Targeting ATR offers multifaceted treatment strategies involving RAD51-mediated compensatory DNA repair in bladder cancer
Year: 2025
Type: article
Language: en
Topic: DNA Repair Mechanisms
Authors and affiliations:
raw_author_name: Julia Pannhausen
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
raw_author_name: Ahmed A. Chughtai
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Department of Radiation Oncology, Uniklinik RWTH Aachen, Aachen, 52074, Germany
raw_author_name: Cem-Louis Yüce
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
raw_author_name: Michael K. Melzer
raw_affiliation_strings: Department of Urology, Ulm University Hospital, Ulm, 89081, Germany
Institute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, 89081, Germany
raw_author_name: Yanchun Ma
raw_affiliation_strings: Department of Urology, Ulm University Hospital, Ulm, 89081, Germany
Institute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, 89081, Germany
raw_author_name: Lancelot Seillier
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
raw_author_name: Emiel P. C. van der Vorst
raw_affiliation_strings: Department of Internal Medicine I, Aachen-Maastricht Institute for Cardio-Renal Disease (AMICARE), Institute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, Aachen, 52074, Germany
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität Munich, Munich, 80336, Germany
raw_author_name: Geoffroy Andrieux
raw_affiliation_strings: Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center, University of Freiburg, University of Freiburg, Freiburg, 79110, Germany
raw_author_name: Julia Wirtz
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
raw_author_name: Sophie Leypold
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
raw_author_name: Mark P. Kühnel
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
raw_author_name: Per Hoffmann
raw_affiliation_strings: Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, 53127, Germany
raw_author_name: Stefanie Heilmann-Heimbach
raw_affiliation_strings: Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, 53127, Germany
raw_author_name: Melanie Boerries
raw_affiliation_strings: German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ, Medical Center - University of Freiburg, Freiburg, 79110, Germany
Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center, University of Freiburg, University of Freiburg, Freiburg, 79110, Germany
raw_author_name: Alexander Kleger
raw_affiliation_strings: Core Facility Organoids, Ulm University Hospital, Ulm, 89081, Germany
Institute for Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, 89081, Germany
Section for Interdisciplinary Pancreatology, Clinic for Internal Medicine I, Ulm University Hospital, Ulm, 89081, Germany
raw_author_name: Matthias Saar
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Department of Urology and Pediatric Urology, Uniklinik RWTH Aachen, 52074, Aachen, Germany
raw_author_name: Michael J. Eble
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
Department of Radiation Oncology, Uniklinik RWTH Aachen, Aachen, 52074, Germany
raw_author_name: Danny D. Jonigk
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany
German Center for Lung Research, DZL, BREATH, Hanover, 30625, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
raw_author_name: Nadine T. Gaisa
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany. nadine.gaisa@uniklinik-ulm.de
Institute of Pathology, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany. nadine.gaisa@uniklinik-ulm.de
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany. nadine.gaisa@uniklinik-ulm.de
Institute of Pathology, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
raw_author_name: Michael Rose
raw_affiliation_strings: Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany. mrose@ukaachen.de
Institute of Pathology, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany. mrose@ukaachen.de
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany. mrose@ukaachen.de
Institute of Pathology, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm, 89081, Germany
Institute of Pathology, Uniklinik RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany
Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, 52074, Germany