DR5 CAR-T cells target melanoma and suppress MDSCs with minimal toxicity
Year: 2025
Type: article
Language: en
Topic: CAR-T cell therapy research
Authors and affiliations:
raw_author_name: Huaishan Wang
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Shujing Liu
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Prithvi Sinha
raw_affiliation_strings: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Fang Liu
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Xiaogang Zhang
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Yeye Guo
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Beatriz Goncalves
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Qiuxiang Zheng
raw_affiliation_strings: Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
raw_author_name: Haiwei Mou
raw_affiliation_strings: Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
raw_author_name: Jingbo Yang
raw_affiliation_strings: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Lili Huang
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Fei Miao
raw_affiliation_strings: Center for Cellular Immunotherapies, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Tingting Zeng
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Giorgos Karakousis
raw_affiliation_strings: Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Alexander C. Huang
raw_affiliation_strings: Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Tara Mitchell
raw_affiliation_strings: Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Ravi Amaravadi
raw_affiliation_strings: Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Lynn Schuchter
raw_affiliation_strings: Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Michael Milone
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Wei Guo
raw_affiliation_strings: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Carl June
raw_affiliation_strings: Center for Cellular Immunotherapies, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Meenhard Herlyn
raw_affiliation_strings: Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
raw_author_name: Yi Fan
raw_affiliation_strings: Center for Cellular Immunotherapies, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
raw_author_name: Xiaowei Xu
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: xug@pennmedicine.upenn.edu