PD-1/ PD-L1 bispecific antibody IBI318 combined with lenvatinib in advanced non-small cell lung cancer with acquired resistance to immune checkpoint inhibitors: a phase II trial
Year: 2025
Type: article
Language: en
Topic: Cancer Immunotherapy and Biomarkers
Authors and affiliations:
raw_author_name: Liang Zeng
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Zhaohui Ruan
raw_affiliation_strings: Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China
Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Huan Yan
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
School of Clinical Medicine, Qinghai University, Xining, Qinghai, China
raw_author_name: Haoyue Qin
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Zhen Zeng
raw_affiliation_strings: Department of Thoracic Surgery, Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
raw_author_name: Chun Zou
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Zhe Huang
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Wenjuan Jiang
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Jiacheng Dai
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Shidong Xu
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Lianxi Song
raw_affiliation_strings: Department of Medical Oncology, Yiyang Central Hospital, Yiyang, Hunan, China
raw_author_name: Yangqian Chen
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Yuda Zhang
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
FuRong Laboratory, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
raw_author_name: Fanxu Zeng
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Shiyou Wei
raw_affiliation_strings: Department of Thoracic Surgery, Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
raw_author_name: Shanmei Chen
raw_affiliation_strings: Department of Pathology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Li Liu
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Yi Xiong
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Zhan Wang
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Jun Deng
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Xing Zhang
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Yuanze Sun
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Dan Yang
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Chunhua Zhou
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Haiyan Yang
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Yizhi Li
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Li Deng
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Qinqin Xu
raw_affiliation_strings: Department of Medical Oncology, Qinghai Provincial People's Hospital, Xining, Qinghai, China
raw_author_name: Chao Fang
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Xue Chen
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Jing Wang
raw_affiliation_strings: Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Ting Li
raw_affiliation_strings: Department of Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
raw_author_name: Gao Zhang
raw_affiliation_strings: Faculty of Dentistry, the University of Hong Kong, Hong Kong SAR, China
raw_author_name: Hui Zhou
raw_affiliation_strings: Medical Science and Strategy Oncology, Innovent Biologics (Suzhou) Co. Ltd, Suzhou, Jiangsu, China
raw_author_name: Nong Yang
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. yangnong0217@163.com
Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. yangnong0217@163.com
Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
raw_author_name: Yongchang Zhang
raw_affiliation_strings: Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Early Phase Clinical Trial Center, Department of Investigational Cancer Therapeutics, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
FuRong Laboratory, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China. zhangyongchang@csu.edu.cn
FuRong Laboratory, Changsha, Hunan, China
School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China