Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation
Year: 2025
Type: article
Language: en
Topic: Protein Degradation and Inhibitors
Authors and affiliations:
raw_author_name: Daniel Schäfer
raw_affiliation_strings: Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 15 D‐60438 Frankfurt am Main Germany
Frankfurt Cancer Institute  Paul‐Ehrlich‐Str. 42–44 D‐60596 Frankfurt am Main Germany
Institute for Pharmaceutical Chemistry Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 9 D‐60438 Frankfurt am Main Germany
raw_author_name: Cristian Prieto‐Garcia
raw_affiliation_strings: Institute of Biochemistry II Frankfurt University Hospital Building 75, Faculty of Medicine Frankfurt am Main  Theodor‐Stern‐Kai 7 D‐60596 Frankfurt am Main Germany
raw_author_name: Jianhui Wang
raw_affiliation_strings: Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 15 D‐60438 Frankfurt am Main Germany
Institute for Pharmaceutical Chemistry Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 9 D‐60438 Frankfurt am Main Germany
raw_author_name: Marcel Heinz
raw_affiliation_strings: Department of Theoretical Biophysics Max Planck Institute of Biophysics  Max‐von‐Laue‐Str. 3 60438 Frankfurt am Main Germany
raw_author_name: Vigor Matkovic
raw_affiliation_strings: Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 15 D‐60438 Frankfurt am Main Germany
Institute of Biochemistry II Frankfurt University Hospital Building 75, Faculty of Medicine Frankfurt am Main  Theodor‐Stern‐Kai 7 D‐60596 Frankfurt am Main Germany
raw_author_name: Pavel Kielkowski
raw_affiliation_strings: Department of Chemistry Ludwig Maximilian University München  Würmtalstrasse 201 81375 Munich Germany
raw_author_name: Sebastian Hasselbeck
raw_affiliation_strings: Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 15 D‐60438 Frankfurt am Main Germany
Institute for Pharmaceutical Chemistry Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 9 D‐60438 Frankfurt am Main Germany
raw_author_name: Varun Jayeshkumar Shah
raw_affiliation_strings: Institute of Biochemistry II Frankfurt University Hospital Building 75, Faculty of Medicine Frankfurt am Main  Theodor‐Stern‐Kai 7 D‐60596 Frankfurt am Main Germany
raw_author_name: Stefan Knapp
raw_affiliation_strings: Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 15 D‐60438 Frankfurt am Main Germany
Frankfurt Cancer Institute  Paul‐Ehrlich‐Str. 42–44 D‐60596 Frankfurt am Main Germany
Institute for Pharmaceutical Chemistry Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 9 D‐60438 Frankfurt am Main Germany
raw_author_name: Gerhard Hummer
raw_affiliation_strings: Department of Theoretical Biophysics Max Planck Institute of Biophysics  Max‐von‐Laue‐Str. 3 60438 Frankfurt am Main Germany
Institute of Biophysics Johann Wolfgang Goethe‐University  Max‐von‐Laue‐Str. 1 D‐60438 Frankfurt am Main Germany
raw_author_name: Ivan Dikic
raw_affiliation_strings: Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 15 D‐60438 Frankfurt am Main Germany
Institute of Biochemistry II Frankfurt University Hospital Building 75, Faculty of Medicine Frankfurt am Main  Theodor‐Stern‐Kai 7 D‐60596 Frankfurt am Main Germany
raw_author_name: Xinlai Cheng
raw_affiliation_strings: Buchmann Institute for Molecular Life Sciences Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 15 D‐60438 Frankfurt am Main Germany
Frankfurt Cancer Institute  Paul‐Ehrlich‐Str. 42–44 D‐60596 Frankfurt am Main Germany
Institute for Pharmaceutical Chemistry Johann Wolfgang Goethe‐University Frankfurt am Main  Max‐von‐Laue‐Str. 9 D‐60438 Frankfurt am Main Germany
Mildred‐Scheel‐Nachwuchszentrum (MSNZ) University Cancer Center (UCT) Frankfurt University Hospital Frankfurt am Main  Theodor‐Stern‐Kai 7 D‐60596 Frankfurt am Main Germany