Atom-level enzyme active site scaffolding using RFdiffusion2
Year: 2025
Type: article
Language: en
Topic: Protein Structure and Dynamics
Authors and affiliations:
raw_author_name: Woody Ahern
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA
raw_author_name: Jason Yim
raw_affiliation_strings: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Doug Tischer
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Saman Salike
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Seth M. Woodbury
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Donghyo Kim
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Indrek Kalvet
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Yakov Kipnis
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Brian Coventry
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Han Raut Altae-Tran
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Magnus S. Bauer
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA
Institute for Protein Design, University of Washington, Seattle, WA, USA
raw_author_name: Regina Barzilay
raw_affiliation_strings: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Tommi S. Jaakkola
raw_affiliation_strings: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Rohith Krishna
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA. rohith@uw.edu
Institute for Protein Design, University of Washington, Seattle, WA, USA. rohith@uw.edu
Department of Biochemistry, University of Washington, Seattle, WA, USA
raw_author_name: David Baker
raw_affiliation_strings: Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu
Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA