A predictive model for life-threatening fluoropyrimidine toxicity based on <i>DPYD</i> sequencing in colorectal cancer
Year: 2025
Type: article
Language: en
Topic: Colorectal Cancer Treatments and Studies
Authors and affiliations:
raw_author_name: Valérie Boige
raw_affiliation_strings: Centre de Recherche des Cordeliers, INSERM UMRS-1138, Sorbonne Université, Université Paris Cité , Paris,
Department of Cancer Medicine, Gustave Roussy , Villejuif,
Université Paris Cité Department of Cancer Medicine, , Villejuif, France; Centre de Recherche des Cordeliers, , , , Paris,
INSERM UMRS-1138 Department of Cancer Medicine, , Villejuif, France; Centre de Recherche des Cordeliers, , , , Paris,
raw_author_name: Estelle Menoret
raw_affiliation_strings: INSERM 1263, INRAE 1260, C2VN, Aix Marseille University (AMU) , Marseille,
Aix Marseille University (AMU) - INSERM 1263, Marseille, INRAE 1260, C2VN, France
raw_author_name: Gwénaël Le Teuff
raw_affiliation_strings: Department of Biostatistics and Epidemiology, Gustave Roussy, University Paris-Saclay , Villejuif,
Oncostat U1018, Inserm, University Paris-Saclay, labeled Ligue Contre le Cancer , Villejuif,
University Paris-Saclay, labeled Ligue Contre le Cancer Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
Gustave Roussy Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
University Paris-Saclay Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
raw_author_name: Jean-Christophe Boyer
raw_affiliation_strings: Service de Biochimie et Biologie Moléculaire, CHU Carémeau , Nîmes,
CHU Carémeau Service de Biochimie et Biologie Moléculaire, , Nîmes,
raw_author_name: Nathalie Cozic
raw_affiliation_strings: Department of Biostatistics and Epidemiology, Gustave Roussy, University Paris-Saclay , Villejuif,
Oncostat U1018, Inserm, University Paris-Saclay, labeled Ligue Contre le Cancer , Villejuif,
University Paris-Saclay Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
University Paris-Saclay, labeled Ligue Contre le Cancer Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
Gustave Roussy Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
raw_author_name: Jean-Pierre Desvignes
raw_affiliation_strings: INSERM 1263, INRAE 1260, C2VN, Aix Marseille University (AMU) , Marseille,
Aix Marseille University (AMU) - INSERM 1263, Marseille, INRAE 1260, C2VN, France
raw_author_name: Julien Taieb
raw_affiliation_strings: Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096 , Paris,
Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Hopital européen Georges Pompidou , Paris,
CNRS SNC 5096 Centre de Recherche des Cordeliers, INSERM, , , Paris,
Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer Centre de Recherche des Cordeliers, INSERM, , , Paris,
raw_author_name: Pierre Laurent-Puig
raw_affiliation_strings: Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096 , Paris,
Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Hopital européen Georges Pompidou , Paris,
CNRS SNC 5096 Centre de Recherche des Cordeliers, INSERM, , , Paris,
Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer Centre de Recherche des Cordeliers, INSERM, , , Paris,
raw_author_name: Yvonne Wettergren
raw_affiliation_strings: Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg,
Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital , Gothenburg,
and Region Västra Götaland Department of Surgery, Institute of Clinical Sciences, , , Gothenburg, Sweden; , , Department of Surgery, Gothenburg,
Sahlgrenska University Hospital Department of Surgery, Institute of Clinical Sciences, , , Gothenburg, Sweden; , , Department of Surgery, Gothenburg,
raw_author_name: Matthias Schwab
raw_affiliation_strings: Cluster of Excellence iFIT (EXC2180) “Image–guided and Functionally Instructed Tumor Therapies”, University of Tübingen , Tübingen,
Department of Biochemistry and Pharmacy, University of Tuebingen , Tuebingen,
Department of Clinical Pharmacology, Dr. Margarete Fischer-Bosch-Institute , Stuttgart,
Department of Clinical Pharmacology, University of Tuebingen , Tuebingen,
University of Tübingen , Stuttgart, Germany; and Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, , Tuebingen, Germany; and Cluster of Excellence iFIT (EXC2180) “Image-­guided and Functionally Instructed Tumor Therapies”, , Tübingen,
Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology , Stuttgart, Germany; and Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, , Tuebingen, Germany; and Cluster of Excellence iFIT (EXC2180) “Image-­guided and Functionally Instructed Tumor Therapies”, , Tübingen,
University of Tuebingen , Stuttgart, Germany; and Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, , Tuebingen, Germany; and Cluster of Excellence iFIT (EXC2180) “Image-­guided and Functionally Instructed Tumor Therapies”, , Tübingen,
raw_author_name: Stephen Ackland
raw_affiliation_strings: College of Heath, Medicine and Wellbeing, University of Newcastle , Newcastle,
College of Heath, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia
raw_author_name: Barbara Jennings
raw_affiliation_strings: Norwich Medical School, University of East Anglia , Norwich,
Norwich Medical School, University of East Anglia, Norwich, United Kingdom
raw_author_name: Anne Sudaka
raw_affiliation_strings: Biological Ressource Center, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
Department of Clinical Research and Innovation, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
Université Côte d’Azur Department of Clinical Research and Innovation, Centre Antoine Lacassagne, , Nice,
raw_author_name: Eva Seutin
raw_affiliation_strings: Biological Ressource Center, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
Department of Clinical Research and Innovation, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
Université Côte d’Azur Department of Clinical Research and Innovation, Centre Antoine Lacassagne, , Nice,
raw_author_name: Christophe Beroud
raw_affiliation_strings: INSERM 1263, INRAE 1260, C2VN, Aix Marseille University (AMU) , Marseille,
Aix Marseille University (AMU) - INSERM 1263, Marseille, INRAE 1260, C2VN, France
raw_author_name: Yves Koudou
raw_affiliation_strings: Department of Biostatistics and Epidemiology, Gustave Roussy, University Paris-Saclay , Villejuif,
Oncostat U1018, Inserm, University Paris-Saclay, labeled Ligue Contre le Cancer , Villejuif,
Gustave Roussy Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
University Paris-Saclay, labeled Ligue Contre le Cancer Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
University Paris-Saclay Department of Biostatistics and Epidemiology, , , Villejuif, France; Oncostat U1018, Inserm, , Villejuif,
raw_author_name: Marie-Christine Etienne-Grimaldi
raw_affiliation_strings: Laboratory of Translational Research in Oncology (LRTO), Université Côte d’Azur , Nice,
Oncopharmacology Department, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
Laboratory of Translational Research in Oncology (LRTO) , , Nice,
Université Côte d’Azur Oncopharmacology Department, Centre Antoine Lacassagne, , Nice,
Université Côte d’Azur , , Nice,
raw_author_name: FUSAFE-2 (Fluoropyrimidine Safe-2) Collaborative Group
raw_author_name: Stephen Ackland
raw_affiliation_strings: College of Heath, Medicine and Wellbeing, University of Newcastle , Newcastle,
raw_author_name: Valérie Boige
raw_affiliation_strings: Centre de Recherche des Cordeliers, INSERM UMRS-1138, Sorbonne Université, Université Paris Cité , Paris,
Department of Cancer Medicine, Gustave Roussy , Villejuif,
raw_author_name: Jean-Christophe Boyer
raw_affiliation_strings: Service de Biochimie et Biologie Moléculaire, CHU Carémeau , Nîmes,
raw_author_name: Barna Budai
raw_author_name: Jean-Pierre Desvignes
raw_affiliation_strings: INSERM 1263, INRAE 1260, C2VN, Aix Marseille University (AMU) , Marseille,
raw_author_name: Antonello Di Paolo
raw_author_name: Barbara A Jennings
raw_affiliation_strings: Norwich Medical School, University of East Anglia , Norwich,
raw_author_name: Pierre Laurent-Puig
raw_affiliation_strings: Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096 , Paris,
Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Hopital européen Georges Pompidou , Paris,
raw_author_name: Antony Marinaki
raw_author_name: Estelle Menoret
raw_affiliation_strings: INSERM 1263, INRAE 1260, C2VN, Aix Marseille University (AMU) , Marseille,
raw_author_name: Matthias Schwab
raw_affiliation_strings: Cluster of Excellence iFIT (EXC2180) “Image–guided and Functionally Instructed Tumor Therapies”, University of Tübingen , Tübingen,
Department of Biochemistry and Pharmacy, University of Tuebingen , Tuebingen,
Department of Clinical Pharmacology, Dr. Margarete Fischer-Bosch-Institute , Stuttgart,
Department of Clinical Pharmacology, University of Tuebingen , Tuebingen,
raw_author_name: Eva Seutin
raw_affiliation_strings: Biological Ressource Center, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
Department of Clinical Research and Innovation, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
raw_author_name: Anne Sudaka
raw_affiliation_strings: Biological Ressource Center, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
Department of Clinical Research and Innovation, Centre Antoine Lacassagne, Université Côte d’Azur , Nice,
raw_author_name: Julien Taieb
raw_affiliation_strings: Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096 , Paris,
Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Hopital européen Georges Pompidou , Paris,
raw_author_name: Yvonne Wettergren
raw_affiliation_strings: Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg,
Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital , Gothenburg,
raw_author_name: Göran Carlsson
raw_author_name: Ulrich M Zanger