DNA/BSA binding, antidiabetic and antioxidant studies of copper(ii) complexes derived from ONO-tridentate Schiff bases and diimines as auxiliary ligands
Oladipo, Segun D.; Adeleke, Adesola A.; Olofisan, Kolawole A.; Omondi, Bernard; Luckay, Robert C.; RSC Advances 16 (2026) 18709–18723; doi:10.1039/D6RA01650B

data_7251876
_publ_section_title
;
 DNA/BSA binding, antidiabetic and antioxidant studies of copper(ii)
 complexes derived from ONO-tridentate Schiff bases and diimines as
 auxiliary ligands
;
_journal_issue                   21
_journal_name_full               'RSC Advances'
_journal_page_first              18709
_journal_page_last               18723
_journal_paper_doi               10.1039/D6RA01650B
_journal_volume                  16
_journal_year                    2026
_chemical_formula_moiety         'C32 H25 Cu N3 O2, C H4 O'
_chemical_formula_sum            'C33 H29 Cu N3 O3'
_chemical_formula_weight         579.13
_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_Hall           '-P 2yn'
_space_group_name_H-M_alt        'P 1 21/n 1'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     'intrinsic phasing'
_atom_sites_solution_secondary   none
_audit_creation_method           SHELXL-2019/3
_audit_update_record
;
2026-02-11 deposited with the CCDC.	2026-04-02 downloaded from the CCDC.
;
_cell_angle_alpha                90
_cell_angle_beta                 108.352(2)
_cell_angle_gamma                90
_cell_formula_units_Z            4
_cell_length_a                   9.6459(6)
_cell_length_b                   20.2675(13)
_cell_length_c                   14.4479(9)
_cell_measurement_reflns_used    9958
_cell_measurement_temperature    111(2)
_cell_measurement_theta_max      25.48
_cell_measurement_theta_min      2.25
_cell_volume                     2680.9(3)
_computing_cell_refinement       'SAINT V8.40A (Bruker, 2019)'
_computing_data_collection       'APEX4 (Bruker, 2021)'
_computing_data_reduction        'SAINT V8.40A (Bruker, 2019)'
_computing_molecular_graphics
'X-Seed (Barbour, 2020; Atwood & Barbour, 2003)'
_computing_structure_refinement  'SHELXL-2019/2 (Sheldrick, 2019)'
_computing_structure_solution    'SHELXT 2018/2 (Sheldrick, 2018)'
_diffrn_ambient_temperature      111(2)
_diffrn_measured_fraction_theta_full 0.999
_diffrn_measured_fraction_theta_max 0.995
_diffrn_measurement_device       'three-circle diffractometer'
_diffrn_measurement_device_type  'Bruker SMART APEX CCD'
_diffrn_measurement_method       '\f and \w scans'
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_reflns_av_R_equivalents  0.0477
_diffrn_reflns_av_unetI/netI     0.0257
_diffrn_reflns_Laue_measured_fraction_full 0.999
_diffrn_reflns_Laue_measured_fraction_max 0.995
_diffrn_reflns_limit_h_max       11
_diffrn_reflns_limit_h_min       -12
_diffrn_reflns_limit_k_max       25
_diffrn_reflns_limit_k_min       -25
_diffrn_reflns_limit_l_max       17
_diffrn_reflns_limit_l_min       -18
_diffrn_reflns_number            64228
_diffrn_reflns_point_group_measured_fraction_full 0.999
_diffrn_reflns_point_group_measured_fraction_max 0.995
_diffrn_reflns_theta_full        25.242
_diffrn_reflns_theta_max         26.420
_diffrn_reflns_theta_min         1.793
_diffrn_source                   'microfocus sealed tube'
_diffrn_standards_number         0
_exptl_absorpt_coefficient_mu    0.856
_exptl_absorpt_correction_T_max  1.000
_exptl_absorpt_correction_T_min  0.914
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   'SADABS, 2016/2'
_exptl_crystal_colour            orange
_exptl_crystal_density_diffrn    1.435
_exptl_crystal_description       plate
_exptl_crystal_F_000             1204
_exptl_crystal_size_max          0.483
_exptl_crystal_size_mid          0.221
_exptl_crystal_size_min          0.074
_refine_diff_density_max         1.063
_refine_diff_density_min         -0.442
_refine_diff_density_rms         0.068
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.040
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     366
_refine_ls_number_reflns         5477
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.040
_refine_ls_R_factor_all          0.0614
_refine_ls_R_factor_gt           0.0479
_refine_ls_shift/su_max          0.002
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0456P)^2^+4.7625P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1139
_refine_ls_wR_factor_ref         0.1210
_reflns_Friedel_coverage         0.000
_reflns_number_gt                4480
_reflns_number_total             5477
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            d6ra01650b2.cif
_cod_data_source_block           Cu_HNM_MP
_cod_original_sg_symbol_H-M      'P 21/n'
_cod_database_code               7251876
_shelx_shelxl_version_number     2019/3
_shelx_estimated_absorpt_t_min   0.683
_shelx_estimated_absorpt_t_max   0.939
_shelx_res_checksum              65774