Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
Year: 2025
Type: article
Language: en
Topic: Biochemical and Molecular Research
Authors and affiliations:
raw_author_name: Amy E. Stewart
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Derek K. Zachman
raw_affiliation_strings: Department of Pediatrics, Division of Hematology-Oncology, Duke University, Durham, NC, USA
Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Pol Castellano-Escuder
raw_affiliation_strings: Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Lois M. Kelly
raw_affiliation_strings: INSERM U1342, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France
raw_author_name: Ben Zolyomi
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Michael D. I. Aiduk
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Christopher D. Delaney
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Ian C. Lock
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Claudie Bosc
raw_affiliation_strings: Departments of Medicine and Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
raw_author_name: John Bradley
raw_affiliation_strings: Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Shane T. Killarney
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
raw_author_name: J. Darren Stuart
raw_affiliation_strings: Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Paul A. Grimsrud
raw_affiliation_strings: Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University, Durham, NC, USA
Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Olga R. Ilkayeva
raw_affiliation_strings: Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University, Durham, NC, USA
Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Christopher B. Newgard
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Navdeep S. Chandel
raw_affiliation_strings: Departments of Medicine and Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
raw_author_name: Alexandre Puissant
raw_affiliation_strings: INSERM U1342, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France. alexandre.puissant@inserm.fr
INSERM U1342, IRSL, Saint-Louis Hospital, Paris Cité University, Paris, France
raw_author_name: Kris C. Wood
raw_affiliation_strings: Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA. kris.wood@duke.edu
Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA
raw_author_name: Matthew D. Hirschey
raw_affiliation_strings: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore. matthew.hirschey@duke.edu
Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University, Durham, NC, USA. matthew.hirschey@duke.edu
Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA. matthew.hirschey@duke.edu
Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA. matthew.hirschey@duke.edu
Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore