Palladium-catalyzed enantioselective decarboxylative [3+2] cycloaddition of 5‑vinyloxazolidine-2,4-diones with sterically encumbered ketoimines toward chiral polycyclic 1,4-imidazolidinones
Liao, Juan; Sun, Wei; Sun, Guo-Yin; Peng, Xue-Song; Yang, Lei; You, Yong; Wang, Zhen-Hua; Zhao, Jian-Qiang; Zhou, Ming-Qiang; Yuan, Wei-Cheng; Organic & Biomolecular Chemistry  (2025) –; doi:10.1039/D6OB00235H

data_7161089
_publ_section_title
;
 Palladium-catalyzed enantioselective decarboxylative [3 + 2]
 cycloaddition of 5-vinyloxazolidine-2,4-diones with sterically encumbered
 ketoimines toward chiral polycyclic 1,4-imidazolidinones.
;
_journal_issue                   15
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              3192
_journal_page_last               3197
_journal_paper_doi               10.1039/d6ob00235h
_journal_volume                  24
_journal_year                    2026
_chemical_absolute_configuration ad
_chemical_formula_moiety         'C27 H24 N2 O7 S'
_chemical_formula_sum            'C27 H24 N2 O7 S'
_chemical_formula_weight         520.54
_space_group_crystal_system      orthorhombic
_space_group_IT_number           19
_space_group_name_Hall           'P 2ac 2ab'
_space_group_name_H-M_alt        'P 21 21 21'
_atom_sites_solution_hydrogens   mixed
_atom_sites_solution_primary     direct
_audit_creation_date             2024-03-16
_audit_creation_method
;
Olex2 1.5-beta
(compiled 2022.04.07 svn.rca3783a0 for OlexSys, GUI svn.r6439)
;
_audit_update_record
;
2024-11-11 deposited with the CCDC.	2026-03-20 downloaded from the CCDC.
;
_cell_angle_alpha                90
_cell_angle_beta                 90
_cell_angle_gamma                90
_cell_formula_units_Z            4
_cell_length_a                   8.30340(10)
_cell_length_b                   11.10390(10)
_cell_length_c                   26.7028(3)
_cell_measurement_reflns_used    20060
_cell_measurement_temperature    293.15
_cell_measurement_theta_max      76.4480
_cell_measurement_theta_min      3.9600
_cell_volume                     2462.00(5)
_computing_cell_refinement       'CrysAlisPro 1.171.42.73a (Rigaku OD, 2022)'
_computing_data_collection       'CrysAlisPro 1.171.42.73a (Rigaku OD, 2022)'
_computing_data_reduction        'CrysAlisPro 1.171.42.73a (Rigaku OD, 2022)'
_computing_molecular_graphics    'Olex2 1.5-beta (Dolomanov et al., 2009)'
_computing_publication_material  'Olex2 1.5-beta (Dolomanov et al., 2009)'
_computing_structure_refinement  'SHELXL 2018/3 (Sheldrick, 2015)'
_computing_structure_solution    'SHELXS  (Sheldrick, 2008)'
_diffrn_ambient_temperature      293.15
_diffrn_detector                 'Hybrid Pixel Array Detector'
_diffrn_detector_area_resol_mean 10.0000
_diffrn_detector_type            HyPix
_diffrn_measured_fraction_theta_full 0.999
_diffrn_measured_fraction_theta_max 0.984
_diffrn_measurement_details
;
List of Runs (angles in degrees, time in seconds):

  # Type    Start    End  Width  t~exp~   \w     \q     \k     \f   Frames
  1  \w     91.00 177.00   0.50    0.30    --  104.75  57.00 150.00  172
  2  \w     94.00 119.00   0.50    0.30    --  104.75  38.00 -90.00   50
  3  \w    -25.00  29.00   0.50    0.20    --   48.13 -19.00 -30.00  108
  4  \w    -25.00  29.00   0.50    0.20    --   48.13 -19.00  60.00  108
  5  \w     33.00  68.00   0.50    0.30    --  104.75 -57.00 120.00   70
  6  \w     18.00  93.00   0.50    0.20    --   48.13-125.00  30.00  150
  7  \w     36.00 111.00   0.50    0.30    --  104.75-125.00 -60.00  150
  8  \w     36.00 111.00   0.50    0.30    --  104.75-125.00   0.00  150
  9  \w     33.00 130.00   0.50    0.30    --  104.75 -85.00 -12.00  194
 10  \w   -119.00 -26.00   0.50    0.20    --  -48.13 -77.00 120.00  186
 11  \w   -119.00 -34.00   0.50    0.20    --  -48.13 -57.00  30.00  170
 12  \w   -119.00 -26.00   0.50    0.20    --  -48.13 -77.00 -30.00  186
 13  \w   -119.00 -37.00   0.50    0.20    --  -48.13 -45.00-170.00  164
 14  \w   -175.00 -93.00   0.50    0.30    -- -104.00 -45.00-170.00  164
 15  \w   -175.00 -90.00   0.50    0.30    -- -104.00 -57.00  60.00  170
 16  \w   -175.00 -90.00   0.50    0.30    -- -104.00 -57.00  90.00  170
 17  \w    -64.00 -32.00   0.50    0.30    -- -104.00  57.00 120.00   64
 18  \w    -64.00 -32.00   0.50    0.30    -- -104.00  57.00  60.00   64
 19  \w   -106.00 -34.00   0.50    0.30    -- -104.00 101.00-161.00  144
 20  \w    -41.00  24.00   0.50    0.20    --  -48.13  38.00-180.00  130
;
_diffrn_measurement_device       'four-circle diffractometer'
_diffrn_measurement_device_type  'XtaLAB Synergy R, DW system, HyPix'
_diffrn_measurement_method       '\w scans'
_diffrn_orient_matrix_type
'CrysAlisPro convention (1999,Acta A55,543-557)'
_diffrn_orient_matrix_UB_11      0.1113052000
_diffrn_orient_matrix_UB_12      -0.1107569000
_diffrn_orient_matrix_UB_13      0.0029694000
_diffrn_orient_matrix_UB_21      0.1196954000
_diffrn_orient_matrix_UB_22      0.0722319000
_diffrn_orient_matrix_UB_23      0.0322387000
_diffrn_orient_matrix_UB_31      -0.0878778000
_diffrn_orient_matrix_UB_32      -0.0419199000
_diffrn_orient_matrix_UB_33      0.0477502000
_diffrn_radiation_monochromator  mirror
_diffrn_radiation_probe          x-ray
_diffrn_radiation_type           'Cu K\a'
_diffrn_radiation_wavelength     1.54184
_diffrn_reflns_av_R_equivalents  0.0192
_diffrn_reflns_av_unetI/netI     0.0119
_diffrn_reflns_Laue_measured_fraction_full 0.999
_diffrn_reflns_Laue_measured_fraction_max 0.984
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_h_min       -10
_diffrn_reflns_limit_k_max       12
_diffrn_reflns_limit_k_min       -14
_diffrn_reflns_limit_l_max       33
_diffrn_reflns_limit_l_min       -31
_diffrn_reflns_number            23700
_diffrn_reflns_point_group_measured_fraction_full 0.999
_diffrn_reflns_point_group_measured_fraction_max 0.969
_diffrn_reflns_theta_full        67.684
_diffrn_reflns_theta_max         76.591
_diffrn_reflns_theta_min         3.310
_diffrn_source                   'Rotating-anode X-ray tube'
_diffrn_source_type              'Rigaku (Cu) X-ray Source'
_exptl_absorpt_coefficient_mu    1.606
_exptl_absorpt_correction_T_max  1.00000
_exptl_absorpt_correction_T_min  0.69701
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details
;
CrysAlisPro 1.171.42.73a (Rigaku Oxford Diffraction, 2022)
Empirical absorption correction using spherical harmonics,
implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            'light colourless'
_exptl_crystal_density_diffrn    1.404
_exptl_crystal_description       block
_exptl_crystal_F_000             1088
_exptl_crystal_size_max          0.15
_exptl_crystal_size_mid          0.12
_exptl_crystal_size_min          0.11
_refine_diff_density_max         0.337
_refine_diff_density_min         -0.205
_refine_diff_density_rms         0.032
_refine_ls_abs_structure_details
;
 Flack x determined using 2023 quotients [(I+)-(I-)]/[(I+)+(I-)]
 (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
;
_refine_ls_abs_structure_Flack   0.003(3)
_refine_ls_extinction_coef       0.0034(3)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc^2^\l^3^/sin(2\q)]^-1/4^
_refine_ls_extinction_method     'SHELXL-2018/3 (Sheldrick 2018)'
_refine_ls_goodness_of_fit_ref   1.043
_refine_ls_hydrogen_treatment    mixed
_refine_ls_matrix_type           full
_refine_ls_number_parameters     345
_refine_ls_number_reflns         5023
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.043
_refine_ls_R_factor_all          0.0292
_refine_ls_R_factor_gt           0.0288
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0524P)^2^+0.3206P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0826
_refine_ls_wR_factor_ref         0.0830
_reflns_Friedel_coverage         0.726
_reflns_Friedel_fraction_full    0.999
_reflns_Friedel_fraction_max     0.950
_reflns_number_gt                4923
_reflns_number_total             5023
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            d6ob00235h2.cif
_cod_data_source_block           20240314lj-1
_cod_depositor_comments
'Adding full bibliography for 7161089--7161090.cif.'
_cod_database_code               7161089
_shelx_shelxl_version_number     2018/3
_chemical_oxdiff_formula         'C H O N S'
_olex2_refinement_description
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H) groups, All C(H,H) groups
 At 1.5 times of:
  All C(H,H,H) groups
2.a Secondary CH2 refined with riding coordinates:
 C19(H19A,H19B)
2.b Aromatic/amide H refined with riding coordinates:
 C2(H2), C3(H3), C5(H5), C11(H11), C14(H14), C15(H15), C16(H16), C17(H17),
 C18(H18), C21(H21), C22(H22), C23(H23), C24(H24), C25(H25)
2.c Idealised Me refined as rotating group:
 C26(H26A,H26B,H26C), C27(H27A,H27B,H27C)
;
_shelx_res_checksum              37922
_olex2_submission_special_instructions 'No special instructions were received'
_oxdiff_exptl_absorpt_empirical_details
;
Empirical correction (ABSPACK) includes:
- Absorption correction using spherical harmonics
- Frame scaling
;
_oxdiff_exptl_absorpt_empirical_full_max 1.435
_oxdiff_exptl_absorpt_empirical_full_min 0.702