Overcoming Ligand Discovery Challenges: Developing Peptide-Based Tracers for SPSB2
Year: 2025
Type: article
Language: en
Topic: Protein Degradation and Inhibitors
Authors and affiliations:
raw_author_name: Christopher Lenz
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
raw_author_name: Lewis Elson
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
raw_author_name: Johannes Dopfer
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
raw_author_name: Frederic Farges
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
raw_author_name: Andreas Krämer
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
raw_author_name: Frank Löhr
raw_affiliation_strings: Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe-University, Max-von-Laue Str. 9, Frankfurt 60438, Germany
raw_author_name: Susanne Müller
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
raw_author_name: Stéphanie M. Guéret
raw_affiliation_strings: AstraZeneca
Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism, Biopharmaceutical R&D
raw_author_name: Herbert Waldmann
raw_affiliation_strings: Department of Chemical Biology
Faculty of Chemistry and Chemical Biology
Max-Planck-Institute of Molecular Physiology
TU Dortmund University
raw_author_name: Volker Dötsch
raw_affiliation_strings: Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe-University, Max-von-Laue Str. 9, Frankfurt 60438, Germany
raw_author_name: Krishna Saxena
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany
raw_author_name: Stefan Knapp
raw_affiliation_strings: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany
Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Johann Wolfgang Goethe-University, Max-von-Laue-Straße 15, Frankfurt am Main 60438, Germany