Synthesis of iminoisoindolinones via a cascade of the three-component Ugi reaction, palladium catalyzed isocyanide insertion, hydroxylation and an unexpected rearrangement reaction.
Ren, Zhi-Lin; He, Ping; Lu, Wen-Ting; Sun, Mei; Ding, Ming-Wu; Organic & biomolecular chemistry 16 (2018) 6322–6331; doi:10.1039/c8ob01728j

data_7156375
_publ_section_title
;
 Synthesis of iminoisoindolinones via a cascade of the three-component Ugi
 reaction, palladium catalyzed isocyanide insertion, hydroxylation and an
 unexpected rearrangement reaction.
;
_journal_issue                   34
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              6322
_journal_page_last               6331
_journal_paper_doi               10.1039/c8ob01728j
_journal_volume                  16
_journal_year                    2018
_chemical_formula_moiety         'C23 H28 Cl N3 O2'
_chemical_formula_sum            'C23 H28 Cl N3 O2'
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_space_group_crystal_system      monoclinic
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_space_group_name_Hall           'C -2yc'
_space_group_name_H-M_alt        'C 1 c 1'
_symmetry_space_group_name_Hall  'C -2yc'
_symmetry_space_group_name_H-M   'C 1 c 1'
_atom_sites_solution_hydrogens   geom
_audit_creation_method           SHELXL-2014/7
_audit_update_record
;
2018-06-04 deposited with the CCDC.
2018-08-15 downloaded from the CCDC.
;
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_cell_angle_gamma                90
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_cell_measurement_temperature    297(2)
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_cell_measurement_theta_min      2.59
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_computing_cell_refinement       'Bruker SAINT'
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_diffrn_ambient_temperature      297(2)
_diffrn_measured_fraction_theta_full 1.000
_diffrn_measured_fraction_theta_max 0.995
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
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_diffrn_radiation_type           MoK\a
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_refine_ls_abs_structure_details
; 
 Flack x determined using 2432 quotients [(I+)-(I-)]/[(I+)+(I-)] 
 (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259). 
;
_refine_ls_abs_structure_Flack   0.05(4)
_refine_ls_extinction_method     none
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_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0745P)^2^+0.4972P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
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_reflns_Friedel_fraction_max     0.758
_reflns_number_gt                6592
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_reflns_threshold_expression     'I > 2\s(I)'
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_cod_data_source_block           T
_cod_depositor_comments          'Adding full bibliography for 7156375.cif.'
_cod_original_cell_volume        4628.8(18)
_cod_database_code               7156375
_shelx_shelxl_version_number     2014/7
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_shelx_estimated_absorpt_t_max   0.982
_shelx_res_checksum              84638