Engineering vascularized inner ear organoids: Challenges and advances in recapitulating the cochlear microenvironment
Year: 2025
Type: review
Language: en
Topic: Hearing, Cochlea, Tinnitus, Genetics
Authors and affiliations:
raw_author_name: Hao Rong
raw_affiliation_strings: The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315000, China
raw_author_name: Qian Zhu
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China; Department of Rehabilitation Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China
raw_author_name: Zhonghong Zhang
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China; Department of Ophthalmology, Zhongda Hospital Southeast University, 87 Dingjiaqiao, Nanjing, Jiangsu, 210009, China
raw_author_name: Xinyi Pang
raw_affiliation_strings: College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, China
raw_author_name: Jiyang Zuo
raw_affiliation_strings: The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315000, China
raw_author_name: Yusong Wang
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China
raw_author_name: Pan Feng
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China
raw_author_name: Xu Zhang
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China
raw_author_name: Liuying Gao
raw_affiliation_strings: The Affiliated People's Hospital of Ningbo University, Ningbo, 315000, China
raw_author_name: Lei Tian
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. Electronic address: tianlei@seu.edu.cn
raw_author_name: Yangnan Hu
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China; School of Medical Engineering, Affiliated Zhuhai People's Hospital, Beijing Institute of Technology, Zhuhai, 519088, China. Electronic address: yangnanhu@bit.edu.cn
raw_author_name: Zhisen Shen
raw_affiliation_strings: The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315000, China. Electronic address: lhlshenzhisen@nbu.edu.cn
raw_author_name: Renjie Chai
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China; School of Medical Engineering, Affiliated Zhuhai People's Hospital, Beijing Institute of Technology, Zhuhai, 519088, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China; Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China; Southeast University Shenzhen Research Institute, Shenzhen, 518063, China. Electronic address: renjiec@seu.edu.cn