Understanding excipient interactions unlocks untapped potential of RNA-lipid nanoparticles in dry powder formulations for local pulmonary delivery
Year: 2025
Type: article
Language: en
Topic: Inhalation and Respiratory Drug Delivery
Authors and affiliations:
raw_author_name: Nora Martini
raw_affiliation_strings: Department of Pharmacy, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany
raw_author_name: Leonie Deßloch
raw_affiliation_strings: Department of Pharmacy, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany; RNhale GmbH, Am Klopferspitz 19, 82152 Planegg, Germany
raw_author_name: Taras Sych
raw_affiliation_strings: Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
raw_author_name: Otto Berninghausen
raw_affiliation_strings: Gene Center and Department of Biochemistry, University of Munich, Munich 81377, Germany
raw_author_name: J. Merl-Pham
raw_affiliation_strings: Metabolomics and Proteomics Core, Helmholtz Zentrum Munich, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany
raw_author_name: Sjoerd Dijkstra
raw_affiliation_strings: Department of Pharmacy, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany
raw_author_name: Simone P. Carneiro
raw_affiliation_strings: Department of Pharmacy, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany; Center for NanoScience (CeNS), Ludwig-Maximilians-Universität München, Munich, Germany; Pharmaceutical Engineering and Technology Research Scientists (PETRS), Germany
raw_author_name: Marion Frankenberger
raw_affiliation_strings: Institute of Lung Health and Immunity (LHI) with CPC-M bioArchive, Comprehensive Pneumology Center (CPC-M), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany
raw_author_name: Roland Beckmann
raw_affiliation_strings: Gene Center and Department of Biochemistry, University of Munich, Munich 81377, Germany
raw_author_name: Jürgen Behr
raw_affiliation_strings: Department of Medicine V, LMU University Hospital, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), Munich, Germany
raw_author_name: Gabriele Matschiner
raw_affiliation_strings: RNhale GmbH, Am Klopferspitz 19, 82152 Planegg, Germany
raw_author_name: Christine Schuberth-Wagner
raw_affiliation_strings: RNhale GmbH, Am Klopferspitz 19, 82152 Planegg, Germany
raw_author_name: A. Önder Yildirim
raw_affiliation_strings: Institute of Lung Health and Immunity (LHI) with CPC-M bioArchive, Comprehensive Pneumology Center (CPC-M), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany; Institute of Experimental Pneumology, Ludwig-Maximilians University (LMU), Munich, Germany
raw_author_name: David C. Jürgens
raw_affiliation_strings: Department of Pharmacy, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany; RNhale GmbH, Am Klopferspitz 19, 82152 Planegg, Germany; Center for NanoScience (CeNS), Ludwig-Maximilians-Universität München, Munich, Germany
raw_author_name: Erdinc Sezgin
raw_affiliation_strings: Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
raw_author_name: Olivia M. Merkel
raw_affiliation_strings: Department of Pharmacy, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany; RNhale GmbH, Am Klopferspitz 19, 82152 Planegg, Germany; Center for NanoScience (CeNS), Ludwig-Maximilians-Universität München, Munich, Germany
raw_author_name: Benjamin Winkeljann
raw_affiliation_strings: Department of Pharmacy, Comprehensive Pneumology Center (CPC-M), Ludwig-Maximilians-Universität München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany; RNhale GmbH, Am Klopferspitz 19, 82152 Planegg, Germany; Center for NanoScience (CeNS), Ludwig-Maximilians-Universität München, Munich, Germany; Pharmaceutical Engineering and Technology Research Scientists (PETRS), Germany. Electronic address: benjamin.winkeljann@cup.lmu.de