Targeting IMPDH to inhibit SAMHD1 in <i>KMT2A</i> -rearranged leukaemia
Year: 2025
Type: article
Language: en
Topic: Biochemical and Molecular Research
Authors and affiliations:
raw_author_name: Yolande Klootsema
raw_affiliation_strings: Department of Women’s and Children’s Health, Karolinska Institutet
Division of Paediatric Oncology and Surgery, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Nikolaos Tsesmetzis
raw_affiliation_strings: Department of Women’s and Children’s Health, Karolinska Institutet
Division of Paediatric Oncology and Surgery, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Sushma Sharma
raw_affiliation_strings: Umeå University
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
raw_author_name: Sophia Hofmann
raw_affiliation_strings: Karolinska Institutet
Center for Haematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
raw_author_name: Jonas Thier
raw_affiliation_strings: Karolinska Institutet
Center for Haematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
raw_author_name: Christopher Dirks
raw_affiliation_strings: Karolinska Institutet
Science for Life Laboratory (SciLifeLab), Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Femke M. Hormann
raw_affiliation_strings: Karolinska Institutet
Science for Life Laboratory (SciLifeLab), Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Miriam Yagüe-Capilla
raw_affiliation_strings: Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla
Karolinska Institutet
Universidad de Sevilla
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain
Science for Life Laboratory (SciLifeLab), Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Anna Bohlin
raw_affiliation_strings: Karolinska Institutet
Karolinska University Hospital
Center for Haematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
Department of Medicine, Division of Hematology, Karolinska University Hospital, Huddinge, Sweden
raw_author_name: Sofia Bengtzen
raw_affiliation_strings: Karolinska Institutet
Karolinska University Hospital
Department of Medicine, Division of Hematology, Karolinska University Hospital, Huddinge, Sweden
Center for Haematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
raw_author_name: Sören Lehmann
raw_affiliation_strings: Karolinska Institutet
Karolinska University Hospital
Uppsala University
Hematology Unit, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Medicine, Division of Hematology, Karolinska University Hospital, Huddinge, Sweden
raw_author_name: Andrei Chabes
raw_affiliation_strings: Umeå University
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
raw_author_name: Martin Jädersten
raw_affiliation_strings: Karolinska Institutet
Karolinska University Hospital
Center for Haematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
Department of Medicine, Division of Hematology, Karolinska University Hospital, Huddinge, Sweden
raw_author_name: Vanessa Lundin
raw_affiliation_strings: Karolinska Institutet
Center for Haematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
raw_author_name: Sean G. Rudd
raw_affiliation_strings: Karolinska Institutet
Science for Life Laboratory (SciLifeLab), Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Ingrid Lilienthal
raw_affiliation_strings: Department of Women’s and Children’s Health, Karolinska Institutet
Division of Paediatric Oncology and Surgery, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Nikolas Herold
raw_affiliation_strings: Department of Women’s and Children’s Health, Karolinska Institutet
Karolinska University Hospital
Division of Paediatric Oncology and Surgery, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
Paediatric Oncology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden