Sodium valproate drives propionylation-mediated epigenetic reprogramming to enhance mesothelin CAR-T cell therapy in solid tumors
Year: 2025
Type: article
Language: en
Topic: CAR-T cell therapy research
Authors and affiliations:
raw_author_name: Jiannan Chen
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: cjn.njnu@foxmail.com
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023. Electronic address: cjn.njnu@foxmail.com
raw_author_name: Wenying Li
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Shuai Wang
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Jiayi Li
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Lianfeng Zhao
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Xudong Ao
raw_affiliation_strings: Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China, 010000
raw_author_name: Wenyu Wang
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 310000
raw_author_name: Li Zhu
raw_affiliation_strings: Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China, 010000
raw_author_name: Haipeng Rao
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Shichu Xu
raw_affiliation_strings: Department of Dermatology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211166, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Mengru Wen
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Zhigang Hu
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Feiyan Pan
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Lingfeng He
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023
raw_author_name: Lili Gu
raw_affiliation_strings: Nanjing Calmhome Cell & Gene Engineering Institute Co., Ltd., Nanjing 210033, China
Nanjing Calmhome Cell & Gene Engineering Institute Co., Ltd., Nanjing, China, 210033
raw_author_name: Weijia Fang
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China; State Key Laboratory (SKL) of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310000, China
Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 310000; State Key Laboratory (SKL) of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, China, 310000
raw_author_name: Shengjing Xu
raw_affiliation_strings: Department of Dermatology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211166, China
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
Department of Dermatology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China, 211166
raw_author_name: Junqing Liang
raw_affiliation_strings: Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China. Electronic address: liang_junqing@126.com
Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China, 010000. Electronic address: cjn.njnu@foxmail.com
raw_author_name: Peng Zhao
raw_affiliation_strings: Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China; State Key Laboratory (SKL) of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310000, China. Electronic address: zhaop@zju.edu.cn
Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 310000; State Key Laboratory (SKL) of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, China, 310000. Electronic address: cjn.njnu@foxmail.com
raw_author_name: Haoyan Chen
raw_affiliation_strings: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China. Electronic address: haoyanchen@sjtu.edu.cn
Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China, 200001. Electronic address: cjn.njnu@foxmail.com
raw_author_name: Zhigang Guo
raw_affiliation_strings: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: 08278@njnu.edu.cn
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China, 210023. Electronic address: cjn.njnu@foxmail.com