ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer
Year: 2025
Type: article
Language: en
Topic: Lung Cancer Research Studies
Authors and affiliations:
raw_author_name: Lydia Meder
raw_affiliation_strings: Chair of Experimental Medicine 1, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. lydia.meder@fau.de
Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Universitätsklinikum Erlangen, Erlangen, Germany. lydia.meder@fau.de
raw_author_name: Charlotte I. Orschel
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany
raw_author_name: Cyrielle L. Bouchez
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany
raw_author_name: Rahil Gholamipoorfard
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany
raw_author_name: Claudia V. Orschel
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany
raw_author_name: David Stahl
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany
raw_author_name: Christoph Kreer
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany
Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
raw_author_name: Mirjam Koker
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
raw_author_name: Marieke Nill
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
Chair of Experimental Medicine 1, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
raw_author_name: Ilayda G. Kocak
raw_affiliation_strings: Chair of Experimental Medicine 1, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
raw_author_name: Ka-Won Noh
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
raw_author_name: Xinlei Zhao
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany
raw_author_name: Leon Ullrich
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany
Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany
German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany
raw_author_name: Björn Häupl
raw_affiliation_strings: Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany
Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany
German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, Frankfurt am Main, Germany
German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Josefine Jakob
raw_affiliation_strings: Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany
Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany
German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
Institute of Pathology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
raw_author_name: Marie-Lisa Eich
raw_affiliation_strings: Institute of Pathology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
raw_author_name: Alexandra Florin
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
Core Facility Experimental and Preclinical Imaging Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
raw_author_name: Holger Grüll
raw_affiliation_strings: Core Facility Experimental and Preclinical Imaging Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Diagnostic and Interventional Radiology, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
raw_author_name: Jürgen Wolf
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
raw_author_name: Filippo Beleggia
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
raw_author_name: Reinhard Büttner
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany
German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, Frankfurt am Main, Germany
Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany
German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Thomas Oellerich
raw_affiliation_strings: Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany
Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany
German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, Frankfurt am Main, Germany
German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany
raw_author_name: Florian Klein
raw_affiliation_strings: University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany
Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany
raw_author_name: Johannes Brägelmann
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany
Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, German Cancer Consortium (DKTK), Essen, Germany
raw_author_name: H. Christian Reinhardt
raw_affiliation_strings: Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, German Cancer Consortium (DKTK), Essen, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
raw_author_name: Nima Abedpour
raw_affiliation_strings: Cancer Research Center Cologne Essen (CCCE), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany. roland.ullrich@uk-koeln.de
raw_author_name: Roland T. Ullrich
raw_affiliation_strings: Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. roland.ullrich@uk-koeln.de
University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany. roland.ullrich@uk-koeln.de
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany. roland.ullrich@uk-koeln.de
University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany. roland.ullrich@uk-koeln.de