Organocatalytic Asymmetric Synthesis of 3,3'-Pyrrolidinyl-bispirooxindoles via Michael/ N-Hemiketalization Cascade Reaction between 3-Aminooxindoles and Isatin-Derived β,γ-Unsaturated α-Keto Esters.
Lin, Ye; Zhao, Bo-Liang; Du, Da-Ming; The Journal of organic chemistry 83 (2018) 7741–7750; doi:10.1021/acs.joc.8b00632

data_4035610
_publ_section_title
;
 Organocatalytic Asymmetric Synthesis of
 3,3'-Pyrrolidinyl-bispirooxindoles via Michael/ N-Hemiketalization
 Cascade Reaction between 3-Aminooxindoles and Isatin-Derived
 \b,\g-Unsaturated \a-Keto Esters.
;
_journal_issue                   15
_journal_name_full               'The Journal of organic chemistry'
_journal_page_first              7741
_journal_page_last               7750
_journal_paper_doi               10.1021/acs.joc.8b00632
_journal_volume                  83
_journal_year                    2018
_chemical_absolute_configuration ad
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_diffrn_reflns_theta_max         25.048
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_exptl_absorpt_coefficient_mu    0.091
_exptl_crystal_colour            colourless
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_exptl_crystal_description       cuboid
_exptl_crystal_F_000             1104
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_refine_ls_abs_structure_details
;
 Refined as an inversion twin.
;
_refine_ls_abs_structure_Flack   0.6(12)
_refine_ls_extinction_method     none
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_refine_ls_R_factor_all          0.0541
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_refine_ls_shift/su_mean         0.001
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'w=1/[\s^2^(Fo^2^)+(0.0681P)^2^+0.5856P] where P=(Fo^2^+2Fc^2^)/3'
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_reflns_Friedel_fraction_max     1.000
_reflns_number_gt                4064
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