Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity
Year: 2025
Type: article
Language: en
Topic: Bacterial Genetics and Biotechnology
Authors and affiliations:
raw_author_name: Xuzichao Li
raw_affiliation_strings: Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China
Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Qiuqiu He
raw_affiliation_strings: Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Yanan Liu
raw_affiliation_strings: Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Bin Liu
raw_affiliation_strings: Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Zhikun Liu
raw_affiliation_strings: Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Hong Chen
raw_affiliation_strings: Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Shuqin Zhang
raw_affiliation_strings: Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Jie Han
raw_affiliation_strings: Department of Anatomy, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Yingcan Liu
raw_affiliation_strings: Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Jie Yang
raw_affiliation_strings: Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Hang Yin
raw_affiliation_strings: Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
raw_author_name: Zhenxi Guo
raw_affiliation_strings: Cryo-EM platform, School of life Sciences, Peking University, Beijing, China
raw_author_name: Yong Wei
raw_affiliation_strings: Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China
raw_author_name: Zhiyong Yuan
raw_affiliation_strings: Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. zyuan@tmu.edu.cn
Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China
raw_author_name: Hongtao Zhu
raw_affiliation_strings: Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China. hongtao.zhu@iphy.ac.cn
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China
raw_author_name: Heng Zhang
raw_affiliation_strings: Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. zhangheng134@gmail.com
Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China. zhangheng134@gmail.com
Tianjin Medical University Cancer Institute and Hospital, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, National Clinical Research Center for Cancer, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. zhangheng134@gmail.com
Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China