Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance
Year: 2025
Type: article
Language: en
Topic: Protein Kinase Regulation and GTPase Signaling
Authors and affiliations:
raw_author_name: Kristina Drizyte-Miller
raw_affiliation_strings: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Seamus E. Degan
raw_affiliation_strings: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Ryan D. Mouery
raw_affiliation_strings: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Amber M. Amparo
raw_affiliation_strings: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Brandon L. Mouery
raw_affiliation_strings: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Wen-Hsuan Chang
raw_affiliation_strings: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Runying Yang
raw_affiliation_strings: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Sheila R. Nicewarner Peña
raw_affiliation_strings: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia
raw_author_name: Elisa Baldelli
raw_affiliation_strings: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia
raw_author_name: Jeffrey A. Klomp
raw_affiliation_strings: Department of Medicine, Michigan State University, Grand Rapids, Michigan
raw_author_name: Edwin J. Iwanowicz
raw_affiliation_strings: Madera Therapeutics LLC, Chapel Hill, North Carolina
raw_author_name: Lee M. Graves
raw_affiliation_strings: Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Emanuel F. Petricoin
raw_affiliation_strings: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia
raw_author_name: Adrienne D. Cox
raw_affiliation_strings: Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Clint A. Stalnecker
raw_affiliation_strings: Department of Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Kirsten L. Bryant
raw_affiliation_strings: Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
raw_author_name: Channing J. Der
raw_affiliation_strings: Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina