Efficacy and safety of microbiota-targeted therapeutics in autoimmune and inflammatory rheumatic diseases: protocol for a systematic review and meta-analysis of randomised controlled trials
Year: 2025
Type: article
Language: en
Topic: Rheumatoid Arthritis Research and Therapies
Authors and affiliations:
raw_author_name: Maja Skov Kragsnaes
raw_affiliation_strings: OUH Frontline Centre for Applied Microbiota and Mucosal Barrier Research (MICARE), Odense University Hospital, Odense, Denmark
Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
OUH Frontline Centre for Applied Microbiota and Mucosal Barrier Research (MICARE), Odense University Hospital, Odense, Denmark d063631@dadlnet.dk
raw_author_name: Benoit Thomas P Gilbert
raw_affiliation_strings: Division of Rheumatology, HUG, Geneva, Switzerland
raw_author_name: Bjørk Khaliqi Sofíudóttir
raw_affiliation_strings: Department of Rheumatology, Odense University Hospital, Odense, Denmark
Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
raw_author_name: Christopher Michael Rooney
raw_affiliation_strings: Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute of Medical Research, University of Leeds, Yorkshire, UK
raw_author_name: Sebrina Maj-Britt Hansen
raw_affiliation_strings: Open Patient data Explorative Network, Odense University Hospital, Odense, Denmark
raw_author_name: Daniele Mauro
raw_affiliation_strings: Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy
raw_author_name: Benjamin H Mullish
raw_affiliation_strings: Department of Metabolism, Digestion and Reproduction, Division of Digestive Diseases, Imperial College London, London, UK
St Mary’s Hospital, Department of Gastroenterology and Hepatology, Imperial College Healthcare NHS Trust, London, UK
St Mary's Hospital, Department of Gastroenterology and Hepatology, Imperial College Healthcare NHS Trust, London, UK
raw_author_name: Anne-Sophie Bergot
raw_affiliation_strings: Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia
raw_author_name: Kulveer Singh Mankia
raw_affiliation_strings: Leeds Institute of Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
raw_author_name: Niti Goel
raw_affiliation_strings: Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina, USA
raw_author_name: Gunnstein Bakland
raw_affiliation_strings: Department of Rheumatology, University Hospital of North Norway, Tromsø, Norway
raw_author_name: Peter Holger Johnsen
raw_affiliation_strings: Department of Internal Medicine, University Hospital of North Norway, Harstad, Norway
raw_author_name: Jesus Miguens Blanco
raw_affiliation_strings: Department of Metabolism, Digestion and Reproduction, Division of Digestive Diseases, Imperial College London, London, UK
raw_author_name: Simone Li
raw_affiliation_strings: Microbiome Systems research group at the Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia
raw_author_name: Emilie Dumas
raw_affiliation_strings: Center for Inflammation Research, Unit for Molecular Immunology and Inflammation, Flanders Institute for Biotechnology, Ghent, Belgium
Department of Rheumatology, University Hospital Ghent, Ghent, Belgium
raw_author_name: Philip Rask Lage-Hansen
raw_affiliation_strings: Department of Rheumatology, Esbjerg and Grindsted Hospital, Esbjerg, Denmark
raw_author_name: Carlijn Wagenaar
raw_affiliation_strings: Amsterdam UMC, Amsterdam Rheumatology & Immunology Center, University of Amsterdam, Amsterdam, Netherlands
raw_author_name: Ghaith Bakdash
raw_affiliation_strings: Microbiotica, Chesterford Research Park, Little Chesterford, UK
raw_author_name: Mat Robinson
raw_affiliation_strings: Microbiotica, Chesterford Research Park, Little Chesterford, UK
raw_author_name: Karsten Kristiansen
raw_affiliation_strings: Laboratory of Integrative Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Julian R Marchesi
raw_affiliation_strings: Department of Metabolism, Digestion and Reproduction, Division of Digestive Diseases, Imperial College London, London, UK
raw_author_name: Georg Schett
raw_affiliation_strings: Department of Internal Medicine 3, Universitätsklinikum Erlangen, Erlangen, Germany
Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
raw_author_name: Mario M Zaiss
raw_affiliation_strings: Department of Internal Medicine 3, Universitätsklinikum Erlangen, Erlangen, Germany
Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
raw_author_name: Mine Orlu
raw_affiliation_strings: Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, UK
raw_author_name: Dirkjan van Schaadenburg
raw_affiliation_strings: Amsterdam UMC, Amsterdam Rheumatology & Immunology Center, University of Amsterdam, Amsterdam, Netherlands
raw_author_name: Jose U Scher
raw_affiliation_strings: Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine, New York, New York, USA
raw_author_name: Dennis McGonagle
raw_affiliation_strings: The Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK
raw_author_name: Dirk Elewaut
raw_affiliation_strings: Center for Inflammation Research, Unit for Molecular Immunology and Inflammation, Flanders Institute for Biotechnology, Ghent, Belgium
Department of Rheumatology, University Hospital Ghent, Ghent, Belgium
raw_author_name: Maxime Breban
raw_affiliation_strings: Service de rhumatologie, Hôpital Ambroise Paré, Neuilly-sur-Seine, Île-de-France, France
Université de Versailles St Quentin en Yvelines, Inserm, Infection et Inflammation, Université Paris-Saclay, Montigny le Btx, Île-de-France, France
raw_author_name: Peter Tugwell
raw_affiliation_strings: Department of Medicine, School of Epidemiology and Public Health, Bruyere Research Institute, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
raw_author_name: Axel Finckh
raw_affiliation_strings: Division of Rheumatology, HUG, Geneva, Switzerland
raw_author_name: Francesco Ciccia
raw_affiliation_strings: Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy
raw_author_name: Martin A Kriegel
raw_affiliation_strings: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
Department of Internal Medicine, Section of Rheumatology and Clinical Immunology, University Hospital Münster, Münster, Germany
Institute of Musculoskeletal Medicine, Department of Translational Rheumatology and Immunology, University of Münster, Münster, Germany
raw_author_name: Claire Daien
raw_affiliation_strings: Department of Rheumatology, CHU de Montpellier, Montpellier, France
raw_author_name: Torkell Ellingsen
raw_affiliation_strings: OUH Frontline Centre for Applied Microbiota and Mucosal Barrier Research (MICARE), Odense University Hospital, Odense, Denmark
Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
raw_author_name: Robin Christensen
raw_affiliation_strings: Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
the Parker Institute, Section for Biostatistics and Evidence-Based Research, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark