KRAS-Driven Hypertranscription and Metastatic Dissemination in Colorectal Cancer Could be Overcome by Targeting the NMHC IIA/ PLK1 Signaling Axis with a Novel Acridine Derivative
Year: 2025
Type: article
Language: en
Topic: PI3K/AKT/mTOR signaling in cancer
Authors and affiliations:
raw_author_name: Dengbo Ji
raw_affiliation_strings: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd., Haidian District, Beijing, China, 100142
raw_author_name: Haizhao Yi
raw_affiliation_strings: Department of General Surgery, Affiliated Hospital of Chengde Medical College, Chengde, China
raw_author_name: Ming Li
raw_affiliation_strings: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd., Haidian District, Beijing, China, 100142
raw_author_name: Zhaoya Gao
raw_affiliation_strings: Peking University S.G. Hospital, Beijing, China
raw_author_name: Rui Yang
raw_affiliation_strings: The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China, 100191
raw_author_name: Jingying Jia
raw_affiliation_strings: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd., Haidian District, Beijing, China, 100142
raw_author_name: Xinxin Cui
raw_affiliation_strings: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd., Haidian District, Beijing, China, 100142
raw_author_name: Can Song
raw_affiliation_strings: Peking-Tsinghua Center for Life Sciences, Beijing, China
School of Life Sciences, Tsinghua University, Beijing, China, 100084
raw_author_name: Hanyang Wang
raw_affiliation_strings: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd., Haidian District, Beijing, China, 100142
raw_author_name: Mengyuan Shi
raw_affiliation_strings: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd., Haidian District, Beijing, China, 100142
raw_author_name: Yuhao Yan
raw_affiliation_strings: The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China, 100191
raw_author_name: Tongtong Geng
raw_affiliation_strings: The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China, 100191
raw_author_name: Xiangbao Meng
raw_affiliation_strings: The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China, 100191
raw_author_name: Zhongjun Li
raw_affiliation_strings: The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China, 100191
raw_author_name: Jin Gu
raw_affiliation_strings: Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd., Haidian District, Beijing, China, 100142
Peking University S.G. Hospital, Beijing, China
Peking-Tsinghua Center for Life Sciences, Beijing, China
School of Life Sciences, Tsinghua University, Beijing, China, 100084