The TDP-43I383V heterozygous mutation results in increased TDP-43 expression and altered neuronal activity in ALS patient-derived iPSC motor neurons
Year: 2025
Type: article
Language: en
Topic: Amyotrophic Lateral Sclerosis Research
Authors and affiliations:
raw_author_name: Ryo Chikuchi
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
raw_author_name: Yuta Kato
raw_affiliation_strings: Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan
raw_author_name: Aya Tomatsu
raw_affiliation_strings: Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan
raw_author_name: Shuto Nishisaki
raw_affiliation_strings: Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan
raw_author_name: Yu Kawakami
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
raw_author_name: Takashi Yoshimura
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
raw_author_name: Jiayi Li
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
raw_author_name: Yohei Iguchi
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
raw_author_name: Kazunari Onodera
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan; Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan
raw_author_name: Rina Hashimoto
raw_affiliation_strings: Department of Neurology, NHO Higashinagoya National Hospital, Nagoya 465-8620, Japan
Department of Neurology, NHO Higashinagoya National Hospital, Nagoya, 465-8620, Japan
raw_author_name: Ikuko Aiba
raw_affiliation_strings: Department of Neurology, NHO Higashinagoya National Hospital, Nagoya 465-8620, Japan
Department of Neurology, NHO Higashinagoya National Hospital, Nagoya, 465-8620, Japan
raw_author_name: Ryoichi Nakamura
raw_affiliation_strings: Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan; Division of ALS Research, Aichi Medical University School of Medicine, Aichi 480-1195, Japan
Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan; Division of ALS Research, Aichi Medical University, Aichi, 480-1195, Japan
raw_author_name: Genki Tohnai
raw_affiliation_strings: Division of ALS Research, Aichi Medical University School of Medicine, Aichi 480-1195, Japan
Division of ALS Research, Aichi Medical University, Aichi, 480-1195, Japan
raw_author_name: Naoki Atsuta
raw_affiliation_strings: Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan; Division of ALS Research, Aichi Medical University School of Medicine, Aichi 480-1195, Japan
Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan; Division of ALS Research, Aichi Medical University, Aichi, 480-1195, Japan
raw_author_name: Gen Sobue
raw_affiliation_strings: Division of ALS Research, Aichi Medical University School of Medicine, Aichi 480-1195, Japan; Aichi Medical University, Aichi 480-1195, Japan
Division of ALS Research, Aichi Medical University, Aichi, 480-1195, Japan; Aichi Medical University, Aichi, 480-1195, Japan
raw_author_name: Yohei Okada
raw_affiliation_strings: Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan
Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan
raw_author_name: Masahisa Katsuno
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
raw_author_name: Satoshi Yokoi
raw_affiliation_strings: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan. Electronic address: yokoi.satoshi.d8@f.mail.nagoya-u.ac.jp
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan; Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan. Electronic address: yokoi.satoshi.d8@f.mail.nagoya-u.ac.jp