Amino-Indanol-Catalyzed Asymmetric Michael Additions of Oxindoles to Protected 2-Amino-1-nitroethenes for the Synthesis of 3,3'-Disubstituted Oxindoles Bearing α,β-Diamino Functionality
Xiong-Li Liu; Zhi-Jun Wu; Xi-Lin Du; Xiao-Mei Zhang; Wei-Cheng Yuan; Journal of Organic Chemistry 76 (2011) 4008–4017; doi:10.1021/jo2004378

data_4026309
_publ_section_title
;
 Amino-Indanol-Catalyzed Asymmetric Michael Additions of Oxindoles to
 Protected 2-Amino-1-nitroethenes for the Synthesis of 3,3'-Disubstituted
 Oxindoles Bearing \a,\b-Diamino Functionality
;
_journal_name_full               'Journal of Organic Chemistry'
_journal_page_first              4008
_journal_page_last               4017
_journal_paper_doi               10.1021/jo2004378
_journal_volume                  76
_journal_year                    2011
_chemical_absolute_configuration ad
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_exptl_absorpt_process_details
;
CrysAlisPro, Oxford Diffraction Ltd.,
Version 1.171.34.36 (release 02-08-2010 CrysAlis171 .NET)
(compiled Aug  2 2010,13:00:58)
empirical absorption correction using spherical harmonics,
 implemented in SCALE3 ABSPACK scaling algorithm.
;
_exptl_crystal_colour            colorless
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_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   -0.01(7)
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.051
_refine_ls_hydrogen_treatment    constr
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_refine_ls_number_reflns         3470
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_refine_ls_R_factor_all          0.0303
_refine_ls_R_factor_gt           0.0296
_refine_ls_shift/su_max          0.000
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[\s^2^(Fo^2^)+(0.0349P)^2^+0.1562P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0712
_refine_ls_wR_factor_ref         0.0717
_reflns_number_gt                3401
_reflns_number_total             3470
_reflns_threshold_expression     >2sigma(I)
_cod_data_source_file            jo2004378_si_001.cif
_cod_data_source_block           lxl2010001
_cod_original_sg_symbol_H-M      'P 21'
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