Functional characterization of the 9q34.13 locus identifies <i>RAPGEF1</i> as modulating risk for melanoma and nevi via RAS activation
Year: 2025
Type: article
Topic: Melanoma and MAPK Pathways
Authors and affiliations:
raw_author_name: Rohit Thakur
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Mai Xu
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Alexandra M. Thornock
raw_affiliation_strings: Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Stem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, MA, USA
Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA
Harvard Medical School
raw_author_name: Joshuah Yon
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Samuel Anyaso-Samuel
raw_affiliation_strings: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Martin Lauss
raw_affiliation_strings: Division of Oncology, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, 22185, Sweden
Lund University Cancer Center, Lund, 22185, Sweden
Lund University
raw_author_name: Thomas Rehling
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Linh Bui-Raborn
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Hayley Sowards
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Gerard Duncan
raw_affiliation_strings: Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, USA
Leidos Biomedical Research Inc
raw_author_name: Lea Jessop
raw_affiliation_strings: Laboratory of Genomic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Timothy Myers
raw_affiliation_strings: Laboratory of Genomic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Raj Chari
raw_affiliation_strings: Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD, USA
Frederick National Laboratory for Cancer Research
raw_author_name: Erping Long
raw_affiliation_strings: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Karen Funderburk
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Jinhu Yin
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Rebecca Hennessey
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Emory Hseih
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA
National Cancer Institute
raw_author_name: Hannah Levin
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Mitchell J. Machiela
raw_affiliation_strings: Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Tongwu Zhang
raw_affiliation_strings: Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Goran Jonsson
raw_affiliation_strings: Division of Oncology, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, 22185, Sweden
Lund University Cancer Center, Lund, 22185, Sweden
Lund University
raw_author_name: D Timothy Bishop
raw_affiliation_strings: Leeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK
University of Leeds
raw_author_name: Julia Newton-Bishop
raw_affiliation_strings: Leeds Institute for Data Analytics, University of Leeds, Leeds, UK
University of Leeds
raw_author_name: Jeremie Nsengimana
raw_affiliation_strings: Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University and NIHR Biomedical Research Centre, Newcastle upon Tyne, UK
Newcastle University and NIHR Biomedical Research Centre
raw_author_name: Mark M. Iles
raw_affiliation_strings: Leeds Institute for Data Analytics, University of Leeds, Leeds, UK
NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
University of Leeds
raw_author_name: Maria Teresa Landi
raw_affiliation_strings: Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Matthew H. Law
raw_affiliation_strings: Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia
School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia
QIMR Berghofer Medical Research Institute
raw_author_name: Thorkell Andresson
raw_affiliation_strings: Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, MD, USA
Leidos Biomedical Research Inc
raw_author_name: Jiyeon Choi
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Leonard I. Zon
raw_affiliation_strings: Harvard Medical School, Boston, MA, USA
Stem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, MA, USA
Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA
Harvard Medical School
raw_author_name: Jianxin Shi
raw_affiliation_strings: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute
raw_author_name: Kevin M. Brown
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
National Cancer Institute