Epithelial WNT secretion drives niche escape of developing gastric cancer
Year: 2025
Type: article
Language: en
Topic: Wnt/β-catenin signaling in development and cancer
Authors and affiliations:
raw_author_name: Jaehun Lee
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea. ji-hyun.lee@ibs.re.kr
Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea. ji-hyun.lee@ibs.re.kr
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
raw_author_name: Soomin Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Biology, Kyung Hee University, Seoul, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea
raw_author_name: Youngchul Oh
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
raw_author_name: Stephan R. Jahn
raw_affiliation_strings: Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Jihoon Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea
Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea
raw_author_name: Yeongjun Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Biology, Kyung Hee University, Seoul, Republic of Korea
raw_author_name: Tim Schmäche
raw_affiliation_strings: Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
National Center for Tumor Diseases Dresden(NCT/UCC), a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carusm, Technische Universität Dresden, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
raw_author_name: Sang-Min Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Biology, Kyung Hee University, Seoul, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea
raw_author_name: Isaree Teriyapirom
raw_affiliation_strings: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria
Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna, Austria
raw_author_name: Thomas Groß
raw_affiliation_strings: Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
raw_author_name: Ohbin Kwon
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Graduate School of Stem Cell and Regenerative Biology, KAIST, Daejeon, 34141, Republic of Korea
raw_author_name: Jungmin Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea
Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea
raw_author_name: Somi Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Biology, Kyung Hee University, Seoul, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea
raw_author_name: Anne-Marlen Ada
raw_affiliation_strings: Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Andrea Català-Bordes
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
raw_author_name: Youngwon Cho
raw_affiliation_strings: Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA
Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
raw_author_name: Jinho Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea
Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea
raw_author_name: Amanda Andersson-Rolf
raw_affiliation_strings: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria
raw_author_name: Sebastian R. Merker
raw_affiliation_strings: Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Joo Yeon Lim
raw_affiliation_strings: Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
raw_author_name: Ji-Yeon Park
raw_affiliation_strings: Gradiant Bioconvergence Inc., Seoul, Republic of Korea
raw_author_name: Thomas M. Klompstra
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Graduate School of Stem Cell and Regenerative Biology, KAIST, Daejeon, 34141, Republic of Korea
raw_author_name: Ki-Jun Yoon
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
Graduate School of Stem Cell and Regenerative Biology, KAIST, Daejeon, 34141, Republic of Korea
KAIST Stem Cell Center, KAIST, Daejeon, 34141, Republic of Korea
raw_author_name: Dae-Sik Lim
raw_affiliation_strings: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
KAIST Stem Cell Center, KAIST, Daejeon, 34141, Republic of Korea
raw_author_name: Ho-Seok Lee
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea. leeheetak@ibs.re.kr
Department of Biology, Kyung Hee University, Seoul, Republic of Korea
raw_author_name: Jong Kyoung Kim
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, 13620, Republic of Korea
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea
Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Republic of Korea
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
Precision Medicine Center, Future Innovation Research Division, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeonggi-do, 13620, Republic of Korea
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea
raw_author_name: Eunyoung Choi
raw_affiliation_strings: Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA
Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA
Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
raw_author_name: James R. Goldenring
raw_affiliation_strings: Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA
Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA
Nashville VA Medical Center, Nashville, TN, USA
Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
raw_author_name: Jae-Ho Cheong
raw_affiliation_strings: Chronic Intractable Disease for Systems Medicine Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea. jhcheong@yuhs.ac
Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Republic of Korea. jhcheong@yuhs.ac
Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea. jhcheong@yuhs.ac
Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea. jhcheong@yuhs.ac
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. jhcheong@yuhs.ac
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. jhcheong@yuhs.ac
raw_author_name: Hyunki Kim
raw_affiliation_strings: Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea. kimhyunki@yuhs.ac
raw_author_name: Daniel E. Stange
raw_affiliation_strings: Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. daniel.stange@ukdd.de
German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Dresden, Germany. daniel.stange@ukdd.de
National Center for Tumor Diseases Dresden(NCT/UCC), a Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carusm, Technische Universität Dresden, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany. daniel.stange@ukdd.de
raw_author_name: Heetak Lee
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea. leeheetak@ibs.re.kr
Department of Biology, Kyung Hee University, Seoul, Republic of Korea
raw_author_name: Bon-Kyoung Koo
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea. koobk@ibs.re.kr
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. koobk@ibs.re.kr
Graduate School of Stem Cell and Regenerative Biology, KAIST, Daejeon, 34141, Republic of Korea. koobk@ibs.re.kr
raw_author_name: Ji-Hyun Lee
raw_affiliation_strings: Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea
Center for Genome Engineering, Institute for Basic Sciences, Daejeon, Republic of Korea. ji-hyun.lee@ibs.re.kr
Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea. ji-hyun.lee@ibs.re.kr
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea