Tetrahydroquinoline/4,5-dihydroisoxazoline derivatives counteract multidrug resistance in cancer cells by inhibiting P-glycoprotein (ABCB1)-mediated transport
Year: 2025
Type: article
Language: en
Topic: Drug Transport and Resistance Mechanisms
Authors and affiliations:
raw_author_name: Marina Hembecker
raw_affiliation_strings: Graduate Program in Cell and Molecular Biology, Federal University of Parana, Curitiba, PR, Brazil
Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba 80210-170, PR, Brazil
raw_author_name: Diogo Henrique Kita
raw_affiliation_strings: Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba 80210-170, PR, Brazil; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4256, USA
Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba 80210-170, PR, Brazil; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institutes of Health, Bethesda, MD 20892-4256, USA
raw_author_name: Azam Rashidian
raw_affiliation_strings: Institut für Medizinische Mikrobiologie und Hygiene. Center for Infection Research (DZIF) Partner-site Tübingen, DE 72076, Tübingen, Germany
German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany
raw_author_name: Luis C. Vesga
raw_affiliation_strings: Grupo de Investigación en Bioquímica y Microbiologia (GIBIM), Escuela de Química, Universidad Industrial de Santander, Bucaramanga, Colombia
raw_author_name: Bruna Estelita Ruginsk
raw_affiliation_strings: Graduate Program in Cell and Molecular Biology, Federal University of Parana, Curitiba, PR, Brazil
Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba 80210-170, PR, Brazil
raw_author_name: Arnold R. Romero Bohórquez
raw_affiliation_strings: Grupo de Investigación em Compuestos Orgánicos de Interés Medicinal (CODEIM), Universidad Industrial de Santander, Bucaramanga, Colombia
raw_author_name: Stelia Carolina Mendez-Sanchez
raw_affiliation_strings: Grupo de Investigación en Bioquímica y Microbiologia (GIBIM), Escuela de Química, Universidad Industrial de Santander, Bucaramanga, Colombia; Grupo de Investigación em Compuestos Orgánicos de Interés Medicinal (CODEIM), Universidad Industrial de Santander, Bucaramanga, Colombia
raw_author_name: Vinicius Goncalves Maltarollo
raw_affiliation_strings: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil
raw_author_name: Fabiane Gomes de Moraes Rego
raw_affiliation_strings: Graduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba 80210-170, PR, Brazil
raw_author_name: Geraldo Picheth
raw_affiliation_strings: Graduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba 80210-170, PR, Brazil
raw_author_name: Antti Poso
raw_affiliation_strings: School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland
raw_author_name: Katalin Goda
raw_affiliation_strings: Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egytem tér 1, Debracen H-4032, Hungary
raw_author_name: Suresh V. Ambudkar
raw_affiliation_strings: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4256, USA
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institutes of Health, Bethesda, MD 20892-4256, USA
raw_author_name: Vivian Rotuno Moure
raw_affiliation_strings: Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba 80210-170, PR, Brazil
raw_author_name: Thales Kronenberger
raw_affiliation_strings: Institut für Medizinische Mikrobiologie und Hygiene. Center for Infection Research (DZIF) Partner-site Tübingen, DE 72076, Tübingen, Germany; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: thales.kronenberger@uni-tuebingen.de
German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: thales.kronenberger@uni-tuebingen.de
raw_author_name: Glaucio Valdameri
raw_affiliation_strings: Graduate Program in Cell and Molecular Biology, Federal University of Parana, Curitiba, PR, Brazil; Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba 80210-170, PR, Brazil. Electronic address: gvaldameri@ufpr.br
Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba 80210-170, PR, Brazil. Electronic address: gvaldameri@ufpr.br