Efficacy and safety of L-oxiracetam on cognitive function in patients with traumatic brain injury: a multicentre, randomised, double-blind, phase 3 clinical trial
Year: 2025
Type: article
Language: en
Topic: Traumatic Brain Injury and Neurovascular Disturbances
Authors and affiliations:
raw_author_name: Tao Liu
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Jiao Wang
raw_affiliation_strings: Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
National Clinical Research Centre for Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
raw_author_name: Zhihao Zhao
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Department of Neurosurgery, Jieyang People's Hospital, Guangdong, China
raw_author_name: Weiwei Jiang
raw_affiliation_strings: Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
raw_author_name: Minzhi Zhang
raw_affiliation_strings: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
National Clinical Research Centre for Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
raw_author_name: Yunhu Yu
raw_affiliation_strings: Department of Clinical Research Centre for Neurological Disease, The People's Hospital of Honghuagang District of ZunYi, Guizhou, China
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
raw_author_name: Yang Liu
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
raw_author_name: Mingqi Liu
raw_affiliation_strings: Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
raw_author_name: Linan Chen
raw_affiliation_strings: The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
Department of Clinical Research Centre for Neurological Disease, The People's Hospital of Honghuagang District of ZunYi, Guizhou, China
raw_author_name: Hengzhu Zhang
raw_affiliation_strings: Department of Neurosurgery, Subei People's Hospital, Jiangsu, China
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
raw_author_name: Yingbiao Hong
raw_affiliation_strings: Department of Neurosurgery, Jieyang People's Hospital, Guangdong, China
Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China
raw_author_name: Bohe Li
raw_affiliation_strings: Department of Neurosurgery, Yichun People's Hospital, Jiangxi, China
The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
raw_author_name: Rutong Yu
raw_affiliation_strings: Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Department of Neurosurgery, Subei People's Hospital, Jiangsu, China
raw_author_name: Hongming Ji
raw_affiliation_strings: Department of Neurosurgery, Shanxi Provincial People's Hospital, Shanxi, China
Department of Neurosurgery, Jieyang People's Hospital, Guangdong, China
raw_author_name: Liang Mi
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Department of Neurosurgery, Yichun People's Hospital, Jiangxi, China
raw_author_name: Biao Zhao
raw_affiliation_strings: Department of Neurosurgery, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, China
Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
raw_author_name: Chuanxiang Lv
raw_affiliation_strings: Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China
Department of Neurosurgery, Shanxi Provincial People's Hospital, Shanxi, China
raw_author_name: Chenglong Liu
raw_affiliation_strings: Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
raw_author_name: Jianning Zhang
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China. jianningzhang@hotmail.com
Department of Neurosurgery, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, China
raw_author_name: Rongcai Jiang
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China. jiang116216@163.com
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. jiang116216@163.com
Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China
raw_author_name: for the LOCATE Trial Investigators
raw_affiliation_strings: Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
raw_author_name: Tao Liu
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
raw_author_name: Jiao Wang
raw_affiliation_strings: Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
National Clinical Research Centre for Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
raw_author_name: Zhihao Zhao
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Yan'an Hospital of Kunming City, Kunming, China
raw_author_name: Weiwei Jiang
raw_affiliation_strings: Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Dazhu County People's Hospital, Dazhou, China
raw_author_name: Minzhi Zhang
raw_affiliation_strings: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
The People's Hospital of Yuechi County, Guang'an, China
raw_author_name: Yunhu Yu
raw_affiliation_strings: Department of Clinical Research Centre for Neurological Disease, The People's Hospital of Honghuagang District of ZunYi, Guizhou, China
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Yan'an University Xianyang Hospital, Xianyang, China
raw_author_name: Yang Liu
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
Pu'er City People's Hospital, Pu'er, China
raw_author_name: Mingqi Liu
raw_affiliation_strings: Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China
Panzhihua Central Hospital, Panzhihua, China
raw_author_name: Linan Chen
raw_affiliation_strings: The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
First Affiliated Hospital of Anhui Medical University North District, Hefei, China
raw_author_name: Hengzhu Zhang
raw_affiliation_strings: Department of Neurosurgery, Subei People's Hospital, Jiangsu, China
The First People's Hospital of Nanning, Nanning, China
raw_author_name: Yingbiao Hong
raw_affiliation_strings: Department of Neurosurgery, Jieyang People's Hospital, Guangdong, China
Huai'an NO.1 People's Hospital of Nanjing Medical University, Huai'an, China
raw_author_name: Bohe Li
raw_affiliation_strings: Department of Neurosurgery, Yichun People's Hospital, Jiangxi, China
Yangquan Coal Industry General Hospital, Yangquan, China
raw_author_name: Rutong Yu
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The First People's Hospital of Jinzhong, Jinzhong, China
raw_author_name: Hongming Ji
raw_affiliation_strings: Department of Neurosurgery, Shanxi Provincial People's Hospital, Shanxi, China
The First People's Hospital of Shenyang, Shenyang, China
raw_author_name: Liang Mi
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
The First People's Hospital of Lianyungang, Lianyungang, China
raw_author_name: Biao Zhao
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The Second Affiliated Hospital of Nanchang University, Nanchang, China
raw_author_name: Chuanxiang Lv
raw_affiliation_strings: Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China
The First People's Hospital of Changzhou, Changzhou, China
raw_author_name: Chenglong Liu
raw_affiliation_strings: Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
The First People's Hospital of Shenyang, Shenyang, China
raw_author_name: Jianning Zhang
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China. jianningzhang@hotmail.com
Inner Mongolia Autonomous Region People's Hospital, Hohhot, China
raw_author_name: Rongcai Jiang
raw_affiliation_strings: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China. jiang116216@163.com
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. jiang116216@163.com
Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou, China
raw_author_name: Taikun Tang
raw_affiliation_strings: Yan’an Hospital of Kunming City, Kunming, China
Haikou People's Hospital, Haikou, China
raw_author_name: Sheng Zhu
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Liuzhou Worker's Hospital, Liuzhou, China
raw_author_name: Hangang Jiang
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Taizhou First People's Hospital, Taizhou, China
raw_author_name: Zengqiang Liu
raw_affiliation_strings: Yan’an University Xianyang Hospital, Xianyang, China
Ganzhou People's Hospital, Ganzhou, China
raw_author_name: Xingchang Li
raw_affiliation_strings: Pu’er City People’s Hospital, Pu’er, China
Beijing Chaoyang Hospital, Beijing, China
raw_author_name: Jianbo Wei
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First Affiliated Hospital of Gannan Medical University, Ganzhou, China
raw_author_name: Tao Jiang
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Hainan Third People's Hospital, Sanya, China
raw_author_name: Feng Wei
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Suzhou Kowloon Hospital, Suzhou, China
raw_author_name: Lianshu Ding
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Affiliated Hospital of Nantong University, Nantong, China
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Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
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The First People's Hospital of Changde City, Changde, China
raw_author_name: Li Li
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Linfen People's Hospital, Linfen, China
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Guilin People's Hospital, Guilin, China
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First Affiliated Hospital of Ningbo University, Ningbo, China
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Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
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The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
raw_author_name: Ruijian Zhang
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Huizhou Central People's Hospital, Huizhou, China
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Zhejiang Provincial People's Hospital, Hangzhou, China
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The First Affiliated Hospital of Nanchang University, Nanchang, China
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The Second Hospital of Tianjin Medical University, Tianjin, China
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raw_author_name: Zejun Chen
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raw_author_name: Tao Mei
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raw_author_name: Jianrong Liang
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raw_author_name: Bin Li
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raw_author_name: Xiang Gao
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raw_author_name: Bo Fan
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raw_author_name: Lin Lou
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