Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139
Year: 2025
Type: article
Language: en
Topic: Receptor Mechanisms and Signaling
Authors and affiliations:
raw_author_name: Israel Cabeza de Vaca
raw_affiliation_strings: Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
raw_author_name: Boris Trapkov
raw_affiliation_strings: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Ling Shen
raw_affiliation_strings: iHuman Institute, ShanghaiTech University, Shanghai, China
raw_author_name: Duy Duc Vo
raw_affiliation_strings: Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
raw_author_name: Xiaoqun Zhang
raw_affiliation_strings: Neuro Svenningsson, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
School of Life Science and Technology, ShanghaiTech University, Shanghai, China
iHuman Institute, ShanghaiTech University, Shanghai, China
raw_author_name: Yunting Yang
raw_affiliation_strings: Neuro Svenningsson, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
raw_author_name: Mitra Pezeshki
raw_affiliation_strings: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Xuehan Zhang
raw_affiliation_strings: Neuro Svenningsson, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
School of Life Science and Technology, ShanghaiTech University, Shanghai, China
iHuman Institute, ShanghaiTech University, Shanghai, China
raw_author_name: Frida Bällgren
raw_affiliation_strings: Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden
raw_author_name: Aljona Saleh
raw_affiliation_strings: Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden
raw_author_name: Andrii V. Tarnovskiy
raw_affiliation_strings: Enamine Ltd., Kyiv, Ukraine
raw_author_name: Dmytro S. Radchenko
raw_affiliation_strings: Enamine Ltd., Kyiv, Ukraine
raw_author_name: Yurii S. Moroz
raw_affiliation_strings: Chemspace LLC, Kyiv, Ukraine
Enamine Ltd., Kyiv, Ukraine
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
raw_author_name: Hans Bräuner-Osborne
raw_affiliation_strings: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Per Svenningsson
raw_affiliation_strings: Neuro Svenningsson, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
raw_author_name: Jan Kihlberg
raw_affiliation_strings: Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden
raw_author_name: Zhi-Jie Liu
raw_affiliation_strings: School of Life Science and Technology, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn
iHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn
iHuman Institute, ShanghaiTech University, Shanghai, China
raw_author_name: Alexander Sebastian Hauser
raw_affiliation_strings: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. alexander.hauser@sund.ku.dk
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
raw_author_name: Jens Carlsson
raw_affiliation_strings: Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. jens.carlsson@icm.uu.se
Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden