Acridine photocatalysis enables tricomponent direct decarboxylative amine construction.
Sui, Xianwei; Dang, Hang T.; Porey, Arka; Trevino, Ramon; Das, Arko; Fremin, Seth O.; Hughes, William B.; Thompson, William T.; Dhakal, Shree Krishna; Arman, Hadi D.; Larionov, Oleg V.; Chemical science 15 (2024) 9582–9590; doi:10.1039/d4sc02356k

data_1571693
_publ_section_title
;
 Acridine photocatalysis enables tricomponent direct decarboxylative amine
 construction.
;
_journal_issue                   25
_journal_name_full               'Chemical science'
_journal_page_first              9582
_journal_page_last               9590
_journal_paper_doi               10.1039/d4sc02356k
_journal_volume                  15
_journal_year                    2024
_chemical_formula_moiety         'C7 H12 O2, C18 H22 N2'
_chemical_formula_sum            'C25 H34 N2 O2'
_chemical_formula_weight         394.54
_space_group_crystal_system      triclinic
_space_group_IT_number           2
_space_group_name_Hall           '-P 1'
_space_group_name_H-M_alt        'P -1'
_atom_sites_solution_hydrogens   mixed
_atom_sites_solution_primary     dual
_audit_creation_date             2023-11-01
_audit_creation_method
;
Olex2 1.5-ac5-024
(compiled 2022.04.12 svn.rca3783a0 for Rigaku Oxford Diffraction, GUI svn.r6498)
;
_audit_update_record
;
2024-03-14 deposited with the CCDC.	2024-05-21 downloaded from the CCDC.
;
_cell_angle_alpha                93.448(2)
_cell_angle_beta                 90.414(2)
_cell_angle_gamma                96.639(2)
_cell_formula_units_Z            2
_cell_length_a                   9.2584(2)
_cell_length_b                   9.9261(2)
_cell_length_c                   11.8278(3)
_cell_measurement_reflns_used    10436
_cell_measurement_temperature    100.00(10)
_cell_measurement_theta_max      76.3830
_cell_measurement_theta_min      3.7360
_cell_volume                     1077.62(4)
_computing_cell_refinement       'CrysAlisPro 1.171.42.102a (Rigaku OD, 2023)'
_computing_data_collection       'CrysAlisPro 1.171.42.102a (Rigaku OD, 2023)'
_computing_data_reduction        'CrysAlisPro 1.171.42.102a (Rigaku OD, 2023)'
_computing_molecular_graphics    'Olex2 1.5-ac5-024 (Dolomanov et al., 2009)'
_computing_publication_material  'Olex2 1.5-ac5-024 (Dolomanov et al., 2009)'
_computing_structure_refinement  'SHELXL 2018/3 (Sheldrick, 2015)'
_computing_structure_solution    'SHELXT  (Sheldrick, 2015)'
_diffrn_ambient_environment      N~2~
_diffrn_ambient_temperature      100.00(10)
_diffrn_detector                 'Hybrid Pixel Array Detector'
_diffrn_detector_area_resol_mean 10.0000
_diffrn_detector_type            HyPix
_diffrn_measured_fraction_theta_full 0.998
_diffrn_measured_fraction_theta_max 0.948
_diffrn_measurement_details
;
List of Runs (angles in degrees, time in seconds):

  # Type    Start    End  Width  t~exp~   \w     \q     \k     \f   Frames
  1  \w     31.00 119.00   0.50    0.05    --   46.64  55.00-161.62  176
  2  \w     31.00 119.00   0.50    0.05    --   46.64  54.00-111.67  176
  3  \w     31.00 119.00   0.50    0.05    --   46.64  53.00 -38.00  176
  4  \w     32.00 121.00   0.50    0.05    --   46.64  31.00-148.00  178
  5  \w     33.00 119.00   0.50    0.05    --   46.64  44.00  50.50  172
  6  \w     31.00 119.00   0.50    0.05    --   46.64  53.00 103.67  176
  7  \w     31.00 119.00   0.50    0.05    --   46.64  53.00 148.93  176
  8  \w     34.00 101.00   0.50    0.15    --  106.92 -77.00  90.00  134
  9  \w     34.00  71.00   0.50    0.15    --  106.92 -61.00  90.00   74
 10  \w     34.00  71.00   0.50    0.15    --  106.92 -61.00   0.00   74
 11  \w     34.00  71.00   0.50    0.15    --  106.92 -61.00-150.00   74
 12  \w     34.00  71.00   0.50    0.15    --  106.92 -61.00-180.00   74
 13  \w     34.00  93.00   0.50    0.05    --   46.64-125.00 -90.00  118
 14  \w     37.00 112.00   0.50    0.15    --  106.92-125.00-180.00  150
 15  \w     37.00 112.00   0.50    0.15    --  106.92-125.00-150.00  150
 16  \w     37.00 112.00   0.50    0.15    --  106.92-125.00-120.00  150
 17  \w     37.00 112.00   0.50    0.15    --  106.92-125.00 -60.00  150
 18  \w     34.00 106.00   0.50    0.15    --  106.92 -94.00 -60.00  144
 19  \w     34.00 106.00   0.50    0.15    --  106.92 -94.00   0.00  144
 20  \w     37.00 112.00   0.50    0.15    --  106.92-125.00  90.00  150
 21  \w    -25.00  63.00   0.50    0.05    --   46.64 -57.00  30.00  176
 22  \w    -28.00  38.00   0.50    0.05    --   46.64 -31.00  51.00  132
 23  \w     92.00 178.00   0.50    0.15    --  106.92  31.00-148.00  172
 24  \w   -121.00 -31.00   0.50    0.05    --  -46.64 -31.00  51.00  180
 25  \w   -118.00 -83.00   0.50    0.05    --  -46.64 -57.00  60.00   70
 26  \w   -118.00 -31.00   0.50    0.05    --  -46.64 -52.00 -25.24  174
 27  \w    -85.00 -22.00   0.50    0.15    --  -91.75 125.00 -90.00  126
 28  \w   -101.00 -19.00   0.50    0.15    --  -91.75  77.00 -60.00  164
 29  \w    -71.00 -19.00   0.50    0.15    --  -91.75  61.00-120.00  104
 30  \w    -71.00 -19.00   0.50    0.15    --  -91.75  61.00-150.00  104
 31  \w    -38.00  28.00   0.50    0.05    --  -46.64  31.00-148.00  132
 32  \w    -51.00 -19.00   0.50    0.15    --  -91.75  45.00  30.00   64
 33  \w    -71.00 -19.00   0.50    0.15    --  -91.75  61.00  30.00  104
 34  \w   -167.00 -74.00   0.50    0.15    --  -91.75 -15.00 -90.00  186
 35  \w   -164.00 -77.00   0.50    0.15    --  -91.75 -45.00 -65.95  174
 36  \w   -164.00-101.00   0.50    0.15    --  -91.75 -77.00   0.00  126
 37  \w   -164.00-101.00   0.50    0.15    --  -91.75 -77.00  30.00  126
 38  \w   -166.00 -76.00   0.50    0.15    --  -91.75 -31.00  51.00  180
 39  \w   -164.00-100.00   0.50    0.15    --  -91.75 -94.00 150.00  128
;
_diffrn_measurement_device       'four-circle diffractometer'
_diffrn_measurement_device_type  'XtaLAB Synergy, Dualflex, HyPix'
_diffrn_measurement_method       '\w scans'
_diffrn_orient_matrix_type
'CrysAlisPro convention (1999,Acta A55,543-557)'
_diffrn_orient_matrix_UB_11      0.1597575000
_diffrn_orient_matrix_UB_12      0.0456902000
_diffrn_orient_matrix_UB_13      0.0344423000
_diffrn_orient_matrix_UB_21      -0.0149236000
_diffrn_orient_matrix_UB_22      0.1431657000
_diffrn_orient_matrix_UB_23      -0.0388962000
_diffrn_orient_matrix_UB_31      -0.0482017000
_diffrn_orient_matrix_UB_32      0.0438486000
_diffrn_orient_matrix_UB_33      0.1197113000
_diffrn_radiation_monochromator  mirror
_diffrn_radiation_probe          x-ray
_diffrn_radiation_type           'Cu K\a'
_diffrn_radiation_wavelength     1.54184
_diffrn_reflns_av_R_equivalents  0.0308
_diffrn_reflns_av_unetI/netI     0.0216
_diffrn_reflns_Laue_measured_fraction_full 0.998
_diffrn_reflns_Laue_measured_fraction_max 0.948
_diffrn_reflns_limit_h_max       11
_diffrn_reflns_limit_h_min       -11
_diffrn_reflns_limit_k_max       12
_diffrn_reflns_limit_k_min       -12
_diffrn_reflns_limit_l_max       14
_diffrn_reflns_limit_l_min       -12
_diffrn_reflns_number            20191
_diffrn_reflns_point_group_measured_fraction_full 0.998
_diffrn_reflns_point_group_measured_fraction_max 0.948
_diffrn_reflns_theta_full        67.684
_diffrn_reflns_theta_max         76.849
_diffrn_reflns_theta_min         3.744
_diffrn_source                   'micro-focus sealed X-ray tube'
_diffrn_source_type              'PhotonJet (Cu) X-ray Source'
_exptl_absorpt_coefficient_mu    0.598
_exptl_absorpt_correction_T_max  1.000
_exptl_absorpt_correction_T_min  0.667
_exptl_absorpt_correction_type   gaussian
_exptl_absorpt_process_details
;
CrysAlisPro 1.171.42.102a (Rigaku Oxford Diffraction, 2023)
Numerical absorption correction based on gaussian integration over
a multifaceted crystal model
Empirical absorption correction using spherical harmonics,
implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            'clear colourless'
_exptl_crystal_colour_lustre     clear
_exptl_crystal_colour_primary    colourless
_exptl_crystal_density_diffrn    1.216
_exptl_crystal_description       block
_exptl_crystal_F_000             428
_exptl_crystal_size_max          0.16
_exptl_crystal_size_mid          0.095
_exptl_crystal_size_min          0.071
_refine_diff_density_max         0.492
_refine_diff_density_min         -0.470
_refine_diff_density_rms         0.044
_refine_ls_extinction_coef       0.0017(4)
_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc^2^\l^3^/sin(2\q)]^-1/4^
_refine_ls_extinction_method     'SHELXL-2018/3 (Sheldrick 2018)'
_refine_ls_goodness_of_fit_ref   1.022
_refine_ls_hydrogen_treatment    mixed
_refine_ls_matrix_type           full
_refine_ls_number_parameters     296
_refine_ls_number_reflns         4297
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.022
_refine_ls_R_factor_all          0.0579
_refine_ls_R_factor_gt           0.0521
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0500P)^2^+0.7500P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1251
_refine_ls_wR_factor_ref         0.1297
_reflns_Friedel_coverage         0.000
_reflns_number_gt                3797
_reflns_number_total             4297
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            d4sc02356k2.cif
_cod_data_source_block           hpd800_auto
_cod_depositor_comments
'Adding full bibliography for 1571691--1571695.cif.'
_cod_database_code               1571693
_shelx_shelxl_version_number     2018/3
_chemical_oxdiff_formula         'C H N'
_chemical_oxdiff_usercomment     'sample 4'
_shelx_estimated_absorpt_t_max   0.959
_shelx_estimated_absorpt_t_min   0.910
_olex2_refinement_description
;
1. Fixed Uiso
 At 1.2 times of:
  All C(H,H) groups, H6 of C6, H5 of C5, H19B of C19B, H19A of C19A, H4 of C4,
   H9 of C9, H13 of C13, H1A of C1, H3 of C3, H10 of C10, H11 of C11, H7 of C7,
  H12 of C12, All C(H,H,H) groups, All C(H,H,H,H) groups
 At 1.5 times of:
  H1B of C22B
2. Others
 Fixed Sof: H20A(0.55) H20B(0.55) H20C(0.45) H20D(0.45) H23C(0.5) H23D(0.5)
 H23A(0.5) H23B(0.5) H21A(0.5) H21B(0.5) H21C(0.5) H21D(0.5) C24A(0.55)
 H24A(0.55) H24B(0.55) C24B(0.45) H24C(0.45) H24D(0.45) C22A(0.5) H22A(0.5)
 H22B(0.5) C22B(0.5) H22C(0.5) H22D(0.5) C19A(0.55) H19A(0.55) C19B(0.45)
 H19B(0.45)
3.a Ternary CH refined with riding coordinates:
 C1(H1A), C13(H13), C19A(H19A), C19B(H19B)
3.b Secondary CH2 refined with riding coordinates:
 C17(H17A,H17B), C18(H18A,H18B), C20(H20A,H20B), C20(H20C,H20D), C16(H16A,
 H16B), C14(H14A,H14B), C15(H15A,H15B), C23(H23C,H23D), C23(H23A,H23B),
 C21(H21A,H21B), C21(H21C,H21D), C24A(H24A,H24B), C24B(H24C,H24D), C22A(H22A,
 H22B), C22B(H22C,H22D)
3.c Aromatic/amide H refined with riding coordinates:
 C12(H12), C11(H11), C9(H9), C3(H3), C4(H4), C10(H10), C7(H7), C6(H6), C5(H5)
;
_shelx_res_checksum              83510
_olex2_exptl_crystal_mounting_method 'nylon loop'
_olex2_submission_special_instructions 'No special instructions were received'
_oxdiff_exptl_absorpt_empirical_details
;
Empirical correction (ABSPACK) includes:
- Absorption correction using spherical harmonics
- Frame scaling
- Detector area scaling
- B-factor correction
;
_oxdiff_exptl_absorpt_empirical_full_max 1.128
_oxdiff_exptl_absorpt_empirical_full_min 0.893