Development of a SIN1 Targeting Inhibitor as a Novel Therapeutic Approach for the Treatment of Malignancies
Year: 2025
Type: article
Language: en
Topic: PI3K/AKT/mTOR signaling in cancer
Authors and affiliations:
raw_author_name: Elspeth M. Beauchamp
raw_affiliation_strings: 3Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois
Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 2 Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, , Chicago, Illinois
raw_author_name: Atul Jain
raw_affiliation_strings: Northwestern University 4 Department of Chemistry, , Evanston, Illinois
raw_author_name: Matt Clutter
raw_affiliation_strings: Northwestern University 5 High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, , Evanston, Illinois
raw_author_name: Dominik Nahotko
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Emely Lopez Fajardo
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Purav P. Vagadia
raw_affiliation_strings: Northwestern University 4 Department of Chemistry, , Evanston, Illinois
raw_author_name: Sara F. Dunne
raw_affiliation_strings: Northwestern University 5 High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, , Evanston, Illinois
raw_author_name: Alain Mina
raw_affiliation_strings: National Cancer Institute 6 Myeloid Malignancies Program, Center for Cancer Research, Immune Deficiency and Cellular Therapy Program, , Bethesda, Maryland
Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 2 Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, , Chicago, Illinois
raw_author_name: Mariafausta Fischietti
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 2 Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, , Chicago, Illinois
raw_author_name: Chidera V. Oku
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Gavin T. Blyth
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Rama K. Mishra
raw_affiliation_strings: 7Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois
raw_author_name: Elena Karras
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Sara G. Radecki
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Connor Lantz
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Sidharth Addepalli
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Mirage Modi
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Lihua Zou
raw_affiliation_strings: 7Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
raw_author_name: Byoung-Kyu Cho
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 8 Proteomics Center of Excellence, , Evanston, Illinois
raw_author_name: Young Ah Goo
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 8 Proteomics Center of Excellence, , Evanston, Illinois
raw_author_name: Jenna Rossoff
raw_affiliation_strings: 10Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Ann & Robert H. Lurie Children’s Hospital of Chicago 9 Division of Hematology, Oncology and Stem Cell Transplantation, , Chicago, Illinois
raw_author_name: Eleanor N. Fish
raw_affiliation_strings: 11Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
12Department of Immunology, University of Toronto, Toronto, Canada
raw_author_name: Diana Saleiro
raw_affiliation_strings: Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 2 Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, , Chicago, Illinois
raw_author_name: Gary E. Schiltz
raw_affiliation_strings: 13Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 4 Department of Chemistry, , Evanston, Illinois
raw_author_name: Leonidas C. Platanias
raw_affiliation_strings: 3Department of Medicine, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois
Northwestern University 1 Robert H. Lurie Comprehensive Cancer Center, , Chicago, Illinois
Northwestern University 2 Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, , Chicago, Illinois