A human CAGinSTEM platform for decoding HTT repeats’ somatic instability links CAG interruption to HD pathology in neurons
Year: 2025
Type: article
Language: en
Topic: Genetic Neurodegenerative Diseases
Authors and affiliations:
raw_author_name: Martina Zobel
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Gianluca Damaggio
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy; University of Naples Federico II, Naples, Italy
raw_author_name: Maria Lidia Mignogna
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Dario Besusso
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy. Electronic address: dario.besusso@unimi.it
raw_author_name: Davide Scalzo
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Andrea Cossu
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Camilla Trovesi
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Mariacristina Crosti
raw_affiliation_strings: Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Francesco Cortina
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Ilaria Campus
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Giulio Formenti
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Saveria Mazzara
raw_affiliation_strings: Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy; Department of Computing Sciences and Bocconi Institute for Data Science and Analytics (BIDSA), Bocconi University, Milan, Italy
raw_author_name: Francesco Gregoretti
raw_affiliation_strings: National Research Council, Institute for High Performance Computing and Networking, Naples 80131, Italy
raw_author_name: Laura Antonelli
raw_affiliation_strings: National Research Council, Institute for High Performance Computing and Networking, Naples 80131, Italy
raw_author_name: Gennaro Oliva
raw_affiliation_strings: National Research Council, Institute for High Performance Computing and Networking, Naples 80131, Italy; CSCS - Swiss National Supercomputing Centre, Via Trevano 131, Lugano 6900, Switzerland
raw_author_name: Chiara Zuccato
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Vincenza Colonna
raw_affiliation_strings: National Research Council, Institute of Genetics and Biophysics, Naples 80131, Italy; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA
raw_author_name: Paola Conforti
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Matteo Cereda
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Riccardo Lorenzo Rossi
raw_affiliation_strings: Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan 20139, Italy
raw_author_name: Simone Maestri
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Andrea Scolz
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Raffale Iennaco
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy
raw_author_name: Elena Cattaneo
raw_affiliation_strings: Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan, Milan 20122, Italy; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, Milan 20122, Italy. Electronic address: elena.cattaneo@unimi.it