A Novel Class of Orally Bioavailable Phenylglycine–Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action
Year: 2025
Type: article
Language: en
Topic: Organoboron and organosilicon chemistry
Authors and affiliations:
raw_author_name: Mokhitli Morake
raw_affiliation_strings: Department of Chemistry
University of Cape Town
raw_author_name: Dale Taylor
raw_affiliation_strings: Drug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine (IDM)
University of Cape Town
raw_author_name: Dina Coertzen
raw_affiliation_strings: Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa
raw_author_name: Mathew Njoroge
raw_affiliation_strings: Drug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine (IDM)
University of Cape Town
raw_author_name: Liezl Krugmann
raw_affiliation_strings: Drug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine (IDM)
University of Cape Town
raw_author_name: Meta Leshabane
raw_affiliation_strings: Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa
raw_author_name: Shanté da Rocha
raw_affiliation_strings: Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa
raw_author_name: Tarrick Qahash
raw_affiliation_strings: Department of Biochemistry and Molecular Biology
Huck Center for Malaria Research
The Pennsylvania State University
raw_author_name: Gareth Girling
raw_affiliation_strings: Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom
raw_author_name: Rachael Coyle
raw_affiliation_strings: Biological Chemistry and Drug Discovery, School of Life Sciences
University of Dundee
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom
raw_author_name: Marcus C. S. Lee
raw_affiliation_strings: Biological Chemistry and Drug Discovery, School of Life Sciences
University of Dundee
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom
raw_author_name: Sergio Wittlin
raw_affiliation_strings: Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland
University of Basel
raw_author_name: Manuel Llinás
raw_affiliation_strings: Department of Biochemistry and Molecular Biology
Department of Chemistry
Huck Center for Malaria Research
The Pennsylvania State University
raw_author_name: Lyn-Marie Birkholtz
raw_affiliation_strings: Department of Biochemistry
Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa
Stellenbosch University
raw_author_name: Gregory S. Basarab
raw_affiliation_strings: Drug Discovery and Development Centre (H3D), Department of Chemistry
University of Cape Town
raw_author_name: Kelly Chibale
raw_affiliation_strings: Department of Chemistry
Drug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine (IDM)
Institute of Infectious Disease and Molecular Medicine
South African Medical Research Council Drug Discovery and Development Research Unit
University of Cape Town