Organoids and organs-on-chips for accelerating R&amp;D and clinical translation in Orthopaedics: Emerging opportunities and regulatory pathways
Year: 2025
Type: article
Language: en
Topic: 3D Printing in Biomedical Research
Authors and affiliations:
raw_author_name: Yiting Lei
raw_affiliation_strings: Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
raw_author_name: Yuwei Zhang
raw_affiliation_strings: Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
raw_author_name: Liangbin Zhou
raw_affiliation_strings: Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
raw_author_name: Zhilong Zhou
raw_affiliation_strings: Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
raw_author_name: Mario Rothbauer
raw_affiliation_strings: Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria
raw_author_name: Long Bai
raw_affiliation_strings: Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China
raw_author_name: Jiankun Xu
raw_affiliation_strings: Department of Orthopedics&Traumatology, Disruptive Innovation Centre for Spatiotemporal Imaging in Li Ka Shing Health and Science Institute, and Joint Laboratory for Biomaterials SIAT-HKU- CUHK, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
Shenzhen University of Advanced Technology, and Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Shenzhen, 518000, China
raw_author_name: Denghui Xie
raw_affiliation_strings: Department of Orthopedic Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China
raw_author_name: Ali Mobasheri
raw_affiliation_strings: Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Faculté de Médecine, Université de Liège, Liège, Belgium
Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, FI-90014, Finland
raw_author_name: Xin Zhang
raw_affiliation_strings: Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China
raw_author_name: Dongquan Shi
raw_affiliation_strings: Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu, 210008, China
raw_author_name: Changhai Ding
raw_affiliation_strings: Clinical Research Centre, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, 102218, China
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China
raw_author_name: Jiake Xu
raw_affiliation_strings: Department of Orthopedics&Traumatology, Disruptive Innovation Centre for Spatiotemporal Imaging in Li Ka Shing Health and Science Institute, and Joint Laboratory for Biomaterials SIAT-HKU- CUHK, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
Shenzhen University of Advanced Technology, and Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Shenzhen, 518000, China
raw_author_name: Wei Huang
raw_affiliation_strings: Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
raw_author_name: Shiqing Feng
raw_affiliation_strings: Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China
raw_author_name: Liu Yang
raw_affiliation_strings: Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
raw_author_name: Yuxiao Lai
raw_affiliation_strings: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Shenzhen, 518000, China
raw_author_name: Guanghua Lei
raw_affiliation_strings: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, China
raw_author_name: Zhuojing Luo
raw_affiliation_strings: Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
raw_author_name: Chenzhong Li
raw_affiliation_strings: Department of Biomedical Engineering, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen, 518172, China
raw_author_name: Jiacan Su
raw_affiliation_strings: Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China
raw_author_name: David J. Hunter
raw_affiliation_strings: Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, 2065, Australia
raw_author_name: Di Chen
raw_affiliation_strings: Shenzhen University of Advanced Technology, and Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Shenzhen, 518000, China
raw_author_name: Zhongze Gu
raw_affiliation_strings: State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
raw_author_name: Ling Qin
raw_affiliation_strings: Department of Orthopedics&Traumatology, Disruptive Innovation Centre for Spatiotemporal Imaging in Li Ka Shing Health and Science Institute, and Joint Laboratory for Biomaterials SIAT-HKU- CUHK, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
raw_author_name: Rocky S. Tuan
raw_affiliation_strings: Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
InnoHK Center for Neuromusculoskeletal Restorative Medicine, Hong Kong Science Park, SAR, 999077, China
Institute for Tissue Engineering and Regenerative Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
raw_author_name: Zhong Alan Li
raw_affiliation_strings: Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
InnoHK Center for Neuromusculoskeletal Restorative Medicine, Hong Kong Science Park, SAR, 999077, China
Institute for Tissue Engineering and Regenerative Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China
Peter Hung Pain Research Institute, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, Shatin, 999077, China