Contemporary Medical Therapy for Heart Failure Across the Ejection Fraction Spectrum: The OPTIPHARM-HF Registry
Year: 2025
Type: article
Language: en
Topic: Cardiovascular Function and Risk Factors
Authors and affiliations:
raw_author_name: Riccardo M. Inciardi
raw_affiliation_strings: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,
Division of Cardiology, Department of Clinical Science and Education, Center for Heart Failure and Arrhythmia, Karolinska University Hospital , Stockholm ,
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Division of Cardiology, Department of Clinical Science and Education, Center for Heart Failure and Arrhythmia, Karolinska University Hospital, Stockholm, Sweden
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
raw_author_name: Maurizio Volterrani
raw_affiliation_strings: Department of Exercise Science and Medicine, San Raffaele Open University of Rome, Italy, and Cardiopulmonary Department, RCCS San Raffaele Roma , Rome ,
Department of Exercise Science and Medicine, San Raffaele Open University of Rome, Italy, and Cardiopulmonary Department, RCCS San Raffaele Roma, Rome, Italy
raw_author_name: Gianluigi Savarese
raw_affiliation_strings: Division of Cardiology, Department of Clinical Science and Education, Center for Heart Failure and Arrhythmia, Karolinska University Hospital , Stockholm ,
Division of Cardiology, Department of Clinical Science and Education, Center for Heart Failure and Arrhythmia, Karolinska University Hospital, Stockholm, Sweden
raw_author_name: Muthiah Vaduganathan
raw_affiliation_strings: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
raw_author_name: Chiara Oriecuia
raw_affiliation_strings: Department of Molecular and Translational Medicine, University of Brescia , Brescia ,
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
raw_author_name: Carlo M. Lombardi
raw_affiliation_strings: Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
raw_author_name: Cristina Gussago
raw_affiliation_strings: Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
raw_author_name: Piergiuseppe Agostoni
raw_affiliation_strings: Centro Cardiologico Monzino, IRCCS, Department of Clinical Sciences and Community Health , Milan ,
Department of Clinical and Community Medicine, University of Milan , Milano ,
Centro Cardiologico Monzino, IRCCS, Department of Clinical Sciences and Community Health, Milan, Italy
Department of Clinical and Community Medicine, University of Milan, Milano, Italy
raw_author_name: Pietro Ameri
raw_affiliation_strings: Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino , Genoa ,
Department of Internal Medicine, University of Genoa , Genoa ,
Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Department of Internal Medicine, University of Genoa, Genoa, Italy
raw_author_name: Giuseppe Armentaro
raw_affiliation_strings: Geriatrics Division. AOU R. Dulbecco, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro , Catanzaro ,
Geriatrics Division. AOU R. Dulbecco, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
raw_author_name: Chiara Arzilli
raw_affiliation_strings: Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna , Pisa ,
Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy
raw_author_name: Nadia Aspromonte
raw_affiliation_strings: Department of Cardiovascular ad Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart , Rome ,
Department of Cardiovascular ad Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy
raw_author_name: Andrea Attanasio
raw_affiliation_strings: Clinical Cardiology, IRCCS Policlinico San Donato, San Donato Milanese , Milan ,
Department of University of Wroclaw , Wroclaw ,
Department of University of Wroclaw, Wroclaw, Poland
Clinical Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
raw_author_name: Roberto Badagliacca
raw_affiliation_strings: Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Policlinico Umberto I , Rome ,
Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy
raw_author_name: Lucia Barbieri
raw_affiliation_strings: Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan , Milan ,
Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
raw_author_name: Pier Paolo Bocchino
raw_affiliation_strings: Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin , Turin ,
Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin, Turin, Italy
raw_author_name: Francesca Bursi
raw_affiliation_strings: Cardiology Department, University of Milano, San Paolo Hospital , Milan ,
Cardiology Department, University of Milano, San Paolo Hospital, Milan, Italy
raw_author_name: Matteo Cameli
raw_affiliation_strings: Division of Cardiology, Department of Medical Biotechnologies, University of Siena , Siena ,
Division of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, Italy
raw_author_name: Martino Canonero
raw_affiliation_strings: Department of Internal Medicine, University of Genoa , Genoa ,
Department of Internal Medicine, University of Genoa, Genoa, Italy
raw_author_name: Jeness S. Campodonico
raw_affiliation_strings: Centro Cardiologico Monzino, IRCCS, Department of Clinical Sciences and Community Health , Milan ,
Department of Molecular and Translational Medicine, University of Brescia , Brescia ,
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
Centro Cardiologico Monzino, IRCCS, Department of Clinical Sciences and Community Health, Milan, Italy
raw_author_name: Teresa Capovilla
raw_affiliation_strings: Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste , Trieste ,
Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy
raw_author_name: Erberto Carluccio
raw_affiliation_strings: Cardiology and Cardiovascular Pathophysiology, Santa Maria della Misericordia Hospital, University of Perugia , Perugia ,
Cardiology and Cardiovascular Pathophysiology, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy
raw_author_name: Stefano Carugo
raw_affiliation_strings: Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan , Milan ,
Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
raw_author_name: Vincenzo Castiglione
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Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy
raw_author_name: Dario Catapano
raw_affiliation_strings: Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital , Naples ,
Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, Naples, Italy
raw_author_name: Manlio Cipriani
raw_affiliation_strings: Mediterranean Institute for Transplantation and Advanced Specialized Therapies ISMETT-IRCCS , Palermo ,
Mediterranean Institute for Transplantation and Advanced Specialized Therapies ISMETT-IRCCS, Palermo, Italy
raw_author_name: Michele Correale
raw_affiliation_strings: Cardiology Unit, University Hospital Policlinico Riuniti, Department of Medical and Surgical Sciences, University of Foggia , Foggia ,
Cardiology Unit, University Hospital Policlinico Riuniti, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
raw_author_name: Domenico D'Amario
raw_affiliation_strings: Division of Cardiology, AOU Maggiore della Carità, Department of Translational Medicine, Università del Piemonte Orientale , Novara ,
Division of Cardiology, AOU Maggiore della Carità, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
raw_author_name: Raffaele De Caterina
raw_affiliation_strings: Cardiology Division, Cardiothoracic and Vascular Department, Pisa University Hospital, Department of Surgical, Medical and Molecular Pathology and of Critical Sciences, University of Pisa , Pisa ,
Cardiology Division, Cardiothoracic and Vascular Department, Pisa University Hospital, Department of Surgical, Medical and Molecular Pathology and of Critical Sciences, University of Pisa, Pisa, Italy
raw_author_name: Gaetano M. De Ferrari
raw_affiliation_strings: Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin , Turin ,
Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin, Turin, Italy
raw_author_name: Emilia D'Elia
raw_affiliation_strings: Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII , Bergamo ,
Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy
raw_author_name: Luca Di Odoardo
raw_affiliation_strings: Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII , Bergamo ,
Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy
raw_author_name: Michele Emdin
raw_affiliation_strings: Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna , Pisa ,
Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy
raw_author_name: Luigi Falco
raw_affiliation_strings: Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital , Naples ,
Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, Naples, Italy
raw_author_name: Giulia Ferrante
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Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
raw_author_name: Alessandra Fornaro
raw_affiliation_strings: Cardiology Unit, Careggi University Hospital , Florence ,
Cardiology Unit, Careggi University Hospital, Florence, Italy
raw_author_name: Paolo Fornaro
raw_affiliation_strings: Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
raw_author_name: Gionata Guastamiglio
raw_affiliation_strings: Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII , Bergamo ,
Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy
raw_author_name: Marco Guazzi
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Cardiology Department, University of Milano, San Paolo Hospital, Milan, Italy
raw_author_name: Massimo Iacoviello
raw_affiliation_strings: Cardiology Unit, University Hospital Policlinico Riuniti, Department of Medical and Surgical Sciences, University of Foggia , Foggia ,
Cardiology Unit, University Hospital Policlinico Riuniti, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
raw_author_name: Massimo Imazio
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Department of Medicine (DMED), University of Udine, and Cardiothoracic Department, University Hospital Santa Maria della Misericordia, ASUFC, Udine, Italy
raw_author_name: Enrico Incaminato
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Division of Cardiology, AOU Maggiore della Carità, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
raw_author_name: Maria Teresa La Rovere
raw_affiliation_strings: Department of Cardiology, Istituti Clinici Scientifici Maugeri IRCCS , Montescano (PV) ,
Department of Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Montescano (PV), Italy
raw_author_name: Sergio Leonardi
raw_affiliation_strings: Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Department of Molecular Medicine, University of Pavia , Pavia ,
Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Pavia, Italy
raw_author_name: Marta Maccallini
raw_affiliation_strings: Humanitas Clinical and Research Hospital IRCCS, Rozzano, Department of Biomedical Sciences, Humanitas University , Milan ,
Humanitas Clinical and Research Hospital IRCCS, Rozzano, Department of Biomedical Sciences, Humanitas University, Milan, Italy
raw_author_name: Giulia E. Mandoli
raw_affiliation_strings: Division of Cardiology, Department of Medical Biotechnologies, University of Siena , Siena ,
Division of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, Italy
raw_author_name: Daniele Masarone
raw_affiliation_strings: Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital , Naples ,
Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, Naples, Italy
raw_author_name: Marco Masetti
raw_affiliation_strings: Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna , Bologna ,
Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy
raw_author_name: Alberto Mazzoni
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Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
raw_author_name: Marta Mazzotta
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Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
raw_author_name: Marco Merlo
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Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy
raw_author_name: Luigi Moschini
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Division of Cardiology, Ospedale Oglio Po, ASST Cremona, Casalmaggiore, Italy
raw_author_name: Filippo Novarese
raw_affiliation_strings: Department of Internal Medicine, University of Genoa , Genoa ,
Department of Internal Medicine, University of Genoa, Genoa, Italy
raw_author_name: Alberto Palazzuoli
raw_affiliation_strings: Cardiovascular Diseases Unit, Cardiothoracic and Vascular Department, Le Scotte Hospital, University of Siena , Siena ,
Cardiovascular Diseases Unit, Cardiothoracic and Vascular Department, Le Scotte Hospital, University of Siena, Siena, Italy
raw_author_name: Maria C. Pastore
raw_affiliation_strings: Division of Cardiology, Department of Medical Biotechnologies, University of Siena , Siena ,
Division of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, Italy
raw_author_name: Giuseppe Patti
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Division of Cardiology, AOU Maggiore della Carità, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
raw_author_name: Roberto F.E. Pedretti
raw_affiliation_strings: Unit of Cardiology, Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni , Milan ,
Unit of Cardiology, Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy
raw_author_name: Stefano Pidello
raw_affiliation_strings: Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin , Turin ,
Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin, Turin, Italy
raw_author_name: Massimo F. Piepoli
raw_affiliation_strings: Clinical Cardiology, IRCCS Policlinico San Donato, San Donato Milanese , Milan ,
Department of University of Wroclaw , Wroclaw ,
Clinical Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
Department of University of Wroclaw, Wroclaw, Poland
raw_author_name: Giuseppe Pinto
raw_affiliation_strings: Humanitas Clinical and Research Hospital IRCCS, Rozzano, Department of Biomedical Sciences, Humanitas University , Milan ,
Humanitas Clinical and Research Hospital IRCCS, Rozzano, Department of Biomedical Sciences, Humanitas University, Milan, Italy
raw_author_name: Luciano Potena
raw_affiliation_strings: Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna , Bologna ,
Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy
raw_author_name: Claudia Raineri
raw_affiliation_strings: Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin , Turin ,
Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Department of Medical Sciences, University of Turin, Turin, Italy
raw_author_name: Filippo M. Rubbo
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Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy
raw_author_name: Mario Sabatino
raw_affiliation_strings: Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna , Bologna ,
Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy
raw_author_name: Andrea Salzano
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Department of Translational Medical Sciences, ‘Federico II’ University, Interdepartmental Center for Gender Medicine Research ‘GENESIS’, ‘Federico II’ University , Naples ,
Cardiology Unit, AORN A. Cardarelli, Naples, Italy
Department of Translational Medical Sciences, 'Federico II' University, Interdepartmental Center for Gender Medicine Research 'GENESIS', 'Federico II' University, Naples, Italy
raw_author_name: Angela Sciacqua
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Geriatrics Division. AOU R. Dulbecco, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
raw_author_name: Michele Senni
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Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy
raw_author_name: Paolo Severino
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Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy
raw_author_name: Gianfranco Sinagra
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Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy
raw_author_name: Barbara Sposato
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Division of Cardiology, Department of Clinical Science and Education, Center for Heart Failure and Arrhythmia, Karolinska University Hospital, Stockholm, Sweden
raw_author_name: Stefano Taddei
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Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
raw_author_name: Alessandro Valleggi
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Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy
raw_author_name: Carlo Vignati
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Department of Molecular and Translational Medicine, University of Brescia , Brescia ,
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
Centro Cardiologico Monzino, IRCCS, Department of Clinical Sciences and Community Health, Milan, Italy
raw_author_name: Dario Vizza
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Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy
raw_author_name: Claudia Specchia
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Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
raw_author_name: Giuseppe Rosano
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Department of Medical Sciences, Centre for Clinical and Basic Research, IRCCS San Raffaele Pisana, Rome, Italy
raw_author_name: Marco Metra
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Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
raw_author_name: the OPTIPHARM-HF investigators