Glecirasib with or without cetuximab in previously treated locally advanced or metastatic colorectal cancer with KRASG12C mutation (JAB-21822-1002 and JAB-21822-1007): two open-label, non-randomised phase 1/2 trials
Year: 2025
Type: article
Language: en
Topic: Colorectal Cancer Treatments and Studies
Authors and affiliations:
raw_author_name: Jian Li
raw_affiliation_strings: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Peking University Cancer Hospital & Institute, Beijing, China; Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China
raw_author_name: Zhenghang Wang
raw_affiliation_strings: Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China
Department of Oncology, Linyi Cancer Hospital, Linyi, China
raw_author_name: Jing Huang
raw_affiliation_strings: Department of Medical Oncology, Cancer Hospital Chinese Academy of Medical Science, Beijing, China
raw_author_name: Yi Ba
raw_affiliation_strings: Department of Gastrointestinal Medical Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China
raw_author_name: Baoshan Cao
raw_affiliation_strings: Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hospital, Beijing, China
raw_author_name: Suxia Luo
raw_affiliation_strings: Department of Medical Oncology, Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
raw_author_name: Wenhua Li
raw_affiliation_strings: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
raw_author_name: Chunmei Bai
raw_affiliation_strings: Department of Medical Oncology, Peking Union Medical College Hospital, Beijing, China
raw_author_name: Zhengbo Song
raw_affiliation_strings: Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, China
raw_author_name: Jianping Xiong
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, China
raw_author_name: Liangjun Zhu
raw_affiliation_strings: Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, China
raw_author_name: Guangyu An
raw_affiliation_strings: Department of Medical Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
raw_author_name: Yanqiao Zhang
raw_affiliation_strings: Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China
raw_author_name: Zhihua Li
raw_affiliation_strings: Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Guangzhou, China
Department of Oncology, Linyi Cancer Hospital, Linyi, China
raw_author_name: Yongsheng Li
raw_affiliation_strings: Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, China
raw_author_name: Yanhong Gu
raw_affiliation_strings: Department of Oncology, Jiangsu Province Hospital, Nanjing, China
raw_author_name: Changlu Hu
raw_affiliation_strings: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, China
raw_author_name: Xingya Li
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Department of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
raw_author_name: Chenghui Huang
raw_affiliation_strings: Department of Oncology, The Third Xiangya Hospital, Central South University, Changsha, China
raw_author_name: Qihan Fu
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
raw_author_name: Xianli Yin
raw_affiliation_strings: Department of Gastroenterology and Urology, Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
raw_author_name: Xinjun Liang
raw_affiliation_strings: Department of Medical Oncology, Hubei Cancer Hospital, Wuhan, China
raw_author_name: Diansheng Zhong
raw_affiliation_strings: Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China
raw_author_name: Huaqiu Shi
raw_affiliation_strings: Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China
raw_author_name: Xiaoyan Li
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Department of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
raw_author_name: Zhen Li
raw_affiliation_strings: Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Guangzhou, China
Department of Oncology, Linyi Cancer Hospital, Linyi, China
raw_author_name: Lian Liu
raw_affiliation_strings: Department of Medical Oncology, Qilu Hospital of Shandong University, Jinan, China
raw_author_name: Feng Wang
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
raw_author_name: Rong Liang
raw_affiliation_strings: Department of Digestive Oncology, Guangxi Medical University Cancer Hospital, Nanning, China
raw_author_name: Guohao Xia
raw_affiliation_strings: Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, China
raw_author_name: Zhen Wang
raw_affiliation_strings: Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China
Department of Oncology, Linyi Cancer Hospital, Linyi, China
raw_author_name: Andrea Wang-Gillam
raw_affiliation_strings: Jacobio Pharmaceuticals, Burlington, MA, USA
raw_author_name: Yuli Ding
raw_affiliation_strings: Jacobio Pharmaceuticals, Beijing, China
raw_author_name: Zhiyue Rao
raw_affiliation_strings: Jacobio Pharmaceuticals, Beijing, China
raw_author_name: Wenhui Pan
raw_affiliation_strings: Jacobio Pharmaceuticals, Beijing, China
raw_author_name: Shuang Lu
raw_affiliation_strings: Jacobio Pharmaceuticals, Beijing, China
raw_author_name: Xin Sun
raw_affiliation_strings: Jacobio Pharmaceuticals, Beijing, China
raw_author_name: Lin Shen
raw_affiliation_strings: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Peking University Cancer Hospital & Institute, Beijing, China; Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China. Electronic address: shenlin@bjmu.edu.cn