The use of multiple liquid chromatography methods augmented by phosphorus-31 nuclear magnetic resonance to characterize the diastereomer composition in synthetic oligonucleotides
Year: 2025
Type: article
Language: en
Topic: DNA and Nucleic Acid Chemistry
Authors and affiliations:
raw_author_name: Mohsin Ali
raw_affiliation_strings: Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore, MD, 21201, USA; Faculty of Pharmaceutical Sciences, GC University Faisalabad, Punjab, Pakistan
raw_author_name: Akanksha Manghrani
raw_affiliation_strings: Institute for Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, 9600 Gudelsky Drive, Rockville, MD 20850, United States
raw_author_name: Mirandia Szramowski
raw_affiliation_strings: Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore, MD, 21201, USA
raw_author_name: Ahmed M. Abdel-Megied
raw_affiliation_strings: Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore, MD, 21201, USA; Department of Pharmaceutical Sciences, Notre Dame of Maryland University, School of Pharmacy, Baltimore, MD 21210, USA
raw_author_name: Likan Liang
raw_affiliation_strings: Division of Product Quality Assessment X, Office of Product Quality Assessment II, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, United States
raw_author_name: Nils F. Aberg
raw_affiliation_strings: Division of Product Quality Assessment X, Office of Product Quality Assessment II, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, United States
raw_author_name: Kui Yang
raw_affiliation_strings: Division of Pharmaceutical Quality Research II, Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, St Louis, MO 63110, United States
raw_author_name: Kang Chen
raw_affiliation_strings: Division of Pharmaceutical Quality Research II, Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, United States
raw_author_name: Yan Wang
raw_affiliation_strings: Division of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, United States
raw_author_name: Deyi Zhang
raw_affiliation_strings: Division of Therapeutic Performance I, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, United States
raw_author_name: Steven Fletcher
raw_affiliation_strings: Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore, MD, 21201, USA
raw_author_name: Robert G. Brinson
raw_affiliation_strings: Institute for Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, 9600 Gudelsky Drive, Rockville, MD 20850, United States
raw_author_name: Jace W. Jones
raw_affiliation_strings: Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore, MD, 21201, USA. Electronic address: jjones@rx.umaryland.edu