Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi
Year: 2025
Type: article
Language: en
Topic: Fungal Infections and Studies
Authors and affiliations:
raw_author_name: Xuefei Chen
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: H. Diessel Duan
raw_affiliation_strings: Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA
raw_author_name: Michael J. Hoy
raw_affiliation_strings: Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA
raw_author_name: Kalinka Koteva
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Michaela Spitzer
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Allison K. Guitor
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Emily Puumala
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada
raw_author_name: Aline A. Fiebig
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Guanggan Hu
raw_affiliation_strings: Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
raw_author_name: Bonnie Yiu
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada
raw_author_name: Sommer Chou
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Zhuyun Bian
raw_affiliation_strings: Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA
raw_author_name: Yeseul Choi
raw_affiliation_strings: Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA
raw_author_name: Amelia Bing Ya Guo
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Wenliang Wang
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Sheng Sun
raw_affiliation_strings: Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA
raw_author_name: Nicole Robbins
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada
raw_author_name: Anna Floyd Averette
raw_affiliation_strings: Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA
raw_author_name: Michael A. Cook
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Ray Truant
raw_affiliation_strings: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada
raw_author_name: Lesley T. MacNeil
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada
raw_author_name: Eric D. Brown
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: James W. Kronstad
raw_affiliation_strings: Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
raw_author_name: Brian K. Coombes
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada
raw_author_name: Leah E. Cowen
raw_affiliation_strings: Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada
raw_author_name: Joseph Heitman
raw_affiliation_strings: Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA
raw_author_name: Huilin Li
raw_affiliation_strings: Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: huilin.li@vai.org
raw_author_name: Gerard D. Wright
raw_affiliation_strings: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: wrightge@mcmaster.ca