A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity
Year: 2025
Type: article
Language: en
Topic: SARS-CoV-2 and COVID-19 Research
Authors and affiliations:
raw_author_name: Shuhei Tsujino
raw_affiliation_strings: Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Department of Virology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
raw_author_name: Masumi Tsuda
raw_affiliation_strings: Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Japan
raw_author_name: Sayaka Deguchi
raw_affiliation_strings: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
Department of Synthetic Human Body System, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan
raw_author_name: Jumpei Ito
raw_affiliation_strings: Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
raw_author_name: Taha Y. Taha
raw_affiliation_strings: Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA
Gladstone Institutes, San Francisco, CA, USA
raw_author_name: Hesham Nasser
raw_affiliation_strings: Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan
raw_author_name: Lei Wang
raw_affiliation_strings: Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Japan
raw_author_name: Julia Rosecrans
raw_affiliation_strings: Gladstone Institutes, San Francisco, CA, USA
raw_author_name: Rigel Suzuki
raw_affiliation_strings: Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Department of Virology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan
raw_author_name: Saori Suzuki
raw_affiliation_strings: Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Department of Virology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan
raw_author_name: Kumiko Yoshimatsu
raw_affiliation_strings: Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
raw_author_name: Melanie Ott
raw_affiliation_strings: Chan Zuckerberg Biohub-San Francisco, San Francisco, CA, USA
Department of Medicine, University of California, San Francisco, CA, USA
Gladstone Institutes, San Francisco, CA, USA
raw_author_name: Terumasa Ikeda
raw_affiliation_strings: Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan
raw_author_name: Kei Sato
raw_affiliation_strings: Collaboration Unit for Infection, Joint Research Center for Human Retrovirus infection, Kumamoto University, Kumamoto, Japan
Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
MRC-University of Glasgow Centre for Virus Research, Glasgow, UK
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
raw_author_name: Kazuo Takayama
raw_affiliation_strings: AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan. takayama.kazuo@tmd.ac.jp
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. takayama.kazuo@tmd.ac.jp
Department of Synthetic Human Body System, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan. takayama.kazuo@tmd.ac.jp
Department of Synthetic Human Body System, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan
raw_author_name: Shinya Tanaka
raw_affiliation_strings: Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan. tanaka@med.hokudai.ac.jp
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Japan. tanaka@med.hokudai.ac.jp
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Japan
raw_author_name: Tomokazu Tamura
raw_affiliation_strings: Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan. tamura.tomokazu.956@m.kyushu-u.ac.jp
Department of Virology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. tamura.tomokazu.956@m.kyushu-u.ac.jp
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan. tamura.tomokazu.956@m.kyushu-u.ac.jp
Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan. tamura.tomokazu.956@m.kyushu-u.ac.jp
One Health Research Center, Hokkaido University, Sapporo, Japan. tamura.tomokazu.956@m.kyushu-u.ac.jp
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
raw_author_name: Takasuke Fukuhara
raw_affiliation_strings: AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan. fukuhara.takasuke.169@m.kyushu-u.ac.jp
Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan. fukuhara.takasuke.169@m.kyushu-u.ac.jp
Department of Virology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. fukuhara.takasuke.169@m.kyushu-u.ac.jp
Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan. fukuhara.takasuke.169@m.kyushu-u.ac.jp
Laboratory of Virus Control, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan. fukuhara.takasuke.169@m.kyushu-u.ac.jp
One Health Research Center, Hokkaido University, Sapporo, Japan. fukuhara.takasuke.169@m.kyushu-u.ac.jp
Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
raw_author_name: Hirofumi Sawa
raw_affiliation_strings: Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan
International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan
One Health Research Center, Hokkaido University, Sapporo, Japan
raw_author_name: Keita Matsuno
raw_affiliation_strings: Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan
Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan
International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan
One Health Research Center, Hokkaido University, Sapporo, Japan
raw_author_name: Yuma Ohari
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raw_author_name: Keita Mizuma
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raw_author_name: Jingshu Li
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raw_author_name: Yume Mimura
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raw_author_name: Naganori Nao
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Institute for Vaccine Research and Development (IVReD), Hokkaido University, Sapporo, Japan
One Health Research Center, Hokkaido University, Sapporo, Japan
raw_author_name: Yoshitaka Oda
raw_affiliation_strings: Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Japan
raw_author_name: Kenji Shishido
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raw_author_name: Hayato Ito
raw_affiliation_strings: Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan
raw_author_name: Naoko Misawa
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raw_author_name: Keiya Uriu
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raw_author_name: Shusuke Kawakubo
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raw_author_name: Spyros Lytras
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raw_author_name: Arnon Plianchaisuk
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raw_author_name: Ziyi Guo
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raw_author_name: Alfredo Hinay
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raw_author_name: Wilaiporn Saikruang
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raw_author_name: Kaoru Usui
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raw_author_name: Luca Nishimura
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raw_author_name: Yusuke Kosugi
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raw_author_name: Shigeru Fujita
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Department of Synthetic Human Body System, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan
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Department of Synthetic Human Body System, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan
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Department of Synthetic Human Body System, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan
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