Chiral Brønsted acid-catalyzed Friedel-Crafts alkylation of electron-rich arenes with in situ-generated ortho-quinone methides: highly enantioselective synthesis of diarylindolylmethanes and triarylmethanes.
Saha, Satyajit; Alamsetti, Santosh Kumar; Schneider, Christoph; Chemical communications (Cambridge, England) 51 (2015) 1461–1464; doi:10.1039/c4cc08559k

data_7116228
_publ_section_title
;
 Chiral Br\/onsted acid-catalyzed Friedel-Crafts alkylation of
 electron-rich arenes with in situ-generated ortho-quinone methides:
 highly enantioselective synthesis of diarylindolylmethanes and
 triarylmethanes.
;
_journal_issue                   8
_journal_name_full               'Chemical communications (Cambridge, England)'
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_journal_page_last               1464
_journal_paper_doi               10.1039/c4cc08559k
_journal_volume                  51
_journal_year                    2015
_chemical_absolute_configuration ad
_chemical_formula_sum            'C28 H23 N O2'
_chemical_formula_weight         405.47
_chemical_melting_point          363.15
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' (S)-2-([1,1'-biphenyl]-2-yl(1H-indol-3-yl)methyl)-4-methoxyphenol '
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2014-10-10 deposited with the CCDC.
2014-12-02 downloaded from the CCDC.
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        CrysAlisPro, Agilent Technologies,
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 ORTEP3 for Windows
 L. J. Farrugia, J. Appl. Crystallogr. 1997, 30, 565.
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 WINGX
 L.J. Farrugia,
 J. Appl. Cryst., 2012, 45, 849-854.
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 SHELXS-2014
 Program for Crystal Structure Analysis (Release 2014-3)
 G. M. Sheldrick, Instit\"ut f\"ur Anorganische Chemie der Universit\"at,
 Tammanstrasse 4, D-3400 G\"ottingen, Germany.
 G. M. Sheldrick, Acta. Cryst., 2008, A64, 112 - 122
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        CrysAlisPro, Agilent Technologies,
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        (compiled Jun  2 2014,16:24:16)
        Empirical absorption correction using spherical harmonics,
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        Empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
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_exptl_crystal_colour            'clear colourless'
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_exptl_crystal_size_max          0.4
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 Flack x determined using 1579 quotients [(I+)-(I-)]/[(I+)+(I-)]
 (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259).
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_refine_ls_abs_structure_Flack   -0.01(4)
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'w=1/[\s^2^(Fo^2^)+(0.0439P)^2^+0.3197P] where P=(Fo^2^+2Fc^2^)/3'
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