Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines.
Perryman, Michael S.; Earl, Matthew W. M.; Greatorex, Sam; Clarkson, Guy J.; Fox, David J.; Organic & biomolecular chemistry 13 (2015) 2360–2365; doi:10.1039/c4ob02311k

data_7154255
_publ_section_title
;
 Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type
 reactions with N-substituted diamines.
;
_journal_issue                   8
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              2360
_journal_page_last               2365
_journal_paper_doi               10.1039/c4ob02311k
_journal_volume                  13
_journal_year                    2015
_chemical_formula_moiety         'C18 H20 N2 O'
_chemical_formula_sum            'C18 H20 N2 O'
_chemical_formula_weight         280.36
_space_group_crystal_system      orthorhombic
_space_group_IT_number           29
_space_group_name_Hall           'P 2c -2ac'
_space_group_name_H-M_alt        'P c a 21'
_symmetry_space_group_name_Hall  'P 2c -2ac'
_symmetry_space_group_name_H-M   'P c a 21'
_atom_sites_solution_hydrogens   mixed
_atom_sites_solution_primary     direct
_audit_creation_date             2013-09-14
_audit_creation_method
;
  Olex2 1.2
  (compiled 2013.04.25 svn.r2679, GUI svn.r4466)
;
_audit_update_record
;
2014-09-02 deposited with the CCDC.
2014-12-16 downloaded from the CCDC.
;
_cell_angle_alpha                90
_cell_angle_beta                 90
_cell_angle_gamma                90
_cell_formula_units_Z            4
_cell_length_a                   27.3686(6)
_cell_length_b                   6.32664(13)
_cell_length_c                   8.74746(17)
_cell_measurement_reflns_used    3329
_cell_measurement_temperature    100(2)
_cell_measurement_theta_max      77.4240
_cell_measurement_theta_min      4.8410
_cell_volume                     1514.63(5)
_computing_cell_refinement
;
CrysAlisPro, Agilent Technologies,
Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET)
(compiled Feb  1 2013,16:14:44)
;
_computing_data_collection
;
CrysAlisPro, Agilent Technologies,
Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET)
(compiled Feb  1 2013,16:14:44)
;
_computing_data_reduction
;
CrysAlisPro, Agilent Technologies,
Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET)
(compiled Feb  1 2013,16:14:44)
;
_computing_molecular_graphics
;
O. V. Dolomanov, L. J. Bourhis, R. J. Gildea, J. A. K. Howard and H. Puschmann,
OLEX2: a complete structure solution, refinement and analysis program.
J. Appl. Cryst. (2009). 42, 339-341.
;
_computing_publication_material
;
O. V. Dolomanov, L. J. Bourhis, R. J. Gildea, J. A. K. Howard and H. Puschmann,
OLEX2: a complete structure solution, refinement and analysis program.
J. Appl. Cryst. (2009). 42, 339-341.
;
_computing_structure_refinement
;
SHELXL, G.M. Sheldrick, Acta Cryst.
(2008). A64, 112-122
;
_computing_structure_solution
;
XS, G.M. Sheldrick, Acta Cryst.
(2008). A64, 112-122
;
_diffrn_ambient_temperature      100(2)
_diffrn_detector_area_resol_mean 10.2833
_diffrn_measured_fraction_theta_full 0.9988
_diffrn_measured_fraction_theta_max 0.7542
_diffrn_measurement_details
;
  1 omega  -21.00   34.00   1.0000   15.0000
omega____ theta____ kappa____ phi______ frames
    -      -40.5282   38.0000 -120.0000 55

  2 omega -112.00  -15.00   1.0000   15.0000
omega____ theta____ kappa____ phi______ frames
    -      -40.5282  -57.0000  -60.0000 97

  3 omega  -26.00    0.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      -61.5000   30.0000    0.0000 26

  4 omega  -55.00   -2.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      -61.5000   45.0000 -150.0000 53

  5 omega   37.00   86.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000  -30.0000  120.0000 49

  6 omega   37.00   70.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000  -30.0000    0.0000 33

  7 omega   60.00   91.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000 -111.0000  150.0000 31

  8 omega   50.00   99.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000  -45.0000   30.0000 49

  9 omega   50.00   77.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000  -30.0000  150.0000 27

 10 omega   76.00  115.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000 -111.0000 -120.0000 39

 11 omega   62.00   91.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000  -30.0000   60.0000 29

 12 omega   42.00   90.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000  -30.0000  -90.0000 48

 13 omega   45.00  115.00   1.0000   60.0000
omega____ theta____ kappa____ phi______ frames
    -      115.0000 -111.0000   60.0000 70
;
_diffrn_measurement_device_type  'Xcalibur, Ruby, Gemini'
_diffrn_measurement_method       '\w scans'
_diffrn_orient_matrix_UB_11      0.0496463000
_diffrn_orient_matrix_UB_12      0.0523605000
_diffrn_orient_matrix_UB_13      0.0737583000
_diffrn_orient_matrix_UB_21      0.0263509000
_diffrn_orient_matrix_UB_22      -0.0712999000
_diffrn_orient_matrix_UB_23      -0.1468433000
_diffrn_orient_matrix_UB_31      -0.0032222000
_diffrn_orient_matrix_UB_32      0.2268999000
_diffrn_orient_matrix_UB_33      -0.0632127000
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_type           'Cu K\a'
_diffrn_radiation_wavelength     1.5418
_diffrn_reflns_av_R_equivalents  0.0194
_diffrn_reflns_av_unetI/netI     0.0199
_diffrn_reflns_Laue_measured_fraction_full 0.976
_diffrn_reflns_Laue_measured_fraction_max 1.000
_diffrn_reflns_limit_h_max       31
_diffrn_reflns_limit_h_min       -32
_diffrn_reflns_limit_k_max       7
_diffrn_reflns_limit_k_min       -5
_diffrn_reflns_limit_l_max       9
_diffrn_reflns_limit_l_min       -10
_diffrn_reflns_number            4385
_diffrn_reflns_point_group_measured_fraction_full 0.787
_diffrn_reflns_point_group_measured_fraction_max 0.807
_diffrn_reflns_theta_full        67.684
_diffrn_reflns_theta_max         66.587
_diffrn_reflns_theta_min         3.230
_diffrn_source                   'Enhance (Cu) X-ray Source'
_exptl_absorpt_coefficient_mu    0.602
_exptl_absorpt_correction_T_max  1.00000
_exptl_absorpt_correction_T_min  0.78987
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details
;
CrysAlisPro, Agilent Technologies,
Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET)
(compiled Feb  1 2013,16:14:44)
Empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            colourless
_exptl_crystal_colour_primary    colourless
_exptl_crystal_density_diffrn    1.229
_exptl_crystal_description       block
_exptl_crystal_F_000             600
_exptl_crystal_size_max          0.4
_exptl_crystal_size_mid          0.2
_exptl_crystal_size_min          0.08
_refine_diff_density_max         0.143
_refine_diff_density_min         -0.165
_refine_diff_density_rms         0.031
_refine_ls_abs_structure_details
;
 Flack x determined using 712 quotients [(I+)-(I-)]/[(I+)+(I-)]
 (Parsons and Flack (2004), Acta Cryst. A60, s61).
;
_refine_ls_abs_structure_Flack   0.2(2)
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.035
_refine_ls_hydrogen_treatment    mixed
_refine_ls_matrix_type           full
_refine_ls_number_parameters     193
_refine_ls_number_reflns         2162
_refine_ls_number_restraints     1
_refine_ls_restrained_S_all      1.034
_refine_ls_R_factor_all          0.0346
_refine_ls_R_factor_gt           0.0343
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0573P)^2^+0.3028P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0913
_refine_ls_wR_factor_ref         0.0915
_reflns_Friedel_coverage         0.503
_reflns_Friedel_fraction_full    0.568
_reflns_Friedel_fraction_max     0.583
_reflns_number_gt                2143
_reflns_number_total             2162
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            c4ob02311k2.cif
_cod_data_source_block           mp6
_cod_depositor_comments
'Adding full bibliography for 7154254--7154256.cif.'
_cod_original_cell_volume        1514.63(6)
_cod_database_code               7154255
_chemical_oxdiff_formula         'C20 H20 N2 O2'
_reflns_odcompleteness_completeness 99.88
_reflns_odcompleteness_iscentric 1
_reflns_odcompleteness_theta     69.95
_olex2_refinement_description
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H,H) groups, H2 of C2, H1 of C1, H3 of C3, H4 of C4, H5 of C5, H9 of
  C9, H15 of C15, H16 of C16, H17 of C17, H18 of C18, H19 of C19
 At 1.5 times of:
  H9A of C19
2.a Ternary CH refined with riding coordinates:
 C9(H9)
2.b Secondary CH2 refined with riding coordinates:
 C7(H7A,H7B), C8(H8A,H8B), C12(H12A,H12B), C13(H13A,H13B)
2.c Aromatic/amide H refined with riding coordinates:
 C1(H1), C2(H2), C3(H3), C4(H4), C5(H5), C15(H15), C16(H16), C17(H17),
 C18(H18), C19(H19)
;
_shelxl_version_number           2013-4