Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control
Year: 2025
Type: article
Language: en
Topic: Gut microbiota and health
Authors and affiliations:
raw_author_name: Julien Chilloux
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Francois Brial
raw_affiliation_strings: University Paris Cité, INSERM U1132, Biologie de l'os et du cartilage (BIOSCAR), Paris, France
raw_author_name: Amandine Everard
raw_affiliation_strings: Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium
raw_author_name: David Smyth
raw_affiliation_strings: University of Ottawa Heart Institute, Ottawa, Ontario, Canada
raw_author_name: Petros Andrikopoulos
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Liyong Zhang
raw_affiliation_strings: University of Ottawa Heart Institute, Ottawa, Ontario, Canada
raw_author_name: Hubert Plovier
raw_affiliation_strings: Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium
raw_author_name: Antonis Myridakis
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Lesley Hoyles
raw_affiliation_strings: Department of Biosciences, Nottingham Trent University, Clifton Campus, Nottingham, UK
Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: José Maria Moreno-Navarrete
raw_affiliation_strings: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
Department of Endocrinology, Diabetes and Nutrition, University Hospital of Girona 'Dr Josep Trueta', Girona, Spain
Institut d'Investigació Biomèdica de Girona (IdibGi), Girona, Spain
raw_author_name: Jèssica Latorre Luque
raw_affiliation_strings: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
Department of Endocrinology, Diabetes and Nutrition, University Hospital of Girona 'Dr Josep Trueta', Girona, Spain
Institut d'Investigació Biomèdica de Girona (IdibGi), Girona, Spain
raw_author_name: Viviana Casagrande
raw_affiliation_strings: Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, Rome, Italy
raw_author_name: Rossella Menghini
raw_affiliation_strings: Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, Rome, Italy
raw_author_name: Blerina Ahmetaj-Shala
raw_affiliation_strings: Section of Cardio-Respiratory Interface, National Heart & Lung Institute, Imperial College London, London, UK
raw_author_name: Christine Blancher
raw_affiliation_strings: Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
raw_author_name: Laura Martinez-Gili
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Selin Gencer
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Jane F. Fearnside
raw_affiliation_strings: Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
raw_author_name: Richard H. Barton
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Ana Luisa Neves
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Alice R. Rothwell
raw_affiliation_strings: Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
raw_author_name: Christelle Gérard
raw_affiliation_strings: University Paris Cité, Functional and Adaptive Biology, CNRS UMR 8251, Paris, France
raw_author_name: Sophie Calderari
raw_affiliation_strings: University Paris-Saclay, INRAE, Jouy-en-Josas, France
raw_author_name: Mark J. Williamson
raw_affiliation_strings: Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK
raw_author_name: Julian E. Fuchs
raw_affiliation_strings: Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK
raw_author_name: Lata Govada
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Claire L. Boulangé
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Saroor Patel
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: James Scott
raw_affiliation_strings: Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK
raw_author_name: Mark Thursz
raw_affiliation_strings: Section of Hepatology & Gastroenterology, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Naomi Chayen
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Robert C. Glen
raw_affiliation_strings: Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK
Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Nigel J. Gooderham
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
raw_author_name: Jeremy K. Nicholson
raw_affiliation_strings: Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
The Australian National Phenome Centre, Health Futures Institute, Murdoch University, Harry Perkins Institute, Perth, Australia
raw_author_name: Massimo Federici
raw_affiliation_strings: Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, Rome, Italy
raw_author_name: José Manuel Fernández-Real
raw_affiliation_strings: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
Department of Endocrinology, Diabetes and Nutrition, University Hospital of Girona 'Dr Josep Trueta', Girona, Spain
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Institut d'Investigació Biomèdica de Girona (IdibGi), Girona, Spain
raw_author_name: Dominique Gauguier
raw_affiliation_strings: University Paris Cité, Functional and Adaptive Biology, CNRS UMR 8251, Paris, France
Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
raw_author_name: Peter P. Liu
raw_affiliation_strings: University of Ottawa Heart Institute, Ottawa, Ontario, Canada
raw_author_name: Patrice D. Cani
raw_affiliation_strings: Institute of Experimental and Clinical Research (IREC), UCLouvain, Université catholique de Louvain, Brussels, Belgium
Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium
raw_author_name: Marc-Emmanuel Dumas
raw_affiliation_strings: European Genomic Institute for Diabetes, U1283 INSERM, UMR8199 CNRS, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France. m.dumas@imperial.ac.uk
Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.dumas@imperial.ac.uk
Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montreal, Quebec, Canada. m.dumas@imperial.ac.uk
European Genomic Institute for Diabetes, U1283 INSERM, UMR8199 CNRS, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France