ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer
Year: 2025
Type: article
Language: en
Topic: Cancer, Hypoxia, and Metabolism
Authors and affiliations:
raw_author_name: Xiao Fu
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Yingyu Zhu
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Xin Lu
raw_affiliation_strings: TianJin Medical University General Hospital Medical Laboratory, Tianjin, China
raw_author_name: Xingjie Gao
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Lingbiao Xin
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Yuanyuan Ren
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Xin Liu
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Lin Ge
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Jihui Hao
raw_affiliation_strings: State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
raw_author_name: Zhi Yao
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China
raw_author_name: Lei Shi
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China. shilei@tmu.edu.cn
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China. shilei@tmu.edu.cn
raw_author_name: Jie Yang
raw_affiliation_strings: Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China. yangj@tmu.edu.cn
State Key Laboratory of Experimental Hematology, Key Laboratory of Cellular and Molecular Immunology in Tianjin, and Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University, Tianjin, China. yangj@tmu.edu.cn