Informal Caregiving in Patients With Atrial Fibrillation and Multimorbidity: A Cross-European Study of Caregiver Burden, Health-Related Quality of Life, and Caregiver Engagement
Year: 2025
Type: article
Language: en
Topic: Chronic Disease Management Strategies
Authors and affiliations:
raw_author_name: Caterina Bosio
raw_affiliation_strings: Caterina Bosio, PhD, Project Manager, EngageMinds HUB—Consumer, Food & Health Engagement Research Center, Catholic University of Sacred Heart, Cremona, Italy
Caterina Trevisan and Deirdre A. Lane designed the study and collected the data. Caterina Bosio, Dilara Usta, Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna conducted the data analysis. Caterina Bosio and Dilara Usta prepared the manuscript. Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna revised and supervised the manuscript critically. All the authors have approved the final version
Caterina Bosio declares that she received a research grant from the European Union's Horizon 2020 Program grant agreement number: 899871). Dilara Usta declares that she received a research grant from the European Union's Horizon 2022 Research and Innovation Program (grant agreement number: 101095470). Deirdre A. Lane declares that she has received investigator-initiated quality improvement grants from Bristol-Myers Squibb and Pfizer (paid to the Institution). She is a co-applicant on the AFFIRMO project on multimorbidity in atrial fibrillation (grant agreement number: 899871), ARISTOTELES project on artificial intelligence for management of chronic long-term conditions (grant agreement number: 101080189), and the TARGET project on digital twins for personalized management of atrial fibrillation and stroke (grant agreement number: 101136244), all of which are funded by the European Union's Horizon Europe Research and Innovation Program. Guendalina Graffigna received research grants from Chiesi, Alexion, Lundbeck, and Sanofi, and she has been a speaker for Sanofi, Roche Diabetes Care, and Merck Serono, all outside the submitted work. Caterina Trevisan reports no conflicts of interest
Published online 19 December 2025
raw_author_name: Dilara Usta
raw_affiliation_strings: Dilara Usta, PhD, RN, RN Postdoctoral Fellow, EngageMinds HUB—Consumer, Food & Health Engagement Research Center, Catholic University of Sacred Heart, Cremona, Italy
Caterina Bosio declares that she received a research grant from the European Union's Horizon 2020 Program grant agreement number: 899871). Dilara Usta declares that she received a research grant from the European Union's Horizon 2022 Research and Innovation Program (grant agreement number: 101095470). Deirdre A. Lane declares that she has received investigator-initiated quality improvement grants from Bristol-Myers Squibb and Pfizer (paid to the Institution). She is a co-applicant on the AFFIRMO project on multimorbidity in atrial fibrillation (grant agreement number: 899871), ARISTOTELES project on artificial intelligence for management of chronic long-term conditions (grant agreement number: 101080189), and the TARGET project on digital twins for personalized management of atrial fibrillation and stroke (grant agreement number: 101136244), all of which are funded by the European Union's Horizon Europe Research and Innovation Program. Guendalina Graffigna received research grants from Chiesi, Alexion, Lundbeck, and Sanofi, and she has been a speaker for Sanofi, Roche Diabetes Care, and Merck Serono, all outside the submitted work. Caterina Trevisan reports no conflicts of interest
Caterina Trevisan and Deirdre A. Lane designed the study and collected the data. Caterina Bosio, Dilara Usta, Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna conducted the data analysis. Caterina Bosio and Dilara Usta prepared the manuscript. Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna revised and supervised the manuscript critically. All the authors have approved the final version
Published online 19 December 2025
raw_author_name: Caterina Trevisan
raw_affiliation_strings: Caterina Trevisan, PhD, Associate Professor, Department of Medicine, University of Padova, Italy; Department of Medical Sciences, University of Ferrara, Italy; Aging Research Center, Karolinska Institutet, Stockholm, Sweden
Aging Research Center, Karolinska Institutet, Stockholm, Sweden
Department of Medical Sciences, University of Ferrara, Italy
Published online 19 December 2025
Caterina Bosio declares that she received a research grant from the European Union's Horizon 2020 Program grant agreement number: 899871). Dilara Usta declares that she received a research grant from the European Union's Horizon 2022 Research and Innovation Program (grant agreement number: 101095470). Deirdre A. Lane declares that she has received investigator-initiated quality improvement grants from Bristol-Myers Squibb and Pfizer (paid to the Institution). She is a co-applicant on the AFFIRMO project on multimorbidity in atrial fibrillation (grant agreement number: 899871), ARISTOTELES project on artificial intelligence for management of chronic long-term conditions (grant agreement number: 101080189), and the TARGET project on digital twins for personalized management of atrial fibrillation and stroke (grant agreement number: 101136244), all of which are funded by the European Union's Horizon Europe Research and Innovation Program. Guendalina Graffigna received research grants from Chiesi, Alexion, Lundbeck, and Sanofi, and she has been a speaker for Sanofi, Roche Diabetes Care, and Merck Serono, all outside the submitted work. Caterina Trevisan reports no conflicts of interest
Caterina Trevisan and Deirdre A. Lane designed the study and collected the data. Caterina Bosio, Dilara Usta, Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna conducted the data analysis. Caterina Bosio and Dilara Usta prepared the manuscript. Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna revised and supervised the manuscript critically. All the authors have approved the final version
raw_author_name: Deirdre A. Lane
raw_affiliation_strings: Deirdre A. Lane, PhD, Professor of Cardiovascular Health, Adjunct Professor, Department of Cardiovascular and Metabolic Medicine, Faculty of Health and Life Sciences, Institute of Life Course and Medical Sciences, University of Liverpool, United Kingdom; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, United Kingdom; Department of Clinical Medicine, Aalborg University, Denmark
Caterina Bosio declares that she received a research grant from the European Union's Horizon 2020 Program grant agreement number: 899871). Dilara Usta declares that she received a research grant from the European Union's Horizon 2022 Research and Innovation Program (grant agreement number: 101095470). Deirdre A. Lane declares that she has received investigator-initiated quality improvement grants from Bristol-Myers Squibb and Pfizer (paid to the Institution). She is a co-applicant on the AFFIRMO project on multimorbidity in atrial fibrillation (grant agreement number: 899871), ARISTOTELES project on artificial intelligence for management of chronic long-term conditions (grant agreement number: 101080189), and the TARGET project on digital twins for personalized management of atrial fibrillation and stroke (grant agreement number: 101136244), all of which are funded by the European Union's Horizon Europe Research and Innovation Program. Guendalina Graffigna received research grants from Chiesi, Alexion, Lundbeck, and Sanofi, and she has been a speaker for Sanofi, Roche Diabetes Care, and Merck Serono, all outside the submitted work. Caterina Trevisan reports no conflicts of interest
Published online 19 December 2025
Caterina Trevisan and Deirdre A. Lane designed the study and collected the data. Caterina Bosio, Dilara Usta, Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna conducted the data analysis. Caterina Bosio and Dilara Usta prepared the manuscript. Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna revised and supervised the manuscript critically. All the authors have approved the final version
raw_author_name: Guendalina Graffigna
raw_affiliation_strings: Guendalina Graffigna, PhD, Full Professor, EngageMinds HUB—Consumer, Food & Health Engagement Research Center, Catholic University of Sacred Heart, Cremona, Italy
Published online 19 December 2025
Caterina Bosio declares that she received a research grant from the European Union's Horizon 2020 Program grant agreement number: 899871). Dilara Usta declares that she received a research grant from the European Union's Horizon 2022 Research and Innovation Program (grant agreement number: 101095470). Deirdre A. Lane declares that she has received investigator-initiated quality improvement grants from Bristol-Myers Squibb and Pfizer (paid to the Institution). She is a co-applicant on the AFFIRMO project on multimorbidity in atrial fibrillation (grant agreement number: 899871), ARISTOTELES project on artificial intelligence for management of chronic long-term conditions (grant agreement number: 101080189), and the TARGET project on digital twins for personalized management of atrial fibrillation and stroke (grant agreement number: 101136244), all of which are funded by the European Union's Horizon Europe Research and Innovation Program. Guendalina Graffigna received research grants from Chiesi, Alexion, Lundbeck, and Sanofi, and she has been a speaker for Sanofi, Roche Diabetes Care, and Merck Serono, all outside the submitted work. Caterina Trevisan reports no conflicts of interest
Caterina Trevisan and Deirdre A. Lane designed the study and collected the data. Caterina Bosio, Dilara Usta, Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna conducted the data analysis. Caterina Bosio and Dilara Usta prepared the manuscript. Caterina Trevisan, Deirdre A. Lane, and Guendalina Graffigna revised and supervised the manuscript critically. All the authors have approved the final version