Colorectal cancer organoids drive hypoxia, TGF-β, and patient-specific diversification of NK cell activation programs
Year: 2025
Type: article
Language: en
Topic: Immune Cell Function and Interaction
Authors and affiliations:
raw_author_name: Andreas von Kries
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Irene Garcés-Lázaro
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Bianca M Balzasch
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Carsten Sticht
raw_affiliation_strings: NGS core facility, Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Indra A Shaltiel
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Kim E Boonekamp
raw_affiliation_strings: Division Signaling and Functional Genomics, DKFZ, Heidelberg, Germany
Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
raw_author_name: Annika Sams
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Alessia Triassi
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Tomáš Hofman
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Elke Burgermeister
raw_affiliation_strings: Department of Medicine II, Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Johannes Betge
raw_affiliation_strings: DKFZ-Hector Cancer Institute at the University Medical Center, DKFZ, Heidelberg, Germany
Department of Medicine II, Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
Junior Clinical Cooperation Unit Translational Gastrointestinal Oncology and Preclinical Models, DKFZ, Heidelberg, Germany
Mannheim Cancer Center (MCC), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Matthias Ebert
raw_affiliation_strings: DKFZ-Hector Cancer Institute at the University Medical Center, DKFZ, Heidelberg, Germany
Department of Medicine II, Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
Mannheim Cancer Center (MCC), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
Molecular Medicine Partnership Unit, EMBL, Heidelberg, Germany
raw_author_name: Michael Boutros
raw_affiliation_strings: Division Signaling and Functional Genomics, DKFZ, Heidelberg, Germany
Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
raw_author_name: Laura Helming
raw_affiliation_strings: EMD Serono Research and Development Institute, Billerica, Massachusetts, USA
raw_author_name: Ana Stojanovic
raw_affiliation_strings: Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
raw_author_name: Adelheid Cerwenka
raw_affiliation_strings: DKFZ-Hector Cancer Institute at the University Medical Center, DKFZ, Heidelberg, Germany
Mannheim Institute for Innate Immunoscience (MI3), Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Mannheim, Germany
Universitätsmedizin Mannheim Zentrum European Center for Angioscience, Mannheim, Germany