Digital twins for in vivo metabolic flux estimations in patients with brain cancer
Year: 2025
Type: article
Language: en
Topic: Single-cell and spatial transcriptomics
Authors and affiliations:
raw_author_name: Baharan Meghdadi
raw_affiliation_strings: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Wajd N. Al-Holou
raw_affiliation_strings: Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Andrew J. Scott
raw_affiliation_strings: Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Anjali Mittal
raw_affiliation_strings: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Ningning Liang
raw_affiliation_strings: Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Palavalasa Sravya
raw_affiliation_strings: Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Abhinav Achreja
raw_affiliation_strings: Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Alexandra O’Brien
raw_affiliation_strings: Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Kathy Do
raw_affiliation_strings: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Zhe Wu
raw_affiliation_strings: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Jiane Feng
raw_affiliation_strings: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Nathan R. Qi
raw_affiliation_strings: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Vijay Tarnal
raw_affiliation_strings: Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Sriram Venneti
raw_affiliation_strings: Department of Pathology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: C. Ryan Miller
raw_affiliation_strings: Department of Pathology, University of Alabama Birmingham, Birmingham, AL, USA
raw_author_name: Jann N. Sarkaria
raw_affiliation_strings: Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA
raw_author_name: Weihua Zhou
raw_affiliation_strings: Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Theodore S. Lawrence
raw_affiliation_strings: Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
raw_author_name: Costas A. Lyssiotis
raw_affiliation_strings: Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. Electronic address: clyssiot@umich.edu
raw_author_name: Daniel R. Wahl
raw_affiliation_strings: Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. Electronic address: dwahl@med.umich.edu
raw_author_name: Deepak Nagrath
raw_affiliation_strings: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: dnagrath@umich.edu