CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity
Year: 2025
Type: article
Language: en
Topic: Cancer Immunotherapy and Biomarkers
Authors and affiliations:
raw_author_name: Robert J. Fisher
raw_affiliation_strings: Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA
Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
raw_author_name: Kihyun Park
raw_affiliation_strings: Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA
Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
raw_author_name: Kwangwoon Lee
raw_affiliation_strings: Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women's Hospital, Boston, United States of America
raw_author_name: Katarina Pinjusic
raw_affiliation_strings: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
raw_author_name: Allison Vanasse
raw_affiliation_strings: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
raw_author_name: Christina S. Ennis
raw_affiliation_strings: Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA
Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
raw_author_name: Parisa Farokh
raw_affiliation_strings: Center for Cancer Immunology, Krantz Family Center for Cancer Research, and
Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
raw_author_name: Scott B. Ficaro
raw_affiliation_strings: Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, United States of America
raw_author_name: Jarrod A. Marto
raw_affiliation_strings: Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Cancer Biology, Center for Emergent Drug Targets, and Blais P, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, United States of America
raw_author_name: Hanjie Jiang
raw_affiliation_strings: Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women's Hospital, Boston, United States of America
raw_author_name: Eunju Nam
raw_affiliation_strings: Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA
Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women's Hospital, Boston, United States of America
raw_author_name: Stephanie Stransky
raw_affiliation_strings: Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
raw_author_name: Joseph Duke-Cohan
raw_affiliation_strings: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
raw_author_name: Melis A. Akinci
raw_affiliation_strings: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
raw_author_name: Anupa Geethadevi
raw_affiliation_strings: Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, Maryland, USA
Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
raw_author_name: Eric Raabe
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Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, United States of America
raw_author_name: Ana Fiszbein
raw_affiliation_strings: Department of Biology, Boston University, Boston, Massachusetts, USA
Department of Biology, Boston University, Boston, United States of America
raw_author_name: Shadmehr Demehri
raw_affiliation_strings: Center for Cancer Immunology, Krantz Family Center for Cancer Research, and
Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Center for Cancer Immunology, Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
raw_author_name: Simone Sidoli
raw_affiliation_strings: Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, United States of America
raw_author_name: Chad W. Hicks
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Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America
raw_author_name: Derin B. Keskin
raw_affiliation_strings: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Department of Computer Science, Metropolitan College, Boston University, Boston, Massachusetts, USA
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
raw_author_name: Catherine J. Wu
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Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
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Division of Genetics, Departments of Medicine and Biological Chemistry and , Harvard Medical School and Brigham and Women's Hospital, Boston, United States of America
raw_author_name: Rhoda M. Alani
raw_affiliation_strings: Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA
Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States of America