Controlled Self-Immolative Release of β-Lapachone via an Optimized <i>para</i> -Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy
Year: 2025
Type: article
Language: en
Topic: Bioactive Compounds and Antitumor Agents
Authors and affiliations:
raw_author_name: Julie B. Becher
raw_affiliation_strings: University of Cambridge
Yusuf Hamied Department of Chemistry
raw_author_name: Nisita Dutta
raw_affiliation_strings: Laboratory of Molecular Biology, National Cancer Institute
Medical Scientist Training Program
National Institutes of Health
University of Cambridge
University of Maryland School of Medicine
Yusuf Hamied Department of Chemistry
Medical Scientist Training Program, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K
raw_author_name: Claudio D. Navo
raw_affiliation_strings: Basque Research and Technology Alliance (BRTA)
Center for Cooperative Research in Biosciences (CIC bioGUNE)
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio 48160, Spain
raw_author_name: Lavinia Dunsmore
raw_affiliation_strings: University of Cambridge
Yusuf Hamied Department of Chemistry
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K
raw_author_name: Roman Misteli
raw_affiliation_strings: University of Cambridge
Yusuf Hamied Department of Chemistry
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K
raw_author_name: Enrique Gil de Montes
raw_affiliation_strings: University of Cambridge
Yusuf Hamied Department of Chemistry
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K
raw_author_name: Grant G. Simpson
raw_affiliation_strings: University of Cambridge
Yusuf Hamied Department of Chemistry
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K
raw_author_name: Christine C. Alewine
raw_affiliation_strings: Laboratory of Molecular Biology, National Cancer Institute
National Institutes of Health
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States
raw_author_name: Gonzalo Jiménez-Osés
raw_affiliation_strings: Basque Research and Technology Alliance (BRTA)
Center for Cooperative Research in Biosciences (CIC bioGUNE)
Ikerbasque, Basque Foundation for Science
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio 48160, Spain
Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain
raw_author_name: Gonçalo J. L. Bernardes
raw_affiliation_strings: Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO)
University of Cambridge
Yusuf Hamied Department of Chemistry
Translational Chemical Biology Group, Spanish National Cancer Research Centre 26 (CNIO), Madrid 28029, Spain
Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K