Discovery and optimization of 2,3-Dihydroindole derivatives as STING receptor allosteric agonists
Year: 2025
Type: article
Language: en
Topic: interferon and immune responses
Authors and affiliations:
raw_author_name: Ying Liu
raw_affiliation_strings: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China
raw_author_name: Jing Wu
raw_affiliation_strings: Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, Shandong Province, PR China
raw_author_name: Ni Gao
raw_affiliation_strings: Department of Pediatrics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China; Shandong Luye Pharmaceutical Co., Ltd, China. Electronic address: Luxurynini@163.com
raw_author_name: Lin Zheng
raw_affiliation_strings: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China
raw_author_name: Wenbo Zhang
raw_affiliation_strings: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China
raw_author_name: Fabao Zhao
raw_affiliation_strings: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China
raw_author_name: Bairu Meng
raw_affiliation_strings: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China
raw_author_name: Xinyong Liu
raw_affiliation_strings: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China
raw_author_name: Lanyu Liu
raw_affiliation_strings: Shandong Luye Pharmaceutical Co., Ltd, China. Electronic address: liulanyu@luye.com
raw_author_name: Huajun Zhao
raw_affiliation_strings: Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, Shandong Province, PR China. Electronic address: zhaohuajun89@sdu.edu.cn
raw_author_name: Dongwei Kang
raw_affiliation_strings: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong Province, PR China. Electronic address: kangdongwei@126.com