Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support
Year: 2025
Type: article
Language: en
Topic: Telomeres, Telomerase, and Senescence
Authors and affiliations:
raw_author_name: Laura Caceres-Palomo
raw_affiliation_strings: Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain
raw_author_name: Elisabeth Sanchez-Mejias
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain
raw_author_name: Laura Trujillo-Estrada
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain
raw_author_name: Juan Jose Perez-Moreno
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Departamento of Biologia Celular, Facultad de Biologia, Universidad de Sevilla, Sevilla, Spain
Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocio, CSIC/Universidad de Sevilla, Sevilla, 41013, Spain
raw_author_name: Elba Lopez-Oliva
raw_affiliation_strings: Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain
raw_author_name: Tau En Lim
raw_affiliation_strings: Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, 92697, USA
raw_author_name: Leah DeFlitch
raw_affiliation_strings: Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA
Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA
raw_author_name: Serena H. Chang
raw_affiliation_strings: Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA
Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA
raw_author_name: Lucas Kampman
raw_affiliation_strings: Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA
Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA
Present address: Basic Sciences Division and Computational Biology Program and Molecular and Cellular Biology Graduate Program, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA
raw_author_name: M. Ryan Corces
raw_affiliation_strings: Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA
Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA
raw_author_name: Mathew Blurton-Jones
raw_affiliation_strings: Department of Neurobiology & Behavior, University of California, Irvine, CA, 92697, USA
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, 92697, USA
raw_author_name: Ines Moreno-Gonzalez
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain
raw_author_name: Alberto Pascual
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocio, CSIC/Universidad de Sevilla, Sevilla, 41013, Spain
raw_author_name: Javier Vitorica
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Dpto. Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, 41012, Spain
Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocio, CSIC/Universidad de Sevilla, Sevilla, 41013, Spain
raw_author_name: Juan Antonio Garcia-Leon
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. jgarleon@uma.es
Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain. jgarleon@uma.es
raw_author_name: Antonia Gutierrez
raw_affiliation_strings: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. agutierrez@uma.es
Dpto. Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA-Plataforma Bionand, Facultad de Ciencias, Universidad de Malaga, Malaga, 29071, Spain. agutierrez@uma.es