CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer’s disease
Year: 2025
Type: article
Language: en
Topic: Single-cell and spatial transcriptomics
Authors and affiliations:
raw_author_name: Nicole F. O. Green
raw_affiliation_strings: Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Gavin J. Sutton
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Javier Pérez-Burillo
raw_affiliation_strings: RNA Institute, University of New South Wales, Sydney, New South Wales, Australia
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Juli Wang
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Samuel Bagot
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Hannah G. Danon
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Kieran Walsh
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Akira Gokool
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Samantha A. Miles
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Guang Yang
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Charles A. Herring
raw_affiliation_strings: ARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia
Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia
raw_author_name: Yuheng Liang
raw_affiliation_strings: BioMedical Machine Learning Lab, The Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Grant Pfundstein
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Vladimir Sytnyk
raw_affiliation_strings: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Hamid Alinejad-Rokny
raw_affiliation_strings: BioMedical Machine Learning Lab, The Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia
Health Data Analytics Program, Centre for Applied Artificial Intelligence, Macquarie University, Sydney, New South Wales, Australia
UNSW Data Science Hub, University of New South Wales, Sydney, New South Wales, Australia
raw_author_name: Ryan Lister
raw_affiliation_strings: ARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia
Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia
raw_author_name: Joseph Rosenbluh
raw_affiliation_strings: Cancer Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia
raw_author_name: Johann A. Gagnon-Bartsch
raw_affiliation_strings: Department of Statistics, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Irina Voineagu
raw_affiliation_strings: Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia. i.voineagu@unsw.edu.au
RNA Institute, University of New South Wales, Sydney, New South Wales, Australia. i.voineagu@unsw.edu.au
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia. i.voineagu@unsw.edu.au