An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(i)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile.
Yu, Xingxin; Yang, Qin; Lou, Honglei; Peng, Yiyuan; Wu, Jie; Organic & biomolecular chemistry 9 (2011) 7033–7037; doi:10.1039/c1ob05917c

data_7152007
_publ_section_title
;
 An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a
 silver(i)-catalyzed three-component reaction of 2-alkynylbenzaldehyde,
 sulfonohydrazide, and nitrile.
;
_journal_issue                   20
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              7033
_journal_page_last               7037
_journal_paper_doi               10.1039/c1ob05917c
_journal_volume                  9
_journal_year                    2011
_chemical_formula_sum            'C16 H16 N4'
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_symmetry_space_group_name_Hall  '-P 1'
_symmetry_space_group_name_H-M   'P -1'
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_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
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_cell_angle_gamma                80.272(2)
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_cell_length_b                   9.930(2)
_cell_length_c                   14.630(3)
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_cell_measurement_theta_min      2.48
_cell_volume                     1375.8(5)
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 2008)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 2008)'
_diffrn_ambient_temperature      273(2)
_diffrn_measured_fraction_theta_full 0.979
_diffrn_measured_fraction_theta_max 0.979
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
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_diffrn_reflns_limit_h_max       5
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_diffrn_reflns_limit_k_min       -11
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_exptl_absorpt_correction_T_min  0.6000
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   SABABS
_exptl_crystal_colour            colorless
_exptl_crystal_density_diffrn    1.276
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       block
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_refine_diff_density_max         0.291
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_refine_diff_density_rms         0.087
_refine_ls_extinction_method     none
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_refine_ls_number_reflns         4851
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_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[\s^2^(Fo^2^)+(0.0842P)^2^+0.2073P] where P=(Fo^2^+2Fc^2^)/3'
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_refine_ls_wR_factor_gt          0.1335
_refine_ls_wR_factor_ref         0.1436
_reflns_number_gt                4099
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_reflns_threshold_expression     >2sigma(I)
_cod_data_source_file            c1ob05917c.txt
_cod_data_source_block           a10505c_0m
_cod_original_cell_volume        1375.9(5)
_cod_original_sg_symbol_H-M      P-1
_cod_database_code               7152007