Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 Inhibitor
Year: 2025
Type: article
Language: en
Topic: Advanced Breast Cancer Therapies
Authors and affiliations:
raw_author_name: Gary M. Gallego
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Cynthia Palmer
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Suvi Orr
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Louise Bernier
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Ping Chen
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Sujin Cho-Schultz
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Judith G. Deal
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Klaus Dress
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Martin Edwards
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Mehran Jalaie
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Eric Johnson
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Robert Kania
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: John C. Kath
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Jennifer Lafontaine
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Sacha Ninkovic
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Neal Sach
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Hong Shen
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Lars Anders
raw_affiliation_strings: Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Britton Boras
raw_affiliation_strings: Pharmacokinetics and Dynamics, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Fengjuan Cao
raw_affiliation_strings: Medicinal Sciences, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Julie A. Cianfrogna
raw_affiliation_strings: Pharmacokinetics and Dynamics, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Loretta Cox
raw_affiliation_strings: Pfizer Worldwide Research and Development
Pharmacokinetics and Dynamics
raw_author_name: Lisa Marroquin
raw_affiliation_strings: Pfizer Worldwide Research and Development
Toxicology
raw_author_name: Bernadette Pascual
raw_affiliation_strings: Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Matthew Petroski
raw_affiliation_strings: Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Casey Quinlan
raw_affiliation_strings: Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Aida Sacaan
raw_affiliation_strings: Toxicology, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Na Wei
raw_affiliation_strings: Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States
raw_author_name: Sajiv K. Nair
raw_affiliation_strings: Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, La Jolla, San Diego, California 92121, United States