A novel <i>GRHL2</i> nonsense variant impairs auditory function via a gain-of-function mechanism in autosomal dominant hearing loss
Year: 2025
Type: article
Language: en
Topic: Hearing, Cochlea, Tinnitus, Genetics
Authors and affiliations:
raw_author_name: Ying Ma
raw_affiliation_strings: Beijing Key Laboratory of Hearing Impairment Prevention and Treatment
Key Laboratory of Hearing Science, Ministry of Education
National Clinical Research Center for Otolaryngologic Diseases
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School
State Key Laboratory of Hearing and Balance Science
State Key Laboratory of Hearing and Balance Science, Beijing, China
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
Key Laboratory of Hearing Science, Ministry of Education, Beijing, China
National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
raw_author_name: Sha-sha Huang
raw_affiliation_strings: Beijing Key Laboratory of Hearing Impairment Prevention and Treatment
Key Laboratory of Hearing Science, Ministry of Education
National Clinical Research Center for Otolaryngologic Diseases
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School
State Key Laboratory of Hearing and Balance Science
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
Key Laboratory of Hearing Science, Ministry of Education, Beijing, China
State Key Laboratory of Hearing and Balance Science, Beijing, China
National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
raw_author_name: Ya-hong Li
raw_affiliation_strings: Chinese Institute for Brain Research
Chinese Institute for Brain Research, Beijing, China
raw_author_name: Shi-han Sun
raw_affiliation_strings: Beijing Key Laboratory of Hearing Impairment Prevention and Treatment
Key Laboratory of Hearing Science, Ministry of Education
National Clinical Research Center for Otolaryngologic Diseases
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School
State Key Laboratory of Hearing and Balance Science
Key Laboratory of Hearing Science, Ministry of Education, Beijing, China
Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China
National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
raw_author_name: Jin-yuan Yang
raw_affiliation_strings: Beijing Key Laboratory of Hearing Impairment Prevention and Treatment
Key Laboratory of Hearing Science, Ministry of Education
National Clinical Research Center for Otolaryngologic Diseases
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School
State Key Laboratory of Hearing and Balance Science
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China
National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
Key Laboratory of Hearing Science, Ministry of Education, Beijing, China
raw_author_name: Pu Dai
raw_affiliation_strings: Beijing Key Laboratory of Hearing Impairment Prevention and Treatment
Key Laboratory of Hearing Science, Ministry of Education
National Clinical Research Center for Otolaryngologic Diseases
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School
State Key Laboratory of Hearing and Balance Science
Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China
Key Laboratory of Hearing Science, Ministry of Education, Beijing, China
National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
raw_author_name: Xue Gao
raw_affiliation_strings: Department of Otolaryngology, PLA Rocket Force Characteristic Medical Center
Department of Otolaryngology, PLA Rocket Force Characteristic Medical Center, Beijing, China
raw_author_name: Yi-hui Zou
raw_affiliation_strings: National Clinical Research Center for Otolaryngologic Diseases
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School
State Key Laboratory of Hearing and Balance Science
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China
National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
State Key Laboratory of Hearing and Balance Science, Beijing, China
raw_author_name: Yong-yi Yuan
raw_affiliation_strings: Beijing Key Laboratory of Hearing Impairment Prevention and Treatment
Key Laboratory of Hearing Science, Ministry of Education
National Clinical Research Center for Otolaryngologic Diseases
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School
State Key Laboratory of Hearing and Balance Science
Key Laboratory of Hearing Science, Ministry of Education, Beijing, China
National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China
Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China