Discovery of a small-molecule inhibitor targeting human GMP synthetase
Year: 2025
Type: article
Language: en
Topic: Biochemical and Molecular Research
Authors and affiliations:
raw_author_name: Zhiyan Wang
raw_affiliation_strings: Department of Molecular Pharmacology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China
State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
raw_author_name: Rajamanikandan Sundarraj
raw_affiliation_strings: State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology
raw_author_name: Boao Mao
raw_affiliation_strings: State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology
raw_author_name: Jun-An Ma
raw_affiliation_strings: Department of Chemistry, State Key Laboratory Synthetic Biology, Tianjin University, Tianjin, 300072, China
raw_author_name: Kunrong Mei
raw_affiliation_strings: State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China. kmei@tju.edu.cn
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology
raw_author_name: Zhiguang Yuchi
raw_affiliation_strings: Department of Molecular Pharmacology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China. yuchi@tju.edu.cn
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin, 300192, China. yuchi@tju.edu.cn
State Key Laboratory of Synthetic Biology and Frontiers Science Center for Synthetic Biology; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China. yuchi@tju.edu.cn
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin, 300192, China