Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models
Year: 2025
Type: article
Language: en
Topic: Neuroblastoma Research and Treatments
Authors and affiliations:
raw_author_name: Melanie Schoof
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Mildred Scheel Cancer Career Centre HaTriCS4, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Tuyu Zheng
raw_affiliation_strings: Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA
Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Martin Sill
raw_affiliation_strings: Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Roland Imle
raw_affiliation_strings: Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
raw_author_name: Alessia Cais
raw_affiliation_strings: Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Lea Altendorf
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Alicia Fürst
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Nina Hofmann
raw_affiliation_strings: Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Kati Ernst
raw_affiliation_strings: Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
raw_author_name: Dominik Vonficht
raw_affiliation_strings: Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany
raw_author_name: Kenneth Chun-Ho Chan
raw_affiliation_strings: Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Tim Holland-Letz
raw_affiliation_strings: Department of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Andreas Postlmayr
raw_affiliation_strings: Translational Brain Tumor Research Group, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland
raw_author_name: Ryo Shiraishi
raw_affiliation_strings: Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan
raw_author_name: Wanchen Wang
raw_affiliation_strings: Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan
raw_author_name: Alaide Morcavallo
raw_affiliation_strings: Division of Clinical Studies, The Institute of Cancer Research, London, UK
raw_author_name: Michael Spohn
raw_affiliation_strings: Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Carolin Göbel
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Judith Niesen
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Mildred Scheel Cancer Career Centre HaTriCS4, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Levke-Sophie Peter
raw_affiliation_strings: Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Franck Bourdeaut
raw_affiliation_strings: SIREDO Pediatric Oncology Center, Institut Curie, Paris-Science Lettres University, Paris, France
raw_author_name: Zhi-Yan Han
raw_affiliation_strings: SIREDO Pediatric Oncology Center, Institut Curie, Paris-Science Lettres University, Paris, France
raw_author_name: Yanxin Pei
raw_affiliation_strings: Center for Cancer and Immunology, Brain Tumor Institute, Children's National Health System, Washington, DC, USA
raw_author_name: Najiba Murad
raw_affiliation_strings: Center for Cancer and Immunology, Brain Tumor Institute, Children's National Health System, Washington, DC, USA
raw_author_name: Fredrik J. Swartling
raw_affiliation_strings: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
raw_author_name: Jessica Taylor
raw_affiliation_strings: Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK
raw_author_name: Monika Yadav
raw_affiliation_strings: Department of Pediatrics, Children's Mercy Research Institute (CMRI), Kansas City, MO, USA
raw_author_name: Garrett R. Gibson
raw_affiliation_strings: Department of Pediatrics, Children's Mercy Research Institute (CMRI), Kansas City, MO, USA
raw_author_name: Richard J. Gilbertson
raw_affiliation_strings: Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK
raw_author_name: Matthias Dottermusch
raw_affiliation_strings: Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
raw_author_name: Rajanya Roy
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany
raw_author_name: Kornelius Kerl
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany
raw_author_name: Rainer Glass
raw_affiliation_strings: Neurosurgical Research, Department of Neurosurgery, LMU University Hospital, LMU Munich, München, Germany
raw_author_name: Jiying Cheng
raw_affiliation_strings: Neurosurgical Research, Department of Neurosurgery, LMU University Hospital, LMU Munich, München, Germany
raw_author_name: Martin A. Horstmann
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Gerrit Wolters-Eisfeld
raw_affiliation_strings: Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Haotian Zhao
raw_affiliation_strings: Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA
raw_author_name: Dominik Sturm
raw_affiliation_strings: Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Viveka Nand Yadav
raw_affiliation_strings: Department of Cancer Biology, University of Kansas Cancer Center, Kansas City, KS, USA
Department of Pediatrics, Children's Mercy Research Institute (CMRI), Kansas City, MO, USA
Department of Pediatrics, University of Missouri Kansas City School of Medicine, Kansas City, MO, USA
raw_author_name: Louis Chesler
raw_affiliation_strings: Children and Young People's Unit, The Royal Marsden Hospital, London, UK
Paediatric Oncology Experimental Medicine Centre, The Institute of Cancer Research, London, UK
raw_author_name: Simon Haas
raw_affiliation_strings: Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Berlin Institute of Health (BIH) at Charité Universitätsmedizin Berlin, Berlin, Germany
raw_author_name: William A. Weiss
raw_affiliation_strings: Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA
raw_author_name: Paul A. Northcott
raw_affiliation_strings: Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA
raw_author_name: Lena M. Kutscher
raw_affiliation_strings: Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
raw_author_name: Ana Guerreiro Stucklin
raw_affiliation_strings: Division of Oncology, University Children's Hospital Zurich, Zurich, Switzerland
Translational Brain Tumor Research Group, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland
raw_author_name: Olivier Ayrault
raw_affiliation_strings: Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France
Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Orsay, France
raw_author_name: Julia E. Neumann
raw_affiliation_strings: Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
raw_author_name: Daisuke Kawauchi
raw_affiliation_strings: Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan
raw_author_name: David T. W. Jones
raw_affiliation_strings: Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Kristian Pajtler
raw_affiliation_strings: Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany
Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Ana Banito
raw_affiliation_strings: Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
Soft-Tissue Sarcoma Junior Research Group, DKFZ, Heidelberg, Germany
raw_author_name: Stefan M. Pfister
raw_affiliation_strings: Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Ulrich Schüller
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany
raw_author_name: Marc Zuckermann
raw_affiliation_strings: Division of Pediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. m.zuckermann@kitz-heidelberg.de
German Cancer Research Center (DKFZ), Heidelberg, Germany. m.zuckermann@kitz-heidelberg.de
National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. m.zuckermann@kitz-heidelberg.de