Chemical modification of STL427944 toward morpholine-based 1,3,5-triazines as anticancer agents targeting FOXM1: green synthesis, biological evaluation and ADME-Tox profiling in a colorectal cancer model
Year: 2025
Type: article
Language: en
Topic: Synthesis and Characterization of Heterocyclic Compounds
Authors and affiliations:
raw_author_name: Damian Kułaga
raw_affiliation_strings: Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155, Cracow, Poland; Institute of Veterinary Sciences, University Center of Veterinary Medicine UJ-UR, University of Agriculture in Cracow, 24/28 Mickiewicza Street, 30-059, Cracow, Poland. Electronic address: damian.kulaga@pk.edu.pl
raw_author_name: Natalia Bosak
raw_affiliation_strings: Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155, Cracow, Poland
raw_author_name: Magda Ptaszkiewicz
raw_affiliation_strings: Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155, Cracow, Poland
raw_author_name: Julia Chrzan
raw_affiliation_strings: Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155, Cracow, Poland
raw_author_name: Katarzyna Staroń
raw_affiliation_strings: Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155, Cracow, Poland
raw_author_name: Kamila Marzec
raw_affiliation_strings: Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155, Cracow, Poland
raw_author_name: Anna K. Drabczyk
raw_affiliation_strings: Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155, Cracow, Poland
raw_author_name: Izabela Siemieńska
raw_affiliation_strings: Institute of Veterinary Sciences, University Center of Veterinary Medicine UJ-UR, University of Agriculture in Cracow, 24/28 Mickiewicza Street, 30-059, Cracow, Poland
raw_author_name: Marta Kot
raw_affiliation_strings: Department of Transplantation, Faculty of Medicine, Jagiellonian University Medical College, 265 Wielicka Street, 30-663, Cracow, Poland
raw_author_name: Gniewomir Latacz
raw_affiliation_strings: Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland
raw_author_name: Joanna Karnafał
raw_affiliation_strings: Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland
raw_author_name: Carlos A. Velázquez-Martínez
raw_affiliation_strings: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2E1, Canada
raw_author_name: Katarzyna Malarz
raw_affiliation_strings: Chełkowski Institute of Physics, University of Silesia, 75 Pułku Piechoty 1A, 41-500, Chorzów, Poland
raw_author_name: Anna Mrozek-Wilczkiewicz
raw_affiliation_strings: Chełkowski Institute of Physics, University of Silesia, 75 Pułku Piechoty 1A, 41-500, Chorzów, Poland
raw_author_name: Anna Boguszewska-Czubara
raw_affiliation_strings: Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a Street, 20-093, Lublin, Poland
raw_author_name: Katarzyna Greber
raw_affiliation_strings: Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, 107 General Jozef Haller Avenue, 80-416, Gdansk, Poland
raw_author_name: Krzesimir Ciura
raw_affiliation_strings: Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, 107 General Jozef Haller Avenue, 80-416, Gdansk, Poland