Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease
Year: 2025
Type: article
Language: en
Topic: Neuroinflammation and Neurodegeneration Mechanisms
Authors and affiliations:
raw_author_name: Tanya N. Weerakkody
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Hanna Sabelström
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Shan V. Andrews
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Jean Paul Chadarevian
raw_affiliation_strings: Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA
Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA
raw_author_name: Marcus Y. Chin
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: David Tatarakis
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Nicholas E. Propson
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Do Jin Kim
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Richard Theolis
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Gian Carlo G. Parico
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Hiwot Misker
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Jennifer E. Kung
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Abira Bandyopadhyay
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Yaneth Robles Colmenares
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Taggra-Nicole Jackson
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Ahlam N. Qerqez
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Srijana Balasundar
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Sonnet S. Davis
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Connie Ha
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Rajarshi Ghosh
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Ritesh Ravi
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Anil Rana
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Kyla Germain
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Arnold Tao
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Ken Xiong
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Dylan Braun
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Karthik Raju
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Kang-Chieh Huang
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Lihong Zhan
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Jing L. Guo
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Hoda Safari Yazd
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Lily Sarrafha
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Joia Kai Capocchi
raw_affiliation_strings: Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
raw_author_name: Jonathan Hasselmann
raw_affiliation_strings: Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA
raw_author_name: Alina L. Chadarevian
raw_affiliation_strings: Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA
Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA
raw_author_name: Christina Tu
raw_affiliation_strings: Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA
raw_author_name: Kimiya Mansour
raw_affiliation_strings: Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
raw_author_name: Ghazaleh Eskandari-Sedighi
raw_affiliation_strings: Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA
raw_author_name: Niccolò Tesi
raw_affiliation_strings: Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 2, 2628CD Delft, Netherlands
Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
raw_author_name: Sven van der Lee
raw_affiliation_strings: Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
raw_author_name: Marc Hulsman
raw_affiliation_strings: Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
raw_author_name: Georgii Oshegov
raw_affiliation_strings: Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
raw_author_name: Yolande Pijnenburg
raw_affiliation_strings: Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
raw_author_name: Meredith Calvert
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Henne Holstege
raw_affiliation_strings: Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
Delft Bioinformatics Lab, Delft University of Technology, Mekelweg 2, 2628CD Delft, Netherlands
Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081HV Amsterdam, Netherlands
raw_author_name: Jung H. Suh
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Gilbert Di Paolo
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Hayk Davtyan
raw_affiliation_strings: Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA
raw_author_name: Joseph W. Lewcock
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA
raw_author_name: Mathew Blurton-Jones
raw_affiliation_strings: Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 USA
Institute for Memory Impairments and Neurological Disorders, Irvine, CA 92697 USA
Sue and Bill Gross Stem Cell Research Center, Irvine, CA 92697 USA
raw_author_name: Kathryn M. Monroe
raw_affiliation_strings: Denali Therapeutics Inc., South San Francisco, CA 94080 USA