Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis
Year: 2025
Type: article
Language: en
Topic: Cancer, Lipids, and Metabolism
Authors and affiliations:
raw_author_name: Yunfei Zhou
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Xinxin Yang
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
Precision Medical Center, Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China
raw_author_name: Jianwen Xu
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Yidi Wu
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Yin Fu
raw_affiliation_strings: Basic Medical College of Heilongjiang University of Chinese Medicine, Harbin, China
raw_author_name: Yihong Dong
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Xun Yang
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
Precision Medical Center, Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China
raw_author_name: Qiang Fu
raw_affiliation_strings: Basic Medical College of Heilongjiang University of Chinese Medicine, Harbin, China
raw_author_name: Chenxu Guo
raw_affiliation_strings: Precision Medical Center, Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China
raw_author_name: Yunjing Hou
raw_affiliation_strings: Precision Medical Center, Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China
raw_author_name: Shuyuan Chang
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Jun Yan
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Ju Ran
raw_affiliation_strings: Precision Medical Center, Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China
raw_author_name: Yumeng Wang
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Qingxin Zhang
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Tomii Ayaka
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China; Department of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Lei Yu
raw_affiliation_strings: Department of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin, China
raw_author_name: Feng Geng
raw_affiliation_strings: Key Laboratory of Molecular Oncology of Heilongjiang Province, Scientific Research Center, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address: gengfeng@hrbmu.edu.cn
raw_author_name: Liuyang Zhao
raw_affiliation_strings: Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing, China. Electronic address: liuyangzhao@cqmu.edu.cn
raw_author_name: Xiaoyang Hu
raw_affiliation_strings: Basic Medical College of Heilongjiang University of Chinese Medicine, Harbin, China. Electronic address: psa1981@126.com
raw_author_name: Shuijie Li
raw_affiliation_strings: State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, China; Heilongjiang Province Key Laboratory of Research on Molecular Targeted Anti-Tumor Drugs, Harbin, China. Electronic address: shuijie.li@hrbmu.edu.cn
raw_author_name: Hongxue Meng
raw_affiliation_strings: Precision Medical Center, Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address: menghongxue@hrbmu.edu.cn
raw_author_name: Dabin Liu
raw_affiliation_strings: NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China; Heilongjiang Provincial Key Laboratory of Panvascular Disease, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: liudb526@hrbmu.edu.cn