Iodine-mediated cascade amination enables one-pot access to antimicrobial indole-embedded dihydropyrazoles.
Ajay Krishna, M. S.; Ashitha, K. T.; Bhat, Meghashyama Prabhakara; Rudrappa, Muthuraj; Athira, C. S.; Lalshikanther Basha, A. L.; Varughese, Sunil; Vankadari, Naveen; Nayaka, Sreenivasa; Somappa, Sasidhar B.; Organic & biomolecular chemistry 24 (2026) 2676–2682; doi:10.1039/d6ob00043f

data_7161067
_publ_section_title
;
 Iodine-mediated cascade amination enables one-pot access to antimicrobial
 indole-embedded dihydropyrazoles.
;
_journal_issue                   13
_journal_name_full               'Organic &amp; biomolecular chemistry'
_journal_page_first              2676
_journal_page_last               2682
_journal_paper_doi               10.1039/d6ob00043f
_journal_volume                  24
_journal_year                    2026
_chemical_formula_sum            'C29 H22 Br N3'
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_audit_update_record
;
2025-04-04 deposited with the CCDC.	2026-03-12 downloaded from the CCDC.
;
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_refine_ls_extinction_expression Fc^*^=kFc[1+0.001xFc^2^\l^3^/sin(2\q)]^-1/4^
_refine_ls_extinction_method     'SHELXL-2018/3 (Sheldrick 2018)'
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_refine_ls_number_reflns         4259
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_refine_ls_restrained_S_all      1.068
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_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0629P)^2^+5.9031P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.1324
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_reflns_number_total             4259
_reflns_threshold_expression     'I > 2\s(I)'
_cod_data_source_file            d6ob00043f2.cif
_cod_data_source_block           shelx
_cod_depositor_comments          'Adding full bibliography for 7161067.cif.'
_cod_database_code               7161067
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