In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association
Year: 2025
Type: article
Topic: Parkinson's Disease Mechanisms and Treatments
Authors and affiliations:
raw_author_name: Tamar Basiashvili
raw_affiliation_strings: Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093 USA
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 2085, USA
raw_author_name: Joshua Hutchings
raw_affiliation_strings: Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA
Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Department of Molecular Biology, University of California San Diego, La Jolla, CA 9093, USA
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 0815, USA
Howard Hughes Medical Institute, Chevy Chase, MD 0815, US
raw_author_name: Siyu Chen
raw_affiliation_strings: Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
Department of Molecular Biology, University of California San Diego, La Jolla, CA 9209, USA
raw_author_name: Eva P. Karasmanis
raw_affiliation_strings: Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
raw_author_name: W. Alexander Flaherty
raw_affiliation_strings: Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA
Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Howard Hughes Medical Institute, Chevy Chase, MD 2081, USA
raw_author_name: Andres E. Leschziner
raw_affiliation_strings: Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
raw_author_name: Elizabeth Villa
raw_affiliation_strings: Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA
Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA
Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 0815, USA
Department of Molecular Biology, University of California San Diego, La Jolla, CA 9093, USA
Howard Hughes Medical Institute, Chevy Chase, MD 0815, US