Stereoselective synthesis of <i>gem</i>-dihalopiperidines <i>via</i> the halo-aza-Prins cyclization reaction: access to piperidin-4-ones and pyridines.
Bora, Surjya Kumar; Biswas, Subhamoy; Behera, Bipin Kumar; Saikia, Anil K.; Organic & biomolecular chemistry 22 (2024) 3893–3903; doi:10.1039/d4ob00338a

data_7159903
_publ_section_title
;
 Stereoselective synthesis of <i>gem</i>-dihalopiperidines <i>via</i> the
 halo-aza-Prins cyclization reaction: access to piperidin-4-ones and
 pyridines.
;
_journal_issue                   19
_journal_name_full               'Organic &amp; biomolecular chemistry'
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_journal_page_last               3903
_journal_paper_doi               10.1039/d4ob00338a
_journal_volume                  22
_journal_year                    2024
_chemical_formula_sum            'C18 H18 Br Cl2 N O2 S'
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_audit_update_record
;
2023-12-14 deposited with the CCDC.	2024-04-16 downloaded from the CCDC.
;
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_computing_structure_refinement  'SHELXL-2019/1 (Sheldrick, 2019)'
_diffrn_ambient_temperature      298(2)
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_diffrn_measurement_device_type  'Bruker APEX-II CCD'
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_exptl_absorpt_coefficient_mu    2.567
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_exptl_crystal_description       Block
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_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.1146P)^2^+4.8817P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
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_reflns_number_gt                3813
_reflns_number_total             4681
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            d4ob00338a3.cif
_cod_data_source_block           surjya_NTs_0ma_a
_cod_depositor_comments          'Adding full bibliography for 7159903.cif.'
_cod_original_sg_symbol_H-M      'P 21/c'
_cod_database_code               7159903
_shelx_shelxl_version_number     2019/1
_shelx_res_checksum              4558
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