Intravenous administration of EXG110 resulted in substrate correction in Fabry mice and sustained enzyme activity in non-human primates
Year: 2025
Type: article
Language: en
Topic: Lysosomal Storage Disorders Research
Authors and affiliations:
raw_author_name: Shaoyong Li
raw_affiliation_strings: Exegenesis Bio Co., 206 Welsh Road, Horsham, PA 19044, USA
raw_author_name: Pengfei Yu
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Hong Wang
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Mingwen Liu
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Qingzeng Wang
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Zhongwan Li
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Shuyuan Chen
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Chentao He
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Bryan Yue Zhan
raw_affiliation_strings: Exegenesis Bio Co., 206 Welsh Road, Horsham, PA 19044, USA
raw_author_name: Lucas Song Tong
raw_affiliation_strings: Exegenesis Bio Co., 206 Welsh Road, Horsham, PA 19044, USA
raw_author_name: Xinyi Shou
raw_affiliation_strings: Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
raw_author_name: Jingjing Luo
raw_affiliation_strings: Gene Therapy Center, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
raw_author_name: Xiaoyuan Jia
raw_affiliation_strings: Gene Therapy Center, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
raw_author_name: Xin Xin
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Wei Hu
raw_affiliation_strings: Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Zhihong Lu
raw_affiliation_strings: Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
raw_author_name: Yigang Wang
raw_affiliation_strings: Gene Therapy Center, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
raw_author_name: Guojie Ye
raw_affiliation_strings: Exegenesis Bio Co., 206 Welsh Road, Horsham, PA 19044, USA; Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China
raw_author_name: Jianhua Mao
raw_affiliation_strings: Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China. Electronic address: maojh88@zju.edu.cn
raw_author_name: Zhenhua Wu
raw_affiliation_strings: Gene Therapy Center, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China; Exegenesis Bio Co., 206 Welsh Road, Horsham, PA 19044, USA; Hangzhou Jiayin Biotech Ltd., Hexiang Tech Center, Qiantang District, Hangzhou 310018, China. Electronic address: zhenhuawu@exegenesisbio.com