Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma
Year: 2025
Type: article
Language: en
Topic: Immune cells in cancer
Authors and affiliations:
raw_author_name: Nathalie Babl
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: nathalie.babl@ukr.de
raw_author_name: Florian Voll
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Agnieszka Martowicz
raw_affiliation_strings: Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria
raw_author_name: Christina Bruss
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Marianna Maddaloni
raw_affiliation_strings: Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Christian Schmidl
raw_affiliation_strings: Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Michael Rehli
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Stefan Loipfinger
raw_affiliation_strings: Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Nicholas Strieder
raw_affiliation_strings: Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Claudia Gebhard
raw_affiliation_strings: Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Petra Hoffmann
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Sukh M. Singh
raw_affiliation_strings: School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India
raw_author_name: Ada Sala-Hojman
raw_affiliation_strings: Merck Healthcare KGaA, Darmstadt, Germany
raw_author_name: Roberta Ferretti
raw_affiliation_strings: EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA
raw_author_name: Carina Matos
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
raw_author_name: Malte Simon
raw_affiliation_strings: Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
raw_author_name: Christina Brummer
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Annette Schnell
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Joshua Hofbauer
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Sonja-Maria Decking
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Peter Hau
raw_affiliation_strings: Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Arabel Vollmann-Zwerenz
raw_affiliation_strings: Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Katja Dettmer
raw_affiliation_strings: Institute of Functional Genomics, University of Regensburg, Regensburg, Germany
raw_author_name: Peter J. Oefner
raw_affiliation_strings: Institute of Functional Genomics, University of Regensburg, Regensburg, Germany
raw_author_name: Michael Althammer
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Johanna Laufs
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Sarah Friedl
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Timo Heinrich
raw_affiliation_strings: Merck Healthcare KGaA, Darmstadt, Germany
raw_author_name: Christian Herhaus
raw_affiliation_strings: Merck Healthcare KGaA, Darmstadt, Germany
raw_author_name: Katja Evert
raw_affiliation_strings: Institute of Pathology, University of Regensburg, Regensburg, Germany
raw_author_name: Roman Mayr
raw_affiliation_strings: Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany
raw_author_name: Julieta Afonso
raw_affiliation_strings: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal
raw_author_name: Fatima Baltazar
raw_affiliation_strings: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal
raw_author_name: Wolfgang Herr
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Peter J. Siska
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Kathrin Renner
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany
raw_author_name: Marina Kreutz
raw_affiliation_strings: Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: marina.kreutz@ukr.de