A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates with diverse phenotypic and genotypic resistance mechanisms
Year: 2025
Type: article
Language: en
Topic: Antibiotic Resistance in Bacteria
Authors and affiliations:
raw_author_name: Ramya Mahadevan
raw_affiliation_strings: Titus Family Department of Clinical Practice, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California
Titus Family Department of Clinical Practice, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA
raw_author_name: Estefany Garcia
raw_affiliation_strings: Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
raw_author_name: Rajnikant Sharma
raw_affiliation_strings: Titus Family Department of Clinical Practice, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California
Titus Family Department of Clinical Practice, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA
raw_author_name: Hongqiang Qiu
raw_affiliation_strings: College of Pharmacy, Fujian Medical University
Department of Pharmacy, Fujian Medical University Union Hospital
Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China
College of Pharmacy, Fujian Medical University, Fuzhou, People's Republic of China
raw_author_name: Ahmed Elsheikh
raw_affiliation_strings: Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
raw_author_name: Robert Parambi
raw_affiliation_strings: Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
raw_author_name: Cely Saad Abboud
raw_affiliation_strings: Instituto Dante Pazzanese de Cardiologia
raw_author_name: Fernando Pasteran
raw_affiliation_strings: Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas, Antimicrobial Service of the National Institute of Infectious Diseases (ANLIS Dr. Carlos G. Malbrán)
raw_author_name: Maria Soledad Ramirez
raw_affiliation_strings: Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton
Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA
raw_author_name: Keith S. Kaye
raw_affiliation_strings: Division of Allergy, Immunology and Infectious Diseases, Rutgers Robert Wood Johnson Medical School
Division of Allergy, Immunology and Infectious Diseases, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
raw_author_name: Robert A. Bonomo
raw_affiliation_strings: CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES)
Department of Medicine, Case Western Reserve University School of Medicine
Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine
Departments of Pharmacology, Biochemistry, Proteomics and Bioinformatics, Case Western Reserve University School of Medicine
Geriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Education and Clinical Center
Geriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Education and Clinical Center, Cleveland, Ohio, USA
CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA
Departments of Pharmacology, Biochemistry, Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
raw_author_name: Gauri G. Rao
raw_affiliation_strings: Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Titus Family Department of Clinical Practice, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California
Titus Family Department of Clinical Practice, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA
Division of Pharmaceutics and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA