Genome-wide association study of REM-sleep behaviour disorder identifies new risk loci
Year: 2025
Type: article
Topic: Parkinson's Disease Mechanisms and Treatments
Authors and affiliations:
raw_author_name: Emma N. Somerville
raw_affiliation_strings: Department of Human Genetics, McGill University, Montréal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Lang Liu
raw_affiliation_strings: Department of Human Genetics, McGill University, Montréal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Lynne Krohn
raw_affiliation_strings: Department of Human Genetics, McGill University, Montréal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Farnaz Asayesh
raw_affiliation_strings: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Jamil Ahmad
raw_affiliation_strings: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Dan Spiegelman
raw_affiliation_strings: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Meron Teferra
raw_author_name: Manuela Tan
raw_affiliation_strings: Department of Neurology, Oslo University Hospital, Oslo, Norway
raw_author_name: Sheena Waters
raw_affiliation_strings: Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
raw_author_name: Cristina Simonet
raw_affiliation_strings: Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
raw_author_name: Laura Pérez-Carbonell
raw_affiliation_strings: Sleep Disorders Centre, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
raw_author_name: Anette Schrag
raw_affiliation_strings: University College London Institute of Neurology, University College London, London, UK
raw_author_name: Pauline Dodet
raw_affiliation_strings: Sleep Disorders Unit, Sorbonne University, Institut du Cerveau–-Paris Brain Institute–-ICM, Inserm, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France
raw_author_name: Isabelle Arnulf
raw_affiliation_strings: Sleep Disorders Unit, Sorbonne University, Institut du Cerveau–-Paris Brain Institute–-ICM, Inserm, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France
raw_author_name: Michele T.M. Hu
raw_affiliation_strings: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
raw_author_name: Yo-El Ju
raw_affiliation_strings: Washington University Multidisciplinary Sleep Center, St. Louis, Missouri, USA
raw_author_name: Jacques Y. Montplaisir
raw_affiliation_strings: Centre d’Études Avancées en Médecine du Sommeil, CIUSSS-NÎM – Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada
Department of Psychiatry, Université de Montréal, Montréal, QC, Canada
raw_author_name: Jean-François Gagnon
raw_affiliation_strings: Centre d’Études Avancées en Médecine du Sommeil, CIUSSS-NÎM – Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada
Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada
raw_author_name: Alex Desautels
raw_affiliation_strings: Centre d’Études Avancées en Médecine du Sommeil, CIUSSS-NÎM – Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada
Department of Neurosciences, Université de Montréal, Montréal, QC, Canada
raw_author_name: Yves Dauvilliers
raw_affiliation_strings: National Reference Centre for Orphan Diseases, Narcolepsy-Rare hypersomnias, Sleep Unit, Department of Neurology, CHU Montpellier, Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France
raw_author_name: Merve Aktan-Süzgün
raw_affiliation_strings: Department of Psychiatry, Université de Montréal, Montréal, QC, Canada
raw_author_name: Abubaker Ibrahim
raw_affiliation_strings: Department of Neurology, Center for Sleep Medicine, Medical University of Innsbruck, Innsbruck, Austria
raw_author_name: Ambra Stefani
raw_affiliation_strings: Department of Neurology, Center for Sleep Medicine, Medical University of Innsbruck, Innsbruck, Austria
raw_author_name: Birgit Hogl
raw_affiliation_strings: Department of Neurology, Center for Sleep Medicine, Medical University of Innsbruck, Innsbruck, Austria
raw_author_name: Carles Gaig
raw_affiliation_strings: Sleep Unit, Neurology Service, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Spain
raw_author_name: Angelica Montini
raw_affiliation_strings: Sleep Unit, Neurology Service, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Spain
raw_author_name: Gerard Maya
raw_affiliation_strings: Sleep Unit, Neurology Service, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Spain
raw_author_name: Alex Iranzo
raw_affiliation_strings: Sleep Unit, Neurology Service, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Spain
raw_author_name: Monica Serradell
raw_affiliation_strings: Sleep Unit, Neurology Service, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Spain
raw_author_name: Gian Luigi Gigli
raw_affiliation_strings: Department of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy
Department of Medicine (DMED), University of Udine, Udine, Italy
raw_author_name: Mariarosaria Valente
raw_affiliation_strings: Department of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy
Department of Medicine (DMED), University of Udine, Udine, Italy
raw_author_name: Francesco Janes
raw_affiliation_strings: Department of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy
Department of Medicine (DMED), University of Udine, Udine, Italy
raw_author_name: Andrea Bernardini
raw_affiliation_strings: Department of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy
Department of Medicine (DMED), University of Udine, Udine, Italy
raw_author_name: Karel Sonka
raw_affiliation_strings: Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
raw_author_name: David Kemlink
raw_affiliation_strings: Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
raw_author_name: Petr Dusek
raw_affiliation_strings: Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
raw_author_name: Gültekin Tamgüney
raw_affiliation_strings: Heinrich-Heine-Universität Düsseldorf, Mathematisch-Naturwissenschaftliche Fakultät, Institut für Physikalische Biologie, Düsseldorf, Germany
Institute of Biological Information Processing, Forschungszentrum Jülich, Jülich, Germany
raw_author_name: Michael Sommerauer
raw_affiliation_strings: Center for Neurology, Department of Parkinson, Sleep, and Movement Disorders, University Hospital of Bonn, Bonn, Germany
Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
raw_author_name: Michela Figorilli
raw_affiliation_strings: Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy
raw_author_name: Monica Puligheddu
raw_affiliation_strings: Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy
raw_author_name: Brit Mollenhauer
raw_affiliation_strings: Department of Neurology, University Medical Centre Göttingen, Göttingen, Germany
Paracelsus-Elena-Klinik, Kassel, Germany
raw_author_name: Claudia Trenkwalder
raw_affiliation_strings: Department of Neurology, University Medical Centre Göttingen, Göttingen, Germany
Paracelsus-Elena-Klinik, Kassel, Germany
raw_author_name: Friederike Sixel-Doring
raw_affiliation_strings: Department of Neurology, Philipps University, Marburg, Germany
Paracelsus-Elena-Klinik, Kassel, Germany
raw_author_name: Giuseppe Plazzi
raw_affiliation_strings: Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia, Modena, Italy
IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy
raw_author_name: Francesco Biscarini
raw_affiliation_strings: Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy
IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy
raw_author_name: Elena Antelmi
raw_affiliation_strings: Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy, Neurology Unit, University of Verona, Verona, Italy
raw_author_name: Valerie Cochen De Cock
raw_affiliation_strings: EuroMov, University of Montpellier, Montpellier, France
Sleep and Neurology Unit, Beau Soleil Clinic, Montpellier, France
raw_author_name: Wolfgang Oertel
raw_affiliation_strings: Department of Neurology, Philipps-University, Marburg, Germany
raw_author_name: Annette Janzen
raw_affiliation_strings: Department of Neurology, Philipps-University, Marburg, Germany
raw_author_name: Michele Terzaghi
raw_affiliation_strings: Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
raw_author_name: Giuseppe Fiamingo
raw_affiliation_strings: Center for Advanced Research in Sleep Medicine, Research center of the CIUSS du Nord-de-l’Ile-de-Montréal Montréal, Montréal, Québec, Canada
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
raw_author_name: Anna Heidbreder
raw_affiliation_strings: Institute of Sleep Medicine and Neuromuscular Disorders, University of Münster, Münster, Germany
raw_author_name: Christelle Charley Monaca
raw_affiliation_strings: University Lille North of France, Department of Clinical Neurophysiology and Sleep Center, CHU Lille, Lille, France
raw_author_name: Luigi Ferini-Strambi
raw_affiliation_strings: Department of Neurological Sciences, Università Vita-Salute San Raffaele, Milan, Italy
raw_author_name: Kristina Kulsarova
raw_affiliation_strings: Department of Clinical Neurosciences, Scientific Park MEDIPARK, P.J. Safarik University, Kosice, Slovak Republic
Department of Neurology, Faculty of Medicine, P. J. Safarik University, Kosice, Slovakia
Department of Neurology, University Hospital of L. Pasteur, Kosice, Slovakia
raw_author_name: Miriam Ostrozovicova
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Department of Neurology, Faculty of Medicine, P. J. Safarik University, Kosice, Slovakia
Department of Neurology, University Hospital of L. Pasteur, Kosice, Slovakia
Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, United Kingdom
raw_author_name: Matej Skorvanek
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Department of Neurology, University Hospital of L. Pasteur, Kosice, Slovakia
raw_author_name: Femke Dijkstra
raw_affiliation_strings: Department of Neurology, Antwerp University Hospital, Edegem, Belgium
Department of Neurology, St. Dimpna Regional Hospital, Geel, Belgium
Laboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium
raw_author_name: Mineke Viaene
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Laboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium
raw_author_name: Jitka Bušková
raw_affiliation_strings: Department of Sleep Medicine, National Institute of Mental Health, Klecany, Czech Republic
Third Faculty of Medicine, Charles University, Prague, Czech Republic
raw_author_name: Beatriz Abril
raw_affiliation_strings: Sleep disorder Unit, Carémeau Hospital, University Hospital of Nîmes, Nîmes, France
raw_author_name: Beatrice Orso
raw_affiliation_strings: Department of Neuroscience (DINOGMI), University of Genoa, Italy
raw_author_name: Pietro Mattioli
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Neurophysiology unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
raw_author_name: Dario Arnaldi
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Neurophysiology unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
raw_author_name: Bradley F. Boeve
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raw_author_name: Guy A. Rouleau
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Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Ronald B. Postuma
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The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Jaeyoon Chung
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raw_author_name: Daria Prilutsky
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raw_author_name: Kajsa Atterling Brolin
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Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
raw_author_name: Alastair J. Noyce
raw_affiliation_strings: Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
raw_author_name: Owen A. Ross
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Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
raw_author_name: Cornelis Blauwendraat
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Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, US
raw_author_name: Ziv Gan-Or
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Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: the Global Parkinson’s Genetics Program (GP2)