Ligand-based design and optimization of tecovirimat derivatives as potent antiviral agents against monkeypox virus
Year: 2025
Type: article
Language: en
Topic: Poxvirus research and outbreaks
Authors and affiliations:
raw_author_name: Yuanguang Chen
raw_affiliation_strings: Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, Shenzhen Grubbs Institute and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China; Shenzhen AntiV Pharma Co., Ltd., Shenzhen, Guangdong, 518081, China
raw_author_name: Sumei Yang
raw_affiliation_strings: Institute for Hepatology, National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518112, China
raw_author_name: Xingyu Zhou
raw_affiliation_strings: Department of Computer Science and Engineering, Southern University of Science and Technology, Shenzhen, 518000, China
raw_author_name: Hongyang Yi
raw_affiliation_strings: Institute for Hepatology, National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518112, China
raw_author_name: Dizhen Liang
raw_affiliation_strings: Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, Shenzhen Grubbs Institute and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China
raw_author_name: Guanguan Li
raw_affiliation_strings: Shenzhen AntiV Pharma Co., Ltd., Shenzhen, Guangdong, 518081, China
raw_author_name: Xiang Liu
raw_affiliation_strings: Institute for Hepatology, National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518112, China
raw_author_name: Peisen Zheng
raw_affiliation_strings: Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, Shenzhen Grubbs Institute and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China
raw_author_name: Yongqing Liu
raw_affiliation_strings: Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, Shenzhen Grubbs Institute and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China
raw_author_name: Xinshan Deng
raw_affiliation_strings: Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, Hunan, 410219, China
raw_author_name: Xumu Zhang
raw_affiliation_strings: Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, Shenzhen Grubbs Institute and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China. Electronic address: zhangxm@sustech.edu.cn
raw_author_name: Qifan Zhou
raw_affiliation_strings: Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, Shenzhen Grubbs Institute and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China. Electronic address: zhouqf@sustech.edu.cn
raw_author_name: Hongzhou Lu
raw_affiliation_strings: Institute for Hepatology, National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518112, China. Electronic address: luhongzhou@fudan.edu.cn