Reversal of auditory cortical hyperexcitability and restoration of synaptic plasticity balance by GluN1-mediated photobiomodulation in noise-induced tinnitus
Year: 2025
Type: article
Language: en
Topic: Hearing, Cochlea, Tinnitus, Genetics
Authors and affiliations:
raw_author_name: Zhixin Zhang
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China. Electronic address: zhangzhixin0246@126.com
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China. Electronic address: zhangzhixin0246@126.com
raw_author_name: Xinmiao Xue
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
raw_author_name: Dongdong He
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
raw_author_name: Peng Liu
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Departments of Otorhinolaryngology-Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang 050081, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Departments of Otorhinolaryngology-Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang 050081, China
raw_author_name: Chi Zhang
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
raw_author_name: Yvke Jiang
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
raw_author_name: Shuhan Lv
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
raw_author_name: Li Wang
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China; Graduate School of Medicine, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China
raw_author_name: Hanwen Zhou
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
raw_author_name: Weidong Shen
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China
raw_author_name: Shiming Yang
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China. Electronic address: shm_yang@163.com
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China. Electronic address: shm_yang@163.com
raw_author_name: Fangyuan Wang
raw_affiliation_strings: Senior Department of Otolaryngology Head and Neck Surgery, The sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China. Electronic address: fangyuanwang05@163.com
Senior Department of Otolaryngology Head and Neck Surgery,, the sixth of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China; State Key Laboratory of Hearing and Balance Science, Beijing 100853, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing 100853, China; Key Laboratory of Hearing Science, Ministry of Education, Beijing 100853, China; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing 100853, China. Electronic address: fangyuanwang05@163.com