Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors
Year: 2025
Type: article
Language: en
Topic: Protein Kinase Regulation and GTPase Signaling
Authors and affiliations:
raw_author_name: Hongfu Lu
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Sujing Shi
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Huaxing Yu
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Deheng Sun
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Haoyu Zhang
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Hui Cui
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Xin Cai
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Xiao Ding
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Shan Chen
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Man Zhang
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Jinxin Liu
raw_affiliation_strings: Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
raw_author_name: Ryan Shi
raw_affiliation_strings: The Bishop’s School, 7607 La Jolla Blvd, La Jolla, California 92037, United States
The Bishop's School, 7607 La Jolla Blvd, La Jolla, California 92037, United States
raw_author_name: Alex Aliper
raw_affiliation_strings: Insilico Medicine AI Ltd
Insilico Medicine AI Ltd, Masdar City, Abu Dhabi 145748, UAE
raw_author_name: Feng Ren
raw_affiliation_strings: Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park
Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park, Hong Kong 999077, China
raw_author_name: Alex Zhavoronkov
raw_affiliation_strings: Insilico Medicine AI Ltd
Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park
Insilico Medicine Shanghai Ltd, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China
Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park, Hong Kong 999077, China
Insilico Medicine AI Ltd, Masdar City, Abu Dhabi 145748, UAE