Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities
Year: 2025
Type: article
Language: en
Topic: Protein Degradation and Inhibitors
Authors and affiliations:
raw_author_name: Jianfeng Ge
raw_affiliation_strings: Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK
MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK
raw_author_name: Shoko Hirosue
raw_affiliation_strings: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK
raw_author_name: Leticia Castillon
raw_affiliation_strings: Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland
raw_author_name: Saroor A Patel
raw_affiliation_strings: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK
Wellcome Sanger Institute, Cambridge, UK
raw_author_name: Ludovic Wesolowski
raw_affiliation_strings: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK
raw_author_name: Anna Dyas
raw_affiliation_strings: Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK
MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK
raw_author_name: Cissy Yong
raw_affiliation_strings: Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Department of Surgery, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
raw_author_name: Sanne de Haan
raw_affiliation_strings: Princess Máxima Center for Pediatric Oncology, Oncode Institute, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands
raw_author_name: Jarno Drost
raw_affiliation_strings: Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Oncode Institute, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands
raw_author_name: Grant D Stewart
raw_affiliation_strings: Department of Surgery, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
raw_author_name: Anna C Obenauf
raw_affiliation_strings: Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
raw_author_name: Daniel Muñoz-Espín
raw_affiliation_strings: Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK. dm742@cam.ac.uk
Thoracic Cancer Programme, CRUK Cambridge Centre, Cambridge, UK. dm742@cam.ac.uk
Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK
raw_author_name: Sakari Vanharanta
raw_affiliation_strings: Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. sakari.vanharanta@helsinki.fi
MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK. sakari.vanharanta@helsinki.fi
Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. sakari.vanharanta@helsinki.fi
Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland