Molecular and clinical stratification of astroblastomas: Three distinct fusion-defined groups informing risk-adapted treatment strategies
Year: 2025
Type: article
Language: en
Topic: Glioma Diagnosis and Treatment
Authors and affiliations:
raw_author_name: Aniello Federico
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Felix Schmitt-Hoffner
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Faculty of Biosciences, Heidelberg University , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Adriana Fonseca
raw_affiliation_strings: Brain Tumor Institute, Children’s National Hospital , Washington, District of Columbia, (Ad.F., Lan.W., R.J.P.)
raw_author_name: Neal Geisemeyer
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Katharina Bruckner
raw_affiliation_strings: Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna , Vienna,
raw_author_name: Monika Mauermann
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Martin Sill
raw_affiliation_strings: Department of Neuropathology, Heidelberg University Hospital , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Damian Stichel
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
raw_author_name: Dominik Sturm
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Ulrich Schüller
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf , Hamburg,
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf , Hamburg,
Research Institute Children’s Cancer Center Hamburg , Hamburg,
raw_author_name: Arnault Tauziede-Espariat
raw_affiliation_strings: Department of Neuropathology, GHU Paris Psychiatry and Neurosciences, Sainte-Anne Hospital , Paris,
raw_author_name: Pascale Varlet
raw_affiliation_strings: Department of Neuropathology, GHU Paris Psychiatry and Neurosciences, Sainte-Anne Hospital , Paris,
raw_author_name: David Capper
raw_affiliation_strings: Department of Neuropathology, Charité Universitätsmedizin Berlin , Berlin,
Department of Neuropathology, Heidelberg University Hospital , Heidelberg,
raw_author_name: Zied Abdullaev
raw_affiliation_strings: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland,
raw_author_name: Daniel Schrimpf
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
raw_author_name: Florian Selt
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Lane Williamson
raw_affiliation_strings: Brain Tumor Institute, Children’s National Hospital , Washington, District of Columbia, (Ad.F., Lan.W., R.J.P.)
raw_author_name: Andrew M Donson
raw_affiliation_strings: Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine , Aurora, Colorado,
raw_author_name: Manila Antonelli
raw_affiliation_strings: Department of Radiological, Oncological and Anatomic Pathology, Sapienza University , Rome,
IRCCS Istituto Neurologico Mediterraneo NEUROMED , Pozzilli,
raw_author_name: Evelina Miele
raw_affiliation_strings: Onco-Hematology, Cell Therapy, Gene Therapies, and Haemopoietic Transplant, Bambino Gesù Children’s Hospital, IRCCS , Rome,
raw_author_name: Matija Snuderl
raw_affiliation_strings: Department of Pathology, New York University School of Medicine , New York, New York,
raw_author_name: Sebastian Brandner
raw_affiliation_strings: Department of Neurodegeneration, Institute of Neurology, University College London , London,
raw_author_name: Maria Łastowska
raw_affiliation_strings: Department of Pathomorphology, Children’s Memorial Health Institute , Warsaw,
raw_author_name: Jasper van der Lugt
raw_affiliation_strings: Princess Máxima Center for Pediatric Oncology , Utrecht,
raw_author_name: Jens Bunt
raw_affiliation_strings: Princess Máxima Center for Pediatric Oncology , Utrecht,
raw_author_name: Christof Kramm
raw_affiliation_strings: Division of Pediatric Hematology and Oncology, University Medical Center Goettingen , Goettingen,
raw_author_name: Alexandra Kolenova
raw_affiliation_strings: Comenius University Department of Hematology and Oncology, , Bratislava, Slovakia (A.K.)
raw_author_name: Aditya Raghunathan
raw_affiliation_strings: Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, Minnesota,
raw_author_name: Yelena Wilson
raw_affiliation_strings: Department of Pathology, Akron Children’s Hospital , Akron, Ohio,
raw_author_name: Lauren Weintraub
raw_affiliation_strings: Pediatric Hematology/Oncology, Albany Medical Center , Albany, New York,
raw_author_name: Jordan R Hansford
raw_affiliation_strings: Children’s Cancer Centre, Royal Children’s Hospital; Murdoch Children’s Research Institute; Department of Pediatrics, University of Melbourne , Melbourne, Victoria,
Michael Rice Center for Haematology and Oncology, Women’s and Children’s Hospital , Adelaide, South Australia, (J.R.H.)
South Australia Health and Medical Research Institute , Adelaide, (J.R.H.)
South Australia Immunogenomics Cancer Institute, University of Adelaide , Adelaide, (J.R.H.)
raw_author_name: Sabine Spiegl-Kreinecker
raw_affiliation_strings: Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University , Linz, (S.S.-K.)
raw_author_name: Barbara Aistleitner
raw_affiliation_strings: Department of Pediatrics and Adolescent Medicine, Kepler University Hospital, Johannes Kepler University , Linz, (B.A.)
raw_author_name: Lorena Baroni
raw_affiliation_strings: Department of Hematology/Oncology, Hospital JP Garrahan , Buenos Aires,
raw_author_name: Michal Zapotocky
raw_affiliation_strings: Prague Brain Tumor Research Group, Second Faculty of Medicine, Charles University and University Hospital Motol , Prague,
raw_author_name: Vijay Ramaswamy
raw_affiliation_strings: Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children , Toronto,
raw_author_name: Andrey Korshunov
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Barbara Jones
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Mimi Kjaersgaard
raw_affiliation_strings: Department of Paediatrics and Adolescent Medicine, Children and Adolescents with Cancer and Hematological Diseases, Rigshospitalet , Copenhagen,
raw_author_name: Mariëtte E Kranendonk
raw_affiliation_strings: Princess Máxima Center for Pediatric Oncology , Utrecht,
raw_author_name: Christine Haberler
raw_affiliation_strings: Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna , Vienna,
raw_author_name: Roger J Packer
raw_affiliation_strings: Brain Tumor Institute, Children’s National Hospital , Washington, District of Columbia, (Ad.F., Lan.W., R.J.P.)
Center for Neuroscience and Behavioral Medicine, Children’s National Hospital , Washington, District of Columbia, (R.J.P.)
raw_author_name: Natalie Jäger
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Andreas von Deimling
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Felix Sahm
raw_affiliation_strings: Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Jan Koster
raw_affiliation_strings: Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam , Amsterdam,
raw_author_name: Kenneth Aldape
raw_affiliation_strings: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland,
raw_author_name: Stefan M Pfister
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
raw_author_name: Katja von Hoff
raw_affiliation_strings: Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin , , Berlin
Department of Paediatric and Adolescent Medicine, Aarhus University Hospital , Aarhus,
raw_author_name: Johannes Gojo
raw_affiliation_strings: Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna , Vienna,
raw_author_name: Marcel Kool
raw_affiliation_strings: Department of Pathomorphology, Children’s Memorial Health Institute , Warsaw,
Department of Pediatric Hematology and Oncology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT) , Heidelberg,
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg,
Hopp-Children’s Cancer Center Heidelberg (KiTZ) , Heidelberg,
University Medical Center Utrecht, Utrecht ­University , Utrecht,