Polysaccharides from Syzygium aromaticum binding to 3CLpro contain glycoproteins interacting with RdRp against SARS-CoV-2
Year: 2025
Type: article
Language: en
Topic: SARS-CoV-2 and COVID-19 Research
Authors and affiliations:
raw_author_name: Can Jin
raw_affiliation_strings: Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Zhongshan, Guangdong, China, 528400; Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China
raw_author_name: Bo Feng
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China
raw_author_name: Pengfei Dou
raw_affiliation_strings: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, PR China
raw_author_name: Yuan Zhou
raw_affiliation_strings: Guangzhou National Laboratory, Guangzhou, 510005, China
raw_author_name: Tingting Guo
raw_affiliation_strings: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, PR China
raw_author_name: Yuxuan Liu
raw_affiliation_strings: Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, 430030, Wuhan, China
raw_author_name: Yaqi Ding
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China
raw_author_name: Meixia Li
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China
raw_author_name: Xia Chen
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China
Guangzhou National Laboratory, Guangzhou, 510005, China. Electronic address: chen_xinwen@gzlab.ac.cn
raw_author_name: Zhenyun Du
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China
raw_author_name: Chunfan Huang
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu Province, 210029, China
raw_author_name: Xuan Li
raw_affiliation_strings: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China
raw_author_name: Xiaojuan Xu
raw_affiliation_strings: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China
raw_author_name: H. Eric Xu
raw_affiliation_strings: University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China
raw_author_name: Xinwen Chen
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China
Guangzhou National Laboratory, Guangzhou, 510005, China. Electronic address: chen_xinwen@gzlab.ac.cn
raw_author_name: Kaiping Wang
raw_affiliation_strings: Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, 430030, Wuhan, China. Electronic address: wkpzcq@163.com
raw_author_name: Yi Zang
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China. Electronic address: yzang@simm.ac.cn
raw_author_name: Jia Li
raw_affiliation_strings: Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China. Electronic address: jli@simm.ac.cn
raw_author_name: Kan Ding
raw_affiliation_strings: Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Zhongshan, Guangdong, China, 528400; Glycochemistry and Glycobiology Lab, Carbohydrate Drug Research Center, Key Laboratory of Receptor Research, National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Science, No.19A Yuquan Road, Beijing, 100049, PR China; College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu Province, 210029, China; Henan Polysaccharide Research Center, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan, China. Electronic address: dingkan@simm.ac.cn