BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypes
Year: 2025
Type: article
Language: en
Topic: Amyotrophic Lateral Sclerosis Research
Authors and affiliations:
raw_author_name: Jin-Hui Hor
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Jin Rong Ow
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Winanto Ng
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Boominathan Ramasamy
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Tommaso Tabaglio
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Kimberly Ngee Hui Lim
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Muhammad Ikhsan Bin Muzakar
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Valerie Jing Wen Lim
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Rajasekhar Reddy Gurrampati
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Ravisankar Rajarethinam
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Shyuan T. Ngo
raw_affiliation_strings: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland, Australia 4072
raw_author_name: Venkataramanan Ramadass
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Shuo-Chien Ling
raw_affiliation_strings: Department of Physiology, National University of Singapore, YLL School of Medicine, Singapore 117456, Singapore
National University of Singapore, YLL School of Medicine, Department of Physiology, Singapore 117456
raw_author_name: Manikandan Lakshmanan
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673
raw_author_name: Keng Boon Wee
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore. Electronic address: weekb@a-star.edu.sg
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673. Electronic address: weekb@a-star.edu.sg
raw_author_name: Shi-Yan Ng
raw_affiliation_strings: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Dr, Singapore 138673, Singapore; Department of Physiology, National University of Singapore, YLL School of Medicine, Singapore 117456, Singapore. Electronic address: ng_shi_yan@a-star.edu.sg
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Dr, Singapore 138673; National University of Singapore, YLL School of Medicine, Department of Physiology, Singapore 117456. Electronic address: Ng_Shi_Yan@a-star.edu.sg