A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
Year: 2025
Type: article
Language: en
Topic: interferon and immune responses
Authors and affiliations:
raw_author_name: Jing Han
raw_affiliation_strings: School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; SXMU-Tsinghua, Taiyuan, China
raw_author_name: Shuhao Zhang
raw_affiliation_strings: State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China
raw_author_name: Yanfei Hou
raw_affiliation_strings: School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; SXMU-Tsinghua, Taiyuan, China
raw_author_name: Yi Wang
raw_affiliation_strings: School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; SXMU-Tsinghua, Taiyuan, China
raw_author_name: Zhengyin Zhang
raw_affiliation_strings: School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; SXMU-Tsinghua, Taiyuan, China
raw_author_name: Jiaming Yang
raw_affiliation_strings: School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; SXMU-Tsinghua, Taiyuan, China
raw_author_name: Yifang Xu
raw_affiliation_strings: School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; SXMU-Tsinghua, Taiyuan, China
raw_author_name: Zexu Peng
raw_affiliation_strings: Collaborative Innovation Center for Frontier Medicine, Shanxi Medical University, Taiyuan, Shanxi, China
raw_author_name: Hang Yin
raw_affiliation_strings: School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China
raw_author_name: Kehong Chen
raw_affiliation_strings: Department of Nephrology, Daping Hospital, Army Medical University, Chongqing Key Laboratory of Precision Diagnosis and Treatment for Kidney Diseases, Chongqing, China. Electronic address: kehong_chen@126.com
raw_author_name: Xiangyu Liu
raw_affiliation_strings: State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. Electronic address: liu_xy@mail.tsinghua.edu.cn
raw_author_name: Conggang Zhang
raw_affiliation_strings: School of Pharmaceutical Sciences, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; Collaborative Innovation Center for Frontier Medicine, Shanxi Medical University, Taiyuan, Shanxi, China; SXMU-Tsinghua, Taiyuan, China. Electronic address: cgzhang@tsinghua.edu.cn