A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells
Year: 2025
Type: article
Language: en
Topic: Cancer-related gene regulation
Authors and affiliations:
raw_author_name: Elisabeth M. Rothweiler
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Ani Michaud
raw_affiliation_strings: Promega Corporation, Madison, WI, USA
raw_author_name: Jakub Stefaniak
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Usha Singh
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Brynwood B. Mikulsky
raw_affiliation_strings: Promega Corporation, Madison, WI, USA
raw_author_name: James D. Vasta
raw_affiliation_strings: Promega Corporation, Madison, WI, USA
raw_author_name: Michael T. Beck
raw_affiliation_strings: Promega Corporation, Madison, WI, USA
raw_author_name: Jennifer Wilkinson
raw_affiliation_strings: Promega Corporation, Madison, WI, USA
raw_author_name: Jennifer A. Ward
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Catherine M. Rogers
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Esra Balıkçı
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Jeppe Tranberg-Jensen
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Jesper S. Hansen
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Peter Loppnau
raw_affiliation_strings: Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada
raw_author_name: Adrian Whitty
raw_affiliation_strings: Department of Chemistry, Boston University, Boston, MA, USA
raw_author_name: Paul E. Brennan
raw_affiliation_strings: Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
raw_author_name: Peter J. Tonge
raw_affiliation_strings: Center for Advanced Study of Drug Action, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA. peter.tonge@stonybrook.edu
Department of Biomedical Genetics, University of Rochester, Rochester, NY, USA. peter.tonge@stonybrook.edu
Department of Biomedical Genetics, University of Rochester, Rochester, NY, USA
Center for Advanced Study of Drug Action, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA
raw_author_name: Matthew B. Robers
raw_affiliation_strings: Promega Corporation, Madison, WI, USA. matt.robers@promega.com
Promega Corporation, Madison, WI, USA
raw_author_name: Kilian V. M. Huber
raw_affiliation_strings: Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk
Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK