Spontaneous generation of diverse recombinant prion strains: sulfated glycan cofactors facilitate strain emergence but do not determine specific strain properties
Year: 2025
Type: article
Language: en
Topic: Prion Diseases and Protein Misfolding
Authors and affiliations:
raw_author_name: Nuria L. Lorenzo
raw_affiliation_strings: CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain
raw_author_name: Hasier Eraña
raw_affiliation_strings: ATLAS Molecular Pharma S. L, Derio, Spain
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain
Prion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain
Prion Research Lab, CIC BioGUNE,  Basque Research and Technology Alliance (BRTA), Derio, Spain
raw_author_name: Enric Vidal
raw_affiliation_strings: IRTA. Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona (UAB), Campus, Bellaterra, Catalonia, Spain
Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain
Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA),  Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain
raw_author_name: Jorge M. Charco
raw_affiliation_strings: ATLAS Molecular Pharma S. L, Derio, Spain
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain
Prion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain
Prion Research Lab, CIC BioGUNE,  Basque Research and Technology Alliance (BRTA), Derio, Spain
raw_author_name: Lucía Parga
raw_affiliation_strings: CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain
raw_author_name: Carlos M. Díaz-Domínguez
raw_affiliation_strings: Prion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain
Prion Research Lab, CIC BioGUNE,  Basque Research and Technology Alliance (BRTA), Derio, Spain
raw_author_name: Sonia Veiga
raw_affiliation_strings: CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain
raw_author_name: Susana Bravo
raw_affiliation_strings: Proteomics Unit, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, Spain
raw_author_name: Samanta Giler
raw_affiliation_strings: IRTA. Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona (UAB), Campus, Bellaterra, Catalonia, Spain
Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain
Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA),  Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain
raw_author_name: Mariví Geijo
raw_affiliation_strings: Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development , Basque Research and Technology Alliance (BRTA), Derio, Spain
raw_author_name: Jesús R. Requena
raw_affiliation_strings: CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain. jesus.requena@usc.es
CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain
raw_author_name: Joaquín Castilla
raw_affiliation_strings: Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain. jcastilla@cicbiogune.es
IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. jcastilla@cicbiogune.es
Prion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain. jcastilla@cicbiogune.es
IKERBASQUE, Basque Foundation for Science, Bilbao, Spain