High BRAF variant allele frequency predicts poor outcomes in metastatic melanoma patients treated with BRAF/MEK inhibitors
Year: 2025
Type: article
Language: en
Topic: Melanoma and MAPK Pathways
Authors and affiliations:
raw_author_name: Michele Guida
raw_affiliation_strings: Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy
raw_author_name: Benedetta Apollonio
raw_affiliation_strings: , Viale Orazio Flacco 65, 70124, Bari, Italy. b.apollonio@oncologico.bari.it
Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy. b.apollonio@oncologico.bari.it
Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy
raw_author_name: Luca Romano
raw_affiliation_strings: Unit of Medical Oncology, University of Perugia, Perugia, Italy
raw_author_name: Francesco Spagnolo
raw_affiliation_strings: Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy
Genetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
raw_author_name: Pietro Quaglino
raw_affiliation_strings: Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy
raw_author_name: Roberta Depenni
raw_affiliation_strings: Oncology Unit, AOU Policlinico Modena, Modena, Italy
raw_author_name: Rosamaria Pinto
raw_affiliation_strings: Molecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy
raw_author_name: Teresa Squicciarini
raw_affiliation_strings: Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy
raw_author_name: Livia Fucci
raw_affiliation_strings: Pathology Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy
raw_author_name: Piergiorgio Di Tullio
raw_affiliation_strings: Unit of Medical Oncology and Biomolecular Therapy, Department of Medical and Surgical Sciences, University of Foggia, Policlinico Riuniti, Foggia, Italy
raw_author_name: Maria Chiara Scaini
raw_affiliation_strings: Immunology and Molecular Oncology Unit, Veneto Institute of Oncology - IOV IRCCS, Padua, Italy
raw_author_name: Maria Teresa Maccallini
raw_affiliation_strings: UOSD Sarcomas and Rare Tumors-IRCCS Regina Elena National Cancer Institute, Rome, Italy
raw_author_name: Alice Indini
raw_affiliation_strings: Unit of Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
raw_author_name: Teresa Troiani
raw_affiliation_strings: Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80131, Naples, Italy
raw_author_name: Iole Natalicchio
raw_affiliation_strings: Unit of Medical Oncology and Biomolecular Therapy, Department of Medical and Surgical Sciences, University of Foggia, Policlinico Riuniti, Foggia, Italy
raw_author_name: Sonia Brugnara
raw_affiliation_strings: Department of Medical Oncology, Santa Chiara Hospital, Trento, Italy
raw_author_name: Maurizio Lombardo
raw_affiliation_strings: Department of Dermatology, ASST Sette Laghi, Varese, Italy
raw_author_name: Cristina Pellegrini
raw_affiliation_strings: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy
raw_author_name: Paola Queirolo
raw_affiliation_strings: Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, European Institute of Oncology IRCCS, Milan, Italy
raw_author_name: Fabiana Perrone
raw_affiliation_strings: Medical Oncology Unit, University Hospital of Parma, Parma, Italy
raw_author_name: Alessandro Minisini
raw_affiliation_strings: Department of Oncology, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy
raw_author_name: Marco Tucci
raw_affiliation_strings: Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy
raw_author_name: Raffaele Conca
raw_affiliation_strings: Division of Medical Oncology, Department of Onco-Hematology, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy
raw_author_name: Silvia Costabile
raw_affiliation_strings: Unit of Medical Oncology, University of Perugia, Perugia, Italy
raw_author_name: Miriam Macrì
raw_affiliation_strings: Unit of Medical Oncology, University of Perugia, Perugia, Italy
raw_author_name: Enrica Tanda
raw_affiliation_strings: Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy
Genetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
raw_author_name: Elena Croce
raw_affiliation_strings: Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy
Genetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
raw_author_name: Rebecca Senetta
raw_affiliation_strings: Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy
raw_author_name: Paolo Fava
raw_affiliation_strings: Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy
raw_author_name: Giuseppe Pugliese
raw_affiliation_strings: Oncology Unit, AOU Policlinico Modena, Modena, Italy
raw_author_name: Stefania Pellegrini
raw_affiliation_strings: Immunology and Molecular Oncology Unit, Veneto Institute of Oncology - IOV IRCCS, Padua, Italy
raw_author_name: Elisa Melucci
raw_affiliation_strings: Pathology Department-IRCCS Regina Elena National Cancer Institute, Rome, Italy
raw_author_name: Michele Del Vecchio
raw_affiliation_strings: Unit of Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
raw_author_name: Francesco Caraglia
raw_affiliation_strings: Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80131, Naples, Italy
raw_author_name: Salvatore Girlando
raw_affiliation_strings: Pathological Anatomy, Santa Chiara Hospital, Trento, Italy
raw_author_name: Simona De Summa
raw_affiliation_strings: Molecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy
raw_author_name: Sabino Strippoli
raw_affiliation_strings: Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy
raw_author_name: on behalf of the Italian Melanoma Intergroup (IMI)