Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer
Year: 2025
Type: article
Language: en
Topic: Fatty Acid Research and Health
Authors and affiliations:
raw_author_name: Jianjiao Chen
raw_affiliation_strings: Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Guangdong Province, 310014, PR China
Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, PR China
School of Marine Sciences, Sun Yat-sen University, Zhuhai, Guangdong Province, 519082, PR China
raw_author_name: Haishan Cui
raw_affiliation_strings: School of Marine Sciences, Sun Yat-sen University, Zhuhai, Guangdong Province, 519082, PR China
raw_author_name: Xiaolu Wang
raw_affiliation_strings: State Key of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 55N, Neihuanxi Road, Guangzhou, Guangdong Province, 510006, PR China
raw_author_name: Yechun Zeng
raw_affiliation_strings: School of Pharmaceutical Sciences, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, PR China
raw_author_name: Dongyue Pan
raw_affiliation_strings: Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510630, PR China
raw_author_name: Jun Chen
raw_affiliation_strings: Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Guangdong Province, 310014, PR China
Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, PR China
School of Marine Sciences, Sun Yat-sen University, Zhuhai, Guangdong Province, 519082, PR China
raw_author_name: Zhenhua Zhang
raw_affiliation_strings: School of Pharmaceutical Sciences, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, PR China
raw_author_name: Yana An
raw_affiliation_strings: School of Pharmaceutical Sciences, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, PR China
raw_author_name: Zhanfeng Gu
raw_affiliation_strings: Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510630, PR China
raw_author_name: Guodi Cai
raw_affiliation_strings: School of Pharmaceutical Sciences, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, PR China
raw_author_name: Hong Wang
raw_affiliation_strings: School of Pharmaceutical Sciences, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, PR China
raw_author_name: Mengya Yu
raw_affiliation_strings: Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong Province, 510120, PR China
raw_author_name: Bin Yang
raw_affiliation_strings: Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, PR China
raw_author_name: Shengning Zhou
raw_affiliation_strings: Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong Province, 510120, PR China
raw_author_name: Jianan Tan
raw_affiliation_strings: Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong Province, 510120, PR China
raw_author_name: Lan Liu
raw_affiliation_strings: School of Marine Sciences, Sun Yat-sen University, Zhuhai, Guangdong Province, 519082, PR China
raw_author_name: Junjian Wang
raw_affiliation_strings: School of Pharmaceutical Sciences, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, PR China. wangjj87@mail.sysu.edu.cn
School of Pharmaceutical Sciences, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, PR China
raw_author_name: Jing Li
raw_affiliation_strings: School of Marine Sciences, Sun Yat-sen University, Zhuhai, Guangdong Province, 519082, PR China. lijing356@mail.sysu.edu.cn
School of Marine Sciences, Sun Yat-sen University, Zhuhai, Guangdong Province, 519082, PR China
raw_author_name: Fanghai Han
raw_affiliation_strings: Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, PR China. hanfh@mail.sysu.edu.cn
Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong Province, 510120, PR China. hanfh@mail.sysu.edu.cn
Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong Province, 510120, PR China
Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510120, PR China