Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency
Year: 2025
Type: article
Language: en
Topic: Mitochondrial Function and Pathology
Authors and affiliations:
raw_author_name: Man Xu
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
raw_author_name: Yuxin Liu
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
raw_author_name: Runhua Ma
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, China
raw_author_name: Wenlu Fan
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
raw_author_name: Jingwei Duan
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
raw_author_name: Huan Deng
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
raw_author_name: Yanbin Ma
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
raw_author_name: Wanzhong Ge
raw_affiliation_strings: Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China; Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Zhejiang Provincial Clinical Research Center for Child Health, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: wanzhongge@zju.edu.cn