Discovery of CZL-077 as a potent, selective, and orally active p300/CBP bromodomain inhibitor with improved in vivo antitumor efficacy
Year: 2025
Type: article
Language: en
Topic: Protein Degradation and Inhibitors
Authors and affiliations:
raw_author_name: Zonglong Chen
raw_affiliation_strings: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China
raw_author_name: Ying Zhang
raw_affiliation_strings: China-New Zealand Joint Laboratory of Biomedicine and Health, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China
School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Lingang Laboratory, Shanghai, 200031, China
raw_author_name: Hui Shen
raw_affiliation_strings: China-New Zealand Joint Laboratory of Biomedicine and Health, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China
raw_author_name: Hong Yang
raw_affiliation_strings: Lingang Laboratory, Shanghai, 200031, China
raw_author_name: Yan Zhang
raw_affiliation_strings: China-New Zealand Joint Laboratory of Biomedicine and Health, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China
School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Lingang Laboratory, Shanghai, 200031, China
raw_author_name: Qiongyu Shi
raw_affiliation_strings: Lingang Laboratory, Shanghai, 200031, China
raw_author_name: Yuxin Yang
raw_affiliation_strings: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China
raw_author_name: Yujie Wang
raw_affiliation_strings: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China
raw_author_name: Ruilin Zhou
raw_affiliation_strings: School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China
raw_author_name: Xiaoxue Tan
raw_affiliation_strings: School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Lingang Laboratory, Shanghai, 200031, China
raw_author_name: Haiyan Wan
raw_affiliation_strings: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China
raw_author_name: Yong Xu
raw_affiliation_strings: China-New Zealand Joint Laboratory of Biomedicine and Health, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Biocomputing, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. Electronic address: xu_yong@gibh.ac.cn
raw_author_name: Xun Huang
raw_affiliation_strings: School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Lingang Laboratory, Shanghai, 200031, China; School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. Electronic address: xhuang@lglab.ac.cn
raw_author_name: Yingxia Li
raw_affiliation_strings: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China. Electronic address: liyx417@fudan.edu.cn