Durvalumab with carboplatin/paclitaxel and bevacizumab followed by durvalumab and bevacizumab with or without olaparib maintenance in newly diagnosed non-BRCA-mutated advanced ovarian cancer
Year: 2025
Type: article
Language: en
Topic: PARP inhibition in cancer therapy
Authors and affiliations:
raw_author_name: P. Harter
raw_affiliation_strings: Department of Gynaecology & Gynaecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Phillips University, Marburg, Germany; Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Studiengruppe, Wiesbaden, Germany. Electronic address: P.Harter@kem-med.com
Department of Gynaecology & Gynaecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Phillips University, Marburg, and Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Studiengruppe, Germany. Electronic address: P.Harter@kem-med.com
raw_author_name: F. Trillsch
raw_affiliation_strings: Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Studiengruppe, Wiesbaden, Germany; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, and AGO Studiengruppe, Germany
raw_author_name: A. Okamoto
raw_affiliation_strings: Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan; Japanese Gynecologic Oncology Group (JGOG), Tokyo, Japan
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, and Japanese Gynecologic Oncology Group (JGOG), Japan
raw_author_name: A. Reuss
raw_affiliation_strings: Co-ordinating Center for Clinical Trials of the Philipps-University of Marburg, Marburg, Germany; European Network of Gynaecological Oncological Trial Groups (ENGOT), Berlin, Germany
Co-ordinating Center for Clinical Trials of the Philipps-University of Marburg, Marburg, and European Network of Gynaecological Oncological Trial groups (ENGOT), Germany
raw_author_name: J.-W. Kim
raw_affiliation_strings: Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, South Korea; Korean Gynecologic Oncology Group (KGOG), Seoul, South Korea
Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, and Korean Gynecologic Oncology Group (KGOG), South Korea
raw_author_name: M.J. Rubio-Pérez
raw_affiliation_strings: Reina Sofia University Hospital, Cordoba, Spain; Grupo Español de Investigación en Cáncer de Ovario (GEICO), Madrid, Spain
Reina Sofia University Hospital, Cordoba, and Grupo Español de Investigación en Cáncer de Ovario (GEICO), Spain
raw_author_name: M.A. Vardar
raw_affiliation_strings: Medical Faculty, Department of Obstetrics and Gynecology, University of Cukurova, Adana, Turkey; Department of Gynecologic Oncology, Balcalı Hospital, Adana, Turkey; Turkish Society of Gynecologic Oncology (TRSGO), Istanbul, Turkey
Medical Faculty, Department of Obstetrics and Gynecology, University of Cukurova, and Department of Gynecologic Oncology, Balcalı Hospital, Adana, and Turkish Society of Gynecologic Oncology (TRSGO), Turkey
raw_author_name: G. Scambia
raw_affiliation_strings: Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Multicenter Italian Trials in Ovarian Cancer and Gynecologic Malignancies (MITO), Rome, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, and Multicenter Italian Trials in Ovarian Cancer and Gynecologic Malignancies (MITO), Italy
raw_author_name: O. Trédan
raw_affiliation_strings: Centre Léon Bérard, Department of Medical Oncology, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens (GINECO), Paris, France
Centre Léon Bérard, Department of Medical Oncology, Centre de Recherche en Cancérologie de Lyon, Lyon, and Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens (GINECO), France
raw_author_name: G.-B. Nyvang
raw_affiliation_strings: Odense Universitetshospital, Odense, Denmark; Nordic Society of Gynecologic Oncology (NSGO), Copenhagen, Denmark
Odense Universitetshospital, Odense, and Nordic Society of Gynecologic Oncology (NSGO), Denmark
raw_author_name: N. Colombo
raw_affiliation_strings: University of Milan-Bicocca and Istituto Europeo di Oncologia IRCCS, Milan, Italy; Mario Negri Gynecologic Oncology Group (MANGO), Milan, Italy
University of Milan-Bicocca and Istituto Europeo di Oncologia IRCCS, Milan, and Mario Negri Gynecologic Oncology Group (MANGO), Italy
raw_author_name: M. Bidziński
raw_affiliation_strings: Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland; Polish Gynaecologic Oncology Group (PGOG), Warsaw, Poland
Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, and Polish Gynaecologic Oncology Group (PGOG), Poland
raw_author_name: C. Grimm
raw_affiliation_strings: Department of General Gynecology and Gynecologic Oncology, Comprehensive Cancer Center, Gynecologic Cancer Unit, Medical University of Vienna, Vienna, Austria; AGO-Austria, Vienna, Austria
Department of General Gynecology and Gynecologic Oncology, Comprehensive Cancer Center, Gynecologic Cancer Unit, Medical University of Vienna, and AGO-Austria, Austria
raw_author_name: S. Lheureux
raw_affiliation_strings: Princess Margaret Cancer Centre, Department of Medical Oncology, Toronto, Canada; Princess Margaret Consortium (PMHC), Toronto, Canada
Princess Margaret Cancer Centre, Department of Medical Oncology, Toronto, ON, and Princess Margaret Consoritum (PMHC), Canada
raw_author_name: E. Van Nieuwenhuysen
raw_affiliation_strings: UZ Leuven, Leuven, Belgium; Belgian Gynaecological Oncology Group (BGOG), Leuven, Belgium
UZ Leuven, Leuven, and Belgian Gynaecological Oncology Group (BGOG), Belgium
raw_author_name: F. Heitz
raw_affiliation_strings: Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Studiengruppe, Wiesbaden, Germany; Department of Gynecology & Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany; Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany
Department of Gynecology & Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, and AGO Studiengruppe, Germany
raw_author_name: R.M. Wenham
raw_affiliation_strings: Moffitt Cancer Center, Department of Gynecologic Oncology, Tampa, USA; Gynecologic Oncology Group Foundation (GOG-F), Philadelphia, USA
Moffitt Cancer Center, Department of Gynecologic Oncology, Tampa, and Gynecologic Oncology Group Foundation (GOG-F), USA
raw_author_name: S. Nishio
raw_affiliation_strings: Japanese Gynecologic Oncology Group (JGOG), Tokyo, Japan; Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Fukuoka, and JGOG, Japan
raw_author_name: M.C. Lim
raw_affiliation_strings: Korean Gynecologic Oncology Group (KGOG), Seoul, South Korea; National Cancer Center, Goyang, South Korea
National Cancer Center, Goyang and KGOG, South Korea
raw_author_name: G. Marquina
raw_affiliation_strings: Grupo Español de Investigación en Cáncer de Ovario (GEICO), Madrid, Spain; Department of Medical Oncology, Hospital Clínico San Carlos, School of Medicine, UCM, IdISSC, Madrid, Spain
Department of Medical Oncology, Hospital Clínico San Carlos, School of Medicine, UCM, IdISSC, Madrid and GEICO, Spain
raw_author_name: Ö. Altundağ
raw_affiliation_strings: Turkish Society of Gynecologic Oncology (TRSGO), Istanbul, Turkey; Department of Medical Oncology, Başkent University Hospital, Ankara, Turkey
Department of Medical Oncology, Başkent University Hospital, Ankara and TRSGO, Turkey
raw_author_name: A. Bergamini
raw_affiliation_strings: Multicenter Italian Trials in Ovarian Cancer and Gynecologic Malignancies (MITO), Rome, Italy; Department of Obstetrics and Gynecology, San Raffaele Hospital, Milan, Italy; Università Vita-Salute San Raffaele, Milan, Italy
Department of Obstetrics and Gynecology, San Raffaele Hospital, Milan, Università Vita-Salute San Raffaele, Milan, and MITO, Italy
raw_author_name: R. Sabatier
raw_affiliation_strings: Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens (GINECO), Paris, France; Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France
Departement of Medical Oncology, Institut Paoli-Calmettes, Marseille, and GINECO, France
raw_author_name: P. Wimberger
raw_affiliation_strings: Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Studiengruppe, Wiesbaden, Germany; Department of Obstetrics and Gynecology, Technische Universität Dresden and NCT Dresden, Dresden, Germany
Department of Obstetrics and Gynecology, Technische Universität Dresden and NCT Dresden, Dresden, and AGO Studiengruppe, Germany
raw_author_name: M.A. Gold
raw_affiliation_strings: Gynecologic Oncology Group Foundation (GOG-F), Philadelphia, USA; Oklahoma Cancer Specialists and Research Institute, Tulsa, USA
Oklahoma Cancer Specialists and Research Institute, Tulsa, OK, and GOG-F, USA
raw_author_name: J. Sehouli
raw_affiliation_strings: Charité - Department of Gynecology with Center of Oncological Surgery, Universitätsmedizin Berlin, Berlin, Germany; North Eastern German Society of Gynecological Oncology (NOGGO), Berlin, Germany
Charité - Department of Gynecology with Center of Oncological Surgery, Universitätsmedizin Berlin, Berlin, and North Eastern German Society of Gynecological Oncology (NOGGO), Germany
raw_author_name: T.-W. Park-Simon
raw_affiliation_strings: Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Studiengruppe, Wiesbaden, Germany; Medizinische Hochschule Hannover, Hannover, Germany
Medizinische Hochschule Hannover, Hannover, and AGO Studiengruppe, Germany
raw_author_name: E. Kent
raw_affiliation_strings: Oncology Biometrics, AstraZeneca, Cambridge
Oncology Biometrics, AstraZeneca, Cambridge, United Kingdom
raw_author_name: A. Correa
raw_affiliation_strings: Late-stage Development, Oncology R&D, AstraZeneca, Cambridge, UK
Late-stage Development, Oncology R&D, AstraZeneca, Cambridge, United Kingdom
raw_author_name: C. Aghajanian
raw_affiliation_strings: Gynecologic Oncology Group Foundation (GOG-F), Philadelphia, USA; Memorial Sloan Kettering Cancer Center, New York, USA
Memorial Sloan Kettering Cancer Center, New York, and GOG-F, USA