The Alzheimer’s disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states
Year: 2025
Type: article
Language: en
Topic: Neuroinflammation and Neurodegeneration Mechanisms
Authors and affiliations:
raw_author_name: Dalya Rosner
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA. Electronic address: dalya.rosner@gmail.com
raw_author_name: Jiahong Sun
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Rita Cacace
raw_affiliation_strings: Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium
raw_author_name: Angie Yee
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Chaitanya Wagh
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Anna Rychkova
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Mariah Dunlap
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Daniel Gulbranson
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Adiljan Ibrahim
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Xiaoting Wang
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Rebecca Wang
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Alice Buonfiglioli
raw_affiliation_strings: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
raw_author_name: Muhammad Alhawagri
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Phil Kong
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Marina Roell
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Wei-Hsien Ho
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Belvin Gong
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Heidi Denton
raw_affiliation_strings: Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium
raw_author_name: Giacomo Muscarnera
raw_affiliation_strings: Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium
raw_author_name: Tim Meese
raw_affiliation_strings: Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium
raw_author_name: Malak El-Khatib
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Daniel Bermingham
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Elias Kahn
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Francesca Cignarella
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Herve Rhinn
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Zia Khan
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Tina Schwabe
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Karpagam Srinivisan
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Ananya Mitra
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Lotje de Witte
raw_affiliation_strings: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
raw_author_name: Peter Heutink
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Renzo Mancuso
raw_affiliation_strings: Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium
raw_author_name: Ilaria Tassi
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Julia Kuhn
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Hua Long
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Sara Kenkare-Mitra
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA
raw_author_name: Arnon Rosenthal
raw_affiliation_strings: Alector, Inc., South San Francisco, CA 94080, USA