Impact of YAQ001 on the gut microbiome, permeability and markers of systemic inflammation in patients with cirrhosis
Year: 2025
Type: article
Topic: Liver Disease and Transplantation
Authors and affiliations:
raw_author_name: Jinxia Liu
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.  Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, China.;
raw_author_name: Fernando Garcia-Guevara
raw_affiliation_strings: Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, Kings College London, SE1 9RT, UK.;
raw_author_name: Jane Macnaughtan
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Yi Jin
raw_affiliation_strings: Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, Kings College London, SE1 9RT, UK.;
raw_author_name: Ainhoa Ferret
raw_affiliation_strings: Institute for Bioengineering of Catalonia (IBEC);
raw_author_name: Frederick Clasen
raw_affiliation_strings: Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, Kings College London, SE1 9RT, UK.;
raw_author_name: Nicholas Yuen
raw_affiliation_strings: Department of Renal Medicine, Division of Medicine, University College London, London WC1E 6BT UK;
raw_author_name: Ramón Garcia Maset
raw_affiliation_strings: Department of Engineering Science, University of Oxford;
raw_author_name: Javier Ramón-Azcón
raw_affiliation_strings: Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain;
raw_author_name: Annarein JC Kerbert
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Theo Portlock
raw_affiliation_strings: Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, Kings College London, SE1 9RT, UK.;
raw_author_name: Javier Martinez
raw_affiliation_strings: Hospital Ramon y Cajal, IRYCIS, CIBEREHD, Universidad de Alcala, Madrid;
raw_author_name: Abeba Habtesion
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Alexandra Phillips
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Francesco De Chiara
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Ganesh Ingavle
raw_affiliation_strings: Centre for Regenerative Medicine and Devices, School of Applied Sciences, University of Brighton, Brighton, East Sussex, BN2 4GJ, UK Advanced Cell Therapy manufacturing (GMP) Unit, Clinical Research Facility, NIHR Biomedical Research Centre;
raw_author_name: Tom Baldwin
raw_affiliation_strings: Genetics and Genomic Medicine Department, Institute of Child Health, University College London;
raw_author_name: Cesar Jimenez
raw_affiliation_strings: Liver Unit, Hospital Vall d Hebron, Universitat Autonoma, CIBERehd, Barcelona, Spain;
raw_author_name: Giacomo Zaccherini
raw_affiliation_strings: Department of Medical and Surgical Sciences, University of Bologna, Italy  Unit of Semeiotics, Liver and Alcohol-related Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy;
raw_author_name: Katherine Husi
raw_affiliation_strings: Gastroenterology, University Hospital Bern, CH;
raw_author_name: Miguel Rodriguez-Gandia
raw_affiliation_strings: Hospital Ramon y Cajal, IRYCIS, CIBEREHD, Universidad de Alcala, Madrid, Spain;
raw_author_name: Paul Cordero-Sanchez
raw_affiliation_strings: Symbiosis Centre for Stem Cell Research (SCSCR), Symbiosis School of Biological Sciences (SSBS), Symbiosis International (Deemed University), Pune 412115, India.;
raw_author_name: Junpei Soeda
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Jude A Oben
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Karen Church
raw_affiliation_strings: Yaqrit Discovery Limited. The Elms Courtyard, Bromesberrow, Ledbury, United Kingdom, HR8 1RZ;
raw_author_name: Jia V. Li
raw_affiliation_strings: Section of Nutrition, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Hammersmith Hospital, Du Cane Road, London, W12 0NN.;
raw_author_name: Aarti Jalan
raw_affiliation_strings: Kings College Hospital, 125 Coldharbour Lane, London SE5 9NU, UK London;
raw_author_name: Adria Juanola
raw_affiliation_strings: Liver Unit, Hospital Clinic of Barcelona, IDIBAPS, Faculty of Medicine and Health sciences, University of Barcelona. CIBEReHD;
raw_author_name: Elsa Sola
raw_affiliation_strings: Liver Unit, Hospital Clinic of Barcelona, IDIBAPS, Faculty of Medicine and Health sciences, University of Barcelona. CIBEReHD;
raw_author_name: Simon Eaton
raw_affiliation_strings: Institute of Child Health, University College London;
raw_author_name: Carrie Morgan
raw_affiliation_strings: Rarity Discovery Limited. The Elms Courtyard, Bromesberrow, Ledbury, United Kingdom, HR8 1RZ;
raw_author_name: Thomas Avery
raw_affiliation_strings: Yaqrit Discovery Limited. The Elms Courtyard, Bromesberrow, Ledbury, United Kingdom, HR8 1RZ;
raw_author_name: Michal Kowalski
raw_affiliation_strings: Yaqrit Discovery Limited. The Elms Courtyard, Bromesberrow, Ledbury, United Kingdom, HR8 1RZ;
raw_author_name: Daniel Green
raw_affiliation_strings: Imperial College, Department of Bioengineering, London SW7 2AZ.;
raw_author_name: Amir Gander
raw_affiliation_strings: Tissue Access for Patient Benefit: ROYAL FREE HOSPITAL;
raw_author_name: Lindsey Ann Edwards
raw_affiliation_strings: Centre for Host Microbiome Interactions, Kings College London, Faculty of Dentistry, Oral & Craniofacial Sciences, Guys Tower, Guys Hospital, Great Maze Pond, London, SE1 1UL, UK.;
raw_author_name: I. Jane Cox
raw_affiliation_strings: Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, Kings College London, Foundation for Liver Research and Kings College Hospital, London, UK;
raw_author_name: Helena Cortez-Pinto
raw_affiliation_strings: Clinica Universitaria de Gastrenterologia, Faculdade de Medicina, Universidade de Lisboa, Portugal;
raw_author_name: Reiner Wiest
raw_affiliation_strings: Gastroenterology, University Hospital Bern, CH;
raw_author_name: Francois Durand
raw_affiliation_strings: Hepatology and Liver Intensive Care, Hospital Beaujon, Clichy, University paris Cite, Paris, France;
raw_author_name: Paolo Caraceni
raw_affiliation_strings: Department of Medical and Surgical Sciences, University of Bologna, Italy  Unit of Semeiotics, Liver and Alcohol.related Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy;
raw_author_name: Roberto Elosua
raw_affiliation_strings: C/ de Joan Guell, 184, Les Corts, 08028 Barcelona, Spain;
raw_author_name: Joan Vila
raw_affiliation_strings: C/ de Joan Guell, 184, Les Corts, 08028 Barcelona, Spain;
raw_author_name: Marco Pavesi
raw_affiliation_strings: BCCC-Fundacio Mon Clinic, Barcelona.;
raw_author_name: Vicente Arroyo
raw_affiliation_strings: European Foundation for the Study of Chronic Liver Failure (EF Clif), Barcelona;
raw_author_name: Nathan Davies
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Rajeshwar P Mookerjee
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Victor Vargas
raw_affiliation_strings: Liver Unit, Hospital Vall d Hebron, Universitat Autonoma, CIBERehd, Barcelona, Spain;
raw_author_name: Susan Sandeman
raw_affiliation_strings: Centre for Regenerative Medicine and Devices, School of Applied Sciences, University of Brighton, Brighton, East Sussex, BN2 4GJ, UK.;
raw_author_name: Gautam Mehta
raw_affiliation_strings: University College London;
raw_author_name: Julian R. Marchesi
raw_affiliation_strings: Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, South Wharf Road, London, W2 1NY;
raw_author_name: Agustin Albillos
raw_affiliation_strings: Department of Gastroenterology and Hepatology, Hospital Universitario Ramon y Cajal;
raw_author_name: Jennifer L. Rohn
raw_affiliation_strings: Department of Renal Medicine, Division of Medicine
raw_author_name: Fausto Andreola
raw_affiliation_strings: Liver Failure Group, UCL Institute for Liver and Digestive Health, Upper third floor, Royal Free Campus, Rowland Hill Street, Hampstead, London, NW3 2PF.;
raw_author_name: Saeed Shoaie
raw_affiliation_strings: Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, Kings College London, SE1 9RT, UK.;
raw_author_name: Rajiv Jalan
raw_affiliation_strings: University College London;