Asymmetric direct vinylogous Michael additions of allyl alkyl ketones to maleimides through dienamine catalysis.
Zhan, Gu; He, Qing; Yuan, Xin; Chen, Ying-Chun; Organic letters 16 (2014) 6000–6003; doi:10.1021/ol503017h

data_1518153
_publ_section_title
;
 Asymmetric direct vinylogous Michael additions of allyl alkyl ketones to
 maleimides through dienamine catalysis.
;
_journal_issue                   22
_journal_name_full               'Organic letters'
_journal_page_first              6000
_journal_page_last               6003
_journal_paper_doi               10.1021/ol503017h
_journal_volume                  16
_journal_year                    2014
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_chemical_formula_sum            'C20 H22 Br N O3'
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;
CrysAlisPro, Agilent Technologies,
Version 1.171.36.21 (release 14-08-2012 CrysAlis171 .NET)
(compiled Sep 14 2012,17:21:16)
Empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            colourless
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_exptl_crystal_description       block
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_exptl_crystal_size_max          0.370
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_refine_diff_density_min         -0.460
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;
 Flack x determined using 2220 quotients [(I+)-(I-)]/[(I+)+(I-)]
 (Parsons and Flack (2004), Acta Cryst. A60, s61).
;
_refine_ls_abs_structure_Flack   0.007(9)
_refine_ls_extinction_method     none
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_refine_ls_number_reflns         6465
_refine_ls_number_restraints     38
_refine_ls_restrained_S_all      1.084
_refine_ls_R_factor_all          0.0580
_refine_ls_R_factor_gt           0.0528
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0952P)^2^+0.8655P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1552
_refine_ls_wR_factor_ref         0.1625
_reflns_Friedel_coverage         0.710
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_reflns_Friedel_fraction_max     0.848
_reflns_number_gt                5765
_reflns_number_total             6465
_reflns_threshold_expression     'I > 2\s(I)'
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_cod_data_source_block           4o
_cod_depositor_comments          'Adding full bibliography for 1518153.cif.'
_cod_database_code               1518153
_shelx_estimated_absorpt_t_min   0.388
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_shelxl_version_number           2013-4
_shelx_res_checksum              90869
_shelx_hkl_checksum              83263