The SEMA7AN559Y mutation facilitates the development of metabolic dysfunction-associated steatotic liver disease by inducing ROS/NLRP3-mediated hepatic cell pyroptosis
Year: 2025
Type: article
Language: en
Topic: Inflammasome and immune disorders
Authors and affiliations:
raw_author_name: Xiaoxun Zhang
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China
raw_author_name: Jiaxin Lei
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China
raw_author_name: Nan Zhao
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China
raw_author_name: Zhixian Zhu
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China
raw_author_name: Jingjing Ding
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China
raw_author_name: Qiong Pan
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China
raw_author_name: Wen-Yue Liu
raw_affiliation_strings: Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China
raw_author_name: Xiao-Zhi Jin
raw_affiliation_strings: MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, 325000, China
raw_author_name: Li-You Lian
raw_affiliation_strings: MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, 325000, China
raw_author_name: Ming-Hua Zheng
raw_affiliation_strings: MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, 325000, China. Electronic address: zhengmh@wmu.edu.cn
raw_author_name: Jin Chai
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Institute of Digestive Diseases of PLA, Third Military Medical University (Army Medical University), Chongqing, China; Cholestatic Liver Diseases Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China; Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) Medical Research Center, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China. Electronic address: jin.chai@cldcsw.org