HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement
Year: 2025
Type: article
Language: en
Topic: Cerebrovascular and genetic disorders
Authors and affiliations:
raw_author_name: Samaneh Farashi
raw_affiliation_strings: Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
raw_author_name: Carla J. Abbott
raw_affiliation_strings: Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia
raw_author_name: Brendan R. E. Ansell
raw_affiliation_strings: Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
raw_author_name: Zhichao Wu
raw_affiliation_strings: Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia
raw_author_name: Lebriz Altay
raw_affiliation_strings: Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany
Department of Ophthalmology, Duke University Medical Centre, Durham, NC, USA
raw_author_name: Ella Arnon
raw_affiliation_strings: Department of Ophthalmology, Duke University Medical Centre, Durham, NC, USA
Ophthalmology Department, University Hospital, Dijon, France
raw_author_name: Louis Arnould
raw_affiliation_strings: Ophthalmology Department, University Hospital, Dijon, France
Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases, (EA 7460), Faculty of Health Sciences, Université de Bourgogne, Dijon, France
Department of Ophthalmology, University of Washington, Seattle, WA, USA
raw_author_name: Yelena Bagdasarova
raw_affiliation_strings: Department of Ophthalmology, University of Washington, Seattle, WA, USA
Moorfields Eye Hospital NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK
raw_author_name: Konstantinos Balaskas
raw_affiliation_strings: Moorfields Eye Hospital NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK
Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia
raw_author_name: Fred K. Chen
raw_affiliation_strings: Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, WA, Australia
Department of Ophthalmology, Royal Perth Hospital, Perth, WA, Australia
Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia
Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
raw_author_name: Emily Chew
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Department of Ophthalmology, Hadassah Medical Centre and the Hebrew University of Jerusalem, Jerusalem, Israel
raw_author_name: Itay Chowers
raw_affiliation_strings: Department of Ophthalmology, Hadassah Medical Centre and the Hebrew University of Jerusalem, Jerusalem, Israel
Computational Sciences, Genentech Inc, South San Francisco, California, USA
raw_author_name: Steven Clarke
raw_affiliation_strings: Computational Sciences, Genentech Inc, South San Francisco, California, USA
Unit on Clinical Investigation of Retinal Diseases, National Eye Institute, National Institute of Health, Bethesda, MD, USA
raw_author_name: Catherine Cukras
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University of Bordeaux, INSERM, BPH, Bordeaux, France
raw_author_name: Cécile Delcourt
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raw_author_name: Marie-Noëlle Delyfer
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University of Bordeaux, INSERM, BPH, Bordeaux, France
Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands
raw_author_name: Anneke I. den Hollander
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Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany
raw_author_name: Sascha Fauser
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Roche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center, Basel, Switzerland
Department of Ophthalmology, University Hospital Bonn, Bonn, Germany
raw_author_name: Robert P. Finger
raw_affiliation_strings: Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Department of Ophthalmology, University Hospital Bonn, Bonn, Germany
Ophthalmology Department, University Hospital, Dijon, France
raw_author_name: Pierre-Henry Gabrielle
raw_affiliation_strings: Centre des Science du Goût et de l'Alimentation CNRS, INRA, Université Bourgogne Franche-Comte, Dijon, France
Ophthalmology Department, University Hospital, Dijon, France
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia
raw_author_name: Jiru Han
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Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
raw_author_name: Lauren A. B. Hodgson
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Department of Ophthalmology, University Hospital Bonn, Bonn, Germany
raw_author_name: Ruth Hogg
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Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands
raw_author_name: Frank G. Holz
raw_affiliation_strings: Department of Ophthalmology, University Hospital Bonn, Bonn, Germany
Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
raw_author_name: Carel Hoyng
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Department of Ophthalmology, Duke University Medical Centre, Durham, NC, USA
raw_author_name: Himeesh Kumar
raw_affiliation_strings: Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia
Department of Ophthalmology, University of Washington, Seattle, WA, USA
raw_author_name: Eleonora M. Lad
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Department of Ophthalmology, University Hospital Bonn, Bonn, Germany
raw_author_name: Aaron Lee
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Centre for Public Health, Queen's University Belfast Faculty of Medicine Health and Life Sciences, Belfast, UK
raw_author_name: Ulrich F. O. Luhmann
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Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, WA, Australia
raw_author_name: Matthias M. Mauschitz
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University of Bordeaux, INSERM, BPH, Bordeaux, France
raw_author_name: Amy J. McKnight
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Moorfields Eye Hospital NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK
raw_author_name: Samuel McLenachan
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Computational Sciences, Genentech Inc, South San Francisco, California, USA
raw_author_name: Aniket Mishra
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Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, WA, Australia
raw_author_name: Ismail Moghul
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Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia
raw_author_name: Luz D. Orozco
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Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany
raw_author_name: Danuta M. Sampson
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The University of Western Australia, The School of Allied Health, Optometry Division, Perth, WA, Australia
Department of Ophthalmology, University of Washington, Seattle, WA, USA
raw_author_name: Liam W. Scott
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Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Department of Human Genetics, Genentech Inc., South San Francisco, CA, USA
raw_author_name: Vasilena Sitnilska
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Neurobiology, Neurodegeneration & Repair Laboratory, National Eye Institute, Bethesda, MD, USA
raw_author_name: Scott Song
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Department of Ophthalmology, Hadassah Medical Centre and the Hebrew University of Jerusalem, Jerusalem, Israel
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Moorfields Eye Hospital NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK
raw_author_name: Anand Swaroop
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Department of Human Genetics, Genentech Inc., South San Francisco, CA, USA
raw_author_name: Jan H. Terheyden
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Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany
raw_author_name: Liran Tiosano
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Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands
raw_author_name: Adnan Tufail
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Roche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center, Basel, Switzerland
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Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
raw_author_name: L. Altay
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Department of Ophthalmology, University Hospital Bonn, Bonn, Germany
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Centre for Public Health, Queen's University Belfast Faculty of Medicine Health and Life Sciences, Belfast, UK
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Department of Anatomy and Physiology, The University of Melbourne, Parkville, VIC, Australia
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Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia
Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia
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Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
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AbbVie, Genomics Research Center, Cambridge, MA, USA
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Royal Melbourne Hospital, Department of Surgery, The University of Melbourne, Parkville, VIC, Australia
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Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia. rh.guymer@unimelb.edu.au
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Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. bahlo@wehi.edu.au
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