Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations
Year: 2025
Type: article
Language: en
Topic: Acute Lymphoblastic Leukemia research
Authors and affiliations:
raw_author_name: Hye Sun Kuehn
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
NIH, Bethesda, Maryland, United States
raw_author_name: Agustin A. Gil Silva
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
Clinical Center, NIH, Bethesda, Maryland, United States
raw_author_name: Natchanun Klangkalya
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
2Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Clinical Center, NIH, Bethesda, Maryland, United States
raw_author_name: Ana Esteve-Sole
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
Clinical Center, NIH, Bethesda, Maryland, United States
raw_author_name: Shubham Goel
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
Clinical Center, NIH, Bethesda, Maryland, United States
raw_author_name: Julie E. Niemela
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
NIH Clinical Center, Bethesda, Maryland, United States
raw_author_name: Jennifer L. Stoddard
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
NIH, Bethesda, Maryland, United States
raw_author_name: Hey Chong
raw_affiliation_strings: 3Division of Allergy and Immunology, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA
UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
raw_author_name: Kelli Williams
raw_affiliation_strings: 4Division of Pediatric Pulmonology, Allergy and Immunology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC
Medical University of South Carolina, Charleston, South Carolina, United States
raw_author_name: Winnie Ip
raw_affiliation_strings: 5Molecular and Cellular Immunology, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
Infection, Immunity and Inflammation Theme, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
raw_author_name: Mario Framil Seoane
raw_affiliation_strings: 6Immunology Department, Hospital Clínic, Barcelona, Spain
s, Spain
raw_author_name: Sathish Kumar Loganathan
raw_affiliation_strings: 7Department of Pediatrics, Christian Medical College and Hospital, Vellore, India
India
raw_author_name: Ariharan Anantharachagan
raw_affiliation_strings: 8Department of Allergy and Clinical Immunology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom
United Kingdom
raw_author_name: Ana García-Soidán
raw_affiliation_strings: 9Department of Immunology, Fundacion Instituto de Investigaciones Sanitarias de Canarias, University Hospital of Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
Spain
raw_author_name: Serena Shaffren
raw_affiliation_strings: 10Johns Hopkins All Children's Hospital, St. Petersburg, FL
11Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL
12Division of Allergy and Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St. Petersburg, FL
United States
raw_author_name: Constance Bindernagel
raw_affiliation_strings: 11Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL
12Division of Allergy and Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St. Petersburg, FL
United States
raw_author_name: Philip Mendez
raw_affiliation_strings: 11Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL
12Division of Allergy and Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St. Petersburg, FL
United States
raw_author_name: Rahim Z. Miller
raw_affiliation_strings: 11Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL
12Division of Allergy and Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St. Petersburg, FL
United States
raw_author_name: Hassan Abolhassani
raw_affiliation_strings: 13Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
14Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
raw_author_name: David P. Hoytema van Konijnenburg
raw_affiliation_strings: 15Division of Immunology, Boston Children’s Hospital and Harvard Medical School, Boston, MA
United States
raw_author_name: Ashley V. Geerlinks
raw_affiliation_strings: 16Division of Pediatric Hematology and Oncology, Western University and Children’s Hospital, London Health Sciences Centre, London, Ontario, Canada
Children's Hospital, London Health Sciences Centre, Western University, London, Ontario, Canada
raw_author_name: Diana Cabanillas
raw_affiliation_strings: 17Unidad de Inmunología, Hospital de Niños Sor María Ludovica, La Plata, Argentina
Argentina
raw_author_name: Evelien Zonneveld-Huijssoon
raw_affiliation_strings: 18Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
University Medical Center Groningen
raw_author_name: Abraham Rutgers
raw_affiliation_strings: 19Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
University Medical Center Groningen, Groningen, Netherlands
raw_author_name: Stuart Tangye
raw_affiliation_strings: 20Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
21School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, Kensington, NSW, Australia
22Clinical Immunogenomics Research Consortium Australasia, Darlinghurst, NSW, Australia
Garvan Institute of Medical Research, Sydney, Australia
raw_author_name: Cindy Ma
raw_affiliation_strings: 20Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
21School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales Sydney, Kensington, NSW, Australia
22Clinical Immunogenomics Research Consortium Australasia, Darlinghurst, NSW, Australia
Garvan Institute of Medical Research, Darlinghurst, Australia
raw_author_name: Alice Grey
raw_affiliation_strings: 23Department of Clinical Immunology and Allergy, Royal Prince Alfred Hospital, Sydney, Australia
24Clinical Immunology and Allergy, Westmead Hospital, Sydney, Australia
Australia
raw_author_name: Patrick O'Young
raw_affiliation_strings: 20Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
22Clinical Immunogenomics Research Consortium Australasia, Darlinghurst, NSW, Australia
Garvan Institute of Medical Research, Darlinghurst, Australia
raw_author_name: Juan Carlos Aldave Becerra
raw_affiliation_strings: 25Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
Edgardo Rebagliati Martins National Hospital, Lima, Peru
raw_author_name: Jonathan J. Lyons
raw_affiliation_strings: 26Division of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA
27Veterans Affairs San Diego Healthcare System, La Jolla, CA
United States
raw_author_name: Andrew A. White
raw_affiliation_strings: 28Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, CA
Scripps Clinic Medical Group, San Diego, California, United States
raw_author_name: Michael Claiborne
raw_affiliation_strings: 28Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, CA
United States
raw_author_name: Mohammad-Ali Doroudchi
raw_affiliation_strings: 29Modena Health, La Jolla, CA
United States
raw_author_name: Brian D. Modena
raw_affiliation_strings: 29Modena Health, La Jolla, CA
United States
raw_author_name: Joshua D. Milner
raw_affiliation_strings: 30Department of Pediatrics, Columbia University Irving Medical Center, New York, NY
Division of Allergy, Immunology and Rheumatology, Columbia University, Morgan Stanley Children's Hospital, New York, New York, United States
raw_author_name: Xavier Solanich
raw_affiliation_strings: 31Internal Medicine Department, University Hospital of Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain
raw_author_name: João Farela Neves
raw_affiliation_strings: 32Primary Immunodeficiencies Unit, Hospital Dona Estefânia, Unidade Local de Saúde São José, Lisbon, Portugal
33Comprehensive Health Research Center, NOVA Medical School, Lisbon, Portugal
Portugal
raw_author_name: Craig D. Platt
raw_affiliation_strings: 15Division of Immunology, Boston Children’s Hospital and Harvard Medical School, Boston, MA
Boston Children's Hospital, Boston, Massachusetts, United States
raw_author_name: Lennart Hammarström
raw_affiliation_strings: 13Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Karolinska Institutet, Stockholm, Sweden
raw_author_name: John M. Routes
raw_affiliation_strings: 34Division of Asthma, Allergy and Clinical Immunology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
Medical College of Wisconsin, milwaukee, Wisconsin, United States
raw_author_name: James Verbsky
raw_affiliation_strings: 35Division of Pediatric Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
raw_author_name: Manish J. Butte
raw_affiliation_strings: 36University of California Los Angeles, Los Angeles, CA
UCLA, Los Angeles, California, United States
raw_author_name: Harry Lesmana
raw_affiliation_strings: 37Department of Medical Genetics and Genomics, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH
38Department of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH
Cleveland Clinic, Cleveland, Ohio, United States
raw_author_name: William J. H. Griffiths
raw_affiliation_strings: 39Liver Unit, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
United Kingdom
raw_author_name: Dinakantha Kumararatne
raw_affiliation_strings: 40Department of Clinical Immunology, Addenbrooke’s Hospital, Cambridge, United Kingdom
Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital,, Cambridge, United Kingdom
raw_author_name: Fabian Hauck
raw_affiliation_strings: 41Division of Pediatric Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children’s Hospital, Ludwig Maximilian University of Munich, Munich, Germany
Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany
raw_author_name: Luis M. Allende
raw_affiliation_strings: 42Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain
Hospital Universitario 12 de Octubre. imas12, Madrid, Spain
raw_author_name: Carlos Rodríguez-Gallego
raw_affiliation_strings: 43Department of Medical and Surgical Sciences, School of Medicine, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
44Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain
45Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
9Department of Immunology, Fundacion Instituto de Investigaciones Sanitarias de Canarias, University Hospital of Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
Gran Canaria Dr. Negrín University Hospital, LAS PALMAS DE GRAN CANARIA, Spain
raw_author_name: Reem Elfeky
raw_affiliation_strings: 46Department of Clinical Immunology, Royal Free Hospital, London, United Kingdom
LONDON, ENG, United Kingdom
raw_author_name: Tamar Rubin
raw_affiliation_strings: 47Section of Pediatric Clinical Immunology and Allergy, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
University of Manitoba, Winnipeg, Canada
raw_author_name: Kaan Boztug
raw_affiliation_strings: 48St. Anna Children’s Cancer Research Institute, Vienna, Austria
49Clinic for Pediatric Immunology and Rheumatology, Center for Pediatrics and Adolescent Medicine, University Hospital Bonn, Bonn, Germany
St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria
raw_author_name: Thomas A. Fleisher
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
NIH, Bethesda, Maryland, United States
raw_author_name: Sergio D. Rosenzweig
raw_affiliation_strings: 1Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
Clinical Center, NIH, Bethesda, Maryland, United States