Reduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity
Year: 2025
Type: article
Language: en
Topic: Acute Lymphoblastic Leukemia research
Authors and affiliations:
raw_author_name: Thomas Lefeivre
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
2School of Medicine, University College Dublin, Dublin, Ireland
University College Dublin, Dublin, Ireland
raw_author_name: Theodora-Ioana Grosu
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
2School of Medicine, University College Dublin, Dublin, Ireland
University College Dublin, Dublin, Ireland
raw_author_name: Cosmin Tudose
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
2School of Medicine, University College Dublin, Dublin, Ireland
3Research Ireland Centre for Research Training in Genomics Data Science, Galway, Ireland
University College Dublin, Dublin, Ireland
raw_author_name: Luke Jones
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
2School of Medicine, University College Dublin, Dublin, Ireland
University College Dublin, Dublin, Ireland
raw_author_name: Theresa E. León
raw_affiliation_strings: 4Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom
University College London, London, United Kingdom
raw_author_name: Kieran Wynne
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
University College Dublin, Dublin, Ireland
raw_author_name: Giorgio Oliviero
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
University College Dublin, Dublin, Ireland
raw_author_name: Owen P. Smith
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
2School of Medicine, University College Dublin, Dublin, Ireland
5University of Dublin, Trinity College, Dublin, Ireland
6National Children’s Cancer Service, Children’s Health Ireland at Crumlin, Dublin, Ireland
Trinity College Dublin, Dublin, Ireland
raw_author_name: Amélie Trinquand
raw_affiliation_strings: 6National Children’s Cancer Service, Children’s Health Ireland at Crumlin, Dublin, Ireland
Children's Health Ireland at Crumlin, Dublin, Ireland
raw_author_name: Marc R. Mansour
raw_affiliation_strings: 4Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom
7Division of Developmental Biology and Cancer, Great Ormond Street Institute of Child Health, London, United Kingdom
University College London, London, United Kingdom
raw_author_name: Colm J. Ryan
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
2School of Medicine, University College Dublin, Dublin, Ireland
8Conway Institute, University College Dublin, Dublin, Ireland
University College Dublin, Dublin, Ireland
raw_author_name: Jonathan Bond
raw_affiliation_strings: 1Systems Biology Ireland, University College Dublin, Dublin, Ireland
2School of Medicine, University College Dublin, Dublin, Ireland
6National Children’s Cancer Service, Children’s Health Ireland at Crumlin, Dublin, Ireland
University College Dublin, Dublin, Ireland