Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study
Year: 2025
Type: article
Language: en
Topic: Intensive Care Unit Cognitive Disorders
Authors and affiliations:
raw_author_name: Felix Klawitter
raw_affiliation_strings: Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Johanna Hackenberg
raw_affiliation_strings: Department of Paediatrics, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Lena Danckert
raw_affiliation_strings: Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Astrid Bertsche
raw_affiliation_strings: Department of Neuropaediatrics, University Medical Centre Greifswald, Greifswald, Germany
Department of Paediatrics, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Axel Petzold
raw_affiliation_strings: The National Hospital for Neurology and Neurosurgery, University College London & Moorfields Eye Hospital, London, UK
raw_author_name: Heidi A.B. Smith
raw_affiliation_strings: Department of Anaesthesiology, Vanderbilt University Medical Centre, Nashville, USA
Department of Paediatrics, Children's Hospital, Vanderbilt University Medical Centre, Monroe Carell Jr, Nashville, USA
raw_author_name: Eugene Wesley Ely
raw_affiliation_strings: Critical Illness, Brain Dysfunction, Survivorship (CIBS) Centre, Department of Medicine, Vanderbilt University Medical Centre, Nashville, USA
Tennessee Valley Veteran's Affairs Geriatric Research Education Clinical Centre (GRECC), Nashville, USA
raw_author_name: Christian Spang
raw_affiliation_strings: Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
Department of Paediatrics, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Rika Bajorat
raw_affiliation_strings: Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Dagmar-Christiane Fischer
raw_affiliation_strings: Department of Paediatrics, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Gerd Klinkmann
raw_affiliation_strings: Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
Department of Extracorporeal Therapy Systems, Fraunhofer Institute for Cell Therapy and Immunology, Rostock, Germany
International Renal Research Institute of Vicenza, Vicenza, Veneto, Italy
raw_author_name: Anne Körmann-Günther
raw_affiliation_strings: Department of Paediatrics, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany
raw_author_name: Robert Fleischmann
raw_affiliation_strings: Department of Neurology, University Medicine Greifswald, Greifswald, Germany
raw_author_name: Amanda Heslegrave
raw_affiliation_strings: Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK
UK Dementia Research Institute at University College London, Fluid Biomarker Laboratory, London, WC1E 6BT, UK
raw_author_name: Henrik Zetterberg
raw_affiliation_strings: Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China
UK Dementia Research Institute at University College London, Fluid Biomarker Laboratory, London, WC1E 6BT, UK
Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin- Madison, Madison, WI, 53792, USA
raw_author_name: Hessel Peters-Sengers
raw_affiliation_strings: Center for Infection and Molecular Medicine, Location AMC, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
Department of Epidemiology and Data Science, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
raw_author_name: Johannes Ehler
raw_affiliation_strings: Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Am Klinikum 1, 07749, Jena, Germany. johannes.ehler@med.uni-jena.de
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Interdisciplinary Paediatric Intensive Care Medicine, University Medical Centre Rostock, Rostock, Germany. johannes.ehler@med.uni-jena.de
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Am Klinikum 1, 07749, Jena, Germany