Rare Variants in Pulmonary Arterial Hypertension-Related Genes Associate With a Distinct Vasculopathy Phenotype and Worse Outcomes in Patients With Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension
Year: 2025
Type: article
Language: en
Topic: Pulmonary Hypertension Research and Treatments
Authors and affiliations:
raw_author_name: Junyan Qian
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Xinzhuang Yang
raw_affiliation_strings: Center for Bioinformatics, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Beijing
Center for Bioinformatics, National Infrastructures for Translational Medicine, Institute of Clinical Medicine & Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
raw_author_name: Qian Wang
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Jiuliang Zhao
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Leyao Ma
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Yufang Ding
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Qizhi Yuan
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Mucong Li
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing. Electronic address: mengtao.li@cstar.cn
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Weida Liu
raw_affiliation_strings: State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing
State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China
raw_author_name: Yongtai Liu
raw_affiliation_strings: Department of Cardiology, Peking Union Medical College Hospital, Beijing
Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
raw_author_name: Zhuang Tian
raw_affiliation_strings: Department of Cardiology, Peking Union Medical College Hospital, Beijing
Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
raw_author_name: Yanhong Wang
raw_affiliation_strings: Department of Epidemiology and Bio-Statistics, Beijing
Department of Epidemiology and Bio-Statistics, Institute of Basic Medical Sciences, China Academy of Medical Sciences & Peking Union Medical College, Beijing, China
raw_author_name: Weixian Yang
raw_affiliation_strings: Institute of Basic Medical Sciences, the Department of Cardiology, Beijing; Key Laboratory of Pulmonary Vascular Medicine, Beijing
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Key Laboratory of Pulmonary Vascular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
raw_author_name: Xiaofeng Zeng
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
raw_author_name: Xiaojian Wang
raw_affiliation_strings: Key Laboratory of Pulmonary Vascular Medicine, Beijing; State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, Beijing; National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Fuwai Central-China Hospital, Central-China Branch of National Center for Cardiovascular Diseases, Zhengzhou, China
Key Laboratory of Pulmonary Vascular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Fuwai Central-China Hospital, Central-China Branch of National Center for Cardiovascular Diseases, Zhengzhou, China. Electronic address: mengtao.li@cstar.cn
raw_author_name: Mengtao Li
raw_affiliation_strings: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing; National Center for Cardiovascular Diseases, the National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing. Electronic address: mengtao.li@cstar.cn
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. Electronic address: wang_xiaojian@vip.163.com