LabID-base/OpenAlex-Afillation huggingface dataset:
NEUROPROTECTIVE POTENTIAL OF ADIPOSE MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES ON DAMAGED MOTONEURONS
Year: 2025
Type: article
Language: en
Topic: Extracellular vesicles in disease
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Intranasal delivery represents a non-invasive and promising route to directly target the central nervous system (CNS), as it enables therapeutic agents to bypass the blood–brain barrier and allows repeated administration with low invasiveness. In this context, extracellular vesicles derived from adipose mesenchymal stem cells (ASC-EVs) are gaining increasing attention for their intrinsic neuroprotective and immunomodulatory properties, making them attractive candidates for the treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). In this study, we established an in vitro epithelial barrier model using RPMI 2650 cells (derived from nasal epithelium carcinoma) cultured on transwell system and coupled with motor neuron-like NSC-34 cells treated with hydrogen peroxide to mimic oxidative stress-induced injury. This setup was designed to investigate the ability of ASC-EVs to cross the epithelial layer, representing the first step of access to the CNS following intranasal administration, and to reach damaged motor neurons. The study also explores the mechanisms underlying epithelial transport by evaluating both transcellular and paracellular routes through the use of selective pathway inhibitors and by monitoring changes in transepithelial electrical resistance (TEER) and junctional integrity. Our findings demonstrate that ASC-EVs are able to traverse the epithelial barrier and reach damaged motor neurons, where they are internalized and exert significant neuroprotective effects. These results provide a mechanistic basis supporting the potential of intranasally delivered ASC-EVs as a non-invasive therapeutic approach for ALS and other neurodegenerative disorders
GENETIC AND MORPHOLOGICAL FACTORS IN CORTICAL FOLDING: STUDIES ON THE ROLANDIC FISSURE
Year: 2025
Type: article
Language: en
Topic: Hemispheric Asymmetry in Neuroscience
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Human cortical folding plays a crucial role in neurodevelopment and cognition. In this study, we analyzed several features of the cerebral sulci that describe their morphology, investigated their genetic correlations, and explored typical patterns of the central sulcus. The genetic and morphological factors underlying variations in sulcal shape remain poorly understood. To address this issue, for simplicity’s sake, we focused on the central fissure of Rolando. This sulcus was chosen because it appears around the 20th week of gestation
Creators of Modern China: 100 Lives from Empire to Republic. Edited by Jessica Harrison-Hall and Julia Lovell. London: Thames and Hudson, 2023. 368 pp. $48 (cloth).
Year: 2025
Type: article
Language: en
Topic: Historical Studies and Socio-cultural Analysis
Authors and affiliations:
raw_author_name: Ines Eben von Racknitz
raw_affiliation_strings: Nanjing University
School of History, Nanjing University, China Email:
Linear Mode Conversion Theory of Radio Emission from Turbulent Solar Wind Plasmas
Year: 2025
Type: article
Language: en
Topic: Solar and Space Plasma Dynamics
Authors and affiliations:
raw_author_name: C. Krafft
raw_affiliation_strings: Laboratoire de Physique des Plasmas (LPP), CNRS, Sorbonne Université, Observatoire de Paris, Université Paris-Saclay, Ecole polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France
Institut Universitaire de France (IUF), Paris, France
raw_author_name: A. S. Volokitin
raw_affiliation_strings: Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation, Troitsk, 142190 Moscow, Russia
Laboratoire de Physique des Plasmas (LPP), CNRS, Sorbonne Université, Observatoire de Paris, Université Paris-Saclay, Ecole polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France
A PILOT STUDY TO INVESTIGATE THE ANTIAGING EFFECTS OF THE OLIVE POMACE BY-PRODUCT ON THE BRAIN OF &lt;i&gt;DROSOPHILA MELANOGASTER&lt;/i&gt;
Year: 2025
Type: article
Language: en
Topic: Edible Oils Quality and Analysis
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Olive pomace (OP), a byproduct of olive oil extraction, retains numerous bioactive compounds (in particular, hydroxytyrosol and tyrosol, but also other beneficial flavonoids, phenols and secoiridoids like luteolin, oleocanthal, and oleuropein) found in extra virgin olive oil, which are recognized for their health-promoting properties, particularly in reducing oxidative stress and inflammation. Recent studies have demonstrated that oleuropein and other polyphenols may exert significant neuroprotective effects contributing to improved cognitive function and reducing neuroinflammation, thereby supporting neuronal health. Furthermore, research suggests that polyphenols can promote neurogenesis and synaptic plasticity, essential processes for maintaining brain function during aging. Dietary supplementation (DS) with OP compounds may positively influence gut microbiota, which interacts with the central nervous system, highlighting the intricate relationship between diet and brain health. Following our observation in a previous study that dietary supplementation with OP significantly increased the half-life in both female and male flies, in the present pilot study, using one of the two OP batches previously employed, we evaluated the effects of dietary supplementation with OP on motor abilities and on the maintenance of brain tissue morphological integrity during aging in female flies. Climbing ability, brain size, and quantitative analyses of vacuole-like degeneration associated with specific brain regions were utilized as indicators of brain functional integrity and neurodegeneration during the aging process. Dietary supplementation commenced at 30 of flies age (w1118 strain), and climbing ability was assessed at the beginning (T0) and after 10 days of OP DS (T1). Brain tissue collections were conducted immediately after the T1 climbing assay. Female flies supplemented with OP exhibited significantly improved climbing activity at T1 (p<0.0188), a trend toward larger brain size (p=0.053) along with a significantly reduced total volume of brain vacuoles compared to flies without DS (p<0.05). The gut microbiota modulation by bioactive compounds has been linked to various health benefits through multiple mechanisms. Understanding how OP-derived polyphenols specifically influence these microbial populations and their functional outputs would provide valuable insights into the neuroprotective and longevity-promoting effects observed in our observations
THE DUAL EFFECT OF CADMIUM IN ASTROCYTE PHYSIOLOGY: FROM ADAPTIVE ACTIVATION TO POTENTIAL NEUROTOXICITY
Year: 2025
Type: article
Language: en
Topic: Heavy Metal Exposure and Toxicity
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: serious risk to human health due to their persistence, bioaccumulation, and toxic effects on various organs and systems. Among them, cadmium (Cd) is of particular concern for its widespread presence in industrial and consumer products, including pesticides, plastics, pigments, and cigarette smoke. However, the early effects of low-dose Cd exposure on human astrocytes remain poorly defined. Astrocytes play a crucial role in maintaining central nervous system (CNS) homeostasis, providing metabolic and structural support to neurons, regulating synaptic activity, and preserving blood–brain barrier (BBB) integrity. In this study, we investigated the impact of Cd acetate (CdAc) on astrocyte viability, migration and activation. The human astrocytic SVGp12 cell line was exposed to increasing concentrations of CdAc (0.1-100 μM) for increasing time 6-48 h. Preliminary results showed that 24 h exposure to 1 μM CdAc induced a significant 10% increase in cell viability compared to untreated astrocytes. In addition, a 30% increase in cell migration was also observed in CdAc-treated cells (1 μM, 24 h) compared to the control, as revealed by wound healing assay. In accordance, CdAc exposure (1 μM, 24 h) induced cytoskeletal rearrangement consistent with a motile phenotype, as demonstrated by F-actin immuno-fluorescence analysis. Moreover, the expression of the astrocyte markers GFAP and S100β was also significantly increased after CdAc exposure (1 μM, 24 h), indicating an early astrocyte activation. In contrast, higher CdAc concentrations (≥5 μM) reduced viability, impaired migration and induced morphological features of cytotoxicity in human astrocytes. In conclusion, our findings indicate that subtoxic Cd exposure may induce an early astrogliosis, affecting migratory ability, viability and activation of human astrocytes. This reactive state may contribute to neuroinflammatory processes and BBB dysfunction, highlighting the potential impact of low environmental Cd levels on CNS homeostasis. This work was supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006) – A Multiscale integrated approach to the study of the nervous system in health and disease (DR. 1553 11.10.2022)
ADAPTIVE TRAFFIC LIGHT CONTROL ALGORITHM BASED ON THE DETECTION OF CARGO TRANSPORT
Year: 2025
Type: article
Language: en
Topic: Transportation Systems and Logistics
Authors and affiliations:
raw_author_name: Aleksey Fadyushin
raw_affiliation_strings: Industrial University of Tyumen
raw_author_name: Anatoly Pistsov
raw_affiliation_strings: Industrial University of Tyumen
Stochastic Frontier Modelling of Technical Efficiency and Input Elasticities in Independent Broiler Production Systems in Sorong Regency, Indonesia
Year: 2025
Type: article
Language: id
Topic: Efficiency Analysis Using DEA
Authors and affiliations:
raw_author_name: Salmon Lokden
raw_affiliation_strings: Dinas Peternakan Kabupaten Sorong, Sorong, Indonesia
raw_author_name: Stepanus Pakage
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
raw_author_name: Fredy Pattiselanno
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
raw_author_name: Mohammad Wajo
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
raw_author_name: Alnita Baaka
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
raw_author_name: Deny Iyai
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
raw_author_name: Hotlan Manik
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
raw_author_name: Elfira K. Suawa
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
raw_author_name: Bernadetta W. I. Rahayu
raw_affiliation_strings: Universitas Papua, Manokwari, Indonesia
BEYOND THE SPINAL CORD: MORPHOLOGICAL ALTERATIONS OF CORTICAL PROJECTION NEURON IN SPINAL MUSCULAR ATROPHY
Year: 2025
Type: article
Language: en
Topic: Neurogenetic and Muscular Disorders Research
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Spinal Muscular Atrophy (SMA) is a life-threatening childhoodonset neurodegenerative disease, caused by loss-of-function mutations in the SMN1 (Survival Motor Neuron 1) gene. While the lack of functional SMN protein is known to cause lower motor neuron (MN) degeneration, growing evidence suggests a broader pathological impact involving also other organs, including the brain. Nonetheless, the involvement of the sensorimotor cortex in SMA pathology, remains unclear. To determine the effect of SMN reduction on the survival and morphology of cortical projection neurons, we examined the somatosensory cortex of SMAΔ7 mice, a severe SMA model, at early (P5) and late (P11) symptomatic stages. Our findings indicate a selective vulnerability in cortical projection neurons: indeed at P11, we observed a 50% reduction in corticospinal neurons and a 36% reduction in callosal neurons. Interestingly, corticothalamic neurons show no sign of degeneration. Moreover, in SMA condition, corticospinal and callosal neurons exhibit alterations in morphological traits: this includes a significant decrease in soma size (by -32%% and -17.8%, respectively), alongside a reduction in basal dendrite length (-41% and - 40%) and complexity (-64% and -46%). Furthermore, these neuron populations display a less mature dendritic spine phenotype, characterized by an increase in filopodia and a decrease in mushroom spines compared to wild-type controls. In marked contrast, corticothalamic neurons appeared resistant, showing no signs of degeneration or evident morphological changes. These data suggest that specific populations of cortical projection neurons are uniquely sensitive to SMN absence. Interestingly, while the most severe cell death was observed at P11, the morphological changes detailed above in cortical projection neurons were already evident at the early stage of P5, coinciding with the onset of spinal MN degeneration. The identification of these early morphological markers of either vulnerability or resistance across distinct cortical cell types is essential to advancing our understanding of SMA progression and may reveal novel, selective therapeutic targets to preserve upper motor circuit function
Application of Lean tools for the improvement of management processes in an agri-food services company
Year: 2025
Type: article
Topic: Quality and Supply Management
Authors and affiliations:
raw_author_name: Mauricio Romero-Montoya
raw_affiliation_strings: Tecnológico Nacional de México, Instituto Tecnológico de Orizaba
raw_author_name: Miguel J. Heredia-Roldán
raw_affiliation_strings: Tecnológico Nacional de México, Instituto Tecnológico de Orizaba
raw_author_name: María E. Gurruchaga-Rodríguez
raw_affiliation_strings: Tecnológico Nacional de México, Instituto Tecnológico de Orizaba
raw_author_name: Hugo Romero-Montoya
raw_affiliation_strings: Tecnológico Nacional de México, Instituto Tecnológico de Toluca
raw_author_name: Víctor R. Castillo-Intriago
raw_affiliation_strings: Tecnológico Nacional de México, Instituto Tecnológico de Orizaba
20 lat rocznika „Zagłada Żydów. Studia i Materiały” 2005–2025
Year: 2025
Type: article
Language: pl
Topic: Polish-Jewish Holocaust Memory Studies
Authors and affiliations:
raw_author_name: Dariusz Libionka
raw_affiliation_strings: Centrum Badań nad Zagładą Żydów, Instytutu Filozofii i Socjologii PAN
raw_author_name: Barbara Engelking
raw_affiliation_strings: Centrum Badań nad Zagładą Żydów, Instytutu Filozofii i Socjologii PAN
&lt;i&gt;EX VIVO&lt;/i&gt; MAPPING OF NIGRO-THALAMIC DOPAMINERGIC TERMINALS REVEALS REGIONAL SPECIALIZATION AND SYNAPTIC MARKERS IN THE HUMAN THALAMUS
Year: 2025
Type: article
Language: en
Topic: Neurological disorders and treatments
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: The thalamus plays a crucial role in integrating subcortical inputs and relaying them to cortical circuits, yet the extent and specificity of dopaminergic innervation to human thalamic nuclei remain incompletely understood. Recent tractographybased studies suggest the existence of direct nigro-thalamic pathways, but direct histological evidence is still limited. In this study, we provide an ex vivo mapping of dopaminergic projections to the human thalamus using high-resolution immunohistochemistry and confocal microscopy. Human brain specimens were processed to detect multiple dopaminergic markers, including tyrosine hydroxylase (TH), vesicular monoamine transporter 2 (VMAT2), and aromatic L-amino acid decarboxylase (AADC), across anatomically defined thalamic nuclei. Multilabel immunofluorescence and 3D reconstruction allowed precise identification of axonal arborization and synaptic varicosities within the mediodorsal (MD), and ventral anterior (VA)/ventral lateral (VL) nuclei. Quantitative analysis revealed a significant expression of TH+/VMAT2+ fibers and D2R staining in the MD/VA/VL nuclei, supporting the notion of region-specific dopaminergic input. These results provide the first immunohistological confirmation of selective dopaminergic innervation of the human thalamus. This structural evidence complements prior neuroimaging findings and suggests a potential role for the nigro- thalamic pathway in modulating thalamo-cortical circuits involved in executive and cognitive functions
<i>Helicobacter pylori</i> infection aggravates hepatic steatosis by lactylation-driven WTAP-mediated m <sup>6</sup> A modification
Year: 2025
Type: article
Language: en
Topic: RNA modifications and cancer
Authors and affiliations:
raw_author_name: Han Chen
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
raw_author_name: Zi Wang
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
raw_author_name: Yan Wang
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
raw_author_name: Shuo Li
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
raw_author_name: Wei Su
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
raw_author_name: Yuting Shao
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
raw_author_name: Guoxin Zhang
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
raw_author_name: Yun Liu
raw_affiliation_strings: Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University
Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University
raw_author_name: Qiang Ye
raw_affiliation_strings: Department of Gastroenterology, Zhenjiang First People's Hospital
raw_author_name: Xiaoying Zhou
raw_affiliation_strings: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University
The First Clinical Medical College, Nanjing Medical University
NEUROACTIVE STEROIDS PROTECT FROM BORTEZOMIB-INDUCED TOXICITY: EVIDENCE FROM &lt;i&gt;IN VITRO&lt;/i&gt; MODELS
Year: 2025
Type: article
Language: en
Topic: Cancer Treatment and Pharmacology
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Chemotherapy has significantly improved patient survival but has also increased the incidence of chemotherapy-induced peripheral neuropathy (CIPN), a common side effect that affects the patients’ quality of life and limits treatment efficacy. Among the agents associated with CIPN development, bortezomib (BTZ) - a proteasome inhibitor used in the treatment of multiple myeloma - is known to induce painful peripheral neuropathy (BIPN), for which analgesic options remain limited. Recent evidence suggests that neuroactive steroids (NAS), cholesterol derivatives with already proven beneficial effects towards both the central and the peripheral nervous system, may promote neuroprotection in CIPN models. For our study, we selected a palette of different NAS for screening and dose-finding purposes. First, we tested them (alone and in combination with BTZ) in two different cell lines: F11, a somatic cell hybrid of a rat embryonic dorsal root ganglion (DRG) and mouse neuroblastoma cell line N18TG2, and MSC80, a mouse Schwann cell line. To assess the effects of these treatments, cell viability in F11 and MSC80 cell lines was evaluated via crystal violet assay after 24 h of treatment with BTZ (10 nM) alone or in combination with the respective NAS (100 nM). Based on the results, we selected three NAS for further experiments: pregnenolone (PREG) and dihydroprogesterone (DHP), that partially but significantly prevented BTZ-induced cytotoxicity in F11 and MSC80, respectively, as well as allopregnanolone (ALLO), that was mildly protective in both cellular models. Subsequently, we decided to test the abovementioned combinations (BTZ + PREG/DHP/ALLO) in a more complex in vitro model, using organotypic cultures from embryonic rat DRGs. DRGs from E15 rat embryos were treated with a toxic dose of BTZ (5 nM) for 24 or 48 h. The neurotoxic effect was assessed by measuring neurite length of DRG explants. ALLO and PREG were able to protect from the toxicity induced by BTZ exposure at different degrees in both time points, demonstrating their neuroprotective action, whereas DHP was ineffective at any time point. Taken together, our results highlight PREG and ALLO as promising neuroprotective agents in BIPN in vitro models, paving the way for future experiments aimed at testing their efficacy in BIPN in vivo models as well as addressing their specific mechanism of action in counteracting BTZ-induced toxicity. This research has received funding from EU in NextGenerationEU plan through the Italian “Bando Prin 2022D.D. 1409 del 14-09- 2022”
Low-Cost Process Interventions for Quality and Efficiency Improvement in Traditional Pita Bread Manufacturing
Year: 2025
Type: article
Topic: Food composition and properties
Authors and affiliations:
raw_author_name: María L. Abdala-Castillo
raw_affiliation_strings: Tecnológico Nacional de México – Instituto Tecnológico de Orizaba
raw_author_name: Angelica M. Bello
raw_affiliation_strings: Tecnológico Nacional de México – Instituto Tecnológico de Orizaba
raw_author_name: Miguel A. Abdala-Castillo
raw_affiliation_strings: Tecnológico Nacional de México – Instituto Tecnológico de Orizaba
raw_author_name: Marco A. Alamillo-Nieto
raw_affiliation_strings: Tecnológico Nacional de México – Instituto Tecnológico de Orizaba
Well-functioning depression care collaboration: general practitioners’ experiences with specialized mental health services
Year: 2025
Type: article
Language: en
Topic: Mental Health Treatment and Access
Authors and affiliations:
raw_author_name: Ina Grung
raw_affiliation_strings: Department of Global Public Health and Primary Care, University of Bergen
Research Unit for General Practice, NORCE Norwegian Research Centre
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway
raw_author_name: Stefan Hjørleifsson
raw_affiliation_strings: Department of Global Public Health and Primary Care, University of Bergen
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
raw_author_name: Norman Anderssen
raw_affiliation_strings: Department of Psychosocial Science, University of Bergen
Department of Psychosocial Science, University of Bergen, Bergen, Norway
raw_author_name: Berit Bringedal
raw_affiliation_strings: Institute for Studies of the Medical Profession
Institute for Studies of the Medical Profession, Oslo, Norway
raw_author_name: Øystein Hetlevik
raw_affiliation_strings: Department of Global Public Health and Primary Care, University of Bergen
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway