Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk
Year: 2025
Type: article
Language: en
Topic: Genetic Associations and Epidemiology
Authors and affiliations:
raw_author_name: Shinwan Kany
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Department of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
Department of Cardiology, University Heart and Vascular Center Hamburg–Eppendorf, Hamburg, Germany
raw_author_name: Joel T. Rämö
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
raw_author_name: Cody Hou
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
University of Minnesota Medical School, Minneapolis, MN, USA
raw_author_name: Sean J. Jurgens
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Center, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands
raw_author_name: Shaan Khurshid
raw_affiliation_strings: Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Victor Nauffal
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA
raw_author_name: Jonathan W. Cunningham
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA
raw_author_name: Emily S. Lau
raw_affiliation_strings: Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
raw_author_name: Satoshi Koyama
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
raw_author_name: FinnGen
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
raw_author_name: Jennifer E. Ho
raw_affiliation_strings: Cardiology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA
raw_author_name: Jeffrey E. Olgin
raw_affiliation_strings: Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA
raw_author_name: Sammy Elmariah
raw_affiliation_strings: Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
raw_author_name: Aarno Palotie
raw_affiliation_strings: Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Mark E. Lindsay
raw_affiliation_strings: Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Thoracic Aortic Center, Massachusetts General Hospital, Boston, MA, USA
Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA
raw_author_name: Patrick T. Ellinor
raw_affiliation_strings: Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA
Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA
raw_author_name: James P. Pirruccello
raw_affiliation_strings: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. james.pirruccello@ucsf.edu
Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA. james.pirruccello@ucsf.edu
Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. james.pirruccello@ucsf.edu