Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice
Year: 2025
Type: article
Language: en
Topic: Tryptophan and brain disorders
Authors and affiliations:
raw_author_name: Sisi Wang
raw_affiliation_strings: State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
raw_author_name: Xiaoyu Zhou
raw_affiliation_strings: State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
raw_author_name: Mengdan Li
raw_affiliation_strings: School of Pharmacy Henan University  Kaifeng 475004 China
State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
School of Pharmacy, Henan University, Kaifeng, 475004 China
raw_author_name: Chao Zhang
raw_affiliation_strings: State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
raw_author_name: Haiyan Xu
raw_affiliation_strings: State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
raw_author_name: Jingyi He
raw_affiliation_strings: State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
raw_author_name: Li Zhan
raw_affiliation_strings: State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
raw_author_name: Yueling Gu
raw_affiliation_strings: State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
raw_author_name: Hao Gu
raw_affiliation_strings: State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
raw_author_name: Tianyu Tu
raw_affiliation_strings: State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
raw_author_name: Hanfang Liu
raw_affiliation_strings: State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
raw_author_name: Taotao Lu
raw_affiliation_strings: State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
raw_author_name: Yueming Zheng
raw_affiliation_strings: State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
raw_author_name: Jian Li
raw_affiliation_strings: Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical Sciences Hainan University  Haikou 570228 China
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization Ministry of Education School of Pharmacy Shihezi University  Shihezi 832003 China
State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, 832003 China
raw_author_name: Zhaobing Gao
raw_affiliation_strings: School of Pharmacy Henan University  Kaifeng 475004 China
State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China
Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan 528437 China
School of Pharmacy, Henan University, Kaifeng, 475004 China
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528437 China
raw_author_name: Yixiang Xu
raw_affiliation_strings: State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology  Shanghai 200237 China
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China