Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk
Year: 2025
Type: article
Language: en
Topic: Mosquito-borne diseases and control
Authors and affiliations:
raw_author_name: Yimeng Wang
raw_affiliation_strings: Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
ReVacc, Inc., Cambridge, MA, USA
raw_author_name: Andrey Galkin
raw_affiliation_strings: Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Xiaoran Shang
raw_affiliation_strings: Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Alexander Marin
raw_affiliation_strings: Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Shaohua Jin
raw_affiliation_strings: Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Ting-Juan Ye
raw_affiliation_strings: Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Shridhar Bale
raw_affiliation_strings: Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA
raw_author_name: Chi-I Chiang
raw_affiliation_strings: Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Ananda Chowdhury
raw_affiliation_strings: Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Agnes L. Chenine
raw_affiliation_strings: Integrated BioTherapeutics, Inc., Rockville, MD, USA
raw_author_name: Ashley Turonis
raw_affiliation_strings: Integrated BioTherapeutics, Inc., Rockville, MD, USA
raw_author_name: Jack Greenhouse
raw_affiliation_strings: BIOQUAL, Inc., Rockville, MD, USA
raw_author_name: Rebecca Stone
raw_affiliation_strings: BIOQUAL, Inc., Rockville, MD, USA
raw_author_name: Jaclyn Wear
raw_affiliation_strings: BIOQUAL, Inc., Rockville, MD, USA
raw_author_name: Swagata Kar
raw_affiliation_strings: BIOQUAL, Inc., Rockville, MD, USA
raw_author_name: Hanne Andersen
raw_affiliation_strings: BIOQUAL, Inc., Rockville, MD, USA
raw_author_name: Yan-Jang S. Huang
raw_affiliation_strings: Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA
raw_author_name: Dana L. Vanlandingham
raw_affiliation_strings: Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA
raw_author_name: Stephen Higgs
raw_affiliation_strings: Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA
raw_author_name: Rena G. Lapidus
raw_affiliation_strings: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
raw_author_name: Thomas Fuerst
raw_affiliation_strings: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: David J. Weber
raw_affiliation_strings: Center for Biomolecular Therapeutic, Baltimore, MD, USA
Center for Biomolecular Therapeutics, Rockville, MD, USA
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Richard T. Wyatt
raw_affiliation_strings: Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA
raw_author_name: Christel Iffland
raw_affiliation_strings: OmniAb, Inc., Emeryville, CA, USA
raw_author_name: Theodore C. Pierson
raw_affiliation_strings: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
raw_author_name: Alexander K. Andrianov
raw_affiliation_strings: Institute for Bioscience and Biotechnology Research, Rockville, MD, USA
raw_author_name: Edwin Pozharski
raw_affiliation_strings: Center for Biomolecular Therapeutic, Baltimore, MD, USA. epozhars@umd.edu
Center for Biomolecular Therapeutics, Rockville, MD, USA. epozhars@umd.edu
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. epozhars@umd.edu
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. epozhars@umd.edu
raw_author_name: Yuxing Li
raw_affiliation_strings: Center for Biomolecular Therapeutic, Baltimore, MD, USA. yuxingli@umd.edu
Center for Biomolecular Therapeutics, Rockville, MD, USA. yuxingli@umd.edu
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. yuxingli@umd.edu
Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. yuxingli@umd.edu