Genome-wide CRISPR Screening Reveals a PKA-Driven Resistance Mechanism to Metformin for Oral Cancer Prevention That Can Be Exploited by Combination with NSAIDs
Year: 2025
Type: article
Language: en
Topic: Metabolism, Diabetes, and Cancer
Authors and affiliations:
raw_author_name: Thomas S. Hoang
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Farhoud Faraji
raw_affiliation_strings: University of California San Diego Health 3 Department of Otolaryngology-Head and Neck Surgery, , San Diego, California
University of California San Diego Health 4 Gleiberman Head and Neck Cancer Center, Moores Cancer Center, , San Diego, California
University of California, San Diego 2 La Jolla
raw_author_name: Amaya N. Mendez-Molina
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Sendi Rafael Adame-Garcia
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Kuniaki Sato
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Tomohiko Ishikawa
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Pham Thuy Tien Vo
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Sydney I. Ramirez
raw_affiliation_strings: 5La Jolla Institute for Immunology, San Diego, California
University of California San Diego Health 6 Division of Infectious Diseases and Global Public Health, Department of Medicine, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Paola Y. Anguiano Quiroz
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Tracy Guo
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Katie Fan
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Xingyu Wu
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
UC San Diego Health System 3 San Diego, CA
raw_author_name: Alfredo A. Molinolo
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California, San Diego 4 La Jolla, CA
raw_author_name: Ezra E.W. Cohen
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
Moores Cancer Center 5 La Jolla, CA
raw_author_name: Prashant Mali
raw_affiliation_strings: University of California San Diego 7 Department of Bioengineering, , San Diego, California
University of California, San Diego 1 La Jolla, California
raw_author_name: Scott M. Lippman
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
UC San Diego Health System 3 San Diego, CA
raw_author_name: J. Silvio Gutkind
raw_affiliation_strings: University of California San Diego 1 Moores Cancer Center, , San Diego, California
University of California San Diego 2 Department of Pharmacology, , San Diego, California
University of California, San Diego 1 La Jolla, California