A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies
Year: 2025
Type: article
Language: en
Topic: PI3K/AKT/mTOR signaling in cancer
Authors and affiliations:
raw_author_name: Fan He
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Shuyang Lin
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Bei Gao
raw_affiliation_strings: Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA
raw_author_name: Varun Ramesh
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Alexander B. Kim
raw_affiliation_strings: Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA
raw_author_name: Tim Kong
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Daniel A. C. Fisher
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Christopher T. Letson
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Molly Brakhane
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Mary Fulbright
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA
raw_author_name: Yanbo Yu
raw_affiliation_strings: Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA
raw_author_name: Marco Sardiello
raw_affiliation_strings: Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA
raw_author_name: Jorge Di Paola
raw_affiliation_strings: Department of Pediatrics, Division of Hematology & Oncology, School of Medicine, Washington University School of Medicine, St. Louis, MO, USA
raw_author_name: Stephen M. Sykes
raw_affiliation_strings: Department of Pediatrics, Division of Hematology & Oncology, School of Medicine, Washington University School of Medicine, St. Louis, MO, USA
raw_author_name: Stephen T. Oh
raw_affiliation_strings: Department of Medicine, Division of Hematology, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Ave, St. Louis, MO, 63110, USA. stoh@wustl.edu
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. stoh@wustl.edu
Immunomonitoring Laboratory, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. stoh@wustl.edu
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA