Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.
Pichler, Verena; Mayr, Josef; Heffeter, Petra; Dömötör, Orsolya; Enyedy, Éva A; Hermann, Gerrit; Groza, Diana; Köllensperger, Gunda; Galanksi, Markus; Berger, Walter; Keppler, Bernhard K.; Kowol, Christian R.; Chemical communications (Cambridge, England) 49 (2013) 2249–2251; doi:10.1039/c3cc39258a

data_7112318
_publ_section_title
;
 Maleimide-functionalised platinum(IV) complexes as a synthetic platform
 for targeted drug delivery.
;
_journal_issue                   22
_journal_name_full
'Chemical communications (Cambridge, England)'
_journal_page_first              2249
_journal_page_last               2251
_journal_paper_doi               10.1039/c3cc39258a
_journal_volume                  49
_journal_year                    2013
_chemical_formula_moiety         'C16 H22 Cl2 N6 O8 Pt'
_chemical_formula_sum            'C16 H22 Cl2 N6 O8 Pt'
_chemical_formula_weight         692.39
_chemical_name_systematic
;
(OC-6-33)-Dichlorido(ethane-1,2-diamine)[bis(2-(2,5-dioxo-2,5-
dihydro-1H-pyrrol-1-yl)ethylcarbamoyloxy)platinum(IV)]
;
_space_group_IT_number           15
_symmetry_cell_setting           monoclinic
_symmetry_space_group_name_Hall  '-C 2yc'
_symmetry_space_group_name_H-M   'C 1 2/c 1'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_audit_creation_method           SHELXL-97
_cell_angle_alpha                90.00
_cell_angle_beta                 106.782(2)
_cell_angle_gamma                90.00
_cell_formula_units_Z            4
_cell_length_a                   26.9636(16)
_cell_length_b                   7.7770(4)
_cell_length_c                   11.3395(6)
_cell_measurement_reflns_used    7753
_cell_measurement_temperature    150(2)
_cell_measurement_theta_max      30.04
_cell_measurement_theta_min      2.73
_cell_volume                     2276.6(2)
_computing_cell_refinement       'Bruker SAINT'
_computing_data_collection       'Bruker APEX2'
_computing_data_reduction        'Bruker SAINT'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 2008)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 2008)'
_diffrn_ambient_temperature      150(2)
_diffrn_measured_fraction_theta_full 0.998
_diffrn_measured_fraction_theta_max 0.998
_diffrn_measurement_device_type  'Bruker X8 APEXII CCD'
_diffrn_measurement_method       '\f and \w scans'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_reflns_av_R_equivalents  0.0324
_diffrn_reflns_av_sigmaI/netI    0.0258
_diffrn_reflns_limit_h_max       35
_diffrn_reflns_limit_h_min       -35
_diffrn_reflns_limit_k_max       10
_diffrn_reflns_limit_k_min       -10
_diffrn_reflns_limit_l_max       14
_diffrn_reflns_limit_l_min       -14
_diffrn_reflns_number            12249
_diffrn_reflns_theta_full        27.99
_diffrn_reflns_theta_max         27.99
_diffrn_reflns_theta_min         2.74
_exptl_absorpt_coefficient_mu    6.454
_exptl_absorpt_correction_T_max  0.8818
_exptl_absorpt_correction_T_min  0.5114
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   SADABS
_exptl_crystal_colour            colorless
_exptl_crystal_density_diffrn    2.020
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       plate
_exptl_crystal_F_000             1344
_exptl_crystal_size_max          0.12
_exptl_crystal_size_mid          0.10
_exptl_crystal_size_min          0.02
_refine_diff_density_max         1.166
_refine_diff_density_min         -0.591
_refine_diff_density_rms         0.103
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.007
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     150
_refine_ls_number_reflns         2752
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.007
_refine_ls_R_factor_all          0.0227
_refine_ls_R_factor_gt           0.0181
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[\s^2^(Fo^2^)+(0.0271P)^2^+0.0000P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0423
_refine_ls_wR_factor_ref         0.0438
_reflns_number_gt                2538
_reflns_number_total             2752
_reflns_threshold_expression     >2sigma(I)
_cod_duplicate_entry             7108929
_cod_data_source_file            c3cc39258a.txt
_cod_data_source_block           JOMA081
_cod_original_sg_symbol_H-M      C2/c
_cod_database_code               7112318