Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
Year: 2025
Type: article
Language: en
Topic: Glioma Diagnosis and Treatment
Authors and affiliations:
raw_author_name: Martin Sill
raw_affiliation_strings: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address: m.sill@kitz-heidelberg.de
raw_author_name: Daniel Schrimpf
raw_affiliation_strings: Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Areeba Patel
raw_affiliation_strings: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Dominik Sturm
raw_affiliation_strings: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Natalie Jäger
raw_affiliation_strings: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Philipp Sievers
raw_affiliation_strings: Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Leonille Schweizer
raw_affiliation_strings: Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany
raw_author_name: Rouzbeh Banan
raw_affiliation_strings: Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: David Reuss
raw_affiliation_strings: Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Abigail Suwala
raw_affiliation_strings: Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Andrey Korshunov
raw_affiliation_strings: Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Damian Stichel
raw_affiliation_strings: Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Annika K. Wefers
raw_affiliation_strings: Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
raw_author_name: Ann-Christin Hau
raw_affiliation_strings: Translational Neuro-Oncology Group, Dr. Senckenbergisches Institute for Neurooncology and Institute of Neurology (Edinger Institute), University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
raw_author_name: Henning Boldt
raw_affiliation_strings: Department of Pathology, Odense University Hospital, Odense, Denmark
raw_author_name: Patrick N. Harter
raw_affiliation_strings: Bavarian Cancer Research Center (BZKF), Partner Site Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between DKFZ and University/University Hospital, LMU Munich, Munich, Germany; Center for Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Munich, Germany
raw_author_name: Zied Abdullaev
raw_affiliation_strings: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
raw_author_name: Jamal Benhamida
raw_affiliation_strings: Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA
raw_author_name: Daniel Teichmann
raw_affiliation_strings: Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Arend Koch
raw_affiliation_strings: Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Jürgen Hench
raw_affiliation_strings: Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland
raw_author_name: Stephan Frank
raw_affiliation_strings: Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland
raw_author_name: Martin Hasselblatt
raw_affiliation_strings: Institute of Neuropathology, University Hospital Münster, Münster, Germany
raw_author_name: Sheila Mansouri
raw_affiliation_strings: Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada
raw_author_name: Theresita Díaz de Ståhl
raw_affiliation_strings: Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
raw_author_name: Jonathan Serrano
raw_affiliation_strings: Department of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, NY, USA
raw_author_name: Jonas Ecker
raw_affiliation_strings: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; KiTZ Clinical Trial Unit, Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
raw_author_name: Florian Selt
raw_affiliation_strings: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany
raw_author_name: Michael Taylor
raw_affiliation_strings: Department of Pediatrics- Hematology/Oncology, and Neurosurgery, Texas Children's Cancer Center, Hematology-Oncology Section, Baylor College of Medicine, Houston, TX, USA
raw_author_name: Vijay Ramaswamy
raw_affiliation_strings: The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON, Canada; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
raw_author_name: Florence Cavalli
raw_affiliation_strings: Institut Curie, PSL Research University, Paris, France; Inserm, U900, Paris, France; MINES ParisTech, CBIO, Centre for Computational Biology, PSL Research University, 75006 Paris, France
raw_author_name: Anna S. Berghoff
raw_affiliation_strings: Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
raw_author_name: Brigitte Bison
raw_affiliation_strings: Department of Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany
raw_author_name: Mirjam Blattner-Johnson
raw_affiliation_strings: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Ivo Buchhalter
raw_affiliation_strings: Omics IT and Data Management Core Facility, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
raw_author_name: Rolf Buslei
raw_affiliation_strings: Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany
raw_author_name: Gabriele Calaminus
raw_affiliation_strings: Department of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany
raw_author_name: Nicola Dikow
raw_affiliation_strings: Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany
raw_author_name: Hildegard Dohmen
raw_affiliation_strings: Institute of Neuropathology, University of Giessen, Giessen, Germany
raw_author_name: Philipp Euskirchen
raw_affiliation_strings: Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany
raw_author_name: Gudrun Fleischhack
raw_affiliation_strings: Pediatrics III, University Hospital Essen, Essen, Germany
raw_author_name: Amar Gajjar
raw_affiliation_strings: Division of Neuro Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA
raw_author_name: Nicolas U. Gerber
raw_affiliation_strings: Department of Oncology, University Children's Hospital, Zurich, Switzerland
raw_author_name: Marco Gessi
raw_affiliation_strings: Department of Life Sciences and Public Health, Università Cattolica Sacro Cuore, Rome, Italy
raw_author_name: Gerrit H. Gielen
raw_affiliation_strings: Department of Neuropathology, University Hospital Bonn, Bonn, Germany
raw_author_name: Astrid Gnekow
raw_affiliation_strings: Swabian Children's Cancer Center, Pediatric and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
raw_author_name: Nicholas G. Gottardo
raw_affiliation_strings: Department of Pediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, WA, Australia; Centre for Child Health Research, University of Western Australia, Nedlands, WA, Australia; Brain Tumour Research Program, Telethon Kids Institute, Nedlands, WA, Australia
raw_author_name: Christine Haberler
raw_affiliation_strings: Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria
raw_author_name: Stefan Hamelmann
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raw_author_name: Volkmar Hans
raw_affiliation_strings: Department of Neuropathology, Institute for Clinical Pathology, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg, Germany
raw_author_name: Jordan R. Hansford
raw_affiliation_strings: Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australia Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, Australia
raw_author_name: Christian Hartmann
raw_affiliation_strings: Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover, Germany
raw_author_name: Frank L. Heppner
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raw_author_name: Pablo Hernaiz Driever
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raw_author_name: Katja von Hoff
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raw_author_name: Ulrich W. Thomale
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raw_author_name: Stephan Tippelt
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raw_author_name: Michael C. Frühwald
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raw_author_name: Christof M. Kramm
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raw_author_name: Ulrich Schüller
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raw_author_name: Jens Schittenhelm
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raw_author_name: Martin U. Schuhmann
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raw_author_name: Marco Stein
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raw_author_name: Petra Ketteler
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raw_author_name: Marc Ladanyi
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raw_author_name: Nada Jabado
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raw_author_name: Barbara C. Jones
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raw_author_name: Chris Jones
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raw_author_name: Matthias A. Karajannis
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raw_author_name: Ralf Ketter
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raw_author_name: Patricia Kohlhof
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raw_author_name: Uwe Kordes
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raw_author_name: Annekathrin Reinhardt
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raw_author_name: Christian Kölsche
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raw_author_name: Katrin Lamszus
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raw_author_name: Sybren L.N. Maas
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raw_author_name: Christian Mawrin
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raw_author_name: Till Milde
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raw_author_name: Michel Mittelbronn
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raw_author_name: Camelia-Maria Monoranu
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raw_author_name: Wolf Mueller
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raw_author_name: Martin Mynarek
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raw_author_name: Paul A. Northcott
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raw_author_name: Kristian W. Pajtler
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raw_author_name: Werner Paulus
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raw_author_name: Arie Perry
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raw_author_name: Ingmar Blümcke
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raw_author_name: Karl H. Plate
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raw_author_name: Michael Platten
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raw_author_name: Matthias Preusser
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raw_author_name: Torsten Pietsch
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raw_author_name: Marco Prinz
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raw_author_name: Guido Reifenberger
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raw_author_name: Bjarne W. Kristensen
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raw_author_name: Marcel Kool
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raw_author_name: Thomas S. Jacques
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raw_author_name: Pascale Varlet
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