Multi-Omics and Single-Cell Dissection of Exostosin Glycosyltransferases (EXT1/EXT2) Reveals Divergent Oncogenic Roles and Therapeutic Vulnerabilities in Gliomas
Year: 2025
Type: article
Language: en
Topic: Proteoglycans and glycosaminoglycans research
Authors and affiliations:
raw_author_name: Yi-Chun Chiang
raw_affiliation_strings: Department of Surgery, Division of Neurosurgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
raw_author_name: Chih-Yang Wang
raw_affiliation_strings: Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
raw_author_name: Neethu Palekkode
raw_affiliation_strings: Department of Biotechnology, Mother Teresa Women's University, Kodaikanal, Tamil Nadu, 624101, India
PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
raw_author_name: Shun-Fa Yang
raw_affiliation_strings: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
raw_author_name: Kai-Fu Chang
raw_affiliation_strings: Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan
Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
raw_author_name: Ching-Chung Ko
raw_affiliation_strings: Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan
Department of Medical Imaging, Chi-Mei Medical Center, Tainan710402, Taiwan
School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
raw_author_name: Chih-Hsuan Chang
raw_affiliation_strings: Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
raw_author_name: Hui-Ru Lin
raw_affiliation_strings: Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
raw_author_name: Chi-Jen Wu
raw_affiliation_strings: College of Nursing, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
raw_author_name: Yu-Cheng Ho
raw_affiliation_strings: School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
raw_author_name: Chih-Chun Lin
raw_affiliation_strings: Department of Physical Therapy, I-Shou University, Kaohsiung 824005, Taiwan
raw_author_name: Chien-Han Yuan
raw_affiliation_strings: Department of Otolaryngology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
Department of Otolaryngology, National Defense Medical University, Taipei 11490, Taiwan
Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
raw_author_name: Sachin Kumar
raw_affiliation_strings: Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh 173229, India
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
raw_author_name: Dahlak Daniel Solomon
raw_affiliation_strings: Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
Yogananda School of AI Computers and Data Sciences, Shoolini University, Solan 173229, India
raw_author_name: Juan Lorell Ngadio
raw_affiliation_strings: Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta Timur 13210, Indonesia
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
raw_author_name: Fitria Sari Wulandari
raw_affiliation_strings: Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
raw_author_name: Do Thi Minh Xuan
raw_affiliation_strings: Faculty of Pharmacy, Van Lang University, 69/68 Dang Thuy Tram Street, Binh Loi Trung Ward, Ho Chi Minh City, 70000, Vietnam
raw_author_name: Chung-Bao Hsieh
raw_affiliation_strings: Division of General Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114202, Taiwan
raw_author_name: Meng-Chi Yen
raw_affiliation_strings: Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
raw_author_name: I-Jeng Yeh
raw_affiliation_strings: Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
raw_author_name: Pi-Chan Ko
raw_affiliation_strings: Department of Neurosurgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan
raw_author_name: Chia-Lung Shih
raw_affiliation_strings: Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan
raw_author_name: Hoi-Bor Chan
raw_affiliation_strings: Department of Neurosurgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan
raw_author_name: Yung-Kuo Lee
raw_affiliation_strings: Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan
Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
School of Medicine, National Defense Medical University, Taipei 11490, Taiwan
raw_author_name: Ngoc Uyen Nhi Nguyen
raw_affiliation_strings: Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, Florida 33602, USA
Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida 33602, USA