HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination With Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer
Year: 2025
Type: article
Language: en
Topic: HER2/EGFR in Cancer Research
Authors and affiliations:
raw_author_name: Veronique Dieras
raw_affiliation_strings: Medical Oncology Department, Centre Eugène Marquis, Rennes, France
raw_author_name: Giuseppe Curigliano
raw_affiliation_strings: Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy
European Institute of Oncology, IRCCS, Milano, Italy
raw_author_name: Miguel Martin
raw_affiliation_strings: Medical Oncology Service, Hospital General Universitario Gregorio Marañon, Universidad Complutense, CIBERONC, GEICAM, Madrid, Spain
raw_author_name: Florence Lerebours
raw_affiliation_strings: Institut Curie, Saint-Cloud, Paris, France
raw_author_name: Junji Tsurutani
raw_affiliation_strings: The Innovative Center of Translational Research and Clinical Science for Cancer Therapy, Showa Medical University Hospital, Tokyo, Japan
raw_author_name: Marie-France Savard
raw_affiliation_strings: Department of Medicine, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada
Department of Medicine, The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada
raw_author_name: Katarzyna J. Jerzak
raw_affiliation_strings: Department of Medicine, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada
Sunnybrook Odette Cancer Centre, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
raw_author_name: Xichun Hu
raw_affiliation_strings: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
raw_author_name: Luciana Carla Martins de Aquino Pimentel
raw_affiliation_strings: Medical Oncology, Liga Norte-Rio Grandense Contra o Cancer, Natal, Brazil
Medical Oncology, Liga Norte-Rio Grandense Contra o Cancer, Brazil
raw_author_name: Ciara C. O'Sullivan
raw_affiliation_strings: Department of Medical Oncology, Mayo Clinic, Rochester, MN
Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA
raw_author_name: Eriko Tokunaga
raw_affiliation_strings: Department of Breast Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
raw_author_name: Alicia Okines
raw_affiliation_strings: Institute of Cancer Research, London, United Kingdom
Medical Oncology, The Royal Marsden NHS Foundation Trust, London, United Kingdom
Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK
Institute of Cancer Research, London, UK
raw_author_name: Chiun-Sheng Huang
raw_affiliation_strings: Breast Care Center, National Taiwan University Hospital, Taipei, Taiwan
raw_author_name: William Jacot
raw_affiliation_strings: Département d'Oncologie Médicale, Institut Regional du Cancer de Montpellier, Montpellier University, INSERM U1194, Montpellier, France
raw_author_name: Joohyuk Sohn
raw_affiliation_strings: Division of Medical Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea
raw_author_name: Eduardo Cronemberger Silva
raw_affiliation_strings: Medical Oncology, Centro Regional Integrado de Oncologia (CRIO), Fortaleza, Brazil
raw_author_name: Volkmar Mueller
raw_affiliation_strings: Department of Gynecology and University Breast Center, Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
raw_author_name: Shan Yang
raw_affiliation_strings: Biostatistics, Pfizer Inc, Bothell, WA
Biostatistics, Pfizer Inc, Bothell, WA, USA
raw_author_name: Giovanna Granata
raw_affiliation_strings: Oncology Late Stage Development, Pfizer AG, Zug, Switzerland
raw_author_name: Qi Shen
raw_affiliation_strings: Oncology, Research and Development, Pfizer Inc, Collegeville, PA
Oncology, Research and Development, Pfizer Inc, Collegeville, PA, USA
raw_author_name: Libero Santarpia
raw_affiliation_strings: Oncology, Research and Development, Pfizer AG, Zug, Switzerland
raw_author_name: Erika Hamilton
raw_affiliation_strings: Medical Oncology, Sarah Cannon Research Institute, Nashville, TN
Medical Oncology, Sarah Cannon Research Institute, Nashville, TN, USA
raw_author_name: on behalf of the HER2CLIMB-05 Investigators