A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetes
Year: 2025
Type: article
Language: en
Topic: Pancreatic function and diabetes
Authors and affiliations:
raw_author_name: Dingyu Liu
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Bicna Song
raw_affiliation_strings: Center for Cancer and Immunology Research, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20010, USA
Center for Genetic Medicine Research, Children's National Hospital. 111 Michigan Ave NW, Washington, DC 20010, USA
raw_author_name: Zhaoheng Li
raw_affiliation_strings: Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA
raw_author_name: Stephen Zhang
raw_affiliation_strings: Department of Genetics and Computer Science, BASE Research Initiative, Betty Irene Moore Children's Heart Center, Stanford University, Stanford, CA, USA
School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia
raw_author_name: Tabassum Fabiha
raw_affiliation_strings: Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
raw_author_name: Jiahui Zhao
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY 10065, USA
raw_author_name: Ayaka Inoki
raw_affiliation_strings: Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY 10065, USA
raw_author_name: Julie Piccand
raw_affiliation_strings: CNRS, UMR 7104, F-67400 Illkirch, France
IGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire, F-67400 Illkirch, France
INSERM, UMR-S 1258, F-67400 Illkirch, France
Université de Strasbourg, IGBMC UMR 7104- UMR-S 1258, F-67400 Illkirch, France
raw_author_name: Chew-Li Soh
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Gary Dixon
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY 10065, USA
raw_author_name: Aaron Zhong
raw_affiliation_strings: The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Nan Hu
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Renhe Luo
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Batu Ozlusen
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Vipin Menon
raw_affiliation_strings: Center for Genetic Medicine Research, Children's National Hospital. 111 Michigan Ave NW, Washington, DC 20010, USA
Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore MD 21201, USA
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD 21201, USA
University of Maryland-Institute for Health Computing, North Bethesda MD 20852, USA
raw_author_name: Ting Zhou
raw_affiliation_strings: The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Xiaojie Qiu
raw_affiliation_strings: Department of Genetics and Computer Science, BASE Research Initiative, Betty Irene Moore Children's Heart Center, Stanford University, Stanford, CA, USA
raw_author_name: Gerard Gradwohl
raw_affiliation_strings: CNRS, UMR 7104, F-67400 Illkirch, France
IGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire, F-67400 Illkirch, France
INSERM, UMR-S 1258, F-67400 Illkirch, France
Université de Strasbourg, IGBMC UMR 7104- UMR-S 1258, F-67400 Illkirch, France
raw_author_name: Dapeng Yang
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA
raw_author_name: Kushal Dey
raw_affiliation_strings: Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
raw_author_name: Wei Sun
raw_affiliation_strings: Biostatistics Program, Public Health Science Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA
Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA
raw_author_name: Wei Li
raw_affiliation_strings: Center for Genetic Medicine Research, Children's National Hospital. 111 Michigan Ave NW, Washington, DC 20010, USA
Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore MD 21201, USA
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD 21201, USA
University of Maryland-Institute for Health Computing, North Bethesda MD 20852, USA
raw_author_name: Danwei Huangfu
raw_affiliation_strings: Developmental Biology Program, Sloan Kettering Institute; 1275 York Avenue, New York, NY 10065, USA