Targeted BDNF upregulation via upstream open reading frame disruption
Year: 2025
Type: article
Language: en
Topic: Nerve injury and regeneration
Authors and affiliations:
raw_author_name: Ning Feng
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
raw_author_name: Thomas Goedert
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
raw_author_name: Nenad Svrzikapa
raw_affiliation_strings: Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Orfonyx Bio Ltd, BioEscalator, University of Oxford, Innovation Building, Rm 10.15, Roosevelt Drive, Oxford OX3 7FZ, UK
Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK; Orfonyx Bio Ltd, BioEscalator, Innovation Building, Rm 10.15, University of Oxford, Roosevelt Drive, Oxford, OX3 7FZ, UK
raw_author_name: Dongnan Yan
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
raw_author_name: Hans J. Friedrichsen
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
raw_author_name: Britt Hanson
raw_affiliation_strings: Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
raw_author_name: Alicia Ljungdahl
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
raw_author_name: Ruxandra Dafinca
raw_affiliation_strings: Oxford Motor Neuron Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
raw_author_name: Kevin Talbot
raw_affiliation_strings: Oxford Motor Neuron Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
raw_author_name: Stephan J. Sanders
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; New York Genome Center, New York, NY 10013, USA
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; New York Genome Center, New York, NY 10013, USA
raw_author_name: Dhanu Gupta
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
raw_author_name: Mathew J.A. Wood
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; MDUK Oxford Neuromuscular Centre, Oxford OX3 7TY, UK
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK; MDUK Oxford Neuromuscular Centre, UK, OX3 7TY, UK
raw_author_name: Thomas C. Roberts
raw_affiliation_strings: Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; Department of Paediatrics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7TY, UK; MDUK Oxford Neuromuscular Centre, Oxford OX3 7TY, UK. Electronic address: thomas.roberts@idrm.ox.ac.uk
Institute of Developmental and Regenerative Medicine, University of Oxford, IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY, UK; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK; MDUK Oxford Neuromuscular Centre, UK, OX3 7TY, UK. Electronic address: thomas.roberts@idrm.ox.ac.uk