The “route cause” of methotrexate-induced brain structure changes in a juvenile mouse model: Comparison of systemic and CNS-targeted chemotherapy
Year: 2025
Type: article
Language: en
Topic: Acute Lymphoblastic Leukemia research
Authors and affiliations:
raw_author_name: Sun Eui Choi
raw_affiliation_strings: Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada. Electronic address: suneui.choi@sickkids.ca
Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada. Electronic address: suneui.choi@sickkids.ca
raw_author_name: Tiffany Ayoub
raw_affiliation_strings: Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
raw_author_name: Gail Lee
raw_affiliation_strings: Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada
raw_author_name: Anne L. Wheeler
raw_affiliation_strings: Neurosciences and Mental Health, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada
Neurosciences and Mental Health, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada
raw_author_name: Sharon L. Guger
raw_affiliation_strings: Department of Psychology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Department of Psychology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada
raw_author_name: Rosanna Weksberg
raw_affiliation_strings: Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Genetics & Genome Biology, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Clinical and Metabolic Genetics, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Molecular Genetics, The University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Institute of Medical Sciences, The University of Toronto, 6 Queen's Park Crescent, Toronto, Ontario M5S 3H2, Canada
Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Genetics & Genome Biology, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Clinical and Metabolic Genetics, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Department of Molecular Genetics, The University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada; Institute of Medical Sciences, The University of Toronto, 6 Queen's Park Crescent, Toronto, Ontario, M5S 3H2, Canada
raw_author_name: Shinya Ito
raw_affiliation_strings: Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Pharmacology and Toxicology, Faculty of Medicine, The University of Toronto, 777 Bay Street, Toronto, Ontario M5G 2C8, Canada
Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Pharmacology and Toxicology, Faculty of Medicine, The University of Toronto, 777 Bay Street, Toronto, Ontario, M5G 2C8, Canada
raw_author_name: Russell J. Schachar
raw_affiliation_strings: Neurosciences and Mental Health, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Psychiatry Research, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Neurosciences and Mental Health, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Department of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Psychiatry Research, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada
raw_author_name: Johann Hitzler
raw_affiliation_strings: Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Development and Stem Cell Biology, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Pediatrics, Faculty of Medicine, The University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Development and Stem Cell Biology, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Department of Pediatrics, Faculty of Medicine, The University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada
raw_author_name: Brian J. Nieman
raw_affiliation_strings: Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada
Translational Medicine, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Mouse Imaging Centre, The Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1×8, Canada; Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario, M5G 0A3, Canada