Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases
Year: 2025
Type: article
Language: en
Topic: Single-cell and spatial transcriptomics
Authors and affiliations:
raw_author_name: Yunlong Ma
raw_affiliation_strings: Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. yunlong.ma@pennmedicine.upenn.edu
Lifespan Brain Institute at Penn Med and the Children's Hospital of Philadelphia, Philadelphia, PA, USA. yunlong.ma@pennmedicine.upenn.edu
Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. yunlong.ma@pennmedicine.upenn.edu
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Lifespan Brain Institute at Penn Med and the Children's Hospital of Philadelphia, Philadelphia, PA, USA
Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Yinghao Yao
raw_affiliation_strings: Department of Biomedical Informatics, Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Yijun Zhou
raw_affiliation_strings: Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Wei Dai
raw_affiliation_strings: Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Jingjing Li
raw_affiliation_strings: Department of Biomedical Informatics, Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Yuanyuan Gui
raw_affiliation_strings: Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Haojun Sun
raw_affiliation_strings: Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Zhengbiao Zhu
raw_affiliation_strings: Department of Biomedical Informatics, Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Dingping Jiang
raw_affiliation_strings: Department of Biomedical Informatics, Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Cheng Chen
raw_affiliation_strings: Department of Biomedical Informatics, Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Chunyu Deng
raw_affiliation_strings: Department of Biomedical Informatics, Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China
raw_author_name: Yizhou Huang
raw_affiliation_strings: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China
raw_author_name: Haijun Han
raw_affiliation_strings: School of Medicine, Hangzhou City University, Hangzhou, China
raw_author_name: Jianhong Zhou
raw_affiliation_strings: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China
raw_author_name: Jianzhong Su
raw_affiliation_strings: Department of Biomedical Informatics, Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China. sujz@wmu.edu.cn
Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, China. sujz@wmu.edu.cn
Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. sujz@wmu.edu.cn
State Key Laboratory of Eye Health, Eye hospital, Wenzhou Medical University, Wenzhou, China. sujz@wmu.edu.cn
Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, China