MCL1 modulates mTORC1 signaling to promote bioenergetics and tumorigenesis
Year: 2025
Type: article
Language: en
Topic: PI3K/AKT/mTOR signaling in cancer
Authors and affiliations:
raw_author_name: Wentao Gui
raw_affiliation_strings: Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic
Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Mildred-Scheel Early Career Center, National Center for Tumor Diseases Dresden (NCT/UCC) University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
raw_author_name: Petr Paral
raw_affiliation_strings: Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague, Czech Republic
Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
raw_author_name: Bhavuk Dhamija
raw_affiliation_strings: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Eman Hagag
raw_affiliation_strings: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Martin Dusa
raw_affiliation_strings: Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague, Czech Republic
raw_author_name: Jana Humajova
raw_affiliation_strings: Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague, Czech Republic
raw_author_name: Pavla V. Francova
raw_affiliation_strings: Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague, Czech Republic
raw_author_name: Jan Kucka
raw_affiliation_strings: Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic
raw_author_name: Jan Pankrac
raw_affiliation_strings: Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague, Czech Republic
raw_author_name: Caroline Schütz
raw_affiliation_strings: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Vasileios Armenis
raw_affiliation_strings: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Filippo Ferrucci
raw_affiliation_strings: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Mildred-Scheel Early Career Center, National Center for Tumor Diseases Dresden (NCT/UCC) University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
raw_author_name: Mario Schubert
raw_affiliation_strings: Institute of Pharmacology and Toxicology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Kaomei Guan
raw_affiliation_strings: Institute of Pharmacology and Toxicology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
raw_author_name: Franziska Baenke
raw_affiliation_strings: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Daniel E. Stange
raw_affiliation_strings: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
raw_author_name: Lorenz H. Lehmann
raw_affiliation_strings: Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany
German Center for Cardiovascular Research (DZHK), Heidelberg, Mannheim, Germany
raw_author_name: Wolfram Weckwerth
raw_affiliation_strings: Department of Functional and Evolutionary Ecology, Molecular Systems Biology (MOSYS), University of Vienna, Vienna, Austria
Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria
raw_author_name: Peter Mirtschink
raw_affiliation_strings: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
raw_author_name: Sofia Traikov
raw_affiliation_strings: Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
raw_author_name: Belmonte Giuseppe
raw_affiliation_strings: Section of Pathological Anatomy, Department of Medicine, Surgery and Neuroscience, University Hospital of Siena, Siena, Italy
raw_author_name: Clelia Miracco
raw_affiliation_strings: Section of Pathological Anatomy, Department of Medicine, Surgery and Neuroscience, University Hospital of Siena, Siena, Italy
raw_author_name: Martin Bornhäuser
raw_affiliation_strings: Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Saverio Minucci
raw_affiliation_strings: Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; Department of Hemato-Oncology, Università Statale di Milano, Milan, Italy
Department of Hemato-Oncology, Università Statale di Milano, Milan, Italy
Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy
raw_author_name: Ludek Sefc
raw_affiliation_strings: Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague, Czech Republic
raw_author_name: Libor Macurek
raw_affiliation_strings: Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
raw_author_name: Mohamed Elgendy
raw_affiliation_strings: Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. mohamed.elgendy@ukdd.de
Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. mohamed.elgendy@ukdd.de
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. mohamed.elgendy@ukdd.de
Mildred-Scheel Early Career Center, National Center for Tumor Diseases Dresden (NCT/UCC) University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. mohamed.elgendy@ukdd.de
National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany. mohamed.elgendy@ukdd.de
Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany
Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany