Enantioselective synthesis of tetrahydrocyclopenta[b]indole bearing a chiral quaternary carbon center via Pd(II)-SPRIX-catalyzed C‒H activation
Abozeid, Mohamed A.; Sairenji, Shiho; Takizawa, Shinobu; Fujita, Makoto; Sasai, Hiroaki; Chem. Commun.  (2017) –; doi:10.1039/C7CC03199H

data_7120229
_publ_section_title
;
 Enantioselective synthesis of tetrahydrocyclopenta[b]indole bearing a
 chiral quaternary carbon center via Pd(II)-SPRIX-catalyzed C--H
 activation
;
_journal_name_full               'Chem. Commun.'
_journal_paper_doi               10.1039/C7CC03199H
_journal_year                    2017
_chemical_absolute_configuration S
_chemical_formula_moiety
'(C72 H48 N24 I12 Zn6), 3.41(C15 H17 N), 2.16(C6 H12)'
_chemical_formula_sum            'C136.11 H131.89 I12 N27.41 Zn6'
_chemical_formula_weight         4066.65
_space_group_crystal_system      monoclinic
_space_group_IT_number           5
_space_group_name_Hall           'C 2y'
_space_group_name_H-M_alt        'C 1 2 1'
_symmetry_space_group_name_Hall  'C 2y'
_symmetry_space_group_name_H-M   'C 1 2 1'
_atom_sites_solution_hydrogens   geom
_audit_block_doi                 10.5517/ccdc.csd.cc1m2q9q
_audit_creation_method           SHELXL-2016/6
_audit_update_record
;
2017-04-28 deposited with the CCDC.
2017-06-06 downloaded from the CCDC.
;
_cell_angle_alpha                90
_cell_angle_beta                 109.742(2)
_cell_angle_gamma                90
_cell_formula_units_Z            4
_cell_length_a                   36.1897(8)
_cell_length_b                   14.6874(2)
_cell_length_c                   34.7427(8)
_cell_measurement_reflns_used    28199
_cell_measurement_temperature    100(2)
_cell_measurement_theta_max      75.7310
_cell_measurement_theta_min      3.9540
_cell_volume                     17381.5(6)
_computing_cell_refinement       'CrysAlisPro 1.171.38.41 (Rigaku OD, 2015)'
_computing_data_collection       'CrysAlisPro 1.171.38.41 (Rigaku OD, 2015)'
_computing_data_reduction        'CrysAlisPro 1.171.38.41 (Rigaku OD, 2015)'
_computing_molecular_graphics    'shelXle (Hubschle et al., 2011)'
_computing_publication_material  'SHELXL-2014/7 (Sheldrick, 2014)'
_computing_structure_refinement  'SHELXL-2014/7 (Sheldrick, 2014)'
_computing_structure_solution    'SHELXT-2014/5 (Sheldrick, 2014)'
_diffrn_ambient_temperature      100(2)
_diffrn_detector_area_resol_mean 5.3040
_diffrn_measured_fraction_theta_full 1.000
_diffrn_measured_fraction_theta_max 0.993
_diffrn_measurement_device_type  'SuperNova, Dual, Cu at zero, AtlasS2'
_diffrn_measurement_method       '\w scans'
_diffrn_radiation_type           CuK\a
_diffrn_radiation_wavelength     1.54187
_diffrn_reflns_av_R_equivalents  0.0558
_diffrn_reflns_av_unetI/netI     0.0696
_diffrn_reflns_Laue_measured_fraction_full 1.000
_diffrn_reflns_Laue_measured_fraction_max 0.993
_diffrn_reflns_limit_h_max       45
_diffrn_reflns_limit_h_min       -44
_diffrn_reflns_limit_k_max       18
_diffrn_reflns_limit_k_min       -18
_diffrn_reflns_limit_l_max       42
_diffrn_reflns_limit_l_min       -43
_diffrn_reflns_number            87712
_diffrn_reflns_point_group_measured_fraction_full 0.998
_diffrn_reflns_point_group_measured_fraction_max 0.982
_diffrn_reflns_theta_full        67.687
_diffrn_reflns_theta_max         76.010
_diffrn_reflns_theta_min         3.709
_diffrn_source                   'micro-focus sealed X-ray tube'
_exptl_absorpt_coefficient_mu    18.024
_exptl_absorpt_correction_T_max  0.327
_exptl_absorpt_correction_T_min  0.035
_exptl_absorpt_correction_type   gaussian
_exptl_absorpt_process_details
;
CrysAlisPro 1.171.38.41 (Rigaku Oxford Diffraction, 2015)
Numerical absorption correction based on gaussian integration over
            a multifaceted crystal model
Empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            red
_exptl_crystal_density_diffrn    1.554
_exptl_crystal_description       block
_exptl_crystal_F_000             7826
_exptl_crystal_size_max          0.386
_exptl_crystal_size_mid          0.200
_exptl_crystal_size_min          0.097
_refine_diff_density_max         1.512
_refine_diff_density_min         -0.997
_refine_diff_density_rms         0.161
_refine_ls_abs_structure_details
;
 Flack x determined using 10616 quotients [(I+)-(I-)]/[(I+)+(I-)]
 (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
;
_refine_ls_abs_structure_Flack   0.056(11)
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.047
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     2518
_refine_ls_number_reflns         35687
_refine_ls_number_restraints     2179
_refine_ls_restrained_S_all      1.027
_refine_ls_R_factor_all          0.0865
_refine_ls_R_factor_gt           0.0742
_refine_ls_shift/su_max          0.030
_refine_ls_shift/su_mean         0.001
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.1247P)^2^+51.8756P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.2049
_refine_ls_wR_factor_ref         0.2219
_reflns_Friedel_coverage         0.903
_reflns_Friedel_fraction_full    0.997
_reflns_Friedel_fraction_max     0.971
_reflns_number_gt                29054
_reflns_number_total             35687
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            c7cc03199h2.cif
_cod_data_source_block           SHELXT_c
_cod_database_code               7120229
_shelx_shelxl_version_number     2016/6
_shelx_res_checksum              69880