Hydrazonylthiazole Derivatives as Dual EGFR and ALR2 Inhibitors: Design, Synthesis, and Comprehensive In Vitro and In Silico Evaluation for Potential Anticancer Activity
Year: 2025
Type: article
Language: en
Topic: Aldose Reductase and Taurine
Authors and affiliations:
raw_author_name: Belgin Sever
raw_affiliation_strings: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Türkiye
Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan
raw_author_name: Cüneyt Türkeş
raw_affiliation_strings: Department of Biochemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan 24100, Türkiye
raw_author_name: Yeliz Demir
raw_affiliation_strings: Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, Ardahan 75700, Türkiye
raw_author_name: Khaled M. Elamin
raw_affiliation_strings: Global Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
raw_author_name: Wadah Osman
raw_affiliation_strings: Department of Pharmacognosy, Faculty of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
raw_author_name: Kübra Oral
raw_affiliation_strings: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Türkiye
raw_author_name: Selenay Akıncı Genç
raw_affiliation_strings: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Türkiye
raw_author_name: Zerrin Cantürk
raw_affiliation_strings: Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Türkiye
raw_author_name: Takuya Masunaga
raw_affiliation_strings: Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan
raw_author_name: Naoki Kishimoto
raw_affiliation_strings: Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
Global Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
raw_author_name: Shogo Misumi
raw_affiliation_strings: Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
Global Center for Natural Products Research, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
raw_author_name: Masami Otsuka
raw_affiliation_strings: Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan
Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan
raw_author_name: Mikako Fujita
raw_affiliation_strings: Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan
raw_author_name: Halilibrahim Ciftci
raw_affiliation_strings: Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan
Department of Molecular Biology and Genetics, Burdur Mehmet Akif Ersoy University, Istiklal Campus, Burdur 15200, Türkiye
Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan