Structure-guided screening identifies Tucatinib as dual inhibitor for MCT1/2
Year: 2025
Type: article
Language: en
Topic: Signaling Pathways in Disease
Authors and affiliations:
raw_author_name: Binghong Xu
raw_affiliation_strings: State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China. binghong_xu@tju.edu.cn
State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China
raw_author_name: Xiaoyu Zhou
raw_affiliation_strings: State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China
raw_author_name: Yuanyue Shan
raw_affiliation_strings: GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Hong Kong Institute of Science & Innovation, Guangzhou, Guangzhou, Guangdong, 510530, China
raw_author_name: Sai Shi
raw_affiliation_strings: Department of Medical and Pharmaceutical Informatics, Hebei Medical University, Shijiazhuang, 050017, China
State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China
raw_author_name: Jiachen Li
raw_affiliation_strings: State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China
raw_author_name: Qinqin Liang
raw_affiliation_strings: State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China
raw_author_name: Ziyu Wang
raw_affiliation_strings: State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China
raw_author_name: Mingfeng Zhang
raw_affiliation_strings: Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, 310000, China. zhangmingfeng@westlake.edu.cn
Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, 310000, China
raw_author_name: Yaxin Wang
raw_affiliation_strings: State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China. wangyaxin@tju.edu.cn
State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China
raw_author_name: Duanqing Pei
raw_affiliation_strings: Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, 310000, China. peiduanqing@westlake.edu.cn
Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, 310000, China
raw_author_name: Sheng Ye
raw_affiliation_strings: State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China. sye@tju.edu.cn
State Key Laboratory of Synthetic Biology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin, 300072, China