Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
Year: 2025
Type: article
Language: en
Topic: Alzheimer's disease research and treatments
Authors and affiliations:
raw_author_name: Kalyani Chaubey
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Edwin Vázquez-Rosa
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Sunil Jamuna Tripathi
raw_affiliation_strings: Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Min-Kyoo Shin
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08226, Republic of Korea; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
raw_author_name: Youngmin Yu
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USA
raw_author_name: Matasha Dhar
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Suwarna Chakraborty
raw_affiliation_strings: Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Mai Yamakawa
raw_affiliation_strings: Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
raw_author_name: Xinming Wang
raw_affiliation_strings: Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Preethy S. Sridharan
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Emiko Miller
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Zea Bud
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raw_author_name: Sofia G. Corella
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raw_author_name: Sarah Barker
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Salvatore G. Caradonna
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raw_author_name: Yeojung Koh
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Kathryn Franke
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raw_author_name: Coral J. Cintrón-Pérez
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raw_author_name: Sophia Rose
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raw_author_name: Hua Fang
raw_affiliation_strings: Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Hathaway Brown School, Shaker Heights, OH 44122, USA; Massachusetts Institute of Technology, Cambridge, MA 02139, USA
raw_author_name: Adrian A. Cintrón-Pérez
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raw_author_name: Taylor Tomco
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raw_author_name: Xiongwei Zhu
raw_affiliation_strings: Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
raw_author_name: Hisashi Fujioka
raw_affiliation_strings: Cryo-Electron Microscopy Core, Case Western Reserve University School of Medicine, Cleveland, OH, USA
raw_author_name: Tamar Gefen
raw_affiliation_strings: Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
raw_author_name: Margaret E. Flanagan
raw_affiliation_strings: Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Glenn Bigg's Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX 78229, USA; Departments of Pathology and Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
raw_author_name: Noelle S. Williams
raw_affiliation_strings: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
raw_author_name: Brigid M. Wilson
raw_affiliation_strings: Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA; Division of Infectious Diseases and HIV Medicine in the Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Lawrence Chen
raw_affiliation_strings: Lawrence Chen Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
raw_author_name: Lijun Dou
raw_affiliation_strings: Department of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44106, USA
raw_author_name: Feixiong Cheng
raw_affiliation_strings: Department of Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44106, USA; Cleveland Clinic Genome Center, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44106, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: Jessica E. Rexach
raw_affiliation_strings: Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
raw_author_name: Jung-A Woo
raw_affiliation_strings: Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
raw_author_name: David E. Kang
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raw_author_name: Bindu D. Paul
raw_affiliation_strings: Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Lieber Institute for Brain Development, Baltimore, MD 21205, USA
raw_author_name: Andrew A. Pieper
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