Changes in Intraoperative Rocuronium Dosing after the Introduction of Sugammadex and Association with Postoperative Respiratory Complications: A Retrospective Cohort Study
Year: 2025
Type: article
Language: en
Topic: Anesthesia and Sedative Agents
Authors and affiliations:
raw_author_name: Luca J. Wachtendorf
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp
Conflicts of interest: Luca J. Wachtendorf received funding for investigator-initiated studies from Merck &amp
Equal contributions
raw_author_name: Lars Kaiser
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Equal contributions
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
raw_author_name: Elena Ahrens
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp
Conflicts of interest: Luca J. Wachtendorf received funding for investigator-initiated studies from Merck &amp
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Center for Anesthesia Research Excellence (CARE), Beth Israel Deaconess Medical Center, Boston, MA, USA
raw_author_name: Theresa Tenge
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Anesthesiology, Medical Faculty, University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany
Center for Anesthesia Research Excellence (CARE), Beth Israel Deaconess Medical Center, Boston, MA, USA
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp
Conflicts of interest: Luca J. Wachtendorf received funding for investigator-initiated studies from Merck &amp
Department of Anesthesiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine-University, Germany
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
raw_author_name: Sophia Riesemann
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Center for Anesthesia Research Excellence (CARE), Beth Israel Deaconess Medical Center, Boston, MA, USA
raw_author_name: Xiaohan Xu
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Anesthesiology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing, China
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
Center for Anesthesia Research Excellence (CARE), Beth Israel Deaconess Medical Center, Boston, MA, USA
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Co., being a member of the Associate Editorial Board of the British Journal of Anaesthesia and holding patents for acyclic cucurbiturils for reversal of drugs of abuse and neuromuscular blocking agents (patent numbers 9956229 and 9469648) outside the submitted work. Maximilian S. Schaefer received funding for investigator-initiated studies from Merck &amp
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp
Department of Anesthesiology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Beijing, China
raw_author_name: Denys Shay
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
Center for Anesthesia Research Excellence (CARE), Beth Israel Deaconess Medical Center, Boston, MA, USA
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Co., being a member of the Associate Editorial Board of the British Journal of Anaesthesia and holding patents for acyclic cucurbiturils for reversal of drugs of abuse and neuromuscular blocking agents (patent numbers 9956229 and 9469648) outside the submitted work. Maximilian S. Schaefer received funding for investigator-initiated studies from Merck &amp
raw_author_name: Dario von Wedel
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Institute of Medical Informatics, Charite University Hospital Berlin, Berlin, Germany
Institute of Medical Informatics, Charité – Universitätsmedizin Berlin, Invalidenstraße 90, Berlin, 10115, Germany
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
raw_author_name: Béla-Simon Paschold
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Center for Anesthesia Research Excellence (CARE), Beth Israel Deaconess Medical Center, Boston, MA, USA
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
raw_author_name: Guanqing Chen
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
raw_author_name: Hannah Kiziltug
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
raw_author_name: Satya Krishna Ramachandran
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
Conflicts of interest: Luca J. Wachtendorf received funding for investigator-initiated studies from Merck &amp
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp
raw_author_name: Philipp J. Fassbender
raw_affiliation_strings: Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York
Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
raw_author_name: Peter Kienbaum
raw_affiliation_strings: Department of Anesthesiology, Medical Faculty, University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany
Department of Anesthesiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine-University, Germany
raw_author_name: Matthias Eikermann
raw_affiliation_strings: Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York
Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Conflicts of interest: Luca J. Wachtendorf received funding for investigator-initiated studies from Merck &amp
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
raw_author_name: Maximilian S. Schaefer
raw_affiliation_strings: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Anesthesia Research Excellence, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Anesthesiology, Medical Faculty, University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany
Paykel Healthcare and Mindray Medical International Limited. He received an unrestricted philanthropic grant from Dr. Jeffrey and Judith Buzen. No other disclosures were reported. All other authors have no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous three years, and no other relationships or activities that could appear to have influenced the submitted work
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Department of Anesthesiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine-University, Germany
Co., being a member of the Associate Editorial Board of the British Journal of Anaesthesia and holding patents for acyclic cucurbiturils for reversal of drugs of abuse and neuromuscular blocking agents (patent numbers 9956229 and 9469648) outside the submitted work. Maximilian S. Schaefer received funding for investigator-initiated studies from Merck &amp
Center for Anesthesia Research Excellence (CARE), Beth Israel Deaconess Medical Center, Boston, MA, USA
Co. and received a grant from the American Society of Anesthesiologists (ASA) Committee on Professional Diversity, which do not pertain to this manuscript. He is an Associate Editor at BMC Anesthesiology. Elena Ahrens received a grant from the ASA Committee on Professional Diversity, unrelated to this manuscript, and is an Associate Editor at BMC Anesthesiology. Theresa Tenge reports funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - TE 1567/1-1 (Walter Benjamin Fellowship) unrelated to this study. Xiaohan Xu received funding from National Natural Science Foundation of China, which does not pertain to this manuscript. Denys Shay is an Associate Editor at BMC Anesthesiology. Satya Krishna Ramachandran received honoraria from Fresenius Kabi USA and research grants from Fresenius Kabi USA as well as from the Controlled Risk Insurance Company. He is an Associate Editor at the Journal of Clinical Anesthesia. Matthias Eikermann reports funding from the National Institutes of Health and Merck &amp