A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F
Year: 2025
Type: article
Language: en
Topic: Axon Guidance and Neuronal Signaling
Authors and affiliations:
raw_author_name: Honglei Tian
raw_affiliation_strings: IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
raw_author_name: Chun Po Fung
raw_affiliation_strings: IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
raw_author_name: Luke Burman
raw_affiliation_strings: aTyr Pharma, San Diego, California, USA
aTyr Pharma, San Diego, CA, 92121, U.S.A
raw_author_name: Yeeting E. Chong
raw_affiliation_strings: aTyr Pharma, San Diego, California, USA
aTyr Pharma, San Diego, CA, 92121, U.S.A
raw_author_name: Changdong Liu
raw_affiliation_strings: Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China
raw_author_name: Yanyan Geng
raw_affiliation_strings: IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
raw_author_name: Lam Yang
raw_affiliation_strings: IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
raw_author_name: Man Wai Chow
raw_affiliation_strings: IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China
raw_author_name: Yingyi Zhang
raw_affiliation_strings: Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China
raw_author_name: Kwok Wa Hugo Ho
raw_affiliation_strings: Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China
raw_author_name: Guang Zhu
raw_affiliation_strings: Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China
raw_author_name: Zhenguo Wu
raw_affiliation_strings: Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China
raw_author_name: Xiang-Lei Yang
raw_affiliation_strings: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, U.S.A
raw_author_name: Zhiwen Xu
raw_affiliation_strings: aTyr Pharma, San Diego, California, USA
aTyr Pharma, San Diego, CA, 92121, U.S.A
raw_author_name: Leslie A. Nangle
raw_affiliation_strings: aTyr Pharma, San Diego, California, USA. Electronic address: lnangle@atyrpharma.com
aTyr Pharma, San Diego, CA, 92121, U.S.A. Electronic address: lnangle@atyrpharma.com