One-pot synthesis of benzofused 8-oxabicyclo[3.3.1]nonanes <i>via</i> GaCl<sub>3</sub>-mediated cyclocondensation of <i>o</i>-allylbenzaldehydes and 1,3-dicarbonyl synthons.
Chang, Meng-Yang; Lee, Yan-Ling; Organic & biomolecular chemistry 22 (2024) 1646–1653; doi:10.1039/d4ob00016a

data_7159780
_publ_section_title
;
 One-pot synthesis of benzofused 8-oxabicyclo[3.3.1]nonanes <i>via</i>
 GaCl<sub>3</sub>-mediated cyclocondensation of
 <i>o</i>-allylbenzaldehydes and 1,3-dicarbonyl synthons.
;
_journal_issue                   8
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              1646
_journal_page_last               1653
_journal_paper_doi               10.1039/d4ob00016a
_journal_volume                  22
_journal_year                    2024
_chemical_formula_moiety         'C18 H20 O4'
_chemical_formula_sum            'C18 H20 N O3'
_chemical_formula_weight         298.35
_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_Hall           '-P 2yn'
_space_group_name_H-M_alt        'P 1 21/n 1'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     dual
_audit_creation_date             2023-11-06
_audit_creation_method
;
Olex2 1.5
(compiled 2023.08.24 svn.re1ec1418 for OlexSys, GUI svn.r6817)
;
_audit_update_record
;
2023-11-23 deposited with the CCDC.	2024-01-29 downloaded from the CCDC.
;
_cell_angle_alpha                90
_cell_angle_beta                 95.207(5)
_cell_angle_gamma                90
_cell_formula_units_Z            4
_cell_length_a                   7.7589(4)
_cell_length_b                   10.0726(7)
_cell_length_c                   18.9645(10)
_cell_measurement_reflns_used    10610
_cell_measurement_temperature    130(2)
_cell_measurement_theta_max      26.8830
_cell_measurement_theta_min      2.1530
_cell_volume                     1476.00(15)
_computing_cell_refinement       'CrysAlisPro 1.171.41.123a (Rigaku OD, 2022)'
_computing_data_collection       'CrysAlisPro 1.171.41.123a (Rigaku OD, 2022)'
_computing_data_reduction        'CrysAlisPro 1.171.41.123a (Rigaku OD, 2022)'
_computing_molecular_graphics    'Olex2 1.5 (Dolomanov et al., 2009)'
_computing_publication_material  'Olex2 1.5 (Dolomanov et al., 2009)'
_computing_structure_refinement  'SHELXL 2018/3 (Sheldrick, 2015)'
_computing_structure_solution    'SHELXT 2018/2 (Sheldrick, 2018)'
_diffrn_ambient_temperature      130(2)
_diffrn_detector                 'Hybrid Pixel Array Detector'
_diffrn_detector_area_resol_mean 10.0000
_diffrn_measured_fraction_theta_full 0.994
_diffrn_measured_fraction_theta_max 0.951
_diffrn_measurement_details
;
List of Runs (angles in degrees, time in seconds):

  # Type    Start    End  Width  t~exp~   \w     \q     \k     \f   Frames
  1  \w    -79.00  43.00   0.50    5.95    --   10.60 -53.00  91.00  244
  2  \w    -22.00 100.00   0.50    5.95    --   10.60  53.00-123.00  244
  3  \w   -100.00  21.00   0.50    5.95    --  -10.90 -53.00  91.00  242
  4  \w    -43.00  78.00   0.50    5.95    --  -10.90  53.00-123.00  242
  5  \w     13.00  50.00   0.50    5.95    --   10.60  77.00 -90.00   74
  6  \w    -77.00  43.00   0.50    5.95    --   10.60 -37.00-180.00  240
  7  \w    -15.00  89.00   0.50    5.95    --   10.60  77.00  60.00  208
  8  \w    -13.00 100.00   0.50    5.95    --   10.60  82.00 -60.00  226
  9  \w    -54.00 -28.00   0.50    5.95    --   10.60 -77.00  30.00   52
 10  \w     11.00  36.00   0.50    5.95    --   10.60 -77.00  30.00   50
 11  \w    -38.00   2.00   0.50    5.95    --  -10.90 -37.00 -60.00   80
 12  \w    -95.00 -69.00   0.50    5.95    --  -10.90 -37.00 -60.00   52
;
_diffrn_measurement_device       'four-circle diffractometer'
_diffrn_measurement_device_type  'XtaLAB Pro II AFC12 (RINC): Kappa single'
_diffrn_measurement_method       '\w scans'
_diffrn_orient_matrix_type
'CrysAlisPro convention (1999,Acta A55,543-557)'
_diffrn_orient_matrix_UB_11      -0.0598932000
_diffrn_orient_matrix_UB_12      0.0433681000
_diffrn_orient_matrix_UB_13      0.0143317000
_diffrn_orient_matrix_UB_21      0.0393121000
_diffrn_orient_matrix_UB_22      -0.0125580000
_diffrn_orient_matrix_UB_23      0.0345608000
_diffrn_orient_matrix_UB_31      0.0573240000
_diffrn_orient_matrix_UB_32      0.0540285000
_diffrn_orient_matrix_UB_33      -0.0034281000
_diffrn_radiation_monochromator  mirror
_diffrn_radiation_probe          x-ray
_diffrn_radiation_type           'Mo K\a'
_diffrn_radiation_wavelength     0.71073
_diffrn_reflns_av_R_equivalents  0.0789
_diffrn_reflns_av_unetI/netI     0.0539
_diffrn_reflns_Laue_measured_fraction_full 0.994
_diffrn_reflns_Laue_measured_fraction_max 0.951
_diffrn_reflns_limit_h_max       9
_diffrn_reflns_limit_h_min       -9
_diffrn_reflns_limit_k_max       12
_diffrn_reflns_limit_k_min       -12
_diffrn_reflns_limit_l_max       23
_diffrn_reflns_limit_l_min       -24
_diffrn_reflns_number            23702
_diffrn_reflns_point_group_measured_fraction_full 0.994
_diffrn_reflns_point_group_measured_fraction_max 0.951
_diffrn_reflns_theta_full        25.242
_diffrn_reflns_theta_max         27.067
_diffrn_reflns_theta_min         2.157
_diffrn_source                   'micro-focus sealed X-ray tube'
_diffrn_source_type              'Rigaku (Mo) X-ray Source'
_exptl_absorpt_coefficient_mu    0.091
_exptl_absorpt_correction_T_max  1.00000
_exptl_absorpt_correction_T_min  0.27884
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details
;
CrysAlisPro 1.171.41.123a (Rigaku Oxford Diffraction, 2022)
Empirical absorption correction using spherical harmonics,
implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            yellow
_exptl_crystal_colour_primary    yellow
_exptl_crystal_density_diffrn    1.343
_exptl_crystal_description       block
_exptl_crystal_F_000             636
_exptl_crystal_size_max          0.5
_exptl_crystal_size_mid          0.5
_exptl_crystal_size_min          0.5
_refine_diff_density_max         0.425
_refine_diff_density_min         -0.283
_refine_diff_density_rms         0.078
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.078
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     201
_refine_ls_number_reflns         3082
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.078
_refine_ls_R_factor_all          0.0845
_refine_ls_R_factor_gt           0.0718
_refine_ls_shift/su_max          0.025
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0710P)^2^+2.5804P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1837
_refine_ls_wR_factor_ref         0.1897
_reflns_Friedel_coverage         0.000
_reflns_number_gt                2519
_reflns_number_total             3082
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            d4ob00016a2.cif
_cod_data_source_block           k11211-myc-a(ynb928)_auto
_cod_depositor_comments
'Adding full bibliography for 7159780--7159782.cif.'
_cod_database_code               7159780
_shelx_shelxl_version_number     2018/3
_shelx_estimated_absorpt_t_max   0.956
_shelx_estimated_absorpt_t_min   0.956
_olex2_refinement_description
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H) groups, All C(H,H) groups
 At 1.5 times of:
  All C(H,H,H) groups
2.a Ternary CH refined with riding coordinates:
 C7(H00B), C17(H00F)
2.b Secondary CH2 refined with riding coordinates:
 C18(H00A,H00D), C2(H00E,H00G), C3(H00H,H00I), C16(H00J,H00K), C4(H00R,H00S)
2.c Aromatic/amide H refined with riding coordinates:
 C9(H006), C10(H00C)
2.d Idealised Me refined as rotating group:
 C12(H00L,H00M,H00N), C14(H00O,H00P,H00Q)
;
_shelx_res_checksum              62748
_olex2_submission_special_instructions 'No special instructions were received'
_oxdiff_exptl_absorpt_empirical_details
;
Empirical correction (ABSPACK) includes:
- Absorption correction using spherical harmonics
- Frame scaling
;
_oxdiff_exptl_absorpt_empirical_full_max 2.439
_oxdiff_exptl_absorpt_empirical_full_min 0.411