FLT3-directed BiTE molecules vs CAR T cells in AML: costimulatory signals mitigate T-cell exhaustion
Year: 2025
Type: article
Language: en
Topic: CAR-T cell therapy research
Authors and affiliations:
raw_author_name: Lisa Rohrbacher
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Daniel Nixdorf
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Helena Stadler
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Bettina Brauchle
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
Klinikum der LMU München, München, Germany
raw_author_name: Florian Märkl
raw_affiliation_strings: 3Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University Munich, Member of the German Center for Lung Research, Munich, Germany
Klinikum der Universität München, Munich, Germany
raw_author_name: Adrian Gottschlich
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
3Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University Munich, Member of the German Center for Lung Research, Munich, Germany
4German Cancer Consortium, Partner Site Munich and German Cancer Research Center, Heidelberg, Germany
5Bavarian Cancer Research Center, Munich, Germany
Klinikum der Universität München, Munich, Germany
raw_author_name: Gordon V. Hoffmann
raw_affiliation_strings: 3Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University Munich, Member of the German Center for Lung Research, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Nora Philipp
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Gerulf Hänel
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital LMU Munich, Munich, Germany
raw_author_name: Martin E. Kirmaier
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
4German Cancer Consortium, Partner Site Munich and German Cancer Research Center, Heidelberg, Germany
6Cancer and Immunometabolism Research Group, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Anetta Marcinek
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
Klinikum der LMU München, Munich, Germany
raw_author_name: Maryam Kazerani
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
LMU University Hospital, LMU Munich, Munich, Germany
raw_author_name: Daniel Richter
raw_affiliation_strings: 7Anthropology and Human Genomics, Faculty of Biology, Ludwig Maximilian University Munich, Munich, Germany
LMU Munich, Martinsried, Germany
raw_author_name: Giulia Magno
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
Department of Medicine III, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany
raw_author_name: Rebecca L. Goldstein
raw_affiliation_strings: 8Amgen Research, Amgen Inc, South San Francisco, CA
Amgen, Inc., South San Francisco, California, United States
raw_author_name: Sebastian Theurich
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
4German Cancer Consortium, Partner Site Munich and German Cancer Research Center, Heidelberg, Germany
5Bavarian Cancer Research Center, Munich, Germany
6Cancer and Immunometabolism Research Group, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Tobias Straub
raw_affiliation_strings: 9Core Facility Bioinformatics, Biomedical Center, Ludwig Maximilian University Munich, Munich, Germany
Core Facility Bioinformatics, Biomedical Center, LMU, Planegg-Martinsried, Cote d' Ivoire
raw_author_name: Sebastian Kobold
raw_affiliation_strings: 10Einheit für Klinische Pharmakologie, Helmholtz Munich, Research Center for Environmental Health, Neuherberg, Germany
3Division of Clinical Pharmacology, University Hospital, Ludwig Maximilian University Munich, Member of the German Center for Lung Research, Munich, Germany
4German Cancer Consortium, Partner Site Munich and German Cancer Research Center, Heidelberg, Germany
Klinikum der Universität München, Munich, Germany
raw_author_name: Tara Arvedson
raw_affiliation_strings: 8Amgen Research, Amgen Inc, South San Francisco, CA
Hexagon Bio, Menlo Park, California, United States
raw_author_name: Veit Bücklein
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
University Hospital, LMU Munich, Munich, Germany
raw_author_name: Marion Subklewe
raw_affiliation_strings: 1Department of Medicine III, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
2Laboratory for Translational Cancer Immunology, Gene Center, Ludwig Maximilian University Munich, Munich, Germany
4German Cancer Consortium, Partner Site Munich and German Cancer Research Center, Heidelberg, Germany
5Bavarian Cancer Research Center, Munich, Germany
University Hospital, LMU Munich, Munich, Germany