LabID-base/OpenAlex-Afillation huggingface dataset:
STANDARDIZING LIGHT SHEET IMAGING AND 3D IMAGE ANALYSIS FOR WHOLE BRAIN VASCULAR NET QUANTIFICATION
Year: 2025
Type: article
Language: en
Topic: Advanced Fluorescence Microscopy Techniques
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Neuronal function relies on a complex network of blood vessels that deliver oxygen and nutrients essential for metabolism. However, our understanding of the intricate capillary network allowing substance and metabolite exchange remains incomplete. While structural cerebral vasculature and molecular analyses hold promise for offering crucial insights into cerebral circulation and cerebrovascular diseases, technical limitations make difficult to obtain detailed 3D structural information on vascular networks, from large vessels to capillaries. Light sheet microscopy (LSM) coupled with tissue clarification, high calculation power and computer vision algorithms, has emerged as a powerful tool in neuroscience research, offering unique advantages for imaging biological large samples at cellular resolution. Despite the vast potential, the pivotal challenge lies in achieving reliable quantitative imaging. To tackle this challenge, we addressed three methodological hurdles: to optimize antibody-stained section imaging employing non-toxic clearing protocols, to set-up quantitative measure using young-C57BL/6 brain tissues, and to test the quantification pipeline on extremely challenging samples, comparing old- C57BL/6 and old-TG2576 mice (a model of Alzheimer’s disease) brain vasculature. To optimize the vessel visualization, we set-up two different stainings in young-C57BL/6 mice: anti-CD31 VioB515 immunostaining and perfusion with dextran-FITC. We used the clearing protocol of Miltenyi MACS® Clearing Kit and Miltenyi UltraMicroscope Blaze™ for imaging, while Miltenyi stitcher software was used for large areas sampling. Three-dimensional, voxel-based images were analyzed using IMARIS software (v. 9.6.2
Oxford Instruments), by the «surface» algorithms to construct the 3D vascular network. We translated the acquisition and 3D reconstruction protocol designed on young-C57BL/6 tissues modifying the algorithm to optimize the analysis on extremely challenging samples: old-derived brains from WT and TG2576 animals. The protocol included a fine study of the fluorescence intensity curve in each sample and experimental group and a mathematic- based approach to correct the inter- and intra-experiment differences. While LSM offers great advantages in imaging large volumes of tissue with high resolution and minimal photobleaching, standardized and optimized protocols for clearing, imaging, and post-processing analysis are a crucial step toward the use LSM for image quantification
Impact of Curcuma longa L. extract supplementation on the gut microbiota of hemodialysis patients
Year: 2025
Type: article
Language: en
Topic: Curcumin's Biomedical Applications
Authors and affiliations:
raw_author_name: Livia Alvarenga
raw_affiliation_strings: Universidade Federal do Rio de Janeiro,  Brazil; Universidade Federal Fluminense,  Brazil
raw_author_name: Ludmila Cardozo
raw_affiliation_strings: Universidade Federal Fluminense,  Brazil; Universidade Federal Fluminense,  Brazil
raw_author_name: Júnia Schultz
raw_affiliation_strings: King Abdullah University of Science and Technology,  Saudi Arabia
raw_author_name: Fluvio Modolon
raw_affiliation_strings: Universidade de São Paulo,  Brazil
raw_author_name: Alexandre Rosado
raw_affiliation_strings: King Abdullah University of Science and Technology,  Saudi Arabia
raw_author_name: Denise Mafra
raw_affiliation_strings: Universidade Federal do Rio de Janeiro,  Brazil; Universidade Federal Fluminense,  Brazil
Equoterapia, Fonoaudiologia e Comunicação: análise de reorganizações linguísticas em crianças com Transtorno do Espectro Autista
Year: 2025
Type: article
Topic: Language Development and Disorders
Authors and affiliations:
raw_author_name: Leticia Correa Celeste
raw_affiliation_strings: Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil
raw_author_name: Amanda de Carvalho Pedra
raw_affiliation_strings: Universidade de Brasília,  Brazil
raw_author_name: Melissa Nara de Carvalho Picinato-Pirola
raw_affiliation_strings: Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil
raw_author_name: Ana Beatriz Morato Ferreira de Sousa
raw_affiliation_strings: Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil
raw_author_name: Daniel Couto Vale
raw_affiliation_strings: Universidade de Brasília,  Brazil
Same disease, different outcomes: a retrospective cohort study of COVID-19–associated AKI across Brazil’s dual-tiered healthcare system
Year: 2025
Type: article
Language: en
Topic: Acute Kidney Injury Research
Authors and affiliations:
raw_author_name: Natália Piazzi de Faria
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil
raw_author_name: José Hermógenes Rocco Suassuna
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil; Kidney Assistance Ltda,  Brazil; Complexo Médico Américas,  Brazil
raw_author_name: Carlos Augusto Moreira de Sousa
raw_affiliation_strings: Fundação Oswaldo Cruz,  Brazil
raw_author_name: Sergio Miranda Freire
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil
raw_author_name: Conrado Lysandro R. Gomes
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil; Kidney Assistance Ltda,  Brazil; Complexo Médico Américas,  Brazil
GLIAL INFLAMMASOME ACTIVATION AND BLOOD-BRAIN BARRIER BREAKDOWN IN AGE-RELATED NEURODEGENERATION
Year: 2025
Type: article
Language: en
Topic: Barrier Structure and Function Studies
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Blood-brain barrier (BBB) breakdown, characterized by the disruption of endothelial tight junctions (TJs), is an early pathogenic event in aging-related neurodegenerative diseases, where neuroinflammation plays a key role. Activation of the NLRP3 inflammasome in glial cells represents a major inflammatory hub contributing to this process. However, its precise role in BBB dysfunction and its potential as a therapeutic target remain to be fully elucidated. In the present study, senescence-accelerated SAMP8 mice and SAMR1 controls were used as models of BBB impairment. Confocal immunofluorescence analysis of brain sections was performed to assess the tight junction proteins occludin and claudin- 5, as well as the inflammasome components NLRP3 and ASC in GFAP+ astrocytes and IBA1+ microglia. The effects of two immunomodulatory treatments–the selective NLRP3 inhibitor MCC950 and interferon-gamma (IFN-γ) – were subsequently evaluated. SAMP8 mice exhibited downregulation and a discontinuous staining pattern of occludin and claudin-5, paralleled by inflammasome activation, including upregulation of NLRP3 and ASC in both reactive astrocytes and microglia. Both MCC950 and IFN-γ treatments partially restored BBB integrity, improving TJ staining pattern and protein expression in both microvessels and larger vessels. Structural recovery of TJs correlated with a significant reduction in NLRP3 expression and ASC speck formation in glial cells. These findings demonstrate that glial inflammasome activation is a key driver of BBB structural failure in this aging model. The partial restoration of TJ architecture following inflammasome inhibition with MCC950 or immunomodulation with IFN-γ confirms the link between neuroinflammation and vascular pathology. Overall, this study identifies the NLRP3 inflammasome pathway as a critical therapeutic target to preserve BBB integrity in age-related neurodegeneration
Pengaruh Motivasi Berinvestasi Syariah, Persepsi Risiko, dan Literasi Keuangan Syariah Terhadap Keputusan Investasi Generasi Z Berbasis Syariah di Era Digital
Year: 2025
Type: article
Topic: Financial Literacy and Behavior
Authors and affiliations:
raw_author_name: Yoga Prasetyo
raw_affiliation_strings: Universitas Paramadina
Eficácia da estimulação transcraniana por corrente contínua no transtorno do processamento auditivo central: revisão sistemática e meta-análise
Year: 2025
Type: article
Topic: Hearing Loss and Rehabilitation
Authors and affiliations:
raw_author_name: Daviany Oliveira Lima
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Sanmara de Andrade
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Davielly Oliveira Lima
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Amanda Camara Miranda
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Mariana Lopes Martins
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Victoria Lais Correia da Cunha
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Marine Raquel Diniz da Rosa
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Eliane Schochat
raw_affiliation_strings: Universidade de São Paulo,  Brazil
Fungal diversity in larval diets of Melipona interrupta: Impacts on queen development and survival
Year: 2025
Type: article
Language: en
Topic: Insect and Arachnid Ecology and Behavior
Authors and affiliations:
raw_author_name: Luana Evillyn Vinente de Queiroz
raw_affiliation_strings: Instituto Nacional de Pesquisas da Amazônia (INPA),  Brasil
raw_author_name: Flavia da Silva Fernandes
raw_affiliation_strings: Instituto Nacional de Pesquisas da Amazônia (INPA),  Brasil
raw_author_name: Gabriel Garcês Santos
raw_affiliation_strings: Instituto Nacional de Pesquisas da Amazônia (INPA),  Brasil; Universidade Estadual do Maranhão (UEMA),  Brasil
raw_author_name: João Vicente Braga de Souza
raw_affiliation_strings: Instituto Nacional de Pesquisas da Amazônia (INPA),  Brasil; Instituto Nacional de Pesquisas da Amazônia (INPA),  Brasil
raw_author_name: Gislene Almeida Carvalho-Zilse
raw_affiliation_strings: Instituto Nacional de Pesquisas da Amazônia (INPA),  Brasil; Instituto Nacional de Pesquisas da Amazônia (INPA),  Brasil
SENSORY NEURON TOXICITY TRIGGERED BY ANTICANCER DRUGS IS COUNTERACTED BY EXTRACELLULAR VESICLES DERIVED FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS
Year: 2025
Type: article
Language: en
Topic: Extracellular vesicles in disease
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and disabling adverse effect of several anticancer drugs, characterized by paraesthesia, numbness, and dysesthesia, often leading to dose reduction or therapy discontinuation. Despite extensive research, no neuroprotective strategy has yet demonstrated definitive clinical efficacy. However, in vitro evidence suggests the therapeutic potential of Adipose-derived mesenchymal Stem Cell Extracellular Vesicles (ASC-EVs). EVs function as key mediators of intercellular communication, transporting proteins, RNAs, and lipids, and ASC-EVs in particular have been implicated in cellular repair mechanisms. In this study, we employed primary cultures of dorsal root ganglion (DRG) neurons isolated from rat embryos, a well-established model for investigating neurotoxicity, neuroprotection, and post-mitotic neuronal development. We specifically investigated the effects of two clinically relevant chemotherapeutic agents – cisplatin (CDDP, 6 μM) and bortezomib (BTZ, 20 nM) – administered either alone or in combination with a single dose of extracellular vesicles (EVs) for 24 and 48 h. Neuronal viability was assessed by a cellular count at bright-field microscopy, quantifying live cells based on the presence of a birefringent outline. Treatment with CDDP resulted in a pronounced and timedependent decline in neuronal viability at both 24 and 48 h. Coadministration with ASC-EVs significantly mitigated this effect, indicating a strong neuroprotective action. In contrast, BTZ induced a distinct neurotoxic profile, characterized by milder alterations at earlier time points – likely reflecting differences in its mechanisms of action compared with CDDP. Despite these differences, ASC-EVs were also able to counteract BTZ-induced toxicity, further reinforcing their neuroprotective potential. Collectively, these results indicate that the neuroprotective efficacy of ASC-EVs is influenced by both the pharmacological properties of the chemotherapeutic agent and the duration of exposure, suggesting a dynamic, time-dependent interplay between EV- mediated mechanisms and drug-induced neuronal stress. The observed protection is plausibly linked to the modulation of oxidative stress and apoptotic pathways, which are currently being explored. Future investigations will aim to identify the specific molecular mechanism within ASC-EVs responsible for mediating these neuroprotective effects
Comment on ar-2025-39
Year: 2025
Type: peer-review
Authors and affiliations:
raw_author_name: Bau, Sébastien
raw_affiliation_strings: INRS, Laboratoire de Métrologie des Aérosols, 54500 Vandoeuvre les Nancy
raw_author_name: Crenn, Vincent
raw_affiliation_strings: ADDAIR, 78530 Buc
raw_author_name: Leglise, Joris
raw_affiliation_strings: ADDAIR, 78530 Buc
raw_author_name: Jacquinot, Sébastien
raw_affiliation_strings: CEA, Laboratoire de Mesures, Sécurisation et Environnement, 38054 Grenoble Cedex 9
raw_author_name: Debert, Christophe
raw_affiliation_strings: Airparif, Laboratoire de métrologie et innovation, 75004 Paris
raw_author_name: Petitprez, Denis
raw_affiliation_strings: Univ. Lille, CNRS, UMR8522 - PC2A – Physico-chimie des Processus de Combustion et de l’Atmosphère, 59000 Lille
raw_author_name: Bizet, Valentine
raw_affiliation_strings: Univ. Lille, CNRS, UMR8522 - PC2A – Physico-chimie des Processus de Combustion et de l’Atmosphère, 59000 Lille
raw_author_name: Leclerc, Lara
raw_affiliation_strings: Mines Saint-Etienne, Univ Jean Monnet, INSERM, U1059 Sainbiose; Centre CIS, 42023 Saint-Etienne
raw_author_name: Miffre, Alain
raw_affiliation_strings: Institut Lumière Matière, UMR 5306 CNRS/U. Lyon, 69622 Villeurbanne cedex
raw_author_name: Cholleton, Danael
raw_affiliation_strings: Institut Lumière Matière, UMR 5306 CNRS/U. Lyon, 69622 Villeurbanne cedex
raw_author_name: Rose, Alec
raw_affiliation_strings: Service des Laboratoires de Santé Environnementale, Laboratoire Polluants Chimiques, 75013 Paris
raw_author_name: Tomas, Alexandre
raw_affiliation_strings: Institut Mines-Télécom, Université de Lille, Center for Energy and Environment, 59000 Lille
raw_author_name: Kort, Amel
raw_affiliation_strings: ASNR, Laboratoire de Physique et de métrologie des aérosols, 91400 Saclay
raw_author_name: Hebert, Didier
raw_affiliation_strings: ASNR, Laboratoire Expérimental de Recherche et d'expertise sur les Transferts des radionucléides dans le milieu  Atmosphérique, 50130 Cherbourg En Cotentin
raw_author_name: Joubert, Aurélie
raw_affiliation_strings: IMT Atlantique, GEPEA, CNRS UMR 6144, BP 20722, 44307 Nantes Cedex 3
raw_author_name: Deschamps, Florence
raw_affiliation_strings: DGA Maîtrise NRBC, 91710 Vert-le-Petit
raw_author_name: Ritoux, Sébastien
raw_affiliation_strings: CSTB, Direction Santé Confort, 77447 Marne-la-Vallée Cedex 2
raw_author_name: Ait Ali Yahia, Lyes
raw_affiliation_strings: CERTES, Université Paris-Est Créteil, 94010 Créteil
raw_author_name: Gaie-Levrel, François
raw_affiliation_strings: LNE, Direction de la Métrologie Scientifique et Industrielle, 75724 Paris Cedex 15
now at: Airparif, The air quality observatory for the Paris region, 7 rue Crillon, 75004 Paris
Efficacy of transcranial direct current stimulation in central auditory processing disorder: A systematic review and meta-analysis
Year: 2025
Type: article
Topic: Transcranial Magnetic Stimulation Studies
Authors and affiliations:
raw_author_name: Daviany Oliveira Lima
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Sanmara de Andrade
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Davielly Oliveira Lima
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Amanda Camara Miranda
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Mariana Lopes Martins
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Victoria Lais Correia da Cunha
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Marine Raquel Diniz da Rosa
raw_affiliation_strings: Universidade Federal da Paraíba,  Brazil
raw_author_name: Eliane Schochat
raw_affiliation_strings: Universidade de São Paulo,  Brazil
Bridging Psychiatry and Neurology: New-Onset Psychogenic Nonepileptic Seizures With Bipolar Disorder
Year: 2025
Type: article
Language: en
Topic: Psychosomatic Disorders and Their Treatments
Authors and affiliations:
raw_author_name: Mridul Sarangal
raw_affiliation_strings: Dr. Sarangal is a third-year psychiatry resident in the Department of Psychiatry and Behavioral Medicine at Carilion Clinic, Virginia Tech Carilion School of Medicine, Roanoke
Mesma doença, desfechos diferentes: um estudo de coorte retrospectivo da IRA associada à COVID-19 no sistema público e privado de saúde do Brasil
Year: 2025
Type: article
Topic: COVID-19 Clinical Research Studies
Authors and affiliations:
raw_author_name: Natália Piazzi de Faria
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil
raw_author_name: José Hermógenes Rocco Suassuna
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil; Kidney Assistance Ltda,  Brazil; Complexo Médico Américas,  Brazil
raw_author_name: Carlos Augusto Moreira de Sousa
raw_affiliation_strings: Fundação Oswaldo Cruz,  Brazil
raw_author_name: Sergio Miranda Freire
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil
raw_author_name: Conrado Lysandro R. Gomes
raw_affiliation_strings: Universidade do Estado do Rio de Janeiro,  Brazil; Kidney Assistance Ltda,  Brazil; Complexo Médico Américas,  Brazil
CONNECTOME-BASED BRAIN FINGERPRINTS PREDICT ART THERAPY RESPONSE IN PARKINSON’S DISEASE
Year: 2025
Type: article
Language: en
Topic: Functional Brain Connectivity Studies
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Art therapy has emerged as a promising non-pharmacological, complementary approach in Parkinson’s Disease (PD), engaging motor, cognitive, and emotional systems and promoting neuroplasticity. However, individual responses to art therapy are highly variable, and predictors of therapeutic efficacy remain largely unknown. Here, we propose a novel framework combining brain fingerprinting and machine learning to predict art therapy outcomes in PD. We mapped functional connectomes from restingstate functional MRI (fMRI) of PD patients before and after art therapy, assessed individual connectome-based fingerprints, and examined their spatial specificity. First, we found that functional connectomes derived from resting-state fMRI retained high levels of identifiability in both healthy controls and patients with PD, indicating that stable and subject-specific brain fingerprints are preserved even in the context of neurodegeneration. Second, we identified associations between fingerprint topography and cognitive domains relevant to PD. Although mean edge-wise reliability was comparable across conditions, the topography of reliability differed by group and session. In PD, reliable edges shifted toward posterior midline and occipital territories, with fewer stable connections in several associative systems. This pattern suggests a shift in reliability toward sensory-perceptual hubs and away from networks that support flexible control. Finally, leveraging network fingerprints, we computed subject-wise topology measures which served as input to a supervised classification framework designed to predict clinical responder versus non-responder status, based on changes in UPDRS-III scores. Among the tested classifiers, treebased methods provided the most robust predictive performance, with random forest achieving the highest performance, with an accuracy of 0.83 and a ROC-AUC of 0.80. Our results demonstrate that brain fingerprint-informed network measures capture interindividual variability in art therapy response, offering a datadriven, personalized approach to rehabilitation. This study provides the first evidence that functional connectome fingerprints can guide art therapy interventions, thus opening a new precision medicine framework in PD
Impacto da suplementação com extrato de Curcuma longa L. na microbiota intestinal de pacientes em hemodiálise
Year: 2025
Type: article
Topic: Curcumin's Biomedical Applications
Authors and affiliations:
raw_author_name: Livia Alvarenga
raw_affiliation_strings: Universidade Federal do Rio de Janeiro,  Brazil; Universidade Federal Fluminense,  Brazil
raw_author_name: Ludmila Cardozo
raw_affiliation_strings: Universidade Federal Fluminense,  Brazil; Universidade Federal Fluminense,  Brazil
raw_author_name: Júnia Schultz
raw_affiliation_strings: King Abdullah University of Science and Technology,  Saudi Arabia
raw_author_name: Fluvio Modolon
raw_affiliation_strings: Universidade de São Paulo,  Brazil
raw_author_name: Alexandre Rosado
raw_affiliation_strings: King Abdullah University of Science and Technology,  Saudi Arabia
raw_author_name: Denise Mafra
raw_affiliation_strings: Universidade Federal do Rio de Janeiro,  Brazil; Universidade Federal Fluminense,  Brazil
Equine-therapy services, speech-language-hearing therapy, and communication: An analysis of linguistic reorganizations in children with autism spectrum disorder
Year: 2025
Type: article
Topic: Human-Animal Interaction Studies
Authors and affiliations:
raw_author_name: Leticia Correa Celeste
raw_affiliation_strings: Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil
raw_author_name: Amanda de Carvalho Pedra
raw_affiliation_strings: Universidade de Brasília,  Brazil
raw_author_name: Melissa Nara de Carvalho Picinato-Pirola
raw_affiliation_strings: Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil
raw_author_name: Ana Beatriz Morato Ferreira de Sousa
raw_affiliation_strings: Universidade de Brasília,  Brazil; Universidade de Brasília,  Brazil
raw_author_name: Daniel Couto Vale
raw_affiliation_strings: Universidade de Brasília,  Brazil
Effectiveness of a Home-Based Telehealth Exercise Program Using the Physitrack® App on Adherence and Vertical Jump Performance in Handball Players: A Randomized, Controlled Pilot Study
Year: 2025
Type: article
Language: en
Topic: Knee injuries and reconstruction techniques
Authors and affiliations:
raw_author_name: Andréa Kwapisz Dos Santos
raw_affiliation_strings: Universidad San Pablo-CEU, CEU Universities, Neuromusculoskeletal and Biomechanics Research Group (NeumBReG), Department of Physiotherapy, School of Medicine, Avda. Montepríncipe, 5, 28925 Alcorcón, Madrid, Spain
raw_author_name: Adrián García Catalán
raw_affiliation_strings: Universidad San Pablo-CEU, CEU Universities, Neuromusculoskeletal and Biomechanics Research Group (NeumBReG), Department of Physiotherapy, School of Medicine, Avda. Montepríncipe, 5, 28925 Alcorcón, Madrid, Spain
raw_author_name: Ángel Luís Rodríguez-Fernández
raw_affiliation_strings: Universidad San Pablo-CEU, CEU Universities, Neuromusculoskeletal and Biomechanics Research Group (NeumBReG), Department of Physiotherapy, School of Medicine, Avda. Montepríncipe, 5, 28925 Alcorcón, Madrid, Spain
raw_author_name: Francisco García-Muro San José
raw_affiliation_strings: Universidad San Pablo-CEU, CEU Universities, Neuromusculoskeletal and Biomechanics Research Group (NeumBReG), Department of Physiotherapy, School of Medicine, Avda. Montepríncipe, 5, 28925 Alcorcón, Madrid, Spain