From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models
Year: 2025
Type: article
Language: en
Topic: Mass Spectrometry Techniques and Applications
Authors and affiliations:
raw_author_name: Stefania Alexandra Iakab
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Jonas Cordes
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Thomas Enzlein
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Florian Keller
raw_affiliation_strings: CeMOS Research and Transfer Center 3D‐Models and Imaging Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, 3D-Models and Imaging, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Kevin Kastner
raw_affiliation_strings: CeMOS Research and Transfer Center Virtual Engineering Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, Virtual Engineering, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Theresa Mulholland
raw_affiliation_strings: DKFZ Hector Cancer Institute at University Medical Center Mannheim Theodor‐Kutzer‐Ufer 1‐3 68167 Mannheim Germany
Department of Medicine II University Medical Center Mannheim Medical Faculty Mannheim Heidelberg University Theodor‐Kutzer‐Ufer 1‐3 68167 Mannheim Germany
German Cancer Consortium (DKTK) Im Neuenheimer Feld 280 69120 Heidelberg Germany
Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Germany
DKFZ Hector Cancer Institute at University Medical Center Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
raw_author_name: Björn Christian Fröhlich
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Lars Gruber
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
Medical Faculty Heidelberg University  Im Neuenheimer Feld 672 69120 Heidelberg Germany
Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: James Lucas Cairns
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
Medical Faculty Heidelberg University  Im Neuenheimer Feld 672 69120 Heidelberg Germany
Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Stefan Schmidt
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Mathias Hafner
raw_affiliation_strings: CeMOS Research and Transfer Center 3D‐Models and Imaging Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, 3D-Models and Imaging, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Richard Schneider
raw_affiliation_strings: Merck Healthcare KGaA  Frankfurter Str. 250 64293 Darmstadt Germany
Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany
raw_author_name: Johannes Betge
raw_affiliation_strings: DKFZ Hector Cancer Institute at University Medical Center Mannheim Theodor‐Kutzer‐Ufer 1‐3 68167 Mannheim Germany
Department of Medicine II University Medical Center Mannheim Medical Faculty Mannheim Heidelberg University Theodor‐Kutzer‐Ufer 1‐3 68167 Mannheim Germany
German Cancer Consortium (DKTK) Im Neuenheimer Feld 280 69120 Heidelberg Germany
Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Germany
Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
DKFZ Hector Cancer Institute at University Medical Center Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
raw_author_name: Frank Fischer
raw_affiliation_strings: Merck KGaA  Frankfurter Str. 250 64293 Darmstadt Germany
Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany
raw_author_name: Julian Reichwald
raw_affiliation_strings: CeMOS Research and Transfer Center Virtual Engineering Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
CeMOS Research and Transfer Center, Virtual Engineering, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Rüdiger Rudolf
raw_affiliation_strings: CeMOS Research and Transfer Center 3D‐Models and Imaging Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
Mannheim Center for Translational Neuroscience (MCTN) Medical Faculty Mannheim Heidelberg University  Theodor‐Kutzer‐Ufer 1‐3 68167 Mannheim Germany
Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
CeMOS Research and Transfer Center, 3D-Models and Imaging, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
raw_author_name: Carsten Hopf
raw_affiliation_strings: CeMOS Research and Transfer Center Mass Spectrometry and Optical Spectroscopy Technische Hochschule Mannheim  Paul‐Wittsack‐Str. 10 68163 Mannheim Germany
Mannheim Center for Translational Neuroscience (MCTN) Medical Faculty Mannheim Heidelberg University  Theodor‐Kutzer‐Ufer 1‐3 68167 Mannheim Germany
Medical Faculty Heidelberg University  Im Neuenheimer Feld 672 69120 Heidelberg Germany
Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
CeMOS Research and Transfer Center, Mass Spectrometry and Optical Spectroscopy, Technische Hochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany