Intracerebral Distribution of Drugs with Diverse Blood–brain Barrier Transport Characteristics: In vivo Analysis using Brain Microdialysis in Cynomolgus Monkeys
Year: 2025
Type: article
Language: en
Topic: Drug Transport and Resistance Mechanisms
Authors and affiliations:
raw_author_name: Takuya Fujita
raw_affiliation_strings: Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical, Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, Japan. fujita-t@ph.ritsumei.ac.jp
Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical, Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, Japan
raw_author_name: Yukari Kamikozawa
raw_affiliation_strings: DMPK Research Laboratories, Sohyaku Innovative Research Division, Tanabe Pharma Corporation, 1000 Kamoshida-Cho, Aoba-Ku, Yokohama, Japan
raw_author_name: Makoto Ozawa
raw_affiliation_strings: Pharmaceutical and Analytical Research Department, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa, Tokyo, Japan
raw_author_name: Yoriko Tajima
raw_affiliation_strings: Group 1, Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan
raw_author_name: Toshiki Kurosawa
raw_affiliation_strings: Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan
raw_author_name: Yuki Katagiri
raw_affiliation_strings: Preclinical Research Unit, Research and Development Division, Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-Naka, Konohana-Ku, Osaka, Japan
raw_author_name: Hiroko Kawaguchi
raw_affiliation_strings: Preclinical Research Unit, Research and Development Division, Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-Naka, Konohana-Ku, Osaka, Japan
raw_author_name: Akito Kakuuchi
raw_affiliation_strings: Section 3, Oncology Medical Affairs, Ono Pharmaceutical Co., Ltd., Osaka, Japan
raw_author_name: Rei Miyamoto
raw_affiliation_strings: Pharmacokinetics Research Laboratories, Taiho Pharmaceutical Co., , Ltd. 3 Okubo, Tsukuba, Ibaraki, Japan
Pharmacokinetics Research Laboratories, Taiho Pharmaceutical Co.,
, Ltd. 3 Okubo, Tsukuba, Ibaraki, Japan
raw_author_name: Kentaro Wakayama
raw_affiliation_strings: Pharmacokinetics Research Laboratories, Taiho Pharmaceutical Co., , Ltd. 3 Okubo, Tsukuba, Ibaraki, Japan
Pharmacokinetics Research Laboratories, Taiho Pharmaceutical Co.,
, Ltd. 3 Okubo, Tsukuba, Ibaraki, Japan
raw_author_name: Mika Nagai
raw_affiliation_strings: Drug Research Center, KAKEN PHARMACEUTICAL CO., LTD, 14 Shinomiya Minamigawara-Cho, Yamashina-Ku, Kyoto, Japan
raw_author_name: Takayuki Taguchi
raw_affiliation_strings: Drug Research Center, KAKEN PHARMACEUTICAL CO., LTD, 14 Shinomiya Minamigawara-Cho, Yamashina-Ku, Kyoto, Japan
raw_author_name: Koji Bessho
raw_affiliation_strings: Laboratory for Safety Assessment and ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, 632-1, Mifuku, Izunokuni, Shizuoka, Japan
raw_author_name: Daisuke Watanabe
raw_affiliation_strings: PharmaCo-Cell Company Ltd. , Dai-Ichi-Senshu Bldg. 2 Floor, 6-19, Chitose-Machi, Nagasaki, Japan
PharmaCo-Cell Company Ltd.
, Dai-Ichi-Senshu Bldg. 2 Floor, 6-19, Chitose-Machi, Nagasaki, Japan
raw_author_name: Takuo Ogihara
raw_affiliation_strings: Development for Drug Discovery Resources, Department of Medical and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki, Noda, Chiba, 2641, Japan
raw_author_name: Hiroyuki Kusuhara
raw_affiliation_strings: Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku Tokyo, Japan
raw_author_name: Yoshiharu Deguchi
raw_affiliation_strings: Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan. deguchi@pharm.teikyo-u.ac.jp
Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, Japan