The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
Year: 2025
Type: article
Language: en
Topic: Cancer, Hypoxia, and Metabolism
Authors and affiliations:
raw_author_name: Niklas Herrle
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Pedro F Malacarne
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Timothy Warwick
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Alfredo Cabrera-Orefice
raw_affiliation_strings: Goethe University, Functional Proteomics, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Yiheng Chen
raw_affiliation_strings: McGill University, Department of Human Genetics, Montréal, QC, Canada
McGill University, Lady Davis Institute, Jewish General Hospital, Montréal, QC, Canada
raw_author_name: Maedeh Gheisari
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Souradeep Chatterjee
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Matthias S Leisegang
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Tamim Sarakpi
raw_affiliation_strings: Else Kroener-Fresenius Center for Nephrological Research, Frankfurt am Main, Germany
Goethe University, Department of Internal Medicine 4, Nephrology, Frankfurt am Main, Germany
raw_author_name: Sarah Wionski
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Melina Lopez
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Carine Kader
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Tom Teichmann
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Maria-Kyriaki Drekolia
raw_affiliation_strings: Heidelberg University, Department of Vascular Dysfunction, Mannheim, Germany
raw_author_name: Ina Koch
raw_affiliation_strings: Goethe University, Institute of Computer Science, Frankfurt am Main, Germany
raw_author_name: Marcus Keßler
raw_affiliation_strings: Goethe University, Institute of Computer Science, Frankfurt am Main, Germany
raw_author_name: Sabine Klein
raw_affiliation_strings: University Hospital Münster, Department of Internal Medicine B, Münster, Germany
raw_author_name: Frank Erhard Uschner
raw_affiliation_strings: University Hospital Münster, Department of Internal Medicine B, Münster, Germany
raw_author_name: Jonel Trebicka
raw_affiliation_strings: University Hospital Münster, Department of Internal Medicine B, Münster, Germany
raw_author_name: Steffen Brunst
raw_affiliation_strings: Goethe University, Institute for Pharmaceutical Chemistry, Frankfurt am Main, Germany
raw_author_name: Ewgenij Proschak
raw_affiliation_strings: Goethe University, Institute for Pharmaceutical Chemistry, Frankfurt am Main, Germany
raw_author_name: Stefan Günther
raw_affiliation_strings: Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
raw_author_name: Mónica Rosas-Lemus
raw_affiliation_strings: University of New Mexico, Department of Molecular Genetics and Microbiology, Health Sciences Center, Albuquerque, NM, USA
raw_author_name: Nina Baumgarten
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Computational Genomic Medicine, Frankfurt am Main, Germany
raw_author_name: Stephan Klatt
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Vascular Signaling, Frankfurt am Main, Germany
raw_author_name: Thimoteus Speer
raw_affiliation_strings: Else Kroener-Fresenius Center for Nephrological Research, Frankfurt am Main, Germany
Goethe University, Department of Internal Medicine 4, Nephrology, Frankfurt am Main, Germany
raw_author_name: Sofia-Iris Bibli
raw_affiliation_strings: Heidelberg University, Department of Vascular Dysfunction, Mannheim, Germany
raw_author_name: Marta Segarra
raw_affiliation_strings: Goethe University, Institute of Cell Biology and Neuroscience, Frankfurt am Main, Germany
raw_author_name: Amparo Acker-Palmer
raw_affiliation_strings: Goethe University, Institute of Cell Biology and Neuroscience, Frankfurt am Main, Germany
raw_author_name: Julian U G Wagner
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University Frankfurt, Institute for Cardiovascular Regeneration, Frankfurt am Main, Germany
raw_author_name: Ilka Wittig
raw_affiliation_strings: Goethe University, Functional Proteomics, Frankfurt am Main, Germany
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany
raw_author_name: Stefanie Dimmeler
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University Frankfurt, Institute for Cardiovascular Regeneration, Frankfurt am Main, Germany
raw_author_name: Marcel H Schulz
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Computational Genomic Medicine, Frankfurt am Main, Germany
raw_author_name: J B Richards
raw_affiliation_strings: 5 Prime Sciences Inc, Montréal, QC, Canada
King's College London, Department of Twin Research, London, UK
McGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montréal, QC, Canada
McGill University, Department of Human Genetics, Montréal, QC, Canada
McGill University, Department of Medicine, Montréal, QC, Canada
McGill University, Lady Davis Institute, Jewish General Hospital, Montréal, QC, Canada
raw_author_name: Ralf Gilsbach
raw_affiliation_strings: Heidelberg University Hospital, Institute of Experimental Cardiology, Heidelberg, Germany
raw_author_name: Travis T Denton
raw_affiliation_strings: Washington State University Health Sciences Spokane, Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Spokane, WA, USA
Washington State University Health Sciences Spokane, Department of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Spokane, WA, USA
Washington State University Health Sciences Spokane, Steve Gleason Institute for Neuroscience, Spokane, WA, USA
raw_author_name: Ingrid Fleming
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany
Goethe University, Institute for Vascular Signaling, Frankfurt am Main, Germany
raw_author_name: Luciana Hannibal
raw_affiliation_strings: University of Freiburg, CIBSS - Centre for Integrative Biological Signalling Studies, Freiburg, Germany
University of Freiburg, Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Adolescent Medicine and Neonatology, Freiburg im Breisgau, Germany
raw_author_name: Ralf P Brandes
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany. brandes@vrc.uni-frankfurt.de
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany. brandes@vrc.uni-frankfurt.de
raw_author_name: Flávia Rezende
raw_affiliation_strings: German Center of Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany. rezende@vrc.uni-frankfurt.de
Goethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany. rezende@vrc.uni-frankfurt.de