Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy
Year: 2025
Type: article
Language: en
Topic: Immunodeficiency and Autoimmune Disorders
Authors and affiliations:
raw_author_name: Xiaolu Ge
raw_affiliation_strings: Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine; Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine
Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
raw_author_name: Liang Yu
raw_affiliation_strings: Department of Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
raw_author_name: Lei Zhang
raw_affiliation_strings: Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine; Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine
raw_author_name: Liqing Jia
raw_affiliation_strings: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China
raw_author_name: Mingjing Meng
raw_affiliation_strings: Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine; Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine
raw_author_name: Jingquan He
raw_affiliation_strings: Department of Radiotherapy, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China
raw_author_name: Fan Bu
raw_affiliation_strings: Department of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China
raw_author_name: Yue Song
raw_affiliation_strings: Department of Medical Laboratory Science, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
raw_author_name: Gaorui Sun
raw_affiliation_strings: Suzhou Guokuang Pharm Tech. Co., Ltd, Suzhou, Jiangsu, 215000, China
raw_author_name: Shiming Lv
raw_affiliation_strings: Suzhou Guokuang Pharm Tech. Co., Ltd, Suzhou, Jiangsu, 215000, China
raw_author_name: Desheng Mei
raw_affiliation_strings: Suzhou Guokuang Pharm Tech. Co., Ltd, Suzhou, Jiangsu, 215000, China
raw_author_name: Yutao Yang
raw_affiliation_strings: School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China
raw_author_name: Dakang Xu
raw_affiliation_strings: Department of Medical Laboratory Science, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
raw_author_name: Jingfa Zhang
raw_affiliation_strings: The International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen); C-MER Dennis Lam & Partners Eye Center, C-MER International Eye Care Group, Hong Kong, 999077, China
The International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen)
C-MER Dennis Lam & Partners Eye Center, C-MER International Eye Care Group, Hong Kong, 999077, China
raw_author_name: Shengping Zhang
raw_affiliation_strings: Biomedical Translational Research Institute, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong, 255049, China
raw_author_name: Chuangui Wang
raw_affiliation_strings: Biomedical Translational Research Institute, School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong, 255049, China
raw_author_name: Deshui Jia
raw_affiliation_strings: Laboratory of Cancer Genomics and Biology, Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
raw_author_name: Yongping Chen
raw_affiliation_strings: Noble Life Sciences Inc, Sykesville, Maryland, 21784, USA
raw_author_name: Yue Gao
raw_affiliation_strings: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, China. gaoyue@bmi.ac.cn
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, China
raw_author_name: Baokun He
raw_affiliation_strings: Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine; Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. hbk3397@gzucm.edu.cn
Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China
Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine