Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies
Year: 2025
Type: article
Language: en
Topic: Chemokine receptors and signaling
Authors and affiliations:
raw_author_name: Claudia V. Perez Almeria
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Omolade Otun
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
Institut de Génomique Fonctionnelle (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France
raw_author_name: Roman Schlimgen
raw_affiliation_strings: Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA
raw_author_name: Thomas D. Lamme
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Lotte Di Niro
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Caitrin Crudden
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Jan Paul Bebelman
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Noureldine Youssef
raw_affiliation_strings: Institute for Molecular Cell Biology, CMB - Center for Molecular Biomedicine, University Hospital Jena, Friedrich-Schiller-University Jena, Jena, Germany
raw_author_name: Lejla Musli
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Shawn Jenjak
raw_affiliation_strings: Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA
raw_author_name: Vladimir Bobkov
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Julia Drube
raw_affiliation_strings: Institute for Molecular Cell Biology, CMB - Center for Molecular Biomedicine, University Hospital Jena, Friedrich-Schiller-University Jena, Jena, Germany
raw_author_name: Carsten Hoffmann
raw_affiliation_strings: Institute for Molecular Cell Biology, CMB - Center for Molecular Biomedicine, University Hospital Jena, Friedrich-Schiller-University Jena, Jena, Germany
raw_author_name: Brian F. Volkman
raw_affiliation_strings: Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA
raw_author_name: Sébastien Granier
raw_affiliation_strings: Institut de Génomique Fonctionnelle (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France
raw_author_name: Cherine Bechara
raw_affiliation_strings: Institut Universitaire de France, Paris, France
Institut de Génomique Fonctionnelle (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France
raw_author_name: Marco Siderius
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Raimond Heukers
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
QVQ Holding BV, Utrecht, the Netherlands
raw_author_name: Christopher T. Schafer
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
raw_author_name: Martine J. Smit
raw_affiliation_strings: Amsterdam Institute for Molecular and Life Sciences (AIMMS), Department of Chemistry & Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands. mj.smit@vu.nl