Auranofin attenuates TOPBP1-mediated ATR replication stress response and improves chemotherapeutic response in breast tumor models
Year: 2025
Type: article
Language: en
Topic: DNA Repair Mechanisms
Authors and affiliations:
raw_author_name: Shuai Ma
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Yingying Han
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Rui Gu
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Qi Chen
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Qiushi Guo
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Yuan Yue
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Cheng Cao
raw_affiliation_strings: Center for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, USTC, Hefei, China
raw_author_name: Ling Liu
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China
raw_author_name: Zhenzhen Yang
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Yan Qin
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Ying Yang
raw_affiliation_strings: Core Facilities Center, Capital Medical University, Beijing, China
raw_author_name: Kai Zhang
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Fei Liu
raw_affiliation_strings: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China
raw_author_name: Lin Liu
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China
raw_author_name: Na Yang
raw_affiliation_strings: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China
raw_author_name: Jihui Hao
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Jie Yang
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Zhi Yao
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China
raw_author_name: Xiaoyun Mao
raw_affiliation_strings: Breast Surgery, The First Affiliated Hospital of China Medical University, Liaoning, China
raw_author_name: Lei Shi
raw_affiliation_strings: Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), National Key Laboratory of Blood Science, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China