Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma
Year: 2025
Type: article
Language: en
Topic: Multiple Myeloma Research and Treatments
Authors and affiliations:
raw_author_name: Denis J. Ohlstrom
raw_affiliation_strings: 2Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia
Georgia Institute of Technology 1 Coulter Department of Biomedical Engineering, , Atlanta, Georgia
Georgia Institute of Technology, Atlanta, GA, United States
raw_author_name: William C. Pilcher
raw_affiliation_strings: Georgia Institute of Technology 1 Coulter Department of Biomedical Engineering, , Atlanta, Georgia
Emory University, Atlanta, Ga, United States
raw_author_name: Marina E. Michaud
raw_affiliation_strings: 2Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia
Emory University, Atlanta, GA, United States
raw_author_name: Chaitanya Acharya
raw_affiliation_strings: MMRF 3 , Norwalk, Connecticut
Multiple Myeloma Research Foundation, United States
raw_author_name: Sarthak Satpathy
raw_affiliation_strings: 4Department of Biomedical Informatics, Emory School of Medicine, Atlanta, Georgia
Emory University, Atlanta, GA, United States
raw_author_name: Edgar Gonzalez-Kozlova
raw_affiliation_strings: Icahn School of Medicine at Mount Sinai 5 Department of Immunology and Immunotherapy, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai 6 Department of Genetics and Genomic Sciences, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai, New York, NY, United States
raw_author_name: Reyka G. Jayasinghe
raw_affiliation_strings: Washington University in St. Louis 7 Department of Medicine, , St. Louis, Missouri
Washington University in St. Louis, Saint Louis, MO, United States
raw_author_name: Katherine Ferguson
raw_affiliation_strings: Georgia Institute of Technology 1 Coulter Department of Biomedical Engineering, , Atlanta, Georgia
Georgia Institute of Technology, United States
raw_author_name: Hope L. Mumme
raw_affiliation_strings: 4Department of Biomedical Informatics, Emory School of Medicine, Atlanta, Georgia
Emory University, Decatur, GA, United States
raw_author_name: Shivani Nanda
raw_affiliation_strings: 10Broad Institute of MIT and Harvard, Cambridge, Massachusetts
9Harvard Medical School, Boston, Massachusetts
Beth Israel Deaconess Medical Center 8 , Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, MA, United States
raw_author_name: Yizhe Song
raw_affiliation_strings: Washington University in St. Louis 7 Department of Medicine, , St. Louis, Missouri
Washington University in St. Louis, St. Louis, MO, United States
raw_author_name: Sowmitri Mantrala
raw_affiliation_strings: 4Department of Biomedical Informatics, Emory School of Medicine, Atlanta, Georgia
Emory University, United States
raw_author_name: Dimitra Karagkouni
raw_affiliation_strings: 10Broad Institute of MIT and Harvard, Cambridge, Massachusetts
9Harvard Medical School, Boston, Massachusetts
Beth Israel Deaconess Medical Center 8 , Boston, Massachusetts
Beth Israel Deaconess Medical Center, United States
raw_author_name: Jessica Schulman
raw_affiliation_strings: MMRF 3 , Norwalk, Connecticut
Multiple Myeloma Research Foundation, United States
raw_author_name: Nick Pabustan
raw_affiliation_strings: MMRF 3 , Norwalk, Connecticut
Multiple Myeloma Research Foundation, United States
raw_author_name: Junia Vieira Dos Santos
raw_affiliation_strings: Icahn School of Medicine at Mount Sinai 5 Department of Immunology and Immunotherapy, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai 6 Department of Genetics and Genomic Sciences, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai, United States
raw_author_name: Daniel W. Sherbenou
raw_affiliation_strings: University of Colorado Anschutz Medical Campus 11 , Aurora, Colorado
University of Colorado Anschutz Medical Campus, Aurora, CO, United States
raw_author_name: Jonathan J. Keats
raw_affiliation_strings: Translational Genomics Research Institute 12 Integrated Cancer Genomics Division, , Phoenix, Arizona
Translational Genomics Research Institute, Phoenix, AZ, United States
raw_author_name: Alexander M. Gout
raw_affiliation_strings: MMRF 3 , Norwalk, Connecticut
Multiple Myeloma Research Foundation, United States
raw_author_name: Steven Foltz
raw_affiliation_strings: MMRF 3 , Norwalk, Connecticut
Multiple Myeloma Research Foundation, Norwalk, CT, United States
raw_author_name: Alessandro Lagana
raw_affiliation_strings: Icahn School of Medicine at Mount Sinai 5 Department of Immunology and Immunotherapy, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai 6 Department of Genetics and Genomic Sciences, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai, New York, United States
raw_author_name: Taxiarchis Kourelis
raw_affiliation_strings: Mayo Clinic 13 , Rochester, Minnesota
Mayo Clinic, Rochester, MN, United States
raw_author_name: Ravi Vij
raw_affiliation_strings: 15Bone Marrow Transplantation & Leukemia Section, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri
Washington University in St. Louis 14 Siteman Cancer Center, , St. Louis, Missouri
Washington University in St. Louis, Saint Louis, MO, United States
raw_author_name: Madhav V. Dhodapkar
raw_affiliation_strings: 16Department of Hematology Oncology, Emory School of Medicine, Atlanta, Georgia
17Winship Cancer Institute, Emory School of Medicine, Atlanta, Georgia
Fred Hutchinson Cancer Center, Seattle, CA, United States
raw_author_name: David Avigan
raw_affiliation_strings: 9Harvard Medical School, Boston, Massachusetts
Beth Israel Deaconess Medical Center 18 Cancer Center & Cancer Research Institute, , Boston, Massachusetts
Beth Israel Deaconess Medical Center 8 , Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, MA, United States
raw_author_name: Hearn Jay Cho
raw_affiliation_strings: Icahn School of Medicine at Mount Sinai 5 Department of Immunology and Immunotherapy, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai 6 Department of Genetics and Genomic Sciences, Tisch Cancer Institute, , New York, New York
MMRF 3 , Norwalk, Connecticut
Icahn School of Medicine at Mount Sinai, New York, New York, United States
raw_author_name: Linda B. Baughn
raw_affiliation_strings: Mayo Clinic 13 , Rochester, Minnesota
Mayo Clinic, Rochester, MN, United States
raw_author_name: Ajay K. Nooka
raw_affiliation_strings: 16Department of Hematology Oncology, Emory School of Medicine, Atlanta, Georgia
Emory University, Atlanta, GA, United States
raw_author_name: Sagar Lonial
raw_affiliation_strings: 19Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, Georgia
2Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia
Winship Cancer Institute, Atlanta, GA, United States
raw_author_name: Shaji Kumar
raw_affiliation_strings: Mayo Clinic 13 , Rochester, Minnesota
Mayo Clinic, Rochester, MN, United States
raw_author_name: Mehmet K. Samur
raw_affiliation_strings: 20Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
21Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, MA, United States
raw_author_name: Ioannis S. Vlachos
raw_affiliation_strings: 10Broad Institute of MIT and Harvard, Cambridge, Massachusetts
22Spatial Technologies Unit, Harvard Medical School Initiative for RNA Medicine, Boston, Massachusetts
9Harvard Medical School, Boston, Massachusetts
Beth Israel Deaconess Medical Center 18 Cancer Center & Cancer Research Institute, , Boston, Massachusetts
Beth Israel Deaconess Medical Center 8 , Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, MA, United States
raw_author_name: Li Ding
raw_affiliation_strings: 15Bone Marrow Transplantation & Leukemia Section, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri
Washington University in St. Louis 7 Department of Medicine, , St. Louis, Missouri
Washington University in St. Louis, St Louis, MO, United States
raw_author_name: Sacha Gnjatic
raw_affiliation_strings: Icahn School of Medicine at Mount Sinai 23 Human Immune Monitoring Center, Department of Immunology and Immunotherapy, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai 5 Department of Immunology and Immunotherapy, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai 6 Department of Genetics and Genomic Sciences, Tisch Cancer Institute, , New York, New York
Icahn School of Medicine at Mount Sinai, New York, NY, United States
raw_author_name: George Mulligan
raw_affiliation_strings: MMRF 3 , Norwalk, Connecticut
Multiple Myeloma Research Foundation, Norwalk, CT, United States
raw_author_name: Manoj K. Bhasin
raw_affiliation_strings: 2Department of Pediatrics, Emory School of Medicine, Atlanta, Georgia
4Department of Biomedical Informatics, Emory School of Medicine, Atlanta, Georgia
Georgia Institute of Technology 1 Coulter Department of Biomedical Engineering, , Atlanta, Georgia
Emory University, Atlanta, GA, United States