Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing
Year: 2025
Type: article
Language: en
Topic: RNA Research and Splicing
Authors and affiliations:
raw_author_name: Tianji Yu
raw_affiliation_strings: Department of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Columbia University
raw_author_name: Jimin Yoon
raw_affiliation_strings: Department of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Columbia University
raw_author_name: Yimeng Zhu
raw_affiliation_strings: Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Columbia University
raw_author_name: Angelina Li
raw_affiliation_strings: Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Columbia University
raw_author_name: Brian J. Lee
raw_affiliation_strings: Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Columbia University
raw_author_name: Daniel F. Moakley
raw_affiliation_strings: Department of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Columbia University
raw_author_name: Jing Duan
raw_affiliation_strings: Department of Neurology, Shenzhen Children's Hospital, 7019# Yitian Road, Shenzhen, Guangdong, 518038, PR China
Shenzhen Children's Hospital
raw_author_name: Qiannian Deng
raw_affiliation_strings: Rare Disease Center, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong 518107, PR China
Shenzhen Medical Academy of Research and Translation
raw_author_name: Fanjia Hou
raw_affiliation_strings: Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518107, PR China
Shenzhen Bay Laboratory
raw_author_name: Mengfang Yan
raw_affiliation_strings: Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518107, PR China
Ph.D. Program, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong 518107, PR China
Ph.D. Program, Westlake University, Hangzhou, Zhejiang 310024, PR China
Shenzhen Bay Laboratory
raw_author_name: Vincenzo A. Gennarino
raw_affiliation_strings: Columbia Stem Cell Initiative, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA
Department of Genetics and Development, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA
Department of Neurology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA
Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Initiative for Columbia Ataxia and Tremor, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA
Columbia University
raw_author_name: Ke Zhang
raw_affiliation_strings: Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518107, PR China
Ph.D. Program, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong 518107, PR China
Rare Disease Center, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong 518107, PR China
Shenzhen Bay Laboratory
raw_author_name: Li Chen
raw_affiliation_strings: Department of Neurology, Shenzhen Children's Hospital, 7019# Yitian Road, Shenzhen, Guangdong, 518038, PR China
Shenzhen Children's Hospital
raw_author_name: Shan Zha
raw_affiliation_strings: Department of Microbiology and Immunology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Columbia university
raw_author_name: Chaolin Zhang
raw_affiliation_strings: Center for Motor Neuron Biology and Disease, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Department of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
Columbia University