Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
Year: 2025
Type: article
Language: en
Topic: Acute Myeloid Leukemia Research
Authors and affiliations:
raw_author_name: Mark Hartmann
raw_affiliation_strings: German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
German Cancer Research Center, DKFZ, Heidelberg, Germany
raw_author_name: Maximilian Schönung
raw_affiliation_strings: 3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
German Cancer Research Center, Heidelberg, Germany
raw_author_name: Jovana Rajak
raw_affiliation_strings: 5Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
University of Freiburg 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, , Freiburg, Germany
University Medical Center Freiburg, Freiburg, Germany
raw_author_name: Valentin Maurer
raw_affiliation_strings: 6European Molecular Biology Laboratory Hamburg, Hamburg, Germany
7Centre for Structural Systems Biology (CSSB), Hamburg, Germany
German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
German Cancer Research Center, DKFZ, Heidelberg, Germany
raw_author_name: Ling Hai
raw_affiliation_strings: German Cancer Research Center (DKFZ) 8 Bioinformatics and Omics Data Analytics, , Heidelberg, Germany
German Cancer Research Center, Germany
raw_author_name: Katharina Bauer
raw_affiliation_strings: German Cancer Research Center (DKFZ) 9 scOPEN Lab, , Heidelberg, Germany
German Cancer Research Center, Heidelberg, Germany
raw_author_name: Mariam Hakobyan
raw_affiliation_strings: 3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
German Cancer Research Center, Heidelberg, Germany
raw_author_name: Sina Stäble
raw_affiliation_strings: 3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
German Cancer Research Center, Heidelberg, 69120, Germany
raw_author_name: Jens Langstein
raw_affiliation_strings: 3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
AstraZeneca, Toronto, Canada, United States
raw_author_name: Laura Jardine
raw_affiliation_strings: Newcastle University 10 Biosciences Institute, , Newcastle upon Tyne, United Kingdom
Newcastle University, United Kingdom
raw_author_name: Roland Roelz
raw_affiliation_strings: University of Freiburg 11 Department of Neurosurgery, Medical Center, Faculty of Medicine, , Freiburg, Germany
University of Freiburg, Freiburg, Germany
raw_author_name: Sheila Bohler
raw_affiliation_strings: University of Freiburg 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, , Freiburg, Germany
University Medical Center Freiburg, Freiburg, Germany
raw_author_name: Eleonora Khabirova
raw_affiliation_strings: Wellcome Sanger Institute 12 , Hinxton, United Kingdom
Wellcome Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
raw_author_name: Abdul-Habib Maag
raw_affiliation_strings: University Hospital of Ulm 13 Institute of Experimental Cancer Research, , Ulm, Germany
University Hospital Ulm, Ulm, Germany
raw_author_name: Dominik Vonficht
raw_affiliation_strings: 15Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany
3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
German Cancer Research Center (DKFZ) 14 Division of Stem Cells and Cancer, and DKFZ-ZMBH Alliance, Heidelberg, Germany
German Cancer Research Center, Berlin, Germany
raw_author_name: Dirk Lebrecht
raw_affiliation_strings: University of Freiburg 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, , Freiburg, Germany
University Medical Center Freiburg, Freiburg, Germany
raw_author_name: Kathrin M. Bernt
raw_affiliation_strings: Children’s Hospital of Philadelphia 16 Division of Pediatric Oncology, , Philadelphia, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, PA, United States
raw_author_name: Kai Tan
raw_affiliation_strings: 18Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania
The Children’s Hospital of Philadelphia 17 Center for Childhood Cancer Research, , Philadelphia, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, PA, United States
raw_author_name: Changya Chen
raw_affiliation_strings: 18Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania
The Children’s Hospital of Philadelphia 17 Center for Childhood Cancer Research, , Philadelphia, Pennsylvania
Children's Hospital of Philadelphia, United States
raw_author_name: Fatemeh Alikarami
raw_affiliation_strings: Children’s Hospital of Philadelphia 19 Division of Oncology and Center for Childhood Cancer Research, , Philadelphia, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, United States
raw_author_name: Julia Meyer
raw_affiliation_strings: University of California San Francisco 20 Department of Pediatrics, Benioff Children’s Hospitals, , San Francisco, California
UCSF Benioff Children's Hospital, San Francisco, CA, United States
raw_author_name: Jun Wang
raw_affiliation_strings: 5Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
University of Freiburg 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, , Freiburg, Germany
University of Freiburg, China
raw_author_name: Tobias Boch
raw_affiliation_strings: 21Department of Hematology and Oncology, Heidelberg University, University Hospital Mannheim, Mannheim, Germany
Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Viktoria Flore
raw_affiliation_strings: German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
German Cancer Research Center, Germany
raw_author_name: Pavlo Lutsik
raw_affiliation_strings: German Cancer Research Center (DKFZ) 22 Division of Cancer Epigenomics, , Heidelberg, Germany
KU Leuven, Leuven, Belgium
raw_author_name: Michael D. Milsom
raw_affiliation_strings: 15Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany
German Cancer Research Center (DKFZ) 23 Division of Experimental Hematology, , Heidelberg, Germany
German Cancer Research Center, Heidelberg, Germany
raw_author_name: Simon Raffel
raw_affiliation_strings: University Hospital Heidelberg 24 Department of Medicine, Hematology, Oncology and Rheumatology, , Heidelberg, Germany
University Hospital Heidelberg, Heidelberg, Germany
raw_author_name: Christian Buske
raw_affiliation_strings: University Hospital of Ulm 13 Institute of Experimental Cancer Research, , Ulm, Germany
University Hospital Ulm, Ulm, Germany
raw_author_name: Simon Haas
raw_affiliation_strings: 25Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom
27Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center in the Helmholtz Association, Berlin, Germany
Charité - Universitätsmedizin Berlin 26 Berlin Institute of Health (BIH), , Berlin, Germany
Charité - Universitätsmedizin Berlin, Berlin, Germany
raw_author_name: Muzlifah Haniffa
raw_affiliation_strings: Newcastle University 10 Biosciences Institute, , Newcastle upon Tyne, United Kingdom
Wellcome Sanger Institute 12 , Hinxton, United Kingdom
Wellcome Sanger Institute, Cambridge, United Kingdom
raw_author_name: Jan-Philipp Mallm
raw_affiliation_strings: German Cancer Research Center (DKFZ) 9 scOPEN Lab, , Heidelberg, Germany
German Cancer Research Center, Heidelberg, Germany
raw_author_name: Sam Behjati
raw_affiliation_strings: 28Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
29Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom
Wellcome Sanger Institute 12 , Hinxton, United Kingdom
Wellcome Trust Sanger Institute, Cambridgeshire, United Kingdom
raw_author_name: Marc-Jan Bonder
raw_affiliation_strings: 31Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
German Cancer Research Center 30 Division of Computational Genomics and Systems Genetics, , Heidelberg, Germany
German Cancer Research Center, Germany
raw_author_name: Stefan Fröhling
raw_affiliation_strings: 33German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany
34Institute of Human Genetics, Heidelberg University, Heidelberg, Germany
German Cancer Research Center (DKFZ) 32 Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
National Center for Tumor Diseases, Heidelberg, Germany
raw_author_name: Elliot Stieglitz
raw_affiliation_strings: University of California San Francisco 20 Department of Pediatrics, Benioff Children’s Hospitals, , San Francisco, California
University of California, San Francisco, San Francisco, California, United States
raw_author_name: Charlotte M. Niemeyer
raw_affiliation_strings: University of Freiburg 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, , Freiburg, Germany
a partnership between DKFZ and University Medical Center Freiburg 35 German Cancer Consortium (DKTK), partner site Freiburg, , Freiburg, Germany
University of Freiburg, Freiburg, Germany
raw_author_name: Joschka Hey
raw_affiliation_strings: 36German-Israeli Helmholtz International Research School in Cancer Biology, Heidelberg, Germany
German Cancer Research Center (DKFZ) 22 Division of Cancer Epigenomics, , Heidelberg, Germany
German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany
raw_author_name: Christian Flotho
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a partnership between DKFZ and University Medical Center Freiburg 35 German Cancer Consortium (DKTK), partner site Freiburg, , Freiburg, Germany
University Medical Center Freiburg, Freiburg, Germany
raw_author_name: Christoph Plass
raw_affiliation_strings: German Cancer Research Center (DKFZ) 22 Division of Cancer Epigenomics, , Heidelberg, Germany
German Cancer Research Center, Heidelberg, Germany
raw_author_name: Miriam Erlacher
raw_affiliation_strings: 5Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
University of Freiburg 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, , Freiburg, Germany
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University Medical Center Freiburg, Freiburg, Germany
raw_author_name: Matthias Schlesner
raw_affiliation_strings: German Cancer Research Center (DKFZ) 8 Bioinformatics and Omics Data Analytics, , Heidelberg, Germany
University of Augsburg 37 Faculty of Applied Computer Sciences, Biomedical Informatics, Data Mining and Data Analytics, , Augsburg, Germany
University of Augsburg, Augsburg, Germany
raw_author_name: Daniel B. Lipka
raw_affiliation_strings: 33German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany
38Faculty of Medicine, Otto-von-Guericke-University, Magdeburg, Germany
German Cancer Research Center (DKFZ) 1 Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, , Heidelberg, Germany
National Center for Tumor Diseases (NCT) 2 , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
German Cancer Research Center, Heidelberg, Germany