Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer
Year: 2025
Type: article
Language: en
Topic: Cancer, Hypoxia, and Metabolism
Authors and affiliations:
raw_author_name: Lingzhi Zhu
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Kuishen Wu
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Jianwei You
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Wen Mi
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Jie Xu
raw_affiliation_strings: Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai 201203, China
raw_author_name: Liucheng Li
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Fang Yang
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Xinyi Xia
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Haohang Yan
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Fei Li
raw_affiliation_strings: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Frontier Innovation Center, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China. Electronic address: fuming_li@fudan.edu.cn
raw_author_name: Fei Li
raw_affiliation_strings: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Frontier Innovation Center, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China. Electronic address: fuming_li@fudan.edu.cn
raw_author_name: Li Chen
raw_affiliation_strings: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China
raw_author_name: Pingyu Liu
raw_affiliation_strings: Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai 201203, China
raw_author_name: Fuming Li
raw_affiliation_strings: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Frontier Innovation Center, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China. Electronic address: fuming_li@fudan.edu.cn
raw_author_name: Fuming Li
raw_affiliation_strings: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Frontier Innovation Center, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Drug Clinical Trial Center, Shanghai Xuhui Central Hospital, Institute of Clinical Mass Spectrometry, Shanghai Academy of Experimental Medicine, Fudan University, Shanghai 200438, China. Electronic address: fuming_li@fudan.edu.cn