Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms
Year: 2025
Type: article
Language: en
Topic: RNA Research and Splicing
Authors and affiliations:
raw_author_name: Nuo Xu
raw_affiliation_strings: Department of Physiology, University of Toronto, Toronto, ON, Canada
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada
Centre for Addiction and Mental Health
raw_author_name: Katherine M. Rynard
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
University of Toronto
raw_author_name: Elizabeth Radley
raw_affiliation_strings: Department of Biochemistry, University of Toronto, Toronto, ON, Canada
University of Toronto
raw_author_name: Ai Tian
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
The Hospital for Sick Children
raw_author_name: Maahil Arshad
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada
Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada
University of Toronto
raw_author_name: Chaoying Long
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
Hospital for Sick Children
raw_author_name: Jimmy Ly
raw_affiliation_strings: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Whitehead Institute for Biomedical Research, Cambridge, MA, USA
Whitehead Institute for Biomedical Research
raw_author_name: Hua Luo
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
University of Toronto
raw_author_name: Ellie Hogan
raw_affiliation_strings: Department of Physiology, University of Toronto, Toronto, ON, Canada
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada
Centre for Addiction and Mental Health
raw_author_name: Maria Eleni Fafouti
raw_affiliation_strings: Department of Physiology, University of Toronto, Toronto, ON, Canada
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada
University of Toronto
raw_author_name: Melanie Davie
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada
University of Toronto
raw_author_name: Fatima Naimi
raw_affiliation_strings: Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
Hospital for Sick Children
raw_author_name: Yun Li
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
Hospital for Sick Children
raw_author_name: John A. Calarco
raw_affiliation_strings: Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
University of Toronto
raw_author_name: Brett Trost
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada
Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada
The Hospital for Sick Children
raw_author_name: Julien Muffat
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
University of Toronto
raw_author_name: Hyun O. Lee
raw_affiliation_strings: Department of Biochemistry, University of Toronto, Toronto, ON, Canada
University of Toronto
raw_author_name: Howard D. Lipshitz
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
University of Toronto
raw_author_name: Craig A. Smibert
raw_affiliation_strings: Department of Biochemistry, University of Toronto, Toronto, ON, Canada
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
University of Toronto
raw_author_name: Shreejoy J. Tripathy
raw_affiliation_strings: Department of Physiology, University of Toronto, Toronto, ON, Canada
Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada
University of Toronto