Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure
Year: 2025
Type: article
Language: en
Topic: Cardiomyopathy and Myosin Studies
Authors and affiliations:
raw_author_name: Saffie Mohran
raw_affiliation_strings: Division of Cardiology, Medicine, University of Washington, Seattle Washington, USA; Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Center for Cardiovascular Biology, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
raw_author_name: Kristina B. Kooiker
raw_affiliation_strings: Division of Cardiology, Medicine, University of Washington, Seattle Washington, USA; Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Center for Cardiovascular Biology, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
raw_author_name: Ateeqa Naim
raw_affiliation_strings: School of Natural Sciences, University of Kent, Canterbury, United Kingdom
raw_author_name: Matvey Pilagov
raw_affiliation_strings: School of Natural Sciences, University of Kent, Canterbury, United Kingdom
raw_author_name: Anthony Asencio
raw_affiliation_strings: Division of Cardiology, Medicine, University of Washington, Seattle Washington, USA; Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA; Department of Bioengineering, University of Washington, Seattle, Washington, USA
raw_author_name: Kyrah L. Turner
raw_affiliation_strings: School of Molecular Biosciences, Washington State University, Seattle, Washington, USA
raw_author_name: Weikang Ma
raw_affiliation_strings: Department of Biology, Illinois Institute of Technology, Chicago, Illinois, USA; Center for Synchrotron Radiation Research and Instrumentation, Illinois Institute of Technology, Chicago, Illinois, USA
raw_author_name: Galina Flint
raw_affiliation_strings: Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Center for Cardiovascular Biology, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA; Department of Bioengineering, University of Washington, Seattle, Washington, USA
raw_author_name: Siyao Jiang
raw_affiliation_strings: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China
raw_author_name: Jing Zhao
raw_affiliation_strings: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China
raw_author_name: Timothy S. McMillen
raw_affiliation_strings: Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA
raw_author_name: Christian Mandrycky
raw_affiliation_strings: Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA; School of Natural Sciences, University of Kent, Canterbury, United Kingdom
raw_author_name: Max Mahoney-Schaefer
raw_affiliation_strings: Division of Cardiology, Medicine, University of Washington, Seattle Washington, USA; Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA
raw_author_name: Thomas C. Irving
raw_affiliation_strings: Center for Synchrotron Radiation Research and Instrumentation, Illinois Institute of Technology, Chicago, Illinois, USA
raw_author_name: Bertrand C.W. Tanner
raw_affiliation_strings: Department of Integrative Physiology and Neuroscience, Washington State University, Seattle, Washington, USA
raw_author_name: Neil M. Kad
raw_affiliation_strings: School of Natural Sciences, University of Kent, Canterbury, United Kingdom
raw_author_name: Michael Regnier
raw_affiliation_strings: Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Center for Cardiovascular Biology, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA; Department of Bioengineering, University of Washington, Seattle, Washington, USA; Department of Neurobiology and Biophysics, University of Washington, Seattle, Washington, USA
raw_author_name: Farid Moussavi-Harami
raw_affiliation_strings: Division of Cardiology, Medicine, University of Washington, Seattle Washington, USA; Center of Translational Muscle Research, University of Washington, Seattle, Washington, USA; Center for Cardiovascular Biology, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA. Electronic address: moussavi@uw.edu