4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy
Year: 2025
Type: article
Language: en
Topic: Alzheimer's disease research and treatments
Authors and affiliations:
raw_author_name: Ivan Martinez-Valbuena
raw_affiliation_strings: Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Seojin Lee
raw_affiliation_strings: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Enrique Santamaria
raw_affiliation_strings: Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, Spain
raw_author_name: Joaquín Fernández-Irigoyen
raw_affiliation_strings: Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, Spain
raw_author_name: Shelley L. Forrest
raw_affiliation_strings: Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia
Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Silvia Zampar
raw_affiliation_strings: Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Jun Li
raw_affiliation_strings: Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Hidetomo Tanaka
raw_affiliation_strings: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Blas Couto
raw_affiliation_strings: Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
Institute of Cognitive and Translational Neuroscience (INCyT-INECO), Buenos Aires, Argentina
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
raw_author_name: Nikolai Gil D. Reyes
raw_affiliation_strings: Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
raw_author_name: Syeda Hania Qamar
raw_affiliation_strings: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Ali M. Karakani
raw_affiliation_strings: Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Ain Kim
raw_affiliation_strings: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Konstantin Senkevich
raw_affiliation_strings: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada
raw_author_name: Ekaterina Rogaeva
raw_affiliation_strings: Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Susan H. Fox
raw_affiliation_strings: Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
raw_author_name: M. Carmela Tartaglia
raw_affiliation_strings: Department of Medicine, University of Toronto, Toronto, ON, Canada
Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
University Health Network Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada
raw_author_name: Naomi P. Visanji
raw_affiliation_strings: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Martin Ingelsson
raw_affiliation_strings: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Department of Medicine, University of Toronto, Toronto, ON, Canada
Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
University Health Network Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada
raw_author_name: Tallulah Andrews
raw_affiliation_strings: Department of Biochemistry, University of Western Ontario, London, ON, Canada
Department of Computer Science, University of Western Ontario, London, ON, Canada
raw_author_name: Anthony E. Lang
raw_affiliation_strings: Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
Krembil Brain Institute, University Health Network, Toronto, ON, Canada
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
raw_author_name: Gabor G. Kovacs
raw_affiliation_strings: Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia. gabor.kovacs@uhn.ca
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca
Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada. gabor.kovacs@uhn.ca
Krembil Brain Institute, University Health Network, Toronto, ON, Canada. gabor.kovacs@uhn.ca
Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada. gabor.kovacs@uhn.ca
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca