Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression
Year: 2025
Type: article
Language: en
Topic: interferon and immune responses
Authors and affiliations:
raw_author_name: Lingling Gao
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Jie Jiang
raw_affiliation_strings: Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
School of Medicine, South China University of Technology, Guangzhou, China
raw_author_name: Linlin Zhu
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Zhi Xie
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Yu Chen
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
School of Medicine, South China University of Technology, Guangzhou, China
raw_author_name: Zhiyi Lv
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Yuqing Chen
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
School of Medicine, South China University of Technology, Guangzhou, China
raw_author_name: Wenbin Zhou
raw_affiliation_strings: Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
School of Medicine, South China University of Technology, Guangzhou, China
raw_author_name: Ji Chen
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Yumin Zhong
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Li Zhang
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Penghui Zeng
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Xiaodan Huang
raw_affiliation_strings: Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
School of Medicine, South China University of Technology, Guangzhou, China
raw_author_name: Wenqing Yan
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Danxia Lu
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Shuilian Zhang
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Weibang Guo
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Dongkun Zhang
raw_affiliation_strings: Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
raw_author_name: Haiyu Zhou
raw_affiliation_strings: Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
raw_author_name: Weineng Feng
raw_affiliation_strings: Department of Head and Neck/Thoracic Medical Oncology, The First People's Hospital of Foshan, Foshan, China
raw_author_name: Binchao Wang
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Zunfu Ke
raw_affiliation_strings: Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangzhou, China
raw_author_name: Xuening Yang
raw_affiliation_strings: Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China. yangxncn@qq.com
Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
raw_author_name: Hongling Liang
raw_affiliation_strings: Department of Breast Oncology Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 78 Hengzhigang Road, Guangzhou, 510095, China. lianghonglingu2@163.com
Department of Breast Oncology Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 78 Hengzhigang Road, Guangzhou, 510095, China
raw_author_name: Xuchao Zhang
raw_affiliation_strings: Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China. zhxuchao3000@126.com
School of Medicine, South China University of Technology, Guangzhou, China. zhxuchao3000@126.com
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Rd., Guangzhou, 510080, China
School of Medicine, South China University of Technology, Guangzhou, China