cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions
Year: 2025
Type: article
Language: en
Topic: Genetic Associations and Epidemiology
Authors and affiliations:
raw_author_name: Eric Van Buren
raw_affiliation_strings: Department of Biostatistics, Harvard T.H. Chan School of Public Health, Cambridge, MA, USA
raw_author_name: Yi Zhang
raw_affiliation_strings: Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA
Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA
Duke Cancer Institute, Durham, NC, USA
raw_author_name: Xihao Li
raw_affiliation_strings: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
raw_author_name: Margaret Sunitha Selvaraj
raw_affiliation_strings: Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
raw_author_name: Zilin Li
raw_affiliation_strings: School of Mathematics and Statistics, Northeast Normal University, Changchun, China
raw_author_name: Hufeng Zhou
raw_affiliation_strings: Department of Biostatistics, Harvard T.H. Chan School of Public Health, Cambridge, MA, USA
raw_author_name: Nicholette D. Palmer
raw_affiliation_strings: Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA
raw_author_name: Donna K. Arnett
raw_affiliation_strings: Provost Office, University of South Carolina, Columbia, SC, USA
raw_author_name: John Blangero
raw_affiliation_strings: Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA
raw_author_name: Eric Boerwinkle
raw_affiliation_strings: Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
raw_author_name: Brian E. Cade
raw_affiliation_strings: Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
raw_author_name: Jenna C. Carlson
raw_affiliation_strings: Department of Human Genetics and Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA
raw_author_name: April P. Carson
raw_affiliation_strings: Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
raw_author_name: Yii-Der Ida Chen
raw_affiliation_strings: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA
raw_author_name: Joanne Curran
raw_affiliation_strings: Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA
raw_author_name: Ravindranath Duggirala
raw_affiliation_strings: Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA
raw_author_name: Myriam Fornage
raw_affiliation_strings: Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA
raw_author_name: Nora Franceschini
raw_affiliation_strings: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
raw_author_name: Misa Graff
raw_affiliation_strings: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
raw_author_name: Charles Gu
raw_affiliation_strings: Division of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA
raw_author_name: Xiuqing Guo
raw_affiliation_strings: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA
raw_author_name: Jiang He
raw_affiliation_strings: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
raw_author_name: Nancy Heard-Cosa
raw_affiliation_strings: Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA
Framingham Heart Study, Framingham, MA, USA
raw_author_name: Lifang Hou
raw_affiliation_strings: Department of Preventive Medicine, Northwestern University, Chicago, IL, USA
raw_author_name: Yi-Jen Hung
raw_affiliation_strings: Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
raw_author_name: Rita R. Kalyani
raw_affiliation_strings: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
raw_author_name: Sharon L. R. Kardia
raw_affiliation_strings: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Eimear Kenny
raw_affiliation_strings: Center for Translational Genomics, Icahn School of Medicine, New York, NY, USA
Departments of Genetics and Genomic Sciences, Icahn School of Medicine, New York, NY, USA
Division of Genomic Medicine, Department of Medicine, Icahn School of Medicine, New York, NY, USA
Institute for Genomic Health, Icahn School of Medicine, New York, NY, USA
raw_author_name: Charles Kooperberg
raw_affiliation_strings: Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA
raw_author_name: Brian G. Kral
raw_affiliation_strings: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
raw_author_name: Leslie Lange
raw_affiliation_strings: Department of Biomedical Informatics, University of Colorado, School of Medicine, Aurora, CO, USA
raw_author_name: Dan Levy
raw_affiliation_strings: Framingham Heart Study, Framingham, MA, USA
raw_author_name: Changwei Li
raw_affiliation_strings: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
Tulane University Translational Science Institute, New Orleans, LA, USA
raw_author_name: Simin Liu
raw_affiliation_strings: Department of Epidemiology, Brown University, Providence, RI, USA
raw_author_name: Donald Lloyd-Jones
raw_affiliation_strings: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
raw_author_name: Ruth J. F. Loos
raw_affiliation_strings: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
raw_author_name: Ani W. Manichaikul
raw_affiliation_strings: Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA
raw_author_name: Lisa Warsinger Martin
raw_affiliation_strings: George Washington University School of Medicine and Health Sciences, Washington, DC, USA
raw_author_name: Rasika Mathias
raw_affiliation_strings: Laboratory of Allergic Diseases, Genomics and Precision Health Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
raw_author_name: Ryan L. Minster
raw_affiliation_strings: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
raw_author_name: Braxton D. Mitchell
raw_affiliation_strings: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
raw_author_name: Josyf C. Mychaleckyj
raw_affiliation_strings: Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA
raw_author_name: Take Naseri
raw_affiliation_strings: International Health Institute, Brown University, Providence, RI, USA
Naseri & Associates Public Health Consultancy Firm and Public Health Clinic, Apia, Samoa
raw_author_name: Kari North
raw_affiliation_strings: Border Health Research Center, UTHealth Houston School of Public Health-Brownsville Campus, Brownsville, TX, USA
Department of Epidemiology, UTHealth Houston School of Public Health-Brownsville Campus, Brownsville, TX, USA
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Department of Internal Medicine, McGovern Medical School, Houston, TX, USA
raw_author_name: Jeff O’Connell
raw_author_name: James A. Perry
raw_affiliation_strings: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
raw_author_name: Patricia A. Peyser
raw_affiliation_strings: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Bruce M. Psaty
raw_affiliation_strings: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
Department of Epidemiology, University of Washington, Seattle, WA, USA
Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA
raw_author_name: Laura M. Raffield
raw_affiliation_strings: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
raw_author_name: Ramachandran S. Vasan
raw_affiliation_strings: Department of Quantitative and Qualitative Health Sciences, UT Health San Antonio School of Public Health, San Antonio, TX, USA
Framingham Heart Study, Framingham, MA, USA
raw_author_name: Susan Redline
raw_affiliation_strings: Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA
raw_author_name: Alex P. Reiner
raw_affiliation_strings: Department of Epidemiology, University of Washington, Seattle, WA, USA
Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA
raw_author_name: Stephen S. Rich
raw_affiliation_strings: Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA
raw_author_name: Jennifer A. Smith
raw_affiliation_strings: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Brian Spitzer
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raw_author_name: Hua Tang
raw_affiliation_strings: Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA
raw_author_name: Kent D. Taylor
raw_affiliation_strings: The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA
raw_author_name: Russell Tracy
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Larnar College of Medicine, University of Vermont, Burlington, VT, USA
raw_author_name: Satupa’itea Viali
raw_affiliation_strings: Department of Chronic Disease Epidemiology, Yale University, New Haven, CT, USA
Oceania University of Medicine, School of Medicine, National University of Samoa, Apia, Samoa
raw_author_name: Lisa Yanek
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raw_author_name: Wei Zhao
raw_affiliation_strings: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Namiko Abe
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raw_author_name: Gonçalo Abecasis
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raw_author_name: Seth Ament
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raw_author_name: Deborah Applebaum-Bowden
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raw_author_name: Stella Aslibekyan
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raw_author_name: Paul Auer
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raw_author_name: Gerald Beck
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