Novel CDK2/4/6 inhibitor culmerciclib (TQB3616) plus fulvestrant in previously treated, HR-positive, HER2-negative advanced breast cancer: a randomized, double-blind, phase 3 trial
Year: 2025
Type: article
Language: en
Topic: Advanced Breast Cancer Therapies
Authors and affiliations:
raw_author_name: Yongmei Yin
raw_affiliation_strings: Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China. ym.yin@hotmail.com
raw_author_name: Qingyuan Zhang
raw_affiliation_strings: Breast Internal Medicine Ward 1, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China
raw_author_name: Tao Sun
raw_affiliation_strings: Department of Breast Internal Medicine, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
raw_author_name: Chunfang Hao
raw_affiliation_strings: Department of Breast Oncology, Tianjin Medical University Cancer Institute & Hospital/Tianjin Cancer Hospital Airport Hospital, Tianjin, China
raw_author_name: Zhihong Wang
raw_affiliation_strings: Department of Breast and Thyroid Surgery, the Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China
raw_author_name: Jin Yang
raw_affiliation_strings: Department of Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
raw_author_name: Yongsheng Wang
raw_affiliation_strings: Breast Surgery Ward One, Shandong Cancer Hospital, Jinan, Shandong, China
raw_author_name: Yanxia Shi
raw_affiliation_strings: Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
raw_author_name: Jing Sun
raw_affiliation_strings: Department of Oncology, Anyang Tumor Hospital, Anyang, Henan, China
raw_author_name: Quchang Ouyang
raw_affiliation_strings: Department of Breast Internal Medicine, Hunan Cancer Hospital, Changsha, Hunan, China
raw_author_name: Haichuan Su
raw_affiliation_strings: Department of Oncology, the Second Affiliated Hospital of Chinese PLA Air Force Medical University, Xi'an, Shaanxi, China
raw_author_name: Jinsheng Wu
raw_affiliation_strings: Department of Radiation Oncology, the First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China
raw_author_name: Lu Gan
raw_affiliation_strings: Department of Medical Oncology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
raw_author_name: Meng Han
raw_affiliation_strings: Department of Breast Surgery, the First hospital of Qinhuangdao, Qinhuangdao, Hebei, China
raw_author_name: Liming Gao
raw_affiliation_strings: Department of Oncology, the First hospital of Qinhuangdao, Qinhuangdao, Hebei, China
raw_author_name: Xiaojia Wang
raw_affiliation_strings: Department of Breast Oncology, the First Affiliated Hospital of Henan University of Science & Technology, Luoyang, Henan, China
Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Department of Internal Medicine-Oncology, Shao Yifu Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
raw_author_name: Bing Zhao
raw_affiliation_strings: Department of Breast Internal Medicine, Cancer Hospital of Xinjiang medical University, Urumqi, Xinjiang, China
raw_author_name: Hui Li
raw_affiliation_strings: Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, China
Department of Breast Surgery, Sichuan Cancer Hospital, Chengdu, Sichuan, China
raw_author_name: Jiuda Zhao
raw_affiliation_strings: Breast Disease Diagnosis and Treatment Center, Qinghai University Affiliated Hospital, Xining, Qinghai, China
raw_author_name: Hongwei Yang
raw_affiliation_strings: Department of Breast and Thyroid Surgery, Suining Central Hospital, Suining, Sichuan, China
raw_author_name: Fangling Ning
raw_affiliation_strings: Department of Oncology, Binzhou Medical College Affiliated Hospital, Binzhou, Shandong, China
raw_author_name: Fuguo Tian
raw_affiliation_strings: Department of Breast surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China
raw_author_name: Juliang Zhang
raw_affiliation_strings: Department of Thyroid and breast vascular surgery, The First Affiliated Hospital of Chinese PLA Air Force Medical University, Xi'an, Shaanxi, China
raw_author_name: Hongmei Sun
raw_affiliation_strings: Department of Oncology, Jiamusi Cancer Hospital, Jiamusi, Heilongjiang, China
raw_author_name: Zhaofeng Niu
raw_affiliation_strings: Department of Breast, Yuncheng Central Hospital, Yuncheng, Shanxi, China
raw_author_name: Hong Zong
raw_affiliation_strings: Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
raw_author_name: Aimin Zang
raw_affiliation_strings: Department of Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei, China
raw_author_name: Xinshuai Wang
raw_affiliation_strings: Department of Breast Oncology, the First Affiliated Hospital of Henan University of Science & Technology, Luoyang, Henan, China
Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Department of Internal Medicine-Oncology, Shao Yifu Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
raw_author_name: Xinyu Qian
raw_affiliation_strings: Department of Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, China
raw_author_name: Shikai Wu
raw_affiliation_strings: Department of Medical Oncology, Peking University First Hospital, Beijing, China
raw_author_name: Jianyun Nie
raw_affiliation_strings: Department of Breast Surgery III, Yunnan Cancer Hospital, Kunming, Yunnan, China
raw_author_name: Lijia He
raw_affiliation_strings: Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
raw_author_name: Ying Cheng
raw_affiliation_strings: Department of Oncology, Jilin Cancer Hospital, Jilin, Changchun, China
raw_author_name: Yanrong Hao
raw_affiliation_strings: Department of Oncology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
raw_author_name: Yi Zhai
raw_affiliation_strings: Department of Oncology, Zibo Central Hospital, Zibo, Shandong, China
raw_author_name: Huiping Li
raw_affiliation_strings: Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, China
Department of Breast Surgery, Sichuan Cancer Hospital, Chengdu, Sichuan, China
raw_author_name: Jingfen Wang
raw_affiliation_strings: Mammary gland, Linyi Cancer Hospital, Linyi, Shandong, China
raw_author_name: Shihong Wei
raw_affiliation_strings: Department of Radiation Oncology II, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China
raw_author_name: Man Li
raw_affiliation_strings: Department of Breast Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
raw_author_name: Yunjiang Liu
raw_affiliation_strings: Breast Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
raw_author_name: Hongqiang Guo
raw_affiliation_strings: Department of Breast lymphatic, Henan Cancer Hospital, Zhengzhou, Henan, China
raw_author_name: Qun Hu
raw_affiliation_strings: Department of Oncology, the Affiliated Hospital of Mongolia Medical University, Hohhot, Inner Mongolia, China
raw_author_name: Lina Liu
raw_affiliation_strings: Department of Breast Oncology, Nanyang Second General Hospital, Nanyang, Henan, China
Department of Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China
raw_author_name: Xinghua Han
raw_affiliation_strings: Department of Oncology, Anhui Provincial Hospital, Hefei, Anhui, China
raw_author_name: Ruizhen Luo
raw_affiliation_strings: Department of Breast Oncology, Cangzhou Hospital of Integrated TCM-WM Hebei, Cangzhou, Hebei, China
raw_author_name: Mingli Ni
raw_affiliation_strings: Department of Oncology, Luoyang Central Hospital, Luoyang, Henan, China
raw_author_name: Xianjun Tang
raw_affiliation_strings: Breast Tumor Center, Chongqing Cancer Hospital, Chongqing, China
raw_author_name: Zhenhua Zhai
raw_affiliation_strings: Department of Breast Internal Medicine, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China
raw_author_name: Meiqian Ding
raw_affiliation_strings: Department of Radiotherapy Oncology, Lu'an Hospital of Traditional Chinese Medicine, Lu'an, Anhui, China
raw_author_name: Haibo Wang
raw_affiliation_strings: Breast Disease Treatment Center, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
raw_author_name: Peng Shen
raw_affiliation_strings: Department of Oncology, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
raw_author_name: Xian Wang
raw_affiliation_strings: Department of Breast Oncology, the First Affiliated Hospital of Henan University of Science & Technology, Luoyang, Henan, China
Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Department of Internal Medicine-Oncology, Shao Yifu Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
raw_author_name: Lian Liu
raw_affiliation_strings: Department of Breast Oncology, Nanyang Second General Hospital, Nanyang, Henan, China
Department of Oncology, Qilu Hospital of Shandong University, Jinan, Shandong, China
raw_author_name: Wenyan Chen
raw_affiliation_strings: Department of Breast Oncology, the Third Hospital of Nanchang, Nanchang, Jiangxi, China
raw_author_name: Gang Liu
raw_affiliation_strings: Department of Oncology III, Mudanjiang Cancer Hospital, Mudanjiang, Heilongjiang, China
raw_author_name: Zhengwen Cai
raw_affiliation_strings: Department of Oncology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
raw_author_name: Zefei Jiang
raw_affiliation_strings: Department of Oncology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. jiangzefei@csco.org.cn