Overcoming EGFR resistance by monovalent and bident inhibitors targeting Cys775
Year: 2025
Type: article
Language: en
Topic: Lung Cancer Treatments and Mutations
Authors and affiliations:
raw_author_name: Zhengnian Li
raw_affiliation_strings: Department of Chemical and Systems Biology, Stanford University, California, United States
Stanford Cancer Institute, ChEM-H, Stanford University, California, United States
raw_author_name: Jie Jiang
raw_affiliation_strings: Department of Medicine, Harvard Medical School, Massachusetts, United States
Lowe Center for Thoracic Oncology and Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Yaning Wang
raw_affiliation_strings: Department of Chemical and Systems Biology, Stanford University, California, United States
Stanford Cancer Institute, ChEM-H, Stanford University, California, United States
raw_author_name: Scott B. Ficarro
raw_affiliation_strings: Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Massachusetts, United States
raw_author_name: Stephen J. Collins
raw_affiliation_strings: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Massachusetts, United States
Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Tyler S. Beyett
raw_affiliation_strings: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Massachusetts, United States
Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Ilse K. Schaeffner
raw_affiliation_strings: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Massachusetts, United States
Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Isidoro Tavares
raw_affiliation_strings: Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Massachusetts, United States
raw_author_name: Felix H. Gottlieb
raw_affiliation_strings: Department of Medicine, Harvard Medical School, Massachusetts, United States
Lowe Center for Thoracic Oncology and Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Dhiraj Suda
raw_affiliation_strings: Experimental Therapeutics Core and Robert and Renée Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Prafulla C. Gokhale
raw_affiliation_strings: Experimental Therapeutics Core and Robert and Renée Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Leah M. Black-Holmes
raw_affiliation_strings: Department of Molecular and Cellular Biology, Harvard University, Massachusetts, United States
raw_author_name: Dimitris Gazgalis
raw_affiliation_strings: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Massachusetts, United States
Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Michael J. Eck
raw_affiliation_strings: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Massachusetts, United States
Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Pasi A. Jänne
raw_affiliation_strings: Department of Medicine, Harvard Medical School, Massachusetts, United States
Lowe Center for Thoracic Oncology and Department of Medical Oncology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Jarrod A. Marto
raw_affiliation_strings: Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Massachusetts, United States
raw_author_name: Jianwei Che
raw_affiliation_strings: Department of Cancer Biology, Dana-Farber Cancer Institute, Massachusetts, United States
raw_author_name: Nathanael S. Gray
raw_affiliation_strings: Department of Chemical and Systems Biology, Stanford University, California, United States
Stanford Cancer Institute, ChEM-H, Stanford University, California, United States
raw_author_name: Tinghu Zhang
raw_affiliation_strings: Department of Chemical and Systems Biology, Stanford University, California, United States
Stanford Cancer Institute, ChEM-H, Stanford University, California, United States