Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations
Year: 2025
Type: article
Language: en
Topic: Fibroblast Growth Factor Research
Authors and affiliations:
raw_author_name: Carla Tangermann
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Avantika Ghosh
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Martin Ziegler
raw_affiliation_strings: Division of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), Heidelberg, Germany and DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany
German Cancer Consortium (DKTK), DKFZ core center Heidelberg, Heidelberg, Germany
raw_author_name: Francesco Facchinetti
raw_affiliation_strings: Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France
raw_author_name: Jannis Stappenbeck
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Yagmur Oyku Carus Sahin
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Marisa Riester
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Luise Carmina Viardot
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Tobias Zundel
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Luc Friboulet
raw_affiliation_strings: Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France
raw_author_name: Antoine Hollebecque
raw_affiliation_strings: Département d'Innovation Thérapeutique (DITEP), Gustave Roussy, Villejuif, France
Département de Médecine Oncologique, Gustave Roussy, Villejuif, France
raw_author_name: José J. Naveja
raw_affiliation_strings: 3rd Medical Department and University Cancer Center, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
Institute of Molecular Biology (IMB) gGmbH, Mainz, Germany
raw_author_name: Angela Wanninger
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
raw_author_name: Maria Elena Hess
raw_affiliation_strings: Faculty of Biology, University of Freiburg, Freiburg, Germany
Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Institute of Medical Bioinformatics and Systems Medicine, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Tilman Brummer
raw_affiliation_strings: German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
Institute of Molecular Medicine and Cell Research (IMMZ), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Melanie Boerries
raw_affiliation_strings: German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Institute of Medical Bioinformatics and Systems Medicine, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Sonja Loges
raw_affiliation_strings: Division of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), Heidelberg, Germany and DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany
German Cancer Consortium (DKTK), DKFZ core center Heidelberg, Heidelberg, Germany
raw_author_name: Yohann Loriot
raw_affiliation_strings: Département d'Innovation Thérapeutique (DITEP), Gustave Roussy, Villejuif, France
Département de Médecine Oncologique, Gustave Roussy, Villejuif, France
Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France
raw_author_name: Anna L. Illert
raw_affiliation_strings: Department of Hematology and Medical Oncology, University Medical Center Göttingen (UMG), Göttingen, Germany
Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and Technical University Munich, Munich, Germany
Internal Medicine III, Hematology and Medical Oncology, School of Medicine, Technical University Munich, Munich, Germany
Department of Medicine I, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
raw_author_name: Sven Diederichs
raw_affiliation_strings: Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. s.diederichs@dkfz.de
German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany. s.diederichs@dkfz.de
Division of Cancer Research, Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany