A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons
Yu-Man Ho; Ngan-Pan Bennett Au; Ka-Leung Wong; Chris Tsz-Leung Chan; Wai-Ming Kwok; Ga-Lai Law; Kwong-Kit Tang; Wai-Yeung Wong; Chi-Him Eddie Ma; Michael Hon-Wah Lam; Chem.Commun. 50 (2014) 4161–; doi:10.1039/C3CC48934E

data_7112217
_publ_section_title
;
 A lysosome-specific two-photon phosphorescent binuclear cyclometalated
 platinum(II) probe for in vivo imaging of live neurons
;
_journal_name_full               Chem.Commun.
_journal_page_first              4161
_journal_paper_doi               10.1039/C3CC48934E
_journal_volume                  50
_journal_year                    2014
_chemical_formula_sum            'C55 H50 Cl2 N6 O10 P2 Pt2'
_chemical_formula_weight         1478.03
_chemical_name_systematic
; 
 ? 
;
_space_group_IT_number           15
_symmetry_space_group_name_Hall  '-C 2yc'
_symmetry_space_group_name_H-M   'C 1 2/c 1'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_audit_creation_method           SHELXL-97
_cell_angle_alpha                90.00
_cell_angle_beta                 92.868(4)
_cell_angle_gamma                90.00
_cell_formula_units_Z            8
_cell_length_a                   21.4316(10)
_cell_length_b                   18.6779(8)
_cell_length_c                   28.2587(11)
_cell_measurement_temperature    133(2)
_cell_volume                     11297.7(8)
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_diffrn_ambient_temperature      133(2)
_diffrn_measured_fraction_theta_full 0.996
_diffrn_measured_fraction_theta_max 0.996
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           CuK\a
_diffrn_radiation_wavelength     1.54178
_diffrn_reflns_av_R_equivalents  0.0237
_diffrn_reflns_av_sigmaI/netI    0.0270
_diffrn_reflns_limit_h_max       25
_diffrn_reflns_limit_h_min       -21
_diffrn_reflns_limit_k_max       22
_diffrn_reflns_limit_k_min       -22
_diffrn_reflns_limit_l_max       33
_diffrn_reflns_limit_l_min       -30
_diffrn_reflns_number            22322
_diffrn_reflns_theta_full        67.00
_diffrn_reflns_theta_max         67.00
_diffrn_reflns_theta_min         3.13
_exptl_absorpt_coefficient_mu    11.053
_exptl_crystal_density_diffrn    1.738
_exptl_crystal_density_method    'not measured'
_exptl_crystal_F_000             5776
_refine_diff_density_max         1.821
_refine_diff_density_min         -1.482
_refine_diff_density_rms         0.133
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.259
_refine_ls_hydrogen_treatment    mixed
_refine_ls_matrix_type           full
_refine_ls_number_parameters     959
_refine_ls_number_reflns         10015
_refine_ls_number_restraints     586
_refine_ls_restrained_S_all      1.247
_refine_ls_R_factor_all          0.0530
_refine_ls_R_factor_gt           0.0511
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[\s^2^(Fo^2^)+(0.0002P)^2^+234.1776P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1035
_refine_ls_wR_factor_ref         0.1043
_reflns_number_gt                9606
_reflns_number_total             10015
_reflns_threshold_expression     >2sigma(I)
_cod_data_source_file            c3cc48934e.txt
_cod_data_source_block           072811a_man
_cod_database_code               7112217