Targeting mTORC2-dependent AKT/FOXO1/RNF125 signaling exploits a therapeutic vulnerability in c-MET–activated and β-catenin–mutated hepatocellular carcinoma
Year: 2025
Type: article
Language: en
Topic: FOXO transcription factor regulation
Authors and affiliations:
raw_author_name: Xue Wang
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Yi Zhou
raw_affiliation_strings: Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Department of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
raw_author_name: Shu Zhang
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Department of Head and Neck Oncology, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Christine Farrar
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Xuemei Xie
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Jiaheng Li
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Sophia M. Zhang
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Department of Head and Neck Oncology, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Zheng Zhang
raw_affiliation_strings: Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China
Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Andrew Yonemura
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Jonathan Toshio Haynes
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Xuping Feng
raw_affiliation_strings: Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China
Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Runze Shang
raw_affiliation_strings: Department of General Surgery, Affiliated Strait Hospital of Huaqiao University, Huaqiao University, Quanzhou, China
raw_author_name: Zhong Xu
raw_affiliation_strings: Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China
Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases, Wuhan, China
raw_author_name: Yanhui Wu
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
raw_author_name: Yu Qiao
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Department of Medical Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
raw_author_name: Guofei Cui
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Weiting Liao
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Rong Li
raw_affiliation_strings: Department of Anesthesiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, Xi’an, Shaanxi, China
Department of Anesthesiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University, China
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Diego F. Calvisi
raw_affiliation_strings: Institute of Pathology, University of Regensburg, Regensburg, Germany
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Department of Head and Neck Oncology, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Shuxing Zhang
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Department of Head and Neck Oncology, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Meng Xu
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China
raw_author_name: Xin Chen
raw_affiliation_strings: Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
raw_author_name: Haichuan Wang
raw_affiliation_strings: Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China
Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China