Design, synthesis and biological activity of glycoconjugated ADAMTS5 exosite inhibitors: applications in osteoarthritis and ovarian cancer models
Year: 2025
Type: article
Language: en
Topic: Osteoarthritis Treatment and Mechanisms
Authors and affiliations:
raw_author_name: Doretta Cuffaro
raw_affiliation_strings: Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy
raw_author_name: Sophie Blagg
raw_affiliation_strings: Department of Immunology and Inflammation, Imperial College London, Du Cane Road, London, W12 0NN, UK
raw_author_name: Kazuhiro Yamamoto
raw_affiliation_strings: Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK
Scleroprotein and Leather Research Institute, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, 183-8509, Tokyo, Japan
raw_author_name: Luca Pinzi
raw_affiliation_strings: Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 103, Modena, 41125, Italy
raw_author_name: Rachele Bacchetti
raw_affiliation_strings: School of Biosciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
raw_author_name: Shengnan Yuan
raw_affiliation_strings: School of Biosciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
raw_author_name: Simon Tew
raw_affiliation_strings: Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK
raw_author_name: Paola Campagnolo
raw_affiliation_strings: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Guildford, GU2 7XH, Surrey, UK
Discipline of Clinical Sciences, School of Biosciences, University of Surrey, Guildford, GU2 7XH, Surrey, UK
raw_author_name: Felicia D’Andrea
raw_affiliation_strings: Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy
raw_author_name: Enrico Crispino
raw_affiliation_strings: Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy
raw_author_name: Giulio Rastelli
raw_affiliation_strings: Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 103, Modena, 41125, Italy
raw_author_name: Armando Rossello
raw_affiliation_strings: Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy
raw_author_name: Elena Rainero
raw_affiliation_strings: School of Biosciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
raw_author_name: Elisa Nuti
raw_affiliation_strings: Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy. elisa.nuti@unipi.it
Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy
raw_author_name: Salvatore Santamaria
raw_affiliation_strings: Department of Immunology and Inflammation, Imperial College London, Du Cane Road, London, W12 0NN, UK. s.santamaria@imperial.ac.uk
Discipline of Clinical Sciences, School of Biosciences, University of Surrey, Guildford, GU2 7XH, Surrey, UK. s.santamaria@imperial.ac.uk
Department of Immunology and Inflammation, Imperial College London, Du Cane Road, London, W12 0NN, UK
Discipline of Clinical Sciences, School of Biosciences, University of Surrey, Guildford, GU2 7XH, Surrey, UK