Efficacy and Safety of Aficamten in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM
Year: 2025
Type: article
Language: en
Topic: Cardiomyopathy and Myosin Studies
Authors and affiliations:
raw_author_name: Juan Pablo Kaski
raw_affiliation_strings: Centre for Paediatric Inherited and Rare Cardiovascular Disease, UCL Institute of Cardiovascular Science, University College London, United Kingdom (J.P.K.)
UCL Institute of Cardiovascular Science, University College London, United Kingdom (J.P.K.)
raw_author_name: Paul F. Kantor
raw_affiliation_strings: Division of Pediatric Cardiology, Children’s Hospital Los Angeles, University of Southern California (P.F.K.)
Children’s Hospital Los Angeles, University of Southern California (P.F.K.)
raw_author_name: Stephanie J. Nakano
raw_affiliation_strings: Division of Pediatric Cardiology, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora (S.J.N.)
Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora (S.J.N.)
raw_author_name: Iacopo Olivotto
raw_affiliation_strings: Cardiology Unit, Meyer Children’s Hospital, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Florence, Italy (I.O.)
Meyer Children’s Hospital, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Florence, Italy (I.O.)
raw_author_name: Mark W. Russell
raw_affiliation_strings: Division of Pediatric Cardiology, University of Michigan Medical School, Ann Arbor (M.W.R.)
University of Michigan Medical School, Ann Arbor (M.W.R.)
raw_author_name: Justin Godown
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Michael Chiu
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Polina German
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Stephen B. Heitner
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Daniel L. Jacoby
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Stuart Kupfer
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Justin Lutz
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Neha Maharao
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Fady I. Malik
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Chiara Melloni
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Paula F. Nieto Morales
raw_affiliation_strings: Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee (P.F.N.M.)
College of Medicine, Florida State University, Tallahassee (P.F.N.M.)
raw_author_name: Tyrell Simkins
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Jenny Wei
raw_affiliation_strings: Cytokinetics Inc, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
Cytokinetics, Incorporated, South San Francisco, CA (J.G., M.C., P.G., S.B.H., D.L.J., S.K., J.L., N.M., F.I.M., C.M., T.S., J.W.)
raw_author_name: Carolyn Y. Ho
raw_affiliation_strings: Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (C.Y.H.)
raw_author_name: on behalf of the CEDAR-HCM Investigators