Epigenomic embedding of childhood adversity links to disease risk and chronic immune changes
Year: 2025
Type: article
Topic: Epigenetics and DNA Methylation
Authors and affiliations:
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raw_affiliation_strings: German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
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Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Munich, Neuherberg, Germany
raw_author_name: Aayah Nounu
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raw_author_name: A. Luise Weihs
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German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany
International Max Planck Research School for Translational Psychiatry, Munich, Germany
raw_author_name: Mira Erhart
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Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
Institute for Medical Information Processing, Biometry and Epidemiology-IBE, Medical Faculty, LMU Munich, Munich, Germany
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
raw_author_name: Lisa Maier
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Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
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Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
raw_author_name: Johanna Tuhkanen
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Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
raw_author_name: Aline D. Scherff
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German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
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Helmholtz AI, Helmholtz Zentrum München, Neuherberg, Germany
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Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
raw_author_name: Anna S. Fröhlich
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Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany
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Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany
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German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany
Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
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Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
Max Planck Institute of Psychiatry, Department Clinical Translation, Munich, Germany
LMU Munich, Department of Psychology, Munich, Germany
raw_author_name: Become Study Team
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raw_author_name: Johannes Kopf-Beck
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LMU Munich, Department of Psychology, Munich, Germany
Max Planck Institute of Psychiatry, Department Clinical Translation, Munich, Germany
German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany
raw_author_name: Optima Study Team
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Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
raw_author_name: Henry Völzke
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Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
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Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
Institute of Neurogenomics, Helmholtz Munich, Helmholtz Munich, Neuherberg, Germany
German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
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German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany
Institute of Human Genetics, Technical University of Munich, Munich, Germany
German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
Institute of Neurogenomics, Helmholtz Munich, Helmholtz Munich, Neuherberg, Germany
raw_author_name: Alexander Teumer
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German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany
Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Munich, Neuherberg, Germany
German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
raw_author_name: Juliane Winkelmann
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Institute of Neurogenomics, Helmholtz Munich, Helmholtz Munich, Neuherberg, Germany
Max Planck Institute of Psychiatry, Department Genes and Environment, Munich, Germany
raw_author_name: Holger Prokisch
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Institute of Human Genetics, Technical University of Munich, Munich, Germany
Institute of Neurogenomics, Helmholtz Munich, Helmholtz Munich, Neuherberg, Germany
German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
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Department of Machine Learning and Systems Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
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German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
Max Planck Institute of Psychiatry, Munich, Germany
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Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA
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Department of Psychiatry and Behavioral Sciences, Emory School of Medicine, Atlanta, GA, USA
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Winship Cancer Institute, Emory University, Atlanta, GA, USA
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Winship Cancer Institute, Emory University, Atlanta, GA, USA
Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, Austin, TX, USA
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Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany
Department of Pediatrics, University of California, Irvine, CA, USA
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German Center for Mental Health (DZPG), Partner Site Berlin-Potsdam, Germany
Department of Pediatrics, University of California, Irvine, CA, USA
Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany
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Department of Pediatrics, University of California, Irvine, CA, USA
German Center for Child and Adolescent Health (DZKJ), Partner Site Berlin, Germany
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Department of Pediatrics, University of California, Irvine, CA, USA
German Center for Mental Health (DZPG), Partner Site Berlin-Potsdam, Germany
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Berlin, Germany
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Department of Pediatrics, University of California, Irvine, CA, USA
German Center for Child and Adolescent Health (DZKJ), Partner Site Berlin, Germany
German Center for Mental Health (DZPG), Partner Site Berlin-Potsdam, Germany
Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia
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Icahn School of Medicine at Mount Sinai, NY, USA
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Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany
German Center for Mental Health (DZPG), Partner Site Berlin-Potsdam, Germany
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German Center for Child and Adolescent Health (DZKJ), Partner Site Munich, Munich, Germany
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German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
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German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich, Germany
German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
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German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
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German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
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