Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
Year: 2025
Type: article
Language: en
Topic: Immunotherapy and Immune Responses
Authors and affiliations:
raw_author_name: Diana Castaño
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Emily Bettini
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Binod Kumar
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Aleksey Chudnovskiy
raw_affiliation_strings: Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA
raw_author_name: Anna Siv
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Giulia Protti
raw_affiliation_strings: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
raw_author_name: Sandra Nakadakari-Higa
raw_affiliation_strings: Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA
raw_author_name: Simona Ceglia
raw_affiliation_strings: Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA
raw_author_name: Nina De Luna
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Joy E. Chiu
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Katlyn Lederer
raw_affiliation_strings: Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA
raw_author_name: Shuk Hang Li
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Hassaan Ibrahim
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Hiromi Muramatsu
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Thandiswa Mdluli
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Edit Abraham
raw_affiliation_strings: Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary
raw_author_name: Sinem E. Sahingur
raw_affiliation_strings: Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Ivan Maillard
raw_affiliation_strings: Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA
raw_author_name: Ying K. Tam
raw_affiliation_strings: Acuitas Therapeutics, Vancouver, BC, Canada
raw_author_name: Sunny Shin
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Scott E. Hensley
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Jonathan J. Miner
raw_affiliation_strings: Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Rheumatology, Department of Medicine, RVCL Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Zoltan Lipinszki
raw_affiliation_strings: Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary; ATGandCo Biotechnology Ltd, Mórahalom, Hungary
raw_author_name: Andrea Reboldi
raw_affiliation_strings: Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA
raw_author_name: Norbert Pardi
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
raw_author_name: Roberto Spreafico
raw_affiliation_strings: Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA
raw_author_name: Gabriel D. Victora
raw_affiliation_strings: Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA
raw_author_name: Michela Locci
raw_affiliation_strings: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: michela.locci@pennmedicine.upenn.edu