Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias
Year: 2025
Type: article
Language: en
Topic: Cytokine Signaling Pathways and Interactions
Authors and affiliations:
raw_author_name: Husheng Mei
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Wuqiang Wen
raw_affiliation_strings: Department of Radiation and Medical Oncology Medical Research Institute Frontier Science Center of Immunology and Metabolism Hubei Key Laboratory of Tumor Biological Behavior Zhongnan Hospital of Wuhan University Wuhan University  Wuhan 430071 P. R. China
Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071 P. R. China
raw_author_name: Wenjun Zhang
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Shujing Zhang
raw_affiliation_strings: Institute of Translational Medicine Medical College Yangzhou University  Yangzhou 225001 P. R. China
Key Lab of Chemical Biology School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 P. R. China
Key Lab of Chemical Biology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012 P. R. China
raw_author_name: Ting Sun
raw_affiliation_strings: State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Tianjin &amp; CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300020 P. R. China
State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Tianjin &amp; CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin 300020 P. R. China
raw_author_name: Guiming Li
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Jing Zhang
raw_affiliation_strings: State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Tianjin &amp; CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300020 P. R. China
State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Tianjin &amp; CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin 300020 P. R. China
raw_author_name: Shuang Qi
raw_affiliation_strings: Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical Technology Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei 230031 P. R. China
Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031 P. R. China
raw_author_name: Jie Zhou
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Bing Li
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Yunshuo Zhao
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Xiaotong Chen
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Bowen Li
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Yiying Xue
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Wang Lu
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Lingang Laboratory  Shanghai 200031 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Yanli Sun
raw_affiliation_strings: Lingang Laboratory  Shanghai 200031 P. R. China
Lingang Laboratory, Shanghai, 200031 P. R. China
raw_author_name: Jingyao Wang
raw_affiliation_strings: Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences  Shanghai 201210 P. R. China
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210 P. R. China
raw_author_name: Hengyue Shan
raw_affiliation_strings: Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences  Shanghai 201210 P. R. China
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210 P. R. China
raw_author_name: Shengzhe Zhang
raw_affiliation_strings: Institute of Translational Medicine Medical College Yangzhou University  Yangzhou 225001 P. R. China
Key Lab of Chemical Biology School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 P. R. China
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225001 P. R. China
raw_author_name: Yushan Huang
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Yisa Chen
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Wenchao Wang
raw_affiliation_strings: Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical Technology Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei 230031 P. R. China
Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031 P. R. China
raw_author_name: Qingsong Liu
raw_affiliation_strings: Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical Technology Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei 230031 P. R. China
Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031 P. R. China
raw_author_name: Wenchao Lu
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Lingang Laboratory  Shanghai 200031 P. R. China
Lingang Laboratory, Shanghai, 200031 P. R. China
raw_author_name: Li Tan
raw_affiliation_strings: Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences  Shanghai 201210 P. R. China
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210 P. R. China
raw_author_name: Yi Ding
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Jianfei Fu
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Jun Long
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Lei Zhang
raw_affiliation_strings: State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Tianjin &amp; CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin 300020 P. R. China
State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Tianjin &amp; CAMS Key Laboratory of Gene Therapy for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin 300020 P. R. China
raw_author_name: Baobing Zhao
raw_affiliation_strings: Key Lab of Chemical Biology School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 P. R. China
Key Lab of Chemical Biology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012 P. R. China
raw_author_name: Aibin Liang
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China
raw_author_name: Baishan Jiang
raw_affiliation_strings: Department of Radiation and Medical Oncology Medical Research Institute Frontier Science Center of Immunology and Metabolism Hubei Key Laboratory of Tumor Biological Behavior Zhongnan Hospital of Wuhan University Wuhan University  Wuhan 430071 P. R. China
Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071 P. R. China
raw_author_name: Jing Yang
raw_affiliation_strings: Department of Hematology Tongji Hospital Frontier Science Center for Stem Cell Research Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University  Shanghai 200092 P. R. China
Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 P. R. China