Sonic hedgehog inhibitor suppresses carcinoma associated fibroblasts to prime Gemcitabine/Nab-Paclitaxel and anti-CTLA4 immunotherapy as sequential first-line combination therapy in a Phase 1b/2 study in PDAC: NUMANTIA trial
Year: 2025
Type: article
Topic: Hedgehog Signaling Pathway Studies
Authors and affiliations:
raw_author_name: Valerie S. Kalluri
raw_affiliation_strings: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
raw_author_name: Bruno Bockorny
raw_affiliation_strings: Gastroenterology Medical Oncology, Beth Israel Deaconess Medical Center, Boston, USA;
Gastroenterology Medical Oncology, Beth Israel Deaconess Medical Center, Boston, USA
raw_author_name: Evelio Perea Borobio
raw_affiliation_strings: Nelum Corp, Cary, NC, USA;
Nelum Corp, Cary, NC, USA
raw_author_name: Teresa Macarulla
raw_affiliation_strings: University Hospital, Vall D'Hebro Institute of Oncology, Barcelona, Spain;
University Hospital, Vall D'Hebro Institute of Oncology, Barcelona, Spain
raw_author_name: Roberto Pazo Cid
raw_affiliation_strings: Hospital Universitario Miguel Servet, Zaragoza, Spain;
Hospital Universitario Miguel Servet, Zaragoza, Spain
raw_author_name: Laura Medina
raw_affiliation_strings: Department of Medical Oncology, Hospital Universitario Virgen de la Victoria, Malaga, Spain;
Department of Medical Oncology, Hospital Universitario Virgen de la Victoria, Malaga, Spain
raw_author_name: Aitziber Gil-Negrete
raw_affiliation_strings: Hospital Universitario de Donostia, Gipuzkoa, Spain;
Hospital Universitario de Donostia, Gipuzkoa, Spain
raw_author_name: Fernando Rivera
raw_affiliation_strings: Hospital Universitario Marques de Valdecilla, Santander, Spain;
Hospital Universitario Marques de Valdecilla, Santander, Spain
raw_author_name: Vanesa Varela
raw_affiliation_strings: Complexo Hospitalario de Santiago de Compostela, Galicia, Spain;
Complexo Hospitalario de Santiago de Compostela, Galicia, Spain
raw_author_name: Alejandro Martin-Munoz
raw_affiliation_strings: Altum Sequencing, Madrid, Spain;
Altum Sequencing, Madrid, Spain
raw_author_name: Yanira Ruiz-Heredia
raw_affiliation_strings: Altum Sequencing, Madrid, Spain;
Altum Sequencing, Madrid, Spain
raw_author_name: Bingrui Li
raw_affiliation_strings: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
raw_author_name: Patience Kelly
raw_affiliation_strings: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
raw_author_name: Barbara Moreno Diaz
raw_affiliation_strings: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
raw_author_name: Shreyasee V Kumbar
raw_affiliation_strings: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
raw_author_name: Hikaru Sugimoto
raw_affiliation_strings: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
raw_author_name: Raghu Kalluri
raw_affiliation_strings: Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA;
Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA
raw_author_name: Manuel Hidalgo
raw_affiliation_strings: Gastrointestinal Cancer Center, Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, TX USA