A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates
Year: 2025
Type: article
Language: en
Topic: Pediatric Hepatobiliary Diseases and Treatments
Authors and affiliations:
raw_author_name: Yanhui Xu
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Xixi Chen
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China; Liuzhou Hospital, Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi 545616, China
raw_author_name: Rongli Fang
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China; Liuzhou Hospital, Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi 545616, China
raw_author_name: Xiaolei Wang
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Yanfang Zhang
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China; Liuzhou Hospital, Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi 545616, China; Chongqing International Institute for Immunology, Chongqing 404100, China; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China. Electronic address: yuxia.zhang@gwcmc.org
raw_author_name: Huifang Ren
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Yunnan Xiao
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Yu Ning
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Xiaotian Li
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Chengwei Chai
raw_affiliation_strings: Department of Pediatric General Surgery, Guangdong Women and Children Hospital, Guangzhou, Guangdong 511442, China
raw_author_name: Wen Lei
raw_affiliation_strings: Liuzhou Hospital, Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi 545616, China
raw_author_name: Kanghua Zhong
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Jiankun Liang
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Qifeng Liang
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Yuanyuan Luo
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Qiuming He
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Zefeng Lin
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Zhenhua Luo
raw_affiliation_strings: Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China
raw_author_name: Ming Liu
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Weiwei Liang
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Tingting Chen
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Xiaoqiong Gu
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Jinbao Liu
raw_affiliation_strings: Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Affiliated Cancer Hospital, Institute of Guangzhou Medical University, Guangzhou 510623, China
raw_author_name: Junqiang Lv
raw_affiliation_strings: Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
raw_author_name: Zhi Yao
raw_affiliation_strings: Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
raw_author_name: Hai-Biao Gong
raw_affiliation_strings: State Key Laboratory of Bioactive Molecules and Drugability Assessment, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China
raw_author_name: Wan-Yang Sun
raw_affiliation_strings: State Key Laboratory of Bioactive Molecules and Drugability Assessment, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China
raw_author_name: Rong-Rong He
raw_affiliation_strings: State Key Laboratory of Bioactive Molecules and Drugability Assessment, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China
raw_author_name: Andrew M. Lew
raw_affiliation_strings: Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, Department of Microbiology & Immunology, University of Melbourne, Parkville, VIC 3052, Australia
raw_author_name: Huimin Xia
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
raw_author_name: Yuzhang Wu
raw_affiliation_strings: Chongqing International Institute for Immunology, Chongqing 404100, China
raw_author_name: Wenhao Zhou
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China. Electronic address: zhouwenhao@fudan.edu.cn
raw_author_name: Zhe Wen
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China. Electronic address: wenzhe2005@163.com
raw_author_name: Zhanghua Chen
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China; Liuzhou Hospital, Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi 545616, China. Electronic address: zhanghua.chen@gwcmc.org
raw_author_name: Yuxia Zhang
raw_affiliation_strings: Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Clinical Research Center for Pediatric Infection and Immunity, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China; Liuzhou Hospital, Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi 545616, China; Chongqing International Institute for Immunology, Chongqing 404100, China; The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China. Electronic address: yuxia.zhang@gwcmc.org