Selective genome editing of amplified oncogenes triggers immunogenic cell death and tumor remodeling
Year: 2025
Type: article
Language: en
Topic: CRISPR and Genetic Engineering
Authors and affiliations:
raw_author_name: A. Nieto-Sanchez
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: M. Martinez-Lage
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: P. Puig-Serra
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: S. Carpintero
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: A. Alonso-Yanez
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: P. Ojeda-Walczuk
raw_affiliation_strings: Advanced Therapies Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain
Division of Hematopoietic Innovative Therapies, Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Ciemat), Madrid, Spain
raw_author_name: M. Ibañez-Navarro
raw_affiliation_strings: Pediatric Onco-Hematology Clinical Reseacrh Unit IdiPAZ-CNIO, Madrid, Spain
raw_author_name: G. Pita
raw_affiliation_strings: Human Genotyping Unit-CEGEN, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: FJ. Moya
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: C. Moreno
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: MC. Martin
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: R. Alonso
raw_affiliation_strings: Human Genotyping Unit-CEGEN, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: R. Nuñez-Torres
raw_affiliation_strings: Human Genotyping Unit-CEGEN, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: VJ. Sanchez-Arevalo Lobo
raw_affiliation_strings: Grupo de Oncología Cutánea. Servicio de Anatomía Patológica, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
Grupo de Oncología Molecular, Instituto de Investigaciones Biosanitarias, Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria (UFV), Madrid, Spain
raw_author_name: L. Alonso-Guirado
raw_affiliation_strings: Genetic and Molecular Epidemiology group, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), and CIBERONC, Madrid, Spain
raw_author_name: N. Malats
raw_affiliation_strings: Genetic and Molecular Epidemiology group, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), and CIBERONC, Madrid, Spain
raw_author_name: A. Gonzalez-Neira
raw_affiliation_strings: Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain
Human Genotyping Unit-CEGEN, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain
raw_author_name: L. Fernandez
raw_affiliation_strings: Pediatric Onco-Hematology Clinical Reseacrh Unit IdiPAZ-CNIO, Madrid, Spain
raw_author_name: P. Roda-Navarro
raw_affiliation_strings: Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, 12 de Octubre Health Research Institute (imas12), Madrid, Spain
raw_author_name: R. Torres-Ruiz
raw_affiliation_strings: Advanced Therapies Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain. rtorresr@cnio.es
Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain. rtorresr@cnio.es
Division of Hematopoietic Innovative Therapies, Biomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Ciemat), Madrid, Spain. rtorresr@cnio.es
Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain. rtorresr@cnio.es
raw_author_name: S. Rodriguez-Perales
raw_affiliation_strings: Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain. srodriguezp@cnio.es