Concise Total Synthesis of (-)-Deoxocuscohygrine and (-)-Dihydrocuscohygrine
Takayasu Yamauchi; Sachi Hagiwara; Kimio Higashiyama; Journal of Organic Chemistry 73 (2008) 9784–9787; doi:10.1021/jo801700f

data_4023931
_publ_section_title
;
 Concise Total Synthesis of (-)-Deoxocuscohygrine and
 (-)-Dihydrocuscohygrine
;
_journal_name_full               'Journal of Organic Chemistry'
_journal_page_first              9784
_journal_page_last               9787
_journal_paper_doi               10.1021/jo801700f
_journal_volume                  73
_journal_year                    2008
_chemical_formula_moiety         'C34 H44 N2 O3 '
_chemical_formula_sum            'C34 H44 N2 O3'
_chemical_formula_weight         528.73
_space_group_IT_number           4
_symmetry_cell_setting           monoclinic
_symmetry_Int_Tables_number      4
_symmetry_space_group_name_Hall  'P 2yb'
_symmetry_space_group_name_H-M   'P 1 21 1'
_audit_creation_date             2003-03-19
_audit_creation_method           'by CrystalStructure v3.10'
_cell_angle_alpha                90
_cell_angle_beta                 105.21(2)
_cell_angle_gamma                90
_cell_formula_units_Z            2
_cell_length_a                   16.481(4)
_cell_length_b                   7.997(3)
_cell_length_c                   11.861(3)
_cell_measurement_reflns_used    25
_cell_measurement_temperature    298.1
_cell_measurement_theta_max      29.1
_cell_measurement_theta_min      25.3
_cell_volume                     1508.6(7)
_computing_cell_refinement       WinAFC
_computing_data_collection       WinAFC
_computing_data_reduction        CrystalStructure
_computing_publication_material  'CrystalStructure Ver. 3.10'
_computing_structure_refinement  CRYSTALS
_computing_structure_solution    SIR92
_diffrn_measured_fraction_theta_full 0.9997
_diffrn_measured_fraction_theta_max 0.9997
_diffrn_measurement_device_type  'Rigaku AFC7R'
_diffrn_measurement_method       \w-2\q
_diffrn_radiation_type           'Cu K\a'
_diffrn_radiation_wavelength     1.5418
_diffrn_reflns_limit_h_max       19
_diffrn_reflns_limit_h_min       0
_diffrn_reflns_limit_k_max       0
_diffrn_reflns_limit_k_min       -9
_diffrn_reflns_limit_l_max       13
_diffrn_reflns_limit_l_min       -14
_diffrn_reflns_number            3070
_diffrn_reflns_theta_full        67.98
_diffrn_reflns_theta_max         67.98
_diffrn_standards_decay_%        2.00
_diffrn_standards_interval_count 150
_diffrn_standards_number         3
_exptl_absorpt_coefficient_mu    0.577
_exptl_absorpt_correction_type   none
_exptl_crystal_colour            colorless
_exptl_crystal_density_diffrn    1.164
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       prismatic
_exptl_crystal_F_000             572.00
_exptl_crystal_size_max          0.30
_exptl_crystal_size_mid          0.30
_exptl_crystal_size_min          0.20
_refine_diff_density_max         0.19
_refine_diff_density_min         -0.19
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   4.547
_refine_ls_hydrogen_treatment    refall
_refine_ls_number_parameters     396
_refine_ls_number_reflns         2726
_refine_ls_R_factor_gt           0.0500
_refine_ls_shift/su_max          0.0000
_refine_ls_structure_factor_coef F
_refine_ls_weighting_details     'w = 1.0'
_refine_ls_weighting_scheme      unit
_refine_ls_wR_factor_ref         0.0570
_reflns_number_gt                2726
_reflns_number_total             2960
_reflns_threshold_expression     F^2^>2.0\s(F^2^)
_cod_data_source_file            jo801700f_si_001.cif
_cod_data_source_block           '_PSU-1'
_cod_original_formula_sum        'C34 H44 N2 O3 '
_cod_database_code               4023931