Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China
Year: 2025
Type: article
Language: en
Topic: Osteoarthritis Treatment and Mechanisms
Authors and affiliations:
raw_author_name: Xiaoshuai Wang
raw_affiliation_strings: Clinical Research Centre Zhujiang Hospital, Southern Medical University  Guangzhou Guangdong 510280 China
Department of Biomedical Engineering The Chinese University of Hong Kong Hong Kong 999077 China
Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, 999077 China
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
raw_author_name: Yi Liu
raw_affiliation_strings: Department of Radiation Oncology Sun Yat‐Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy  651 Dongfeng Road East Guangzhou Guangdong 510060 China
School of Medicine Shenzhen Campus of Sun Yat‐Sen University  Shenzhen Guangdong 518000 China
Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060 China
School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, 518000 China
raw_author_name: Ziying Sun
raw_affiliation_strings: Department of Orthopedics Nanjing Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu 210000 China
Department of Orthopedics, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210000 China
raw_author_name: Jia Li
raw_affiliation_strings: Division of Orthopaedic Surgery Department of Orthopaedics Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510000 China
Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510000 China
raw_author_name: Zhihao Lu
raw_affiliation_strings: Laboratory for Bone and Joint Disease, Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Pharmaceutical Biotechnology Nanjing University  321 Zhongshan Road Nanjing Jiangsu 210008 China
Laboratory for Bone and Joint Disease, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu, 210008 China
raw_author_name: Jiayuan Huang
raw_affiliation_strings: School of Medicine Shenzhen Campus of Sun Yat‐Sen University  Shenzhen Guangdong 518000 China
Shenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases Shenzhen Campus of Sun Yat‐Sen University  Shenzhen Guangdong 518000 China
School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, 518000 China
Shenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, 518000 China
raw_author_name: Shixian Hu
raw_affiliation_strings: Department of Gastroenterology The First Affiliated Hospital Sun Yat‐Sen University  Guangzhou Guangdong 510000 China
Institute of Precision Medicine The First Affiliated Hospital Sun Yat‐Sen University  Guangzhou Guangdong 510000 China
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510000 China
raw_author_name: Peihua Cao
raw_affiliation_strings: Clinical Research Centre Zhujiang Hospital, Southern Medical University  Guangzhou Guangdong 510280 China
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
raw_author_name: Xiaolong Cao
raw_affiliation_strings: Department of Anesthesiology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong 510280 China
Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
raw_author_name: Shangru Li
raw_affiliation_strings: Department of Oncology The First Affiliated Hospital Sun Yat‐Sen University  Guangzhou Guangdong 510000 China
Department of Orthopaedics The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University The Second Affiliated Chengdu Hospital of Chongqing Medical University  Chengdu Sichuan 610000 China
Department of Oncology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510000 China
raw_author_name: Jianzhao Ruan
raw_affiliation_strings: Clinical Research Centre Zhujiang Hospital, Southern Medical University  Guangzhou Guangdong 510280 China
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
raw_author_name: Jinhui Liu
raw_affiliation_strings: School of Medicine Shenzhen Campus of Sun Yat‐Sen University  Shenzhen Guangdong 518000 China
School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, Guangdong, 518000 China
raw_author_name: Jingyu Xie
raw_affiliation_strings: Department of Population &amp; Public Health Sciences Keck School of Medicine University of Southern California  Los Angeles CA 90089 USA
Department of Population & Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089 USA
raw_author_name: Haitao Sun
raw_affiliation_strings: Clinical Biobank Centre Microbiome Medicine Center Department of Laboratory Medicine Zhujiang Hospital Southern Medical University  Guangzhou Guangdong 510280 China
Neurosurgery Center Department of Cerebrovascular Surgery Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease The National Key Clinical Specialty Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration The Neurosurgery Institute of Guangdong Province Zhujiang Hospital Southern Medical University  Guangzhou Guangdong 510280 China
Clinical Biobank Centre, Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
raw_author_name: Tianyu Chen
raw_affiliation_strings: Department of Orthopedics The Third Affiliated Hospital of Southern Medical University  Guangzhou 510000 China
Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510000 China
raw_author_name: Shengfa Li
raw_affiliation_strings: Department of Oncology The First Affiliated Hospital Sun Yat‐Sen University  Guangzhou Guangdong 510000 China
Department of Orthopaedics The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University The Second Affiliated Chengdu Hospital of Chongqing Medical University  Chengdu Sichuan 610000 China
Department of Orthopaedics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, The Second Affiliated Chengdu Hospital of Chongqing Medical University, Chengdu, Sichuan, 610000 China
raw_author_name: Zhaohua Zhu
raw_affiliation_strings: Clinical Research Centre Zhujiang Hospital, Southern Medical University  Guangzhou Guangdong 510280 China
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
raw_author_name: Zhibo Wen
raw_affiliation_strings: Department of Radiology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong 510280 China
Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
raw_author_name: Rocky S. Tuan
raw_affiliation_strings: Department of Biomedical Engineering The Chinese University of Hong Kong Hong Kong 999077 China
Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, 999077 China
raw_author_name: David John Hunter
raw_affiliation_strings: Clinical Research Centre Zhujiang Hospital, Southern Medical University  Guangzhou Guangdong 510280 China
Department of Rheumatology Royal North Shore Hospital and Sydney Musculoskeletal Health Kolling Institute University of Sydney  Sydney New South Wales 2006 Australia
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China
Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, New South Wales, 2006 Australia
raw_author_name: Zhong Alan Li
raw_affiliation_strings: Department of Biomedical Engineering The Chinese University of Hong Kong Hong Kong 999077 China
State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  NT Hong Kong China
State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, NT, Hong Kong, China
raw_author_name: Dongquan Shi
raw_affiliation_strings: Laboratory for Bone and Joint Disease, Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Pharmaceutical Biotechnology Nanjing University  321 Zhongshan Road Nanjing Jiangsu 210008 China
Laboratory for Bone and Joint Disease, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu, 210008 China
raw_author_name: Changhai Ding
raw_affiliation_strings: Clinical Research Centre Beijing Tsinghua Changgung Hospital Tsinghua Medicine Tsinghua University  Beijing 102218 China
Clinical Research Centre Zhujiang Hospital, Southern Medical University  Guangzhou Guangdong 510280 China
Menzies Institute for Medical Research University of Tasmania  Hobart Tasmania 7005 Australia
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, 7005 Australia
Clinical Research Centre, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, 102218 China
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280 China