Self-activated prodrug nanocomposites reprogramming lactic acid metabolism to initiate acidosis-endoplasmic reticulum stress cascade and potentiate immunogenic cell death for enhanced liver cancer therapy
Year: 2025
Type: article
Language: en
Topic: Cancer, Hypoxia, and Metabolism
Authors and affiliations:
raw_author_name: JingQuan Chen
raw_affiliation_strings: School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China
raw_author_name: WeiYi Cheng
raw_affiliation_strings: School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China
raw_author_name: WeiYe Ren
raw_affiliation_strings: School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China
raw_author_name: LiTing He
raw_affiliation_strings: School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China
raw_author_name: Xiaoqi Wang
raw_affiliation_strings: Department of Oncology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310013, China
Department of Radiation Oncology, Zhejiang Hospital, Hangzhou, 310030, China
Zhejiang Key Laboratory of Geriatrics, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310030, China
raw_author_name: Xiujuan Hong
raw_affiliation_strings: Zhejiang Key Laboratory of Geriatrics, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310030, China
raw_author_name: ChenLi Wang
raw_affiliation_strings: The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China
raw_author_name: Yajun Wu
raw_affiliation_strings: Department of Oncology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310013, China
Department of Radiation Oncology, Zhejiang Hospital, Hangzhou, 310030, China
raw_author_name: Dandan Bao
raw_affiliation_strings: Department of Dermatology & Cosmetology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China. baodandan1990@163.com
Department of Dermatology & Cosmetology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China
raw_author_name: Zhibing Wu
raw_affiliation_strings: Department of Oncology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310013, China. wuzhibing@zju.edu.cn
Department of Radiation Oncology, Zhejiang Hospital, Hangzhou, 310030, China. wuzhibing@zju.edu.cn
Hangzhou Institute of Medicine Chinese Academy of Sciences, Hangzhou, China. wuzhibing@zju.edu.cn
Zhejiang Key Laboratory of Geriatrics, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310030, China. wuzhibing@zju.edu.cn
Department of Oncology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310013, China
raw_author_name: Yinghui Wei
raw_affiliation_strings: School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China. yhw_nn@zcmu.edu.cn
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. yhw_nn@zcmu.edu.cn
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China
raw_author_name: Ji-Gang Piao
raw_affiliation_strings: School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China. jgpiao@zcmu.edu.cn
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. jgpiao@zcmu.edu.cn
School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China