Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex
Year: 2025
Type: article
Language: en
Topic: Telomeres, Telomerase, and Senescence
Authors and affiliations:
raw_author_name: Samantha L. Sanford
raw_affiliation_strings: UPMC Hillman Cancer Center, Pittsburgh, PA, USA
raw_author_name: Mareike Badstübner
raw_affiliation_strings: Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA
raw_author_name: Michael Gerber
raw_affiliation_strings: UPMC Hillman Cancer Center, Pittsburgh, PA, USA
raw_author_name: William Mannherz
raw_affiliation_strings: Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA
Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
raw_author_name: Noah Lampl
raw_affiliation_strings: Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
raw_author_name: Rachel Dannenberg
raw_affiliation_strings: Department of Chemistry, The Pennsylvania State University, University Park, PA, USA
raw_author_name: Angela Hinchie
raw_affiliation_strings: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA
raw_author_name: Matthew A. Schaich
raw_affiliation_strings: Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
UPMC Hillman Cancer Center, Pittsburgh, PA, USA
raw_author_name: Sua Myong
raw_affiliation_strings: Program in Cell, Molecular, Developmental Biology and Biophysics, Johns Hopkins University, Baltimore, MD, USA
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA
raw_author_name: Mark Hedglin
raw_affiliation_strings: Department of Chemistry, The Pennsylvania State University, University Park, PA, USA
raw_author_name: Suneet Agarwal
raw_affiliation_strings: Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA
Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
raw_author_name: Jonathan K. Alder
raw_affiliation_strings: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA
raw_author_name: Michael D. Stone
raw_affiliation_strings: Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA
RNA Center, University of California Santa Cruz, Santa Cruz, CA, USA
raw_author_name: Patricia L. Opresko
raw_affiliation_strings: Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA. plo4@pitt.edu
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. plo4@pitt.edu
UPMC Hillman Cancer Center, Pittsburgh, PA, USA. plo4@pitt.edu
Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA