Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension
Year: 2025
Type: article
Language: en
Topic: RNA regulation and disease
Authors and affiliations:
raw_author_name: Chen-Shan Chen Woodcock
raw_affiliation_strings: Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.C.W., T.L., A.L.M.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.-S.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.-S.C.W., T.L., A.L.M.C.)
raw_author_name: Giovanni Maroli
raw_affiliation_strings: Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, Germany (G.M., S.S.P.)
Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI) Bad Nauheim, Germany (G.M., S.S.P.)
raw_author_name: Hyunbum Kim
raw_affiliation_strings: Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.)
Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.)
raw_author_name: Yi Yin Tai
raw_affiliation_strings: Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.-S.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
raw_author_name: Ying Tang
raw_affiliation_strings: Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.-S.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
raw_author_name: Satoshi Okawa
raw_affiliation_strings: Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA (S.O., S.C.)
McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, PA (S.O.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA (S.O., S.-T.C.)
raw_author_name: Rami Homsi
raw_affiliation_strings: Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
raw_author_name: Yunhye Kim
raw_affiliation_strings: Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.)
Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.)
raw_author_name: Shu-Ting Cho
raw_affiliation_strings: Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA (S.O., S.C.)
Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA (S.O., S.-T.C.)
raw_author_name: Siyi Jiang
raw_affiliation_strings: Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
raw_author_name: Caroline Chauvet
raw_affiliation_strings: Université Côte d’Azur, CNRS, IPMC, Valbonne, France (C.C., T.B.)
raw_author_name: Bing Wang
raw_affiliation_strings: Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.-S.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
raw_author_name: Yassmin Al Aaraj
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Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.-S.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
raw_author_name: Robert Lafyatis
raw_affiliation_strings: Division of Rheumatology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA (R.L.)
raw_author_name: Rajan Saggar
raw_affiliation_strings: Division of Pulmonary, Critical Care, Sleep Medicine, Clinical Immunology and Allergy, David Geffen School of Medicine at UCLA, Los Angeles, CA (R.S.)
raw_author_name: John Sembrat
raw_affiliation_strings: Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, PA (J.S., S.M.N.)
raw_author_name: Qingde Wang
raw_affiliation_strings: Department of Surgery, University of Pittsburgh School of Medicine, PA (Q.W.)
raw_author_name: Qin Li
raw_affiliation_strings: Department of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (Q.L.)
raw_author_name: Andrea L. Frump
raw_affiliation_strings: Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN (A.L.F.)
raw_author_name: Tim Lahm
raw_affiliation_strings: Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO (T.L., A.L.M.)
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.C.W., T.L., A.L.M.)
Lung Center, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis School of Medicine, Sacramento, CA (E.A.G.)
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.-S.C.W., T.L., A.L.M.C.)
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO (T.L., A.L.M.C.)
Rocky Mountain Regional VA Medical Center, Aurora, CO (T.L.)
raw_author_name: Alexandra L. McCubbrey
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Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.C.W., T.L., A.L.M.)
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.-S.C.W., T.L., A.L.M.C.)
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO (T.L., A.L.M.C.)
raw_author_name: Tatiana V. Kudryashova
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Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.-S.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
raw_author_name: Elena A. Goncharova
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raw_author_name: Seyed Mehdi Nouraie
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raw_author_name: Thomas Bertero
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raw_author_name: Ke Yuan
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Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.)
raw_author_name: Soni S. Pullamsetti
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Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI) Bad Nauheim, Germany (G.M., S.S.P.)
raw_author_name: Stephen Y. Chan
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Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.-S.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.)
Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (C.-S.C.W., Y.Y.T., Y.T., B.W., Y.A.A., T.V.K., S.Y.C.)