Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk
Year: 2025
Type: article
Language: en
Topic: Genetic Associations and Epidemiology
Authors and affiliations:
raw_author_name: Yuk Yee Leung
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Pavel P. Kuksa
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Luke Carter
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Jeffrey Cifello
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Emily Greenfest-Allen
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Otto Valladares
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Louisa Boateng
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Shannon Laub
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Natalia Tulina
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Sofia Moura
raw_affiliation_strings: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA
raw_author_name: Aura Ramirez
raw_affiliation_strings: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA
raw_author_name: Katrina Celis
raw_affiliation_strings: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA
raw_author_name: Fulai Jin
raw_affiliation_strings: Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH USA
raw_author_name: Ru Feng
raw_affiliation_strings: Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA
Department of Neurology, Columbia University, New York, NY USA
raw_author_name: Gao Wang
raw_affiliation_strings: Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA
Department of Neurology, Columbia University, New York, NY USA
raw_author_name: Phil De Jager
raw_affiliation_strings: Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA
Department of Neurology, Columbia University, New York, NY USA
raw_author_name: Jeffery M. Vance
raw_affiliation_strings: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA
raw_author_name: Liyong Wang
raw_affiliation_strings: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Struan F. A. Grant
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA USA
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
Divisions of Human Genetics and Endocrinology & Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA USA
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Gerard D. Schellenberg
raw_affiliation_strings: Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Alessandra Chesi
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA USA
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
raw_author_name: Li-San Wang
raw_affiliation_strings: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA