Deciphering bisphenol A (BPA)-elicited osteoarthritis mechanisms through network toxicology and molecular docking, then de novo generation of novel therapeutic candidates
Year: 2025
Type: article
Language: en
Topic: Effects and risks of endocrine disrupting chemicals
Authors and affiliations:
raw_author_name: Sumei Xu
raw_affiliation_strings: Department of Biomedical Informatics, University at Buffalo, Buffalo, NY, 14260, USA
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Phase I Clinical Trial Center, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
raw_author_name: Liping Jiang
raw_affiliation_strings: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China
raw_author_name: Zhuo Zhang
raw_affiliation_strings: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China
raw_author_name: Xin Luo
raw_affiliation_strings: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China
raw_author_name: Wei Wu
raw_affiliation_strings: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China
raw_author_name: Huilan Wu
raw_affiliation_strings: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China
raw_author_name: Zhichun Huang
raw_affiliation_strings: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China
raw_author_name: Zackary Falls
raw_affiliation_strings: Department of Biomedical Informatics, University at Buffalo, Buffalo, NY, 14260, USA
raw_author_name: Ram Samudrala
raw_affiliation_strings: Department of Biomedical Informatics, University at Buffalo, Buffalo, NY, 14260, USA. ram@compbio.org
Department of Biomedical Informatics, University at Buffalo, Buffalo, NY, 14260, USA
raw_author_name: Zhirong Tan
raw_affiliation_strings: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China. 803119@csu.edu.cn
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China. 803119@csu.edu.cn
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China. 803119@csu.edu.cn
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Hunan, 410008, Changsha, P. R. China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Hunan, 410078, Changsha, P. R. China
Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Hunan, 410078, Changsha, P.R. China