Engineered hemolysin-secreting bacteria enable intracellular bisphosphonate self-assembly to enhance antitumor immunity
Year: 2025
Type: article
Language: en
Topic: Cancer Research and Treatments
Authors and affiliations:
raw_author_name: Long Wang
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Yuchen Wang
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Ruiqi Lei
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Han Wang
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Shengkai Liang
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Yesong Yao
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Chenxuan Zhao
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Xuehui Rui
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China
raw_author_name: Jun Ji
raw_affiliation_strings: Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing 210000, China. Electronic address: jijun@nju.edu.cn
raw_author_name: Jinhui Wu
raw_affiliation_strings: State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China. Electronic address: wuj@nju.edu.cn
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Medical School, Nanjing University, Nanjing 210093, China; Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China; Wuxi Xishan NJU Institute of Applied Biotechnology, Anzhen Street, Xishan District, Wuxi 214101, China; Jiangsu Engineering Center of Biointelligent Materials, Nanjing University, Nanjing 210093, China. Electronic address: wuj@nju.edu.cn