Total Synthesis of (-)-Martinellic Acid via Radical Addition-Cyclization-Elimination Reaction
Atsushi Shirai; Okiko Miyata; Norimitsu Tohnai; Mikiji Miyata; David J. Procter; David Sucunza; Takeaki Naito; Journal of Organic Chemistry 73 (2008) 4464–4475; doi:10.1021/jo800560p

data_4023481
_publ_section_title
;
 Total Synthesis of (-)-Martinellic Acid via Radical
 Addition-Cyclization-Elimination Reaction
;
_journal_name_full               'Journal of Organic Chemistry'
_journal_page_first              4464
_journal_page_last               4475
_journal_paper_doi               10.1021/jo800560p
_journal_volume                  73
_journal_year                    2008
_chemical_formula_moiety         'C14 H14 N2 O2 '
_chemical_formula_sum            'C14 H14 N2 O2'
_chemical_formula_weight         242.28
_space_group_IT_number           4
_symmetry_cell_setting           monoclinic
_symmetry_Int_Tables_number      4
_symmetry_space_group_name_Hall  'P 2yb'
_symmetry_space_group_name_H-M   'P 1 21 1'
_audit_creation_date             2007-11-28
_audit_creation_method           'by CrystalStructure 3.8'
_cell_angle_alpha                90.0000
_cell_angle_beta                 103.13(14)
_cell_angle_gamma                90.0000
_cell_formula_units_Z            2
_cell_length_a                   5.297(10)
_cell_length_b                   15.04(4)
_cell_length_c                   7.486(11)
_cell_measurement_reflns_used    1195
_cell_measurement_temperature    296.1
_cell_measurement_theta_max      65.5
_cell_measurement_theta_min      6.1
_cell_volume                     581(2)
_computing_cell_refinement       PROCESS-AUTO
_computing_data_collection       PROCESS-AUTO
_computing_data_reduction        CrystalStructure
_computing_publication_material  'CrystalStructure 3.8'
_computing_structure_refinement  SHELXL
_computing_structure_solution    SIR2004
_diffrn_detector_area_resol_mean 10.00
_diffrn_measured_fraction_theta_full 0.946
_diffrn_measured_fraction_theta_max 0.946
_diffrn_measurement_device_type  'Rigaku RAXIS-RAPID'
_diffrn_measurement_method       \w
_diffrn_radiation_type           'Cu K\a'
_diffrn_radiation_wavelength     1.54187
_diffrn_reflns_av_R_equivalents  0.063
_diffrn_reflns_limit_h_max       4
_diffrn_reflns_limit_h_min       -6
_diffrn_reflns_limit_k_max       17
_diffrn_reflns_limit_k_min       -18
_diffrn_reflns_limit_l_max       8
_diffrn_reflns_limit_l_min       -8
_diffrn_reflns_number            3454
_diffrn_reflns_theta_full        68.22
_diffrn_reflns_theta_max         68.22
_exptl_absorpt_coefficient_mu    0.766
_exptl_absorpt_correction_T_max  0.926
_exptl_absorpt_correction_T_min  0.383
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details
;
    Higashi, T. (1995). Program for Absorption Correction.
    Rigaku Corporation, Tokyo, Japan.
;
_exptl_crystal_colour            colorless
_exptl_crystal_density_diffrn    1.385
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       prism
_exptl_crystal_F_000             256.00
_exptl_crystal_size_max          0.40
_exptl_crystal_size_mid          0.40
_exptl_crystal_size_min          0.10
_refine_diff_density_max         0.36
_refine_diff_density_min         -0.38
_refine_ls_abs_structure_details
'Flack, H. D. (1983), Acta Cryst. A39, 876-881.  800 Friedel Pairs'
_refine_ls_abs_structure_Flack   0.4(7)
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.139
_refine_ls_hydrogen_treatment    refall
_refine_ls_number_parameters     164
_refine_ls_number_reflns         1846
_refine_ls_R_factor_gt           0.0797
_refine_ls_shift/su_max          0.0100
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w = 1/[\s^2^(Fo^2^)+(0.1660P)^2^+0.3378P] where P=(Fo^2^+2Fc^2^)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_ref         0.2606
_reflns_number_gt                1615
_reflns_number_total             1846
_reflns_threshold_expression     F^2^>2.0\s(F^2^)
_cod_data_source_file            jo800560p-File002.cif
_cod_data_source_block           '_040513___________________'
_cod_original_formula_sum        'C14 H14 N2 O2 '
_cod_database_code               4023481