Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation
Year: 2025
Type: article
Language: en
Topic: Pancreatic function and diabetes
Authors and affiliations:
raw_author_name: Shiqian Chen
raw_affiliation_strings: Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK
raw_author_name: Carolina B. Lobato
raw_affiliation_strings: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Section of Endocrinology, Department of Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
raw_author_name: Carissa Wong
raw_affiliation_strings: Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK
raw_author_name: Yusman Manchanda
raw_affiliation_strings: Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK
raw_author_name: Katrina Viloria
raw_affiliation_strings: Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
raw_author_name: Iona Davies
raw_affiliation_strings: Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK
raw_author_name: Daniel B. Andersen
raw_affiliation_strings: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Julia Ast
raw_affiliation_strings: Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; Novo Nordisk Research Centre Oxford, Innovation Building, Oxford, UK
raw_author_name: Kyle W. Sloop
raw_affiliation_strings: Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
raw_author_name: David J. Hodson
raw_affiliation_strings: Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
raw_author_name: Johannes Broichhagen
raw_affiliation_strings: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany; Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany
raw_author_name: Steve Bloom
raw_affiliation_strings: Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK
raw_author_name: Jens J. Holst
raw_affiliation_strings: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Tricia Tan
raw_affiliation_strings: Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK
raw_author_name: Alejandra Tomas
raw_affiliation_strings: Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK. Electronic address: a.tomas-catala@imperial.ac.uk
raw_author_name: Ben Jones
raw_affiliation_strings: Section of Endocrinology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK. Electronic address: ben.jones@imperial.ac.uk