Targeting TNK2/ACK1 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in pancreatic cancer
Year: 2025
Type: article
Language: en
Topic: Pancreatic and Hepatic Oncology Research
Authors and affiliations:
raw_author_name: Chao Wu
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Weishuai Liu
raw_affiliation_strings: Department of Pain Management, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Xiangting Hu
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Yongjie Xie
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Shengnan Li
raw_affiliation_strings: Cancer Center, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China
raw_author_name: Xinyue Liu
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Zhaojun Sun
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Xiaoling Li
raw_affiliation_strings: Department of Oncology, Children's Hospital Affiliated to Chongqing Medical University, Chongqing, China
raw_author_name: Xin Yu
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Yudong Yuan
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Yiping Zou
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Ran An
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Yanan Chen
raw_affiliation_strings: School of Medicine, Nankai University, Tianjin, China
raw_author_name: Hailong Wang
raw_affiliation_strings: Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Yukuan Feng
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Song Gao
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Hongwei Wang
raw_affiliation_strings: Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Yifei Wang
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Nan Wang
raw_affiliation_strings: Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA
Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
raw_author_name: Chao Yang
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Jun Yu
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Peiqing Sun
raw_affiliation_strings: Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA. psun@wakehealth.edu
Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. psun@wakehealth.edu
Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA
raw_author_name: Chongbiao Huang
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China. chhuang@tmu.edu.cn
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. chhuang@tmu.edu.cn
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China. chhuang@tmu.edu.cn
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China. chhuang@tmu.edu.cn
Tianjin's Clinical Research Center for Cancer, Tianjin, China. chhuang@tmu.edu.cn
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Antao Chang
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China. changantao@tjmuch.com
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. changantao@tjmuch.com
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China. changantao@tjmuch.com
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China. changantao@tjmuch.com
Tianjin's Clinical Research Center for Cancer, Tianjin, China. changantao@tjmuch.com
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
raw_author_name: Jihui Hao
raw_affiliation_strings: National Clinical Research Center for Cancer, Tianjin, China. haojihui@tjmuch.com
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. haojihui@tjmuch.com
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China. haojihui@tjmuch.com
Tianjin Key Laboratory of Digestive Cancer, Tianjin, China. haojihui@tjmuch.com
Tianjin's Clinical Research Center for Cancer, Tianjin, China. haojihui@tjmuch.com
Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
State Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin, China