Design and Optimization of LOXL2 and sGC Dual-Target Regulators Targeting Extracellular Matrix Dysregulation and Vasodilation for the Treatment of Pulmonary Arterial Hypertension
Year: 2025
Type: article
Language: en
Topic: Pulmonary Hypertension Research and Treatments
Authors and affiliations:
raw_author_name: Yuanbo Hu
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
raw_author_name: Yu Wang
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
raw_author_name: Wenhua Tan
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
raw_author_name: Congke Zhao
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
raw_author_name: Mengqi Li
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
raw_author_name: Sufang Xiang
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
raw_author_name: Xinru Liang
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
raw_author_name: Ruizhe Gao
raw_affiliation_strings: Hunan Normal University
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Pharmaceutical Sciences
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Pharmaceutical Sciences, Hunan Normal University, Changsha, Hunan 410013, China
raw_author_name: Bin Zeng
raw_affiliation_strings: Hunan Normal University
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Pharmaceutical Sciences
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Pharmaceutical Sciences, Hunan Normal University, Changsha, Hunan 410013, China
raw_author_name: Zhuo Chen
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
raw_author_name: Liqing Hu
raw_affiliation_strings: Hunan Normal University
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Pharmaceutical Sciences
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Pharmaceutical Sciences, Hunan Normal University, Changsha, Hunan 410013, China
raw_author_name: Qianbin Li
raw_affiliation_strings: Central South University
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases
Hunan Key Laboratory of Organ Fibrosis
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha, Hunan 410013, China
Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan 410013, China
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China