Trabectedin–olaparib combination or trabectedin in advanced soft tissue sarcomas after failure of anthracycline-based treatment (TOMAS2): a randomized phase II study from the Italian Sarcoma Group
Year: 2025
Type: article
Language: en
Topic: Sarcoma Diagnosis and Treatment
Authors and affiliations:
raw_author_name: L. D’Ambrosio
raw_affiliation_strings: Department of Oncology, University of Torino; Regione Gonzole 10 - 10043 Orbassano (TO), Italy; AOU San Luigi Gonzaga; Regione Gonzole 10 - 10043 Orbassano (TO), Italy. Electronic address: lorenzo.dambrosio@unito.it
raw_author_name: A. Merlini
raw_affiliation_strings: Department of Oncology, University of Torino, Orbassano, Torino, Italy; AOU San Luigi Gonzaga, Orbassano, Torino, Italy
Department of Oncology, University of Torino; Regione Gonzole 10 - 10043 Orbassano (TO), Italy; AOU San Luigi Gonzaga; Regione Gonzole 10 - 10043 Orbassano (TO), Italy
raw_author_name: A. Brunello
raw_affiliation_strings: Medical Oncology 1 Unit, Department of Medical Oncology, Istituto Oncologico Veneto IOV IRCCS, Padova, Italy
Medical Oncology 1 Unit, Department of Medical Oncology, Istituto Oncologico Veneto IOV IRCCS; Via Gattamelata, 64 - 35128 Padova, Italy
raw_author_name: V. Ferraresi
raw_affiliation_strings: Department of Sarcomas and Rare Tumors Departmental Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy
Department of Sarcomas and Rare Tumors Departmental Unit, IRCCS Regina Elena National Cancer Institute; Via Chianesi 53 - 00144 Rome, Italy
raw_author_name: A. Paioli
raw_affiliation_strings: Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
raw_author_name: B. Vincenzi
raw_affiliation_strings: Department of Medical Oncology, Policlinico Universitario Campus Bio-Medico and Università Campus Bio-Medico, Roma, Italy
Department of Medical Oncology, Policlinico Universitario Campus Bio-Medico and Università Campus Bio-Medico, via Álvaro del Portillo 200 - 00128 Roma, Italy
raw_author_name: M.A. Pantaleo
raw_affiliation_strings: Department of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy
Department of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna; Via Giuseppe Massarenti, 9 - 40138 Bologna, Italy
raw_author_name: T.M. De Pas
raw_affiliation_strings: Department of Medical Oncology, IRCCS Istituto Europeo Oncologia, Milano, Italy; Division of Medical Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy
Department of Medical Oncology, IRCCS Istituto Europeo Oncologia; Via Giuseppe Ripamonti 435 - 20141 Milano, Italy; Division of Medical Oncology, Cliniche Humanitas Gavazzeni, Via M. Gavazzeni 21, 24125, Bergamo, Italy
raw_author_name: L. Gurrieri
raw_affiliation_strings: Experimental and Clinical Oncology of Immunotherapy and Rare Cancers, Biobank Unit, IRCCS Istituto Romagnolo per la Studio dei Tumori Dino Amadori, Meldola, Italy
Experimental and Clinical Oncology of Immunotherapy and Rare Cancers, Biobank Unit, IRCCS Istituto Romagnolo per la Studio dei Tumori Dino Amadori; Via Piero Maroncelli 40 - 47014 Meldola, Italy Meldola
raw_author_name: R. Sanfilippo
raw_affiliation_strings: Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori; Via G Venezian 1 - 20133 Milano, Italy
raw_author_name: A. Buonadonna
raw_affiliation_strings: Medical Oncology, IRCCS Centro di Riferimento Oncologico di Aviano, Aviano, Italy
Medical Oncology, IRCCS Centro di Riferimento Oncologico di Aviano; Via Franco Gallini 2 - 33081 Aviano (PN), Italy
raw_author_name: G.G. Baldi
raw_affiliation_strings: Department of Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy
Department of Oncology, Hospital of Prato, Azienda USL Toscana Centro; Via Suor Niccolina Infermiera 20/22 - 59100 Prato, Italy
raw_author_name: G. Badalamenti
raw_affiliation_strings: Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), Section of Medical Oncology, University of Palermo, Palermo, Italy
Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), Section of Medical Oncology, University of Palermo; Via Liborio Giuffrè 5 - 90127 Palermo, Italy
raw_author_name: C. Marchiò
raw_affiliation_strings: Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy
Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy
raw_author_name: Y. Pignochino
raw_affiliation_strings: Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy
Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy
raw_author_name: E. Berrino
raw_affiliation_strings: Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy
Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy
raw_author_name: S.E. Bellomo
raw_affiliation_strings: Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy
Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy
raw_author_name: M. Sbaraglia
raw_affiliation_strings: Department of Integrated Diagnostics, Azienda Ospedale-Università Padova, Padova, Italy; Department of Medicine, University of Padova School of Medicine, Padova, Italy
Department of Integrated Diagnostics, Azienda Ospedale-Università Padova; Via A.Gabelli, 61 -35128 Padova, Italy; Department of Medicine, University of Padova School of Medicine, Via A.Gabelli, 61 -35128, Padova, Italy
raw_author_name: L. Righi
raw_affiliation_strings: Department of Oncology, University of Torino, Orbassano, Torino, Italy; AOU San Luigi Gonzaga, Orbassano, Torino, Italy
Department of Oncology, University of Torino; Regione Gonzole 10 - 10043 Orbassano (TO), Italy; AOU San Luigi Gonzaga; Regione Gonzole 10 - 10043 Orbassano (TO), Italy
raw_author_name: M. Rabino
raw_affiliation_strings: Department of Oncology, University of Torino, Orbassano, Torino, Italy; AOU San Luigi Gonzaga, Orbassano, Torino, Italy
Department of Oncology, University of Torino; Regione Gonzole 10 - 10043 Orbassano (TO), Italy; AOU San Luigi Gonzaga; Regione Gonzole 10 - 10043 Orbassano (TO), Italy
raw_author_name: F. Tolomeo
raw_affiliation_strings: Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy
Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy
raw_author_name: S. Aliberti
raw_affiliation_strings: Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy
Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy
raw_author_name: D. Sangiolo
raw_affiliation_strings: Department of Oncology, University of Torino, Orbassano, Torino, Italy; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy
Department of Oncology, University of Torino; Regione Gonzole 10 - 10043 Orbassano (TO), Italy; Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy
raw_author_name: A.P. Dei Tos
raw_affiliation_strings: Department of Integrated Diagnostics, Azienda Ospedale-Università Padova, Padova, Italy; Department of Medicine, University of Padova School of Medicine, Padova, Italy
Department of Integrated Diagnostics, Azienda Ospedale-Università Padova; Via A.Gabelli, 61 -35128 Padova, Italy; Department of Medicine, University of Padova School of Medicine, Via A.Gabelli, 61 -35128, Padova, Italy
raw_author_name: S. Stacchiotti
raw_affiliation_strings: Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori; Via G Venezian 1 - 20133 Milano, Italy
raw_author_name: G. Grignani
raw_affiliation_strings: Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy. Electronic address: giovanni.grignani@ircc.it
Candiolo Cancer Institute, FPO - IRCCS; Strada Provinciale 142, Km 3.95 - 10060 Candiolo (TO), Italy. Electronic address: giovanni.grignani@ircc.it