Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in <i> <i>Enterococcus faecium</i> </i> Septicemic Peritonitis Mouse Model While Sparing the Microbiome
Year: 2025
Type: article
Language: en
Topic: Enzyme function and inhibition
Authors and affiliations:
raw_author_name: Nader S. Abutaleb
raw_affiliation_strings: Center for One Health Research
Department of Biomedical Sciences and Pathobiology
Virginia Polytechnic Institute and State University
Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States
raw_author_name: Katrina J. Holly
raw_affiliation_strings: Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy
Purdue University
Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
raw_author_name: Carolyn K. Metcalfe
raw_affiliation_strings: Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy
Purdue University
Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
raw_author_name: Ahmed A. Abouelkhair
raw_affiliation_strings: Center for One Health Research
Department of Biomedical Sciences and Pathobiology
Virginia Polytechnic Institute and State University
Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States
raw_author_name: Prabhakara R. Tharra
raw_affiliation_strings: Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy
Purdue University
Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
raw_author_name: Annadka Shrinidhi
raw_affiliation_strings: Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy
Purdue University
Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
raw_author_name: Abdallah S. Abdelsattar
raw_affiliation_strings: Center for One Health Research
Department of Biomedical Sciences and Pathobiology
Virginia Polytechnic Institute and State University
Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States
raw_author_name: Victoria Burgo
raw_affiliation_strings: Duchossois Family Institute
University of Chicago
Duchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States
raw_author_name: Glory Melotte
raw_affiliation_strings: Duchossois Family Institute
University of Chicago
Duchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States
raw_author_name: Tomi Akin-Olabiyi
raw_affiliation_strings: Duchossois Family Institute
University of Chicago
Duchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States
raw_author_name: Sean Knoblauch
raw_affiliation_strings: Duchossois Family Institute
University of Chicago
Duchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States
raw_author_name: Ramanujam Ramaswamy
raw_affiliation_strings: Duchossois Family Institute
University of Chicago
Duchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States
raw_author_name: Che Woodson
raw_affiliation_strings: Duchossois Family Institute
University of Chicago
Duchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States
raw_author_name: Venkatesh P. Thirumalaikumar
raw_affiliation_strings: Center for Plant Biology, Department of Botany and Plant Pathology
Purdue Proteomics Facility, Bindley Bioscience Center
Purdue University
Purdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47907, United States
Center for Plant Biology, Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907, United States
raw_author_name: J. Alejandra Rodriguez
raw_affiliation_strings: Department of Biological Sciences
Purdue University
Department of Biological Sciences, Purdue University, West Lafeyette, Indiana 47907, United States
raw_author_name: Franklin J. Yeo
raw_affiliation_strings: Department of Biological Sciences
Purdue University
Department of Biological Sciences, Purdue University, West Lafeyette, Indiana 47907, United States
raw_author_name: Olivia C. Snell
raw_affiliation_strings: Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy
Purdue University
Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
raw_author_name: Alessio Nocentini
raw_affiliation_strings: Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences
University of Florence
Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino 50122, Italy
raw_author_name: Anitha Sundararajan
raw_affiliation_strings: Duchossois Family Institute
University of Chicago
Duchossois Family Institute, University of Chicago, Chicago, Illinois 60637, United States
raw_author_name: Matthew R. Olson
raw_affiliation_strings: Department of Biological Sciences
Purdue University
Department of Biological Sciences, Purdue University, West Lafeyette, Indiana 47907, United States
raw_author_name: Claudiu T. Supuran
raw_affiliation_strings: Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences
University of Florence
Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino 50122, Italy
raw_author_name: Mohamed N. Seleem
raw_affiliation_strings: Center for One Health Research
Department of Biomedical Sciences and Pathobiology
Virginia Polytechnic Institute and State University
Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States
raw_author_name: Daniel P. Flaherty
raw_affiliation_strings: Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy
Purdue Institute for Drug Discovery
Purdue Institute of Inflammation, Immunology and Infectious Disease
Purdue University
Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States