Hepatic adaptation to chronic metabolic stress primes tumorigenesis
Year: 2025
Type: article
Language: en
Topic: Single-cell and spatial transcriptomics
Authors and affiliations:
raw_author_name: Constantine N. Tzouanas
raw_affiliation_strings: Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Harvard-MIT Program in Health Sciences and Technology, Harvard Medical School, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Jessica E.S. Shay
raw_affiliation_strings: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Division of Gastroenterology, Hepatology & Nutrition, University of Utah, Salt Lake City, UT, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Marc S. Sherman
raw_affiliation_strings: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
raw_author_name: Adam J. Rubin
raw_affiliation_strings: Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Benjamin E. Mead
raw_affiliation_strings: Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Tyler T. Dao
raw_affiliation_strings: Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Junyan Tao
raw_affiliation_strings: Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
raw_author_name: Brandon M. Lehrich
raw_affiliation_strings: Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA
raw_author_name: George Eng
raw_affiliation_strings: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Jeffrey Patterson-Fortin
raw_affiliation_strings: Division of Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
raw_author_name: Titus Butzlaff
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raw_author_name: Miyeko D. Mana
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raw_author_name: Kellie E. Kolb
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raw_author_name: Chad Walesky
raw_affiliation_strings: Division of Gastroenterology, Hepatology & Nutrition, University of Utah, Salt Lake City, UT, USA
raw_author_name: Brian J. Pepe-Mooney
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raw_author_name: Colton J. Smith
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raw_author_name: Sanjay M. Prakadan
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raw_author_name: Michelle L. Ramseier
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raw_author_name: Yuzhou Evelyn Tong
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raw_author_name: Julia Joung
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raw_author_name: Fangtao Chi
raw_affiliation_strings: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
raw_author_name: Thomas McMahon-Skates
raw_affiliation_strings: Division of Gastroenterology, Hepatology & Nutrition, University of Utah, Salt Lake City, UT, USA
raw_author_name: Carolyn L. Winston
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raw_author_name: Woo-Jeong Jeong
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raw_author_name: Katherine J. Aney
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raw_author_name: Ethan Chen
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raw_author_name: Sahar Nissim
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raw_author_name: Feng Zhang
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raw_author_name: Vikram Deshpande
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raw_author_name: Satdarshan P. Monga
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raw_author_name: Georg M. Lauer
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raw_author_name: Wolfram Goessling
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