Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo
Year: 2025
Type: article
Language: en
Topic: PARP inhibition in cancer therapy
Authors and affiliations:
raw_author_name: Priyadarshini Jaishankar
raw_affiliation_strings: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Galen J. Correy
raw_affiliation_strings: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Yusuke Matsui
raw_affiliation_strings: Gladstone Institute of Virology, Gladstone Institutes, 1650 Owens Street, San Francisco, California 94158, United States
raw_author_name: Takaya Togo
raw_affiliation_strings: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Moira M. Rachman
raw_affiliation_strings: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Maisie G.V. Stevens
raw_affiliation_strings: Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 Third St., San Francisco, California 94158, United States
raw_author_name: Eric R. Hantz
raw_affiliation_strings: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Jeffrey Zheng
raw_affiliation_strings: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Morgan E. Diolaiti
raw_affiliation_strings: Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 Third St., San Francisco, California 94158, United States
raw_author_name: Mauricio Montano
raw_affiliation_strings: Gladstone Institute of Virology, Gladstone Institutes, 1650 Owens Street, San Francisco, California 94158, United States
raw_author_name: Taha Y. Taha
raw_affiliation_strings: Gladstone Institute of Virology, Gladstone Institutes, 1650 Owens Street, San Francisco, California 94158, United States
raw_author_name: Julia Rosecrans
raw_affiliation_strings: Gladstone Institute of Virology, Gladstone Institutes, 1650 Owens Street, San Francisco, California 94158, United States
raw_author_name: Julius Pampel
raw_affiliation_strings: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Nevan J. Krogan
raw_affiliation_strings: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Brian K. Shoichet
raw_affiliation_strings: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Alan Ashworth
raw_affiliation_strings: Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 Third St., San Francisco, California 94158, United States
raw_author_name: Melanie Ott
raw_affiliation_strings: Gladstone Institute of Virology, Gladstone Institutes, 1650 Owens Street, San Francisco, California 94158, United States
raw_author_name: James S. Fraser
raw_affiliation_strings: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
raw_author_name: Adam R. Renslo
raw_affiliation_strings: Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, United States
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 Third St., San Francisco, California 94158, United States