A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway
Year: 2025
Type: article
Language: en
Topic: Pancreatic and Hepatic Oncology Research
Authors and affiliations:
raw_author_name: Motoyuki Tsuda
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Dove Keith
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Colin J. Daniel
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Carl Pelz
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Katie E. Blise
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Tugba Y. Ozmen
raw_affiliation_strings: Division of Oncological Sciences, Knight Cancer Institute, OHSU;
Division of Oncological Sciences, Knight Cancer Institute, OHSU
raw_author_name: Furkan Ozmen
raw_affiliation_strings: Division of Oncological Sciences, Knight Cancer Institute, OHSU;
Division of Oncological Sciences, Knight Cancer Institute, OHSU
raw_author_name: Kevin Hawthone
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Jennifer R. Eng
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Xi Li
raw_affiliation_strings: Division of Oncological Sciences, Knight Cancer Institute, OHSU;
Division of Oncological Sciences, Knight Cancer Institute, OHSU
raw_author_name: Xiaoyan Wang
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Hayley Zimny
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Shamilene Sivagnanam
raw_affiliation_strings: Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU;
Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU
raw_author_name: Konjit Betre
raw_affiliation_strings: Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU;
Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU
raw_author_name: Nell Kirchberger
raw_affiliation_strings: Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU;
Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU
raw_author_name: Benson Chong
raw_affiliation_strings: Knight Cancer Institute, OHSU;
Knight Cancer Institute, OHSU
raw_author_name: Jinho Lee
raw_affiliation_strings: Knight Cancer Institute, OHSU;
Knight Cancer Institute, OHSU
raw_author_name: Aubry Matter
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Alexander Smith
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Ethan S. Agritelley
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Trent Waugh
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Ashwin Sannecy
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Kimberly Alarcon
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Isaac Youm
raw_affiliation_strings: Knight Cancer Institute, OHSU;
Knight Cancer Institute, OHSU
raw_author_name: Sara Protzek
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Julian Egger
raw_affiliation_strings: Department of Biomedical Engineering, OHSU;
Department of Biomedical Engineering, OHSU
raw_author_name: Isabel A. English
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Min Yang
raw_affiliation_strings: Department of Biomedical Engineering, OHSU;
Department of Biomedical Engineering, OHSU
raw_author_name: Vidhi M. Shah
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA
raw_author_name: Jason M. Link
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Allison L. Creason
raw_affiliation_strings: Department of Biomedical Engineering, OHSU;
Department of Biomedical Engineering, OHSU
raw_author_name: Patrick J. Worth
raw_affiliation_strings: Dept. of Surgery, Department of Medicine, OHSU;
Dept. of Surgery, Department of Medicine, OHSU
raw_author_name: Shaun M. Goodyear
raw_affiliation_strings: Division of Hematology and Medical Oncology, Department of Medicine, OHSU;
Division of Hematology and Medical Oncology, Department of Medicine, OHSU
raw_author_name: Koei Chin
raw_affiliation_strings: Knight Cancer Institute, OHSU;
Knight Cancer Institute, OHSU
raw_author_name: John L. Muschler
raw_affiliation_strings: Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU;
Brenden-Colson Center for Pancreatic Care, Knight Cancer Institute, OHSU
raw_author_name: Christopher G. Suciu
raw_affiliation_strings: Department of Pathology & Laboratory Medicine, Department of Medicine, OHSU;
Department of Pathology & Laboratory Medicine, Department of Medicine, OHSU
raw_author_name: Christopher L. Corless
raw_affiliation_strings: Department of Pathology & Laboratory Medicine, Department of Medicine, OHSU;
Department of Pathology & Laboratory Medicine, Department of Medicine, OHSU
raw_author_name: Sha Cao
raw_affiliation_strings: Department of Biomedical Engineering, OHSU;
Department of Biomedical Engineering, OHSU
raw_author_name: Laura Soucek
raw_affiliation_strings: Vall d'Hebron Institute of Oncology, Barcelona, Spain
raw_author_name: Adel Kardosh
raw_affiliation_strings: Division of Hematology and Medical Oncology, Department of Medicine, OHSU;
Division of Hematology and Medical Oncology, Department of Medicine, OHSU
raw_author_name: Lisa M. Coussens
raw_affiliation_strings: Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU;
Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, OHSU
raw_author_name: Jonathan R. Brody
raw_affiliation_strings: Dept. of Surgery, Department of Medicine, OHSU;
Dept. of Surgery, Department of Medicine, OHSU
raw_author_name: Charles D. Lopez
raw_affiliation_strings: Division of Hematology and Medical Oncology, Department of Medicine, OHSU;
Division of Hematology and Medical Oncology, Department of Medicine, OHSU
raw_author_name: Gordon B. Mills
raw_affiliation_strings: Division of Oncological Sciences, Knight Cancer Institute, OHSU;
Division of Oncological Sciences, Knight Cancer Institute, OHSU
raw_author_name: Rosalie C. Sears
raw_affiliation_strings: Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA;
Dept. of Molecular and Medical Genetics, Oregon Health & Science University (OHSU), Portland, USA