
Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Bin Qiao
raw_affiliation_strings: School of Chemical Engineering, Tianjin University, Tianjin, China
raw_author_name: Yunkun Dang
raw_affiliation_strings: Center for Life Science, School of Life Sciences, Yunnan University, Kunming, China
raw_author_name: Scot R. Kimball
raw_affiliation_strings: Department of Cell and Biological Systems, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA
raw_author_name: Guanshi Zhang
raw_affiliation_strings: The Center for Precision Medicine, Division of Nephrology, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA
raw_author_name: Girish H. Rajacharya
raw_affiliation_strings: Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
raw_author_name: Pankaj K. Singh
raw_affiliation_strings: Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
raw_author_name: Xiuchao Wang
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. wangxiuchao@tjmuch.com
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. wangxiuchao@tjmuch.com
raw_author_name: Jihui Hao
raw_affiliation_strings: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. haojihui@tjmuch.com
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. haojihui@tjmuch.com
raw_author_name: Shengyu Yang
raw_affiliation_strings: Department of Cell and Biological Systems, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA. sxy99@psu.edu
Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA. sxy99@psu.edu