ZAR1 pathogenic variants disrupt maternal mRNA storage and cause oocyte maturation defects in humans
Year: 2025
Type: article
Language: en
Topic: RNA regulation and disease
Authors and affiliations:
raw_author_name: Xiu-Quan Liao
raw_affiliation_strings: Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China
GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China
raw_author_name: Shuai Zhao
raw_affiliation_strings: Department of Obstetrics and Gynecology, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, 250022, China
State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China
raw_author_name: Chang-Long Zhang
raw_affiliation_strings: Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China
State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China
raw_author_name: Yan Zhu
raw_affiliation_strings: Medical Experimental Center, Guangdong Second Provincial General Hospital, Guangzhou, China
raw_author_name: Jun Wen
raw_affiliation_strings: GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China
raw_author_name: Yang Wang
raw_affiliation_strings: MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University, Hangzhou, China
raw_author_name: Shao-Yuan Liu
raw_affiliation_strings: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China
GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China
raw_author_name: Wei Su
raw_affiliation_strings: State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China
raw_author_name: Jiang-Tao Zhang
raw_affiliation_strings: State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China
raw_author_name: Qiong-Wen Lu
raw_affiliation_strings: School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China
raw_author_name: Fei Gong
raw_affiliation_strings: Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China
raw_author_name: Ge Lin
raw_affiliation_strings: Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China
raw_author_name: Heng-Yu Fan
raw_affiliation_strings: MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University, Hangzhou, China. hyfan@zju.edu.cn
MOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University, Hangzhou, China
raw_author_name: Wei Zheng
raw_affiliation_strings: Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China. ustczw@163.com
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China. ustczw@163.com
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China
raw_author_name: Han Zhao
raw_affiliation_strings: Department of Obstetrics and Gynecology, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, 250022, China. hanzh80@sdu.edu.cn
Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China. hanzh80@sdu.edu.cn
State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. hanzh80@sdu.edu.cn
State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Center for Reproductive Medicine,Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China
Department of Obstetrics and Gynecology, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, 250022, China
raw_author_name: Qian-Qian Sha
raw_affiliation_strings: Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China. shaqianqian@zju.edu.cn
GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China. shaqianqian@zju.edu.cn
GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China
Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China