Targeted screening and rational optimization of bazedoxifene analogs as pan-variant SARS-CoV-2 entry inhibitors with improved pharmacokinetics
Year: 2025
Type: article
Language: en
Topic: COVID-19 Clinical Research Studies
Authors and affiliations:
raw_author_name: Binita Patra
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India
raw_author_name: Nirmal Das
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India
raw_author_name: Akshay Joshi
raw_affiliation_strings: CSIR-Institute of Microbial Technology, Ministry of Science & Technology, Sector 39A Rd, 39A, Sector 39, 160036, Chandigarh, India
raw_author_name: Sahil Kumar
raw_affiliation_strings: CSIR-Institute of Microbial Technology, Ministry of Science & Technology, Sector 39A Rd, 39A, Sector 39, 160036, Chandigarh, India
raw_author_name: Renuga Devi
raw_affiliation_strings: CSIR-Center for Cellular and Molecular Biology, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, India
raw_author_name: Biswajit Kundu
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India
raw_author_name: Nanda Kumar Raja
raw_affiliation_strings: Advanced Materials Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai, India, 600020; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
raw_author_name: Israful Hoque
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India
raw_author_name: Soupayan Pal
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India
raw_author_name: Anindita Dey
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India
raw_author_name: Jafar Sarif
raw_affiliation_strings: IICB-Translational Research Unit of Excellence, Department of Cancer Biology and Inflammatory Disorders, CSIR-Indian Institute of Chemical Biology, CN6, Sector V, Salt Lake, Kolkata, 700091, WB, India
raw_author_name: Nittu Singh
raw_affiliation_strings: CSIR-Institute of Microbial Technology, Ministry of Science & Technology, Sector 39A Rd, 39A, Sector 39, 160036, Chandigarh, India
raw_author_name: Nandha Kumaar
raw_affiliation_strings: CSIR-Center for Cellular and Molecular Biology, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, India
raw_author_name: Ravneet Singh Chawla
raw_affiliation_strings: CSIR-Institute of Microbial Technology, Ministry of Science & Technology, Sector 39A Rd, 39A, Sector 39, 160036, Chandigarh, India
raw_author_name: Uddipta Ghosh Dastidar
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
raw_author_name: Alna Kuriyickal Martin
raw_affiliation_strings: CSIR-Center for Cellular and Molecular Biology, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, India
raw_author_name: Kanagasabai Balamurugan
raw_affiliation_strings: Advanced Materials Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai, India, 600020; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
raw_author_name: Bokara Kiran Kumar
raw_affiliation_strings: CSIR-Center for Cellular and Molecular Biology, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
raw_author_name: Rajesh P. Ringe
raw_affiliation_strings: CSIR-Institute of Microbial Technology, Ministry of Science & Technology, Sector 39A Rd, 39A, Sector 39, 160036, Chandigarh, India
raw_author_name: Dipyaman Ganguly
raw_affiliation_strings: IICB-Translational Research Unit of Excellence, Department of Cancer Biology and Inflammatory Disorders, CSIR-Indian Institute of Chemical Biology, CN6, Sector V, Salt Lake, Kolkata, 700091, WB, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
raw_author_name: Krishan Gopal Thakur
raw_affiliation_strings: CSIR-Institute of Microbial Technology, Ministry of Science & Technology, Sector 39A Rd, 39A, Sector 39, 160036, Chandigarh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: krishang@imtech.res.in
raw_author_name: Arindam Talukdar
raw_affiliation_strings: Department of Organic and Medicinal Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, 700032, WB, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: atalukdar.iicb@csir.res.in