High-throughput screening identifies FDA approved drug mitiglinide as a novel pyroptosis inhibitor and therapeutic agent for osteoarthritis
Year: 2025
Type: article
Language: en
Topic: Inflammasome and immune disorders
Authors and affiliations:
raw_author_name: Hanwen Zhang
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China
raw_author_name: Tanxin Yu
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China
raw_author_name: Nanfang Zhuo
raw_affiliation_strings: Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China; Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
raw_author_name: Zongxin Zhu
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China
raw_author_name: Shihan Lin
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China
raw_author_name: Shiying Zhao
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China
raw_author_name: Huilin Yu
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China
raw_author_name: Youli Zhang
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China
raw_author_name: Aimin Wu
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China. Electronic address: aiminwu@wmu.edu.cn
raw_author_name: Jiangning Wang
raw_affiliation_strings: Department of Orthopaedics, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China. Electronic address: wangjn@bjsjth.cn
raw_author_name: Yifei Zhou
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China. Electronic address: yifeizhou@wmu.edu.cn
raw_author_name: Xiaolei Zhang
raw_affiliation_strings: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325088 Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou 325035 Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325035 Zhejiang Province, China. Electronic address: zhangxiaolei@wmu.edu.cn