L-Proline-catalyzed regioselective C1 arylation of tetrahydroisoquinolines through a multicomponent reaction under solvent-free conditions.
Rahman, Iftakur; Deka, Bhaskar; Thakuria, Ranjit; Deb, Mohit L.; Baruah, Pranjal K.; Organic & biomolecular chemistry 18 (2020) 6514–6518; doi:10.1039/d0ob01363c

data_7157670
_publ_section_title
;
 L-Proline-catalyzed regioselective C1 arylation of
 tetrahydroisoquinolines through a multicomponent reaction under
 solvent-free conditions.
;
_journal_issue                   33
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              6514
_journal_page_last               6518
_journal_paper_doi               10.1039/d0ob01363c
_journal_volume                  18
_journal_year                    2020
_chemical_formula_moiety         'C27 H28 N4'
_chemical_formula_sum            'C27 H28 N4'
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_atom_sites_solution_hydrogens   mixed
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_audit_update_record
;
2020-05-06 deposited with the CCDC.	2020-08-05 downloaded from the CCDC.
;
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_diffrn_source                   'fine-focus sealed tube'
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_refine_ls_R_factor_all          0.1539
_refine_ls_R_factor_gt           0.0611
_refine_ls_shift/su_max          0.006
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0764P)^2^+0.0026P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1400
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_reflns_Friedel_coverage         0.000
_reflns_number_gt                2846
_reflns_number_total             6117
_reflns_threshold_expression     'I > 2\s(I)'
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_cod_data_source_block           IR141
_cod_depositor_comments
'Adding full bibliography for 7157669--7157670.cif.'
_cod_original_cell_volume        2302.5(15)
_cod_original_sg_symbol_H-M      'P 21/c'
_cod_database_code               7157670
_shelx_shelxl_version_number     2016/6
_shelx_estimated_absorpt_t_min   0.987
_shelx_estimated_absorpt_t_max   0.991
_exptl_absorpt_special_details   'Sheldrick,G.M.,2015,University of gottingen'
_shelx_res_checksum              98533
_shelx_hkl_checksum              95443