Synthesis of thiazolo[2,3-b]quinazoline derivatives via base-promoted cascade bicyclization of o-alkenylphenyl isothiocyanates with propargylamines.
Miao, Jiankang; Sang, Xiaoyan; Wang, Yi; Deng, Shufeng; Hao, Wenyan; Organic & biomolecular chemistry 17 (2019) 6994–6997; doi:10.1039/c9ob01098j

data_7156956
_publ_section_title
;
 Synthesis of thiazolo[2,3-b]quinazoline derivatives via base-promoted
 cascade bicyclization of o-alkenylphenyl isothiocyanates with
 propargylamines.
;
_journal_issue                   29
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              6994
_journal_page_last               6997
_journal_paper_doi               10.1039/c9ob01098j
_journal_volume                  17
_journal_year                    2019
_chemical_formula_sum            'C20 H18 N2 O2 S'
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_symmetry_space_group_name_Hall  '-P 2ybc'
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;
2019-04-04 deposited with the CCDC.    2019-07-04 downloaded from the CCDC.
;
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_diffrn_source                   'micro-focus sealed X-ray tube'
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_exptl_absorpt_process_details
;
CrysAlisPro 1.171.39.37b (Rigaku Oxford Diffraction, 2017)
Empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            COLORLESS
_exptl_crystal_density_diffrn    1.357
_exptl_crystal_description       BLCOK
_exptl_crystal_F_000             736
_exptl_crystal_size_max          0.100
_exptl_crystal_size_mid          0.090
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_refine_ls_extinction_method     none
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_refine_ls_number_reflns         3506
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.068
_refine_ls_R_factor_all          0.0598
_refine_ls_R_factor_gt           0.0470
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0418P)^2^+0.7193P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1060
_refine_ls_wR_factor_ref         0.1125
_reflns_Friedel_coverage         0.000
_reflns_number_gt                2891
_reflns_number_total             3506
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            c9ob01098j2.cif
_cod_data_source_block           MJK80-1-3
_cod_depositor_comments          'Adding full bibliography for 7156956.cif.'
_cod_database_code               7156956
_shelx_shelxl_version_number     2014/7
_shelx_estimated_absorpt_t_min   0.980
_shelx_estimated_absorpt_t_max   0.988
_shelx_res_checksum              73058
_shelx_hkl_checksum              65888