Highly Enantioselective Nickel-Catalyzed Intramolecular Hydroalkenylation of N- and O-Tethered 1,6-Dienes To Form Six-Membered Heterocycles.
Li, Ke; Li, Mao-Lin; Zhang, Qi; Zhu, Shou-Fei; Zhou, Qi-Lin; Journal of the American Chemical Society 140 (2018) 7458–7461; doi:10.1021/jacs.8b04703

data_4132535
_publ_section_title
;
 Highly Enantioselective Nickel-Catalyzed Intramolecular Hydroalkenylation
 of N- and O-Tethered 1,6-Dienes To Form Six-Membered Heterocycles.
;
_journal_issue                   24
_journal_name_full               'Journal of the American Chemical Society'
_journal_page_first              7458
_journal_page_last               7461
_journal_paper_doi               10.1021/jacs.8b04703
_journal_volume                  140
_journal_year                    2018
_chemical_absolute_configuration ad
_chemical_formula_moiety         'C13 H14 O3'
_chemical_formula_sum            'C13 H14 O3'
_chemical_formula_weight         218.24
_space_group_crystal_system      monoclinic
_space_group_IT_number           4
_space_group_name_Hall           'P 2yb'
_space_group_name_H-M_alt        'P 1 21 1'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_audit_creation_date             2016-05-18
_audit_creation_method
;
Olex2 1.2-ac21
(compiled 2015.09.16 svn.r134, GUI svn.r4998)
;
_cell_angle_alpha                90
_cell_angle_beta                 92.8518(7)
_cell_angle_gamma                90
_cell_formula_units_Z            6
_cell_length_a                   5.88468(5)
_cell_length_b                   24.0880(2)
_cell_length_c                   11.56387(9)
_cell_measurement_reflns_used    23190
_cell_measurement_temperature    173.15
_cell_measurement_theta_max      78.8780
_cell_measurement_theta_min      3.6620
_cell_volume                     1637.15(2)
_computing_cell_refinement
;
CrysAlisPro 1.171.38.41 (Rigaku OD, 2015)
;
_computing_data_collection
;
CrystalClear-SM Expert 2.1 b42 (Rigaku, 2015)
;
_computing_data_reduction
;
CrysAlisPro 1.171.38.41 (Rigaku OD, 2015)
;
_computing_molecular_graphics    'Olex2 (Dolomanov et al., 2009)'
_computing_publication_material  'Olex2 (Dolomanov et al., 2009)'
_computing_structure_refinement  'ShelXL (Sheldrick, 2008)'
_computing_structure_solution    'ShelXT (Sheldrick, 2015)'
_diffrn_ambient_temperature      173.15
_diffrn_detector                 PILT
_diffrn_detector_area_resol_mean 5.814
_diffrn_detector_type            'Rigaku Pilatus 200K'
_diffrn_measured_fraction_theta_full 1.000
_diffrn_measured_fraction_theta_max 0.991
_diffrn_measurement_details
;
List of Runs (angles in degrees, time in seconds):

  # Type    Start    End  Width  t~exp~   \w     \q     \k     \f   Frames
--------------------------------------------------------------------------
  1  \w   -125.00 -31.00   1.00    5.00    --  -35.00 -72.00 -72.00   94
  2  \w   -125.00 -32.00   1.00    5.00    --  -35.00 -72.00   0.00   93
  3  \w    -50.00  40.00   1.00    5.00    --  -35.00  43.00   0.00   90
  4  \w    -50.00  40.00   1.00    5.00    --  -35.00  72.00 108.00   90
  5  \w   -115.00 -25.00   1.00    5.00    --  -35.00 -72.00 -36.00   90
  6  \w    -50.00  40.00   1.00    5.00    --  -35.00  72.00  36.00   90
  7  \w   -119.00 -29.00   1.00    5.00    --  -35.00 -15.00  72.00   90
  8  \w   -115.00 -25.00   1.00    5.00    --  -35.00 -72.00-144.00   90
  9  \w   -115.00 -25.00   1.00    5.00    --  -35.00 -44.00 -36.00   90
 10  \w   -200.00 -96.00   1.00    5.00    -- -110.00 -44.00-180.00  104
 11  \w   -200.00 -96.00   1.00    5.00    -- -110.00 -44.00 -36.00  104
 12  \w   -187.00 -96.00   1.00    5.00    -- -110.00 -72.00-108.00   91
 13  \w   -200.00-110.00   1.00    5.00    -- -110.00 -72.00 144.00   90
 14  \w   -187.00 -96.00   1.00    5.00    -- -110.00 -44.00 -72.00   91
 15  \w   -187.00 -96.00   1.00    5.00    -- -110.00 -44.00   0.00   91
 16  \w   -125.00 -32.00   1.00    5.00    -- -110.00  72.00  36.00   93
 17  \w   -187.00 -96.00   1.00    5.00    -- -110.00 -44.00-108.00   91
 18  \w   -125.00 -33.00   1.00    5.00    -- -110.00  14.00 -36.00   92
 19  \w   -115.00 -22.00   1.00    5.00    -- -110.00  72.00-108.00   93
 20  \w   -194.00 -96.00   1.00    5.00    -- -110.00 -72.00   0.00   98
 21  \w   -187.00 -96.00   1.00    5.00    -- -110.00 -72.00 -36.00   91
 22  \w   -187.00 -96.00   1.00    5.00    -- -110.00 -72.00 -72.00   91
 23  \w   -125.00 -33.00   1.00    5.00    -- -110.00  43.00  36.00   92
 24  \w   -200.00-110.00   1.00    5.00    -- -110.00 -15.00-144.00   90
 25  \w   -200.00-110.00   1.00    5.00    -- -110.00 -15.00 -72.00   90
 26  \w   -115.00 -25.00   1.00    5.00    -- -110.00  72.00 -72.00   90
 27  \w   -200.00-110.00   1.00    5.00    -- -110.00 -15.00-108.00   90
 28  \w   -187.00 -97.00   1.00    5.00    -- -110.00 -15.00 -36.00   90
;
_diffrn_measurement_device       'AFC12 (Right): Kappa 3 circle'
_diffrn_measurement_device_type  'Rigaku XtaLab P200'
_diffrn_measurement_method       'profile data from \w-scans'
_diffrn_measurement_specimen_support Fiber
_diffrn_orient_matrix_type
'CrysAlisPro convention (1999,Acta A55,543-557)'
_diffrn_orient_matrix_UB_11      0.2546882000
_diffrn_orient_matrix_UB_12      0.0112426000
_diffrn_orient_matrix_UB_13      0.0279271000
_diffrn_orient_matrix_UB_21      0.0577138000
_diffrn_orient_matrix_UB_22      -0.0257811000
_diffrn_orient_matrix_UB_23      -0.1169021000
_diffrn_orient_matrix_UB_31      -0.0241433000
_diffrn_orient_matrix_UB_32      0.0574086000
_diffrn_orient_matrix_UB_33      -0.0578245000
_diffrn_radiation_collimation    0.3
_diffrn_radiation_monochromator  Confocal
_diffrn_radiation_probe          x-ray
_diffrn_radiation_type           CuK\a
_diffrn_radiation_wavelength     1.54184
_diffrn_reflns_av_R_equivalents  0.0160
_diffrn_reflns_av_unetI/netI     0.0117
_diffrn_reflns_Laue_measured_fraction_full 1.000
_diffrn_reflns_Laue_measured_fraction_max 0.991
_diffrn_reflns_limit_h_max       7
_diffrn_reflns_limit_h_min       -7
_diffrn_reflns_limit_k_max       30
_diffrn_reflns_limit_k_min       -27
_diffrn_reflns_limit_l_max       13
_diffrn_reflns_limit_l_min       -14
_diffrn_reflns_number            27007
_diffrn_reflns_point_group_measured_fraction_full 0.943
_diffrn_reflns_point_group_measured_fraction_max 0.920
_diffrn_reflns_theta_full        67.684
_diffrn_reflns_theta_max         79.112
_diffrn_reflns_theta_min         3.670
_diffrn_source                   'Rotating Anode'
_diffrn_source_current           30.0
_diffrn_source_power             1.2
_diffrn_source_target            Cu
_diffrn_source_type              'Rotating Anode'
_diffrn_source_voltage           40.0
_exptl_absorpt_coefficient_mu    0.766
_exptl_absorpt_correction_T_max  1.00000
_exptl_absorpt_correction_T_min  0.85295
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details
;
CrysAlisPro 1.171.38.41 (Rigaku Oxford Diffraction, 2015)
Empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            colourless
_exptl_crystal_colour_primary    colourless
_exptl_crystal_density_diffrn    1.328
_exptl_crystal_description       prism
_exptl_crystal_F_000             696
_exptl_crystal_size_max          0.240
_exptl_crystal_size_mid          0.22
_exptl_crystal_size_min          0.18
_refine_diff_density_max         0.131
_refine_diff_density_min         -0.106
_refine_diff_density_rms         0.028
_refine_ls_abs_structure_details
;
 Flack x determined using 2844 quotients [(I+)-(I-)]/[(I+)+(I-)]
 (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
;
_refine_ls_abs_structure_Flack   0.02(4)
_refine_ls_extinction_coef       0.0086(5)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc^2^\l^3^/sin(2\q)]^-1/4^
_refine_ls_extinction_method     'SHELXL-2014/7 (Sheldrick 2014'
_refine_ls_goodness_of_fit_ref   1.041
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     434
_refine_ls_number_reflns         6531
_refine_ls_number_restraints     1
_refine_ls_restrained_S_all      1.041
_refine_ls_R_factor_all          0.0253
_refine_ls_R_factor_gt           0.0250
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0490P)^2^+0.1130P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0731
_refine_ls_wR_factor_ref         0.0734
_reflns_Friedel_coverage         0.814
_reflns_Friedel_fraction_full    0.883
_reflns_Friedel_fraction_max     0.846
_reflns_number_gt                6437
_reflns_number_total             6531
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            ja8b04703_si_003.cif
_cod_data_source_block           p20160517a
_cod_database_code               4132535
_chemical_oxdiff_formula         C13H14O3
_shelx_estimated_absorpt_t_max   0.874
_shelx_estimated_absorpt_t_min   0.838
_reflns_odcompleteness_completeness 99.04
_reflns_odcompleteness_iscentric 1
_reflns_odcompleteness_theta     78.87
_olex2_refinement_description
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H) groups, All C(H,H) groups
2.a Ternary CH refined with riding coordinates:
 C3(H3), C3B(H3B), C3A(H3A)
2.b Secondary CH2 refined with riding coordinates:
 C1(H1A,H1B), C4(H4A,H4B), C5(H5A,H5B), C13(H13A,H13B), C1B(H1BA,H1BB),
 C4B(H4BA,H4BB), C5B(H5BA,H5BB), C13B(H13C,H13D), C1A(H1AA,H1AB), C4A(H4AA,
 H4AB), C5A(H5AA,H5AB), C13A(H13E,H13F)
2.c Aromatic/amide H refined with riding coordinates:
 C8(H8), C11(H11), C12(H12), C8B(H8B), C11B(H11B), C12B(H12B), C8A(H8A),
 C11A(H11A), C12A(H12A)
2.d X=CH2 refined with riding coordinates:
 C6(H6A,H6B), C6B(H6BA,H6BB), C6A(H6AA,H6AB)
;
_shelx_res_checksum              16709
_shelx_hkl_checksum              41089
_shelx_shelxl_version_number     2014/7
_olex2_submission_special_instructions 'No special instructions were received'
_oxdiff_exptl_absorpt_empirical_details
;
Empirical correction (ABSPACK) includes:
- Absorption correction using spherical harmonics
- Frame scaling
- Detector area scaling
;
_oxdiff_exptl_absorpt_empirical_full_max 1.259
_oxdiff_exptl_absorpt_empirical_full_min 0.835