Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion
Year: 2025
Type: article
Language: en
Topic: Genomics and Chromatin Dynamics
Authors and affiliations:
raw_author_name: Lucas Ferreira DaSilva
raw_affiliation_strings: Department of Pathology, Harvard Medical School, Boston, MA, USA
Molecular Pathology Unit and Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Simon Senan
raw_affiliation_strings: Broad Institute of Harvard and MIT, Cambridge, MA, USA
Molecular Pathology Unit and Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Judith F. Kribelbauer-Swietek
raw_affiliation_strings: Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA
Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
raw_author_name: Zain Munir Patel
raw_affiliation_strings: Broad Institute of Harvard and MIT, Cambridge, MA, USA
Department of Pathology, Harvard Medical School, Boston, MA, USA
Molecular Pathology Unit and Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Lithin Karmel Louis
raw_affiliation_strings: Victor Chang Cardiac Institute, Darlinghurst, New South Wales, Australia
raw_author_name: Aniketh Janardhan Reddy
raw_affiliation_strings: Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA
raw_author_name: Sameer Gabbita
raw_affiliation_strings: Johns Hopkins University, Baltimore, MD, USA
Molecular Pathology Unit and Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Jonathan D. Rosen
raw_affiliation_strings: Department of Genetics, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
raw_author_name: Zach Nussbaum
raw_affiliation_strings: Independent researcher, New York, NY, USA
raw_author_name: César Miguel Valdez Córdova
raw_affiliation_strings: Quantitative Life Sciences, McGill University, Montreal, QC, Canada; Mila-Québec AI Institute, Montreal, QC, Canada
raw_author_name: Aaron Wenteler
raw_affiliation_strings: Queen Mary University of London, London, UK
raw_author_name: Noah Weber
raw_affiliation_strings: Cosmon, San Francisco, CA, USA
raw_author_name: Tin M. Tunjic
raw_affiliation_strings: Axion Labs Inc, San Francisco, CA, USA
raw_author_name: Martino Mansoldo
raw_affiliation_strings: GSK.ai, London, UK
Independent researcher, London, UK
raw_author_name: Talha Ahmad Khan
raw_affiliation_strings: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA
Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA
Independent researcher, Pittsburgh, PA, USA
raw_author_name: Gue-Ho Hwang
raw_affiliation_strings: Department of Pathology, Harvard Medical School, Boston, MA, USA
Molecular Pathology Unit and Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Vincent Gardeux
raw_affiliation_strings: Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
raw_author_name: David T. Humphreys
raw_affiliation_strings: School of Clinical Medicine, UNSW Sydney, Sydney, Australia
Victor Chang Cardiac Institute, Darlinghurst, New South Wales, Australia
raw_author_name: Cameron Smith
raw_affiliation_strings: Broad Institute of Harvard and MIT, Cambridge, MA, USA
Department of Pathology, Harvard Medical School, Boston, MA, USA
Molecular Pathology Unit and Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Matei Bejan
raw_affiliation_strings: University of Bucharest, Bucharest, Romania
raw_author_name: Peter Bromley
raw_affiliation_strings: Altius Institute for Biomedical Sciences, Seattle, WA, USA
raw_author_name: Will Connell
raw_affiliation_strings: Independent researcher, Berkeley, CA, USA
raw_author_name: Bart Deplancke
raw_affiliation_strings: Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
raw_author_name: Michael I. Love
raw_affiliation_strings: Department of Genetics, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
raw_author_name: Emily S. Wong
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, Australia
Victor Chang Cardiac Institute, Darlinghurst, New South Wales, Australia
raw_author_name: Wouter Meuleman
raw_affiliation_strings: Altius Institute for Biomedical Sciences, Seattle, WA, USA
Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA
raw_author_name: Luca Pinello
raw_affiliation_strings: Broad Institute of Harvard and MIT, Cambridge, MA, USA. lpinello@mgh.harvard.edu
Department of Pathology, Harvard Medical School, Boston, MA, USA. lpinello@mgh.harvard.edu
Molecular Pathology Unit and Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. lpinello@mgh.harvard.edu