IgG-Bridging–Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by A Low-Affinity Antibody
Year: 2025
Type: preprint
Topic: SARS-CoV-2 and COVID-19 Research
Authors and affiliations:
raw_author_name: Niannian Lv
raw_affiliation_strings: National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
raw_author_name: Peng Chen
raw_affiliation_strings: Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China;
raw_author_name: Xiaobin Dai
raw_affiliation_strings: State Key Laboratory of Chemical Engineering, Department of Chemical Engineering and Low-carbon Technology, Tsinghua University, Beijing, China;
raw_author_name: Hu Xu
raw_affiliation_strings: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, China;
raw_author_name: Ziheng Li
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Zelin Shan
raw_affiliation_strings: The Salk Institute of Biological Sciences, La Jolla, California, USA;
raw_author_name: Jinqian Li
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China;
raw_author_name: Fenglin Guo
raw_affiliation_strings: The Ministry of Education Key Laboratory of Protein Science, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, 100084, Beijing, China;
raw_author_name: Yuanfang Chen
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Jiayi Li
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China;
raw_author_name: Yiqian Huang
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Guizhi Dong
raw_affiliation_strings: CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China;
raw_author_name: Yifan Jiang
raw_affiliation_strings: tsinghua university;
raw_author_name: Liang Chen
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Xuanyu Nan
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Hanjun Zhao
raw_affiliation_strings: Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Medical College, Fudan University, China;
raw_author_name: Kang Zhang
raw_affiliation_strings: CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Shilong Fan
raw_affiliation_strings: The technology center for protein science, Tsinghua University, Beijing, China;
raw_author_name: Yuanchen Dong
raw_affiliation_strings: CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China;
raw_author_name: Dongsheng Liu
raw_affiliation_strings: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Hum, Kowloon, 999077 Hong Kong;
raw_author_name: Xinquan Wang
raw_affiliation_strings: Tsinghua University;
raw_author_name: Deli Huang
raw_affiliation_strings: Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China;
raw_author_name: Xiaojing Pan
raw_affiliation_strings: Institute of Bio-Architecture and Bio-Interactions, Shenzhen Medical Academy of Research and Translation, Shenzhen 518107, Guangdong Province, China;
raw_author_name: Chunying Chen
raw_affiliation_strings: National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Zhihua Liu
raw_affiliation_strings: Chinese Academy of Medical Sciences & Peking Union Medical College;
raw_author_name: Li-Tang Yan
raw_affiliation_strings: State Key Laboratory of Chemical Engineering, Department of Chemical Engineering and Low-carbon Technology, Tsinghua University, Beijing, China;
raw_author_name: Qi Zhang
raw_affiliation_strings: Tsinghua University;
raw_author_name: Lin Qi Zhang
raw_affiliation_strings: Tsinghua University;
raw_author_name: Yuliang Zhao
raw_affiliation_strings: National Center for Nanoscience and Technology, Beijing, China;
raw_author_name: Yuhe Renee Yang
raw_affiliation_strings: National Center for Nanoscience and Technology