Tempered signal strength via low-dose MEK inhibition optimizes therapeutic performance of engineered T cells
Year: 2025
Type: article
Language: en
Topic: CAR-T cell therapy research
Authors and affiliations:
raw_author_name: Franziska Füchsl
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Antonia Schwanzer
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Melanie Faber
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Leonie Rieger
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Gabriela Zuleger
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Priska Auf der Maur
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Emmanuel Cruz
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Sarah Braun
raw_affiliation_strings: Institute of Medical Microbiology Immunology and Hygiene, Technical University of Munich, Munich, Germany
raw_author_name: Rupert Öllinger
raw_affiliation_strings: Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany
raw_author_name: Dirk H Busch
raw_affiliation_strings: German Center for Infection Research, Munich Site, Munich, Germany
Institute of Medical Microbiology Immunology and Hygiene, Technical University of Munich, Munich, Germany
raw_author_name: Florian Bassermann
raw_affiliation_strings: Bavarian Cancer Research Center, Erlangen, Germany
Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
German Cancer Consortium (DKTK), partner-site Munich, German Cancer Research Center (DKFZ), Heidelberg, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany
raw_author_name: Angela M Krackhardt
raw_affiliation_strings: Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany
German Cancer Consortium (DKTK), partner-site Munich, German Cancer Research Center (DKFZ), Heidelberg, Germany
School of Medicine and Health, III Medical Department, TUM University Hospital, Technical University of Munich, Munich, Germany