Benchmarking progression-free survival ratio as primary endpoint in precision oncology clinical trials
Year: 2025
Type: article
Language: en
Topic: Statistical Methods in Clinical Trials
Authors and affiliations:
raw_author_name: Federico Nichetti
raw_affiliation_strings: Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany. federico.nichetti@iov.veneto.it
Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. federico.nichetti@iov.veneto.it
Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy
raw_author_name: Jennifer Hüllein
raw_affiliation_strings: Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Pauline du Rusquec
raw_affiliation_strings: Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France
INSERM U900 Research unit, Institut Curie, Saint-Cloud, France
raw_author_name: Erin Pleasance
raw_affiliation_strings: Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada
raw_author_name: Li Chen
raw_affiliation_strings: Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA
Markey Cancer Center, University of Kentucky, Lexington, KY, USA
raw_author_name: Andreas Mock
raw_affiliation_strings: Institute of Pathology, University of Munich (LMU), Munich, Germany
raw_author_name: Peter Horak
raw_affiliation_strings: Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany
German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Paolo Ambrosini
raw_affiliation_strings: Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
raw_author_name: Simone Rota
raw_affiliation_strings: Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
raw_author_name: Monica Niger
raw_affiliation_strings: Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
raw_author_name: Luca Agnelli
raw_affiliation_strings: Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
raw_author_name: Gabriele Tinè
raw_affiliation_strings: Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy
raw_author_name: Dominic Edelmann
raw_affiliation_strings: Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
NCT Trial Center, National Center for Tumor Diseases, Heidelberg, Germany
raw_author_name: Christophe Le Tourneau
raw_affiliation_strings: Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France
INSERM U900 Research unit, Institut Curie, Saint-Cloud, France
Paris-Saclay University, Paris, France
raw_author_name: Janessa Laskin
raw_affiliation_strings: Department of Medical Oncology, BC Cancer, Vancouver, BC, Canada
raw_author_name: Giancarlo Pruneri
raw_affiliation_strings: Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
raw_author_name: Chi Wang
raw_affiliation_strings: Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA
Markey Cancer Center, University of Kentucky, Lexington, KY, USA
raw_author_name: Daniel Hübschmann
raw_affiliation_strings: Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany
German Cancer Consortium (DKTK), Heidelberg, Germany
Pattern Recognition and Digital Medicine Group, Heidelberg Institute for Stem cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany
raw_author_name: Filippo de Braud
raw_affiliation_strings: Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy
raw_author_name: Stefan Fröhling
raw_affiliation_strings: Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany
German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Luigi Mariani
raw_affiliation_strings: Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy