Proteasome stress activates YAP/TAZ through the RAP2–MAP4Ks–LATS1/2 pathway and its therapeutic implications in solid tumors
Year: 2025
Type: article
Language: en
Topic: Hippo pathway signaling and YAP/TAZ
Authors and affiliations:
raw_author_name: Xin Wang
raw_affiliation_strings: Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University
Department of General Surgery, Zhongshan Hospital, Fudan University
Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
raw_author_name: Yuan Gu
raw_affiliation_strings: Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University
Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
raw_author_name: Zhenxing Zhong
raw_affiliation_strings: Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
raw_author_name: Pengcheng Yu
raw_affiliation_strings: Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
raw_author_name: Wenshuai Liu
raw_affiliation_strings: Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University
Department of General Surgery, Zhongshan Hospital, Fudan University
Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
raw_author_name: Rui Zhu
raw_affiliation_strings: Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
raw_author_name: Yu Wang
raw_affiliation_strings: Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
raw_author_name: Zhaocai Zhou
raw_affiliation_strings: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University
State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China
raw_author_name: Yihong Sun
raw_affiliation_strings: Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University
Department of General Surgery, Zhongshan Hospital, Fudan University
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
raw_author_name: Xuefei Wang
raw_affiliation_strings: Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University
Department of General Surgery, Zhongshan Hospital, Fudan University
Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
raw_author_name: Fa-Xing Yu
raw_affiliation_strings: Institute of Pediatrics, Children’s Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China