Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease
Year: 2025
Type: article
Language: en
Topic: Hepatitis C virus research
Authors and affiliations:
raw_author_name: Paul Rothhaar
raw_affiliation_strings: Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
raw_author_name: Tomke Arand
raw_affiliation_strings: Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
raw_author_name: Ha Gyu-Thomas Seong
raw_affiliation_strings: Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
German Center for Infection Research, partner site Heidelberg, Heidelberg, Germany
Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany
raw_author_name: Christian Heuss
raw_affiliation_strings: Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK
raw_author_name: Margaret Tulessin
raw_affiliation_strings: Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany
Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
raw_author_name: Zhiqing Wang
raw_affiliation_strings: Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
raw_author_name: Colin Förster
raw_affiliation_strings: Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
raw_author_name: Alina C. Schneider
raw_affiliation_strings: Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
raw_author_name: Jocelyn Quistrebert
raw_affiliation_strings: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
raw_author_name: Haiting Chai
raw_affiliation_strings: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA
Center for Vaccines and Immunity, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA
raw_author_name: Marvin Reineke
raw_affiliation_strings: Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
Department of Medicine II, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Louise Benning
raw_affiliation_strings: Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
Department of Medicine II, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Jonathan Honegger
raw_affiliation_strings: Center for Vaccines and Immunity, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA
Institute of Virology, Faculty of Medicine, University of Duesseldorf, Duesseldorf, Germany
raw_author_name: Maike Hofmann
raw_affiliation_strings: Department of Medicine II, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Imperial College London, London, UK
raw_author_name: Robert Thimme
raw_affiliation_strings: Department of Medicine II, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
University College London Medical School, London, UK
raw_author_name: Jörg Timm
raw_affiliation_strings: Institute of Virology, Faculty of Medicine, University of Duesseldorf, Duesseldorf, Germany
University College London Medical School, London, UK
raw_author_name: STOPHCV investigators
raw_affiliation_strings: Imperial College London, London, UK
raw_author_name: Graham S. Cooke
raw_affiliation_strings: Imperial College London, London, UK
University College London Medical School, London, UK
raw_author_name: Sarah Pett
raw_affiliation_strings: University College London Medical School, London, UK
Brighton and Sussex Medical School, Brighton, UK
raw_author_name: Leanne McCabe
raw_affiliation_strings: University College London Medical School, London, UK
Nottingham University Hospitals NHS Trust, Nottingham, UK
raw_author_name: Chris Jones
raw_affiliation_strings: Imperial College London, London, UK
John Radcliffe Hospital, Oxford, UK
raw_author_name: Richard Gilson
raw_affiliation_strings: University College London Medical School, London, UK
Glasgow Royal Infirmary, Glasgow, UK
raw_author_name: Sumita Verma
raw_affiliation_strings: Brighton and Sussex Medical School, Brighton, UK
University of Surrey, Guilford, UK
raw_author_name: Stephen D. Ryder
raw_affiliation_strings: Nottingham University Hospitals NHS Trust, Nottingham, UK
Royal Free Hampstead NHS Trust Hospital, London, UK
raw_author_name: Jane D. Collier
raw_affiliation_strings: John Radcliffe Hospital, Oxford, UK
Chelsea & Westminster NHS Trust, London, UK
raw_author_name: Stephen T. Barclay
raw_affiliation_strings: Glasgow Royal Infirmary, Glasgow, UK
Swansea Bay University Health Board, Swansea, UK
raw_author_name: Aftab Ala
raw_affiliation_strings: University of Surrey, Guilford, UK
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
raw_author_name: Sanjay Bhagani
raw_affiliation_strings: Royal Free Hampstead NHS Trust Hospital, London, UK
University Hospitals of Leicester NHS Trust, Leicester, UK
raw_author_name: Mark Nelson
raw_affiliation_strings: Chelsea & Westminster NHS Trust, London, UK
St George's Hospital, London, UK
raw_author_name: Chin Lye Ch’ng
raw_affiliation_strings: Swansea Bay University Health Board, Swansea, UK
Newcastle Upon Tyne Hospitals NHS Trust, Newcastle, UK
raw_author_name: Ben Stone
raw_affiliation_strings: Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Hepatitis C Trust, London, UK
raw_author_name: Martin Wiselka
raw_affiliation_strings: University Hospitals of Leicester NHS Trust, Leicester, UK
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
raw_author_name: Daniel Forton
raw_affiliation_strings: St George’s Hospital, London, UK
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
raw_author_name: Stuart McPherson
raw_affiliation_strings: Newcastle Upon Tyne Hospitals NHS Trust, Newcastle, UK
University College London Medical School, London, UK
raw_author_name: Rachel Halford
raw_affiliation_strings: Hepatitis C Trust, London, UK
University College London Medical School, London, UK
raw_author_name: Dung Nguyen
raw_affiliation_strings: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
John Radcliffe Hospital, Oxford, UK
raw_author_name: David Smith
raw_affiliation_strings: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
University College London Medical School, London, UK
raw_author_name: Emily Dennis
raw_affiliation_strings: University College London Medical School, London, UK
Department of Infectious Diseases Virology, University Hospital Heidelberg, Heidelberg, Germany
raw_author_name: Fleur Hudson
raw_affiliation_strings: University College London Medical School, London, UK
Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany
raw_author_name: Eleanor J. Barnes
raw_affiliation_strings: John Radcliffe Hospital, Oxford, UK
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
Département de médecine familiale, Université de Montréal, Montréal, QC, Canada
raw_author_name: Ann Sarah Walker
raw_affiliation_strings: University College London Medical School, London, UK
Faculty of Medicine, School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia
raw_author_name: Paul Schnitzler
raw_affiliation_strings: Department of Infectious Diseases Virology, University Hospital Heidelberg, Heidelberg, Germany
Faculty of Medicine, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
raw_author_name: Uta Merle
raw_affiliation_strings: Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany
Faculty of Medicine, School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia
raw_author_name: Naglaa H. Shoukry
raw_affiliation_strings: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada
Département de Médecine, Université de Montréal, Montréal, QC, Canada
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
raw_author_name: Julie Bruneau
raw_affiliation_strings: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada
Département de médecine familiale, Université de Montréal, Montréal, QC, Canada
Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany
raw_author_name: Chaturaka Rodrigo
raw_affiliation_strings: Faculty of Medicine, School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia
Faculty of Medicine, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
MRC-University of Glasgow Centre for Virus Research, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
raw_author_name: Andrew Lloyd
raw_affiliation_strings: Faculty of Medicine, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
Liver Unit, Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona, CIBEREHD, Barcelona, Spain
raw_author_name: Rowena A. Bull
raw_affiliation_strings: Faculty of Medicine, School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia
Faculty of Medicine, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
Liver Unit, Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona, CIBEREHD, Barcelona, Spain
raw_author_name: M. Azim Ansari
raw_affiliation_strings: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
German Center for Infection Research, partner site Heidelberg, Heidelberg, Germany
Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany
raw_author_name: Carolin Mogler
raw_affiliation_strings: Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany
raw_author_name: John McLauchlan
raw_affiliation_strings: MRC-University of Glasgow Centre for Virus Research, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
raw_author_name: Xavier Forns
raw_affiliation_strings: Liver Unit, Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona, CIBEREHD, Barcelona, Spain
raw_author_name: Sofía Pérez-del-Pulgar
raw_affiliation_strings: Liver Unit, Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona, CIBEREHD, Barcelona, Spain
raw_author_name: Volker Lohmann
raw_affiliation_strings: Department of Infectious Diseases, Molecular Virology, Section Virus-Host interactions, Heidelberg University, Heidelberg, Germany. Volker.lohmann@med.uni-heidelberg.de
German Center for Infection Research, partner site Heidelberg, Heidelberg, Germany. Volker.lohmann@med.uni-heidelberg.de