Integrated strategies of network pharmacology, transcriptomics, and computational and experimental validation reveal the anti-osteosarcoma effects of juglone via the ROS/PI3K/AKT pathway
Year: 2025
Type: article
Language: en
Topic: Bioactive Compounds and Antitumor Agents
Authors and affiliations:
raw_author_name: Haichuan Miao
raw_affiliation_strings: Dalian Medical University, Dalian, 116044, China
Dalian Medical University, Dalian 116044, China
raw_author_name: Baolong Liu
raw_affiliation_strings: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, 77 Puhe Road, Shenbei New District, 110122, Shenyang, China
Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, 77 Puhe Road, Shenbei New District, 110122 Shenyang, China
raw_author_name: Xinfang Pan
raw_affiliation_strings: Department of Laboratory Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116044, China
Department of Laboratory Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China
raw_author_name: Zhihua Cheng
raw_affiliation_strings: Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China
Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China
raw_author_name: Qizhen Xue
raw_affiliation_strings: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, 77 Puhe Road, Shenbei New District, 110122, Shenyang, China
Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, 77 Puhe Road, Shenbei New District, 110122 Shenyang, China
raw_author_name: Dongda Han
raw_affiliation_strings: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, 77 Puhe Road, Shenbei New District, 110122, Shenyang, China
Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, 77 Puhe Road, Shenbei New District, 110122 Shenyang, China
raw_author_name: Zhongshen Yu
raw_affiliation_strings: Department of Sports Medicine and Joint Surgery, The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang, 110016, China. Electronic address: yzs5269@126.com
Department of Sports Medicine and Joint Surgery, The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang 110016, China. Electronic address: yzs5269@126.com
raw_author_name: Liwei Zhang
raw_affiliation_strings: Orthopedic Department, Taizhou Hospital of Zhejiang Province, School of Medicine, Zhejiang University, Taizhou, 317000, China. Electronic address: medzlw@sina.com
raw_author_name: Xizhuang Bai
raw_affiliation_strings: Dalian Medical University, Dalian, 116044, China; Department of Sports Medicine and Joint Surgery, The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang, 110016, China. Electronic address: educmu0922@163.com
Dalian Medical University, Dalian 116044, China; Department of Sports Medicine and Joint Surgery, The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang 110016, China. Electronic address: educmu0922@163.com