Paeoniflorin derivative ameliorates methotrexate resistance in treating rheumatoid arthritis through targeting GRK2-A2AAR axis
Year: 2025
Type: article
Language: en
Topic: Receptor Mechanisms and Signaling
Authors and affiliations:
raw_author_name: Paipai Guo
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China; Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
raw_author_name: Rui Wang
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Meiyue Lu
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Mingzhu Wang
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Rui Chu
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Shuoshuo Hu
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Huihui Xu
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Ruhong Fang
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Zhenduo Zhu
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China
raw_author_name: Jing Cai
raw_affiliation_strings: Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
raw_author_name: Yongsheng Han
raw_affiliation_strings: Department of Emergency Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230002, China
raw_author_name: Chun Wang
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China. Electronic address: wangchun@ahmu.edu.cn
raw_author_name: Wei Wei
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China. Electronic address: wwei@ahmu.edu.cn
raw_author_name: Qingtong Wang
raw_affiliation_strings: School of Pharmacy, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-inflammatory and Immune Medicines, Hefei 230032, China; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address: hfwqt727@163.com