Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors
Year: 2025
Type: article
Language: en
Topic: CAR-T cell therapy research
Authors and affiliations:
raw_author_name: Michael Launspach
raw_affiliation_strings: Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany. michael.launspach@charite.de
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. michael.launspach@charite.de
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany. michael.launspach@charite.de
German Cancer Consortium (DKTK), partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany. michael.launspach@charite.de
raw_author_name: Julia Macos
raw_affiliation_strings: Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Shoaib Afzal
raw_affiliation_strings: Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Janik Hohmann
raw_affiliation_strings: Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Marc L. Appis
raw_affiliation_strings: Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Maximilian Pilgram
raw_affiliation_strings: Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Stefanie Beez
raw_affiliation_strings: Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Emily Ohlendorf
raw_affiliation_strings: Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Casper F. T. van der Ven
raw_affiliation_strings: Cellbricks GmbH, Berlin, Germany
raw_author_name: Chahrazad Lachiheb
raw_affiliation_strings: Cellbricks GmbH, Berlin, Germany
raw_author_name: Karin Töws
raw_affiliation_strings: Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Lena Andersch
raw_affiliation_strings: Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Marvin Jens
raw_affiliation_strings: Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Felix Zirngibl
raw_affiliation_strings: Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Jonas Kath
raw_affiliation_strings: BIH Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
raw_author_name: Maria Stecklum
raw_affiliation_strings: EPO Berlin-Buch GmbH, Berlin, Germany
raw_author_name: Elias Rodriguez-Fos
raw_affiliation_strings: Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
Experimental and Clinical Research Center (ECRC) of the MDC and Charité - Universitätsmedizin Berlin, Berlin, Germany
raw_author_name: Kathleen Anders
raw_affiliation_strings: Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Dimitrios L. Wagner
raw_affiliation_strings: BIH Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany
Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA
Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
raw_author_name: Anton G. Henssen
raw_affiliation_strings: Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
Experimental and Clinical Research Center (ECRC) of the MDC and Charité - Universitätsmedizin Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
raw_author_name: Ralf Kühn
raw_affiliation_strings: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
raw_author_name: Angelika Eggert
raw_affiliation_strings: Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany
University Medicine Essen, Essen, Germany
raw_author_name: Annette Künkele
raw_affiliation_strings: Berlin Center for Advanced Therapies (BeCAT), Charité - Universitätsmedizin Berlin, Berlin, Germany
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Oncology and Haematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany