Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families
Year: 2025
Type: article
Language: en
Topic: interferon and immune responses
Authors and affiliations:
raw_author_name: Pasquale C. Putter
raw_affiliation_strings: Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre
raw_author_name: Di Guan
raw_affiliation_strings: Department of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA
Dept. of Obstetrics and Gynaecology, Columbia University Irving Medical Centre
raw_author_name: Thies Gehrmann
raw_affiliation_strings: Laboratory of Applied Microbiology and Biotechnology, Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre
raw_author_name: Daniel Kolbe
raw_affiliation_strings: Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany
Institute of Clinical Molecular Biology, Kiel University
raw_author_name: Jiping Yang
raw_affiliation_strings: Department of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA
Dept. of Obstetrics and Gynaecology, Columbia University Irving Medical Centre
raw_author_name: HyeRim Han
raw_affiliation_strings: Department of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA
Dept. of Obstetrics and Gynaecology, Columbia University Irving Medical Centre
raw_author_name: Seungsoo Kim
raw_affiliation_strings: Department of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA
Dept. of Obstetrics and Gynaecology, Columbia University Irving Medical Centre
raw_author_name: Nico Lakenberg
raw_affiliation_strings: Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre
raw_author_name: H. Eka D. Suchiman
raw_affiliation_strings: Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre
raw_author_name: Stella Trompet
raw_affiliation_strings: Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Gerontology and Geriatrics, Dept. of Internal Medicine, Leiden University Medical Centre
raw_author_name: Georg C. Liu
raw_affiliation_strings: Max Planck Institute for Biology of Ageing, Cologne, Germany
Max Planck Institute for Biology of Ageing
raw_author_name: Eugen Ballhysa
raw_affiliation_strings: Max Planck Institute for Biology of Ageing, Cologne, Germany
Max Planck Institute for Biology of Ageing
raw_author_name: Adam Antebi
raw_affiliation_strings: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
Max Planck Institute for Biology of Ageing, Cologne, Germany
Max Planck Institute for Biology of Ageing
raw_author_name: Niels M.A. van den Berg
raw_affiliation_strings: Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre
raw_author_name: Almut Nebel
raw_affiliation_strings: Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany
Institute of Clinical Molecular Biology, Kiel University
raw_author_name: Marian Beekman
raw_affiliation_strings: Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre
raw_author_name: Yousin Suh
raw_affiliation_strings: Department of Genetics and Development, Columbia University Irving Medical Centre, New York, USA
Department of Obstetrics and Gynaecology, Columbia University Irving Medical Centre, New York, USA
Dept. of Obstetrics and Gynaecology, Columbia University Irving Medical Centre
raw_author_name: P. Eline Slagboom
raw_affiliation_strings: Max Planck Institute for Biology of Ageing, Cologne, Germany
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre
raw_author_name: Joris Deelen
raw_affiliation_strings: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
Max Planck Institute for Biology of Ageing, Cologne, Germany
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
Molecular Epidemiology, Dept. of Biomedical Data Sciences, Leiden University Medical Centre