Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
Year: 2025
Type: article
Language: en
Topic: DNA and Nucleic Acid Chemistry
Authors and affiliations:
raw_author_name: Sabrina Pia Nuccio
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Enrico Cadoni
raw_affiliation_strings: Department of Organic and Macromolecular Chemistry - Organic and Biomimetic Chemistry Research Group (OBCR), Faculty of Sciences, Campus Sterre, Krijgslaan 281, Building S4, Gent, Belgium
Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Roxani Nikoloudaki
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Silvia Galli
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: An-Jie Ler
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Claudia Sanchez-Cabanillas
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, 123 Old Brompton Road, London, UK
raw_author_name: Thomas E. Maher
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Ella Fan
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Dilek Guneri
raw_affiliation_strings: UCL School of Pharmacy, 29-39 Brunswick Square, London, UK
raw_author_name: Gem Flint
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Minghui Zhu
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Ling Sum Liu
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK
raw_author_name: Christopher R. Fullenkamp
raw_affiliation_strings: Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA
raw_author_name: Zoë Waller
raw_affiliation_strings: UCL School of Pharmacy, 29-39 Brunswick Square, London, UK
raw_author_name: Luca Magnani
raw_affiliation_strings: Department of Oncology and Haemato-Oncology, Università degli Studi di Milano, Milan, Italy
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, 123 Old Brompton Road, London, UK
raw_author_name: John S. Schneekloth
raw_affiliation_strings: Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA
raw_author_name: Marco Di Antonio
raw_affiliation_strings: Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK. m.di-antonio@imperial.ac.uk
Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK. m.di-antonio@imperial.ac.uk
The Francis Crick Institute, 1 Midland Road, London, UK. m.di-antonio@imperial.ac.uk
The Francis Crick Institute, 1 Midland Road, London, UK