Long-Term Effectiveness of Tenofovir Alafenamide Versus Entecavir in Treatment-Naive Chronic Hepatitis B: A Real-World Evidence from the Global Alliance for the Study of Hepatitis B Virus
Year: 2025
Type: article
Language: en
Topic: Hepatitis B Virus Studies
Authors and affiliations:
raw_author_name: Jie Li
raw_affiliation_strings: Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Joanne Kimiko Liu
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, California, USA;
Division of Gastroenterology and Hepatology, University of Washington, Seattle, Washington, USA;
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
Division of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA
raw_author_name: Angela Chau
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, California, USA;
Weill Cornell Medicine, New York, New York, USA;
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
Weill Cornell Medicine, New York, New York, USA
raw_author_name: Sovann Linden
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, California, USA;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Pei-Chien Tsai
raw_affiliation_strings: Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Akito Nozaki
raw_affiliation_strings: Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan;
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
raw_author_name: Philip Vutien
raw_affiliation_strings: Division of Gastroenterology and Hepatology, University of Washington, Seattle, Washington, USA;
Division of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA
raw_author_name: Haruki Uojima
raw_affiliation_strings: Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan;
Genome Medical Sciences Project, Research Institute, National Center for Global Health and Medicine, Sagamihara, Japan;
Genome Medical Sciences Project, Research Institute, National Center for Global Health and Medicine, Sagamihara, Japan
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan
raw_author_name: Hidenori Toyoda
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Takashi Honda
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Huy Trinh
raw_affiliation_strings: San Jose Gastroenterology, San Jose, California, USA;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
San Jose Gastroenterology, San Jose, CA, USA
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Hiroshi Abe
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Chiba, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
raw_author_name: Toru Ishikawa
raw_affiliation_strings: Department of Gastroenterology, Saiseikai Niigata Hospital, Niigata, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Division of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA
raw_author_name: Masanori Atsukawa
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Tsunamasa Watanabe
raw_affiliation_strings: Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
raw_author_name: Kunihiko Tsuji
raw_affiliation_strings: Center for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan;
Division of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Daniel Q. Huang
raw_affiliation_strings: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
Division of Gastroenterology and Hepatology, National University Hospital, Singapore, Singapore;
Genome Medical Sciences Project, Research Institute, National Center for Global Health and Medicine, Sagamihara, Japan
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Koichi Takaguchi
raw_affiliation_strings: Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan
raw_author_name: Ei Itobayashi
raw_affiliation_strings: Department of Gastroenterology, Asahi General Hospital, Chiba, Japan;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Sebastián Marciano
raw_affiliation_strings: Jefe de Hepatología–Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;
Jefe de la Sub-secretaria de Investigación Clínica–Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;
Jefe de la Sub-secretaria de Investigación Clínica - Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Fajuan Rui
raw_affiliation_strings: Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Wenjing Ni
raw_affiliation_strings: Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Hirokazu Takahashi
raw_affiliation_strings: Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga, Japan;
Liver Center, Saga University Hospital, Saga, Japan;
Division of Metabolism and endocrinology, Faculty of Medicine, Saga University, Saga, Japan
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Wan-Long Chuang
raw_affiliation_strings: Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Chia-Yen Dai
raw_affiliation_strings: Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan
Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Jee-Fu Huang
raw_affiliation_strings: Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan;
Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Chung-Feng Huang
raw_affiliation_strings: Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan
Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Ming-Lun Yeh
raw_affiliation_strings: Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan;
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Yixuan Zhu
raw_affiliation_strings: Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Norio Itokawa
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Ritsuzo Kozuka
raw_affiliation_strings: Department of Hepatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan;
Department of Hepatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Kaori Inoue
raw_affiliation_strings: Liver Center, Saga University Hospital, Saga, Japan;
Division of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Tomonori Senoh
raw_affiliation_strings: Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan;
Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Mayumi Maeda
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, California, USA;
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
raw_author_name: Takanori Ito
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Manabu Morimoto
raw_affiliation_strings: Division of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, Yokohama, Japan;
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan;
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
raw_author_name: Ramsey Cheung
raw_affiliation_strings: Gastroenterology and Hepatology, The Palo Alto Veterans Affairs Health Care System, Palo Alto, California, USA;
Genome Medical Sciences Project, Research Institute, National Center for Global Health and Medicine, Sagamihara, Japan
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Adrian Gadano
raw_affiliation_strings: Jefe de Hepatología–Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;
Jefe de la Sub-secretaria de Investigación Clínica–Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Jefe de la Sub-secretaria de Investigación Clínica - Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
raw_author_name: Masaru Enomoto
raw_affiliation_strings: Department of Hepatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan;
Department of Transfusion Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan;
Division of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
Department of Transfusion Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
raw_author_name: Yasuhito Tanaka
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;
Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA
raw_author_name: Seng Gee Lim
raw_affiliation_strings: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;
Division of Gastroenterology and Hepatology, National University Hospital, Singapore, Singapore;
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan
Genome Medical Sciences Project, Research Institute, National Center for Global Health and Medicine, Sagamihara, Japan
raw_author_name: Chao Wu
raw_affiliation_strings: Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China;
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China
Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
raw_author_name: Ming-Lung Yu
raw_affiliation_strings: Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan;
School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan
raw_author_name: Mindie H. Nguyen
raw_affiliation_strings: Department of Epidemiology and Population Health, Stanford University, Stanford, California, USA
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, California, USA;
Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA