Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer
Year: 2025
Type: article
Language: en
Topic: Glioma Diagnosis and Treatment
Authors and affiliations:
raw_author_name: Xuan Chen
raw_affiliation_strings: College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; BGI Research, Chongqing 401329, China; BGI Research, Shenzhen, Guangdong 518083, China
raw_author_name: Ziwei Wang
raw_affiliation_strings: BGI Research, Chongqing 401329, China; BGI Research, Shenzhen, Guangdong 518083, China
raw_author_name: Yan Song
raw_affiliation_strings: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 10029, China
raw_author_name: Yu Su
raw_affiliation_strings: School of Public Health, Capital Medical University, Beijing 100069, China
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 10029, China
raw_author_name: Yahui Zhao
raw_affiliation_strings: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Beijing Neurosurgical Institute, Beijing 100070, China
raw_author_name: Jiankang Li
raw_affiliation_strings: BGI Research, Chongqing 401329, China; BGI Research, Shenzhen, Guangdong 518083, China; Computer Science Department, City University of Hong Kong, Kowloon, Hong Kong, China; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China
raw_author_name: Wei Wang
raw_affiliation_strings: Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
raw_author_name: Jiao Zhang
raw_affiliation_strings: Cancer and Hematology Center, Texas Children's Hospital, Houston, TX 77002, USA; Department of Pediatrics-Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, TX 77002, USA; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; The Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1, Canada
raw_author_name: Craig Daniels
raw_affiliation_strings: Cancer and Hematology Center, Texas Children's Hospital, Houston, TX 77002, USA; Department of Pediatrics-Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, TX 77002, USA; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; The Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1, Canada
raw_author_name: Xiaochong Wu
raw_affiliation_strings: Cancer and Hematology Center, Texas Children's Hospital, Houston, TX 77002, USA; Department of Pediatrics-Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, TX 77002, USA; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; The Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1, Canada
raw_author_name: Olivier Saulnier
raw_affiliation_strings: Genomics and Development of Childhood Cancers Lab, Inserm U1330, Institut Curie, PSL University, SiREDO Oncology Center, Paris, France
raw_author_name: Yanan Wang
raw_affiliation_strings: State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
raw_author_name: Fei Liu
raw_affiliation_strings: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
raw_author_name: Kaiwen Deng
raw_affiliation_strings: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
raw_author_name: Dongming Han
raw_affiliation_strings: College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; BGI Research, Chongqing 401329, China; BGI Research, Shenzhen, Guangdong 518083, China
raw_author_name: Zijia Liu
raw_affiliation_strings: College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; BGI Research, Chongqing 401329, China; BGI Research, Shenzhen, Guangdong 518083, China
raw_author_name: Meiyu Li
raw_affiliation_strings: College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; BGI Research, Chongqing 401329, China; BGI Research, Shenzhen, Guangdong 518083, China
raw_author_name: Liam D. Hendrikse
raw_affiliation_strings: The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; The Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1, Canada
raw_author_name: Alexandra Rasnitsyn
raw_affiliation_strings: The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; The Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1, Canada
raw_author_name: Evan Y. Wang
raw_affiliation_strings: The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; The Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1, Canada
raw_author_name: Dongyang Wang
raw_affiliation_strings: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
raw_author_name: Zhaoyang Feng
raw_affiliation_strings: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
raw_author_name: Yanong Li
raw_affiliation_strings: Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
raw_author_name: Zitong Zhao
raw_affiliation_strings: State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
raw_author_name: Hongyu Yuan
raw_affiliation_strings: Institute of Basic Medicine, School of Medicine, Tsinghua University, Beijing 100084, China
raw_author_name: Youliang Sun
raw_affiliation_strings: Institute of Basic Medicine, School of Medicine, Tsinghua University, Beijing 100084, China
raw_author_name: Yifei Jiang
raw_affiliation_strings: University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
raw_author_name: Yanfeng Shi
raw_affiliation_strings: China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
raw_author_name: Tao Yang
raw_affiliation_strings: China National GeneBank, BGI-Research, Shenzhen, Guangdong 518083, China
raw_author_name: Xueling Qi
raw_affiliation_strings: Department of Neuro-Pathology, Sanbo Brain Hospital Capital Medical University, Beijing 100093, China
raw_author_name: Yong Hou
raw_affiliation_strings: College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; BGI Research, Shenzhen, Guangdong 518083, China
raw_author_name: Chunde Li
raw_affiliation_strings: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
raw_author_name: Yong-qiang Liu
raw_affiliation_strings: Research Center of Chinese Herbal Resource Science and Engineering, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
raw_author_name: Yu Tian
raw_affiliation_strings: School of Public Health, Capital Medical University, Beijing 100069, China; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Shuaicheng Li
raw_affiliation_strings: Computer Science Department, City University of Hong Kong, Kowloon, Hong Kong, China
raw_author_name: Xiaoguang Qiu
raw_affiliation_strings: Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1, Canada
raw_author_name: Michael D. Taylor
raw_affiliation_strings: Cancer and Hematology Center, Texas Children's Hospital, Houston, TX 77002, USA; Department of Pediatrics-Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, TX 77002, USA; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1, Canada; The Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1, Canada
raw_author_name: Guo Liang Li
raw_affiliation_strings: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 10029, China. Electronic address: glli@buct.edu.cn
raw_author_name: Tao Jiang
raw_affiliation_strings: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Beijing Neurosurgical Institute, Beijing 100070, China. Electronic address: zacharytaojiang@163.com
raw_author_name: Hailong Liu
raw_affiliation_strings: China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Beijing Neurosurgical Institute, Beijing 100070, China; Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Chinese Institute for Medical Research, Beijing 100069, China. Electronic address: liuhailonger@163.com