CRISPR-free RNA base editing mediated PTC-readthrough restores hearing in mice with Otof nonsense mutation
Year: 2025
Type: article
Language: en
Topic: RNA regulation and disease
Authors and affiliations:
raw_author_name: Hanxiao Sun
raw_affiliation_strings: The National Key Laboratory of Gene Function Studies and Manipulation, School of Life Sciences, Peking University, Beijing, China
raw_author_name: Qi Teng
raw_affiliation_strings: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
raw_author_name: Wenqing Liu
raw_affiliation_strings: School of Life Sciences, Tsinghua University, Beijing, China
Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing, China
raw_author_name: Rui Guo
raw_affiliation_strings: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
raw_author_name: Menghua Li
raw_affiliation_strings: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
raw_author_name: Wei Xiong
raw_affiliation_strings: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
raw_author_name: Qiang Huang
raw_affiliation_strings: The National Key Laboratory of Gene Function Studies and Manipulation, School of Life Sciences, Peking University, Beijing, China
raw_author_name: Qianru Yu
raw_affiliation_strings: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
raw_author_name: Nan Luo
raw_affiliation_strings: The National Key Laboratory of Gene Function Studies and Manipulation, School of Life Sciences, Peking University, Beijing, China
raw_author_name: Yang Li
raw_affiliation_strings: Beijing Clinical Research Institute, Beijing, China
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
raw_author_name: Jinghui Song
raw_affiliation_strings: The National Key Laboratory of Gene Function Studies and Manipulation, School of Life Sciences, Peking University, Beijing, China
raw_author_name: Shusheng Gong
raw_affiliation_strings: Clinical Center for Hearing Loss, Capital Medical University, Beijing, China
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
raw_author_name: Xi Shi
raw_affiliation_strings: Academician Workstation of Hainan University (Sanya), School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan, China. shixi2023@hainanu.edu.cn
Academician Workstation of Hainan University (Sanya), School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan, China
raw_author_name: Chengqi Yi
raw_affiliation_strings: Beijing Advanced Center of RNA Biology (BEACON), Peking University, Beijing, China. chengqi.yi@pku.edu.cn
Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. chengqi.yi@pku.edu.cn
Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. chengqi.yi@pku.edu.cn
The National Key Laboratory of Gene Function Studies and Manipulation, School of Life Sciences, Peking University, Beijing, China. chengqi.yi@pku.edu.cn
Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
raw_author_name: Ke Liu
raw_affiliation_strings: Beijing Clinical Research Institute, Beijing, China. liuke@ccmu.edu.cn
Clinical Center for Hearing Loss, Capital Medical University, Beijing, China. liuke@ccmu.edu.cn
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. liuke@ccmu.edu.cn
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Beijing Clinical Research Institute, Beijing, China