The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer
Year: 2025
Type: article
Language: en
Topic: Prostate Cancer Treatment and Research
Authors and affiliations:
raw_author_name: Srushti Kittane
raw_affiliation_strings: 1Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland
2Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University Baltimore United States
raw_author_name: Erik Ladewig
raw_affiliation_strings: 3Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center New York, NY United States
raw_author_name: Taibo Li
raw_affiliation_strings: 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland
5McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins Medicine Baltimore United States
raw_author_name: Jillian R. Love
raw_affiliation_strings: 6Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland
École Polytechnique Fédérale de Lausanne Lausanne Switzerland
raw_author_name: Ryan Blawski
raw_affiliation_strings: 2Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins Medicine United States
raw_author_name: Yangzhenyu Gao
raw_affiliation_strings: 7Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Johns Hopkins University United States
raw_author_name: Amaia Arruabarrena-Aristorena
raw_affiliation_strings: 8Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Bilbao, Spain
9Ikerbasque, Basque Foundation for Science, Bilbao, Spain
University of the Basque Country Leioa, Vizcaya Spain
raw_author_name: Peihua Zhao
raw_affiliation_strings: 10Department of Oncology, KU Leuven, Leuven, Belgium
VIB-KU Leuven Center for Cancer Biology Leuven Belgium
raw_author_name: Susan L. Dalrymple
raw_affiliation_strings: 2Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University Baltimore, MD United States
raw_author_name: Huayang Liu
raw_affiliation_strings: 11AstraZeneca, Gaithersburg, Maryland
AstraZeneca (United States) United States
raw_author_name: Xinyu Guo
raw_affiliation_strings: 7Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Johns Hopkins Bloomberg School of Public Health Baltimore, MD United States
raw_author_name: Mirna Sallaku
raw_affiliation_strings: 12Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center United States
raw_author_name: Nachiket Kelkar
raw_affiliation_strings: 1Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland
2Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins Medicine United States
raw_author_name: Liliana Garcia-Martinez
raw_affiliation_strings: 13Sylvester Comprehensive Cancer Center, Miami, Florida
University of Miami Miller School of Medicine Miami United States
raw_author_name: Javier Carmona Sanz
raw_affiliation_strings: 12Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York
Vall d'Hebron Institute of Oncology United States
raw_author_name: Wanlu Chen
raw_affiliation_strings: 7Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Johns Hopkins University United States
raw_author_name: Candice Stoudmann
raw_affiliation_strings: 6Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland
Formation Continue UNIL-EPFL Switzerland
raw_author_name: Laura Baldino
raw_affiliation_strings: 12Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center New York, NY United States
raw_author_name: Milad Razavi-Mohseni
raw_affiliation_strings: 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland
5McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University Baltimore, MD United States
raw_author_name: Ingrid Kalemi
raw_affiliation_strings: 2Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins Medicine United States
raw_author_name: Michael A. Beer
raw_affiliation_strings: 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland
5McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University Baltimore United States
raw_author_name: Pau Castel
raw_affiliation_strings: 14Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York
NYU Langone's Laura and Isaac Perlmutter Cancer Center New York United States
raw_author_name: W. Nathaniel Brennen
raw_affiliation_strings: 2Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins Medicine Baltimore, MD United States
raw_author_name: Maurizio Scaltriti
raw_affiliation_strings: 11AstraZeneca, Gaithersburg, Maryland
AstraZeneca (United States) New York, NY United States
raw_author_name: Lluis Morey
raw_affiliation_strings: 13Sylvester Comprehensive Cancer Center, Miami, Florida
University of Miami Miller School of Medicine Miami United States
raw_author_name: Emiliano Cocco
raw_affiliation_strings: 15Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, Florida
University of Miami Hospital United States
raw_author_name: Hongkai Ji
raw_affiliation_strings: 7Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Johns Hopkins Bloomberg School of Public Health Baltimore, MD United States
raw_author_name: Ho Man Chan
raw_affiliation_strings: 11AstraZeneca, Gaithersburg, Maryland
AstraZeneca (United States) United States
raw_author_name: Alexis Battle
raw_affiliation_strings: 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland
5McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University United States
raw_author_name: Christina S. Leslie
raw_affiliation_strings: 3Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center New York, NY United States
raw_author_name: Wouter R. Karthaus
raw_affiliation_strings: 6Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland
Swiss Institute for Experimental Cancer Research (ISREC) Lausanne Switzerland
raw_author_name: Eneda Toska
raw_affiliation_strings: 1Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland
2Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University Baltimore United States