Organocatalytic Asymmetric Sequential 1,6-Addition/Acetalization of 1-Oxotetralin-2-carbaldehyde to ortho-Hydroxyphenyl-Substituted para-Quinone Methides for Synthesis of Spiro-3,4-dihydrocoumarins.
Zhang, Zhi-Pei; Chen, Li; Li, Xin; Cheng, Jin-Pei; The Journal of organic chemistry 83 (2018) 2714–2724; doi:10.1021/acs.joc.7b03177

data_4034970
_publ_section_title
;
 Organocatalytic Asymmetric Sequential 1,6-Addition/Acetalization of
 1-Oxotetralin-2-carbaldehyde to ortho-Hydroxyphenyl-Substituted
 para-Quinone Methides for Synthesis of Spiro-3,4-dihydrocoumarins.
;
_journal_issue                   5
_journal_name_full               'The Journal of organic chemistry'
_journal_page_first              2714
_journal_page_last               2724
_journal_paper_doi               10.1021/acs.joc.7b03177
_journal_volume                  83
_journal_year                    2018
_chemical_absolute_configuration ad
_chemical_formula_moiety         'C28 H34 O4'
_chemical_formula_sum            'C28 H34 O4'
_chemical_formula_weight         434.55
_space_group_crystal_system      monoclinic
_space_group_IT_number           4
_space_group_name_Hall           'P 2yb'
_space_group_name_H-M_alt        'P 1 21 1'
_atom_sites_solution_hydrogens   mixed
_atom_sites_solution_primary     dual
_audit_creation_date             2017-09-22
_audit_creation_method
;
Olex2 1.2
(compiled 2017.03.28 svn.r3405 for OlexSys, GUI svn.r5337)
;
_cell_angle_alpha                90
_cell_angle_beta                 103.3070(10)
_cell_angle_gamma                90
_cell_formula_units_Z            4
_cell_length_a                   10.06850(10)
_cell_length_b                   20.88460(10)
_cell_length_c                   12.21800(10)
_cell_measurement_reflns_used    33706
_cell_measurement_temperature    294.15
_cell_measurement_theta_max      78.8490
_cell_measurement_theta_min      4.2240
_cell_volume                     2500.18(4)
_computing_cell_refinement       'CrysAlisPro 1.171.39.3a (Rigaku OD, 2015)'
_computing_data_collection       'CrysAlisPro 1.171.39.3a (Rigaku OD, 2015)'
_computing_data_reduction        'CrysAlisPro 1.171.39.3a (Rigaku OD, 2015)'
_computing_molecular_graphics    'Olex2 (Dolomanov et al., 2009)'
_computing_publication_material  'Olex2 (Dolomanov et al., 2009)'
_computing_structure_refinement  'ShelXL (Sheldrick, 2015)'
_computing_structure_solution    'ShelXT (Sheldrick, 2015)'
_diffrn_ambient_temperature      294.15
_diffrn_detector                 PILT
_diffrn_measured_fraction_theta_full 1.000
_diffrn_measured_fraction_theta_max 0.992
_diffrn_measurement_details
;
List of Runs (angles in degrees, time in seconds):

  # Type    Start    End  Width  t~exp~   \w     \q     \k     \f   Frames
--------------------------------------------------------------------------
  1  \w   -125.00 -31.00   1.00    5.00    --  -35.00 -72.00-144.00   94
  2  \w    -35.00  55.00   1.00    5.00    --  -35.00  72.00 -72.00   90
  3  \w   -114.00 -21.00   1.00    5.00    --  -35.00 -72.00 -72.00   93
  4  \w    -50.00  40.00   1.00    5.00    --  -35.00  43.00-108.00   90
  5  \w   -125.00 -33.00   1.00    5.00    --  -35.00 -44.00 -36.00   92
  6  \w   -123.00 -33.00   1.00    5.00    --  -35.00 -72.00 144.00   90
  7  \w   -123.00 -33.00   1.00    5.00    --  -35.00 -72.00-108.00   90
  8  \w   -200.00-105.00   1.00   20.00    -- -110.00 -44.00-180.00   95
  9  \w   -125.00 -31.00   1.00   20.00    -- -110.00  72.00 108.00   94
 10  \w   -114.00 -20.00   1.00   20.00    -- -110.00  72.00-108.00   94
 11  \w   -200.00-110.00   1.00   20.00    -- -110.00 -44.00 108.00   90
 12  \w   -200.00-110.00   1.00   20.00    -- -110.00 -72.00   0.00   90
 13  \w   -124.00 -33.00   1.00   20.00    -- -110.00  72.00   0.00   91
 14  \w   -187.00 -96.00   1.00   20.00    -- -110.00 -15.00  36.00   91
 15  \w   -125.00 -31.00   1.00   20.00    -- -110.00  72.00-180.00   94
 16  \w   -122.00 -29.00   1.00   20.00    -- -110.00  72.00  72.00   93
 17  \w   -124.00 -34.00   1.00   20.00    -- -110.00  14.00  36.00   90
 18  \w   -114.00 -22.00   1.00   20.00    -- -110.00  14.00 -72.00   92
 19  \w   -115.00 -25.00   1.00   20.00    -- -110.00  72.00 -72.00   90
 20  \w   -191.00 -98.00   1.00   20.00    -- -110.00 -44.00-108.00   93
 21  \w   -122.00 -32.00   1.00   20.00    -- -110.00  72.00-144.00   90
 22  \w   -125.00 -33.00   1.00   20.00    -- -110.00  72.00  36.00   92
 23  \w   -200.00-110.00   1.00   20.00    -- -110.00 -15.00   0.00   90
 24  \w   -187.00 -96.00   1.00   20.00    -- -110.00 -72.00 -72.00   91
 25  \w   -123.00 -33.00   1.00   20.00    -- -110.00  72.00 -36.00   90
 26  \w   -125.00 -33.00   1.00   20.00    -- -110.00  43.00   0.00   92
 27  \w   -115.00 -25.00   1.00   20.00    -- -110.00  72.00 144.00   90
 28  \w   -195.00-105.00   1.00   20.00    -- -110.00 -72.00  72.00   90
;
_diffrn_measurement_device       'abstract diffractometer'
_diffrn_measurement_device_type  'Rigaku Xtalab P200'
_diffrn_measurement_method       '\w scans'
_diffrn_orient_matrix_type
'CrysAlisPro convention (1999,Acta A55,543-557)'
_diffrn_orient_matrix_UB_11      -0.1517332000
_diffrn_orient_matrix_UB_12      -0.0050271000
_diffrn_orient_matrix_UB_13      -0.0606749000
_diffrn_orient_matrix_UB_21      0.0224852000
_diffrn_orient_matrix_UB_22      -0.0697739000
_diffrn_orient_matrix_UB_23      -0.0324248000
_diffrn_orient_matrix_UB_31      -0.0345137000
_diffrn_orient_matrix_UB_32      -0.0233853000
_diffrn_orient_matrix_UB_33      0.1098087000
_diffrn_radiation_monochromator  confocal
_diffrn_radiation_probe          x-ray
_diffrn_radiation_type           CuK\a
_diffrn_radiation_wavelength     1.54184
_diffrn_reflns_av_R_equivalents  0.0146
_diffrn_reflns_av_unetI/netI     0.0099
_diffrn_reflns_Laue_measured_fraction_full 1.000
_diffrn_reflns_Laue_measured_fraction_max 0.992
_diffrn_reflns_limit_h_max       12
_diffrn_reflns_limit_h_min       -12
_diffrn_reflns_limit_k_max       26
_diffrn_reflns_limit_k_min       -26
_diffrn_reflns_limit_l_max       15
_diffrn_reflns_limit_l_min       -12
_diffrn_reflns_number            43572
_diffrn_reflns_point_group_measured_fraction_full 0.985
_diffrn_reflns_point_group_measured_fraction_max 0.962
_diffrn_reflns_theta_full        67.684
_diffrn_reflns_theta_max         79.158
_diffrn_reflns_theta_min         3.718
_diffrn_source                   'rotating anode'
_diffrn_source_type              'Enhance (Cu) X-ray Source'
_exptl_absorpt_coefficient_mu    0.601
_exptl_absorpt_correction_T_max  1.00000
_exptl_absorpt_correction_T_min  0.82614
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details
;
CrysAlisPro 1.171.39.3a (Rigaku Oxford Diffraction, 2015)
Empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_density_diffrn    1.154
_exptl_crystal_F_000             936
_exptl_crystal_size_max          0.28
_exptl_crystal_size_mid          0.24
_exptl_crystal_size_min          0.18
_refine_diff_density_max         0.173
_refine_diff_density_min         -0.183
_refine_diff_density_rms         0.026
_refine_ls_abs_structure_details
;
 Flack x determined using 4698 quotients [(I+)-(I-)]/[(I+)+(I-)]
 (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
;
_refine_ls_abs_structure_Flack   0.03(2)
_refine_ls_extinction_coef       0.0043(4)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc^2^\l^3^/sin(2\q)]^-1/4^
_refine_ls_extinction_method     'SHELXL-2014/7 (Sheldrick 2014'
_refine_ls_goodness_of_fit_ref   1.075
_refine_ls_hydrogen_treatment    mixed
_refine_ls_matrix_type           full
_refine_ls_number_parameters     598
_refine_ls_number_reflns         10416
_refine_ls_number_restraints     1
_refine_ls_restrained_S_all      1.075
_refine_ls_R_factor_all          0.0353
_refine_ls_R_factor_gt           0.0349
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0670P)^2^+0.1610P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1055
_refine_ls_wR_factor_ref         0.1060
_reflns_Friedel_coverage         0.886
_reflns_Friedel_fraction_full    0.968
_reflns_Friedel_fraction_max     0.930
_reflns_number_gt                10206
_reflns_number_total             10416
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            jo7b03177_si_004.cif
_cod_data_source_block           p20170921b
_cod_database_code               4034970
_shelx_shelxl_version_number     2014/7
_shelx_estimated_absorpt_t_max   0.900
_shelx_estimated_absorpt_t_min   0.850
_reflns_odcompleteness_completeness 99.19
_reflns_odcompleteness_iscentric 1
_reflns_odcompleteness_theta     78.91
_olex2_refinement_description
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H) groups, All C(H,H) groups
 At 1.5 times of:
  All C(H,H,H) groups
2.a Ternary CH refined with riding coordinates:
 C3(H3), C31(H31)
2.b Secondary CH2 refined with riding coordinates:
 C11(H11A,H11B), C12(H12A,H12B), C13(H13A,H13B), C14(H14A,H14B), C39(H39A,
 H39B), C40(H40A,H40B), C41(H41A,H41B), C42(H42A,H42B)
2.c Aromatic/amide H refined with riding coordinates:
 C6(H6), C7(H7), C8(H8), C9(H9), C16(H16), C20(H20), C33(H33), C34(H34),
 C35(H35), C36(H36), C44(H44), C48(H48)
2.d Idealised Me refined as rotating group:
 C22(H22A,H22B,H22C), C23(H23A,H23B,H23C), C24(H24A,H24B,H24C), C26(H26A,H26B,
 H26C), C27(H27A,H27B,H27C), C28(H28A,H28B,H28C), C50(H50A,H50B,H50C), C51(H51A,
 H51B,H51C), C52(H52A,H52B,H52C), C54(H54A,H54B,H54C), C55(H55A,H55B,H55C),
 C56(H56A,H56B,H56C)
;
_shelx_res_checksum              45879
_shelx_hkl_checksum              20150
_olex2_submission_special_instructions 'No special instructions were received'
_oxdiff_exptl_absorpt_empirical_details
;
Empirical correction (ABSPACK) includes:
- Absorption correction using spherical harmonics
- Frame scaling
- Detector area scaling
;
_oxdiff_exptl_absorpt_empirical_full_max 1.254
_oxdiff_exptl_absorpt_empirical_full_min 0.822