Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s disease
Year: 2025
Type: article
Language: en
Topic: Alzheimer's disease research and treatments
Authors and affiliations:
raw_author_name: Andi Liu
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Citu Citu
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Nitesh Enduru
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Xian Chen
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Chia-Hao Tung
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Tirthankar Sinha
raw_affiliation_strings: Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Sofia E. Sepulveda
raw_affiliation_strings: Department of Neurology, McGovern School of Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Astrid M. Manuel
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Damian Gorski
raw_affiliation_strings: Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Brisa S. Fernandes
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Meifang Yu
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Paul E. Schulz
raw_affiliation_strings: Department of Neurology, McGovern School of Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Lukas M. Simon
raw_affiliation_strings: Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX 77030, USA
raw_author_name: Claudio Soto
raw_affiliation_strings: Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
raw_author_name: Zhongming Zhao
raw_affiliation_strings: Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA