Activity of Direct KRAS(G12C) Inhibitors in Preclinical Models of Pediatric Cancer
Year: 2025
Type: article
Language: en
Topic: Protein Kinase Regulation and GTPase Signaling
Authors and affiliations:
raw_author_name: Hannah E. Price
raw_affiliation_strings: 1Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI, Frederick, Maryland
National Cancer Institute, Frederick, MD, United States
raw_author_name: Stacey Stauffer
raw_affiliation_strings: 1Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI, Frederick, Maryland
National Cancer Institute, Frederick, MD, United States
raw_author_name: Hyun Lee
raw_affiliation_strings: 2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, Maryland
Uniformed Services University of the Health Sciences, United States
raw_author_name: Kristine A. Isanogle
raw_affiliation_strings: 3Animal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, Maryland
National Cancer Institute, United States
raw_author_name: Ying Wu
raw_affiliation_strings: 4Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, Maryland
National Cancer Institute, Bethesda, MD, United States
raw_author_name: Katie Powell
raw_affiliation_strings: 5RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland
Leidos Biomedical Research Inc., Frederick, United States
raw_author_name: Andrew Baker
raw_affiliation_strings: 6Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland
Johns Hopkins Medicine, United States
raw_author_name: Lucas Stauffer
raw_affiliation_strings: 1Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI, Frederick, Maryland
National Cancer Institute, Frederick, MD, United States
raw_author_name: Andrew J. Perciaccante
raw_affiliation_strings: 7Mass Spectrometry Resource, Laboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland
National Cancer Institute, Bethesda, MD, United States
raw_author_name: Connor P. Jewell
raw_affiliation_strings: 7Mass Spectrometry Resource, Laboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland
National Cancer Institute, Bethesda, MD, United States
raw_author_name: Edjay R. Hernandez
raw_affiliation_strings: 1Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI, Frederick, Maryland
National Cancer Institute, Frederick, MD, United States
raw_author_name: Ashwaq K. Aljabri
raw_affiliation_strings: 1Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI, Frederick, Maryland
National Cancer Institute, Frederick, MD, United States
raw_author_name: Patience Odeniyide
raw_affiliation_strings: 6Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland
Johns Hopkins University, baltimore, United States
raw_author_name: Christine A. Pratilas
raw_affiliation_strings: 6Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland
Johns Hopkins Medicine, Baltimore, MD, United States
raw_author_name: William Burgan
raw_affiliation_strings: 5RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland
Frederick National Laboratory for Cancer Research, Frederick, MD, United States
raw_author_name: Elijah F. Edmondson
raw_affiliation_strings: 8Molecular Histopathology Laboratory, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, Maryland
Frederick National Laboratory for Cancer Research, Frederick, MD, United States
raw_author_name: Simone Difilippantonio
raw_affiliation_strings: 3Animal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, Maryland
Leidos Biomedical Research Inc., Frederick, MD, United States
raw_author_name: Robert L. Kortum
raw_affiliation_strings: 2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, Maryland
Uniformed Services University of the Health Sciences, Bethesda, MD, United States
raw_author_name: Jack F. Shern
raw_affiliation_strings: 9Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland
National Cancer Institute, Bethesda, MD, United States
raw_author_name: Lisa M. Jenkins
raw_affiliation_strings: 7Mass Spectrometry Resource, Laboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland
National Cancer Institute, Bethesda, MD, United States
raw_author_name: Kent L. Rossman
raw_affiliation_strings: 10Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
raw_author_name: Marielle E. Yohe
raw_affiliation_strings: 1Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI, Frederick, Maryland
9Pediatric Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland
National Cancer Institute, Frederick, MD, United States