Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma
Year: 2025
Type: article
Language: en
Topic: Glioma Diagnosis and Treatment
Authors and affiliations:
raw_author_name: Nicholas R. Fernandez
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Yuan Chang
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Nuno M. Nunes
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Jose R. Dimayacyac
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Adrian Levine
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Amit Ringel
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Logine Negm
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Ayse Bahar Ercan
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Julian M. Hess
raw_affiliation_strings: Broad Institute of MIT and Harvard, Cambridge, MA, USA
raw_author_name: Olfat Ahmad
raw_affiliation_strings: Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany
Division of Pediatric Neurooncology, Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany
raw_author_name: Caitlin Lee
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Lucie Stengs
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Vanessa Bianchi
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Melissa Edwards
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Sheradan Doherty
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Jiil Chung
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
raw_author_name: Liana Nobre
raw_affiliation_strings: Department of Pediatric Hematology-Oncology, Stollery Children Hospital, University of Alberta, Edmonton, Alberta, Canada
raw_author_name: Julie Bennett
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
raw_author_name: Andrew J. Dodgshun
raw_affiliation_strings: Children's Hematology/Oncology Centre, Christchurch Hospital, Christchurch, New Zealand
raw_author_name: David T. W. Jones
raw_affiliation_strings: Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Stefan M. Pfister
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and NCT, Heidelberg, Germany
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany
raw_author_name: Anita Villani
raw_affiliation_strings: Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: David Malkin
raw_affiliation_strings: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Vijay Ramaswamy
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Annie Huang
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Eric Bouffet
raw_affiliation_strings: Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Melyssa Aronson
raw_affiliation_strings: Zane Cohen Centre for Digestive Diseases, Sinai Health System, Toronto, Ontario, Canada
raw_author_name: Peter B. Dirks
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Adam Shlien
raw_affiliation_strings: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Gad Getz
raw_affiliation_strings: Broad Institute of MIT and Harvard, Cambridge, MA, USA
Department of Pathology, Harvard Medical School, Boston, MA, USA
Krantz Family Center for Cancer Research and Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Yosef E. Maruvka
raw_affiliation_strings: Technion-Israel Institute of Technology, Tel-Aviv, Israel
raw_author_name: Birgit Ertl-Wagner
raw_affiliation_strings: Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
Division of Neuroradiology, Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada
Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada
raw_author_name: Cynthia Hawkins
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Anirban Das
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
raw_author_name: Uri Tabori
raw_affiliation_strings: Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada. uri.tabori@sickkids.ca
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. uri.tabori@sickkids.ca
Division of Haematology & Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. uri.tabori@sickkids.ca