Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment
Year: 2025
Type: article
Language: en
Topic: RNA modifications and cancer
Authors and affiliations:
raw_author_name: Karthika Annamalai
raw_affiliation_strings: DZHK (German Centre for Cardiovascular Research) Partner Site Munich Heart Alliance, Munich, Germany
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
Institute for Cardiovascular Prevention (IPEK), University Hospital, LMU Munich, Munich, Germany
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München (Helmholtz Munich), Munich, Germany
raw_author_name: Soniya Dilliker
raw_affiliation_strings: DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Eric Buchholz
raw_affiliation_strings: Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Ricardo Castro-Hernández
raw_affiliation_strings: Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
raw_author_name: Nikita Panyam
raw_affiliation_strings: DZHK (German Centre for Cardiovascular Research) Partner Site Munich Heart Alliance, Munich, Germany
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Alessa Pommeranz
raw_affiliation_strings: Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Pascal Wiederhake
raw_affiliation_strings: Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Nelly Wery von Limont
raw_affiliation_strings: Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Nina Hempel
raw_affiliation_strings: Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
raw_author_name: Verena Ebner
raw_affiliation_strings: Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Surabhi Swarnkar
raw_affiliation_strings: DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Belal A. Mohamed
raw_affiliation_strings: DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Katrin Streckfuss-Bömeke
raw_affiliation_strings: Clinic for Cardiology and Pneumology, University Hospital Göttingen, Robert-Koch-Strasse 40, Göttingen, 37075, Germany
DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany
Institute for Pharmacology and Toxicology of the University of Würzburg, Würzburg, Germany
Medical Clinic I, Cardiology and Angiology, Justus Liebig University, Giessen, Germany
raw_author_name: Sabine Steffens
raw_affiliation_strings: DZHK (German Centre for Cardiovascular Research) Partner Site Munich Heart Alliance, Munich, Germany
Institute for Cardiovascular Prevention (IPEK), University Hospital, LMU Munich, Munich, Germany
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München (Helmholtz Munich), Munich, Germany
raw_author_name: Stephan Herzig
raw_affiliation_strings: DZHK (German Centre for Cardiovascular Research) Partner Site Munich Heart Alliance, Munich, Germany
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München (Helmholtz Munich), Munich, Germany
raw_author_name: Antje Ebert
raw_affiliation_strings: Cluster of Excellence MBExC, University of Göttingen & University Medical Center Göttingen, Göttingen, Germany
DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
raw_author_name: Andre Fischer
raw_affiliation_strings: Cluster of Excellence MBExC, University of Göttingen & University Medical Center Göttingen, Göttingen, Germany
DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany
Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
raw_author_name: Karl Toischer
raw_affiliation_strings: Clinic for Cardiology and Pneumology, University Hospital Göttingen, Robert-Koch-Strasse 40, Göttingen, 37075, Germany. ktoischer@med.uni-goettingen.de
Cluster of Excellence MBExC, University of Göttingen & University Medical Center Göttingen, Göttingen, Germany. ktoischer@med.uni-goettingen.de
DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany. ktoischer@med.uni-goettingen.de
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany. ktoischer@med.uni-goettingen.de
Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany
Clinic for Cardiology and Pneumology, University Hospital Göttingen, Robert-Koch-Strasse 40, Göttingen, 37075, Germany
DZHK (German Centre for Cardiovascular Research) Partner Site Göttingen, Göttingen, Germany
Cluster of Excellence MBExC, University of Göttingen & University Medical Center Göttingen, Göttingen, Germany