Antiproliferative activity of a series of cisplatin-based Pt(iv)-acetylamido/carboxylato prodrugs.
Ravera, Mauro; Gabano, Elisabetta; Zanellato, Ilaria; Fregonese, Federico; Pelosi, Giorgio; Platts, James A.; Osella, Domenico; Dalton transactions (Cambridge, England : 2003) 45 (2016) 5300–5309; doi:10.1039/c5dt04905a

data_7038327
_publ_section_title
;
 Antiproliferative activity of a series of cisplatin-based
 Pt(iv)-acetylamido/carboxylato prodrugs.
;
_journal_issue                   12
_journal_name_full
'Dalton transactions (Cambridge, England : 2003)'
_journal_page_first              5300
_journal_page_last               5309
_journal_paper_doi               10.1039/c5dt04905a
_journal_volume                  45
_journal_year                    2016
_chemical_formula_sum            'C6 H17 Cl2 N3 O3 Pt'
_chemical_formula_weight         445.21
_chemical_name_systematic
;
cis, cis, trans-dichloro-diammine-acetamidato-butanoato platinum(IV)
;
_space_group_crystal_system      monoclinic
_space_group_IT_number           14
_space_group_name_Hall           '-P 2ybc'
_space_group_name_H-M_alt        'P 1 21/c 1'
_symmetry_space_group_name_Hall  '-P 2ybc'
_symmetry_space_group_name_H-M   'P 1 21/c 1'
_atom_sites_solution_hydrogens   geom
_audit_creation_method           SHELXL-2014
_audit_update_record
;
2016-02-05 deposited with the CCDC.
2016-02-09 downloaded from the CCDC.
;
_cell_angle_alpha                90
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_cell_angle_gamma                90
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_cell_length_c                   13.361(2)
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_cell_measurement_temperature    293(2)
_cell_measurement_theta_max      18
_cell_measurement_theta_min      9
_cell_volume                     1378.4(4)
_computing_cell_refinement
;
SAINT: SAX, Area Detector Integration, Siemens Analytical instruments
INC., Madison, Wisconsin, USA. 
;
_computing_data_collection
;
SAINT: SAX, Area Detector Integration, Siemens Analytical instruments
 INC., Madison, Wisconsin, USA. 
;
_computing_data_reduction
;
SAINT: SAX, Area Detector Integration, Siemens Analytical instruments
 INC., Madison, Wisconsin, USA. 
SADABS: Siemens Area Detector Absorption Correction Software, 
Sheldrick G., 1996, University of Goettingen, Germany.
;
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'PARST -  M. Nardelli, J. Appl. Crystallogr. 1995, 28, 659'
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_diffrn_measured_fraction_theta_max 0.997
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_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           MoK\a
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_diffrn_reflns_Laue_measured_fraction_full 0.999
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_exptl_absorpt_correction_type   multi-scan
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_exptl_crystal_size_min          0.400
_refine_diff_density_max         2.662
_refine_diff_density_min         -1.550
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_refine_ls_extinction_method     none
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_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0574P)^2^+0.5526P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
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_reflns_number_gt                3024
_reflns_number_total             3752
_reflns_threshold_expression     'I > 2\s(I)'
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_cod_depositor_comments          'Adding full bibliography for 7038327.cif.'
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_shelx_estimated_absorpt_t_min   0.061
_shelx_estimated_absorpt_t_max   0.101
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