The antitumour drug 7-ethyl-10-hydroxycamptothecin monohydrate and its solid-state hydrolysis mechanism on heating
Ali, Md. Ashraf; Noguchi, Shuji; Watanabe, Miteki; Iwao, Yasunori; Itai, Shigeru; Acta Crystallographica Section C 72 (2016) 743–747; doi:10.1107/S2053229616014492

data_2020587
_publ_section_title
;
 The antitumour drug 7-ethyl-10-hydroxycamptothecin monohydrate and its
 solid-state hydrolysis mechanism on heating
;
_journal_coeditor_code           YO3022
_journal_issue                   10
_journal_name_full               'Acta Crystallographica Section C'
_journal_page_first              743
_journal_page_last               747
_journal_paper_doi               10.1107/S2053229616014492
_journal_volume                  72
_journal_year                    2016
_chemical_formula_moiety         'C22 H20 N2 O5, H2 O'
_chemical_formula_sum            'C22 H22 N2 O6'
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_chemical_name_common            7-ethyl-10-hydroxycamptothecin
_chemical_name_systematic
;
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]
indolizino[1,2-b]quinoline-3,14(4H,12H)dione
;
_space_group_crystal_system      monoclinic
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_computing_cell_refinement
;
RAPID-AUTO (Rigaku, 1999)
;
_computing_data_collection
;
RAPID-AUTO (Rigaku, 1999)
;
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RAPID-AUTO (Rigaku, 1999)
;
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Mercury (Macrae <i>et al.</i>,  2008)
;
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publCIF (Westrip, 2010)
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SHELXL-2014/7 (Sheldrick, 2015<i>b</i>), <i>SHELXLE</i> (H\"ubschle
<i>et al.</i>,  2011)
;
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;
<i>SHELXT</i> (Sheldrick, 2015<i>a</i>)
;
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'Rigaku Mercury2 four-circle diffractometer with CCD area detector'
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_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w = 1/[\s^2^(Fo^2^)+(0.1000P)^2^] where P=(Fo^2^+2Fc^2^)/3'
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_cod_depositor_comments          'Adding full bibliography for 2020587.cif.'
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