Cholangiocarcinoma 2026: status quo, unmet needs and priorities
Year: 2025
Type: review
Language: en
Topic: Cholangiocarcinoma and Gallbladder Cancer Studies
Authors and affiliations:
raw_author_name: Jesus M. Banales
raw_affiliation_strings: Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain. jesusmaria.banalesasurmendi@bio-gipuzkoa.eus
Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain. jesusmaria.banalesasurmendi@bio-gipuzkoa.eus
Ikerbasque, Basque Foundation for Science, Bilbao, Spain. jesusmaria.banalesasurmendi@bio-gipuzkoa.eus
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain. jesusmaria.banalesasurmendi@bio-gipuzkoa.eus
Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute – Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain
Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Pedro M. Rodrigues
raw_affiliation_strings: Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain. pedromiguel.rodriguesvieira@bio-gipuzkoa.eus
Ikerbasque, Basque Foundation for Science, Bilbao, Spain. pedromiguel.rodriguesvieira@bio-gipuzkoa.eus
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain. pedromiguel.rodriguesvieira@bio-gipuzkoa.eus
Ikerbasque, Basque Foundation for Science, Bilbao, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute – Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain
raw_author_name: Silvia Affò
raw_affiliation_strings: Cancer Program, Tumor Microenvironment Plasticity and Heterogeneity Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
raw_author_name: Jesper B. Andersen
raw_affiliation_strings: Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Patricia Aspichueta
raw_affiliation_strings: BioBizkaia Health Research Institute, Barakaldo, Spain
Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Luke Boulter
raw_affiliation_strings: Cancer Research UK Scotland Centre, Edinburgh, UK
MRC Human Genetics Unit, Institute of Genetics and Cancer, Edinburgh, UK
raw_author_name: John Bridgewater
raw_affiliation_strings: UCL Cancer Institute, Department of Medical Oncology, London, UK
raw_author_name: Diego F. Calvisi
raw_affiliation_strings: Institute of Pathology, University of Regensburg, Regensburg, Germany
raw_author_name: Andres Cardenas
raw_affiliation_strings: GI and Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Barcelona, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Vincenzo Cardinale
raw_affiliation_strings: Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
raw_author_name: Guido Carpino
raw_affiliation_strings: Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy
raw_author_name: Cédric Coulouarn
raw_affiliation_strings: Inserm, Univ Rennes, OSS (Oncogenesis, Stress, Signaling) UMR_S 1242, Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France
raw_author_name: Cristina Dopazo
raw_affiliation_strings: Department of HPB Surgery and Transplants, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Universitat Autónoma de Barcelona, Barcelona, Spain
raw_author_name: Julien Edeline
raw_affiliation_strings: Medical Oncology Department, Centre Eugene Marquis, Rennes, France
raw_author_name: Luca Fabris
raw_affiliation_strings: Department of Internal Medicine, Digestive Disease Section, Yale University, New Haven, CT, USA
Department of Medicine, School of Medicine, University-Hospital of Padua, Padua, Italy
raw_author_name: Trine Folseraas
raw_affiliation_strings: Norwegian PSC Research Center and Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway
raw_author_name: Alejandro Forner
raw_affiliation_strings: Liver Oncology Unit (BCLC group), Liver Unit, ICMDM, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Benjamin Goeppert
raw_affiliation_strings: Institute of Pathology, RKH Klinikum, Ludwigsburg, Germany
Institute of Tissue Medicine and Pathology (ITMP), University Bern, Bern, Switzerland
raw_author_name: Mathias Heikenwalder
raw_affiliation_strings: Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
M3 Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, University of Tübingen, Tübingen, Germany
raw_author_name: Timothy J. Kendall
raw_affiliation_strings: Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK
raw_author_name: Shahid A. Khan
raw_affiliation_strings: Department of Hepatology, Imperial College Healthcare NHS Trust, London, UK
raw_author_name: Heinz-Josef Klümpen
raw_affiliation_strings: Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands
raw_author_name: Bas Groot Koerkamp
raw_affiliation_strings: Erasmus MC, Department of Surgery, Rotterdam, The Netherlands
raw_author_name: Angela Lamarca
raw_affiliation_strings: Department of Oncology - OncoHealth Institute - Instituto de Investigaciones Sanitarias FJD, Fundación Jiménez Díaz University Hospital, Madrid, Spain
Department of Oncology – OncoHealth Institute – Instituto de Investigaciones Sanitarias FJD, Fundación Jiménez Díaz University Hospital, Madrid, Spain
raw_author_name: Stacie Lindsey
raw_affiliation_strings: Cholangiocarcinoma Foundation, Salt Lake City, UT, USA
raw_author_name: Ana Lleo
raw_affiliation_strings: Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
Division of Internal Medicine and Hepatology, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
raw_author_name: Tom Luedde
raw_affiliation_strings: Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty of Heinrich Heine University Duesseldorf, Duesseldorf, Germany
raw_author_name: Rocio I. R. Macias
raw_affiliation_strings: Experimental Hepatology and Drug Targeting (HEVEPHARM), Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Helen Morement
raw_affiliation_strings: AMMF, The Cholangiocarcinoma Charity, Essex, UK
raw_author_name: Jean-Charles Nault
raw_affiliation_strings: Cordeliers Research Center, Sorbonne Université, Inserm, Université de Paris, Team «Functional Genomics of Solid Tumours», Equipe labellisée Ligue Nationale Contre le Cancer, Labex OncoImmunology, Paris, France
Liver Unit, Avicenne Hospital, APHP, Paris Nord University, Bobigny, France
raw_author_name: Paula Olaizola
raw_affiliation_strings: MRC Human Genetics Unit, Institute of Genetics and Cancer, Edinburgh, UK
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Maria J. Perugorria
raw_affiliation_strings: Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain
Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), San Sebastian, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Chiara Raggi
raw_affiliation_strings: Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
raw_author_name: Lorenza Rimassa
raw_affiliation_strings: Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
raw_author_name: Anna Saborowski
raw_affiliation_strings: Department of Gastroenterology, Hepatology, Infectiology and Endocrinology, Hannover Medical School, Hannover, Germany
raw_author_name: Juan W. Valle
raw_affiliation_strings: Cholangiocarcinoma Foundation, Salt Lake City, UT, USA
Division of Cancer Sciences, University of Manchester, Manchester, UK
raw_author_name: Mathew Vithayathil
raw_affiliation_strings: Department of Surgery and Cancer, Imperial College London, London, UK
raw_author_name: Arndt Vogel
raw_affiliation_strings: Department of Gastroenterology, Hepatology, Infectiology and Endocrinology, Hannover Medical School, Hannover, Germany
Division of Gastroenterology and Hepatology, Toronto General Hospital, Toronto, Ontario, Canada
Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
raw_author_name: Chiara Braconi
raw_affiliation_strings: Beatson West of Scotland Cancer Centre, Glasgow, UK
CRUK Scotland Cancer Centre, Glasgow, UK
School of Cancer Sciences, University of Glasgow, Glasgow, UK
raw_author_name: Abel Sanchez
raw_affiliation_strings: San Carlos University, Antígua, Guatemala
raw_author_name: Adelaida La Casta
raw_affiliation_strings: Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute – Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain
raw_author_name: Aldo J. Montano-Loza
raw_affiliation_strings: University of Alberta, Edmonton, Alberta, Canada
raw_author_name: Alessandra Elvevi
raw_affiliation_strings: Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
raw_author_name: Alessandro Parisi
raw_affiliation_strings: Clinica Oncologica e Centro Regionale di Genetica Oncologica, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy
raw_author_name: Alexander Link
raw_affiliation_strings: Friedrich-Alexander University Erlangen-Nuernberg (FAU), Medical Campus Upper Franconia, Bayreuth, Germany
raw_author_name: Ana Landa-Magdalena
raw_affiliation_strings: Liver Unit, Cancer Center Clínica Universidad de Navarra, Pamplona, Spain
raw_author_name: Andres Munoz
raw_affiliation_strings: Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain
raw_author_name: Anthony Turpin
raw_affiliation_strings: Lille University Hospital, University of Lille, Lille, France
raw_author_name: Anu Ustav
raw_affiliation_strings: Tartu University, Tartu, Estonia
raw_author_name: Apinya Jusakul
raw_affiliation_strings: Faculty of Associated Medical Sciences, Khon Kaen University, Chiang Mai, Thailand
raw_author_name: Arun Valsan
raw_affiliation_strings: Amrita Institute of Medical Sciences, Kochi, India
raw_author_name: Benjamin Dwyer
raw_affiliation_strings: Curtin University and Liver Cancer Collaborative, Perth, Western Australia, Australia
raw_author_name: Bogdan S. Ungureanu
raw_affiliation_strings: Gastroenterology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
raw_author_name: Bruno Sangro
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National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Christoph Schramm
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raw_author_name: Cindy Neuzillet
raw_affiliation_strings: Université Versailles Saint-Quentin-Université, Institut Curie, Saint-Cloud and Ambroise Paré University Hospital, AP-HP, Boulogne-Billancourt, France
raw_author_name: Constantino Fondevila
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raw_author_name: David J. Pinato
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raw_author_name: David Malka
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raw_author_name: Domingo Balderramo
raw_affiliation_strings: Hospital Privado Universitario de Córdoba, Córdoba, Argentina
raw_author_name: Elide Gutierrez
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raw_author_name: Elisa Lozano
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National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Emmanuel Boleslawski
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raw_author_name: Enrique Carrera Estupinan
raw_affiliation_strings: Hospital Eugenio Espejo, Quito, Ecuador
raw_author_name: Ernesto Sparrelid
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raw_author_name: Eugenio Gaudio
raw_affiliation_strings: Department of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy
raw_author_name: Fatima Higuera De La Tijera
raw_affiliation_strings: Hospital General de México, Mexico City, Mexico
raw_author_name: Flavio Rocha
raw_affiliation_strings: Oregon Health & Science University (OHSU), Portland, OR, USA
raw_author_name: Florence Troisfontaine
raw_affiliation_strings: CHU Liège, Liège, Belgium
raw_author_name: Francesca Ratti
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raw_author_name: Frank Lammert
raw_affiliation_strings: Center for Health Economics Research Hannover (CHERH), Hannover Medical School (MHH), Hannover, Germany
raw_author_name: Gianpaolo Vidili
raw_affiliation_strings: University of Sassari, Sassari, Italy
raw_author_name: Gonzalo Sapisochin
raw_affiliation_strings: Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
raw_author_name: Gregory B. Lesinski
raw_affiliation_strings: Emory University School of Medicine, Atlanta, GA, USA
raw_author_name: Gregory Gores
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raw_author_name: Hannes Jansson
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raw_author_name: Hassan Malik
raw_affiliation_strings: Royal Liverpool University hospital, Liverpool, UK
raw_author_name: Jan Philipp Jonas
raw_affiliation_strings: University Hospital Zurich and University of Zurich, Zurich, Switzerland
raw_author_name: Javier Diaz Ferrer
raw_affiliation_strings: Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
raw_author_name: Javier Vaquero
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raw_author_name: Jens U. Marquardt
raw_affiliation_strings: University Medical Center Schleswig Holstein Campus Lübeck, Lübeck, Germany
raw_author_name: Joana Espírito Santo
raw_affiliation_strings: Coimbra Hospital and University Centre, Coimbra, Portugal
raw_author_name: Jorge Adeva
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raw_author_name: Joris Erdmann
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raw_author_name: Jose J. G. Marin
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National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Juan Carlos Roa
raw_affiliation_strings: Universidad de Chile and Pontificia Universidad Católica de Chile, Santiago de Chile, Chile
raw_author_name: Juli Busquets
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Hospital Universitari de Bellvitge, Research Group of Hepato-Biliary and Pancreatic Diseases, Bellvitge, Biomedical Research Institute (IDIBELL), Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain
raw_author_name: Juozas Kupcinskas
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Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
raw_author_name: Krzysztof Zieniewicz
raw_affiliation_strings: Medical University of Warsaw, Warsaw, Poland
raw_author_name: Lara Heij
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raw_author_name: Laura Goff
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raw_author_name: Laura Izquierdo-Sanchez
raw_affiliation_strings: Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute – Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain
National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Leonardo G. Da Fonseca
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raw_author_name: Luca Maroni
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raw_author_name: Luis Bujanda
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National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain
raw_author_name: Mairéad G. McNamara
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raw_author_name: Marco Carbone
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raw_author_name: Marco Marzioni
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raw_author_name: Marco Rengo
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raw_author_name: Maria Melanie Deutsch
raw_affiliation_strings: National and Kapodistrian University of Athens, Athens, Greece