A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
Year: 2025
Type: article
Language: en
Topic: CAR-T cell therapy research
Authors and affiliations:
raw_author_name: Michael Rade
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
raw_author_name: David Fandrei
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Markus Kreuz
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
raw_author_name: Sabine Seiffert
raw_affiliation_strings: Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany
raw_author_name: Anja Grahnert
raw_affiliation_strings: Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany
raw_author_name: Maik Friedrich
raw_affiliation_strings: Broad Institute of MIT and Harvard, Cambridge, MA, USA
Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany
raw_author_name: Thomas Wiemers
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Patrick Born
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Luise Fischer
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Heike Weidner
raw_affiliation_strings: Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
raw_author_name: Lorenz C. Hofbauer
raw_affiliation_strings: Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
raw_author_name: Ronny Baber
raw_affiliation_strings: Institute for Laboratory Medicine Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany; Leipzig Medical Biobank, University Leipzig, Leipzig, Germany
raw_author_name: Song Yau Wang
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Enrica Bach
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Sandra Hoffmann
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Jonathan Scolnick
raw_affiliation_strings: Singleron Biotechnologies, Singapore, Singapore
raw_author_name: Mirco Friedrich
raw_affiliation_strings: Broad Institute of MIT and Harvard, Cambridge, MA, USA
Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany
raw_author_name: Farid Keramati
raw_affiliation_strings: Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
raw_author_name: Peter Brazda
raw_affiliation_strings: Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
raw_author_name: Zsolt Sebestyen
raw_affiliation_strings: Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
raw_author_name: Jürgen Kuball
raw_affiliation_strings: Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
raw_author_name: Miriam Alb
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany
raw_author_name: Lukas Scheller
raw_affiliation_strings: Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany
raw_author_name: Michael Hudecek
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany
raw_author_name: Hermann Einsele
raw_affiliation_strings: Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg, Würzburg, Germany
raw_author_name: Klaus H. Metzeler
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Marco Herling
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Carmen Diana Herling
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Madlen Jentzsch
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Georg-Nikolaus Franke
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Andreas Boldt
raw_affiliation_strings: Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany
raw_author_name: Ulrike Köhl
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Uwe Platzbecker
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
raw_author_name: Vladan Vucinic
raw_affiliation_strings: Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany
raw_author_name: Kristin Reiche
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden, Leipzig, Germany
raw_author_name: Maximilian Merz
raw_affiliation_strings: Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Department of Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany; Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; Myeloma and Cellular Therapy Services, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: merzm@mskcc.org