Influence of the Spacer Length on thein VitroAnticancer Activity of Dinuclear Ruthenium−Arene Compounds
Mendoza-Ferri, Maria-Grazia; Hartinger, Christian G.; Eichinger, Rene E.; Stolyarova, Natalya; Severin, Kay; Jakupec, Michael A.; Nazarov, Alexey A.; Keppler, Bernhard K.; Organometallics 27 (2008) 2405–; doi:10.1021/om800207t

data_4071528
_publ_section_title
;
 Influence of the Spacer Length on thein VitroAnticancer Activity of
 Dinuclear Ruthenium&#x2212;Arene Compounds
;
_journal_issue                   11
_journal_name_full               Organometallics
_journal_page_first              2405
_journal_paper_doi               10.1021/om800207t
_journal_volume                  27
_journal_year                    2008
_chemical_formula_sum            'C40 H52 Cl8 N2 O4 Ru2'
_chemical_formula_weight         1110.58
_chemical_name_systematic
; 
1,6-Bis{chloro[3-(oxo-kappaO)-2-methyl-4-pyridinonato-kappaO4](eta^6^-
p-isopropyltoluene)ruthenium}hexane chloroform solvate
;
_space_group_IT_number           2
_symmetry_cell_setting           triclinic
_symmetry_space_group_name_Hall  '-P 1'
_symmetry_space_group_name_H-M   'P -1'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_audit_creation_method           SHELXL-97
_cell_angle_alpha                69.527(8)
_cell_angle_beta                 83.300(10)
_cell_angle_gamma                88.409(8)
_cell_formula_units_Z            1
_cell_length_a                   9.7494(13)
_cell_length_b                   10.9847(12)
_cell_length_c                   11.4996(14)
_cell_measurement_temperature    100(2)
_cell_volume                     1145.8(3)
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_diffrn_ambient_temperature      100(2)
_diffrn_measured_fraction_theta_full 0.999
_diffrn_measured_fraction_theta_max 0.999
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_reflns_av_R_equivalents  0.0641
_diffrn_reflns_av_sigmaI/netI    0.0576
_diffrn_reflns_limit_h_max       12
_diffrn_reflns_limit_h_min       -12
_diffrn_reflns_limit_k_max       14
_diffrn_reflns_limit_k_min       -14
_diffrn_reflns_limit_l_max       14
_diffrn_reflns_limit_l_min       -14
_diffrn_reflns_number            23112
_diffrn_reflns_theta_full        27.50
_diffrn_reflns_theta_max         27.50
_diffrn_reflns_theta_min         2.67
_exptl_absorpt_coefficient_mu    1.167
_exptl_absorpt_correction_T_max  0.9884
_exptl_absorpt_correction_T_min  0.8002
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   SADABS
_exptl_crystal_colour            orange
_exptl_crystal_density_diffrn    1.610
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       plate
_exptl_crystal_F_000             562
_exptl_crystal_size_max          0.20
_exptl_crystal_size_mid          0.08
_exptl_crystal_size_min          0.01
_refine_diff_density_max         1.703
_refine_diff_density_min         -1.627
_refine_diff_density_rms         0.129
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.059
_refine_ls_hydrogen_treatment    constr
_refine_ls_matrix_type           full
_refine_ls_number_parameters     257
_refine_ls_number_reflns         5263
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.059
_refine_ls_R_factor_all          0.0697
_refine_ls_R_factor_gt           0.0453
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[\s^2^(Fo^2^)+(0.0550P)^2^+1.4362P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1057
_refine_ls_wR_factor_ref         0.1134
_reflns_number_gt                4065
_reflns_number_total             5263
_reflns_threshold_expression     >2sigma(I)
_cod_data_source_file            om800207t-file002.cif
_cod_data_source_block           MGF116
_cod_original_cell_volume        1145.8(2)
_cod_original_sg_symbol_H-M      P-1
_cod_database_code               4071528