Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Year: 2025
Type: article
Language: en
Topic: Hemoglobinopathies and Related Disorders
Authors and affiliations:
raw_author_name: Yijie Shen
raw_affiliation_strings: Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University  130 Dong'An Road Shanghai 200032 China
raw_author_name: Jiale Wei
raw_affiliation_strings: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  No.1 Xiangshan Road Hangzhou 310024 China
raw_author_name: Shibing Tang
raw_affiliation_strings: Institute of Drug Discovery China‐New Zealand Joint Laboratory on Biomedicine and Health Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  190 Kaiyuan Avenue Guangzhou 510530 China
raw_author_name: Dongliang Wu
raw_affiliation_strings: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences Nanjing University  Nanjing 210023 China
raw_author_name: Liangyi Zong
raw_affiliation_strings: Institute of Drug Discovery China‐New Zealand Joint Laboratory on Biomedicine and Health Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  190 Kaiyuan Avenue Guangzhou 510530 China
raw_author_name: Shuyuan Ma
raw_affiliation_strings: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  No.1 Xiangshan Road Hangzhou 310024 China
raw_author_name: Qing Xiong
raw_affiliation_strings: GMU‐GIBH Joint School of Life Sciences, The Guangdong‐Hong Kong‐Macao Joint Laboratory for Cell Fate Regulation and Diseases Guangzhou Medical University Guangzhou 511436 China
raw_author_name: Ruijie Gong
raw_affiliation_strings: Department of Hepatobiliary Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Institutes of Biomedical Sciences, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism Zhongshan Hospital Fudan University  Shanghai 200032 China
raw_author_name: Siyuan Xu
raw_affiliation_strings: Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University  130 Dong'An Road Shanghai 200032 China
raw_author_name: Chuxuan Peng
raw_affiliation_strings: Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University  130 Dong'An Road Shanghai 200032 China
raw_author_name: Qin Feng
raw_affiliation_strings: Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University  130 Dong'An Road Shanghai 200032 China
raw_author_name: Songchen Liu
raw_affiliation_strings: Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University  130 Dong'An Road Shanghai 200032 China
raw_author_name: Qitong Liu
raw_affiliation_strings: Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University  130 Dong'An Road Shanghai 200032 China
raw_author_name: Yuhua Ye
raw_affiliation_strings: Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Department of Medical Genetics, School of Basic Medical Sciences Southern Medical University  Guangzhou Guangdong 510515 China
raw_author_name: Quan Zhao
raw_affiliation_strings: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences Nanjing University  Nanjing 210023 China
raw_author_name: Cheng Luo
raw_affiliation_strings: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  No.1 Xiangshan Road Hangzhou 310024 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zuchongzhi Road Shanghai 201203 China
raw_author_name: Peng Huang
raw_affiliation_strings: GMU‐GIBH Joint School of Life Sciences, The Guangdong‐Hong Kong‐Macao Joint Laboratory for Cell Fate Regulation and Diseases Guangzhou Medical University Guangzhou 511436 China
raw_author_name: Zhihai Li
raw_affiliation_strings: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  No.1 Xiangshan Road Hangzhou 310024 China
raw_author_name: Xiangqian Kong
raw_affiliation_strings: Institute of Drug Discovery China‐New Zealand Joint Laboratory on Biomedicine and Health Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences  190 Kaiyuan Avenue Guangzhou 510530 China
raw_author_name: Xianjiang Lan
raw_affiliation_strings: Department of Systems Biology for Medicine, School of Basic Medical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University  130 Dong'An Road Shanghai 200032 China