Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction
Year: 2025
Type: article
Language: en
Topic: DNA Repair Mechanisms
Authors and affiliations:
raw_author_name: Clara Vázquez García
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
raw_author_name: Benedikt Obermayer
raw_affiliation_strings: Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Core Unit Bioinformatics, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
raw_author_name: Baerbel Keller
raw_affiliation_strings: Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Mikhail Lebedin
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
raw_author_name: Christoph Ratswohl
raw_affiliation_strings: Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
raw_author_name: Hassan Abolhassani
raw_affiliation_strings: Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
raw_author_name: Antonia Busse
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité - Universitätsmedizin Berlin, Berlin, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
raw_author_name: Michela Di Virgilio
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
raw_author_name: Stephan Mathas
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Experimental and Clinical Research Center (ECRC), a junction cooperation between Charité and MDC, Berlin, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
raw_author_name: Dorothee Speiser
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Department of Gynecology with Breast Center, Hereditary Breast and Ovarian Cancer Center, Charité - Universitätsmedizin Berlin, Berlin, Germany
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
raw_author_name: Dieter Beule
raw_affiliation_strings: Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Core Unit Bioinformatics, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
raw_author_name: Qiang Pan-Hammarström
raw_affiliation_strings: Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Klaus Warnatz
raw_affiliation_strings: Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Kathrin de la Rosa
raw_affiliation_strings: Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de
Centre for Individualised Infection Medicine (CiiM), Hannover Medical School (MHH), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de
Department of Personalized Immunotherapy, Centre for Individualized Infection Medicine (CiiM), Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de
Centre for Individualised Infection Medicine (CiiM), Hannover Medical School (MHH), Hannover, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Department of Personalized Immunotherapy, Centre for Individualized Infection Medicine (CiiM), Helmholtz Centre for Infection Research (HZI), Hannover, Germany