S-Nitrosylation of Pyruvate Kinase Isoform 2 Drives Cardiac Fibrosis by Promoting Mitochondrial Fission
Year: 2025
Type: article
Language: en
Topic: Cardiac Fibrosis and Remodeling
Authors and affiliations:
raw_author_name: Shanshan Luo
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Danyu Ye
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Yan Zhang
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Yan Zhang
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Yu Wang
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Miao Zhou
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Mengqi Lv
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Xiaoqian Wang
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Ke Zhong
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Yuxiao Zhang
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Yuxiao Zhang
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
raw_author_name: Lulu Hu
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
State Key Laboratory of Frigid Zone Cardiovascular Diseases (Z.Z., Y.J.), Harbin Medical University, Heilongjiang, PR China
raw_author_name: Shixiu Sun
raw_affiliation_strings: Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Key Laboratory of Myocardial Ischemia, Ministry of Education (B.Y.), Harbin Medical University, Heilongjiang, PR China
raw_author_name: Zhiren Zhang
raw_affiliation_strings: State Key Laboratory of Frigid Zone Cardiovascular Diseases (Z.Z., Y.J.), Harbin Medical University, Heilongjiang, PR China
Department of Nutrition and Food Hygiene, School of Public Health (C.S.), Harbin Medical University, Heilongjiang, PR China
raw_author_name: Bo Yu
raw_affiliation_strings: Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Key Laboratory of Myocardial Ischemia, Ministry of Education (B.Y.), Harbin Medical University, Heilongjiang, PR China
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University (X.K.), Nanjing Medical University, Nanjing, PR China
raw_author_name: Changhao Sun
raw_affiliation_strings: Department of Nutrition and Food Hygiene, School of Public Health (C.S.), Harbin Medical University, Heilongjiang, PR China
Department of Cardiology, The First Affiliated Hospital of Xiamen University, P.R. China (Z.H.)
raw_author_name: Xiangqing Kong
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Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital (X.C.), Nanjing Medical University, Nanjing, PR China
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Department of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University (Y.H.), Harbin Medical University, Heilongjiang, PR China
raw_author_name: Xin Chen
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Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
raw_author_name: Yi Han
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Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Nanjing, P.R. China (Y.J.)
State Key Laboratory of Frigid Zone Cardiovascular Diseases (Z.Z., Y.J.), Harbin Medical University, Heilongjiang, PR China
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Gusu School (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.), Nanjing Medical University, Nanjing, PR China
raw_author_name: Liping Xie
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Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
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Key Laboratory of Drug Targets and Translational Medicine for Cardio-Cerebrovascular Diseases, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Nanjing, PR China (S.L., D.Y., Y.Z., Y.W., M.Z., M.L., X.W., K.Z., Y.Z., L.H., S.S., L.X., Y.J.)
Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Nanjing, P.R. China (Y.J.)
State Key Laboratory of Frigid Zone Cardiovascular Diseases (Z.Z., Y.J.), Harbin Medical University, Heilongjiang, PR China