A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis
Year: 2025
Type: article
Language: en
Topic: Ferroptosis and cancer prognosis
Authors and affiliations:
raw_author_name: Svenja M. Lorenz
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Adam Wahida
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany; Molecular Signaling and Cell Death Unit, VIB-UGent Center for Inflammation Research, Flanders Institute for Biotechnology, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
raw_author_name: Mark J. Bostock
raw_affiliation_strings: Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany; Bavarian NMR Center and Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany
raw_author_name: Tobias Seibt
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany; Transplant Center, LMU University Hospital, LMU Munich, Munich, Germany
raw_author_name: André Santos Dias Mourão
raw_affiliation_strings: Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany
raw_author_name: Anastasia Levkina
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Dietrich Trümbach
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Mohamed Soudy
raw_affiliation_strings: Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg
raw_author_name: David Emler
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Nicola Rothammer
raw_affiliation_strings: Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
raw_author_name: Marcel S. Woo
raw_affiliation_strings: Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
raw_author_name: Jana K. Sonner
raw_affiliation_strings: Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
raw_author_name: Mariia Novikova
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Bernhard Henkelmann
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Maceler Aldrovandi
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Daniel F. Kaemena
raw_affiliation_strings: Institute of Virology, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
raw_author_name: Eikan Mishima
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany; Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
raw_author_name: Perrine Vermonden
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Zhi Zong
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Deng Chen
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Toshitaka Nakamura
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Junya Ito
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany; Laboratory of Food Function Analysis, Tohoku University Graduate School of Agricultural Science, Sendai, Japan
raw_author_name: Sebastian Doll
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Bettina Proneth
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Erika Bürkle
raw_affiliation_strings: Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Francesca Rizzollo
raw_affiliation_strings: Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB-KU Leuven Center for Cancer Biology Research, Leuven, Belgium
raw_author_name: Abril Escamilla Ayala
raw_affiliation_strings: VIB-KU Leuven Center for Brain & Disease Research, Light Microscopy Expertise Unit & VIB BioImaging Core, Leuven, Belgium; KU Leuven Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium
raw_author_name: Valeria Napolitano
raw_affiliation_strings: Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany
raw_author_name: Marta Kolonko-Adamska
raw_affiliation_strings: Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany
raw_author_name: Stefan Gaussmann
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raw_author_name: Juliane Merl-Pham
raw_affiliation_strings: Metabolomics and Proteomics Core Facility, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Stefanie Hauck
raw_affiliation_strings: Metabolomics and Proteomics Core Facility, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Anna Pertek
raw_affiliation_strings: iPSC Core Facility, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Tanja Orschmann
raw_affiliation_strings: iPSC Core Facility, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Emily van San
raw_affiliation_strings: Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
raw_author_name: Tom Vanden Berghe
raw_affiliation_strings: Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
raw_author_name: Daniela Hass
raw_affiliation_strings: Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Adriano Maida
raw_affiliation_strings: Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany
raw_author_name: Joris M. Frenz
raw_affiliation_strings: Clinical Cooperation Unit Pediatric Leukemia, DKFZ and Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany
raw_author_name: Lohans Pedrera
raw_affiliation_strings: Institute for Genetics, University of Cologne, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany
raw_author_name: Amalia Dolga
raw_affiliation_strings: Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands
raw_author_name: Markus Kraiger
raw_affiliation_strings: Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
raw_author_name: Martin Hrabé de Angelis
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raw_author_name: Helmut Fuchs
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raw_author_name: Gregor Ebert
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raw_author_name: Jerica Lenberg
raw_affiliation_strings: Department of Pediatrics, Division of Genetics, University of California, San Diego and Rady Children's Hospital, San Diego, San Diego, CA, USA; Rady Children's Institute for Genomic Medicine, San Diego, CA, USA
raw_author_name: Jennifer Friedman
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raw_author_name: Carolin Scale
raw_affiliation_strings: Department of Pediatric Radiology, Institute of Radiology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität, Berlin, Germany
raw_author_name: Patrizia Agostinis
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raw_author_name: Annemarie Zimprich
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raw_author_name: Daniela Vogt-Weisenhorn
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raw_author_name: Lillian Garrett
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raw_author_name: Sabine M. Hölter
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raw_author_name: Wolfgang Wurst
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raw_author_name: Enrico Glaab
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raw_author_name: Jan Lewerenz
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raw_author_name: Bastian Popper
raw_affiliation_strings: Biomedical Center, Core Facility Animal Models, Medical Faculty, LMU Munich, Martinsried, Germany
raw_author_name: Christian Sieben
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raw_author_name: Petra Steinacker
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raw_author_name: Hans Zischka
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raw_author_name: Sanath Kumar Ramesh
raw_affiliation_strings: CureGPX4.org, Seattle, WA, USA
raw_author_name: Scott Ayton
raw_affiliation_strings: Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, MEL, Australia
raw_author_name: Michelle Vincendeau
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raw_author_name: Manuel A. Friese
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raw_author_name: Kristen Wigby
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raw_author_name: Michael Sattler
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raw_author_name: Matthias Mann
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