Copper-catalyzed aerobic cyclizations of tetrahydroisoquinolines with bromoketones and alkenes for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines.
Wang, Wenhui; Sun, Jinwei; Hu, Huayou; Liu, Yun; Organic & biomolecular chemistry 16 (2018) 1651–1658; doi:10.1039/c7ob03048g

data_7156101
_publ_section_title
;
 Copper-catalyzed aerobic cyclizations of tetrahydroisoquinolines with
 bromoketones and alkenes for the synthesis of
 5,6-dihydropyrrolo[2,1-a]isoquinolines.
;
_journal_issue                   10
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              1651
_journal_page_last               1658
_journal_paper_doi               10.1039/c7ob03048g
_journal_volume                  16
_journal_year                    2018
_chemical_formula_sum            'C32 H23 N O2'
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_audit_update_record
;
2017-11-21 deposited with the CCDC.
2018-02-02 downloaded from the CCDC.
;
_cell_angle_alpha                108.1050(16)
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_cell_angle_gamma                108.7120(15)
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_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_diffrn_ambient_temperature      296(2)
_diffrn_measured_fraction_theta_full 0.986
_diffrn_measured_fraction_theta_max 0.986
_diffrn_measurement_device_type  'Enraf--Nonius CAD-4'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
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_exptl_crystal_colour            colorless
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_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[\s^2^(Fo^2^)+(0.0400P)^2^+0.0000P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1056
_refine_ls_wR_factor_ref         0.1145
_reflns_number_gt                2640
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_reflns_threshold_expression     >2sigma(I)
_cod_data_source_file            c7ob03048g2.cif
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_cod_depositor_comments          'Adding full bibliography for 7156101.cif.'
_cod_original_cell_volume        1215.9(7)
_cod_database_code               7156101