Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity
Year: 2025
Type: article
Language: en
Topic: Immune cells in cancer
Authors and affiliations:
raw_author_name: Louise Gorline
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
raw_author_name: Fillipe Luiz Rosa do Carmo
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
raw_author_name: Pierre Bourdely
raw_affiliation_strings: INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France
Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium
raw_author_name: Jérémie Bornères
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
raw_author_name: Nathan Vaudiau
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
raw_author_name: Aurélie Semervil
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France
raw_author_name: Mathias Vetillard
raw_affiliation_strings: Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France
raw_author_name: Aboubacar Sidiki K Coulibaly
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
raw_author_name: Natacha Jugniot
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
raw_author_name: Agathe Ok
raw_affiliation_strings: Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France
raw_author_name: Mathilde Bausart
raw_affiliation_strings: Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland
raw_author_name: Oriane Fiquet
raw_affiliation_strings: Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France
raw_author_name: Marine Andrade
raw_affiliation_strings: Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France
raw_author_name: Dicken Fardol
raw_affiliation_strings: Nutrition and Obesity: Systemic Approaches, Inserm, Sorbonne University, Paris, France
raw_author_name: Ikrame Haddar
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France
raw_author_name: Zeina Abou Nader
raw_affiliation_strings: INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France
raw_author_name: Judith Weber
raw_affiliation_strings: INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France
raw_author_name: Hannah Theobald
raw_affiliation_strings: Inserm U1015, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France
raw_author_name: Matthieu Collin
raw_affiliation_strings: Inserm Transfert, Paris, France
raw_author_name: Joseph Calmette
raw_affiliation_strings: Inserm Transfert, Paris, France
raw_author_name: Giorgio Anselmi
raw_affiliation_strings: Deparment of Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
raw_author_name: Flavia Fico
raw_affiliation_strings: Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland
raw_author_name: Florent Ginhoux
raw_affiliation_strings: Inserm U1015, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France
raw_author_name: Laleh Majlessi
raw_affiliation_strings: Virology Department, Pasteur-TheraVectys Joint Laboratory, Institut Pasteur, Université Paris Cité, Paris, France
raw_author_name: Emmanuel L. Gautier
raw_affiliation_strings: Nutrition and Obesity: Systemic Approaches, Inserm, Sorbonne University, Paris, France
raw_author_name: Loredana Saveanu
raw_affiliation_strings: Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France
raw_author_name: Julie Helft
raw_affiliation_strings: INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France
raw_author_name: Marc Dalod
raw_affiliation_strings: Centre d'Immunologie de Marseille-Luminy, CIML, CNRS, INSERM, Aix Marseille Université, Marseille, France
raw_author_name: Mathilde Dusseaux
raw_affiliation_strings: Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France
raw_author_name: James P. Di Santo
raw_affiliation_strings: Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France
Immunology Department, Immunité Innée, Institut Pasteur, Paris, France
raw_author_name: Stéphanie Hugues
raw_affiliation_strings: Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland
raw_author_name: Pierre Guermonprez
raw_affiliation_strings: CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France. pierre.guermonprez@pasteur.fr
Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France. pierre.guermonprez@pasteur.fr
Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France. pierre.guermonprez@pasteur.fr