Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus
Year: 2025
Type: preprint
Language: en
Topic: Hearing, Cochlea, Tinnitus, Genetics
Authors and affiliations:
raw_author_name: Nick M.A. Shubert
raw_affiliation_strings: Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands
raw_author_name: Shuyang Yao
raw_affiliation_strings: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
raw_author_name: Maryam Kazemi Naeini
raw_affiliation_strings: Department of Twin Research and Genetic Epidemiology, School of Life Course and Population Sciences, King's College London, London, UK
raw_author_name: Natalia Trpchevska
raw_affiliation_strings: Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden
Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm,
raw_author_name: Charles Bishop
raw_affiliation_strings: Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA
raw_author_name: Argyro Bizaki-Vallaskangas
raw_affiliation_strings: Pirkanmaan hyvinvointialue, Department of Ear and Oral Diseases, Tampere, Finland
Tampere University, Faculty of Medicine and Health Technology, Department of Otolaryngology, Tampere, Finland
raw_author_name: Linda Broer
raw_affiliation_strings: Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
raw_author_name: Fabio Castellana
raw_affiliation_strings: Unit of Epidemiology and Statistics, Local Health Authority of Taranto, Taranto, Italy
raw_author_name: Kaare Christensen
raw_affiliation_strings: Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark
Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark
The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark
raw_author_name: Jacob v. B. Hjelmborg
raw_affiliation_strings: Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark
raw_author_name: Maria Pina Concas
raw_affiliation_strings: Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy
Institute for Maternal and Child Health IRCCS, Burlo Garofolo, 34127 Trieste, Italy
raw_author_name: Aurora Santin
raw_affiliation_strings: Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy
Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy
Institute for Maternal and Child Health IRCCS, Burlo Garofolo, 34127 Trieste, Italy
raw_author_name: Giorgia Girotto
raw_affiliation_strings: Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy
Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy
Institute for Maternal and Child Health IRCCS, Burlo Garofolo, 34127 Trieste, Italy
raw_author_name: Giuseppe Giovanni Nardone
raw_affiliation_strings: Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy
raw_author_name: Licia Iacoviello
raw_affiliation_strings: Department of Epidemiology and Prevention, I.R.C.C.S. Neuromed, Pozzilli, Italy
Department of Medicine and Surgery, LUM University, Casamassima, Italy
raw_author_name: Jonas Mengel-From
raw_affiliation_strings: Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark
The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark
raw_author_name: Scott Gallagher
raw_affiliation_strings: Decibel Therapeutics Inc
raw_author_name: Alexander Gudjonsson
raw_affiliation_strings: Icelandic Heart Association, 201 Kopavogur, Iceland
raw_author_name: Vilmundur Gudnason
raw_affiliation_strings: Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
Icelandic Heart Association, 201 Kopavogur, Iceland
raw_author_name: Nancy L. Heard-Costa
raw_affiliation_strings: Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA
Framingham Heart Study, Framingham, MA 01702, USA
raw_author_name: Sudha Seshadri
raw_affiliation_strings: Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA
Framingham Heart Study, Framingham, MA 01702, USA
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases and Department of Population Health Sciences, University of Texas Health Sciences Center, San Antonio, TX 78229, USA
raw_author_name: Howard J. Hoffman
raw_affiliation_strings: Epidemiology, Statistics, and Population Sciences, National Institute on Deafness and Other Communications Disorders (NIDCD), NIH, Bethesda, MD 20892, USA
raw_author_name: Chuan-Ming Li
raw_affiliation_strings: Epidemiology, Statistics, and Population Sciences, National Institute on Deafness and Other Communications Disorders (NIDCD), NIH, Bethesda, MD 20892, USA
raw_author_name: Jaakko Kaprio
raw_affiliation_strings: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland
raw_author_name: Joel Rämö
raw_affiliation_strings: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland
raw_author_name: Elmo Saarentaus
raw_affiliation_strings: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland
raw_author_name: Johannes Kettunen
raw_affiliation_strings: Biocenter Oulu, University of Oulu, 90220 Oulu, Finland
Finnish Institute for Health and Welfare, 00271 Helsinki, Finland
Systems medicine, Research unit of Population Health, University of Oulu, 90220 Oulu, Finland
Systems medicine, Research unit of Population Health, University of Oulu, 902 Oulu, Finland
raw_author_name: Kristi Krebs
raw_affiliation_strings: Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
raw_author_name: Anna K. Kähler
raw_affiliation_strings: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
raw_author_name: Lenore J. Launer
raw_affiliation_strings: Laboratory of Epidemiology and Population Sciences, Intramural Research Program National Institute on Aging, Bethesda, MD 20892, USA
raw_author_name: Hampton Leonard
raw_affiliation_strings: Center for Alzheimer's and Related Dementias, Bethesda, MD 20892, USA
Data Tecnica, Washington DC, 20037, USA
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
raw_author_name: Mike A. Nalls
raw_affiliation_strings: Center for Alzheimer's and Related Dementias, Bethesda, MD 20892, USA
Data Tecnica, Washington DC, 20037, USA
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
raw_author_name: Patrik K.E. Magnusson
raw_affiliation_strings: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
raw_author_name: Joyce van Meurs
raw_affiliation_strings: Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
raw_author_name: Lili Milani
raw_affiliation_strings: Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
raw_author_name: Antti Mäkitie
raw_affiliation_strings: Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 HUS, Helsinki, Finland
raw_author_name: Berthe C. Oosterloo
raw_affiliation_strings: Department of Otorhinolaryngology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
raw_author_name: Marianne Nygaard
raw_affiliation_strings: Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark
The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark
raw_author_name: Teemu Palviainen
raw_affiliation_strings: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland
raw_author_name: Sheila Pratt
raw_affiliation_strings: Department of Communication Science & Disorders, University of Pittsburgh, Pittsburgh, Pa 15260, USA
raw_author_name: Nicola Quaranta
raw_affiliation_strings: Otolaryngology Unit, Department of Translational Biomedicine and Neuroscience (DiBrain), University of Bari, Policlinico di Bari, Italy
raw_author_name: Rodolfo Sardone
raw_affiliation_strings: Unit of Epidemiology and Statistics, Local Health Authority of Taranto, Taranto, Italy
raw_author_name: Claudia L. Satizabal
raw_affiliation_strings: Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA
Framingham Heart Study, Framingham, MA 01702, USA
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases and Department of Population Health Sciences, University of Texas Health Sciences Center, San Antonio, TX 78229, USA
raw_author_name: John M. Schweinfurth
raw_affiliation_strings: Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA
raw_author_name: Eric Shiroma
raw_affiliation_strings: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD 21224, USA
raw_author_name: Eleanor Simonsick
raw_affiliation_strings: Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA
raw_author_name: Lifelines Cohort Study
raw_affiliation_strings: Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA
raw_author_name: Christopher Spankovich
raw_affiliation_strings: Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
raw_author_name: Patrick F. Sullivan
raw_affiliation_strings: Department of Genetics, University of North Carolina, Chapel Hill, NC 27516, USA
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Department of Otorhinolaryngology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
raw_author_name: Andre Goedegebure
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raw_author_name: Andries Paul Nagtegaal
raw_affiliation_strings: Department of Otorhinolaryngology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands
raw_author_name: Sonja J. Pyott
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Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands
Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm,
raw_author_name: Christopher R. Cederroth
raw_affiliation_strings: Department of Otolaryngology, Head & Neck Surgery, University of Tübingen Medical Center, 72076 Tübingen, Germany
Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden
Department of Twin Research and Genetic Epidemiology, School of Life Course and Population Sciences, King's College London, London, UK
raw_author_name: Maxim B. Freidin
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raw_author_name: Frances MK Williams
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