A Cre-mediated copy number variant compromises the reliability of a <i>LoxP-STOP-LoxP</i> - <i>PLAG1</i> driven brain tumor model
Year: 2025
Type: article
Language: en
Topic: Genomic variations and chromosomal abnormalities
Authors and affiliations:
raw_author_name: Jan Vaillant
raw_affiliation_strings: Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ) ,
Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) , Heidelberg, (J.V., A.W., A.B.-Y., M.-K.K., D.T.W.J.)
Faculty of Biosciences, Heidelberg University , Heidelberg,
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
Heidelberg University Faculty of Biosciences, ; Heidelberg,
German Cancer Research Center (DKFZ) , Heidelberg,
Hopp Children’s Cancer Center Heidelberg (KiTZ) Division of Pediatric Glioma Research, , Heidelberg,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
raw_author_name: Sangita Pal
raw_affiliation_strings: Broad Institute of MIT and Harvard , Cambridge
Department of Medical Oncology, Dana-Farber Cancer Institute , Boston
Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center , Boston
Harvard Medical School , Boston
Broad Institute of MIT and Harvard , Cambridge, MA,
Department of Medical Oncology , Dana-Farber Cancer Institute, Boston, MA,
Department of Pediatric Oncology , Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA,
Harvard Medical School , Boston, MA 02115,
raw_author_name: Jan Müller
raw_affiliation_strings: Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
German Cancer Research Center (DKFZ) , Heidelberg,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
raw_author_name: Andrea Wittmann
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) , Heidelberg, (J.V., A.W., A.B.-Y., M.-K.K., D.T.W.J.)
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
Hopp Children’s Cancer Center Heidelberg (KiTZ) Division of Pediatric Glioma Research, , Heidelberg,
German Cancer Research Center (DKFZ) , Heidelberg,
raw_author_name: Akosua Boakye-Yiadom
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) , Heidelberg, (J.V., A.W., A.B.-Y., M.-K.K., D.T.W.J.)
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
Hopp Children’s Cancer Center Heidelberg (KiTZ) Division of Pediatric Glioma Research, , Heidelberg,
German Cancer Research Center (DKFZ) , Heidelberg,
raw_author_name: Philipp Sievers
raw_affiliation_strings: Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ) , Heidelberg,
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg , Heidelberg,
Clinical Cooperation Unit Neuropathology , German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg,
raw_author_name: Paula Zimmer
raw_affiliation_strings: Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ) ,
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
Hopp Children’s Cancer Center Heidelberg (KiTZ) Developmental Origins of Pediatric Cancer Junior Research Group, , Heidelberg,
German Cancer Research Center (DKFZ) , Heidelberg,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
raw_author_name: Melanie Schoof
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf ,
Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf , Hamburg,
Research Institute Children’s Cancer Center Hamburg ,
University Medical Center Hamburg-Eppendorf Department of Pediatric Hematology and Oncology, ,
raw_author_name: Franziska Schelb
raw_affiliation_strings: Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ) ,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) , Heidelberg,
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
German Cancer Research Center (DKFZ) , Heidelberg,
Hopp Children’s Cancer Center Heidelberg (KiTZ) Developmental Origins of Pediatric Cancer Junior Research Group, , Heidelberg,
raw_author_name: Nina Hofmann
raw_affiliation_strings: Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) , Heidelberg,
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
German Cancer Research Center (DKFZ) , Heidelberg,
Division of Pediatric Neurooncology , Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
raw_author_name: Michaela-Kristina Keck
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) , Heidelberg, (J.V., A.W., A.B.-Y., M.-K.K., D.T.W.J.)
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
Hopp Children’s Cancer Center Heidelberg (KiTZ) Division of Pediatric Glioma Research, , Heidelberg,
German Cancer Research Center (DKFZ) , Heidelberg,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
raw_author_name: Tessa Fabian
raw_affiliation_strings: Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ) ,
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
German Cancer Research Center (DKFZ) , Heidelberg,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
Hopp Children’s Cancer Center Heidelberg (KiTZ) Developmental Origins of Pediatric Cancer Junior Research Group, , Heidelberg,
raw_author_name: Ulrich Schüller
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf ,
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf ,
Research Institute Children’s Cancer Center Hamburg ,
University Medical Center Hamburg-Eppendorf Department of Pediatric Hematology and Oncology, ,
raw_author_name: Marc Zuckermann
raw_affiliation_strings: Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) , Heidelberg,
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
German Cancer Research Center (DKFZ) , Heidelberg,
Hopp Children’s Cancer Center Heidelberg (KiTZ) Developmental Origins of Pediatric Cancer Junior Research Group, , Heidelberg,
raw_author_name: Rameen Beroukhim
raw_affiliation_strings: Broad Institute of MIT and Harvard , Cambridge
Department of Medical Oncology, Dana-Farber Cancer Institute , Boston
Harvard Medical School , Boston
Harvard Medical School , Boston, MA 02115,
Broad Institute of MIT and Harvard , Cambridge, MA,
Department of Medical Oncology , Dana-Farber Cancer Institute, Boston, MA,
raw_author_name: Pratiti Bandopadhayay
raw_affiliation_strings: Broad Institute of MIT and Harvard , Cambridge
Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center , Boston
Harvard Medical School , Boston
Broad Institute of MIT and Harvard , Cambridge, MA,
Department of Pediatric Oncology , Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA,
Harvard Medical School , Boston, MA 02115,
raw_author_name: David T W Jones
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) , Heidelberg, (J.V., A.W., A.B.-Y., M.-K.K., D.T.W.J.)
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
These authors jointly supervised this study
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German
Hopp Children’s Cancer Center Heidelberg (KiTZ) Division of Pediatric Glioma Research, , Heidelberg,
German Cancer Research Center (DKFZ) , Heidelberg,
raw_author_name: Lena M Kutscher
raw_affiliation_strings: Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ) ,
Hopp Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital ,
Hopp Children’s Cancer Center Heidelberg (KiTZ) Developmental Origins of Pediatric Cancer Junior Research Group, , Heidelberg,
These authors jointly supervised this study
German Cancer Research Center (DKFZ) , Heidelberg,
DKFZ and Heidelberg University Hospital National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between , German