Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/Linked-BINOL Complex: Synthesis of Either anti- or syn-β-Amino Alcohols
Shigeki Matsunaga; Takamasa Yoshida; Hiroyuki Morimoto; Naoya Kumagai; Masakatsu Shibasaki; Journal of the American Chemical Society 126 (2004) 8777–8785; doi:10.1021/ja0482435

data_4112754
_publ_section_title
;
 Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using
 a Et2Zn/Linked-BINOL Complex: Synthesis of Either anti- or syn-\b-Amino
 Alcohols
;
_journal_name_full               'Journal of the American Chemical Society'
_journal_page_first              8777
_journal_page_last               8785
_journal_paper_doi               10.1021/ja0482435
_journal_volume                  126
_journal_year                    2004
_chemical_formula_moiety         'C29 H28 N O4 P '
_chemical_formula_sum            'C29 H28 N O4 P'
_chemical_formula_weight         485.52
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_symmetry_cell_setting           monoclinic
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_symmetry_space_group_name_Hall  'P 2yb'
_symmetry_space_group_name_H-M   'P 1 21 1'
_cell_angle_alpha                90
_cell_angle_beta                 108.307(2)
_cell_angle_gamma                90
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_cell_length_b                   8.7892(7)
_cell_length_c                   13.566(1)
_cell_measurement_reflns_used    7748
_cell_measurement_temperature    285.2
_cell_measurement_theta_max      27.4
_cell_measurement_theta_min      2.3
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_computing_cell_refinement       PROCESS-AUTO
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_computing_publication_material  'teXsan Ver. 1.10'
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_diffrn_measurement_device_type  'Rigaku RAXIS-RAPID Imaging Plate'
_diffrn_measurement_method       \w
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_diffrn_reflns_limit_h_max       14
_diffrn_reflns_limit_h_min       -14
_diffrn_reflns_limit_k_max       11
_diffrn_reflns_limit_k_min       -11
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_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   '(Higashi, 1995)'
_exptl_crystal_colour            colorless
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_exptl_crystal_size_mid          0.200
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_refine_diff_density_min         -0.30
_refine_ls_abs_structure_Flack   1.6(4)
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   0.737
_refine_ls_hydrogen_treatment    refall
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_refine_ls_R_factor_gt           0.0386
_refine_ls_shift/su_max          0.9668
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w = 1/[\s^2^(Fo^2^) + (0.05000(Max(Fo^2^,0) + 2Fc^2^)/3)^2^]'
_refine_ls_weighting_scheme      calc
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_reflns_threshold_expression     F^2^>2.0\s(F^2^)
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_cod_data_source_block           030205NK
_cod_original_cell_volume        1267.4(2)
_cod_original_formula_sum        'C29 H28 N O4 P '
_cod_database_code               4112754