Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer
Year: 2025
Type: article
Language: en
Topic: Single-cell and spatial transcriptomics
Authors and affiliations:
raw_author_name: Yingzheng Tan
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Wenliang Tan
raw_affiliation_strings: Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Yanchao Liang
raw_affiliation_strings: Department of Respiratory and Critical Care Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Yunzhu Long
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Shuanghua Chen
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
Hunan Traditional Chinese Medical College, Zhuzhou, Hunan, China
raw_author_name: Qihao Hu
raw_affiliation_strings: Department of Cardiothoracic Surgery, Changde Hospital Affiliated to Xiangya School of Medicine, Central South University, Changde, Hunan, China
raw_author_name: Yangjing Ou
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Jingli Fu
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Huan Chen
raw_affiliation_strings: Department of Rehabilitation Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Fangyuan Ren
raw_affiliation_strings: Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Jun Ye
raw_affiliation_strings: Trauma Center, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Qing Zhou
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Sheng Li
raw_affiliation_strings: Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Xiaojin He
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Qianqian Wang
raw_affiliation_strings: Department of Oncology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Yueming Shen
raw_affiliation_strings: Department of Radiology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China
raw_author_name: Haiyuan Lu
raw_affiliation_strings: Clinical Laboratory Department, Xiangya hospital, Central South University, Changsha, Hunan, China
Hunan Vigorzoe Biotechnology Co., Ltd, Changsha, Hunan, China
raw_author_name: Daichao Wu
raw_affiliation_strings: The First Affiliated Hospital, Laboratory of Structural Immunology, Hengyang Medical School, University of South China, Hengyang, Hunan, China. wudaichao@usc.edu.cn
Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. wudaichao@usc.edu.cn
raw_author_name: Anbo Gao
raw_affiliation_strings: Clinical Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China. gaoanbo@usc.edu.cn
Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. gaoanbo@usc.edu.cn
raw_author_name: Xun Chen
raw_affiliation_strings: Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. chenxun@csu.edu.cn
Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. chenxun@csu.edu.cn
raw_author_name: Yukun Li
raw_affiliation_strings: Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. yukun_li@csu.edu.cn
Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. yukun_li@csu.edu.cn