Modeling pathogenesis and progression of metabolic dysfunction-associated steatotic liver disease and therapeutic drug screening using hESC-derived mature polarized hepatocyte organoids
Year: 2025
Type: article
Language: en
Topic: Liver Disease Diagnosis and Treatment
Authors and affiliations:
raw_author_name: Changlu Qin
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
raw_author_name: Haibin Wu
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
raw_author_name: Peilin Liao
raw_affiliation_strings: Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
raw_author_name: Wenjiao Yan
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
raw_author_name: Xinyi Shi
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
raw_author_name: Jinghe Xie
raw_affiliation_strings: Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
School of Life Sciences, Zhaoqing University, Zhaoqing, 526061, China
raw_author_name: Shoupei Liu
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
raw_author_name: Sen Chen
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
raw_author_name: Xiangting Cao
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China
raw_author_name: Yongjian Zhou
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliation Hospital, School of Medicine, South China University of Technology, No.1 Panfu Road, Guangzhou, 510180, China. yongjian_zhou@outlook.com
Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China. yongjian_zhou@outlook.com
Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China
raw_author_name: Yuyou Duan
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China. yuyouduan@scut.edu.cn
Laboratory of Stem Cells and Translational Medicine, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China. yuyouduan@scut.edu.cn
Laboratory of Stem Cells and Translational Medicine, Institute for Clinical Medicine, The Second Affiliation Hospital, School of Medicine, South China University of Technology, No.1 Panfu Road, Guangzhou, 510180, China. yuyouduan@scut.edu.cn
Laboratory of Stem Cells and Translational Medicine, Institute for Life Science, School of Medicine, South China University of Technology, Guangzhou, 510006, China. yuyouduan@scut.edu.cn
National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China. yuyouduan@scut.edu.cn
The Innovation Centre of Ministry of Education for Development and Diseases, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510006, China. yuyouduan@scut.edu.cn
The Innovation Centre of Ministry of Education for Development and Diseases, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510006, China