Protein-nucleic acid language model-assisted design of precise and compact adenine base editor
Year: 2025
Type: article
Language: en
Topic: CRISPR and Genetic Engineering
Authors and affiliations:
raw_author_name: Jingxuan Ren
raw_affiliation_strings: State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
raw_author_name: Jiawei Yao
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
raw_author_name: Qiuyu Cao
raw_affiliation_strings: State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
raw_author_name: Yinuo Li
raw_affiliation_strings: Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
raw_author_name: Yang Li
raw_affiliation_strings: Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
raw_author_name: Ziyi Zhang
raw_affiliation_strings: State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
raw_author_name: Xiyu Ge
raw_affiliation_strings: Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA
raw_author_name: Shengfang Wang
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
raw_author_name: Yang Zhang
raw_affiliation_strings: Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. zhang@nus.edu.sg
State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China. zhang@nus.edu.sg
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
raw_author_name: Xiaogang Wang
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. xiaogangwang@smu.edu.cn
Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
raw_author_name: Xiaohui Zhang
raw_affiliation_strings: State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China. zhangxiaohui3040@126.com
State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China