In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation
Year: 2025
Type: article
Language: en
Topic: Neuroinflammation and Neurodegeneration Mechanisms
Authors and affiliations:
raw_author_name: Clara de la Rosa
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität Munich, Munich, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Arek Kendirli
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany. arek.kendirli@med.uni-muenchen.de
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany. arek.kendirli@med.uni-muenchen.de
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. arek.kendirli@med.uni-muenchen.de
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Seren Baygün
raw_affiliation_strings: Institute of Experimental Haematology, Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University Munich, Munich, Germany
raw_author_name: Franz Bauernschmitt
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Anna S. Thomann
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Ilgin Kisioglu
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Daniela Beckmann
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität Munich, Munich, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Yves Carpentier Solorio
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität Munich, Munich, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Veronika Pfaffenstaller
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität Munich, Munich, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Yi-Heng Tai
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Niel Mehraein
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Paula Sanchez
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Lena Spieth
raw_affiliation_strings: German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany
raw_author_name: Lisa Ann Gerdes
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany
raw_author_name: Eduardo Beltran
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Klaus Dornmair
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Mikael Simons
raw_affiliation_strings: German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany
Institute of Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany
raw_author_name: Anneli Peters
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany
raw_author_name: Marc Schmidt-Supprian
raw_affiliation_strings: Institute of Experimental Haematology, Center for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University Munich, Munich, Germany
raw_author_name: Martin Kerschensteiner
raw_affiliation_strings: Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany. martin.kerschensteiner@med.uni-muenchen.de
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany. martin.kerschensteiner@med.uni-muenchen.de
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. martin.kerschensteiner@med.uni-muenchen.de
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany
Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-Universität Munich, Martinsried, Germany