IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody
Year: 2025
Type: article
Language: en
Topic: SARS-CoV-2 and COVID-19 Research
Authors and affiliations:
raw_author_name: Niannian Lv
raw_affiliation_strings: Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China
Research Unit of Nanoscience and Technology Chinese Academy of Medical Sciences Beijing 100730 China
Research Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing, 100730 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 China
raw_author_name: Peng Chen
raw_affiliation_strings: Comprehensive AIDS Research Center Pandemic Research Alliance Unit Center for Infection Biology School of Basic Medical Sciences Tsinghua University  Beijing 100084 China
Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084 China
raw_author_name: Xiaobin Dai
raw_affiliation_strings: State Key Laboratory of Chemical Engineering and Low‐carbon Technology Department of Chemical Engineering and Low‐carbon Technology Tsinghua University Beijing 100084 China
State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering and Low-carbon Technology, Tsinghua University, Beijing, 100084 China
raw_author_name: Hu Xu
raw_affiliation_strings: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences Beijing 100190 China
College of Ecology Lanzhou University Lanzhou 730000 China
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100190 China
College of Ecology, Lanzhou University, Lanzhou, 730000 China
raw_author_name: Ziheng Li
raw_affiliation_strings: Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100049 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
raw_author_name: Zelin Shan
raw_affiliation_strings: The Salk Institute of Biological Sciences La Jolla CA 92037 USA
The Salk Institute of Biological Sciences, La Jolla, CA, 92037 USA
raw_author_name: Jinqian Li
raw_affiliation_strings: Comprehensive AIDS Research Center Pandemic Research Alliance Unit Center for Infection Biology School of Basic Medical Sciences Tsinghua University  Beijing 100084 China
Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100049 China
Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084 China
raw_author_name: Fenglin Guo
raw_affiliation_strings: The Ministry of Education Key Laboratory of Protein Science Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University  Beijing 100084 China
The Ministry of Education Key Laboratory of Protein Science, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, 100084 China
raw_author_name: Yuanfang Chen
raw_affiliation_strings: Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100049 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
raw_author_name: Jiayi Li
raw_affiliation_strings: Comprehensive AIDS Research Center Pandemic Research Alliance Unit Center for Infection Biology School of Basic Medical Sciences Tsinghua University  Beijing 100084 China
Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100049 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
raw_author_name: Yiqian Huang
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University of Chinese Academy of Sciences Beijing 100049 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
raw_author_name: Guizhi Dong
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CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 China
raw_author_name: Yifan Jiang
raw_affiliation_strings: MOE Engineering Research Center of Advanced Rare Earth Materials Department of Chemistry Tsinghua University  Beijing 100084 China
MOE Engineering Research Center of Advanced Rare Earth Materials, Department of Chemistry, Tsinghua University, Beijing, 100084 China
raw_author_name: Liang Chen
raw_affiliation_strings: Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100049 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
raw_author_name: Xuanyu Nan
raw_affiliation_strings: Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
raw_author_name: Hanjun Zhao
raw_affiliation_strings: Centre for Virology Vaccinology and Therapeutics Department of Microbiology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR 999077 China
Shanghai Institute of Infectious Disease and Biosecurity Shanghai Medical College Fudan University Shanghai 200032 China
Centre for Virology, Vaccinology and Therapeutics, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, 999077 China
Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Medical College, Fudan University, Shanghai, 200032 China
raw_author_name: Kang Zhang
raw_affiliation_strings: Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China
raw_author_name: Shilong Fan
raw_affiliation_strings: The technology center for protein science Tsinghua University Beijing 100084 China
The technology center for protein science, Tsinghua University, Beijing, 100084 China
raw_author_name: Yuanchen Dong
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CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 China
raw_author_name: Dongsheng Liu
raw_affiliation_strings: Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University  Hong Hum Kowloon 999077 Hong Kong
MOE Engineering Research Center of Advanced Rare Earth Materials Department of Chemistry Tsinghua University  Beijing 100084 China
PolyU Shenzhen Research Institute  Shenzhen 518057 China
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Hum, Kowloon, 999077 Hong Kong
PolyU Shenzhen Research Institute, Shenzhen, 518057 China
MOE Engineering Research Center of Advanced Rare Earth Materials, Department of Chemistry, Tsinghua University, Beijing, 100084 China
raw_author_name: Xinquan Wang
raw_affiliation_strings: The Ministry of Education Key Laboratory of Protein Science Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University  Beijing 100084 China
The Ministry of Education Key Laboratory of Protein Science, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, 100084 China
raw_author_name: Deli Huang
raw_affiliation_strings: Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences Institute Zhejiang University  Hangzhou 310058 China
Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058 China
raw_author_name: Xiaojing Pan
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Institute of Bio-Architecture and Bio-Interactions, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong, 518107 China
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Research Unit of Nanoscience and Technology Chinese Academy of Medical Sciences Beijing 100730 China
University of Chinese Academy of Sciences Beijing 100049 China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Research Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing, 100730 China
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National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China
Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing, 100142 China
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 China
raw_author_name: Li‐Tang Yan
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State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering and Low-carbon Technology, Tsinghua University, Beijing, 100084 China
raw_author_name: Qi Zhang
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Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084 China
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Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory  Shenzhen 518132 China
Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen 518055 China
Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132 China
Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084 China
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055 China
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National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China
Research Unit of Nanoscience and Technology Chinese Academy of Medical Sciences Beijing 100730 China
University of Chinese Academy of Sciences Beijing 100049 China
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, Beijing, 100190 China
Research Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing, 100730 China
University of Chinese Academy of Sciences, Beijing, 100049 China
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University of Chinese Academy of Sciences Beijing 100049 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, 100190 China