Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors
Year: 2025
Type: article
Language: en
Topic: Statistical Methods in Clinical Trials
Authors and affiliations:
raw_author_name: Dina ElHarouni
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
raw_author_name: Rosa Hernansaiz-Ballesteros
raw_affiliation_strings: 4Faculty of Medicine and Heidelberg University Hospital, Institute of Computational Biomedicine, Heidelberg University, Heidelberg, Germany
raw_author_name: Heike Peterziel
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
5Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany
raw_author_name: Gnana Prakash Balasubramanian
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Christopher Previti
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
6Omics IT and Data Management Core Facility (ODCF), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Kathrin Schramm
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
7Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany
raw_author_name: Mirjam Blattner-Johnson
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
7Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany
raw_author_name: Rolf Kabbe
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Barbara C. Jones
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
7Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany
8Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany
raw_author_name: Sina Oppermann
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
5Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany
9Institute for Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt, Germany
raw_author_name: David T.W. Jones
raw_affiliation_strings: 10National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
7Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany
raw_author_name: Stefan M. Pfister
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
8Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany
raw_author_name: Olaf Witt
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
5Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany
8Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany
raw_author_name: Julio Saez-Rodriguez
raw_affiliation_strings: 4Faculty of Medicine and Heidelberg University Hospital, Institute of Computational Biomedicine, Heidelberg University, Heidelberg, Germany
raw_author_name: Ina Oehme
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
5Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany
raw_author_name: Natalie Jäger
raw_affiliation_strings: 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Matthias Schlesner
raw_affiliation_strings: 11Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science and Medical Faculty, University of Augsburg, Augsburg, Germany