Long-term oral glucocerebrosidase activator reduces soluble α-synuclein oligomer accumulation in Parkinsonian LRRK2 mutant mouse brain
Year: 2025
Type: article
Language: en
Topic: Parkinson's Disease Mechanisms and Treatments
Authors and affiliations:
raw_author_name: Zoe Yuen-Kiu Choi
raw_affiliation_strings: Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
raw_author_name: Huifang Liu
raw_affiliation_strings: Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
raw_author_name: Eunice Eun-Seo Chang
raw_affiliation_strings: Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
raw_author_name: Shirley Yin-Yu Pang
raw_affiliation_strings: Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong SAR, China
raw_author_name: Ivy Lingyi Luo
raw_affiliation_strings: Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
raw_author_name: Yuefei Ruan
raw_affiliation_strings: State Key Laboratory of Marine Environmental Health (SKLMEH) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China
raw_author_name: Qi Wang
raw_affiliation_strings: State Key Laboratory of Marine Environmental Health (SKLMEH) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China
raw_author_name: Yasine Malki
raw_affiliation_strings: Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong SAR, China
raw_author_name: Steffi Xi-Yue Zhang
raw_affiliation_strings: Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong SAR, China
raw_author_name: Kerry Yupeng Weng
raw_affiliation_strings: Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
raw_author_name: Benson Wui-Man Lau
raw_affiliation_strings: Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
raw_author_name: Roy Chun-Laam Ng
raw_affiliation_strings: Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, M13 9PT, United Kingdom
Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance and University of Manchester, Manchester, M13 9PT, United Kingdom
raw_author_name: Zaijun Zhang
raw_affiliation_strings: Guangdong Province Key Laboratory of Pharmacodynamic, Constituents of TCM and New Drugs Research, Institute of New Drug Research, College of Pharmacy, Jinan University, Guangzhou, China
raw_author_name: Shu-Leong Ho
raw_affiliation_strings: Division of Neurology, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong SAR, China
raw_author_name: Philip Wing-Lok Ho
raw_affiliation_strings: Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China. philip-wl.ho@polyu.edu.hk
Mental Health Research Centre (MHRC), PolyU Academy for Interdisciplinary Research, The Hong Kong Polytechnic University, Hong Kong SAR, China. philip-wl.ho@polyu.edu.hk
Research Institute for Smart Ageing (RISA), The Hong Kong Polytechnic University, Hong Kong SAR, China. philip-wl.ho@polyu.edu.hk
State Key Laboratory of Marine Environmental Health (SKLMEH) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, China. philip-wl.ho@polyu.edu.hk
Research Institute for Smart Ageing (RISA), The Hong Kong Polytechnic University, Hong Kong SAR, China