Structures of G-protein coupled receptor HCAR3 in complex with selective agonists reveal the basis for ligand recognition and selectivity
Year: 2025
Type: article
Language: en
Topic: Receptor Mechanisms and Signaling
Authors and affiliations:
raw_author_name: Fang Ye
raw_affiliation_strings: Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning, China
Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Zhiyi Zhang
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
The Huanan Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China
raw_author_name: Binghao Zhang
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Xinyu Li
raw_affiliation_strings: Warshel Institute for Computational Biology, School of Medicine, the Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Jiaxi Deng
raw_affiliation_strings: Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning, China
raw_author_name: Qian Miao
raw_affiliation_strings: Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning, China
raw_author_name: Peiruo Ning
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Yunlin Chi
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Geng Chen
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Zhangsong Wu
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Qian Wang
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Lezhi Xu
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Ningjie Gong
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Bangning Cheng
raw_affiliation_strings: Warshel Institute for Computational Biology, School of Medicine, the Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Zhigang Ma
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Chungen Qian
raw_affiliation_strings: Department of Reagent Research and Development, Shenzhen YHLO Biotech Co., Ltd., Shenzhen, Guangdong, China
raw_author_name: Lizhe Zhu
raw_affiliation_strings: Warshel Institute for Computational Biology, School of Medicine, the Chinese University of Hong Kong, Shenzhen, Guangdong, China
raw_author_name: Xin Pan
raw_affiliation_strings: Department of Cardiology, Central Laboratory, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China
raw_author_name: Yang Du
raw_affiliation_strings: Kobilka Institute of Innovative Drug Discovery, The Second Affiliated Hospital, Shenzhen Futian Biomedical Innovation R&D Center, School of Medicine, Chinese University of Hong Kong, Shenzhen, Guangdong, China