Modeling immune lineage co-development in human pluripotent stem cell-derived liver organoids
Year: 2025
Type: article
Language: en
Topic: Pluripotent Stem Cells Research
Authors and affiliations:
raw_author_name: Milad Rezvani
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin Institute of Health, BIH Charité Clinician Scientist Program, 10178 Berlin, Germany; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Der Simulierte Mensch (Si-M), Joint research center of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Amrumer Str. 33, 13353 Berlin, Germany. Electronic address: Milad.Rezvani@charite.de
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT)Augustenburger Platz 1, 13353 Berlin, Germany; Berlin Institute of Health, BIH Charité Clinician Scientist Program, 10178 Berlin, Germany; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Der Simulierte Mensch (Si-M), Joint research center of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Amrumer Str. 33, 13353 Berlin. Electronic address: Milad.Rezvani@charite.de
raw_author_name: Susanna Quach
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
raw_author_name: Kyle Lewis
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Norikazu Saiki
raw_affiliation_strings: Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), Yushima, Bunkyo-ku, Tokyo, Japan; Organoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan
raw_author_name: Chuqing Xue
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
raw_author_name: Masaki Kimura
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Kentaro Iwasawa
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Julian Weihs
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
raw_author_name: Tahlil Elzobair
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Hasan Al Reza
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Yuqi Cai
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: RanRan Zhang
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Yuka Milton
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Praneet Chaturvedi
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Konrad Thorner
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Ramesh C. Nayak
raw_affiliation_strings: Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
raw_author_name: Jorge Munera
raw_affiliation_strings: Medical University of South Carolina, College of Medicine, Charleston, SC 29425, USA
Medical University of South Carolina, College of Medicine, Charleston, SC 29425
raw_author_name: Phillip Kramer
raw_affiliation_strings: Center for Stem Cell Research, Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Brian R. Davis
raw_affiliation_strings: Center for Stem Cell Research, Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Appakalai N. Balamurugan
raw_affiliation_strings: Wendy Novak Diabetes Institute, Norton Children's Research Institute, Norton Healthcare, Division of Endocrinology, Department of Pediatrics, Pediatric Research Institute, University of Louisville, Louisville, KY, 40202, USA
Clinical Islet Cell Laboratory, Center for Clinical and Translational Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH
raw_author_name: Yeni Ait Ahmed
raw_affiliation_strings: Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
raw_author_name: Marcel Finke
raw_affiliation_strings: Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany, Augustenburger Platz 1, 13353 Berlin, Germany
Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT)Augustenburger Platz 1, 13353 Berlin, Germany
raw_author_name: Rose Yinghan Behncke
raw_affiliation_strings: Institute of Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
raw_author_name: Adrien Guillot
raw_affiliation_strings: Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
raw_author_name: René Hägerling
raw_affiliation_strings: Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany, Augustenburger Platz 1, 13353 Berlin, Germany; Institute of Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany
Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT)Augustenburger Platz 1, 13353 Berlin, Germany; Institute of Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany
raw_author_name: Julia K. Polansky
raw_affiliation_strings: Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany, Augustenburger Platz 1, 13353 Berlin, Germany; German Rheumatism Research Center (DRFZ), Berlin, Germany
Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT)Augustenburger Platz 1, 13353 Berlin, Germany; German Rheumatism Research Center (DRFZ), Berlin, Germany
raw_author_name: Philip Bufler
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Pediatric Gastroenterology, Nephrology and Metabolic Medicine, Augustenburger Platz 1, 13353 Berlin, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany
raw_author_name: Jose A. Cancelas
raw_affiliation_strings: Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Department of Medicine, Harvard Medical School, Boston, USA; Experimental Hematology and Cancer Biology Research, Cincinnati Children's Hospital Medical Center, USA; Connell and O'Reilly Families Cell Manipulation Core Facility, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Cell Manipulation Core Facility and Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215; Experimental Hematology and Cancer Biology Research, Cincinnati Children's Hospital Medical Center; Connell and O'Reilly Families Cell Manipulation Core Facility, Dana-Farber Cancer Institute, Boston, MA 02115, USA
raw_author_name: Aaron M. Zorn
raw_affiliation_strings: Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: James M. Wells
raw_affiliation_strings: Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
raw_author_name: Momoko Yoshimoto
raw_affiliation_strings: Western Michigan University Homer Stryker MD School of Medicine, Center for Immunology, Department of Investigative Medicine, USA
Western Michigan University Homer Stryker MD School of Medicine, Center for Immunology, Department of Investigative Medicine
raw_author_name: Takanori Takebe
raw_affiliation_strings: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), Yushima, Bunkyo-ku, Tokyo, Japan; Organoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan; Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Genome Biology, Graduate School of Medicine, The University of Osaka, Suita, Osaka 565-0871, Japan; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka, Suita, Osaka 565-0871, Japan. Electronic address: Takanori.Takebe@cchmc.org
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), Yushima, Bunkyo-ku, Tokyo, Japan; Organoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan; Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Genome Biology, Graduate School of Medicine, The University of Osaka, Suita, Osaka 565-0871, Japan; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka , Suita, Osaka 565-0871, Japan. Electronic address: Takanori.Takebe@cchmc.org