Comprehensive perturbation of transcription factors in human cardiomyocytes reveals the regulatory architecture of congenital heart disease
Year: 2025
Type: article
Language: en
Topic: Congenital heart defects research
Authors and affiliations:
raw_author_name: Chikara Takeuchi
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Sushama Sivakumar
raw_affiliation_strings: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Anjana Sundarrajan
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Yihan Wang
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Sean C Goetsch
raw_affiliation_strings: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Huan Zhao
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Lei Wang
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Mpathi Nzima
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Minnie Deng
raw_affiliation_strings: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Kartik N Kulkarni
raw_affiliation_strings: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Lin Xu
raw_affiliation_strings: Department of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Quantitative Biomedical Research Center, Peter O’Donnell Jr School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Jun Wu
raw_affiliation_strings: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Bruce A Posner
raw_affiliation_strings: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Maria H Chahrour
raw_affiliation_strings: Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA
Peter O’Donnell Jr Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: W. Lee Kraus
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Nikhil V Munshi
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA
Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
University of Texas Southwesten Medical Center
raw_author_name: Gary C Hon
raw_affiliation_strings: Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA
UT Southwestern Medical Center