Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.
Roscales, Silvia; Bechmann, Nicole; Weiss, Daniel Holger; Köckerling, Martin; Pietzsch, Jens; Kniess, Torsten; MedChemComm 9 (2018) 534–544; doi:10.1039/c7md00575j

data_7121289
_publ_section_title
;
 Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar
 cycloaddition of nitrile oxides with alkynes - synthesis and COX-2
 inhibition activity.
;
_journal_issue                   3
_journal_name_full               MedChemComm
_journal_page_first              534
_journal_page_last               544
_journal_paper_doi               10.1039/c7md00575j
_journal_volume                  9
_journal_year                    2018
_chemical_formula_moiety         'C19 H20 F N O3 S Si'
_chemical_formula_sum            'C19 H20 F N O3 S Si'
_chemical_formula_weight         389.51
_chemical_name_systematic
3-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-5-(trimethylsilyl)isoxazole
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_space_group_name_Hall           '-P 1'
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_audit_update_record
;
2016-06-01 deposited with the CCDC.
2018-02-13 downloaded from the CCDC.
;
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'w=1/[\s^2^(Fo^2^)+(0.0549P)^2^] where P=(Fo^2^+2Fc^2^)/3'
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'Adding full bibliography for 7121289--7121290.cif.'
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