An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells
Year: 2025
Type: article
Language: en
Topic: Liver physiology and pathology
Authors and affiliations:
raw_author_name: Beatrice Anfuso
raw_affiliation_strings: International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy
raw_author_name: Suresh Velnati
raw_affiliation_strings: International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy
raw_author_name: Davide Selvestrel
raw_affiliation_strings: International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy
raw_author_name: Clara Garlant
raw_affiliation_strings: International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste
raw_author_name: Elisa Ferracci
raw_affiliation_strings: Laboratory of Stem Cells and Cancer Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy
raw_author_name: Gabriele Baj
raw_affiliation_strings: Department of Life Sciences, University of Trieste, Trieste, Italy
raw_author_name: Pietro Parisse
raw_affiliation_strings: Elettra-Sincrotrone Trieste, Area Science Park Basovizza, 34149 Trieste, Italy; Institute of Materials (IOM), Italian National Research Council (CNR), Area Science Park Basovizza, 34149 Trieste, Italy
raw_author_name: Diletta Overi
raw_affiliation_strings: Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy
raw_author_name: Rebecca Bertolio
raw_affiliation_strings: International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy
raw_author_name: Roberta Bulla
raw_affiliation_strings: Department of Life Sciences, University of Trieste, Trieste, Italy
raw_author_name: Aurelio Sonzogni
raw_affiliation_strings: Department of Pathology, Policlinico di Monza, Monza, Italy
raw_author_name: Matteo Bramuzzo
raw_affiliation_strings: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy
raw_author_name: Loredana Casalis
raw_affiliation_strings: Elettra-Sincrotrone Trieste, Area Science Park Basovizza, 34149 Trieste, Italy
raw_author_name: Nicholas Cocomello
raw_affiliation_strings: Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
raw_author_name: Francesco Baratta
raw_affiliation_strings: Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
raw_author_name: Maria Del Ben
raw_affiliation_strings: Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
raw_author_name: Pablo Giraudi
raw_affiliation_strings: Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy
raw_author_name: Claudio Tiribelli
raw_affiliation_strings: Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy
raw_author_name: Natalia Rosso
raw_affiliation_strings: Fondazione Italiana Fegato, Area Science Park Basovizza, Trieste, Italy
raw_author_name: Manuela Mastronardi
raw_affiliation_strings: Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy
raw_author_name: Paola Tarchi
raw_affiliation_strings: Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy
raw_author_name: Maurizio Pinamonti
raw_affiliation_strings: Department of Pathology, University Hospital Cattinara, Trieste, Italy
raw_author_name: Fabrizio Zanconati
raw_affiliation_strings: Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste
raw_author_name: Nicolò de Manzini
raw_affiliation_strings: Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy
raw_author_name: Eugenio Gaudio
raw_affiliation_strings: Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy
raw_author_name: Silvia Palmisano
raw_affiliation_strings: Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste; Surgical Clinic Unit, Cattinara Hospital, ASUGI, Strada di Fiume, 447, 34149 Trieste, Italy
raw_author_name: Deborah Bonazza
raw_affiliation_strings: Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste
raw_author_name: Giannino Del Sal
raw_affiliation_strings: International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Life Sciences, University of Trieste, Trieste, Italy; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy
raw_author_name: Guido Carpino
raw_affiliation_strings: Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Roma, Italy
raw_author_name: Fulvio Chiacchiera
raw_affiliation_strings: Laboratory of Stem Cells and Cancer Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy
raw_author_name: Giovanni Sorrentino
raw_affiliation_strings: International Centre for Genetic Engineering and Biotechnology (ICGEB), Area Science Park - Padriciano, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste. Electronic address: giovanni.sorrentino@units.it