LabID-base/OpenAlex-Afillation huggingface dataset:
Variations in Platelet Count Associated with the Occurrence of Infected Pancreatic Necrosis, Surgical Intervention, and Mortality in Acute Pancreatitis: A Retrospective Cohort Study
Year: 2025
Type: article
Language: en
Topic: Pancreatitis Pathology and Treatment
Authors and affiliations:
raw_author_name: Wenwu Sun
raw_affiliation_strings: Department of Emergency Medicine, Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, People's Republic of China
Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
raw_author_name: Bing Zhao
raw_affiliation_strings: Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
raw_author_name: Zhiyuan Wang
raw_affiliation_strings: Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
raw_author_name: Enqiang Mao
raw_affiliation_strings: Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
raw_author_name: Yang Li
raw_affiliation_strings: Department of Emergency Medicine, Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, People's Republic of China
raw_author_name: Zaiqian Che
raw_affiliation_strings: Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
Quantifying responsibility for cross-state air pollution: an airshed approach
Year: 2025
Type: article
Language: en
Topic: Air Quality and Health Impacts
Authors and affiliations:
raw_author_name: Wenxu Liao
raw_affiliation_strings: Civil and Environmental Engineering and Earth Sciences Department, University of Notre Dame, Notre Dame, IN, United States of America
raw_author_name: Richard Marcantonio
raw_affiliation_strings: Kroc Institute for International Peace Studies in the Keough School of Global Affairs, University of Notre Dame, Notre Dame, IN, United States of America
raw_author_name: Paola Crippa
raw_affiliation_strings: Civil and Environmental Engineering and Earth Sciences Department, University of Notre Dame, Notre Dame, IN, United States of America
MODULATION OF EXTRACELLULAR SIGNAL-RELATED KINASE, CYCLIN D1, GLIAL FIBRILLARY ACIDIC PROTEIN, AND VIMENTIN EXPRESSION IN ESTRADIOL-PRETREATED ASTROCYTE CULTURES TREATED WITH COMPETENCE AND PROGRESSION GROWTH FACTORS
Year: 2025
Type: article
Language: en
Topic: Growth Hormone and Insulin-like Growth Factors
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: The present study seeks to elucidate the interactions between the “competence” growth factor basic fibroblast growth factor (bFGF) and/or estrogen 17b-estradiol and the “progression” growth factors epidermal growth factor (EGF), insulin-like growth factor-I (IGFI), and insulin (INS) on DNA labeling and also cyclin D1, extracellular signal- related kinase 1/2 (ERK1/2), glial fibrillary acidic protein (GFAP), and vimentin expression in astroglial cultures under different experimental conditions. Pretreatment for 24 hr with bFGF and subsequent exposure for 36 hr to estradiol (E2) and EGF, IGF-I, or INS stimulated DNA labeling in the last 12 hr, especially when the cultures were treated with progression growth factors. bFGF pretreatment and subsequent treatment with E2 for 36 hr stimulated DNA labeling. The 36-hr E2 treatment alone did not significantly decrease DNA labeling, but contemporary addition of E2 with two or three growth factors stimulated DNA labeling remarkably. When E2 was coadded with growth factors, a significantly increased DNA labeling was observed, demonstrating an astroglial synergistic mitogenic effect evoked by contemporary treatment with growth factors in the presence of estrogens. Cyclin D1 expression was markedly increased when astrocyte cultures were pretreated for 36 hr with E2 and subsequently treated with two or three competence and progression growth factors. A highly significant increase of ERK1/2 expression was observed after all the treatments (EGF, bFGF, INS, IGF-I alone or in combination with two or three growth factors). GFAP and vimentin expression was markedly increased when the cultures were treated with two or three growth factors. In conclusion, our data demonstrate estradiol growth factor crosstalk during astroglial cell proliferation and differentiation in culture
Huella de carbono de la facultad de Ciencias Forestales, Universidad Nacional de Santiago del Estero
Year: 2025
Type: article
Topic: Public Health and Environmental Issues
Authors and affiliations:
raw_author_name: Luana Lucía Prados
raw_affiliation_strings: Universidad Nacional de Santiago del Estero, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
raw_author_name: Gabriela Giuliano
raw_affiliation_strings: Universidad Nacional de Santiago del Estero, Comisión Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
raw_author_name: Beatriz Garzón
raw_affiliation_strings: Universidad Nacional de Tucumán, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
INVESTIGATION OF STRUCTURAL PRESERVATION OF PERIPHERAL NERVE EXTRACELLULAR MATRIX FOLLOWING &lt;i&gt;EX VIVO&lt;/i&gt; LIMB PERFUSION
Year: 2025
Type: article
Language: en
Topic: Nerve injury and regeneration
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Peripheral nerve injuries (PNI) represent a significant clinical challenge, frequently resulting in permanent sensory and motor defects. Traumatic injuries can severely alter the peripheral nerve’s extracellular matrix (ECM), which is fundamental in guiding Schwann cell (SC) and neuronal responses during regeneration. Given its importance, there is growing interest in understanding how traumatic injuries (amputations) and post-lesion treatments, such as ex vivo perfusion, affect ECM structure and composition. The study aims to evaluate ECM integrity following traumatic injury of peripheral nerves and post-lesion treatment. Amputated porcine limbs were perfused ex vivo with Perfadex® solution for 6 h, after which tibial and common fibular nerves were harvested. ECM components were analyzed using histological stainings: Wallart and Houette’s Trichrome for collagen, Verhoeff’s Van Gieson for elastin, and Alcian blue for glycosaminoglycans. Laminin and fibronectin distribution were assessed by immunofluorescence and ultrastructural features were examined by transmission electron microscopy (TEM). This work is expected to provide insights into ECM remodeling after peripheral nerve trauma and to clarify whether ex vivo perfusion contributes to preserving its structural and molecular organization. Such knowledge may support the development of improved strategies for peripheral nerve repair
Review of road selection methods for purpose of multiscale mapping
Year: 2025
Type: article
Language: en
Topic: Wildlife-Road Interactions and Conservation
Authors and affiliations:
raw_author_name: Albert Adolf
raw_affiliation_strings: Faculty of Geography and Regional Studies, University of Warsaw, Warsaw, Poland
raw_author_name: Izabela Karsznia
raw_affiliation_strings: Faculty of Geography and Regional Studies, University of Warsaw, Warsaw, Poland
Does micronutrient supplementation improve outcomes in adult gastrointestinal surgery patients? A systematic review
Year: 2025
Type: article
Language: en
Topic: Nutrition and Health in Aging
Authors and affiliations:
raw_author_name: Daoud Salman
raw_affiliation_strings: Faculty of Medicine, School of Human Development and Health, University of Southampton, Southampton, United Kingdom
raw_author_name: Trevor Smith
raw_affiliation_strings: University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
raw_author_name: Philip C. Calder
raw_affiliation_strings: Faculty of Medicine, School of Human Development and Health, University of Southampton, Southampton, United Kingdom
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom
THERAPEUTIC &lt;i&gt;VERSUS&lt;/i&gt; PREVENTIVE ADMINISTRATION OF NEUROACTIVE STEROIDS TO TREAT BORTEZOMIB-INDUCED PAINFUL NEUROPATHY
Year: 2025
Type: article
Language: en
Topic: Cancer Treatment and Pharmacology
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling condition resulting from antineoplastic treatment. The proteasome inhibitor bortezomib (BTZ) can cause painful peripheral neuropathy (BIPN) with a negative impact on cancer survivors’ quality of life. Although reducing pain is often a main focus of BIPN treatment, remarkably few analgesics have been tested. A growing number of reports suggest that CIPN can be attenuated by the concomitant use of neuroactive steroids (NAS), cholesterol derivatives with proven neuroprotective effects in several in vivo models of peripheral neuropathy. However, an important factor in the development of neuroprotective intervention is whether to adopt a therapeutic or a preventive approach. Therefore, we tested the analgesic effect of two NAS, allopregnanolone (ALLO) and pregnenolone (PREG), in two rodent models of BIPN. Female Wistar rats were intravenously treated with BTZ (0.2 mg/kg, 3qw) for 4 weeks. To study the therapeutic effect, co-administrations of BTZ and ALLO (3 mg/kg/every 2 days) or PREG (6 mg/kg/every 2 days) were performed subcutaneously for another 4 weeks. Instead, in the preventive schedule, ALLO or PREG were coadministered for 4 weeks with BTZ from the beginning of the study. Here, we tested the protective effects of the two NAS using a battery of behavioral and neurophysiological tests as well as morphological and morphometrical analyses of myelinated nerves and intraepidermal small unmyelinated fibers (IENF) densities. Treatment with BTZ induced significant mechanical allodynia and thermal hyperalgesia, as well as a reduction of sensory action potential amplitude in peripheral nerves already at 4 weeks, with severe neuropathic symptoms at 8 weeks. NAS administration alleviated BTZ-induced behavioral alterations and partially prevented neurophysiological symptoms. In addition, BTZ treatment induced a significant loss of both myelinated and unmyelinated fibers in the caudal nerves and skin, respectively. A protective effect was observed after NAS treatment on IENF. Taken together, our results suggest that since NAS counteracted painful symptoms induced by BTZ, they could be used to alleviate BIPN neurotoxic manifestations. Moreover, having knowledge of the precise timing of therapeutic intervention is paramount to boost any neuroprotective treatment efficacy. This research has received funding from EU in NextGenerationEU plan through the Italian “Bando Prin 2022D.D. 1409 del 14-09-2022”
Experimental Investigation of Single and Multiple Atomized Water Spray Impingement for Efficient Solar Water Heating
Year: 2025
Type: article
Language: en
Topic: Heat Transfer Mechanisms
Authors and affiliations:
raw_author_name: Vikash Kumar
raw_affiliation_strings: Dr BR Ambedkar National Institute of Technology Department of Mechanical Engineering, ,   , ,
Department of Mechanical Engineering NIT Jalandhar JALANDHAR, PUNJAB 144008 India
raw_author_name: Satyender Singh
raw_affiliation_strings: Dr BR Ambedkar National Institute of Technology Department of Mechanical Engineering, ,   , ,
Department of Mechanical Engineering Dr B R Ambedkar National Institute of Technology Jalandhar, Jalandhar, Punjab 144011 India
raw_author_name: Sanjay Kumar
raw_affiliation_strings: Dr BR Ambedkar National Institute of Technology Department of Mechanical Engineering, ,   , ,
Dr B R Ambedkar National Institute of Technology Jalandhar, Punjab 144011 India
MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY
Year: 2025
Type: article
Language: en
Topic: Neurogenetic and Muscular Disorders Research
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: GAT3: +29%), leading to reduced neuronal GABA and its accumulation in astrocytes. This imbalance leads to cortical GABAergic dysfunction, contributing to SMA pathology and highlighting SMN’s critical role in neurotransmitter regulation. Our data support a mechanistic model in which SMN deficiency impairs cortical GABAergic networks, expanding our understanding of cortical mechanisms in SMA and providing a framework for cortical-targeted therapeutic strategies
S1: -25.7%). Consistently, the density of inhibitory synapses, assessed by gephyrin/GAD puncta, was markedly decreased in the SMA motor CRTX, particularly in layer 5 compared to WT controls (≤50%). Electrophysiological characterizations further confirmed decreased inhibitory neurotransmission onto layer 5 pyramidal neurons. Subsequent analyses showed that SMN loss impairs GABA release and reuptake by altering astrocytic transporter expression (SNAT5: -45%
Spinal Muscular Atrophy (SMA) is a neuromuscular disease due to the lack of Survival Motor Neuron (SMN) protein, characterized by lower motor neuron (MN) degeneration and muscle atrophy. Moreover, evidence shows motor cortex (CRTX) morphofunctional abnormalities in SMA patients, suggesting altered maturation and maladaptive plasticity. Given limited access to patient samples, preclinical models are mandatory to clarify motor cortical involvement and underlying mechanisms in SMA pathogenesis. Building on our previous observation of upper MN vulnerability in SMA mice, we dissected cortical inhibitory GABAergic signalling, metabolism, and interneuron (IN) function in the sensorimotor (SM) CRTX and in primary neuron-astrocyte co-cultures from a severe SMA mouse model, compared to WT controls. Bioinformatic and biochemical analyses revealed stage-specific alterations in GABAergic pathways and metabolite profiles, particularly at late stage (P12), indicating a critical window of cortical network vulnerability. Imaging and molecular studies showed GABA+ neuron loss (-38%) and impaired GABA synthesis (GAD65/67). Moreover, confocal analysis revealed marked morphological alterations of parvalbumin (PV)+ INs in the SM CRTX of SMA mice, characterized by smaller somas and reduced dendritic dendritic complexity compared to controls. To determine whether these changes affected specific cortical layers, we quantified PV+ IN distribution and found a pronounced reduction in layer 5 of the motor CRTX (M1: -33.1%
Prácticas situadas: tres archivos de arquitectura en la ciudad de Buenos Aires
Year: 2025
Type: article
Language: es
Topic: Memory, violence, and history
Authors and affiliations:
raw_author_name: Patricia Méndez
raw_affiliation_strings: Departamento de Artes Integradas, Universidad de Playa Ancha, Chile
CONICET, Argentina. https://ror.org/0171wr661
Blood-based Alzheimer's disease biomarkers and cognitive decline in essential tremor
Year: 2025
Type: article
Language: en
Topic: Neurological disorders and treatments
Authors and affiliations:
raw_author_name: Tomer O Guy
raw_affiliation_strings: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
raw_author_name: Ali Ghanem
raw_affiliation_strings: Department of Neurology, Henry Ford Health System, Detroit, MI, USA
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
raw_author_name: Diane S Berry
raw_affiliation_strings: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
raw_author_name: Nora C Hernandez
raw_affiliation_strings: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
raw_author_name: Vibhash D Sharma
raw_affiliation_strings: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
raw_author_name: Silvia Chapman
raw_affiliation_strings: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA
raw_author_name: Stephanie Cosentino
raw_affiliation_strings: Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA
Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA
raw_author_name: Elan D Louis
raw_affiliation_strings: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
Acerca de acervos de arquitectura mexicana
Year: 2025
Type: article
Language: es
Topic: Architecture, Modernity, and Design
Authors and affiliations:
raw_author_name: Louise Noelle Gras
raw_affiliation_strings: Instituto de Investigaciones Estéticas, Universidad Nacional Autónoma de México, México
raw_author_name: Maria Cristina Nascentes Cabral
raw_affiliation_strings: Programa de Posgrado en Urbanismo
Construir un pozo canadiense en Argentina
Year: 2025
Type: article
Topic: Geothermal Energy Systems and Applications
Authors and affiliations:
raw_author_name: María Belén Birche
raw_affiliation_strings: Universidad Nacional de La Plata, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC), Argentina
raw_author_name: Julián Carelli Cerdá
raw_affiliation_strings: Universidad Nacional de La Plata, Argentina
raw_author_name: Jorge Daniel Czajkowski
raw_affiliation_strings: Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
A NOVEL DRUG TARGETTING THE INFLAMMASOME AMELYORATES AD PATHOLOGY IN THE MURINE MODEL &lt;i&gt;5xFAD&lt;/i&gt;
Year: 2025
Type: article
Language: en
Topic: Inflammasome and immune disorders
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Alzheimer’s disease (AD) is a progressive neurological disorder commonly associated with aging and the main widespread form of dementia. It is known that, concomitant with plaques and tangles accumulation, patients undergo a severe neuroinflammatory and iron accumulation processes that contributes to neuronal loss during AD progression. Currently, available pharmacological treatments are unable to resolve the disease, therefore the development of novel drugs able to prevent neuroinflammation before symptoms are fully present may provide an alternative approach. In this study, 5xFAD mice, a murine model with five familial human AD mutations inducing constitutive amyloid accumulation, have been treated orally from weaning until 5 months of age with INF235. This novel compound is able to inhibit the NLRP3 inflammasome, a multiprotein complex involved in the inflammatory process that plays an active role in the pathogenesis of AD. INF235 treated mice have been compared to non-treated mice and mice treated with MCC950, a well-known NLRP3 inflammasome inhibitor. At the end of the treatment, we conducted a battery of behavioral tests to evaluate the cognitive status of 5xFAD mice and histological analysis of brain tissue. Results showed that, in the asymptomatic phase of AD, mice treated with MCC950 and INF235 have similar behaviour in terms of general cognitive improvement compared to non-treated mice. Moreover, histological staining of the main areas affected by AD (cortex, hippocampus, third ventricle, striatum) revealed a significant reduction in the amount of iron deposits in INF235-treated 5xFAD brains
and inflammatory markers, IBA- 1 and GFAP, showing a significant reduction in the state of activation of glial cells. This preliminary work shows how the novel inflammasome inhibitor, INF235, is able to reduce iron accumulation and the activation state of important players in neurodegeneration offering a novel strategy to deepen into the prevention of not only neuroinflammation but also iron dyshomeostasis during presimptomatic AD. This work is supported by MIUR project ‘Dipartimenti di Eccellenza 2023-2027’ to Department of Neuroscience ‘RitaLevi Montalcini’ to Alessandro Vercelli and Serena Stanga
Displacement in the ICJ's Advisory Opinion on Climate Change
Year: 2025
Type: article
Language: en
Topic: Climate Change, Adaptation, Migration
Authors and affiliations:
raw_author_name: Jane McAdam
raw_affiliation_strings: Kaldor Centre for International Refugee Law
Australian Research Council Laureate Fellow and Director of the Evacuations Research Hub, Kaldor Centre for International Refugee Law, Faculty of Law & Justice, Sydney, Australia
Redefining identity: corporate evolution in the AI era
Year: 2025
Type: article
Language: en
Topic: Corporate Identity and Reputation
Authors and affiliations:
raw_author_name: Giulia Nevi
raw_affiliation_strings: Universitas Mercatorum , ,
Università Politecnica delle Marche , ,
Universitas Mercatorum, Rome, Italy
raw_author_name: Maria Palazzo
raw_affiliation_strings: Universitas Mercatorum , ,
Universitas Mercatorum, Rome, Italy
raw_author_name: Maria Antonella Ferri
raw_affiliation_strings: Universitas Mercatorum , ,
Universitas Mercatorum, Rome, Italy
raw_author_name: Luca Dezi
raw_affiliation_strings: Sapienza University , ,
Sapienza University, Rome, Italy
Narrativas de archivo: un enfoque metodológico puesto a prueba en la enseñanza de un Taller de Investigación
Year: 2025
Type: article
Language: es
Topic: Memory, violence, and history
Authors and affiliations:
raw_author_name: Vhal Alessandro Del Solar
raw_affiliation_strings: Facultad de Arquitectura y Urbanismo, Pontificia Universidad Católica del Perú, Perú
Global burden of disease analysis and projections of ischemic stroke linked to inadequate polyunsaturated fatty acid intake in older women (1990–2021)
Year: 2025
Type: article
Language: en
Topic: Fatty Acid Research and Health
Authors and affiliations:
raw_author_name: Ying Luo
raw_affiliation_strings: Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Laboratory of Neurological Diseases and Brain Function, Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
raw_author_name: Guoliang Zhu
raw_affiliation_strings: Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
raw_author_name: Quandan Tan
raw_affiliation_strings: Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
raw_author_name: Yapeng Lin
raw_affiliation_strings: Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
raw_author_name: Jie Yang
raw_affiliation_strings: Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
STUDY OF THE INITIAL DAMAGE OF A COPPER SLAG ABRASIVE TO INCREASE THE PRODUCTIVITY OF HYDROABRASIVE CUTTING
Year: 2025
Type: article
Language: en
Topic: Mechanical Systems and Engineering
Authors and affiliations:
raw_author_name: Gennady Barsukov
raw_affiliation_strings: Orel State University named after I.S. Turgenev
raw_author_name: Vladimir Shorkin
raw_affiliation_strings: Orel State University named after I.S. Turgenev
raw_author_name: Viktor Vlasov
raw_affiliation_strings: Orel State University named after I.S. Turgenev
raw_author_name: Anton Petrukhin
raw_affiliation_strings: Orel State University named after I.S. Turgenev
raw_author_name: Egor Nozdrin
raw_affiliation_strings: Orel State University named after I.S. Turgenev