Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera
Year: 2025
Type: article
Language: en
Topic: Endoplasmic Reticulum Stress and Disease
Authors and affiliations:
raw_author_name: Jin Du
raw_affiliation_strings: Department of Research Oncology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Elisia Villemure
raw_affiliation_strings: Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Matthew Johnson
raw_affiliation_strings: Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Caleigh Azumaya
raw_affiliation_strings: Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Catarina J. Gaspar
raw_affiliation_strings: Department of Research Oncology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Scot Marsters
raw_affiliation_strings: Department of Research Oncology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: David Lawrence
raw_affiliation_strings: Department of Research Oncology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Scott Foster
raw_affiliation_strings: Department of Research Oncology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Alexis Rohou
raw_affiliation_strings: Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Tommy K. Cheung
raw_affiliation_strings: Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Christopher M. Rose
raw_affiliation_strings: Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Thomas Garner
raw_affiliation_strings: Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Soo Ro
raw_affiliation_strings: Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Kevin Clark
raw_affiliation_strings: Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Maureen H. Beresini
raw_affiliation_strings: Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Marie-Gabrielle Braun
raw_affiliation_strings: Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Joachim Rudolph
raw_affiliation_strings: Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, USA. joachimr@gene.com
Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Peter Hsu
raw_affiliation_strings: Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA. hsup2@gene.com
Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA
raw_author_name: Avi Ashkenazi
raw_affiliation_strings: Department of Research Oncology, Genentech, Inc., South San Francisco, CA, USA. aa@gene.com
Department of Research Oncology, Genentech, Inc., South San Francisco, CA, USA