LabID-base/OpenAlex-Afillation huggingface dataset:
&lt;i&gt;5XFAD&lt;/i&gt; MOUSE MODEL: INVESTIGATING BRAIN IRON IMBALANCE AND MITOCHONDRIAL FEATURES’ ALTERATION
Year: 2025
Type: article
Language: en
Topic: Neurological diseases and metabolism
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: In the brain iron supports neuronal activity and neurotransmitter synthesis. The primary site of iron utilization is mitochondria where it is required for the formation of cofactors essential to redox reactions and energy metabolism, such as ATP production via the electron transport chain (OXPHOS). We previously showed that iron dyshomeostasis occurs with aging, and evidence links disrupted iron balance to mitochondrial dysfunction, energy loss and neuronal death in neurodegenerative diseases like Alzheimer’s disease (AD). The role of brain iron-driven mitochondrial impairment in AD remains unclear. Here, we examined iron homeostasis during the pre-symptomatic phase in 5xFAD mice, carrying five familial human AD mutations. At 2 months, 5xFAD mice showed marked brain iron accumulation in subcortical and striatal areas as revealed by Prussian blue Perl’s staining along with early intracellular amyloid-beta deposition. Due to mitochondria’s key role in iron trafficking and utilization, enriched mitochondrial fractions isolated from 5xFAD brains showed increased expression of mitochondrial number verified by TOM20, mitochondrial aconitase and OXPHOS complexes. Interestingly, we found a significant increase of mitochondrial ferritin, the iron stock within mitochondria, indicating altered iron handling. Moreover, the increased mitochondrial number is not due to de novo biogenesis, as shown by unchanged expression of Cytochrome b, NADH dehydrogenase 1, and PGC-1α
instead, it results from mitochondrial accumulation. Indeed, we found a marked reduction in markers of autophagy and of mitophagy, indicating compromised autophagy in 5xFAD mice and sustaining the previous results of mitochondria accumulation. Furthermore, accumulated mitochondria showed reduced ATP production and respiration while oxidative stress markers were increased. These findings reveal early disruptions in brain iron metabolism and mitochondrial turnover, highlighting mitochondrial iron as a potential target for Alzheimer’s disease. This work is supported by MIUR project “Dipartimenti di Eccellenza 2023-2027” to Department of Neuroscience “RitaLevi Montalcini”, Fondazione CRT “Richieste Ordinarie 2021”, UNITO and UNITA grants for Internationalization 2022 to Serena Stanga
A PRECLINICAL STUDY ON THE MODULATION OF THE MICROBIOTA–GUT–BRAIN AXIS BY A FUNCTIONAL SNACK PROMOTING HEALTHY AGING
Year: 2025
Type: article
Language: en
Topic: Gut microbiota and health
Authors and affiliations:
raw_author_name: Share
raw_affiliation_strings: Clinical and preclinical studies increasingly report alterations in gut microbial composition and reduced microbial diversity in patients with Alzheimer’s disease (AD), suggesting the gut ecosystem may influence disease onset and progression. Preclinical studies in transgenic AD mouse models indicate that gut dysbiosis could be correlated with impaired intestinal barrier function, local deposition of amyloid-β (Aβ) in the gastrointestinal tract, and regional and systemic inflammatory changes. These alterations have been proposed to accelerate central Aβ accumulation and neuroinflammation through immune and metabolic pathways. Together, these findings support a model in which gut microbiota and mucosal barrier modulation contribute to reinforce the cascade that may promote neuropathology in AD. However, although causal links in humans remain to be fully established. A novel engineered health-promoting cookie formulated with red lentil prebiotics and coated in multi-strain probiotic (SLAB51®)-fortified chocolate was tested in 3xTg-AD mice. At eight weeks of age, mice were divided into experimental groups and subjected to a four-month supplementation protocol. The groups received a functional cookie containing the prebiotic and probiotic formulation, a prebiotic cookie without SLAB51®, a standard recipe cookie, or SLAB51® administered in drinking water. The possible effects on intestinal mucosa morphology, secretion and integrity, neuroplasticity in the enteric and central nervous system, and neuroinflammation were evaluated with biochemical and immunohistochemical approaches. Experimental groups receiving the functional snack exhibited well-preserved intestinal wall architecture and a restoration of epithelial homeostasis. These effects were associated with enhanced mucus layer stability and improved barrier integrity, linked by attenuated pro-inflammatory microenvironment consequent to the decrease in enteric glial cells activation. Furthermore, the intake of this symbiotic formulation preserved cognitive function and was associated with decreased amyloid load, oxidative stress, gliosis, and neuroinflammation in brain areas including the hippocampal region. This symbiotic formulation represents a novel dietary vehicle that may provide a nutritional approach to mitigate AD–related microbiota–gut–brain axis disturbances and promote healthy aging. Funded by Next Generation EU - program “MUR-Fondo Promozione e Sviluppo - D.M. 737/2021, PROTECTIVE, Design and development of probiotic and prebiotic functional cookies to counteract cognitive decline”
Arthroscopic Bankart Repair Provides Satisfactory Outcomes for Both Central-Track and Peripheral-Track Lesions in Noncontact Athletes With a Minimum 8-Year Follow-up
Year: 2025
Type: article
Language: en
Topic: Shoulder Injury and Treatment
Authors and affiliations:
raw_author_name: Muhammed Furkan Tosun
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Yenimahalle Training and Research Hospital, Ankara, Turkey
raw_author_name: Ethem Burak Oklaz
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
Department of Radiology, Bilkent City Hospital, Ankara, Turkey
raw_author_name: Ethem Burak Oklaz
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
Department of Radiology, Bilkent City Hospital, Ankara, Turkey
Department of Orthopaedics and Traumatology, Samsun University Faculty of Medicine, Samsun, Turkey
raw_author_name: Ahmet Emin Okutan
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Samsun University Faculty of Medicine, Samsun, Turkey
Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
raw_author_name: Furkan Aral
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
Department of Orthopaedics and Traumatology, Samsun University Faculty of Medicine, Samsun, Turkey
raw_author_name: Toygun Kagan Eren
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey
raw_author_name: Seda Nur Tosun
raw_affiliation_strings: Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey
Department of Radiology, Bilkent City Hospital, Ankara, Turkey
raw_author_name: Elif Banu Guler Oklaz
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
Department of Radiology, Bilkent City Hospital, Ankara, Turkey
raw_author_name: Elif Banu Guler Oklaz
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
Department of Radiology, Bilkent City Hospital, Ankara, Turkey
raw_author_name: Ulunay Kanatli
raw_affiliation_strings: Department of Orthopaedics and Traumatology, Gazi University Faculty of Medicine, Ankara, Turkey
Promoting an energy-based pedestrian planning method: Explanation of desire paths in urban green areas
Year: 2025
Type: article
Language: en
Topic: Urban Transport and Accessibility
Authors and affiliations:
raw_author_name: Ádám Ungvárai
raw_affiliation_strings: Department of Civil Engineering, Faculty of Engineering, University of Debrecen, Debrecen, Hungary
raw_author_name: Brigitta K. Tóth
raw_affiliation_strings: Department of Structural Mechanics, Faculty of Civil Engineering, Budapest University of Technology and Economics, Budapest, Hungary
raw_author_name: András Lengyel
raw_affiliation_strings: Department of Structural Mechanics, Faculty of Civil Engineering, Budapest University of Technology and Economics, Budapest, Hungary
Can machine learning help to unify river selection for small-scale map design?
Year: 2025
Type: article
Language: en
Topic: Flood Risk Assessment and Management
Authors and affiliations:
raw_author_name: Iga Ajdacka
raw_affiliation_strings: Department of Geoinformatics, Cartography and Remote Sensing, Faculty of Geography and Regional Studies, University of Warsaw, Warsaw, Poland
raw_author_name: Izabela Karsznia
raw_affiliation_strings: Department of Geoinformatics, Cartography and Remote Sensing, Faculty of Geography and Regional Studies, University of Warsaw, Warsaw, Poland
archivo en evidencia
Year: 2025
Type: article
Language: es
Topic: Digital and Traditional Archives Management
Authors and affiliations:
raw_author_name: Andrés Martín Passaro
raw_affiliation_strings: Programa de Posgrado en Urbanismo, Facultad de Arquitectura y Urbanismo, Universidad Federal de Río de Janeiro
raw_author_name: Adriana María Collado
raw_affiliation_strings: Facultad de Arquitectura, Diseño y Urbanismo, Universidad Nacional del Litoral
raw_author_name: Maria Cristina Nascentes Cabral
raw_affiliation_strings: Programa de Posgrado en Urbanismo, Facultad de Arquitectura y Urbanismo, Universidad Federal de Río de Janeiro
Deep unsupervised learning-based supplier selection and ranking for assembly manufacturing
Year: 2025
Type: article
Language: en
Topic: Advanced Graph Neural Networks
Authors and affiliations:
raw_author_name: Suyoung Park
raw_affiliation_strings: George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
raw_author_name: Shreyes N. Melkote
raw_affiliation_strings: George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Improvement in quality of life of bitches with malignant mammary neoplasms after unilateral mastectomy and regional lymphadenectomy
Year: 2025
Type: article
Language: en
Topic: Veterinary Oncology Research
Authors and affiliations:
raw_author_name: Mara Tatiani da Silva Bossi
raw_affiliation_strings: Programa de Pós-Graduação em Saúde, Bem-estar e Produção Animal Sustentável na Fronteira Sul (PPG-SBPAS), Universidade Federal da Fronteira Sul (UFFS), Realeza, SC, Brazil
raw_author_name: Maria Helena Moreno
raw_affiliation_strings: Universidade Federal da Fronteira Sul (UFFS), Realeza, SC, Brazil
raw_author_name: Najla Ibrahim Isa Abdel Hadi
raw_affiliation_strings: Programa de Pós-Graduação em Saúde, Bem-estar e Produção Animal Sustentável na Fronteira Sul (PPG-SBPAS), Universidade Federal da Fronteira Sul (UFFS), Realeza, SC, Brazil
raw_author_name: Alice Vicenzi
raw_affiliation_strings: Veterinarian autonomous, Arapoti, SC, Brazil
raw_author_name: Camila Regina Teixeira de Oliveira
raw_affiliation_strings: Univel Centro Universitário, Cascavel, SC, Brazil
raw_author_name: Evandro de Oliveira Rodrigues
raw_affiliation_strings: Programa de Pós-Graduação em Saúde, Bem-estar e Produção Animal Sustentável na Fronteira Sul (PPG-SBPAS), Universidade Federal da Fronteira Sul (UFFS), Realeza, SC, Brazil
raw_author_name: Letícia Maria Silva dos Santos
raw_affiliation_strings: Programa de Pós-Graduação em Saúde, Bem-estar e Produção Animal Sustentável na Fronteira Sul (PPG-SBPAS), Universidade Federal da Fronteira Sul (UFFS), Realeza, SC, Brazil
raw_author_name: Leonardo Gruchowski
raw_affiliation_strings: Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
raw_author_name: Camila Dalmolin
raw_affiliation_strings: Faculdade Mater Dei (UNIMATER), Pato Branco, PR, Brazil
raw_author_name: Fabiana Elias
raw_affiliation_strings: Universidade Federal da Fronteira Sul (UFFS), Realeza, SC, Brazil
raw_author_name: Fabíola Dalmolin
raw_affiliation_strings: Programa de Pós-Graduação em Saúde, Bem-estar e Produção Animal Sustentável na Fronteira Sul (PPG-SBPAS), Universidade Federal da Fronteira Sul (UFFS), Realeza, SC, Brazil
Generalized dual-phase-lag thermoelastic diffusion with Soret and Dufour effects in an infinite hollow cylinder
Year: 2025
Type: article
Language: en
Topic: Thermoelastic and Magnetoelastic Phenomena
Authors and affiliations:
raw_author_name: Mohamed G. Salem
raw_affiliation_strings: Department of Mathematics, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
raw_author_name: Ahmed E. Abouelregal
raw_affiliation_strings: Department of Mathematics, College of Science, Jouf University, Sakaka 2014, Saudi Arabia
Department of Mathematics, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
raw_author_name: Hamid M. Sedighi
raw_affiliation_strings: Mechanical Engineering Department, Faculty of Engineering, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Integrating village health teams into the prevention and management of hypertension and diabetes among people living with HIV in rural Uganda
Year: 2025
Type: article
Topic: HIV-related health complications and treatments
Authors and affiliations:
raw_author_name: Peninah Singura
raw_affiliation_strings: Royal Society of Tropical Medicine and Hygiene, London, England, 2RinceCynth Advisory Limited, Kampala, Uganda
Dairy farming and climate parameters: an analysis of high productivity milk-producing cities in Minas Gerais, the leading dairy state in Brazil
Year: 2025
Type: article
Language: en
Topic: Effects of Environmental Stressors on Livestock
Authors and affiliations:
raw_author_name: Marcus Vinícius Dias-Souza
raw_affiliation_strings: Escola de Educação e Saúde, Centro Universitário Católica do Leste de Minas Gerais, Coronel Fabriciano, MG, Brazil
raw_author_name: Gustavo Augusto Bitancourt Oliveira
raw_affiliation_strings: Escola de Educação e Saúde, Centro Universitário Católica do Leste de Minas Gerais, Coronel Fabriciano, MG, Brazil
raw_author_name: Amanda de Barros Martins
raw_affiliation_strings: Escola de Educação e Saúde, Centro Universitário Católica do Leste de Minas Gerais, Coronel Fabriciano, MG, Brazil
Development and evaluation of a multi-model stacking approach for caries risk assessment in adults using supervised machine learning
Year: 2025
Type: article
Language: en
Topic: Dental Health and Care Utilization
Authors and affiliations:
raw_author_name: Mohd Hidir Mohd Atni
raw_affiliation_strings: Centre of Population Oral Health and Clinical Prevention Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia; Oral Health Programme, Ministry of Health Malaysia, Putrajaya, Malaysia
Centre of Population Oral Health and Clinical Prevention Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia
Oral Health Programme, Ministry of Health Malaysia, Putrajaya, Malaysia
raw_author_name: Nik Mohd Mazuan Nik Mohd Rosdy
raw_affiliation_strings: Centre of Oral & Maxillofacial Diagnostics and Medicine Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia
raw_author_name: Mohd Azrul Amir Muhamad Tajudin
raw_affiliation_strings: Jabatan Digital, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia
raw_author_name: Ahmad Adam Rusly
raw_affiliation_strings: Jabatan Digital, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia
raw_author_name: Noor Asilati Abdul Raob
raw_affiliation_strings: Centre of Population Oral Health and Clinical Prevention Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia; Oral Health Programme, Ministry of Health Malaysia, Putrajaya, Malaysia
Centre of Population Oral Health and Clinical Prevention Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia
Oral Health Programme, Ministry of Health Malaysia, Putrajaya, Malaysia
raw_author_name: Budi Aslinie Md Sabri
raw_affiliation_strings: Centre of Population Oral Health and Clinical Prevention Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia. budiaslinie@uitm.edu.my
Centre of Population Oral Health and Clinical Prevention Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh, Malaysia
Reference Ranges for Corpus Callosum and Cerebellar Vermis Measurements in Fetuses Between 18-36 Weeks of Gestation
Year: 2025
Type: article
Language: en
Topic: Fetal and Pediatric Neurological Disorders
Authors and affiliations:
raw_author_name: Gorkem Arica
raw_affiliation_strings: Istanbul University-Cerrahpasa Cerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Istanbul, Turkey
raw_author_name: Verda Alpay
raw_affiliation_strings: Basaksehir Cam and Sakura State Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey
raw_author_name: Didem Kaymak
raw_affiliation_strings: Istanbul Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey
raw_author_name: Ebru Alici Davutoglu
raw_affiliation_strings: Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Obstetrics and Gynecology, Istanbul, Turkey
raw_author_name: Riza Madazli
raw_affiliation_strings: Istanbul University-Cerrahpasa Cerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Istanbul, Turkey
Cognitive training shapes brain plasticity and schematic representations
Year: 2025
Type: review
Language: en
Topic: Cognitive Abilities and Testing
Authors and affiliations:
raw_author_name: Wenqi Chen
raw_affiliation_strings: Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
raw_author_name: Yan Hao
raw_affiliation_strings: Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. haoyaner@163.com
Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, China. haoyaner@163.com
Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
ON THE PROBLEM OF ASSESSING THE STABILITY OF FREIGHT TRAIN CARS IN CROSSWIND
Year: 2025
Type: article
Language: en
Topic: Aerodynamics and Fluid Dynamics Research
Authors and affiliations:
raw_author_name: Oleg Pudovikov
raw_affiliation_strings: Russia University of Transport
raw_author_name: Shohruh Kahramonov
raw_affiliation_strings: Russian University of Transport
Reply on RC2
Year: 2025
Type: peer-review
Authors and affiliations:
raw_author_name: Alexandre Roy
raw_affiliation_strings: Centre d’Études Nordiques, Université Laval, Québec, QC, G1V 0A6, Canada
Département des Sciences de l’Environnement, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada, G9A  5H7
Centre d'Études Nordiques, Université Laval, Québec, QC, G1V 0A6, Canada
Département des Sciences de l'Environnement, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada, G9A  5H7
The impact mechanism of artificial intelligence dependence on college students’ innovation capability: an empirical study from China
Year: 2025
Type: article
Language: en
Topic: AI in Service Interactions
Authors and affiliations:
raw_author_name: Zhixin Yang
raw_affiliation_strings: School of Management, Guangxi Minzu University, Nanning, China
raw_author_name: Hao Deng
raw_affiliation_strings: School of Management, Guangxi Minzu University, Nanning, China
raw_author_name: Nan Jiang
raw_affiliation_strings: School of Management, Guangxi Minzu University, Nanning, China
INFLUENCE OF LOW-ENERGY ION FLOW ON THE PHYSICAL PROPERTIES OF CARBON FIBERS AND FABRICS USED AS REINFIRCING ELEMENTS FOR PRODUCING COMPOSITE MATERIALS
Year: 2025
Type: article
Language: en
Topic: Material Properties and Applications
Authors and affiliations:
raw_author_name: Farida Sagitova
raw_affiliation_strings: Kazan National Research Technological University
raw_author_name: Farid Sharifullin
raw_affiliation_strings: Kazan National Research Technological University
raw_author_name: Ildar Abdullin
raw_affiliation_strings: Plasma-VST
Reply on RC3
Year: 2025
Type: peer-review
Authors and affiliations:
raw_author_name: Alexandre Roy
raw_affiliation_strings: Centre d’Études Nordiques, Université Laval, Québec, QC, G1V 0A6, Canada
Département des Sciences de l’Environnement, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada, G9A  5H7
Centre d'Études Nordiques, Université Laval, Québec, QC, G1V 0A6, Canada
Département des Sciences de l'Environnement, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada, G9A  5H7
Répétition vs Reformulation : pour une dichotomie stricte
Year: 2025
Type: book-chapter
Language: fr
Topic: Political Systems and Governance
Authors and affiliations:
raw_author_name: Vassiliadou, Hélène
raw_affiliation_strings: LILPA - Linguistique, Langues et Parole (LiLPa Université de Strasbourg - Faculté des Lettres 14 rue Descartes - F-67084 Strasbourg Cedex - France)
Chapitre IV : Thierry CLAEYS et Aurelia GHETIVU, « Armand Moisant et la société Moisant-Laurent-Savey. La naissance et le développement d’une entreprise de serrurerie et de construction métallique prestigieuse »
Year: 2025
Type: book-chapter
Language: fr
Topic: Social Sciences and Governance
Authors and affiliations:
raw_author_name: Ghetivu, Aurelia
raw_affiliation_strings: IHD - Institut d'histoire du droit Jean Gaudemet (12 place du Panthéon 75006 Paris - France)
Front Cover: Dearomative Higher‐Order Cycloaddition for the Construction of Dihydropyrimidin‐4(1 <i>H</i> )‐One Scaffold Employing <i>N</i> ‐Heterocyclic Carbene Catalysis (Adv. Synth. Catal. 23/2025)
Year: 2025
Type: article
Language: en
Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Authors and affiliations:
raw_author_name: Adam Cieśliński
raw_affiliation_strings: Institute of Organic Chemistry Lodz University of Technology  Łódź Poland
raw_author_name: Artur Przydacz
raw_affiliation_strings: Institute of Organic Chemistry Lodz University of Technology  Łódź Poland
raw_author_name: Anna Skrzyńska
raw_affiliation_strings: Institute of Organic Chemistry Lodz University of Technology  Łódź Poland
raw_author_name: Łukasz Albrecht
raw_affiliation_strings: Institute of Organic Chemistry Lodz University of Technology  Łódź Poland