3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility
Year: 2025
Type: article
Language: en
Topic: Genetic Associations and Epidemiology
Authors and affiliations:
raw_author_name: Khanh B. Trang
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: Prabhat Sharma
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Department of Pathology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
raw_author_name: Laura Cook
raw_affiliation_strings: Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia
Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia
Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
raw_author_name: Zachary Mount
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Department of Pathology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
raw_author_name: Rajan M. Thomas
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Department of Pathology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
raw_author_name: Nikhil N. Kulkarni
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Department of Pathology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
raw_author_name: Emylette Cruz Cabrera
raw_affiliation_strings: Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: Suzanna Rachimi
raw_affiliation_strings: Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: Matthew C. Pahl
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: James A. Pippin
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: Chun Su
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: Klaus H. Kaestner
raw_affiliation_strings: Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Joan M. O’Brien
raw_affiliation_strings: Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Penn Medicine Center for Ophthalmic Genetics in Complex Disease, Philadelphia, PA, USA
raw_author_name: Yadav Wagley
raw_affiliation_strings: Department of Orthopedic Surgery, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA
raw_author_name: Kurt D. Hankenson
raw_affiliation_strings: Department of Orthopedic Surgery, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA
raw_author_name: Ashley Jermusyk
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
raw_author_name: Jason W. Hoskins
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
raw_author_name: Laufey T. Amundadottir
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
raw_author_name: Mai Xu
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
raw_author_name: Kevin M. Brown
raw_affiliation_strings: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
raw_author_name: Stewart A. Anderson
raw_affiliation_strings: Department of Child and Adolescent Psychiatry, Children's Hospital of Philadelphia, Philadelphia, PA, USA
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Wenli Yang
raw_affiliation_strings: Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Paul M. Titchenell
raw_affiliation_strings: Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Patrick Seale
raw_affiliation_strings: Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Babette S. Zemel
raw_affiliation_strings: Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: Alessandra Chesi
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Department of Pathology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
raw_author_name: Neil Romberg
raw_affiliation_strings: Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA
Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
raw_author_name: Megan K. Levings
raw_affiliation_strings: BC Children's Hospital Research Institute, Vancouver, BC, Canada
Department of Surgery, University of British Columbia, Vancouver, BC, Canada
School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada
raw_author_name: Struan F. A. Grant
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Division Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Andrew D. Wells
raw_affiliation_strings: Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, 916E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA. adwells@pennmedicine.upenn.edu
Department of Pathology, Perelman School of Medicine, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA. adwells@pennmedicine.upenn.edu
Department of Pathology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA. adwells@pennmedicine.upenn.edu
Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA. adwells@pennmedicine.upenn.edu
Department of Pathology, Perelman School of Medicine, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA