An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain–related behaviors in humanized mice
Year: 2025
Type: article
Language: en
Topic: Pain Mechanisms and Treatments
Authors and affiliations:
raw_author_name: Ankit Uniyal
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Niyada Hin
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: Chi Zhang
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Qian Xu
raw_affiliation_strings: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Qian Huang
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Ilyas Berhane
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: Ajit G. Thomas
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: John Maragakis
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: Sadakatali Gori
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: Jing Liu
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Qin Zheng
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Xiang Cui
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Qi Peng
raw_affiliation_strings: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Jieru Wan
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Rana Rais
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: Barbara S. Slusher
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: Srinivasa. N. Raja
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Xinzhong Dong
raw_affiliation_strings: Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
raw_author_name: Takashi Tsukamoto
raw_affiliation_strings: Johns Hopkins Drug Discovery and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
raw_author_name: Yun Guan
raw_affiliation_strings: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Department of Neurological Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA