Unsupervised machine learning integrates genomic variants and EMR to unravel mechanisms of brain hemorrhage and epilepsy as early indicators of Alzheimer’s in down syndrome
Year: 2025
Type: article
Language: en
Topic: Genomics and Rare Diseases
Authors and affiliations:
raw_author_name: Yichuan Liu
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA. liuy5@email.chop.edu
Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Hui-Qi Qu
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Xiao Chang
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Frank D. Mentch
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Haijun Qiu
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Kenny Nguyen
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Garnet Eister
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Kayleigh Ostberg
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
raw_author_name: Joseph Glessner
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA
Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA
raw_author_name: Hakon Hakonarson
raw_affiliation_strings: Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Blvd Abramson Building, Philadelphia, PA, 19104, USA. hakonarson@email.chop.edu
Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. hakonarson@email.chop.edu
Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. hakonarson@email.chop.edu
Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. hakonarson@email.chop.edu
Faculty of Medicine, University of Iceland, Reykjavik, Iceland. hakonarson@email.chop.edu
Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Faculty of Medicine, University of Iceland, Reykjavik, Iceland