Toxicophore-informed machine learning integrating Tox21 assay readouts for organ system–specific carcinogenicity prediction
Year: 2025
Type: article
Language: en
Topic: Computational Drug Discovery Methods
Authors and affiliations:
raw_author_name: Chi-Yun Chen
raw_affiliation_strings: Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL, 32611, United States
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL 32611, United States
raw_author_name: Wei-Chun Chou
raw_affiliation_strings: Department of Environmental Sciences, College of Natural & Agricultural Sciences, University of California, Riverside, CA, 92521, United States; Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, United States
Department of Environmental Sciences, College of Natural & Agricultural Sciences, University of California, Riverside, CA 92521, United States; Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, United States
raw_author_name: Venkata Nithin Kamineni
raw_affiliation_strings: Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL, 32611, United States
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL 32611, United States
raw_author_name: Pei-Yu Wu
raw_affiliation_strings: Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL, 32611, United States
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL 32611, United States
raw_author_name: Zhicheng Zhang
raw_affiliation_strings: Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL, 32611, United States
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL 32611, United States
raw_author_name: Xue Wu
raw_affiliation_strings: Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL, 32611, United States
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL 32611, United States
raw_author_name: Chris D. Vulpe
raw_affiliation_strings: Center for Environmental and Human Toxicology, University of Florida, FL, 32611, United States; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, United States
Center for Environmental and Human Toxicology, University of Florida, FL 32611, United States; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, United States
raw_author_name: Zhoumeng Lin
raw_affiliation_strings: Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL, 32611, United States. Electronic address: linzhoumeng@ufl.edu
Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, United States; Center for Environmental and Human Toxicology, University of Florida, FL 32611, United States. Electronic address: linzhoumeng@ufl.edu