Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma
Year: 2025
Type: article
Language: en
Topic: Protein Degradation and Inhibitors
Authors and affiliations:
raw_author_name: Ashley Vardon
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
Institute of Cancer and Genomic Medicine, University of Birmingham, Birmingham, UK
raw_author_name: Scott Haston
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Hiba Hamdi
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Grace Cooksley
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Romain Guiho
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
INSERM, Regenerative Medicine and Skeleton, Nantes Université, Oniris, RMeS, UMR 1229, F-44000, Nantes, France
raw_author_name: Diana Carvalho
raw_affiliation_strings: Brain Tumour Research Centre of Excellence, Division of Molecular Pathology, Institute of Cancer Research, London, UK
raw_author_name: Rebecca Carter
raw_affiliation_strings: UCL Cancer Institute, University College London, Paul O'Gorman Building, London, UK
raw_author_name: Jessica Katherine Rowena Boult
raw_affiliation_strings: Division of Radiotherapy and Imaging, Institute of Cancer Research, London, UK
raw_author_name: Daniel Gharai
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Ielyaas Cloete
raw_affiliation_strings: Department of Medical Physics and Biomedical Engineering, University College London, London, UK
raw_author_name: James Grey
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: John Apps
raw_affiliation_strings: Institute of Cancer and Genomic Medicine, University of Birmingham, Birmingham, UK
raw_author_name: Daohong Zhou
raw_affiliation_strings: Department of Biochemistry and Structural Biology and Center for Innovative Drug Discovery, University of Texas Health San Antonio, San Antonio, USA
raw_author_name: Guangrong Zheng
raw_affiliation_strings: University of Florida Health Cancer Center, University of Florida, Gainesville, USA
raw_author_name: Ramón Martínez-Máñez
raw_affiliation_strings: CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, València, Spain
raw_author_name: Mark Francis Lythgoe
raw_affiliation_strings: UCL Cancer Institute, University College London, Paul O'Gorman Building, London, UK
raw_author_name: Laura Kate Donovan
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Angel Montero Carcaboso
raw_affiliation_strings: SJD Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain
raw_author_name: Owen Williams
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Ying Hong
raw_affiliation_strings: Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Paula Alexandre
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Jesus Gil
raw_affiliation_strings: Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK
MRC Laboratory of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK
raw_author_name: Jamie Adam Dean
raw_affiliation_strings: Department of Medical Physics and Biomedical Engineering, University College London, London, UK
Physics of Living Systems, University College London, London, UK
raw_author_name: David Michod
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Chris Jones
raw_affiliation_strings: Brain Tumour Research Centre of Excellence, Division of Molecular Pathology, Institute of Cancer Research, London, UK
raw_author_name: Darren Hargrave
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK
raw_author_name: Juan-Pedro Martinez-Barbera
raw_affiliation_strings: Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK. j.martinez-barbera@ucl.ac.uk