Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma
Year: 2025
Type: article
Language: en
Topic: Hedgehog Signaling Pathway Studies
Authors and affiliations:
raw_author_name: Anna S. Kolodziejczak
raw_affiliation_strings: CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
raw_author_name: Florian Selt
raw_affiliation_strings: CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
raw_author_name: Heike Peterziel
raw_affiliation_strings: Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
raw_author_name: Nora Jamaladdin
raw_affiliation_strings: CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Heidelberg University, 69117 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
raw_author_name: Norman Mack
raw_affiliation_strings: Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
raw_author_name: Kendra Maaß
raw_affiliation_strings: Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
raw_author_name: Chris Meulenbroeks
raw_affiliation_strings: Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands
raw_author_name: Romain Sigaud
raw_affiliation_strings: CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Comprehensive Cancer Center Central Germany (CCCG), 07743 Jena, Germany
University Hospital Jena, Department of Pediatrics and Adolescent Medicine, Friedrich Schiller University Jena, 07747 Jena, Germany
raw_author_name: Christel Herold-Mende
raw_affiliation_strings: Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Medical Faculty Heidelberg, 69120 Heidelberg, Germany
raw_author_name: Ahmed El Damaty
raw_affiliation_strings: Pediatric Neurosurgery Division, Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany
raw_author_name: Jürgen Burhenne
raw_affiliation_strings: Department of Clinical Pharmacology and Pharmacoepidemiology, Medical Faculty Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany
raw_author_name: Shunya Ohmura
raw_affiliation_strings: Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
raw_author_name: Tim Holland-Letz
raw_affiliation_strings: Department of Biostatistics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
raw_author_name: Lena M. Kutscher
raw_affiliation_strings: Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
raw_author_name: Aurélie Ernst
raw_affiliation_strings: German Cancer Consortium (DKTK), DKFZ, Core Center, 69120 Heidelberg, Germany
Group Genome Instability in Tumors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
raw_author_name: Pei-Chi Wei
raw_affiliation_strings: Brain Mosaicism and Tumorigenesis, German Cancer Research Center, 69120 Heidelberg, Germany
Heidelberg University, 69117 Heidelberg, Germany
raw_author_name: Thomas G.P. Grünewald
raw_affiliation_strings: Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
raw_author_name: Ina Oehme
raw_affiliation_strings: CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
raw_author_name: Marcel Kool
raw_affiliation_strings: Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands
University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands
raw_author_name: David T.W. Jones
raw_affiliation_strings: Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
raw_author_name: Kristian W. Pajtler
raw_affiliation_strings: Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
raw_author_name: Christian P. Kratz
raw_affiliation_strings: Paediatric Haematology and Oncology, Hannover Medical School, 30625 Hannover, Germany
raw_author_name: Stefan M. Pfister
raw_affiliation_strings: Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, 69120 Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
raw_author_name: Olaf Witt
raw_affiliation_strings: CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, 69120 Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
raw_author_name: Till Milde
raw_affiliation_strings: CCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Comprehensive Cancer Center Central Germany (CCCG), 07743 Jena, Germany
Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany
University Hospital Jena, Department of Pediatrics and Adolescent Medicine, Friedrich Schiller University Jena, 07747 Jena, Germany