Discovery of Imidazo[1,2- <i>b</i> ]pyridazine Derivatives as Potent PI3K/mTOR Dual Inhibitors for the Treatment of Pulmonary Fibrosis
Year: 2025
Type: article
Language: en
Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Authors and affiliations:
raw_author_name: Wanjing Zeng
raw_affiliation_strings: East China Normal University
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
raw_author_name: Xiaoyuan Hua
raw_affiliation_strings: East China Normal University
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
raw_author_name: Zhengyang Wang
raw_affiliation_strings: East China Normal University
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
raw_author_name: Kaiyin Li
raw_affiliation_strings: East China Normal University
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
raw_author_name: Ying Yin
raw_affiliation_strings: East China Normal University
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
raw_author_name: Xu-wen Li
raw_affiliation_strings: Bohai Rim Advanced Research Institute for Drug Discovery
Shandong Laboratory of Yantai Drug Discovery
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
State Key Laboratory of Chemical Biology
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China
State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
raw_author_name: Suzhen Dong
raw_affiliation_strings: East China Normal University
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
raw_author_name: Mingliang Ma
raw_affiliation_strings: East China Normal University
Key Laboratory of Brain Functional Genomics-Ministry of Education, School of Life Science
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China